penicillinase resistant penicillins ( prp ) -1940, 90% s. aureus strains were sensitive to pen g...
Post on 23-Dec-2015
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- Slide 1
- Penicillinase Resistant Penicillins ( PRP ) -1940, 90% S. aureus strains were sensitive to pen G -1960, 50% S. aureus were seusitive to pen G - -Beecham : synthesized thousands of semisynthetic Penicillins, Screened against P.P. S. aureus - Due to the bulky side chain in methicillin, it will not fit into the tube acive site -Methicillin is mainly excreted renally, Interstitial nephritis
- Slide 2
- Penicillinase Resistant Penicillins ( PRP ) Isoxazole PRP Oxacillin:- -Relatively orally active -Excreted both renally and hepatically -Oral absorption is incomplete due to high polarity - Cloxacillin is more lipophilic than oxacillin and has a better oral absorption - Dicloxacillin is the best in case of oral absorption - Dicloxacillin and flucloxacillin are used for mixed Staph & Strept infections
- Slide 3
- Penicillinase Resistant Penicillins ( PRP ) a- Tonsilitis, Dicloxacillin and better yet augmentin b- Impetigo Skin disease Dicloxacillin and better yet oral cefuroxime axetil and topical mupirocin Bactroban -The advantage of nafcillin is that it is excreted hepatically and is good candidate in case of renal insufficiency
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