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UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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University of Pécs Faculty of Pharmacy
PHARMACY Major
STUDY PROGRAM 2019/2020
Elective and Optional subjects
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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1st semester
OPE-KP1-T ______ Basics of Chemistry 1 ____________________________________________________________________ 5
OPE-SKS-T ______ Inorganic Chemistry Calculations ___________________________________________________________ 7
OPE-BFA-T ______ Physical Basis of Biophysics _______________________________________________________________ 9
OPE-GOM-T _____ Poisonous Mushrooms __________________________________________________________________ 11
OPE-HPR-T ______ Health Promotion ______________________________________________________________________ 13
OPF-H1A-T ______ Medical Hungarian 1A - Communication Skills _______________________________________________ 15
OPF-BBM-T ______ Introduction to Biometrics _______________________________________________________________ 17
OPF-BFM-T ______ Problem Solving in Biometrics ____________________________________________________________ 19
OPF-DME-T ______ Cancer is Preventable! ___________________________________________________________________ 21
OPF-GEM-T ______ GMO ________________________________________________________________________________ 23
OPF-H1B-T ______ Medical Hungarian 1B - Language Points ___________________________________________________ 25
OPF-OTT-T ______ History of Medicine ____________________________________________________________________ 27
OPF-FEA-T ______ Basics of Infectious Disease Epidemiology __________________________________________________ 29
2nd semester
OPE-QAS-T ______ Quantitative Analytical Chemistry Calculation ________________________________________________ 31
OPE-ABI-T ______ Applied Biometrics _____________________________________________________________________ 33
OPE-KP2-T ______ Basics of Chemistry 2 ___________________________________________________________________ 35
OPE-FKS-T ______ Physical Chemistry Problem Solving Seminar ________________________________________________ 37
OPE-DRD-T ______ Drug Design __________________________________________________________________________ 38
OPE-ETI-T _______ Pharmacy Ethics _______________________________________________________________________ 40
OPE-GKT-T ______ History of Manufacture of Medicines _______________________________________________________ 41
OPE-JEA-T ______ Diseases of Signal Transduction ___________________________________________________________ 43
OPF-H2A-T ______ Medical Hungarian 2A - Communication Skills _______________________________________________ 45
OPF-IZM-T ______ Molecular Basis of Muscle Function ________________________________________________________ 47
OPF-XC1-T ______ Extracellular Vesicles: Basics, Isolation and Application Methods 1 _______________________________ 49
OPF-BMK-T _____ Methods and Experiments in Molecular Biology ______________________________________________ 52
OPF-H2B-T ______ Medical Hungarian 2B - Language Points ___________________________________________________ 53
OPF-MGY-T _____ Medicinal Plants in the Mecsek Mountain - Field Study 1 _______________________________________ 55
OPF-PLH-T ______ The Placebo Effect _____________________________________________________________________ 57
OPF-VVE-T ______ Vaccination, Anti-Vaccination Movements: Do More Harm than Good ____________________________ 59
OPF-BAL-T ______ Mineral and Spa Waters, Balneology _______________________________________________________ 61
3rd semester
OPE-TSA-T ______ Statistical Analysis of Thesis and Student Research Projects _____________________________________ 63
OPE-WMI-T ______ Weak Molecular Interactions _____________________________________________________________ 64
OPE-TSS-T ______ Medical Applications of Mass Spectrometry _________________________________________________ 66
OPE-BEE-T ______ Basics of Epidemiology _________________________________________________________________ 68
OPE-EHS-T ______ Hunger, Satiety and Disturbances of Body Weight Regulation ____________________________________ 70
OPF-TG1-T ______ Student Project Research for Students of Pharmaceutist Programme 1______________________________ 72
OPF-TMB-T ______ Molecular Biology of Tumors _____________________________________________________________ 73
OPF-SSG-T ______ Histology Seminar for Pharmacy Students ___________________________________________________ 75
OPF-MGE-T ______ Molecular Gerontology __________________________________________________________________ 77
OPF-IPM-T ______ Innovation and Project Management from a Business Perspective (KÜLÖN KURZUS!!!) ______________ 79
OPF-HB1-T ______ How to Achieve Better Grade in Organic Chemistry 1 __________________________________________ 81
OPF-EBK-T ______ Food Safety and Crisis Situations __________________________________________________________ 83
OPF-H3B-T ______ Medical Hungarian 3B - Medical Communication in Practice for Students of Pharmacy ________________ 85
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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OPF-H3A-T ______ Medical Hungarian 3A - Basics of Medical Communication for Students of Pharmacy_________________ 87
4th semester
OPE-BKM-T _____ Basic Methods of Scientific Research _______________________________________________________ 89
OPE-GMO-T _____ Modelling the Structure and Interactions of Bioactive Molecules__________________________________ 91
OPE-SME-T ______ Spectrometric Identification of Organic Compounds ___________________________________________ 94
OPE-TIZ-T _______ Central Regulation of Feeding and Metabolism. New Approaches _________________________________ 96
OPF-QBI-T ______ Quantum Biology: Quantum Phenomena in Biological Processes _________________________________ 98
OPF-GMI-T ______ Gyógyszerészek a mindennapokban - ANGOL VÁLTOZAT ___________________________________ 101
OPF-H4A-T ______ Medical Hungarian 4A - Basics of Medical Communication for Students of Pharmacy________________ 103
OPF-H4B-T ______ Medical Hungarian 4B - Medical Communication in Practice for Students of Pharmacy _______________ 105
OPF-HB2-T ______ How to Achieve Better Grade in Organic Chemistry 2 _________________________________________ 107
OPF-VAN-T ______ Iron Metabolism: from Molecular Mechanisms to Clinical Consequences __________________________ 109
OPF-SKI-T _______ Basics of Chemical Informatics __________________________________________________________ 111
OPF-CSU-T ______ Miracles of Living Materials ("Realistic" Biochemistry) _______________________________________ 113
OPF-TG2-T ______ Student Project Research for Students of Pharmaceutist Programme 2_____________________________ 115
5th semester
OPE-EFA-T ______ Ethnopharmacobotany __________________________________________________________________ 116
OPE-TG3-T ______ Student Project Research for Students of Pharmaceutist Programme 3_____________________________ 118
OPE-GMK-T _____ Qualitative and Quantitative Analysis of Drugs from Human Tissue ______________________________ 119
OPF-MOD-T _____ Molecular Diagnostics__________________________________________________________________ 121
OPF-MME-T _____ Molecular Medicine ___________________________________________________________________ 123
OPF-MOT-T ______ Molecular Therapies ___________________________________________________________________ 125
OPF-HVS-T ______ Synthesis of Heterocyclic Compounds and Their Application in Therapy __________________________ 127
OPF-GLK-T ______ Bioinorganic Chemistry for Pharmacy Students ______________________________________________ 129
OPF-TS1-T ______ Calculations in Pharmaceutical Technology 1 _______________________________________________ 131
OPF-GKG-T ______ Gas Chromatography __________________________________________________________________ 132
OPF-EGZ-T ______ Exotic Medicinal Plants ________________________________________________________________ 134
ATT5-T _________ Physical Education 5 ___________________________________________________________________ 136
OPF-VGG-T ______ Collecting and Conservation of Wild Native Medicinal Plants ___________________________________ 137
OPF-GMT-T ______ Drug Metabolism and Drug Toxicity ______________________________________________________ 139
6th semester
OPE-STK-T ______ Basics of Stereochemistry _______________________________________________________________ 141
OPF-SNA-T ______ Carbon Nanostructures _________________________________________________________________ 143
OPE-VFM-T ______ Business Development and Management ___________________________________________________ 145
OPE-TG4-T ______ Student Project Research for Students of Pharmaceutist Programme 4_____________________________ 147
OPE-GFK-T ______ Physico-Chemical Bases of Drug Action ___________________________________________________ 148
OPE-FAO-T ______ Applied Health Economics ______________________________________________________________ 150
OPE-ASZ-T ______ The Antimicrobial Drugs and their Clinical Use ______________________________________________ 152
OPE-KPR-T ______ Chemoprevention _____________________________________________________________________ 154
OPF-TS2-T ______ Calculations in Pharmaceutical Technology 2 _______________________________________________ 156
OPF-DTS-T ______ The Role of Drug Transporters ___________________________________________________________ 157
OPF-EXT-T ______ Extraction and Chromatographic Techniques in Medicinal Plant Analysis _________________________ 160
OPF-KNH-T ______ Psychoactive Plants ____________________________________________________________________ 162
OPF-NSG-T ______ Plant Products in the Pharmaceutical Practice________________________________________________ 164
OPF-PNT-T ______ Pharmaceutical Nanotechnology __________________________________________________________ 166
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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7th semester
OPE-FMA-T ______ Data Analysis 1 _______________________________________________________________________ 168
OPE-FM2-T ______ Data Analysis 2 _______________________________________________________________________ 170
OPE-T2F-T ______ Pharmaceutical Biotechnology and its links to Biopharmaceuticals _______________________________ 172
OPE-SHK-T ______ Design and Industrial Manufacture of Medicines _____________________________________________ 174
OPF-KIA-T ______ Essential Oils and Clinical Aromatherapy ___________________________________________________ 176
OPF-XES-T ______ The Fate of Drug ______________________________________________________________________ 178
8th semester
OPE-DRO-T ______ Drug and Substance Abuse ______________________________________________________________ 180
OPE-MGT-T _____ Pharmaceutical Technology of Modified Drug Release ________________________________________ 182
OPE-FAJ-T ______ Pain and Analgesics ___________________________________________________________________ 184
OPE-IVF-T ______ Infections and Immunity ________________________________________________________________ 186
OPF-GTH-T ______ Gene Therapy ________________________________________________________________________ 188
9th semester
OPE-GST-T ______ Special Fields of Pharmacology __________________________________________________________ 190
OPE-GSI-T ______ Pharmaceutical Informatics (ONLY FOR YEAR OF 2009 AND 2010) ____________________________ 192
OPF-SUO-T ______ Emergency Medicine __________________________________________________________________ 194
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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OPE-KP1-T BASICS OF CHEMISTRY 1
Course director: DR. PÁL PERJÉSI, professor
Department of Pharmaceutical Chemistry pal.perjesi@gytk.pte.hu
2 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ autumn semester ▪ recommended semester: 1
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 40 Prerequisites: none
Topic
The course provides an overview of the basic laws of Chemistry concentrating on those that are ubiquitous in the chemistry-related
subjects of the basic modules of the health-related curriculums. The course helps understanding the chemistry-related compulsory
subjects of the modules.
Conditions for acceptance of the semester
The course is in accord with the Code of Studies and Examinations. Participation in the lectures is obligatory. Maximum three absences
can be accepted both from lectures and practices.
Two written will be written during the semester. The result of one of them should be at least 60%, the average of the two should be at
least 50%. The result of the improving test is combined with those of the two midterm tests.
Mid-term exams
Two written will be written during the semester. The result of one of them should be at least 60%, the average of the two should be at
least 50%. The result of the improving test is combined with those of the two midterm tests
Making up for missed classes
There is no opportunity to make up missed classes.
Reading material
- Obligatory literature
Ebbing D.D., Gammon S.D.: General Chemistry, Houghton Miffilin Co., Boston, 2009
- Literature developed by the Department
Almási A., Kuzma M., Perjési P.: General and Inorganic Chemistry - Laboratory Techniques and Practices, electronic educational
material, University of Pécs, 2014
- Notes
- Recommended literature
en.wikibooks.org/wiki/General_Chemistry
Lectures
1 The electronic structure of atom. Elements.
Dr. Perjési Pál
2 The electronic structure of atom. Elements.
Dr. Perjési Pál
3 Chemical bonds. Geometry of molecules.
Dr. Perjési Pál
4 Chemical bonds. Geometry of molecules.
Dr. Perjési Pál
5 Kinetic theory of gases. Gas laws.
Dr. Perjési Pál
6 Kinetic theory of gases. Gas laws.
Dr. Perjési Pál
7 Liquids and solutions. Concentrations.
Dr. Perjési Pál
8 Liquids and solutions. Concentrations.
Dr. Perjési Pál
9 Colligative properties.
Dr. Perjési Pál
10 Colligative properties.
Dr. Perjési Pál
11 Chemical thermodynamics I.
Dr. Perjési Pál
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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12 Chemical thermodynamics I.
Dr. Perjési Pál
13 Chemical kinetics.
Dr. Perjési Pál
14 Chemical kinetics.
Dr. Perjési Pál
15 Chemical equilibrium I. Homogeneous equilibria.
Dr. Perjési Pál
16 Chemical equilibrium I. Homogeneous equilibria.
Dr. Perjési Pál
17 Chemical equilibrium II. Acid-base equilibriums in solution.
Dr. Perjési Pál
18 Chemical equilibrium II. Acid-base equilibriums in solution.
Dr. Perjési Pál
19 Chemical equilibrium III. Heterogeneous equilibria.
Dr. Perjési Pál
20 Chemical equilibrium III. Heterogeneous equilibria.
Dr. Perjési Pál
21 Chemical equilibrium IV. Chemical thermodynamics II.
Dr. Perjési Pál
22 Chemical equilibrium IV. Chemical thermodynamics II.
Dr. Perjési Pál
23 Electrochemistry I. Conductivity of electrolytes.
Dr. Perjési Pál
24 Electrochemistry I. Conductivity of electrolytes.
Dr. Perjési Pál
25 Electrochemistry II. Electrode potential. Galvanic cells.
Dr. Perjési Pál
26 Electrochemistry II. Electrode potential. Galvanic cells.
Dr. Perjési Pál
27 Electrochemistry III. Electrolysis.
Dr. Perjési Pál
28 Electrochemistry III. Electrolysis.
Dr. Perjési Pál
Practices
Seminars
Exam topics/questions
Written tests covering the topics of the lectures.
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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OPE-SKS-T INORGANIC CHEMISTRY CALCULATIONS
Course director: DR. ZSUZSANNA ROZMER, assistant professor
Department of Pharmaceutical Chemistry zsuzsanna.rozmer@aok.pte.hu
2 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ autumn semester ▪ recommended semester: 1
Number of hours/semester: 0 lectures + 0 practices + 28 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 70 Prerequisites: none
Topic
This subject is based on the acquired theoretical knowledge on General and Inorganic Chemistry, with adaptation of the principles to
solve chemical problems. The aim of this course to solve chemical calculations related to the lessons of General and Inorganic Chemistry
1 and give a support for easier understanding of the subject.
Conditions for acceptance of the semester
According to the Code of Studies and Examinations (see on the homepage). During the semester maximum 3 missed classes are
acceptable. Two midterm tests will be written during the semester on the 7th and the 12th weeks. The result of both tests should be above
60%. One re-take chance is allowed.
Mid-term exams
Two written exams during the semester.
Making up for missed classes
There is no opportunity to make up missed classes.
Reading material
- Obligatory literature
Ebbing D.D., Gammon S.D.: General Chemistry, Houghton Miffilin Co., Boston, 2009.
