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Mallory bodies. Hyaline
(eosinophilic) inclusions
(arrow) are present in the
cytosol of hepatocytes.
.
A and B, Right-sided Bell's palsy
showing inability to fully close the
eye and drooping of the corner of
the mouth
.
Acid-fast stain of a lung biopsy in
a patient with reactivation
tuberculosis due to
Mycobacterium tuberculosis
.
Acoustic neuroma showing spindle-
shaped cells with alternating dark
and light areas
.
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Bronchopneumonia showingpatchy areas of
consolidation
.
Cerebellum in a patient with rabies
showing Purkinje cells with
intracytoplasmic, eosinophilic inclusions
(arrows) called Negri bodies
.
Common systemic fungal infections. The yeast
form of Cryptococcus neoformans (A) produces
a narrow-based bud (arrow). Coccidioides
immitis (B) has spherules containing
endospores (arrows). Multinucleated giant cells
.
Dependent pitting edema showing depressions
in the skin around the ankle. Pitting edema is
due to an increase in vascular hydrostatic
pressure or a decrease in vascular oncotic
pressure (hypoalbuminemia)
.
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Dermatographism .
Diffuse membranous glomerulonephritis. The
H[amp ]E (hematoxylin [amp ] eosin)-stained
biopsy (A) shows glomerular basement
membranes that are uniformly thickened. There
is no proliferative component. The silver stain
.
Diffuse type of gastric
adenocarcinoma with signet-ring
carcinoma cells (arrows)
.
Electron micrograph of a type II
pneumocyte showing lamellar
body (arrow) containing surfactant
.
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Embryonated eggs of
Enterobius vermicularis .
Metastatic renal cell carcinoma
showing multiple nodular lesions
scattered throughout the lung
parenchyma
.
Fibroadenoma .
Mallory bodies. Hyaline
(eosinophilic) inclusions (arrow)
are present in the cytosol of
hepatocytes
.
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Fatty change of the liver .
Hydronephrosis of the kidney. There is
marked dilation of the renal pelvis and
calyces with thinning of the overlying
cortex and medulla due to compression
atrophy
.
. Left ventricular
hypertrophy .
.Benign prostatic
hyperplasia .
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Intestinal metaplasia of thegastric mucosal epithelium
in chronic gastritis
.
Squamous dysplasia of the cervix,
a precursor of squamous cell
carcinoma..jpg
.
Acute myocardial infarction
(MI) showing coagulation
necrosis.
.
Acute myocardial infarction (MI)
showing a pale infarction of the
posterior wall of the left ventricle
(bottom left)
.
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Hemorrhagic infarction of the lung.There is a roughly wedge-shaped
area of hemorrhage.jpg
.
Dry gangrene of the toes .
Cerebral infarction showing
liquefactive necrosis .
Caseous granuloma showing a central
area of acellular, necrotic material
surrounded by activated macrophages
(epithelioid cells), lymphocytes, and
multiple multinucleated Langhans-type
giant cells
.
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Enzymatic fat necrosis in
acute pancreatitis .
Apoptosis in the epidermis. The arrow
shows a clear space in the epidermis
containing an intensely eosinophilic
staining cell with a small, dense nucleus.
.
Signs of acute inflammation. The patient has
erysipelas of the face due to group A
streptococcus. Signs of acute inflammation that
are present in the photograph include redness
(rubor) and swelling (tumor)
.
Acute inflammation. Histologic
section of lung in
bronchopneumonia showing
sheets of neutrophils with
multilobed nuclei.
.
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Purulent (suppurative) inflammation. The
photograph shows a skin abscess(furuncle) due to Staphylococcus aureus.
Abscesses are pus-filled nodules located
in the dermis.
.
Fibrinous inflammation. The
epicardial surface of the heart is
covered by a shaggy layer of fibrin
material
.
Pseudomembranous inflammation. There
is necrosis and a yellow-colored exudate
covering the mucosal surface of the colon
due to a toxin produced by Clostridium
difficile.
.
Chronic inflammation. This tissue
shows an infiltrate of
predominantly plasma cells (cells
with eccentric nucleus and
perinuclear clearing) and
lymphocytes
.
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Ehlers-Danlos syndrome .
Keloid formation .
Absolute leukocytosis with left shift.
Arrows point to band (stab) neutrophils,
which exhibit prominence of the
azurophilic granules (toxic granulation).
Vacuoles in the cytoplasm represent
phagolysosomes
.
