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AMGEN Sustainability Program

VCEDA Business Outlook Conference

October 2011

2

Amgen Is a Pioneer in Discovery and

Delivery of Vital Medicines

• World’s leading independent

biotechnology company, with a

mission to serve patients

– Amgen medicines have reached 20

million patients

– Presence in nearly 50 countries

• More than 30 years of pioneering

science and vital medicines

• Focus solely on discovering,

developing, and making human

therapeutics

– Specializing in innovative medicines

for serious illness

– Pioneer and world leader in protein

therapeutic manufacturing

• Broad and deep pipeline of novel

product candidates

Marketed Products

For additional information about Amgen products, including

important safety information, visit www.amgen.com

3

Amgen Launched a Formal Environmental

Sustainability Program in 2007

• Know where you are

• Have a strategy

• Set goals

• Improve what you have

• Plan for the future

• Build sustainability into the core of your business

• Announce results

What we’ve found that leads to success:

4

Know Where You Are: Compare

Performance With Industry Peers

0

0.5

1

1.5

Amgen Average

Gig

ajo

ule

s /

Sq

Feet

Total Energy

Note: 2009 Pharmaceutical Environmental Group Benchmarking;

0

2

4

6

Average Amgen

MC

M /

Sq

Feet

Water Intake

0

0.03

0.06

0.09

0.12

Amgen Average

Metr

ic T

on

s / S

q F

eet

Carbon Dioxide

0

1500

3000

4500

6000

7500

Average Amgen Metr

ic T

on

s / M

M S

q F

eet

Total Routine Waste

Availability of data allows focus on things that are most impactful

5

Have a Strategy: High Level Direction to

Achieve Awareness, Consensus and Action

Pillars Strategic Direction

Conservation

• Environmental impacts are understood, managed and measured for continuous improvement

• Supply chain impacts are clearly understood, measured, and reduced where feasible

Design for Environment • Sustainable products, facilities, and processes

through use of green design principles

Transparency

• Amgen reputation enhanced through communications; publish annual Environmental Sustainability report

• Staff embrace environmental stewardship

• Accurate data collected, available in timely manner

6

Set Goals: Specific, Measurable,

Attainable, Relevant, Time-Bound

Reduction to date: 520,000 GJ Target met

Reduction to date: 46,000 MT 62% of

target met

Results of conservation projects through 2010

Reduction to date: 435 MT 62% of

target met

Reduction to date: 660,000 m3 Target met

Reduction to date: 58% Target met

Reduction to date: 3 mpg 75% of

target met

2012 target

Energy Reduce 500,000 GJ

Carbon dioxide Reduce 75,000 MT

Water Reduce 235,000 m3

Waste Reduce 700 MT

Recycling Divert more than 40%

Fuel efficiency Improve by 4 mpg

7

Improve What You Have: Pick the Best

Conservation and Efficiency Opportunities

8

Pure Water Is Critical to Our Industry

Recycling Significantly Reduces Use

Recycled

water

Cooling towers Reverse osmosis

water treatment

9

Work with your Utility Partners to

Maximize Benefits

Technical Assistance Programs

• Benchmarking & Energy Audits

– Trane Cube Program

– Data Center Audit

– Building Re-commissioning

• Equipment Efficiency Studies

– Hydraulic Pumps

– Air Compressors

– Boiler Efficiency

– Steam Trap and Condensate Return Analyses

Rebate and Incentive Program

• Incentivized Projects

– HVAC Airflow Reductions

– Lighting Fixture Upgrades

– Chilled Water Plant Optimization

– Pump Efficiency

– High Efficiency Window Film

• Equipment Rebates

– Boiler Economizer Replacement

• Construction/Renovation Incentives

– Energy Saving Measures (From Energy Models)

Energy Efficiency Calculated Incentive

Program (EECIP)

Continuous Energy Improvement

Program (CEI)

Energy Efficiency Rebates for Business

Steam and Condensate Audit

10

Our Recycling Program Has a Long

History of Success

• Amgen’s recycling program

has been in place since

mid-1990s

• Since 2007, Amgen has

recycled more than 16,000

MT of waste

– 3200 garbage truck loads of

recyclable materials

• Diversion rates continue to

increase

• Waste minimization reduces

both purchase and disposal

costs 0

10

20

30

40

50

60

70

2007 2008 2009 2010

Diversion (Recycle) Rate (%)

We are recycling more and disposing less…

11

Plan For the Future: Testing concepts to be

built into Next Generation Laboratories

• Worked with peers in our

industry to develop new

standards for air flow and set

backs

• Tested automated sash

closures that reduce both

energy use and improve safety.

• Integrated occupancy sensors

for lighting and fume hood

control

• Next generation labs – more

automation, more efficient use

of space,

Amgen CONFIDENTIAL Facilities and Engineering

Fume Hood With ASPS Fume Hood With ASPS

12

Workplace of the Future Integrates

Sustainability

• High Performance HVAC, Intelligent Lighting

System (25% Energy Reduction)

• Waterless Urinals / Efficient Water Fixtures

(40% Water Reduction)

• Extensive Daylighting in Workspace,

Exposed and Reflective Ceilings

• Recycled Content & Low Emitting Materials

• Forest Stewardship Council Certified Wood

• Reuse of Existing Core & Shell

• Demolition and Construction Waste

Recycling Program

• Reflective Roofing

• Landscaping 50% More Water Efficient

• Enhanced Commissioning Process

• Active Utility Performance Measurement &

Occupant Engagement Dashboards

LEED Registered, Project Tracking to LEED Gold

Highly efficient use of collaborative, tech-enabled space greatly

increases environmental benefits from sustainable building systems.

13

Build sustainability into the core of your

business: Manufacturing of the Future

• Improved productivity - smaller plants and equipment for same results

• Portable, reconfigurable equipment: - improved plant effectiveness

• Isolator technology - reduces size of clean space

• Improved cleanability - reduce energy, water and chemicals

Significantly improves:

• Energy use

• Emissions

• Water usage

• Waste water volume

• Solid waste generation

Advances in technology promise to improve plant efficiency –

both business and environmental performance improvements

14

Announce Results: Your Stakeholders

Want to Know How You Are Doing

• Customers

– B2B

– Retail

• Neighbors

• Peers

• Shareholders

• Employees

Amgen’s first environmental sustainability report:

http://wwwext.amgen.com/about/environment/espublications.html

15

Amgen Has Been Recognized For Its

Environmental Sustainability Efforts

• 2010 Waste Reduction Award Program (WRAP)

award was given to Amgen in South San Francisco by

the California Integrated Waste Management Board

• 2010 Puerto Rico Manufacturers Association

Environmental Accomplishment Award, PRMA's

highest honor, awarded to Amgen Puerto Rico for

outstanding and consistent environmental compliance

• 2010 WasteWatch Award was given to Amgen

Thousand Oaks for outstanding achievements in waste

reduction and recycling.

• 2011 U.S. Environmental Protection Agency (EPA)

Environmental Quality Award , presented to Amgen

Puerto Rico; category: business and industry, Region 2

• 2011 Colorado Energy Partner of the Year awarded to

Amgen Colorado for outstanding efforts in making

Colorado a world leader in energy efficiency.

16

Every Company, At any Scale, Can

Achieve Sustainability Success

Know where you are

Have a strategy

Set goals

Improve what you have

Plan for the future

Build sustainability into the core of your business

Announce results

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