- Literature developed by the Department
Almási A., Kuzma M., Perjési P.: General and Inorganic Chemistry - Laboratory Techniques and Calculations, electronic educational
material, University of Pécs, 2014
- Notes
- Recommended literature
en.wikibooks.org/wiki/General_Chemistry
Lectures
Practices
Seminars
1 Introduction to the calculations on inorganic chemistry (basis of chemistry). Stochiometric calculations.
2 Introduction to the calculations on inorganic chemistry (basis of chemistry). Stochiometric calculations.
3 Stochiometric calculations. Calculation of concentrations.
4 Stochiometric calculations. Calculation of concentrations.
5 Calculation of concentrations, Solubility.
6 Calculation of concentrations, Solubility.
7 Electrolytic dissociation.
8 Electrolytic dissociation.
9 Kolligative properites.
10 Kolligative properites.
11 Thermochemistry (Hess’ Law).
12 Thermochemistry (Hess’ Law).
13 Chemical kinetics. Test 1
14 Chemical kinetics. Test 1
15 pH calculations I.: Hydrolysis of salts.
16 pH calculations I.: Hydrolysis of salts.
17 pH calculations II: Buffers.
18 pH calculations II: Buffers.
19 Solubility equilibria.
20 Solubility equilibria.
21 Calculations based on the balancing of redox equations I
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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22 Calculations based on the balancing of redox equations I
23 Calculations based on the balancing of redox equations II
24 Calculations based on the balancing of redox equations II
25 Calculations on electrochemistry I. Test 2
26 Calculations on electrochemistry I. Test 2
27 Calculations on electrochemistry II
28 Calculations on electrochemistry II
Exam topics/questions
The final grade is established based on the average of each written exams.
Participants
Dr. Almási Attila (KJ5MBZ), Dr. Kulcsár Győző Kornél (R7V5ZT), Dr. Lemli Beáta (WT72P7)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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OPE-BFA-T PHYSICAL BASIS OF BIOPHYSICS
Course director: DR. EMŐKE BÓDIS, assistant professor
Department of Biophysics emoke.bodis@aok.pte.hu
2 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ both semesters ▪ recommended semester: 1
Number of hours/semester: 0 lectures + 0 practices + 24 seminars = total of 24 hours
Course headcount limitations (min.-max.): 5 – 150 Prerequisites: none
Topic
The course addresses the chapters of physics which are necessary for a proper understanding of Biophysics (lecture and practicals).
Beyond theoretical discussions, example problems are solved.
Conditions for acceptance of the semester
Maximum 3 absence is allowed.
Mid-term exams
Making up for missed classes
There is no option.
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
Course related information can be found on the website of the Department of Biophysics (http://biofizika.aok.pte.hu).
- Recommended literature
As a base, any secondary school physics book is useful.
Lectures
Practices
Seminars
1 Mathematical basics. Scalars and vectors
2 Physical quantities and units
3 Newton's laws
4 Conservation of momentum. Collisions
5 Motion on a straight line. Kinetics
6 Motion on a straight line. Dynamics
7 Circular motion, rotation
8 Oscillations
9 Work and energy. Friction
10 The work-energy theorem. Conservation of mechanical energy
11 Hydrostatics
12 Hydrodynamics
13 First and second law of thermodynamics
14 Thermodynamic potentials
15 Electrostatics
16 Ohm's law, Kirchhoff's laws
17 Magnetostatics
18 Magnetic induction
19 Waves
20 Wave- and geometrical optics
21 Atom- and nuclear physics
22 Electromagnetic waves
23 Test writing
24 Test writing
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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Exam topics/questions
Can be found on the website of the Department of Biophysics (http://biofizika.aok.pte.hu)
The seminar strengthens physics theoretical background and provide further understanding through evaluation of exercises (calculations)
hence the written test at the end of the semester includes theoretical questions and exercises.
Participants
Dr. Szabó-Meleg Edina (I0NKTU), Dr. Talián Csaba Gábor (RP9GGL), Leipoldne Víg Andrea Teréz (OL4J1R), Szatmári Dávid
(AIX2L6), Takács-Kollár Veronika Tünde (L5EB78), Tóth Mónika Ágnes (GC6VTC)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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OPE-GOM-T POISONOUS MUSHROOMS
Course director: DR. LORÁND BARTHÓ, professor
Department of Pharmacology and Pharmacotherapy lorand.bartho@aok.pte.hu
2 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ autumn semester ▪ recommended semester: 1
Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours
Course headcount limitations (min.-max.): 5 – 40 Prerequisites: none
Topic
Family physicians may play an important role in the early identification and management of mushroom poisoning (MP).
This course:
- deals with the various types of MP and their symptoms;
- molecular mechanisms encountered with the effects of cytotoxic MPs
- morphological features of the most important toxic mushrooms/fungi and their edible counterparts.
Conditions for acceptance of the semester
- Attending at least 75% of the lessons, passing the oral exam
- Oral exam includes matters of poisonings, as well as recognizing the most important PMs and their edible counterparts
Mid-term exams
Exam on week 12
Making up for missed classes
Individual
Reading material
- Obligatory literature
--
- Literature developed by the Department
CD prepared by Prof. Barthó
Most terms will be explained in the lectures.
- Notes
--
- Recommended literature
--
Lectures
1 Introduction
Dr. Barthó Loránd
2 Amanitas, Lepiotas (parasols) and their poisonings
Dr. Barthó Loránd
3 Amanitas, Lepiotas (parasols) and their poisonings
Dr. Barthó Loránd
4 Amanitas, Lepiotas (parasols) and their poisonings
Dr. Barthó Loránd
5 Amanitas, Lepiotas (parasols) and their poisonings
Dr. Barthó Loránd
6 Other mushrooms with white spores and their poisonings
Dr. Barthó Loránd
7 Other mushrooms with white spores and their poisonings
Dr. Barthó Loránd
8 Mushrooms with pink, brown or black spores
Dr. Barthó Loránd
9 Mushrooms with pink, brown or black spores
Dr. Barthó Loránd
10 Mushrooms with pink, brown or black spores
Dr. Barthó Loránd
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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11 Mushrooms with tubes, pores, wrinkles or spines
Dr. Barthó Loránd
12 Mushrooms with tubes, pores, wrinkles or spines
Dr. Barthó Loránd
13 Molecular mechanisms encountered with the effects of cytotoxic MPs
Dr. Szeberényi József
14 Molecular mechanisms encountered with the effects of cytotoxic MPs
Dr. Szeberényi József
15 Morels, false morels, puff-balls, corals, etc. Pre-exam
Dr. Barthó Loránd
16 Morels, false morels, puff-balls, corals, etc. Pre-exam
Dr. Barthó Loránd
17 Some forensic aspects of MPs
Dr. Barthó Loránd
18 Muscarine, muscimol, ibotenic acid
Dr. Barthó Loránd
19 Coprin, orellanin, aflatoxin
Dr. Barthó Loránd
20 Reprise of poisonous mushrooms
Dr. Barthó Loránd
21 Toxins of moulds
Dr. Barthó Loránd
22 Tasks of GP sin case of MP
Dr. Barthó Loránd
23 Reprise of types of poisoning; Exam
Dr. Barthó Loránd
24 Exam
Dr. Barthó Loránd
Practices
Seminars
Exam topics/questions
Oral exam including matters of poisonings, as well as recognizing the most important PMs and their edible counterparts
Cytotoxic MPs
Gastrointestinal MP
Muscarine-type of MP
Psychotropic MP
Other types of MP
Tasks of the general practitioner in case of MP
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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OPE-HPR-T HEALTH PROMOTION
Course director: DR. ISTVÁN ZOLTÁN KISS, professor
Department of Public Health Medicine istvan.kiss@aok.pte.hu
2 credit ▪ midsemester grade ▪ Elective subject for the Medical-biological module ▪ autumn semester ▪ recommended semester: 1
Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours
Course headcount limitations (min.-max.): 5 – 20 Prerequisites: none
Topic
Health promotion is intimately related not only to preventive medicine, but to the everyday practice of physicians as well. A considerable
part of noninfectious diseases is preventable, morbidity and mortality of these illnesses are decreasable by the implementation of effective
intervention.
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
Neptun Meet Street
Making up for missed classes
There are no make-up classes
Reading material
- Obligatory literature
- Literature developed by the Department
Education material on Neptun
- Notes
- Recommended literature
Lectures
1 Definitions of health. Health and its relation to everyday life.
Dr. Horváth-Sarródi Andrea
2 Theoretical background of health promotion. Salutogenesis and pathogenesis.
Dr. Horváth-Sarródi Andrea
3 Health promotion and health education.
Dr. Horváth-Sarródi Andrea
4 Basic documents of health promotion.
Dr. Horváth-Sarródi Andrea
5 Methods of health promotion.
Dr. Horváth-Sarródi Andrea
6 Measuring of results in health promotion activities. Evidence based health promotion.
Dr. Horváth-Sarródi Andrea
7 Health promotion and health policy.
Dr. Horváth-Sarródi Andrea
8 Lalonde model. Health in all policies (HiAP).
Dr. Horváth-Sarródi Andrea
9 Multisectorality. Stakeholders.
Dr. Horváth-Sarródi Andrea
10 Health Impact Assessment (HIA).
Dr. Horváth-Sarródi Andrea
11 Health promotion in communities.
Dr. Horváth-Sarródi Andrea
12 Health planning.
Dr. Horváth-Sarródi Andrea
13 SWOT-analysis.
Dr. Horváth-Sarródi Andrea
14 Personal health planning.
Dr. Horváth-Sarródi Andrea
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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15 Effective health promotion in settings (schools)
Dr. Horváth-Sarródi Andrea
16 Effective health promotion in settings (work places)
Dr. Horváth-Sarródi Andrea
17 Health Promoting Universities.
Dr. Horváth-Sarródi Andrea
18 Actuality and possibilities of the concept of Health Promoting Universities.
Dr. Horváth-Sarródi Andrea
19 Methods of mental health promotion.
Dr. Horváth-Sarródi Andrea
20 Promotion of positive mental health and possibilities of prevention of mental disorders.
Dr. Horváth-Sarródi Andrea
21 Mental health policy.
Dr. Horváth-Sarródi Andrea
22 Role of physicians in the primary, secondary and tertiary levels of prevention.
Dr. Horváth-Sarródi Andrea
23 Complex health promotion programs.
Dr. Horváth-Sarródi Andrea
24 Examples for effective health promotion activities.
Dr. Horváth-Sarródi Andrea
Practices
Seminars
Exam topics/questions
Neptun Meet Street
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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OPF-H1A-T MEDICAL HUNGARIAN 1A - COMMUNICATION SKILLS
Course director: DR. VILMOS WARTA, associate professor
Department of Languages for Specific Purposes vilmos.warta@aok.pte.hu
2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 1
Number of hours/semester: 0 lectures + 0 practices + 24 seminars = total of 24 hours
Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPE-H1B-T parallel
Topic
To establish basic skills in reading, writing, listening and speaking Hungarian in preparation for effective medical communication.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Written midterm and end of the term tests are compulsory. Other short written tests to be discussed with the course tutor in each individual
case. Several oral tests are taken, dates are to be discussed with the course tutor. Make up tests possible only during the semester classes.
Making up for missed classes
Participation in class work is obligatory. In case absences exceed 25% of total class time, the course will be regarded as uncompleted. In
the case of absences up to 25% of total class time, oral examination will have to be taken
Reading material
- Obligatory literature
Anamnézis magyarul (Magyar orvosi szaknyelv kezdőknek) by Renáta Halász, 2015. Pécs
- Literature developed by the Department
In-house course book: at the homepage of the institute:
http://aok.pte.hu/index.php?page=egyseg&egy_id=60&menu=okt_anyag&nyelv=eng
- Notes
In-house course book: at the homepage of the institute:
http://aok.pte.hu/index.php?page=egyseg&egy_id=60&menu=okt_anyag&nyelv=eng
- Recommended literature
http://aok.pte.hu/index.php?page=egyseg&egy_id=60&menu=okt_anyag&nyelv=eng
Lectures
Practices
Seminars
1 Greeting people, formality and informality
2 Greeting people, formality and informality
3 Addressing people, men and women
4 Addressing people, men and women
5 Starting conversation, the elderly and children
6 Starting conversation, the elderly and children
7 Introducing, equal and unequal relations
8 Introducing, equal and unequal relations
9 Nutritional History Taking
10 Nutrients
11 Nutrients
12 Test 1
13 Health Preservation, Sports, Addictions
14 Writing CV, occupation, work
15 Medical Specialties, Consulting Room and Ward
16 Telling CV, family relations
17 Introducing family
18 Introducing family
19 Describing people - Internal and external features
20 Describing people - Internal and external features
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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21 Health care institutions, consolidation
22 Test 2
23 Evaluation
24 Evaluation
Exam topics/questions
Two written test papers and oral presentation topics to be discussed with the course tutor in each individual case.
Participants
Dávidovics Anna (U5A10Z), Dr. Hegedűs Anita (TQQEMK), Dr. Hild Gabriella (HILSWV), Dr. Németh Tímea (X8VRGN), Dr. Rébék-
Nagy Gábor (DGOZG1), Dr. Warta Vilmos (SJYRAV), Eklicsné Dr. Lepenye Katalin (JMXXSC), Krommer Zoltán (MQ5HNA),
Kurdiné Molnár Eszter (VUCECC), Nagy Gabriella (CYMRX3), Nagy Renáta (), Ronczykné Berta Anikó (CJZOFU), Szalai-Szolcsányi
Judit (RBGAPH), Szántóné Dr. Csongor Alexandra (UDKY0J)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
17
OPF-BBM-T INTRODUCTION TO BIOMETRICS
Course director: DR. LÁSZLÓ PÓTÓ, associate professor
Institute of Bioanalysis laszlo.poto@aok.pte.hu
1 credit ▪ midsemester grade ▪ Optional subject ▪ both semesters ▪ recommended semester: 1
Number of hours/semester: 0 lectures + 12 practices + 0 seminars = total of 12 hours
Course headcount limitations (min.-max.): 1 – 20 Prerequisites: none
Topic
Exploring data (using graphs and numbers) are usually handled as one-lesson ‘first chapter’ by basic statistical courses. This is, because
a first course in statistics introduces many new skills. It also introduces some new ideas, that all are ‘hard to understand’ for students.
The new approach is to make a solid foundation to learn statistics by a more thorough introduction to those: The course tries to make
clear a few of these fundamental ideas of statistics - limited to understanding and working with data. An improved skill for exploring
data is useful not only at your classes and your future job but in the everyday life as well.
Conditions for acceptance of the semester
Maximum one missed class.
Mid-term exams
Active participation at the classes.
Making up for missed classes
One extra class
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
László Pótó: Biometrics, workbook, Pécs, 2018
- Recommended literature
1, Moore, D. S.: The Basic Practice of Statistics, 7th edition, 2015
2, Moore, David S., McCabe, George P.: Introduction to the Practice of Statistics, 5th edition, W.H. Freeman, 2005
and
Yates, Dan, Moore, David S., Starnes, Daren S.: The Practice of Statistics (TI-83/89 Graphing Calculator Enhanced) 2/e, W.H.
