preliminary clinical results of adipose derived stem cell injection for
Post on 13-Feb-2017
217 Views
Preview:
TRANSCRIPT
Preliminary clinical results of adipose derived stem cell injection
for facet joint syndrome
Ralf D. Rothoerl 1,2, Christopher Alt 2, Alexander Preuss1, Christopher Muller3,
Peter Lackermeier3
1 Department for Neurosurgery, 2 Center for Regenerative Medicine and Sports Medicine 3 Department of Anesthesia
Isarklinikum Munich, Germany,
• 70 % suffer from chronic low back pain
• 50 % of days of sick leave are due to back pain
• Facet joint syndrome is a common cause
Facet joint syndrome
Facetten
Facet joint syndrome
• Degenerative disease
• Athrosis of the spinal joints
• Inflammatory activation
Athrosis
chronic inflammation
• Cortisol injections
• Physiotherapy
• NSAR
• Radiofrequency
• Treatment response 50-70 %
Weber et al 2015
Standard treatment
Immunsuppressive effect of ADSCs
W Nathaniel Brennen et al.
Endocr Relat Cancer
approx. 20min 45 min 15 min
Treatment process
Liposuction Separation Injection
InGeneron
• VAS 7-8 back pain
• No radiating pain
• Cortisol injections temporaryeffect
• SVF LWK 4/5 und 5/SWK1
Case Report
• VAS 1 back pain
• 30 months Follow-up
Back pain
• 19 male patients
• age range 31-78 years, mean 59
• Duration of symptoms > 1 year
• Positive test injection (Ropivacain)
75% pain relief
• Liposuction (mild sedation)
Material and methods
• Injection facet joints under fluoroscopic guidance
• VAS
• Oswestry Disability index
• Follow–up > 1 year
• Side effects
Materialis and methods
Pain relief after 48 hours
VAS 7.2 mean vs. VAS 1,8 mean postoperatively
ODI 74,3% vs. ODI 19,1%
Folllow-up13,2 months
Longest follow-up16 months.
Results
Results
0
10
20
30
40
50
60
70
80
ODI mean prä ODI mean post
Zeile 9
0
1
2
3
4
5
6
7
8
VAS mean prä VAS mean post
Zeile 9
• SVF may be used for regulating inflammatory responses in degenerative diseases of the musculoskeletal system characterized by chronic inflammation
• No side effects
• No long term data
.
Conclusions
top related