Malar rash in systemic lupus
erythematosus showing the
butterfly-wing distribution
.
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Systemic sclerosis. The tighteningof the skin around the mouth is
caused by excess collagen.
.
Kaposi's sarcoma in HIV.
Skin lesions are raised, red,
and nonpruritic
.
Patient with signs of volume the mucosal
surface of the tongue is dry. Additional
findings on examination were
hypotension, tachycardia, and decreased
skin turgor. (From Forbes C, depletion
.
Electrocardiogram showing
hyperkalemia. Arrows show
peaked T waves, which are a sign
of hyperkalemia.
.
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Coronary artery thrombosis. In this
specially stained cross-section of
a coronary artery, collagen is blue
and the thrombus is red
.
Pulmonary embolus. The main
branches of the pulmonary artery
are occluded with large-caliber
thromboemboli (saddle emboli)
.
Down syndrome. The facial profile
(A) shows a short stature, small
head with small nose and ears.
The hand (B) shows a single
palmar (simian) crease
.
Turner's syndrome is
characterized by a webbed
neck
.
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Black widow spider .
Brown recluse spider .
Kwashiorkor and marasmus. Left, Child with
kwashiorkor, showing dependent pitting edema
involving the lower legs. Right, Child with
marasmus, showing broomstick extremities with
loss of muscle mass and sub
.
Anorexia nervosa .
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Gums showing the effects of
scurvy .
Tubular adenoma (adenomatous
polyp) of the colon showing a
fibrovascular stalk
.
Lipoma showing a well-
circumscribed yellow tumor (A)
containing benign adipose cells
(B)
.
Cystic teratoma of the
ovary, .
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.Figure 8-4 Squamous cell carcinoma.
The many well-differentiated foci ofeosinophilic-staining neoplastic cells
produce keratin in layers (keratin
pearls)..jpg
.
Adenocarcinoma. Irregular
glands infiltrate the stroma .
Osteogenic sarcoma of the distal
femur. The light-colored mass of
tumor in the metaphysis abuts the
epiphyseal plate (arrow)
.
Metastasis to the liver. The liver
contains multiple nodules that
have a depressed central area
(umbilicated)
.
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Basal cell carcinoma(invasive tumor that does
not metastasize)
.
Malignant melanoma. The lesionon the patient's forearm is black, is
multinodular, and has an irregular
border with areas of pale-gray
discoloration
.
Xanthelasma. Yellow, raised
lesions are noted on the
eyelids in both eyes
.
Hyaline arteriolosclerosis .
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Abdominal aortic aneurysm .
Henoch-Schnlein purpura .
Acute myocardial infarction
(day 7) in the posterior wall
of the left ventricle
.
Fibrinous pericarditis. The surface
of the heart is covered by a
shaggy, fibrinous exudate
.
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Left ventricular aneurysm.The bulging aneurysm has a
thin wall of scar tissue
.
Acute rheumatic fever. Uniform,
verrucoid-appearing sterile
vegetations appear along the line
of closure of the mitral valve
.
Mitral valve prolapse. The arrow
shows prolapse of the posterior
mitral leaflet into the left atrium
.
Aortic stenosis .
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Acute bacterial endocarditis .
Myocarditis. The biopsy shows a
lymphocytic infiltrate with
dissolution of myocardial fibers
.
Peripheral blood reticulocytes with supravital
stain (new methylene blueView drug
information). Red blood cells with thread-like
material in the cytosol represent residual RNA
filaments and protein (arrow
.
Peripheral blood smear in iron deficiency
anemia. The enlarged central area of
pallor in the red blood cell (arrow)
indicates a decrease in hemoglobin
synthesis,
.
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Ringed sideroblasts in a bone marrow aspirate.
Dark blue iron granules around the nucleus of
developing normoblasts (arrows) represent iron
trapped within mitochondria and indicate a
defect in mitochondri
.
Peripheral blood with coarse basophilic
stippling of RBCs in lead poisoning. Note
the mature RBC containing numerous
dots representing ribosomes (arrow)
.
Peripheral blood in megaloblastic
anemia showing the
hypersegmented neutrophil
(arrow) with nine lobes
.
Peripheral blood with spherocytes in hereditary
spherocytosis. Numerous, round, dense red
blood cells (RBCs) without central areas of
pallor represent spherocytes (arrows). The
mean corpuscular hemoglobi
.
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Leukoerythroblastic reaction.