Freeman, 2003 or
3, Rees, W. G.: Essential Statistics, Chapman and Hall, 1992
Lectures
Practices
1 Probability examples 1
Dr. Pótó László
2 Probability examples 1
Dr. Pótó László
3 Probability examples 2 - discrete distributions
Dr. Pótó László
4 Probability examples 2 - discrete distributions
Dr. Pótó László
5 Exploring data by graphs
Dr. Pótó László
6 Exploring data by graphs
Dr. Pótó László
7 Exploring data by numbers - sample measures
Dr. Pótó László
8 Exploring data by numbers - sample measures
Dr. Pótó László
9 The normal distribution
Dr. Pótó László
10 The normal distribution
Dr. Pótó László
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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11 Distribution of the mean; Stat estimation: the CI for the expected value
Dr. Pótó László
12 Distribution of the mean; Stat estimation: the CI for the expected value
Dr. Pótó László
Seminars
Exam topics/questions
No exam - but active participation on the classes is a must.
Participants
Dr. Pótó László (FIO4UU)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
19
OPF-BFM-T PROBLEM SOLVING IN BIOMETRICS
Course director: DR. LÁSZLÓ PÓTÓ, associate professor
Institute of Bioanalysis laszlo.poto@aok.pte.hu
1 credit ▪ midsemester grade ▪ Optional subject ▪ both semesters ▪ recommended semester: 1
Number of hours/semester: 0 lectures + 12 practices + 0 seminars = total of 12 hours
Course headcount limitations (min.-max.): 1 – 20 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
Give a chance to have more practice to solve problems in Biometrics using PC and the SPSS software in the computer room. This was a
regular need of the students earlier since the special way how a MD should handle the typical medical problems (special way of thinking)
was not founded by the secondary school education. This foundation is an important focus point of the Biometrics course. It seems, the
weekly 1+1 lectures were not enough for most of the students for completing this important goal: To develop some brand new skills.
This course offers an organized way for that extra practices. It offers also some ‘brushing up’ chances for those who has completed
Biometrics earlier.
Conditions for acceptance of the semester
Maximum one missed class
Mid-term exams
Active participation on the classes.
Making up for missed classes
One extra class
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
László Pótó: Biometrics, workbook, Pécs, 2018.
- Recommended literature
1, Moore, D. S.: The Basic Practice of Statistics, 7th edition, 2015.
or
2, Moore, David S., McCabe, George P.: Introduction to the Practice of Statistics, 5th edition, W.H. Freeman, 2005
and
Yates, Dan, Moore, David S., Starnes, Daren S.: The Practice of Statistics (TI-83/89 Graphing Calculator Enhanced) 2/e, W.H.
Freeman, 2003 or
3, Rees, W. G.: Essential Statistics, Chapman and Hall, 1992
Lectures
Practices
1 The one sample (and the paired samples) t test
Dr. Pótó László
2 The one sample (and the paired samples) t test
Dr. Pótó László
3 The CI and the hypothesis testing - the type one and type two errors.
Dr. Pótó László
4 The CI and the hypothesis testing - the type one and type two errors. MDM basics 1.
Dr. Pótó László
5 The independent samples t test
Dr. Pótó László
6 The independent samples t test
Dr. Pótó László
7 The linear regression
Dr. Pótó László
8 The linear regression
Dr. Pótó László
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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9 The contingency tables - the chi squares test
Dr. Pótó László
10 The contingency tables - the chi squares test. MDM-1/2
Dr. Pótó László
11 The nonparametric tests
Dr. Pótó László
12 The nonparametric tests. MDM basics 2.
Dr. Pótó László
Seminars
Exam topics/questions
No exam but active participation on the classes is a must.
Participants
Dr. Pótó László (FIO4UU)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
21
OPF-DME-T CANCER IS PREVENTABLE!
Course director: DR. ISTVÁN ZOLTÁN KISS, professor
Department of Public Health Medicine istvan.kiss@aok.pte.hu
2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 1
Number of hours/semester: 22 lectures + 2 practices + 0 seminars = total of 24 hours
Course headcount limitations (min.-max.): 5 – 30 Prerequisites: none
Topic
One of the major challenges for the health care system of the 21st century is the high number of cancer caused deaths. Over the past
decades, despite a significant development on the field of medicine, the prognosis of this disease is still not satisfactory. Thus prevention
has a key role in in the fight against cancer. The course gives a description on the different types of cancer their major risk factors for a
more detailed understanding. Methods of cancer prevention will be described and emphasized - including theoretical knowledge and a
practical guide as well. During the course the results of most recent human epidemiological studies on cancer will also be described.
Conditions for acceptance of the semester
Participation in lectures and practicals is obligatory which is registered. Absences should not exceed 4x45 min. Otherwise signature of
grade book is denied.
Mid-term exams
Making up for missed classes
There are no make-up classes.
Reading material
- Obligatory literature
- Literature developed by the Department
Educational material uploaded on Neptun.
- Notes
- Recommended literature
Robert Weinberg (ed.): The Biology of Cancer, Garland Science 2006 ISBN 0815340788
Boffetta P., La Veccia: Neoplasms 2009. In Detels R, Beaglehole R, Lansang MA and Gulliford M (eds.) Oxford Textbook of Public
Health, 5th ed., Oxfort University Press
Lectures
1 Cancer in the 21st century
Dr. Kiss István Zoltán
2 Cancer in developing and developed countries
Dr. Kiss István Zoltán
3 The process of carcinogenesis I.
Dr. Kiss István Zoltán
4 The process of carcinogenesis II.
Dr. Kiss István Zoltán
5 Characteristics of cancer cells
Dr. Kiss István Zoltán
6 Molecular epidemiology of cancer
Dr. Kiss István Zoltán
7 The most important cancer risk factors in general I.
Dr. Kiss István Zoltán
8 The most important cancer risk factors in general II.
Dr. Kiss István Zoltán
9 Lung cancer
Dr. Kiss István Zoltán
10 Colorectal tumors I.
Dr. Kiss István Zoltán
11 Colorectal tumors II.
Dr. Kiss István Zoltán
12 Breast cancer
Dr. Kiss István Zoltán
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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13 Prostate cancer
Dr. Kiss István Zoltán
14 Head and neck cancer
Dr. Kiss István Zoltán
15 Pancreatic cancer
Dr. Kiss István Zoltán
16 Gastric cancer
Dr. Kiss István Zoltán
17 Liver cancer
Dr. Kiss István Zoltán
18 Cervical cancer
Dr. Kiss István Zoltán
19 Ovarian cancer
Dr. Kiss István Zoltán
20 Skin cancer
Dr. Kiss István Zoltán
21 Leukemia
Dr. Kiss István Zoltán
22 Less frequent tumors
Dr. Kiss István Zoltán
Practices
1 Genetics, genomics and epigenetics in cancer prevention
2 Cancer prevention - Recommendations
Seminars
Exam topics/questions
Neptun
Participants
Dr. Kiss István Zoltán (EFZCGE)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
23
OPF-GEM-T GMO
Course director: DR. ZOLTÁN GYÖNGYI, senior research fellow
Department of Public Health Medicine zoltan.gyongyi@aok.pte.hu
2 credit ▪ midsemester grade ▪ Optional subject ▪ both semesters ▪ recommended semester: 1
Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours
Course headcount limitations (min.-max.): 3 – 30 Prerequisites: none
Topic
The application of genetically modified organisms (GMOs) gains more and more ground in food industry. Over the direct health effect,
they have an impact on human economy, health and environment. The topic provokes social debate, in which, in lack of information,
delusions also appear. The tecnology is also used in industry, science and human therapy. During the education, students receive a
knowledge of molecular background of production GMOs, their possible health risks, their occurrence in foodstuffs, medical applications,
detection, regulations, authorization, economical and social impacts.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Providing a new date after individual consultation.
Making up for missed classes
none
Reading material
- Obligatory literature
- Literature developed by the Department
Slides on the Neptun
- Notes
- Recommended literature
Lectures
1 Definition of GMO
Dr. Gyöngyi Zoltán
2 Needs of GMOs in different disciplines
Dr. Gyöngyi Zoltán
3 The development of agriculture to GMOs
Dr. Gyöngyi Zoltán
4 The role of GMOs in crop production
Dr. Gyöngyi Zoltán
5 The role of GMOs in animal breeding
Dr. Gyöngyi Zoltán
6 Impact of GM crops on natural habitats and organic farming
Dr. Gyöngyi Zoltán
7 GMO production. History of science
Dr. Gyöngyi Zoltán
8 GMO production. Description of biotechnology methods
Dr. Gyöngyi Zoltán
9 GMO detection methods
Dr. Gyöngyi Zoltán
10 Occurrence of GM organisms in food, their detectability
Dr. Gyöngyi Zoltán
11 GMO in industry
Dr. Gyöngyi Zoltán
12 GMO in the pharmaceutical industry
Dr. Gyöngyi Zoltán
13 GMO in science
Dr. Gyöngyi Zoltán
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
24
14 GMO and disease prevention
Dr. Gyöngyi Zoltán
15 GMO and therapy
Dr. Gyöngyi Zoltán
16 The past, present and future of gene therapy
Dr. Gyöngyi Zoltán
17 Genetic modification of humans
Dr. Gyöngyi Zoltán
18 Potential health effects of GMOs
Dr. Gyöngyi Zoltán
19 Background of deaths caused by GMOs
Dr. Gyöngyi Zoltán
20 Preventing the harmful effects of GMOs
Dr. Gyöngyi Zoltán
21 Authorization procedures of GMOs
Dr. Gyöngyi Zoltán
22 GMO production for commercial use
Dr. Gyöngyi Zoltán
23 The economic impact of GMOs
Dr. Gyöngyi Zoltán
24 Social debates, publicity
Dr. Gyöngyi Zoltán
Practices
Seminars
Exam topics/questions
A GMO fogalma
A GMO megjelenésének igénye különböző tudományterületeken
A mezőgazdaság fejlődése a GMO megjelenéséig
A GM szervezetek szerepe a növénytermesztésben
A GM szervezetek szerepe az állattenyésztésben
A GM növények hatása természetes élőhelyekre és a biogazdálkodásra
GMO előállítás. Tudománytörténeti áttekintés
GMO előállítás. Biotechnológiai módszerek ismertetése
GMO kimutatási módszerek
A GM szervezetek élelmiszerekben való előfordulása, kimutathatóságuk
GMO az iparban
GMO a gyógyszeriparban
GMO a tudományban
GMO és a betegségmegelőzés
GMO és a gyógyítás
A génterápia múltja, jelene és jövője
Az ember genetikai módosítása
A GM szervezetek lehetséges egészségkárosító hatásai
GM szervezetek okozta halálesetek háttere
A GM szervezetek egészségkárosító hatásának kivédése
A GM szervezetek engedélyezésének feltételei
Kereskedelmi GMO előállítás
A GM szervezetek gazdasági hatása
Társadalmi viták, tájékoztatás
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
25
OPF-H1B-T MEDICAL HUNGARIAN 1B - LANGUAGE POINTS
Course director: DR. VILMOS WARTA, associate professor
Department of Languages for Specific Purposes vilmos.warta@aok.pte.hu
2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 1
Number of hours/semester: 0 lectures + 0 practices + 24 seminars = total of 24 hours
Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPF-H1A-T parallel
Topic
Familiarizing foreign students with basic paradigms used in specific conversations.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Written midterm and end of the term tests are compulsory. Other short written tests to be discussed with the course tutor in each individual
case. Several oral tests are taken, dates are to be discussed with the course tutor. Make up tests possible only during the semester classes.
Making up for missed classes
Participation in class work is obligatory. In case absences exceed 25% of total class time, the course will be regarded as uncompleted. In
the case of absences up to 25% of total class time, oral examination will have to be taken
Reading material
- Obligatory literature
Anamnézis magyarul (Magyar orvosi szaknyelv kezdőknek) by Renáta Halász, 2015. Pécs
- Literature developed by the Department
http://aok.pte.hu/index.php?page=egyseg&egy_id=60&menu=okt_anyag&nyelv=eng
- Notes
In-house course book: at the homepage of the institute:
http://aok.pte.hu/index.php?page=egyseg&egy_id=60&menu=okt_anyag&nyelv=eng
- Recommended literature
http://aok.pte.hu/index.php?page=egyseg&egy_id=60&menu=okt_anyag&nyelv=eng
Lectures
Practices
Seminars
1 Basics of Hungarian Phonetics and Morphology
2 Basics of Hungarian Phonetics and Morphology
3 Personal Pronouns - formal and informal style
4 Personal Pronouns - formal and informal style
5 Constructing Questions - Question Words
6 Constructing Questions - Question Words
7 Numerals - Cardinal, Ordinal, Labels
8 Numerals - Cardinal, Ordinal, Labels
9 Verbs - Definite and Indefinite Conjugation
10 Verbs - Definite and Indefinite Conjugation
11 Expressing Frequency
12 Expressing Frequency
13 Test 1
14 Articles
15 Modality - necessity
16 Modality - necessity
17 Objective Case
18 Verbal prefixes
19 Expressing Time
20 Expressing Time
21 Expressing Location - Trinity of Directions
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
26
22 Dative Case
23 Test 2
24 Course Evaluation
Exam topics/questions
http://aok.pte.hu/index.php?page=egyseg&egy_id=60&menu=okt_anyag&nyelv=eng
Participants
Dávidovics Anna (U5A10Z), Dr. Hegedűs Anita (TQQEMK), Dr. Hild Gabriella (HILSWV), Dr. Németh Tímea (X8VRGN), Dr. Rébék-
Nagy Gábor (DGOZG1), Dr. Warta Vilmos (SJYRAV), Eklicsné Dr. Lepenye Katalin (JMXXSC), Krommer Zoltán (MQ5HNA),
Kurdiné Molnár Eszter (VUCECC), Nagy Gabriella (CYMRX3), Nagy Renáta (), Ronczykné Berta Anikó (CJZOFU), Szalai-Szolcsányi
Judit (RBGAPH), Szántóné Dr. Csongor Alexandra (UDKY0J)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
27
OPF-OTT-T HISTORY OF MEDICINE
Course director: DR. CSILLA RÚZSÁS, associate professor
Department of Operational Medicine ruzsas@gamma.ttk.pte.hu
2 credit ▪ midsemester grade ▪ Optional subject ▪ both semesters ▪ recommended semester: 1
Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours
Course headcount limitations (min.-max.): 5 – 80 Prerequisites: none
Topic
The purpose of the course is to give an opportunity for reviewing the progress in medicine historically, from the ancient times up to the
present époque, on the basis of cultural background. The understanding of the fact that the contemporary medicine is the result of the
efforts of several centuries will be hopefully stimulatory for the students in the professional improvement, realizing that both the
theoretical basis and healing practice are due to the devoted work of previous generations. Accordingly, the progress from healing art to
healing science will be illustrated in relation to the culture of previous centuries.
Since the students of our University come from countries of different cultures and traditions, the progress in medicine of ancient Greek
and Persian and Islamic culture are equally reviewed, besides the European medicine where English and German relations are of
outstanding importance, as reflected by the fact that in German universities, high number of weekly hours are devoted for the history of
medicine. Accordingly, the most outstanding physicians and clinical schools, playing a prominent role in the European progress will be
reviewed.
Our aim is to demonstrate that each culture represents a value which contributes to the common treasure of humanity.
