hydrogen sulfide as a novel cardiovascular therapeutic muhammad mobeen zafar 12-arid-1337
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Hydrogen Sulfide as a Novel Cardiovascular Therapeutic
Muhammad Mobeen Zafar
12-arid-1337
Contents
• Introduction• History• H2S
– Metabolism– Functions
• Recent Advances• Future prospects• Refernences
Gasotransmitters
• Gaseous signaling molecules that possess a unique ability to freely diffuse through cell membranes and regulate cellular signaling
• NO, CO and H2S
• 1981 discovery• 2002
Conditions
• Small molecule of gas• Permeable to membranes• Endogenously and enzymatically
generated and its production is regulated• Well defined and specific functions at
relevant concentrations• Should have specific cellular and
molecular targets
History
• 1987 NO (vasodilator in mammals)• 1991 CO (cardiovascular mediator that
upregulates protective mechanisms)• 2002 H2S (cytoprotective)
• European Network on Gasotransmitters (ENOG) in 2011
H2S
• Discovered in 2002• Unstable molecule• Endogeneously produce
H2S Functions
• Neuroprotective• Cytoprotective• Treatment for atherosclerosis• Antioxident activity• Cardioprotective
ADVANCES IN THERAPEUTICS
Complications
• Suitable Compound• Optimum concentration• Delivery mechanism
H2S Donors
• NaHS (Tablet)• Na2S Salts (Tablet)
• Diallyl trisulfide • SG-1002 • GYY4137 ( Water Soluble)
Future prospects
• H2S could act as a biomarker enabling the severity of coronary artery disease progression
• Delivery mechanism• Molecular insights
References
• Discoveries of Hydrogen Sulfide as a Novel Cardiovascular Therapeutic. Larry A. Barr, PhD; John W. Calvert, PhD (Circ J 2014; 78: 2111 – 2118
• Regulation of cardiovascular cell function by hydrogen sulfide (h2s). David j elsey 1, robert c fowkes 2 and gary f baxter cell biochem funct 2012; 28: 95–106.
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