Numerous bone marrow
reticulocytes with a blue
discoloration
.
Peripheral blood with atypical
lymphocyte. The cell shows prominent
nucleoli and coarse nuclear chromatin.
The cytoplasm is abundant and is
indented by adjacent red blood cells
.
Peripheral blood in chronic myelogenous
leukemia. Marked leukocytosis shows
neutrophils at different stages of development
(segmented and band neutrophils,
metamyelocytes and myelocytes)
.
Peripheral blood with
promyelocyte filled with Auer rods
in acute promyelocytic leukemia
.
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Peripheral blood in chronic
lymphocytic leukemia .
Gaucher disease .
Niemann-Pick disease .
Senile purpura .
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Laryngeal squamous cell
carcinoma .
Asbestos body .
Malignant mesothelioma .
Sarcoid granuloma .
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Chest radiograph in
emphysema .
Primary lung cancer .
Small cell carcinoma of the
lung .
Oral thrush .
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Hairy leukoplakia along the
lateral. .
Leukoplakia of the tongue .
.Barrett's esophagus .
. Esophageal varices .
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. Gastric adenocarcinoma .
.Entamoeba histolytica
trophozoites .
. Celiac disease .
.Dermatitis herpetiformis .
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Hemorrhagic infarction .
. Meckel diverticulum .
. Sigmoid diverticulosis .
. Ulcerative colitis. .
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. Crohn's disease .
Tubular adenoma .
. Familial polyposis .
. Acute appendicitis .
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. Centrilobular hemorrhagic
necrosis .
Alcoholic cirrhosis .
. Spider angioma
(telangiectasia) .
.Kayser-Fleischer ring. .
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.Hepatocellular carcinoma .
. Yellow cholesterol stones .
.Black pigmented stones .
. Adult polycystic kidney
disease .
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Normal glomerulus .
.Subepithelial
immunocomplex .
.Red blood cell cast in the
urine .
. Crescentic
glomerulonephritis .
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. Fatty cast under
polarization .
. Diabetic
glomerulosclerosis .
.Acute pyelonephritis. .
.Waxy cast in the urine
sediment .
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. Benign nephrosclerosis .
.Renal cell carcinoma .
Benign prostatic hyperplasia .
.Prostate cancer. Arrow .
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A, Candida.
B, Chlamydia trachomatis. C,
Gardnerella vaginalis. D,
Herpes type
E, Herpes type 2.
F, Human papillomavirus.
.
G, Neisseria gonorrhoeae.
H, Treponema pallidum.
I, Treponema pallidum.
J, Trichomonas vaginalis.
.
.Extramammary Paget's
disease .
.Squamous cell carcinoma
of cervix .
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.Polycystic ovarian
syndrome .
.Simple hyperplasia of
endometria.jpg .
. Endometrial carcinoma .
.Leiomyomas. .
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. Ruptured ectopic tubal
pregnancy .
.Complete hydatidiform
mole .
.Ductal carcinoma in situ
(DCIS) .
.Lobular carcinoma in situ .
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.Infiltrating ductal
carcinoma. .
.Paget's disease of the
breast .
.Acromegaly showing the
patient .
. Primary hypothyroidism .
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Graves' disease .
Papillary carcinoma of
thyroid. .
.Patient with Cushing
syndrome .
.Osteoporosis of vertebral
column .
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.Rheumatoid arthritis .
.Tophi (arrows) .
.Erythema chronicum
migrans .
.Verruca vulgaris (common
wart) .
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.Molluscum contagiosum .
.Erythema infectiosum .
.Varicella infection of skin .
Impetigo of the face .
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. Patient with severe facial
acne .
.Acne rosacea .
. Tinea versicolor. .
. Lymphocutaneous
sporotrichosis .
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.Contact dermatitis. .
.Actinic (solar) keratosis .
Lichen planus showing flat-
topped .
.Psoriasis involving the
elbow .
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.Nail changes in psoriasis .
. Pityriasis rosea .
. Erythema multiforme .
. Erythema nodosum .
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. Granuloma annulare. .
. Acanthosis nigricans .
.Solar lentigo .
. Seborrheic keratosis on
the breast .
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. Compound nevus .
.Lentigo maligna melanoma .
.Anencephaly .
. Neurofibromatosis .
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.Epidural hematoma .
.Subdural hematoma .
.Atherosclerotic stroke. .
.Embolic stroke .
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. Intracerebral hemorrhage .
.Bacterial meningitis .