Conditions for acceptance of the semester
Survey of the theoretical basis of medical practice in a historical period.
Mid-term exams
Making up for missed classes
Reading material
- Obligatory literature
- Literature developed by the Department
Summary of the content of each lecture (detailed description of authors and the main outlines of their activity promoting the medicine)
- Notes
- Recommended literature
Delano: The Story of Medicine, London
Benke J.: Az orvostudomány története - Hungarian ed. with English summary, Medicina, Bp. 2008.
Lectures
1 Archaic medicine
Dr. Rúzsás Csilla
2 Ancient Egypt, Mesopotamia, India, traditional Chinese medicine
Dr. Rúzsás Csilla
3 Medicine in Greece in the Antiquity
Dr. Rúzsás Csilla
4 The most outstanding medical schools; Hippocratic medicine
Dr. Rúzsás Csilla
5 Medicine in the Roman times. Galen.
Dr. Rúzsás Csilla
6 Byzantine leading doctors
Dr. Rúzsás Csilla
7 Early medieval medicine in Europe
Dr. Rúzsás Csilla
8 Monasteric medicine in medieval Europe
Dr. Rúzsás Csilla
9 The medicine under Islam
Dr. Rúzsás Csilla
10 The most outstanding physicians of Arabic-Islamic medicine
Dr. Rúzsás Csilla
11 Foundation of the universities in the Middle-Age
Dr. Rúzsás Csilla
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
28
12 Scholastic medicine
Dr. Rúzsás Csilla
13 Medicine in the Renaissance
Dr. Rúzsás Csilla
14 Vesal. Paracelsus.
Dr. Rúzsás Csilla
15 Medicine of the 17th century: the golden age of sciences
Dr. Rúzsás Csilla
16 Raise of natural sciences. Iatrophysics and iatrochemistry
Dr. Rúzsás Csilla
17 The age of the 18th century
Dr. Rúzsás Csilla
18 The age of enlightment. Progress in pathology.
Dr. Rúzsás Csilla
19 Beginnings of modern medicine in the 19th century
Dr. Rúzsás Csilla
20 Medical schools in Europe
Dr. Rúzsás Csilla
21 Specialisation in medicine in the 19th century
Dr. Rúzsás Csilla
22 New approaches and equipment in medicine of the 19th century
Dr. Rúzsás Csilla
23 Medicine in the first half of the 20th century
Dr. Rúzsás Csilla
24 Main trends in medicine in the second half of the 20th century
Dr. Rúzsás Csilla
Practices
Seminars
Exam topics/questions
Possible themes for the essays:
Characteristics of the ancient Egyptian and Mesopotamian culture.
Medicine of ancestral Chinese civilization.
Medicine of Greece in the Antiquity.
Hippocratic medicine and the Hippocratic Collection.
Post-hippocratic medicine: The school of Athens and Alexandria.
Outstanding physicians of Persian and Arabic-Islamic medicine.
Medical education in the Middle-Ages.
The main epidemies in Europe.
The most prominent physicians in the Renaissance.
Main trends in medicine of the 19th century.
Ignatz Semmelweis, the saver of the mothers.
Most important discoveries in medicine in the 20th century.
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
29
OPF-FEA-T BASICS OF INFECTIOUS DISEASE EPIDEMIOLOGY
Course director: DR. ISTVÁN ZOLTÁN KISS, professor
Department of Public Health Medicine istvan.kiss@aok.pte.hu
1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 1
Number of hours/semester: 9 lectures + 3 practices + 0 seminars = total of 12 hours
Course headcount limitations (min.-max.): 5 – 15 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
However the morbidity and mortality caused by infectious diseases has significantly declined in the developed countries in the last
century due to the effective prevention methods, their complete elimination is not possible, infectious diseases are still part of our
everyday life. The spread of infectious diseases could be controlled by timely identification, proper investigation and by targeted
interventions. Aim of the course is to present the special characteristics of infectious diseases, and of infectious disease epidemiology;
basics and functioning of surveillance systems, the basics and steps of an outbreak investigation, and epidemiological methods used
during the investigation.
Conditions for acceptance of the semester
The participation in the lectures, seminars, practises is obligatory (a catalogue should be signed), a maximum of 2x45 min absence is
acceptable, above the signature will be rejected.
Mid-term exams
Making up for missed classes
None
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
Heymann (ed.): Control of Communicable Diseases Manual
Mikanatha, Lynfield, Van Beneden, de Valk (eds.): Infectious Disease Surveillance
Lectures
1 Special characteristics of infectious diseases
Dr. Prantner Ida
2 Basics of infectious disease epidemiology I
Dr. Prantner Ida
3 Basics of infectious disease epidemiology II
Dr. Prantner Ida
4 Methods used in infectious disease epidemiology
Dr. Prantner Ida
5 Basic principles of surveillance
Dr. Prantner Ida
6 Infectious disease surveillance
Dr. Prantner Ida
7 Basics and steps of outbreak investigation I
Dr. Prantner Ida
8 Basics and steps of outbreak investigation II
Dr. Prantner Ida
9 Investigation of a food-borne outbreak
Dr. Prantner Ida
Practices
1 Use of epidemiological knowledge in practice I (definitions, surveillance data interpretation, analysis)
2 Use of epidemiological knowledge in practice II (Data collection, analysis, graphical interpretations)
3 Use of epidemiological knowledge in practice III (analytic studies)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
30
Seminars
Exam topics/questions
Participants
Dr. Prantner Ida (WO4A8D)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
31
OPE-QAS-T QUANTITATIVE ANALYTICAL CHEMISTRY CALCULATION
Course director: DR. GYŐZŐ KORNÉL KULCSÁR, assistant professor
Department of Pharmaceutical Chemistry kulcsar.gyozo@gytk.pte.hu
2 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 0 lectures + 0 practices + 28 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 50 Prerequisites: none
Topic
The Quantitative analytical chemistry calculation course helps students to understand the analytical (titrimetric) calculations. It makes
theoretical backgrounds more understandable.
Conditions for acceptance of the semester
According to the Code of Studies and Examinations (see on the homepage). During the semester maximum 3 missed classes are
acceptable. Two midterm tests will be written during the semester. The result of both tests should be above 60%.
Mid-term exams
Two written exams during the semester.
Making up for missed classes
Missing written exams should be made up.
Reading material
- Obligatory literature
Harris D.C.: Quantitative Chemical Analysis, 8th ed., W.H. Freeman and Co., New York, 2010
- Literature developed by the Department
Handouts.
- Notes
- Recommended literature
Lectures
Practices
Seminars
1 Introduction - Concentrations - Concentration of standard solutions.
2 Introduction - Concentrations - Concentration of standard solutions.
3 Acid-base titrations - Methods for calculating the titration results. Calculations with molarity and normality.
4 Acid-base titrations - Methods for calculating the titration results. Calculations with molarity and normality.
5 Neutralization analysis - Standardization of a titrant. Titration curve calculations.
6 Neutralization analysis - Standardization of a titrant. Titration curve calculations.
7 Calculation of pH in titration problems I. Hydrolysis of salts.
8 Calculation of pH in titration problems I. Hydrolysis of salts.
9 Calculation of pH in titration problems II. Buffers.
10 Calculation of pH in titration problems II. Buffers.
11 Non-aqueous titration calculations.
12 Non-aqueous titration calculations.
13 Complexometry - Methods for calculating the titration results.
14 Complexometry - Methods for calculating the titration results
15 Complex chemical equilibria - Calculations with the stability constants.
16 Complex chemical equilibria - Calculations with the stability constants.
17 Redox titrations II. - Calculations based on oxidimetry.
18 Redox titrations II. - Calculations based on oxidimetry.
19 Redox titrations I. - Redox titration curve calculations.
20 Redox titrations I. - Redox titration curve calculations.
21 Redox titrations I. - Calculations based on oxidimetry.
22 Redox titrations I. - Calculations based on oxidimetry.
23 Redox titrations III. - Calculations based on reductometry.
24 Redox titrations III. - Calculations based on reductometry.
25 Precipitate formation titrations - Calculations for the solubility products.
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26 Precipitate formation titrations - Calculations for the solubility products.
27 Gravimetry.
28 Gravimetry.
Exam topics/questions
The final grade is established based on the average of each written exams.
Participants
Dr. Almási Attila (KJ5MBZ), Dr. Kulcsár Győző Kornél (R7V5ZT)
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OPE-ABI-T APPLIED BIOMETRICS
Course director: DR. KORNÉLIA FARKAS-BORBÁS, assistant professor
Institute of Bioanalysis nelli.farkas@aok.pte.hu
1 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 6 lectures + 6 practices + 0 seminars = total of 12 hours
Course headcount limitations (min.-max.): 1 – 12 Prerequisites: none
Topic
Basics of biometrical methods are indispensable to understand the scientific results, to plan own research, and to evaluate data. The main
goal of the course is to expand and deepened the basic knowledge of biometrics via solving practical problems.
Object of the course is to demonstrate different type of research with most frequently applied biometrical methods, though representative
examples or with using of the data of the participants.
Conditions for acceptance of the semester
Problem solving, oral report
Mid-term exams
Short presentation(s) on the classes by the students
Making up for missed classes
Consultation
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
Andrew F. Siegel: Statistics and Data Analysis. An introduction, John Wiley & Sons, 1988
Douglas G. Altman: Practical Statistics for Medical Research, Chapman & Hall, 1994
P. Armitage and G. Berry: Statistical Methods in Medical Research, Blackwell Science, 1994
Robert R. Sokal / F. James Rohlf: Biometry, W. H. Freeman and Company, New York, 1981
Lectures
1 Introduction to research methodology, refresh the bio-statistical knowledge
Dr. Pótó László
2 Variance analysis
Borbásné Dr. Farkas Kornélia
3 Regression analysis
Dr. Pótó László
4 Correlation analysis
Borbásné Dr. Farkas Kornélia
5 Survival analysis
Borbásné Dr. Farkas Kornélia
6 Factor analysis
Borbásné Dr. Farkas Kornélia
Practices
1 Refresh the bio-statistical knowledge using the SPSS, exercises
2 Variance analysis, post-hoc tests
3 Linear and non-linear regression analysis
4 Parametric and non-parametric(rank-) correlation analysis
5 Survival analysis, Cox-regression analysis...
6 Factor analysis
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Seminars
Exam topics/questions
Participants
Borbásné Dr. Farkas Kornélia (IRWZKJ), Dr. Pótó László (FIO4UU)
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OPE-KP2-T BASICS OF CHEMISTRY 2
Course director: DR. PÁL PERJÉSI, professor
Department of Pharmaceutical Chemistry pal.perjesi@gytk.pte.hu
2 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 50 Prerequisites: none
Topic
Based on the previously acquired high school knowledge the course provides an overview on the basic laws of Chemistry concentrating
on those that are ubiquitous in the chemistry-related subjects of the basic modules of the health related curriculums. The course helps
understanding the chemistry-related compulsory subjects of the modules.
Conditions for acceptance of the semester
Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation in the lectures is obligatory.
Maximum three absences can be accepted both from lectures and practices. Two midterm tests will be written during the semester on the
7th and the 12th weeks. The result of both tests should be above 60%. One re-take chance is allowed after both tests.
Mid-term exams
Making up for missed classes
There is no opportunity to make up missed classes.
Reading material
- Obligatory literature
Ebbing D.D., Gammon S.D.: General Chemistry, Houghton Miffilin Co., Boston, 2009
- Literature developed by the Department
Almási A., Kuzma M., Perjési P.: General and Inorganic Chemistry - Laboratory Techniques and Practices, electronic educational
material University of Pécs, 2014
- Notes
- Recommended literature
en.wikibooks.org/wiki/General_Chemistry
J. McMurray, R. C. Fay: Chemistry, 5th edition
Lectures
1 The electronic structure of atom. Periodic properties.
Dr. Perjési Pál
2 The electronic structure of atom. Periodic properties.
Dr. Perjési Pál
3 Structure of molecules. The valence bond theory
Dr. Perjési Pál
4 Structure of molecules. The valence bond theory
Dr. Perjési Pál
5 Structure of molecules. The molecular-orbital theory.
Dr. Perjési Pál
6 Structure of molecules. The molecular-orbital theory.
Dr. Perjési Pál
7 Bonding in solids
Dr. Perjési Pál
8 Bonding in solids
Dr. Perjési Pál
9 Molecular spectroscopy I. UV-VIS
Dr. Perjési Pál
10 Molecular spectroscopy I. UV-VIS
Dr. Perjési Pál
11 Carbon: structure and reactivity
Dr. Perjési Pál
12 Carbon: structure and reactivity
Dr. Perjési Pál
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13 Nitrogen: structure and reactivity.
Dr. Perjési Pál
14 Nitrogen: structure and reactivity.
Dr. Perjési Pál
15 Oxygen: structure and reactivity.
Dr. Perjési Pál
16 Oxygen: structure and reactivity.
Dr. Perjési Pál
17 Transition metals: structure and reactivity
Dr. Perjési Pál
18 Transition metals: structure and reactivity
Dr. Perjési Pál
19 Coordination compounds I. Metal-ligand bonding I
Dr. Perjési Pál
20 Coordination compounds I. Metal-ligand bonding I
Dr. Perjési Pál
21 Coordination compounds II. Metal-ligand bonding II
Dr. Perjési Pál
22 Coordination compounds II. Metal-ligand bonding II
Dr. Perjési Pál
23 Coordination compounds III. Isomerism
Dr. Perjési Pál
24 Coordination compounds III. Isomerism
Dr. Perjési Pál
25 Coordination compounds IV. Stability.
Dr. Perjési Pál
26 Coordination compounds IV. Stability.
Dr. Perjési Pál
27 Basic photochemistry
Dr. Perjési Pál
28 Basic photochemistry
Dr. Perjési Pál
Practices
Seminars
Exam topics/questions
Written test covering the topics of the lectures.
Participants
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OPE-FKS-T PHYSICAL CHEMISTRY PROBLEM SOLVING SEMINAR
Course director: DR. LÍVIA NAGY-ZENGŐ, senior research fellow
Faculty of Natural Sciences - Department of General and Physical Chemistry lnagy@gamma.ttk.pte.hu
1 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 0 lectures + 0 practices + 14 seminars = total of 14 hours
Course headcount limitations (min.-max.): 3 – 36 Prerequisites: OPA-PC1-T parallel
Topic
This is an elective course, a lecture room practice. It helps the student understanding the ways of calculating quantitative properties of
material, extent of changes and determine important physicochemical parameters. It shows the applicability of the theoretical forms, the
proper using of units in calculations. Showing the applicability of theory it supports bringing close to understanding the principles of
basic course on physical chemistry. The practice is an informal discussion following the physical chemistry I lecturing. The students
obtain problems to solve as home work. These problems are discussed during the practice. During the semester written test are given.
The evaluation is based on the scores. Students taking this course usually can solve easier the calculating problems at the physical
chemistry I course.
Conditions for acceptance of the semester
One class absence can be tolerated.
Mid-term exams
Making up for missed classes
Full solved problems will be handed over in written form for the absent student.
