introducing inforsense kanishka karunanayake kanishka@inforsense.com
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Introducing InforSense
Kanishka Karunanayakekanishka@inforsense.com
Proprietary and Confidential © InforSense LtdProprietary and Confidential © InforSense Ltd
Why Scientific Workflow?
Today researchers and decision-makers need effective and timely access to the right information, expertise and derived knowledge to fuel innovation and drive productivity
The Workflow Paradigm
Describes the process of transforming and analysing data to deliver the desired insights
And provides the glue to integrate distributed applications
Proprietary and Confidential © InforSense LtdProprietary and Confidential © InforSense Ltd
What does InforSense do?
We provide a workflow engine that: Provides an open Integrative Analytics environment
that ties together your information resources and software applications across domains and functions
Supports innovation and capture of the best work practices of your scientific/business decision making
Leverages the scalability of Oracle
We provide workflow warehousing to: Manage decision making processes across your
organisation Construct an enterprise process/workflow
knowledge bank where it is easy to modify and reuse workflows
We provide flexible workflow deployment engines to: Turn your workflows into reusable decision services
in a manner best suited to your users (web services, client/server, portals, or .net clients)
Provide the appropriate capabilities to your researchers, informaticians, and managers
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Integrative Analytics Workflow Environment
Expert User
/Analyst
Enumeration &descriptors
Lab & analytical
data
VisualizationCompound & activity data
ID Business Solutions
Databases & documents
Experiment & design
Analytics
Heterogeneous Data, Applications, Analytic Components
Deployed Applications
Workflow Warehouse
Ubiquitous Workflows, Warehouses and Deployment
Engines
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InforSense Architecture Overview
App Server Tier Third Tier Services
Inforsense Web Service
Engine
InforSense EJBsUserspaceExecution
Data managementNode SDKServer API
J2EE JBoss
RDBMS
Webservices
Client Tier
Browser
InforSense Client
3rd Party Clients
Java Component Strategy
Command Line Strategy
InforSense .net Client
Web Services Strategy
Deployment Strategies
Native Executables
Authentication services
JAAS e.g. LDAP, ActiveDirectory
Batch Systems
Sun Grid Engine, LSF
SOAP
RMI
RMI/SOAP
RMI
HTTP/HTTPS
JDBC
SOAP
JAAS
Workflow Warehousing
Oracle
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Openness: Working with any vendors
Searching Oracle DB Searching Oracle DB using JChem Cartridgeusing JChem Cartridge
Output SD Output SD filefile
Input list to Input list to pipeline pilotpipeline pilot
Analyse in Analyse in PPPP
Combine PP data Combine PP data columns with columns with
ongoing analysisongoing analysis
Output list of Output list of IDs for IDs for
screeningscreening
Retrieve data Retrieve data from ABasefrom ABase
Add derived Add derived columns from columns from
xls filexls file
Analyse in Spotfire Analyse in Spotfire and return results and return results
set to KDE for set to KDE for further analysisfurther analysis
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Deployment: Building Personal Applications
Deployment : Vertical applications created from workflows
Create workflow using InforSense client
Deploy by point and click GUI
Define actions Deploy
Molecular Input View Result
Define properties
Deployed Workflow
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Deployment: Building Personal Applications
Proprietary and Confidential © InforSense LtdProprietary and Confidential © InforSense Ltd
ChemAxon Integration Path
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Workflows incorporating ChemAxon Technology
<Workflow Movies><Workflow Movies>
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Demo implements an expanded version of an original method reported in: Shipp et al Nature Medicine January 2002 Volume 8 Number 1 pp 68 – 74.
