human populaon gene+cs · 2020. 1. 3. · overview • hardy-weinberg equilibrium • inbreeding...
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HumanPopula+onGene+cs
Overview• Hardy-Weinbergequilibrium• Inbreeding&RGD• Humanorigins
Hardy-Weinberg
Hardy-Weinberg
GrahamCoop,UCDavis
Randomgene+cdriD • Foundereffects– AshkenaziJews
Condi&on CarrierFrequency
Tay-Sachs 1/30
Canavandisease 1/40
Cys+cfibrosis 1/29
Familialdysautonomia 1/32
Bloomsyndrome 1/100
FanconianemiagroupC 1/89
Gaucherdisease 1/15
MucolipidosistypeIV 1/127
Niemann-Pickdisease 1/90
Glycogenstorage1a 1/71
Maplesyrupurinedisease 1/81
Randomgene+cdriD • Foundereffects– AshkenaziJews– Amish– Hu]erite– Afrikanerpopula+on
• Morphometrictraits– Cranialevolu+on
Cavalli-Sforza2005Rosenbergetal.2002
Popula+ondifferen+a+on
Popula+ondifferen+a+on
JNovembreetal.Nature000,1-4(2008)doi:10.1038/nature07331
Inbreeding
CeballosandAlvarez2013
Humanorigins
Humanorigins
Ramachandran S et al. 2005
Humanorigins
Greenetal.2010
Humanorigins
Humanorigins
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