histology of cartlage by dr roomi
Post on 06-Apr-2018
232 Views
Preview:
TRANSCRIPT
-
8/2/2019 Histology of Cartlage by Dr Roomi
1/22
HISTOLOGY OF
CARTILAGE
BY
DR. MUDASSAR ALI ROOMI (MBBS, M. Phil.)
-
8/2/2019 Histology of Cartlage by Dr Roomi
2/22
cartilage
One of the skeletal tissue, the other being thebone.
Rigid in nature like bone
Like all other C.T it has cells and intercellularmatrix.
Intercellular matrix= fibers +ground substance
incartilage, the ground substance has mainly
chondroitin SO4. In bonethe ground substance is mainly
impregnated with inorganic salts.
-
8/2/2019 Histology of Cartlage by Dr Roomi
3/22
Features ofthecartilage
Avascular
No lymphatics
No nerves
-
8/2/2019 Histology of Cartlage by Dr Roomi
4/22
Perichondrium
Found on peripheries of non-articular hyaline andelastic cartilage (MCS)
It has got two layers:
1. fibrouslayer:Peripheral layer is dense vascularconnective tissue with type I collagen
2. cellularlayer:Inner layer is chondrogenic andgives rise to chondroblasts that secrete cartilage
matrix Articular hyaline cartilage of bones and
fibrocartilage not lined by perichondrium (MCQ)
-
8/2/2019 Histology of Cartlage by Dr Roomi
5/22
Cartilage Matrix
Produced and maintained by chondrocytes andchondroblasts
Contains large GAGs, proteoglycan aggregates and
is highly hydrated
Allows diffusion and is semi rigid shock absorber
GAGs: chondroitin SO4, Keratan SO4 and
hyaluronic acid
Adhesive glycoprotein chondronectin binds cellsand fibrils to surrounding matrix
-
8/2/2019 Histology of Cartlage by Dr Roomi
6/22
Cartilage Cells
Primitive mesenchyme cells differentiate into
chondroblasts that synthesize the matrix
Mature cartilage cells, chondrocytes, becomeenclosed in lacunae
Inner layer of surrounding connective tissue
perichondrium is chondrogenic
Chondroblasts enlarge the cartilage
-
8/2/2019 Histology of Cartlage by Dr Roomi
7/22
Hyaline Cartilage
Mostcommoncartilage in the body
Hyaline= glass like
Covered by perichondrium
serves as a skeletal model for most bones (MCQ)
Replaced by bone during endochondral ossification
Contains type II collagen fibrils (MCQ)
Fibers are invisible Under light microscope because the
refractive index of type II collagen fibers and that ofground substance is the same (MCQ)
-
8/2/2019 Histology of Cartlage by Dr Roomi
8/22
Hyaline Cartilage
-
8/2/2019 Histology of Cartlage by Dr Roomi
9/22
Hyaline Cartilage
-
8/2/2019 Histology of Cartlage by Dr Roomi
10/22
Hyaline Cartilage
-
8/2/2019 Histology of Cartlage by Dr Roomi
11/22
Distribution ofhyalinecartilage
1. Articular cartilage (no perichondrium)
2. Costal cartilages
3. Nasal cartilages4. Cricoid, thyroid and arytenoid cartilages of
larynx
5. Cartilages of trachea and bronchi6. Epiphyseal cartilage of growing long bones.
-
8/2/2019 Histology of Cartlage by Dr Roomi
12/22
hyalinecartilage
-
8/2/2019 Histology of Cartlage by Dr Roomi
13/22
-
8/2/2019 Histology of Cartlage by Dr Roomi
14/22
Elastic Cartilage
Contains branching elastic fibers in matrix and
is highly flexible
The fibers are visible but of elastic variety.
Occurs at places where support with flexibilty
is required.
Type II collagen fibers also present here (MCQ) This cartilage is covered by perichondium
(MCQ)
-
8/2/2019 Histology of Cartlage by Dr Roomi
15/22
Elastic Cartilage
-
8/2/2019 Histology of Cartlage by Dr Roomi
16/22
Distribution ofElastic cartilage
1. Auricle of the External ear
2. Cartilagenous part of the External auditary
meatus3. Epiglotis
4. Eustachian tube
5. Smal laryngeal cartilages (cuneiform andcorniculate)
-
8/2/2019 Histology of Cartlage by Dr Roomi
17/22
-
8/2/2019 Histology of Cartlage by Dr Roomi
18/22
Fibrocartilage
-
8/2/2019 Histology of Cartlage by Dr Roomi
19/22
Histology of Fibrocartilage
-
8/2/2019 Histology of Cartlage by Dr Roomi
20/22
fibrocartilage
-
8/2/2019 Histology of Cartlage by Dr Roomi
21/22
Distribution of fibrocartilage
Intervertebral disc
Disc of the pubic symphysis
Intra-articular discs e.g. semilunar cartilages(menisci) of the knee joint
Glenoid labrum (of shoulder joint)
Acetabular labrum(of hip joint)
-
8/2/2019 Histology of Cartlage by Dr Roomi
22/22
Functions ofcartilage
1. Support soft tissues of the body
2. Provides smooth sliding surfaces in the joints
to facilitate the movements3. Cartilage is essential for the growth of long
bones before and after birth
top related