Reading material
- Obligatory literature
P. Atkins, J. de Paula: Physical Chemistry, 8th edition, Oxford University Press 2006, ISBN 9780198700722
- Literature developed by the Department
- Notes
- Recommended literature
P. Atkins, J. de Paula: Physical Chemistry, 8th edition, Oxford University Press 2006, ISBN 9780198700722
D. Freifelder: Physical Chemistry for Students of Biology and Chemistry, Science Books International Inc. ISBN 0 86720-002-2
Lectures
Practices
Seminars
1 The properties of gases: states of perfect gas, the gas laws, units.
2 Basic concepts in thermodynamics, expansion work, internal energy of a system. Application of the first law.
3 Calculation of enthalpy and calorimetry.
4 Calculation of formation enthalpy and the heat capacity (cp, cv).
5 Calculation of the changes in internal energy.
6 Problem solving of entropy, changing of entropy in different processes.
7 Test: the gas laws, the first law, change in internal energy of a system, the heat capacities and entropy
8 Problems of the kinetic model of gases, collision with walls and surfaces.
9 Calculation: First rate chemical reactions.
10 Calculation: First rate chemical reactions, determination of ages by reaction kinetic base.
11 Problem solving of second rate chemical reaction and enzyme reaction
12 Electrochemical calculations: Faraday”s laws, conductivity in electrolytes, Nernst equation, Galvan cells
13 Test: problems fom kinetic model of gases, reaction kinetics and Faraday”s laws.
14 Calculation of electrolysis and corrosion
Exam topics/questions
The solved problems will be handed over in written form for the students at the end of the semester.
Participants
Dr. Nagyné Dr. Zengő Lívia (EOQ0QG)
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OPE-DRD-T DRUG DESIGN
Course director: DR. CSABA HETÉNYI, associate professor
Department of Pharmacology and Pharmacotherapy hetenyi.csaba@pte.hu
2 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours
Course headcount limitations (min.-max.): 1 – 300 Prerequisites: none
Topic
The course offers an overview of the whole process of drug design between selection of the disease and marketing of the drug. The
introductory lectures are followed by detailed reviews of certain phases of drug design including prediction of both drug action and
pharmacokinetic properties. In this regard, theoretical and experimental methods of drug design will be also introduced. Case studies will
demonstrate successful examples and also difficulties arising during the design process. Students with a researcher attitude are primary
targets of this course. Besides them, the course provides useful knowledge for future medical doctors and pharmacists as it explains the
complex process of drug discovery in a comprehensible way. This hopefully helps the students navigating in the jungle of laws of
pharmacology also used in molecular design. Furthermore, the course deals with the problems of prediction of toxicity and side-effects,
and discusses certain questions of production and legalization process of new drugs, as well. In Journal Club sessions, recent research
articles will be featured with the students to deepen their knowledge in the areas discussed during the previous lectures. In this way, the
students can discover further connections themselves and make sure of the usefulness of their newly obtained knowledge in drug design.
Conditions for acceptance of the semester
Jelenleg a választható és elektív kurzusok esetén a szabályzat nem tartalmaz részvételi követelményt. Amennyiben szükséges itt valamit
megjelölnöm, akkor 25 %, de csak azért teszem, hogy kitölthető legyen az űrlap. Javasoltam a Tanulmányi Bizottság vezetőjének a
helyzet szabályzását és 50 % mértéket a hiányzásoknál.
Mid-term exams
There is a final test announced at the end of the semester. The test will include multiple choice questions and short essays. A mark is
offered according to the results of the written test and optionally by evaluation of the student’s presentation prepared for the Journal
Club. The student can improve the mark according to university regulations.
Making up for missed classes
Replacement is possible according to personal consultation.
Reading material
- Obligatory literature
- Literature developed by the Department
The material of the course including pdfs of lectures and lists of questions will be made downloadable from the web site of the
Department of Pharmacology and Pharmacotherapy or a link will be provided during the lectures / in an e-mail.
- Notes
- Recommended literature
Patrick GL: An Introduction to Medicinal Chemistry, Oxford University Press
Lectures
1 Selection of the disease. Goals, terminology, trends.
Dr. Hetényi Csaba
2 Conditions. Strategies. Ligand-based design.
Dr. Hetényi Csaba
3 Traditional design.
Dr. Hetényi Csaba
4 Target-based drug design.
Dr. Hetényi Csaba
5 Target selection and validation.
Dr. Hetényi Csaba
6 Protein targets 1. General overview, structural proteins.
Dr. Hetényi Csaba
7 Protein targets 2. Enzymes and receptors.
Dr. Hetényi Csaba
8 Experimental structure determination methods.
Dr. Hetényi Csaba
9 Theoretical structure determination methods.
Dr. Hetényi Csaba
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10 Lipids and nucleic acids as targets.
Dr. Hetényi Csaba
11 Journal club 1. Comparison of strategies. Evaluation of targets.
Dr. Hetényi Csaba
12 Journal club 2. X-ray crystallography and NMR. Cryo-electronmicroscopy.
Dr. Hetényi Csaba
13 Experimental methods of lead selection and design.
Dr. Hetényi Csaba
14 Molecular complexes of leads. Thermodynamic and kinetic stability.
Dr. Hetényi Csaba
15 Theoretical methods of lead selection and design.
Dr. Hetényi Csaba
16 Lead optimizations, transformations.
Dr. Hetényi Csaba
17 ADMETox optimization 1. Goals, general description.
Dr. Hetényi Csaba
18 ADMETox optimization 2. Methods.
Dr. Hetényi Csaba
19 Termination of design. Production and development.
Dr. Hetényi Csaba
20 Side-effects and postmarketing surveillance.
Dr. Hetényi Csaba
21 Case study 1. The design of antiviral drugs.
Dr. Hetényi Csaba
22 Case study 2. The design of anti-cancer drugs.
Dr. Hetényi Csaba
23 Journal club 3. Development of new methods. Paradigm shifts of drug design.
Dr. Hetényi Csaba
24 Journal club 4. Molecular dynamics. Docking.
Dr. Hetényi Csaba
Practices
Seminars
Exam topics/questions
Lists of questions will be provided at the end of each lecture specifying the required knowledge.
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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OPE-ETI-T PHARMACY ETHICS
Course director: TIBOR SZOLCSÁNYI, assistant professor
Department of Behavioural Sciences tibor.szolcsanyi@aok.pte.hu
1 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 0 lectures + 0 practices + 12 seminars = total of 12 hours
Course headcount limitations (min.-max.): 5 – 25 Prerequisites: none
Topic
The aim of the course is to help students gain sensitivity to the ethical issues connected to the pharmacy practice. During the course
students learn about the basic ethical principles governing the pharmacist-patient and the pharmacist-physician relationship. Students
also get acquainted with the dilemmas that are raised by the conflict between business and ethics in pharmacy. The most important
concerns of research ethics and some specific ethical issues, like the question of mind-enhancing drugs, are also discussed during the
course.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Written test taking place in the last class. To improve the grade, the test can be repeated two times in the first two weeks of the exam
period. Oral exam is also an option for that purpose.
Making up for missed classes
According to the Code of Studies and Examinations
Reading material
- Obligatory literature
--
- Literature developed by the Department
Additional materials: Neptun MeetStreet
- Notes
--
- Recommended literature
Robert Veatch and Amy Haddad (eds.): Case Studies in Pharmacy Ethics, 2nd edition, Oxford University Press, New York, 2008
Lectures
Practices
Seminars
1 Introduction
2 A short history of pharmacy
3 General ethical viewpoints
4 The principle of informed consent in modern health-care
5 The ethics of patient-pharmacist relationship
6 The ethics of physician-pharmacist relationship
7 The conflict between business and ethics in pharmacy
8 The placebo effect and its ethical concerns
9 Dietary supplements, performance- and mind- enhancing drugs
10 Ethical issues in clinical drug trials
11 Summarizing discussion
12 Test
Exam topics/questions
--
Participants
Dr. Szolcsányi Tibor (HNQ526)
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OPE-GKT-T HISTORY OF MANUFACTURE OF MEDICINES
Course director: DR. SZILÁRD PÁL, assistant professor
Institute of Pharmaceutical Technology and Biopharmacy szilard.pal@aok.pte.hu
2 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 100 Prerequisites: none
Topic
Aim of the course is to explain the importance of the birth of Pharmaceutical Technology, introducing the manufacture of medicines
from the ancient times until the new age. Lectures will explain how first medicines were made, how the first pharmaceutical technological
equipments were created and how the mass production of drugs became more and more important. Lectures will also elaborate the birth
of famous medicines, like the quinine, aspirin, insulin and the sildenafil.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
- participation on the lectures
- accepted work reports
- accepted written assessments
Students have to write an end-semester assessment from the lectures at acceptance level of 60%.
Making up for missed classes
Students must fulfil requirements determined by the Code of Studies and Examinations. Student has make up for the missed lectures and
work reports.
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
Leon Shargel, A. B.C. Yu, Stamford: Applied Biopharmaceutics and Pharmacokinetics
Susanna Wu-Pong, Yon Rojanasakul: Biopharmaceutical Drug Design and Development, Humana Press
Gilbert S. Banker, Christopher T. Rhodes: Modern Pharmaceutics, Marcel Dekker Inc., New York- Basel
Michael J. Rathbone, Michael S. Roberts: Modified-Release Drug Delivery Technology, Informa Healthcare
Michael E. Aulton: The Design and Manufacture of Medicines, Churchill Livingstone
Lectures
1 Introduction
Dr. Pál Szilárd
2 introduction
Dr. Kása Péter
3 Ancient technologies (Egypt, Greece, Persian Empire)
Dr. Pál Szilárd
4 Ancient technologies (Egypt, Greece, Persian Empire)
Dr. Kása Péter
5 Influence of alchemy to the pharmaceutical technology
Dr. Pál Szilárd
6 Influence of alchemy to the pharmaceutical technology
Dr. Kása Péter
7 Middle ages
Dr. Pál Szilárd
8 Middle ages
Dr. Kása Péter
9 Effect of industrial revolution
Dr. Pál Szilárd
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10 Effect of industrial revolution
Dr. Kása Péter
11 Development of medicines in the new age
Dr. Pál Szilárd
12 Development of medicines in the new age
Dr. Kása Péter
13 Birth of the first industrial manufacturers
Dr. Pál Szilárd
14 Birth of the first industrial manufacturers
Dr. Kása Péter
15 Evolution of community pharmacies
Dr. Pál Szilárd
16 Evolution of community pharmacies
Dr. Kása Péter
17 Drugs that changed the world
Dr. Pál Szilárd
18 Drugs that changed the world
Dr. Kása Péter
19 Invention of the quinine
Dr. Pál Szilárd
20 Invention of the aspirine
Dr. Kása Péter
21 Invention of various famous drugs
Dr. Pál Szilárd
22 Invention of the sildenafil
Dr. Kása Péter
23 Invention of the insulin
Dr. Pál Szilárd
24 Invention of the insulin
Dr. Kása Péter
25 Test
Dr. Pál Szilárd
26 Test
Dr. Kása Péter
27 Attending the Saracen Pharmacy in Pécs
Dr. Pál Szilárd
28 Attending the Saracen Pharmacy in Pécs
Dr. Kása Péter
Practices
Seminars
Exam topics/questions
Students can get the test topics in the institute or download the from website of the institute.
Participants
Dr. Kása Péter (ISWPRM), Dr. Pál Szilárd (FYF5E9)
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OPE-JEA-T DISEASES OF SIGNAL TRANSDUCTION
Course director: GYÖRGY SÉTÁLÓ DR., associate professor
Department of Medical Biology and Central Electron Microscope Laboratory gyorgy.setalo.jr@aok.pte.hu
1 credit ▪ midsemester grade ▪ Elective subject for the Medical-biological module ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 12 lectures + 0 practices + 0 seminars = total of 12 hours
Course headcount limitations (min.-max.): 5 – 25 Prerequisites: OPO-GL1-T completed + OPO-G2B-T parallel
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
The topics of signal transduction will be discussed beyond the details of the compulsory course, Molecular cell biology 2. In 14 x 45
minutes special attention is paid to mechanisms that are relevant to diseases.
The course is recommended to those students who are especially interested in the signaling aspects of pathological processes.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Two multiple-choice test-exams, with 20-25 questions each, one halfway and another one at the end of the course.
Making up for missed classes
It is not possible to make up for missed classes.
Reading material
- Obligatory literature
- Literature developed by the Department
Lecturers using ppt will load these up onto the intranet after their class.
- Notes
- Recommended literature
Lectures
1 The protein kinase A system.
Dr. Sétáló György
2 Signaling in infectious diseases (cholera, pertussis and anthrax).
Dr. Palkovics Tamás
3 Growth factor signaling.
Dr. Sétáló György
4 Signaling through cell-cell and cell-matrix connections.
Dr. Sétáló György
5 First test.
Dr. Sétáló György
6 Stress signaling.
Dr. Bátor Judit
7 Signaling and inflammation.
Dr. Mikó Éva
8 Signaling of apoptosis.
Dr. Pap Marianna
9 Steroid signaling.
Dr. Sétáló György
10 Integrin signaling and metastasis.
Dr. Berta Gergely
11 Signaling gone wrong in the developing nervous system.
Dr. Ábrahám Hajnalka Gabriella
12 Second test.
Dr. Sétáló György
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Practices
Seminars
Exam topics/questions
Multiple-choice test questions based on the actually presented materials of the course.
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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OPF-H2A-T MEDICAL HUNGARIAN 2A - COMMUNICATION SKILLS
Course director: DR. VILMOS WARTA, associate professor
Department of Languages for Specific Purposes vilmos.warta@aok.pte.hu
2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 0 lectures + 0 practices + 24 seminars = total of 24 hours
Course headcount limitations (min.-max.): 2 – 25 Prerequisites: OPF-H1A-T completed + OPF-H2B-T parallel
Topic
This course is meant to serve as a transition between general and specific (doctor-patient) communication skills development.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Making up for missed classes
In the case of absences up to 25% of total class time, oral examination will have to be taken.
