introducing inforsense kanishka karunanayake [email protected]

Introducing InforSense

Kanishka [email protected]

Proprietary and Confidential © InforSense LtdProprietary and Confidential © InforSense Ltd

Why Scientific Workflow?

Today researchers and decision-makers need effective and timely access to the right information, expertise and derived knowledge to fuel innovation and drive productivity

The Workflow Paradigm

Describes the process of transforming and analysing data to deliver the desired insights

And provides the glue to integrate distributed applications


What does InforSense do?

We provide a workflow engine that: Provides an open Integrative Analytics environment

that ties together your information resources and software applications across domains and functions

Supports innovation and capture of the best work practices of your scientific/business decision making

Leverages the scalability of Oracle

We provide workflow warehousing to: Manage decision making processes across your

organisation Construct an enterprise process/workflow

knowledge bank where it is easy to modify and reuse workflows

We provide flexible workflow deployment engines to: Turn your workflows into reusable decision services

in a manner best suited to your users (web services, client/server, portals, or .net clients)

Provide the appropriate capabilities to your researchers, informaticians, and managers


Integrative Analytics Workflow Environment

Expert User

/Analyst

Enumeration &descriptors

Lab & analytical

data

VisualizationCompound & activity data

ID Business Solutions

Databases & documents

Experiment & design

Analytics

Heterogeneous Data, Applications, Analytic Components

Deployed Applications

Workflow Warehouse

Ubiquitous Workflows, Warehouses and Deployment

Engines


InforSense Architecture Overview

App Server Tier Third Tier Services

Inforsense Web Service

Engine

InforSense EJBsUserspaceExecution

Data managementNode SDKServer API

J2EE JBoss

RDBMS

Webservices

Client Tier

Browser

InforSense Client

3rd Party Clients

Java Component Strategy

Command Line Strategy

InforSense .net Client

Web Services Strategy

Deployment Strategies

Native Executables

Authentication services

JAAS e.g. LDAP, ActiveDirectory

Batch Systems

Sun Grid Engine, LSF

SOAP

RMI

RMI/SOAP

RMI

HTTP/HTTPS

JDBC

SOAP

JAAS

Workflow Warehousing

Oracle


Openness: Working with any vendors

Searching Oracle DB Searching Oracle DB using JChem Cartridgeusing JChem Cartridge

Output SD Output SD filefile

Input list to Input list to pipeline pilotpipeline pilot

Analyse in Analyse in PPPP

Combine PP data Combine PP data columns with columns with

ongoing analysisongoing analysis

Output list of Output list of IDs for IDs for

screeningscreening

Retrieve data Retrieve data from ABasefrom ABase

Add derived Add derived columns from columns from

xls filexls file

Analyse in Spotfire Analyse in Spotfire and return results and return results

set to KDE for set to KDE for further analysisfurther analysis


Deployment: Building Personal Applications

Deployment : Vertical applications created from workflows

Create workflow using InforSense client

Deploy by point and click GUI

Define actions Deploy

Molecular Input View Result

Define properties

Deployed Workflow


Deployment: Building Personal Applications


ChemAxon Integration Path


Workflows incorporating ChemAxon Technology

<Workflow Movies><Workflow Movies>


Demo implements an expanded version of an original method reported in: Shipp et al Nature Medicine January 2002 Volume 8 Number 1 pp 68 – 74.

Analysis of Lymphoma Genomic Data -- Searching for Relevant Genes and New

Drugs

Relevant GenesLiterature Search/Text Mining

Candidate Drug Search

Sequence Analysis

• Genes

• Papers

• Pathways

• Candidate Drugs

E.g. Eli Lily’s Protein Kinase C Inhibitor LY317615

Prediction ModelCellular Pathway AnalysisPatient Data

Gene Expression Data

Data Acquisition Multiple Types of Analysis Relevant Results Data Acquisition Multiple Types of Analysis Relevant Results

Visualization

MethodologyMethodology


Drug Search


With InforSense•1 Person

•10 Days

•60 Nodes

•Share reusable workflows and data

•Collaborate on all aspects of work

•Flexibility, automation and reproducibility

•Rapid application deployment

Without InforSense•3 People

•90 Days

•1000’s of lines of customised code

Novel Indication for existing

Protein Kinase C Inhibitor LY317615

ROI - Integrative Analysis Example

Novel Discovery & KnowledgeNovel Discovery & KnowledgeNovel Discovery & KnowledgeNovel Discovery & Knowledge

WorkflowsWorkflowsWorkflowsWorkflows


InforSense Introduction & Mission

Cambridge, MA

London (HQ)

European Field Office

Shanghai

Japanese Distributors

Company founded Nov 1999 to commercialize Imperial College large scale integrative analytics IP

50 staff plus 20 developers in Shanghai

Mission:Mission:

Provide market leading integrative analytics software to enable enterprises to create, integrate, and leverage decision making knowledge more effectively

6 out of top 15 pharma are customers

Windber Research InstituteWindber Research InstituteWindber Research InstituteWindber Research Institute


Customer Comments…

“I believe this is the best software for analysis, visualization and integration …” “I believe this is the best software for analysis, visualization and integration …”

– Dr. Keisuke Imai, Chief Technical Scientist, Fujisawa Pharmaceutical Co.– Dr. Keisuke Imai, Chief Technical Scientist, Fujisawa Pharmaceutical Co.

– Stephen Calvert, Vice President, Cheminformatics, GSK.– Stephen Calvert, Vice President, Cheminformatics, GSK.

“… [InforSense’s] proven multi-platform integration will enable us to exploit our existing informatics investment and provide a highly extensible discovery environment for the future."

“… [InforSense’s] proven multi-platform integration will enable us to exploit our existing informatics investment and provide a highly extensible discovery environment for the future."

– Dr. Herbert Köppen, Head of Chemoinformatics, Boehringer Ingelheim – Dr. Herbert Köppen, Head of Chemoinformatics, Boehringer Ingelheim

“... The challenge is both to facilitate this dynamic and iterative [decision making] process, and at the same time, capture the key decisions that are made so they can be improved over time.”

“… InforSense workflow technology provides a scalable integration solution, enabling our scientists to develop, enhance and share discovery services. With InforSense, we will ensure that the technology we build our infrastructure upon is an industry standard.”

“... The challenge is both to facilitate this dynamic and iterative [decision making] process, and at the same time, capture the key decisions that are made so they can be improved over time.”

“… InforSense workflow technology provides a scalable integration solution, enabling our scientists to develop, enhance and share discovery services. With InforSense, we will ensure that the technology we build our infrastructure upon is an industry standard.”


Contact InforSense

InforSense Limited 459a Fulham Road London SW10 9UZ (UK)

t: +44 (0) 20 7808 9500 f: +44 (0) 20 7808 9501

InforSense LLC25 Moulton StreetCambridge, MA 02138 (USA)

t: +1 617 547 2500f: +1 617 547 2772

Additional information can be found at

www.inforsense.com

For enquiries, product information and collaboration, please email me at:

[email protected]

introducing inforsense kanishka karunanayake [email protected]

Documents

confidential inforsense

workflow slide

analysis slide

drug search slide

chemaxon technology

analysing data

workflow engine

pp data columns