nio age - unifect...free radical scavenger, inhibitor of lipoxygenase and cycloxygenase, inhibitor...
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From Nature the Synergic Natural Complex Developed
to Delay Skin Aging Fighting Free Radicals
Anti-Wrinkle Effect in 4 weeks
Skin Hydration +27%
Skin Elasticity +15%
NIO-AGE
Niosome Technology
PHLORETIN FROM APPLE SKIN
EXTRACT
ROS SCAVENGING & DERMAL MATRIX PROTECTION
Free radical scavenger, inhibitor of lipoxygenase and
cycloxygenase, inhibitor of collagenase and elastase
PUNICA GRANATUM
SEED EXTRACT
HYDRATION & ROS PROTECTION
Punicic Acid (~65%), an Omega-5 Fatty Acid
anti-oxidant and moisturizer
MAGNOLOL/
HONOKIOL
ANTI-OXIDANT & ANTI-INFLAMMATORY
Reduce inflammatory signals and dermal matrix
degradation
NIOSOME DELIVER ACTIVE INGREDIENTS
WHERE MUST BE REALLY EFFECTIVE
DRIVING THROUGH THE STRATUM CORNEUM
Ultra-Deformable Niosome are elastic vesicles able to
squeeze through Stratum Corneum reaching living cells inside
epidermis increasing the bioavailability of active ingredients
NIOSOME + FLUORESCEIN FLUORESCEIN ALONE
CLASSIC ACTIVE INGREDIENTS
NIO-AGE
NATURAL INGREDIENTS ARE ENCAPSULATED
INSIDE NIOSOME VESICLES
Phloretin
Punica Granatum
Seed Extract
Magnolol/
Honokiol
A NATURAL COMPLEX TO DELAY SIGNS OF AGING
NIO-ACTIVE NATURAL INGREDIENTS
ULTRA-DEFORMABLE NIOSOME The Most Advanced Skin Delivery System
NIO-AGE MODE OF ACTION
Soft and Smooth Skin Wrinkles, Laxity, Fragility
With NIO-AGE STRESS FACTORS
Chrono&Photo Aging, Pollution, Poor Nutrition
Inflammation Signals
Dermal Matrix
Degradation Enzymes
Dermal Matrix Alteration
Inflammation Signals
Dermal Matrix
Improvement
Hydration & Elasticity
NIO-AGE delays the process of skin aging defending cells from oxidative
metabolism and photo-aging at multiple levels.
Thanks to its specific composition, NIO-AGE fights free radicals, regulates
inflammation, inhibits lipoxygenase and cycloxigenase.
It reduces elastase and collagenase activity preventing degradation of dermal
matrix components responsible of wrinkles, skin laxity and fragility.
NIO-AGE IS THE ANTI-AGE COMPLEX DEVELOPED TO PROTECT SKIN HEALTH REDUCING FINE
LINES AND WRINKLES TO MAKE YOUR SKIN SOFT, ELASTIC, HYDRATED AND COMFORTABLE
i n fo @ n a t u r a l i s . i t
IN VIVO EFFICACY
NIO-AGE ON SKIN HYDRATION Measurement of Skin Hydration using Dermalab Combo tecnique
applying 3% NIO-AGE cream on face vs placebo twice daily for
45 days
NIO-ACTIVE ON SKIN ELASTICITY Measurement of Skin Elasticity using Cutometer MP580
(Courage&Khazaka, Cologne Germany) applying 3% NIO-
AGE cream on face vs placebo twice daily for 8 weeks
NIO-AGE ON WRINKLES APPEARANCE Assessment of skin condition applying 3% NIO-AGE twice daily for 28 days
NIO-AGE ON FIBROBLAST SURVIVAL Viability of HaCaT Human Keratinocyte Cells pre-treated 12 hours with 0-2 mg/ml NIO-AGE
solution after 2 hours H2O2 exposure
0
20
40
60
80
100
120
Fib
rob
last
Via
bili
ty
Ctrl 0,0 0,5 1,0 2,0
NIO-AGE mg/ml
H2O2 100 µmol/l
IN VITRO EFFICACY
100µM H2O2 100µM H2O2
2.0 mg/ml NIO-AGE
Control
+
NIO-AGE Placebo
0,0
10,0
20,0
30,0
40,0
50,0
NIO-AGE
Placebo
0 5 10 15 20
AFTER 4 WEEKS
% C
ha
ng
e c
om
pa
red
T0
% Change compared T0
Address: Via Ozanam, 4
20811 Cesano Maderno (MB) - Italy
Phone: +39 0362 545457
Fax: +39 0362 526364
Site: www.naturalis.it
Mail: info@naturalis.it
NIO-AGE
Niosome Technology
INCI NAME
Phloretin, Magnolol/Honokiol, Punica Granatum Seed Extract, Polyglyceryl-10 Oleate, Apricot Kernel Oil Polyglyceryl-6 Esters, Sorbitan Palmitate, Aqua/Water
SAFETY & TOXICITY
Reference COMMISSION REGULATION (EC) No 987/2008 of 8 October 2008 amending Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorization and Restriction of Chemicals (REACH):
• non-irritating
• non-toxic
FORMULATION SUGGESTIONS
Use Levels: 1 - 3%
pH range: 3,5 - 8,5
Incorporation: Diluite in water before blending. Do not heat above 50°C
Origin: Botanical
Application: Lotions, O/W and W/O emulsions, Gels
Preservative: None
Solubility: Dispersible in water
Compliant regulation: US - EU - China - Japan
Certification: COSMOS Approved
COSMETIC APPLICATION
• ANTI-AGE DAY AND NIGHT CARE
• ACTIVE MAKE-UP
• SUN CARE
CLAIMS
• ANTI-AGING
• ANTI FREE RADICAL
• MOISTURIZING
FOR WRINKLE PREVENTION
The brochure is not intended for consumers and any extract must be used to market products. No design, photography or other extract derived from this brochure are to be used without our prior written approval.
The person using the active ingredient set out in this brochure in the formulation of finished products is solely responsible for ensuring that the ingredient is in compliance with all applicable laws and regulations. We
hereby disclaim all warranties of suitability of the principle set out in this brochure for any porpouse. Any potential user of the principle must himself determine the suitability of the ingredient for its intended use.
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