Reading material
- Obligatory literature
Anamnézis magyarul (Magyar orvosi szaknyelv kezdőknek) by Renáta Halász, 2015. Pécs
- Literature developed by the Department
http://aok.pte.hu/index.php?page=egyseg&egy_id=60&nyelv=eng&menu=okt_anyag
- Notes
http://aok.pte.hu/index.php?page=egyseg&egy_id=60&menu=okt_anyag&nyelv=eng
- Recommended literature
Lectures
Practices
Seminars
1 Logical relations, comparison
2 Logical relations, comparison
3 Giving orientation, informing people
4 Giving orientation, informing people
5 Giving descriptions, requesting and providing information
6 Giving descriptions, requesting and providing information
7 Cause and consequence
8 Medication and effects
9 Narratives
10 Narratives
11 Giving advice
12 Giving advice
13 Expressing uncertainty
14 Expressing uncertainty
15 Test 1
16 Test 1
17 Descriptions, warning
18 Descriptions, warning
19 Polite request, command and warning
20 Polite request, command and warning
21 Parts of the human body, pain, basic symptoms
22 Parts of the human body, pain, basic symptoms
23 History taking: presenting complaints, location, direction and character of pain
24 Test 2.
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Exam topics/questions
http://aok.pte.hu/index.php?page=egyseg&egy_id=60&menu=okt_anyag&nyelv=eng
Participants
Dávidovics Anna (U5A10Z), Dr. Hegedűs Anita (TQQEMK), Dr. Hild Gabriella (HILSWV), Dr. Németh Tímea (X8VRGN), Dr. Rébék-
Nagy Gábor (DGOZG1), Dr. Warta Vilmos (SJYRAV), Eklicsné Dr. Lepenye Katalin (JMXXSC), Krommer Zoltán (MQ5HNA),
Kurdiné Molnár Eszter (VUCECC), Nagy Gabriella (CYMRX3), Nagy Renáta (), Ronczykné Berta Anikó (CJZOFU), Szalai-Szolcsányi
Judit (RBGAPH), Szántóné Dr. Csongor Alexandra (UDKY0J)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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OPF-IZM-T MOLECULAR BASIS OF MUSCLE FUNCTION
Course director: DR. DÉNES LŐRINCZY, professor emeritus
Department of Biophysics denes.lorinczy@aok.pte.hu
2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours
Course headcount limitations (min.-max.): 1 – 30 Prerequisites: none
Topic
The structure of muscle based on light, phase contrast, polarized and electron microscopic observations. Elastic behaviour of passive and
active muscle, types of muscle contractions, muscle force-length relationship. Work done by the muscle, muscle efficiency and heat
production. Thermoelastic behaviour of muscle. Muscle models based on mechanical and structural investigations. Bioelectrical
phenomena, excitation-contraction coupling. Energetics of muscle function, structure of muscle proteins (actin, myosin etc.), analysis of
sliding model. Energetic and spectroscopic investigations in the research of molecular dynamic and thermodynamic background of
muscle function.
Conditions for acceptance of the semester
The applicants - in the case of more than one absence (up to maximum three absences in which must not be the consultation or test) -
should prepare and will be tested from the missed topics given by the instructor. In the case of more than three absences the course can
not be accepted.
Mid-term exams
Written test at the end of semester.
Making up for missed classes
The applicants - in the case of more than one absence (up to maximum three absences in which must not be the consultation or test) -
should prepare and will be tested from the missed topics given by the instructor.
Reading material
- Obligatory literature
- Literature developed by the Department
It will be announced at the beginning of the course depending on the possibilities of libraries of Biophysical Department, Faculty of
Medicine. A permanent source could be the roaming in the Internet.
- Notes
- Recommended literature
Lectures
1 The composition of muscle.
Dr. Lőrinczy Dénes
2 The sorts of muscle.
Dr. Lőrinczy Dénes
3 The structure of muscle on the basis of light, phasecontrast and polarization microscope.
Dr. Lőrinczy Dénes
4 Structure of muscle by ELMI.
Dr. Lőrinczy Dénes
5 Sorts of muscle contraction.
Dr. Lőrinczy Dénes
6 Elastic behaviour of passive and active muscle.
Dr. Lőrinczy Dénes
7 Muscle force and length relationship, Hill`s equation.
Dr. Lőrinczy Dénes
8 Work and heat production done by a muscle, efficiency of muscle function.
Dr. Lőrinczy Dénes
9 Thermoelastic behaviour of muscle.
Dr. Lőrinczy Dénes
10 Muscle models proposed by mechanical and structural investigations.
Dr. Lőrinczy Dénes
11 Biochemical basis and energetics of muscle function.
Dr. Lőrinczy Dénes
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12 Bioelectrical phenomena. Action potentials.
Dr. Lőrinczy Dénes
13 Nernst equation, G-H-K equation.
Dr. Lőrinczy Dénes
14 Voltage- and patch-clamp techniques.
Dr. Lőrinczy Dénes
15 Excitation-contraction coupling.
Dr. Lőrinczy Dénes
16 Structure of muscle proteins (actin and myosin, actomyosin complex).
Dr. Lőrinczy Dénes
17 Discussion of sliding model in details (x-ray diffraction).
Dr. Lőrinczy Dénes
18 Molecular dynamic background of muscle contraction (EPR spectroscopy)
Dr. Lőrinczy Dénes
19 Muscle in the sport and rehabilitation (wellness).
Dr. Lőrinczy Dénes
20 Principle of differential scanning calorimetry.
Dr. Lőrinczy Dénes
21 Thermodynamic background of muscle contraction (DSC results)
Dr. Lőrinczy Dénes
22 Muscle and levers in locomotion.
Dr. Lőrinczy Dénes
23 Written test.
Dr. Lőrinczy Dénes
24 Written test.
Dr. Lőrinczy Dénes
Practices
Seminars
Exam topics/questions
Written test
Participants
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OPF-XC1-T EXTRACELLULAR VESICLES: BASICS, ISOLATION AND APPLICATION METHODS 1
Course director: DR. KRISZTIÁN KVELL, associate professor
Department of Pharmaceutical Biotechnology kvell.krisztian@pte.hu
2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 20 Prerequisites: OPO-GL1-T completed
Topic
The course provides basic knowledge of different subtypes of extracellular vesicles. It gives a historical overview and detailed role in
physiological processes. Also covers the content and major components of extracellular vesicles. Besides overall theoretical background
of the field, the course gives ability to understand the challenges in different kind of isolation methods. Gives insight into current
application methodologies and future perspectives in the research field. Also highlights several possible molecular mechanisms
modulated by exosomes. The second part of the course mainly focuses on exosomes and their practical applications.
Topics:
- Basics of extracellular vesicles
- History of extracellular vesicles
- Biogenesis and release of extracellular vesicles
- Mechanisms of extracellular vesicle uptake
- Protein content of extracellular vesicles
- RNA content of extracellular vesicles
- Lipid content of extracellular vesicles
- Isolation methods for extracellular vesicles (overview)
- Technical challenges of working with extracellular vesicles
- Exosome isolation techniques from cell culture media
- Isolation of exosomes with differential ultracentrifugation
- Exosome isolation from blood plasma and serum
- Commercial kit based isolation of exosomes
- Minimal requirements for characterization of isolated extracellular vesicles
- Current trends in EV research
- Role of exosomes during aging
- Role of exosomes during tumor development
- Exercise derived exosomes
- Exam
Skills:
The student will have the following skills:
- basic and overall knowledge of extracellular vesicles
- apply different type of isolation methods of extracellular vesicles
- comprehend/resolve pitfalls and challenges of purification and isolation of extracellular vesicles
- apply extracellular vesicle point of view on research field of interest
- plan experiments in research field of interest
- get familiar with current research areas related to extracellular vesicles
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Grade based on written tests of semester
Making up for missed classes
Attending the course classes is obligatory.
Reading material
- Obligatory literature
Winston Patrick Kuo, Shidong Jia: Extracellular Vesicles: Methods and Protocols, Springer New York, 2017, ISBN 1493972510,
9781493972517
- Literature developed by the Department
Lecture materials will be published after the class
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- Notes
Student notes on lectures
- Recommended literature
Ramirez, M. I., Amorim, M. G., Gadelha, C., Milic, I., Welsh, J. A., Freitas, V. M., et al. (2018). Technical challenges of working
with extracellular vesiclesvesicles. Nanoscale. 881-906. doi:10.1039/c7nr08360b.
Lectures
1 Basics of extracellular vesicles
Bánfai Krisztina
2 History of extracellular vesicles
Bánfai Krisztina
3 Biogenesis and release of extracellular vesicles
Garai Kitti
4 Mechanisms of extracellular vesicle uptake
Garai Kitti
5 Protein content of extracellular vesicles I.
Bánfai Krisztina
6 Protein content of extracellular vesicles II.
Bánfai Krisztina
7 RNA content of extracellular vesicles I.
Garai Kitti
8 RNA content of extracellular vesicles II.
Garai Kitti
9 Lipid content of extracellular vesicles I.
Bánfai Krisztina
10 Lipid content of extracellular vesicles II.
Bánfai Krisztina
11 Isolation methods for extracellular vesicles (overview)
Garai Kitti
12 Technical challenges of working with extracellular vesicles
Garai Kitti
13 Exosome isolation techniques from cell culture media
Bánfai Krisztina
14 Isolation of exosomes with differential ultracentrifugation
Bánfai Krisztina
15 Exosome isolation from blood plasma and serum
Garai Kitti
16 Commercial kit based isolation of exosomes
Garai Kitti
17 Minimal requirements for characterization of isolated extracellular vesicles I.
Garai Kitti
18 Minimal requirements for characterization of isolated extracellular vesicles II.
Garai Kitti
19 Current trends in EV research I.
Bánfai Krisztina
20 Current trends in EV research II.
Bánfai Krisztina
21 Role of exosomes during aging I.
Dr. Kvell Krisztián
22 Role of exosomes during aging II.
Dr. Kvell Krisztián
23 Role of exosomes during tumor development I.
Dr. Pongrácz Judit Erzsébet
24 Role of exosomes during tumor development II.
Dr. Pongrácz Judit Erzsébet
25 Exercise derived exosomes I.
Dr. Kvell Krisztián
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26 Exercise derived exosomes II.
Dr. Kvell Krisztián
27 Exam
Bánfai Krisztina
28 Exam
Garai Kitti
Practices
Seminars
Exam topics/questions
At the last class oral test is held upon the exam questions provided during the semester.
Participants
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OPF-BMK-T METHODS AND EXPERIMENTS IN MOLECULAR BIOLOGY
Course director: DR. KATALIN SIPOS, associate professor
Department of Pharmaceutical Biology katalin.sipos@aok.pte.hu
1 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 0 lectures + 0 practices + 14 seminars = total of 14 hours
Course headcount limitations (min.-max.): 5 – 25 Prerequisites: none
Topic
We will analyze famous and interesting molecular biological experiments and examine the development and everyday importance of
methods used in molecular biology. We will pay special attention for experimental areas of pharmaceutical research. We hope the course
material will help the students to develop problemsolving thinking.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
The course will end with a written exam.
Making up for missed classes
According to personal agreement
Reading material
- Obligatory literature
- Literature developed by the Department
Scientific articles in English
- Notes
- Recommended literature
Lectures
Practices
Seminars
1 Methods to follow replication.
2 Molecular biological methods of cell cycle examinations
3 PCR
4 Array methods
5 Blotting methods
6 Labeling methods in the molecular biology
7 Gene regulation in the prokaryotes
8 Gene regulation in the eukaryotes.
9 Genetically modified animals
10 Experimental planning in pharmaceutical research I.
11 Experimental planning in pharmaceutical research II.
12 Real time PCR
13 Methods in cell culture experiments
14 Exam
Exam topics/questions
No extra exam questions. The basis of the exam is the material of the seminars.
Participants
Dr. Pandur Edina (ZP0077), Dr. Poór Viktor Soma (SA17J1), Dr. Sipos Katalin (RUHPLE), Jánosa Gergely (U3SEOW), Pap Ramóna
(OGEM0W)
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OPF-H2B-T MEDICAL HUNGARIAN 2B - LANGUAGE POINTS
Course director: DR. VILMOS WARTA, associate professor
Department of Languages for Specific Purposes vilmos.warta@aok.pte.hu
2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 0 lectures + 0 practices + 24 seminars = total of 24 hours
Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPF-H1B-T completed + OPF-H2A-T parallel
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
This course is meant to provide the language basis for advanced communication between doctors and patients.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Making up for missed classes
To be discussed with the course tutor.
Reading material
- Obligatory literature
Anamnézis magyarul (Magyar orvosi szaknyelv kezdőknek) by Renáta Halász, 2015. Pécs
- Literature developed by the Department
http://aok.pte.hu/index.php?page=egyseg&egy_id=60&nyelv=eng&menu=okt_anyag
- Notes
- Recommended literature
Lectures
Practices
Seminars
1 Expressing possessing, genitive case
2 Expressing possessing, genitive case
3 Adjectives and nouns: eg. nátha-náthás, nominalization: eg köhög-köhögés
4 Adjectives and nouns: eg. nátha-náthás, nominalization: eg köhög-köhögés
5 Question words, concerning time and location and adverbs of time
6 Question words, concerning time and location and adverbs of time
7 Expressing cause, giving explanation
8 Expressing cause, giving explanation
9 Functions of past tense in medical Hungarian
10 Functions of past tense in medical Hungarian
11 Future tense, modality expressing ability and volition
12 Future tense, modality expressing ability and volition
13 Impersonalization
14 Impersonalization
15 Consolidation test 1
16 Test 1
17 Modality expressing necessity, possibility and prohibition
18 Modality expressing necessity, possibility and prohibition
19 Definite and indefinite conjugation, prefixed verbs
20 Definite and indefinite conjugation, prefixed verbs
21 Imperative forms
22 Imperative forms
23 Giving instructions to patients
24 Test 2.
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Exam topics/questions
http://aok.pte.hu/index.php?page=egyseg&egy_id=60&menu=okt_anyag&nyelv=eng
Participants
Dávidovics Anna (U5A10Z), Dr. Hegedűs Anita (TQQEMK), Dr. Hild Gabriella (HILSWV), Dr. Németh Tímea (X8VRGN), Dr. Rébék-
Nagy Gábor (DGOZG1), Dr. Warta Vilmos (SJYRAV), Eklicsné Dr. Lepenye Katalin (JMXXSC), Krommer Zoltán (MQ5HNA),
Kurdiné Molnár Eszter (VUCECC), Nagy Gabriella (CYMRX3), Nagy Renáta (), Ronczykné Berta Anikó (CJZOFU), Szalai-Szolcsányi
Judit (RBGAPH), Szántóné Dr. Csongor Alexandra (UDKY0J)
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OPF-MGY-T MEDICINAL PLANTS IN THE MECSEK MOUNTAIN - FIELD STUDY 1
Course director: DR. NÓRA PAPP, associate professor
Department of Pharmacognosy nora4595@gamma.ttk.pte.hu
2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 12 lectures + 12 practices + 0 seminars = total of 24 hours
Course headcount limitations (min.-max.): 5 – 15 Prerequisites: none
Topic
The course includes 6x2 lectures and 3x4 practice (field work). The aim of the course is to practice the correct identification of medicinal
plants, knowledge of main morphological characters, habitat, collection place, and therapeutical use. The course gives a general overview
on the most frequent medicinal plants, protected and produced species, as well as various vegetation types in the Mecsek mountain and
its environment. In addition, the effect and relationship between abiotic factors and secondary metabolites of plants are also discussed,
which can provide recommendations for collection place and habitat of plants.
Conditions for acceptance of the semester
Maximal absences: 2 /semester.
Mid-term exams
Fulfillment of 2 tests.
Making up for missed classes
http://gytk.pte.hu/en/egyseg/oktatasianyagok/1640
http://aok.pte.hu/en/egyseg/oktatasianyagok/1640
Reading material
- Obligatory literature
- Literature developed by the Department
Lectures downloaded in Neptun.
