rabies, the fury virus. pathogenesis bite site striated muscle cells peripheral nervous system is...
Post on 21-Dec-2015
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Rabies, the Fury Virus
Pathogenesis
• Bite site
• striated muscle cells
• peripheral nervous system is exposed in neuromuscular spindles
• exposed sensory nerve endings and motor end plates
Pathogenesis (cont)
• Neuronal infection (towards the center)
• CNS
• Brain and Salivary Glands
Why it is so evasive
• There may be very little virus and virus antigen delivered to evoke an immune response
• There may be very little virus and virus antigen produced in muscle early in the infection and very little in the peripheral nerves and CNS .
Why it is the fury disease
• Virus enters the saliva an multiplies exponentially at the same time it causes a fury effect in the limbic system.
End result
• The virus enters the neocortex.– Causes the dumb stage– Death by respiratory distress
Control
• Immunization– currently spend 1 billion dollars in U.S. alone– looking for more effective drugs
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