Analysis of Lymphoma Genomic Data -- Searching for Relevant Genes and New
Drugs
Relevant GenesLiterature Search/Text Mining
Candidate Drug Search
Sequence Analysis
• Genes
• Papers
• Pathways
• Candidate Drugs
E.g. Eli Lily’s Protein Kinase C Inhibitor LY317615
Prediction ModelCellular Pathway AnalysisPatient Data
Gene Expression Data
Data Acquisition Multiple Types of Analysis Relevant Results Data Acquisition Multiple Types of Analysis Relevant Results
Visualization
MethodologyMethodology
Proprietary and Confidential © InforSense LtdProprietary and Confidential © InforSense Ltd
Proprietary and Confidential © InforSense LtdProprietary and Confidential © InforSense Ltd
Proprietary and Confidential © InforSense LtdProprietary and Confidential © InforSense Ltd
Drug Search
Proprietary and Confidential © InforSense LtdProprietary and Confidential © InforSense Ltd
With InforSense•1 Person
•10 Days
•60 Nodes
•Share reusable workflows and data
•Collaborate on all aspects of work
•Flexibility, automation and reproducibility
•Rapid application deployment
Without InforSense•3 People
•90 Days
•1000’s of lines of customised code
Novel Indication for existing
Protein Kinase C Inhibitor LY317615
ROI - Integrative Analysis Example
Novel Discovery & KnowledgeNovel Discovery & KnowledgeNovel Discovery & KnowledgeNovel Discovery & Knowledge
WorkflowsWorkflowsWorkflowsWorkflows
Proprietary and Confidential © InforSense LtdProprietary and Confidential © InforSense Ltd
InforSense Introduction & Mission
Cambridge, MA
London (HQ)
European Field Office
Shanghai
Japanese Distributors
Company founded Nov 1999 to commercialize Imperial College large scale integrative analytics IP
50 staff plus 20 developers in Shanghai
Mission:Mission:
Provide market leading integrative analytics software to enable enterprises to create, integrate, and leverage decision making knowledge more effectively
6 out of top 15 pharma are customers
Windber Research InstituteWindber Research InstituteWindber Research InstituteWindber Research Institute
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Customer Comments…
“I believe this is the best software for analysis, visualization and integration …” “I believe this is the best software for analysis, visualization and integration …”
– Dr. Keisuke Imai, Chief Technical Scientist, Fujisawa Pharmaceutical Co.– Dr. Keisuke Imai, Chief Technical Scientist, Fujisawa Pharmaceutical Co.
– Stephen Calvert, Vice President, Cheminformatics, GSK.– Stephen Calvert, Vice President, Cheminformatics, GSK.
“… [InforSense’s] proven multi-platform integration will enable us to exploit our existing informatics investment and provide a highly extensible discovery environment for the future."
“… [InforSense’s] proven multi-platform integration will enable us to exploit our existing informatics investment and provide a highly extensible discovery environment for the future."
– Dr. Herbert Köppen, Head of Chemoinformatics, Boehringer Ingelheim – Dr. Herbert Köppen, Head of Chemoinformatics, Boehringer Ingelheim
“... The challenge is both to facilitate this dynamic and iterative [decision making] process, and at the same time, capture the key decisions that are made so they can be improved over time.”
“… InforSense workflow technology provides a scalable integration solution, enabling our scientists to develop, enhance and share discovery services. With InforSense, we will ensure that the technology we build our infrastructure upon is an industry standard.”
“... The challenge is both to facilitate this dynamic and iterative [decision making] process, and at the same time, capture the key decisions that are made so they can be improved over time.”
“… InforSense workflow technology provides a scalable integration solution, enabling our scientists to develop, enhance and share discovery services. With InforSense, we will ensure that the technology we build our infrastructure upon is an industry standard.”
Proprietary and Confidential © InforSense LtdProprietary and Confidential © InforSense Ltd
Contact InforSense
InforSense Limited 459a Fulham Road London SW10 9UZ (UK)
t: +44 (0) 20 7808 9500 f: +44 (0) 20 7808 9501
InforSense LLC25 Moulton StreetCambridge, MA 02138 (USA)
t: +1 617 547 2500f: +1 617 547 2772
Additional information can be found at
www.inforsense.com
For enquiries, product information and collaboration, please email me at:
kanishka@inforsense.com
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