- Notes
- Recommended literature
Lectures
1 Vegetation types of medicinal plants; ecological factors in habitats I
Dr. Papp Nóra
2 Vegetation types of medicinal plants; ecological factors in habitats I
Dr. Papp Nóra
3 Vegetation types of medicinal plants; ecological factors in habitats II
Dr. Papp Nóra
4 Vegetation types of medicinal plants; ecological factors in habitats II
Dr. Papp Nóra
5 Environmental adaptation of medicinal plants (morphology, phytochemistry); relationship between medicinal plant populations
and their environment
Dr. Papp Nóra
6 Environmental adaptation of medicinal plants (morphology, phytochemistry); relationship between medicinal plant populations
and their environment
Dr. Papp Nóra
7 Vegetation types in the Mecsek mountain I: medicinal plants in beech and karst shrub forests
Dr. Papp Nóra
8 Vegetation types in the Mecsek mountain II: medicinal plants in rock grasses, swamps and alder woods
Dr. Papp Nóra
9 Medicinal plants at road edge vegetations, planted and protected plants of the Mecsek mountain I
Dr. Papp Nóra
10 Medicinal plants at road edge vegetations, planted and protected plants of the Mecsek mountain II
Dr. Papp Nóra
11 Identification of medicinal plants used Identification Handbooks, methods in field work I
Dr. Papp Nóra
12 Identification of medicinal plants used Identification Handbooks, methods in field work II
Dr. Papp Nóra
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56
Practices
1 Identification of medicinal plants in rock grasses (Tettye)
2 Identification of medicinal plants in rock grasses (Tettye)
3 Identification of medicinal plants in rock grasses (Tettye)
4 Identification of medicinal plants in rock grasses (Tettye)
5 Identification of medicinal plants in oak forest (Dömörkapu)
6 Identification of medicinal plants in oak forest (Dömörkapu)
7 Identification of medicinal plants in oak forest (Dömörkapu)
8 Identification of medicinal plants in oak forest (Dömörkapu)
9 Identification of medicinal plants in swamp (Pellérd)
10 Identification of medicinal plants in swamp (Pellérd)
11 Identification of medicinal plants in swamp (Pellérd)
12 Identification of medicinal plants in swamp (Pellérd)
Seminars
Exam topics/questions
According to the topics of the course.
Participants
Dr. Papp Nóra (S3PA4G)
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OPF-PLH-T THE PLACEBO EFFECT
Course director: TIBOR SZOLCSÁNYI, assistant professor
Department of Behavioural Sciences tibor.szolcsanyi@aok.pte.hu
1 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 12 lectures + 0 practices + 0 seminars = total of 12 hours
Course headcount limitations (min.-max.): 5 – 50 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
The use of placebo effect has been an inherent part of medicine for thousands of years, and in the recent decades it has become an
inevitable element of medical research due to the introduction of placebo controlled clinical trials. In spite of this fact the research
methodology to measure the effectiveness of placebo effect has been clarified only in the last 10-15 years. At the same time researches
on the neurochemical mechanisms underlying the placebo effect have gained a new impetus. Currently, therefore, we have a much greater
understanding of placebo effect in the context of evidence-based medicine than before, which raises new types of ethical questions as
well. During the course we will examine the different aspects of the phenomenon of placebo effect, and the students will gain knowledge
of the current research results on the field. The main topics of the course: the history of the use of placebo therapies, the role of placebo
effect in medical research, the psycho-social factors that are able to induce placebo effect, neurochemical mechanisms underlying the
placebo effect, the ethical implications of the use of placebo effect in medical treatments.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Written test taking place in the last class. To improve the grade, the test can be repeated two times in the first two weeks of the exam
period.
Making up for missed classes
According to the Code of Studies and Examinations.
Reading material
- Obligatory literature
Franklin G. Miller; Luna Colloca; Ted J. Kaptchuk: The Placebo Effect: Illness and Interpersonal Healing, Perspect Biol Med. 2009
; 52(4)
Damien G. Finniss; Ted J. Kaptchuk; Franklin G. Miller; Fabrizio Benedetti: Biological, Clinical and Ethical Advances of Placebo
Effects, Lancet 2010; 375; 686-695
Franklin G. Miller; Donald L. Rosenstein: The Nature and Power of the Placebo Effect, Journal of Clinical Epidemiology 59, 2006;
331-335
Fabrizio Benedetti: Mechanisms of Placebo and Placebo-Related Effects across Diseases and Treatments, Annual Review of
Pharmacology and Toxicology, Vol. 48; 2008; 33-60.
Jozien M. Bensing; William Verheul: The Silent Healer: The Role of Communication in Placebo Effects, Patient Education and
Counseling 80, 2010; 293-299
- Literature developed by the Department
Additional materials: Neptun MeetStreet
- Notes
--
- Recommended literature
Fabrizio Benedetti: Placebo Effect, Oxford University Press, Oxford, 2009
Lectures
Lectures
1 Introduction, definitions of placebo effect
Dr. Szolcsányi Tibor
2 The use of placebo effect in the history of medicine
Dr. Szolcsányi Tibor
3 The use of placebo effect in the context of medical research: the introduction of randomized placebo controlled clinical trials and
its consequences
Dr. Szolcsányi Tibor
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4 The methodological and ethical challenges of placebo research
Dr. Szolcsányi Tibor
5 The main forms of placebo effect (expectancy based / classical conditioning / affective modulation) and their effectiveness in
different diseases
Dr. Szolcsányi Tibor
6 The neurochemistry of placebo effect: placebo analgesia
Dr. Szolcsányi Tibor
7 The neurochemistry of placebo effect: the cardiovascular and the respiratory system, immune response and hormone secretion,
Parkinson disease
Dr. Szolcsányi Tibor
8 The neurochemistry of placebo effect: further results
Dr. Szolcsányi Tibor
9 An overview of the psycho-social factors that are able to induce placebo effect
Dr. Szolcsányi Tibor
10 Pain management through psychological interventions and placebo analgesia
Dr. Szolcsányi Tibor
11 Ethical implications: how to enhance the placebo effect through improving the physician-patient relationship
Dr. Szolcsányi Tibor
12 Written test
Dr. Szolcsányi Tibor
Practices
Seminars
Exam topics/questions
--
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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OPF-VVE-T VACCINATION, ANTI-VACCINATION MOVEMENTS: DO MORE HARM THAN GOOD
Course director: DR. KATALIN SZENDI, assistant professor
Department of Public Health Medicine szkata82@yahoo.co.uk
1 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 12 lectures + 0 practices + 0 seminars = total of 12 hours
Course headcount limitations (min.-max.): 5 – 30 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
Vaccination belongs to one of the most successful modern health care programmes that decreased significantly the number of severe
infectious diseases. In today’s world experts are unable to compete with the media. Several delusions circulate infiltrating the public
opinion related to vaccines. The most susceptible target audience of these beliefs are the half-educated laymen who believe in the media
created pseudoscience. The activity of stubborn anti-vaccine minorities can be dangerous because that may open up new chances of the
spread of infectious diseases.
The objective of the course is to deepen the knowledge of vaccinations concerning the background, benefits, achievements and failures,
and the course also serves as a thought provoking initiation for practitioners relating to possible actions against the anti-vaccination
movements.
Conditions for acceptance of the semester
Participation in lectures and practicals is obligatory which is registered.
Absences should not exceed 15% (2x45 min). Otherwise signature of grade book is denied.
Mid-term exams
Making up for missed classes
There are no make-up classes.
Reading material
- Obligatory literature
- Literature developed by the Department
Educational material uploaded on Neptun.
- Notes
- Recommended literature
Stanley A. Plotkin. History of Vaccine Development. Springer 2011.
Vaccine Fact Book 2013. http://www.phrma.org/sites/default/files/pdf/PhRMA_Vaccine_FactBook_2013.pdf
WHO, UNICEF, World Bank. State of the world’s vaccines and immunization, 3rd ed., Geneva, World Health Organization, 2009.
Lectures
1 History of vaccines and anti-vaccination movements
Dr. Szendi Katalin
2 Epidemiology of infectious diseases, morbidity and mortality rates before and after vaccine introduction. Is there any benefit of
vaccination?
Dr. Szendi Katalin
3 Epidemiological studies on vaccination, are there any at all?
Dr. Szendi Katalin
4 Morbidity, mortality, incidence, prevalence. Statistics, data availability, official sources. Are there enough and reliable data to
prove the effectiveness or safety of vaccines?
Dr. Szendi Katalin
5 Groups of vaccinations. Why are they compulsory?
Dr. Szendi Katalin
6 Types of vaccinations. Are there any unnecessary ones (e.g. BCG)? Is it possible that the only purpose of the pharmaceutical
industry is to increase their profits?
Dr. Szendi Katalin
7 The function of vaccination, types of immunity. Is artificial induction of immunity good for our immune system? Does it result
in more benefits if the diseases are fought off in a natural way?
Dr. Szendi Katalin
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8 The efficiency of vaccines. Do the European countries with better health indicators also have better epidemiological situation
than Hungary? Questions of herd immunity.
Dr. Szendi Katalin
9 Vaccine effectiveness. Are there any positive health effects, or just does the government want to make us believe in counterfeit
statistical data?
Dr. Szendi Katalin
10 Vaccination safety, components. Are the ingredients in vaccines dangerous? Do they cause any harm to health? Diversity of
conspiracy theories
Dr. Szendi Katalin
11 Risks of vaccines, vaccination health hazards. Do the vaccines do more harm than good? MMR and autism. Mercury and autism.
Aluminium and autism.
Dr. Szendi Katalin
12 Anti-vaccination activities in Hungary and abroad
Dr. Szendi Katalin
Practices
Seminars
Exam topics/questions
Neptun
Participants
Dr. Szendi Katalin (MRDJ71)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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OPF-BAL-T MINERAL AND SPA WATERS, BALNEOLOGY
Course director: DR. CSABA VARGA, professor
Department of Public Health Medicine chemsafety@freemail.hu
2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 2
Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours
Course headcount limitations (min.-max.): 5 – 40 Prerequisites: none
Topic
The main educational task of the subject initiating to form state-of-art regarding use and application of mineral and spa waters in Hungary
and EU with special respect of the prevention.
Short description of the course: Delivering up to date hydrological, hydrogeological, physical, chemical, biological knowledge for
students of medicine and other sciences.
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
Making up for missed classes
Reading material
- Obligatory literature
- Literature developed by the Department
Neptun
- Notes
- Recommended literature
Lectures
1 Hydrogeology and balneology of mineral and spa waters
Márovics Gergely Péter
2 Hydrogeology of Hungarian mineral and spa waters
Márovics Gergely Péter
3 Correlation of the geological characteristics and the chemical composition
Bérczi Bálint Dániel
4 Hydrology of mineral and spa waters
Bérczi Bálint Dániel
5 Mineral and spa waters in Hungary and Europe
Dr. Varga Csaba
6 Chemical characteristics of mineral and spa waters
Dr. Varga Csaba
7 Inorganic analytical classification. Presence of microelements
Dr. Varga Csaba
8 Inorganic ions, substances an compexes in the therapeutical effect
Dr. Varga Csaba
9 Organic ions, substances and complexes in the therapeutical
Dr. Varga Csaba
10 In situ water analysis. Inorganic analysis
Dr. Varga Csaba
11 Hygienic microbiological analysis
Dr. Varga Csaba
12 Arteficial mineral and medicinal waters
Dr. Varga Csaba
13 Peloids: genesis, chemical/physical/toxicological properties. Hungarian peloids.
Dr. Varga Csaba
14 Mineral and spa water products
Dr. Varga Csaba
15 Introduction to Balneology: objectives and history
Dr. Varga Csaba
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16 Water and ions in the human body
Dr. Varga Csaba
17 External cure with spa waters, mode of action
Dr. Varga Csaba
18 Mechanic, thermal, chemical and psychic actions, Spa reaction
Dr. Varga Csaba
19 Water types in cure
Dr. Varga Csaba
20 Application of spa waters to different diseases
Dr. Varga Csaba
21 Therapeutic applications of peloids
Dr. Varga Csaba
22 Internal use of mineral and medicinal waters, Drinking cure
Dr. Varga Csaba
23 Inhalation cure.
Dr. Varga Csaba
24 Other natural cures: climate cure, physicotherapy, additional therapies
Dr. Varga Csaba
Practices
Seminars
Exam topics/questions
Neptun
Participants
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OPE-TSA-T STATISTICAL ANALYSIS OF THESIS AND STUDENT RESEARCH PROJECTS
Course director: DR. KORNÉLIA FARKAS-BORBÁS, assistant professor
Institute of Bioanalysis nelli.farkas@aok.pte.hu
1 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ both semesters ▪ recommended semester: 3
Number of hours/semester: 6 lectures + 6 practices + 0 seminars = total of 12 hours
Course headcount limitations (min.-max.): 3 – 20 Prerequisites: none
Topic
This course is for those students who are working on a student research plan or working on their thesis. They can process their own data
and learn the theory of the applied statistical methods as well.
Conditions for acceptance of the semester
Problem solving, oral report
Mid-term exams
Making up for missed classes
Consultation
Reading material
- Obligatory literature
- Literature developed by the Department
Own database
- Notes
- Recommended literature
Andrew F. Siegel: Statistics and Data Analysis. An introduction, John Wiley & Sons, 1988
Douglas G. Altman: Practical Statistics for Medical Research, Chapman & Hall, 1994
P. Armitage and G. Berry: Statistical Methods in Medical Research, Blackwell Science, 1994
Robert R. Sokal / F. James Rohlf: Biometry, W. H. Freeman and Company, New York, 1981
Lectures
1 Set the data and complete the database for statistical processing
Borbásné Dr. Farkas Kornélia
2 Select the right statistical methods
Dr. Pótó László
3 Learn the theory of the selected methods
Dr. Pótó László
4 Interpret the results
Borbásné Dr. Farkas Kornélia
5 Interpret the results
Borbásné Dr. Farkas Kornélia
6 Conclusions
Borbásné Dr. Farkas Kornélia
Practices
1 Set the data and complete the database for statistical processing
2 Select the right statistical methods
3 Learn the theory of the selected methods
4 Learn the theory of the selected methods
5 Interpret the results
6 Interpret the results
Seminars
Exam topics/questions
Participants
Borbásné Dr. Farkas Kornélia (IRWZKJ)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
64
OPE-WMI-T WEAK MOLECULAR INTERACTIONS
Course director: DR. SÁNDOR KUNSÁGI-MÁTÉ, associate professor
Department of Pharmaceutical Chemistry kunsagi-mate.sandor@gytk.pte.hu
2 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ both semesters ▪ recommended semester: 3
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 2 – 12 Prerequisites: OPA-GC1-T completed
Topic
Types of molecular interactions. Chemical equilibrium based on the weak molecular interactions. Determination of the chemical
equilibrium and the stoichiometry of the complexes. Correlation between the chemical equilibrium and the free enthalpy. Investigation
of the weak interaction by spectroscopical methods. Application of the Job’s method in the fluorescence measurements. Direct measuring
the interaction enthalpy by differential scanning calorimetry. Interactions of aromatic compounds. Interactions of antibiotics with
membrane elements. Interactions of bioactive molecules with DNA. Investigations of model-systems: interactions of calixarenes with
phenols and fullerenes. Packing of drug molecules by molecular containers. Interactions of bioactive molecules with elements of cell
membranes. Self-assembly of some hormones by weak interactions.
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
One written exam during the semester, the acceptance level is 60%.