. Cerebral abscess .
.Fusion of the podocytes. Arrowheads show
fusion of the podocytes, which should be
separated by slit pores. This finding occurs in all
glomerular diseases that present with the
nephrotic syndrome (e.g., minimal change
.
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.Gram stain of Streptococcus
pneumoniae. The sputum stain
shows numerous lancet-shaped
diplococci
.
.Granular immunofluorescence. Granular
irregular deposits in the capillaries are
caused by immunocomplex deposition
(e.g., poststreptococcal
glomerulonephritis
.
. brain of a newborn with
kernicterus. Arrows depict yellow
bilirubin pigment deposited in the
basal ganglia
.
.Herpes zoster .
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.Huntington disease. Coronal section (A)
shows a dilated lateral ventricle andatrophy of the caudate, putamen, and
globus pallidus when compared with a
normal coronal section (B)
.
.If the crystal is blue when parallel
to the slow ray, the crystal
demonstrates positive
birefringence.
.
.Normal peripheral blood smear showing
RBCs. The RBCs are uniform in size, and
the central areas of pallor are slightly less
than half the total diameter of an RBC.
The four dark objects (arrows) outside
.
. Giardia lamblia with two
nuclei .
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. Man with ankylosing
spondylitis .
.Keratoacanthoma .
classic Reed-Sternberg (RS) cell. The large,
multilobed cell with prominent nucleoli is
surrounded by a halo of clear nucleoplasm.
Classic RS cells are more easily found in mixed-
cellularity Hodgkin's lymphoma
.
.Linear immunofluorescence. The uninterrupted
smooth immunofluorescence along the
glomerular basement membrane is caused by
deposition of IgG antibodies directed against
the membrane (e.g., Goodpasture syndrome)
.
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.Liver biopsy stained with Prussianblue in a patient with hereditary
hemochromatosis
.
.Lung biopsy stained with Gomori
methenamine-silver showing
septated hyphae and fruiting body
(inset) of Aspergillus fumigatus
.
.Malignant plasma cells in multiple
myeloma. The majority of malignant
plasma cells show a gray-blue cytoplasm,
peripherally located nuclei, and
perinuclear clearing
.
.Multiple sclerosis showing
multiple areas of demyelinated
white matter (arrows pointing to
brown plaques)
.
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analgesic nephropathyshowing multiple brownish
necrotic papillae (arrows)
.
.Neonatal respiratory
distress syndrome .
.Neurocysticercosis showing
multiple cysts between the gray
and white matter
.
.Optic disk with papilledema
showing loss of the disk margin
and hard exudates (white streaks
.
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Flashcard Set Title: "Goljan Rapid Review Images"Study this set online at: http://www.flashcardexchange.com/cards/goljan-rapid-review-images-601157
.Osteoarthritis. Bonyprotuberances (Heberden's
nodes)
.
.Patient with myasthenia gravisshowing ptosis of the left eye (A)
followed by opening of the eye (B)
after intravenous injection of
Tensilon.
.
.Petechiae in idiopathic
thrombocytopenic purpura
showing pinpoint hemorrhages, a
sign of platelet dysfunction
.
.Pneumocystis jiroveci pneumonia.
This silver-impregnated cytologic
smear
.
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.Poststreptococcal diffuseproliferative
glomerulonephritis
.
.Potassium hydroxide preparation
of skin scrapings showing hyphae
and yeasts
.
.Prostate cancer metastatic to the
vertebral column. Multiple white
foci of metastatic prostate cancer
produce an osteoblastic response
in the bone.
.
.Radiograph of a skull showing
multiple punched out lytic lesions
in multiple myeloma
.
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.Radiograph showing small
bowel obstruction. .
.Saddle embolus occluding
the main branches of the
pulmonary artery
.
.Senile plaque (arrow) shows an
eosinophilic center with
peripherally located distended
neuronal processes (neurites).
.
.Silver stain showing
Helicobacter pylori
organisms.
.
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.Spongiform encephalopathy in
Creutzfeldt-Jakob disease
showing classic bubbles and holes
of the neuropil cell bodies
.
.Subendothelial immunocomplex
deposits viewed with electron
microscopy.
.
.Substantia nigra in a patient with
Parkinson disease (A) and a
normal individual (B)
.
.Tinea capitis due to
Trichophyton tonsurans .
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cytomegalovirus. The enlarged
nuclei of many of the type I
pneumocytes contain large
inclusions
.
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