Making up for missed classes
There is no possibility to make up for a missed lecture and practice
Reading material
- Obligatory literature
David Freifelder: Physical Biochemistry
- Literature developed by the Department
Shyllabus and ppt presentation is available.
- Notes
- Recommended literature
Atkins: Physical Chemistry I-III.
David Freifelder: Physical Biochemistry
Lectures
1 Types of molecular interactions.
Dr. Kunsági-Máté Sándor
2 Types of molecular interactions.
Dr. Kunsági-Máté Sándor
3 Chemical equilibrium based on the weak molecular interactions.
Dr. Kunsági-Máté Sándor
4 Chemical equilibrium based on the weak molecular interactions.
Dr. Kunsági-Máté Sándor
5 Determination of the chemical equilibrium and the stoichiometry of the complexes.
Dr. Kunsági-Máté Sándor
6 Determination of the chemical equilibrium and the stoichiometry of the complexes.
Dr. Kunsági-Máté Sándor
7 Correlation between the chemical equilibrium and the free enthalpy.
Dr. Kunsági-Máté Sándor
8 Correlation between the chemical equilibrium and the free enthalpy.
Dr. Kunsági-Máté Sándor
9 Investigation of the weak interaction by measuring the fluorescence.
Dr. Kunsági-Máté Sándor
10 Investigation of the weak interaction by measuring the fluorescence.
Dr. Kunsági-Máté Sándor
11 Application of the Job’s method in the fluorescence measurements.
Dr. Kunsági-Máté Sándor
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
65
12 Application of the Job’s method in the fluorescence measurements.
Dr. Kunsági-Máté Sándor
13 Direct measuring the interaction enthalpy by differential scanning calorimetry.
Dr. Kunsági-Máté Sándor
14 Direct measuring the interaction enthalpy by differential scanning calorimetry.
Dr. Kunsági-Máté Sándor
15 Interactions of aromatic compounds. Interactions of bioactive compounds with DNA.
Dr. Kunsági-Máté Sándor
16 Interactions of aromatic compounds. Interactions of bioactive compounds with DNA.
Dr. Kunsági-Máté Sándor
17 Investigations of model-systems: interactions of calixarenes with phenols and fullerenes.
Dr. Kunsági-Máté Sándor
18 Investigations of model-systems: interactions of calixarenes with phenols and fullerenes.
Dr. Kunsági-Máté Sándor
19 Investigations of the conformation changes of proteins by fluorescence and calorimetric methods.
Dr. Kunsági-Máté Sándor
20 Investigations of the conformation changes of proteins by fluorescence and calorimetric methods.
Dr. Kunsági-Máté Sándor
21 Investigations of the conformation changes of proteins by fluorescence and calorimetric methods.
Dr. Kunsági-Máté Sándor
22 Controlling of self-assembly of some hormones by weak interactions.
Dr. Kunsági-Máté Sándor
23 Controlling of self-assembly of some hormones by weak interactions.
Dr. Kunsági-Máté Sándor
24 Controlling of self-assembly of some hormones by weak interactions.
Dr. Kunsági-Máté Sándor
25 Modifications of structure of serum albumins by molecular capsules. Interactions of molecular capsules with aromatic amino
acids at terminated positions.
Dr. Kunsági-Máté Sándor
26 Effect of Molecular Environment on the Formation Kinetics of Complexes of Malvidin-3-O-glucoside with Caffeic Acid and
Catechin
Dr. Kunsági-Máté Sándor
27 Competitive hydrogen bonds associated with the effect of primycin antibiotic on oleic acid as a building block of plasma
membranes.Complex formation between primycin and ergosterol: entropy - driven initiation of modification of the fungal plasma
membrane structure
Dr. Kunsági-Máté Sándor
28 Role of the Conformational Freedom of the Skeleton in the Complex Formation Ability of Resorcinarene Derivatives toward a
Neutral Phenol Guest
Dr. Kunsági-Máté Sándor
Practices
Seminars
Exam topics/questions
Types of molecular interactions.
Chemical equilibrium based on the weak molecular interactions.
Determination of the chemical equilibrium and the stoichiometry of the complexes.
Correlation between the chemical equilibrium and the Gibbs free energy.
Investigation of the weak interaction by spectroscopical methods.
Application of the Job”s method in the fluorescence measurements.
Direct measuring the interaction enthalpy by differential scanning calorimetry.
Interactions of aromatic compounds.
Interactions of bioactive compounds with DNA.
Investigations of model-systems: interactions of calixarenes with phenols and fullerenes.
Packing of drug molecules by molecular containers.
Interactions of bioactive molecules with elements of cell membranes.
Self-assembly of some hormones by weak interactions.
Participants
Dr. Kunsági-Máté Sándor (UYZM2Q)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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OPE-TSS-T MEDICAL APPLICATIONS OF MASS SPECTROMETRY
Course director: DR. LÁSZLÓ MÁRK, associate professor
Department of Biochemistry and Medical Chemistry laszlo.mark@aok.pte.hu
2 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ autumn semester ▪ recommended semester: 3
Number of hours/semester: 20 lectures + 0 practices + 0 seminars = total of 20 hours
Course headcount limitations (min.-max.): 3 – 50 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
In medical sciences, emphasis is increasingly placed on instrumental techniques and accurate, quantitative measurements. This course is
give an overall review about the modern mass spectrometry and it shows the medical applications of the MS in the clinical and diagnostic
practice.
Topics:
Introduction to MS. Ionsources, analizators, detectors. Separation techniques. Sample handling. Biomedical sampling. Bioinformatics.
Proteomics, metabolomics and lipidomics. Biomarker discovery. Mass spectrometric imaging techniques.
Conditions for acceptance of the semester
Written exam. Max. absences: 20%.
Mid-term exams
Not possible.
Making up for missed classes
Not possible.
Reading material
- Obligatory literature
- Literature developed by the Department
Lecture slides and notes.
- Notes
- Recommended literature
Vékey et al: Medical Applications of Mass Spectrometry, 2008.
Hoffman et al: Mass Spectrometry, 2007
Lectures
1 Introduction to mass spectrometry
Dr. Márk László
2 Introduction to mass spectrometry
Dr. Márk László
3 Ionsources
Dr. Márk László
4 Analyzers
Dr. Márk László
5 The mass spectrum.
Dr. Márk László
6 Sample matrices, Sampling procedures.
Dr. Márk László
7 Sample pretreatment, separation techniques.
Dr. Márk László
8 Sample pretreatment, separation techniques.
Dr. Márk László
9 Proteomics
Dr. Márk László
10 Proteomics
Dr. Márk László
11 Metabolomics
Dr. Márk László
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12 Metabolomics
Dr. Márk László
13 Investigation of endocrine system
Dr. Márk László
14 Investigation of endocrine system
Dr. Márk László
15 Pathological biomarker discovery
Dr. Márk László
16 Pathological biomarker discovery
Dr. Márk László
17 Lipidomics
Dr. Márk László
18 Lipidomics
Dr. Márk László
19 Imaging mass spectrometry
Dr. Márk László
20 Imaging mass spectrometry
Dr. Márk László
Practices
Seminars
Exam topics/questions
Ionsources.
Analizators.
Detectors.
Separation techniques.
Sample handling. Biomedical sampling.
Bioinformatics.
Proteomics.
Metabolomics
Lipidomics.
Biomarker discovery.
Mass spectrometric imaging techniques.
MS of endocrine system.
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
68
OPE-BEE-T BASICS OF EPIDEMIOLOGY
Course director: DR. TÍMEA VARJAS, assistant professor
Department of Public Health Medicine vtimi_68@yahoo.com
1 credit ▪ midsemester grade ▪ Elective subject for the Medical-biological module ▪ autumn semester ▪ recommended semester: 3
Number of hours/semester: 12 lectures + 0 practices + 0 seminars = total of 12 hours
Course headcount limitations (min.-max.): 1 – 20 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
During the semester students are acquainted with the basics of epidemiology and epidemiological studies frequently used in scientific
literature. With this knowledge one can easily elucidate and interpret scientific publications.
This course was established especially for pharmacist and dentist students.
Conditions for acceptance of the semester
Absences should not exceed 15% of lectures and practicals (2x45 min). Otherwise signature of grade book is denied.
Mid-term exams
Examination: written test
Making up for missed classes
Based on individual consideration
Reading material
- Obligatory literature
- Literature developed by the Department
PPT-presentations (Neptun)
- Notes
- Recommended literature
Lectures
1 The concept of epidemiology
Dr. Szabó István
2 The historical context
Dr. Szabó István
3 Epidemiology and public helath
Dr. Szabó István
4 Achievments in epidemiology
Dr. Szabó István
5 Measuring health and disease
Dr. Szabó István
6 Epidemiological studies
Dr. Szabó István
7 Epidemiological studies
Dr. Szabó István
8 Epidemiological studies
Dr. Szabó István
9 Potential errors in epidemiological studies
Dr. Szabó István
10 The concept of Evidence Based Medicine
Dr. Szabó István
11 Basic epidemiological calculations
Dr. Szabó István
12 Analyzis of selected scientific publications
Dr. Szabó István
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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Practices
Seminars
Exam topics/questions
Neptun
Participants
Dr. Szabó István (BF4MF6)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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OPE-EHS-T HUNGER, SATIETY AND DISTURBANCES OF BODY WEIGHT REGULATION
Course director: DR. LÁSZLÓ LÉNÁRD I, professor emeritus
Institute of Physiology laszlo.lenard@aok.pte.hu
1 credit ▪ midsemester grade ▪ Elective subject for the Medical-biological module ▪ autumn semester ▪ recommended semester: 3
Number of hours/semester: 12 lectures + 0 practices + 0 seminars = total of 12 hours
Course headcount limitations (min.-max.): 5 – 25 Prerequisites: OPO-Z2E-T completed + OPO-G2B-T completed
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
Based on recent results, feeding related physiological and pathophysiological mechanisms will be discussed. Students will be trained to
understand these mechanisms. The knowledge based on this course will highly contribute to better understanding further clinical studies
on human diseases.
Peripheral and central mechanisms of hunger, satiety, salt appetite and body weight regulation will be discussed. Lectures will include
the following topics: Neural and humoral processes. Peripheral and central glucose-monitoring system. The role of neuropeptides in the
control of feeding and hydromineral balance. Pathological processes: obesity, bulimia, anorexia.
Conditions for acceptance of the semester
Absence from no more than 25% of the lectures.
Mid-term exams
Written exams.
Making up for missed classes
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
Notes taken at the lectures.
- Recommended literature
Lectures
1 Basic parameters: caloric intake, energy expenditure, measurement of food and water intake, body weight and body mass index.
Body weight curves during development, adulthood and senescence.
Dr. Lénárd László I
2 Peripheral and central mechanisms of body weight regulation.
Dr. Lénárd László I
3 Endocrine mechanisms: the role of different hormones.
Dr. Lénárd László I
4 Body weight loss, obesity. Long run pathological consequences of obesity.
Dr. Lénárd László I
5 Hunger and satiety. Motivational mechanisms. Overeating, rejection.
Dr. Lénárd László I
6 Hypothalamic dual centers. The role of limbic system in hunger and satiety.
Dr. Lénárd László I
7 Peripheral glucose related signals. The central glucose monitoring system.
Dr. Lénárd László I
8 Food rewarded learning, the role of reinforcement. Aversive learning, the role of conditioned taste aversion in feeding habits.
Dr. Lénárd László I
9 The sight, odor, taste and texture of foods and their detection in the limbic system. Ingestive and rejective mimetic responses and
their genetic determination. The role of monoamines in the regulation of feeding. Similarities of food rewarded learning and
addictive behavior. The role of dopamine and neuropeptides.
Dr. Lénárd László I
10 Orexigenic and anorexigenic neuropeptides.
Dr. Lénárd László I
11 The role of the central angiotensinergic system in drinking and hydromineral balance.
Dr. Lénárd László I
12 Childhood obesity and cognitive processes. Anorexia nervosa, bulimia and binge eating. Clinical relevance of animal experiments
Dr. Lénárd László I
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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Practices
Seminars
Exam topics/questions
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
72
OPF-TG1-T STUDENT PROJECT RESEARCH FOR STUDENTS OF PHARMACEUTIST PROGRAMME 1
Course director: DR. GYÖRGYI HORVÁTH, associate professor
Department of Pharmacognosy gyorgyi.horvath@aok.pte.hu
2 credit ▪ midsemester grade ▪ Optional subject ▪ both semesters ▪ recommended semester: 3
Number of hours/semester: 0 lectures + 24 practices + 0 seminars = total of 24 hours
Course headcount limitations (min.-max.): 1 – 50 Prerequisites: none
Topic
The course aims at promoting of students to make student research projects on the field of pharmaceutical sciences. Furthermore, we
wish to give individual possibilities of students to perform experiments in the different pharmaceutical institutes involved into Students’
Research Society.
Conditions for acceptance of the semester
The continuous student’s work is recommended. The continuous enrollment of consecutive courses can be stopped and continued in
further semesters.
The prerequisite of this course (TDK 1): registration of the student in the database of Students’ Research Society.
Mid-term exams
- Topic plan of student’s research project with the confirmation of supervisor
- Introduction of scientific articles found by the student in databases
- The topic plan and articles must be sent for course supervisor at the end of 13th week of the semester.
Making up for missed classes
There is no possibility.
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
ScienceDirect database
Lectures
Practices
1-24 Research.
Seminars
Exam topics/questions
Not applicable.
Participants
Dr. Horváth Györgyi (GDLTCH)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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OPF-TMB-T MOLECULAR BIOLOGY OF TUMORS
Course director: DR. EDINA PANDUR, assistant professor
Department of Pharmaceutical Biology edina.pandur@aok.pte.hu
2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 3
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 3 – 30 Prerequisites: OPO-GL1-T completed + OPO-G2B-T completed
Topic
During the course we will discuss the molecular mechanisms of tumor development. We will deal with characteristic features of tumor
cells, and cancers. The function of influencing factors, risk factors, causes, the underlying molecular mechanisms, e.g. mutations, the
role of oncogenes and tumor-suppressor genes, DNA repair, epigenetics and the role of immune system will be discussed in detail. We
will emphasize the function of cell signaling pathways and the failure of apoptosis in tumorigenesis. We will speak about the molecular
mechanisms of invasion and metastasis of tumors, the genes and proteins which have a crucial role in these processes. The participants
will get an insight into the molecular diagnosis, genetic aberrations, and molecular alterations of human cancers. We will discuss the
possibilities for cancer therapies, the new approaches such as gene therapy and immunotherapy.
Conditions for acceptance of the semester
Max. 3 absences
Mid-term exams
One assay, one midterm exam.
Making up for missed classes
Personal consultation
Reading material
- Obligatory literature
- Literature developed by the Department
Educational materials will be uploaded to Neptune MeetStreet.
- Notes
- Recommended literature
Lauren Pecorino: Molecular Biology of Cancer
Wolfgang Arthur Schulz: Molecular Biology of Human Cancers
Lectures
1 Introduction to cancers: classification and characterization of cancers, causes of cancer, properties of cancer cells, principles of
therapies, targets of therapies
Dr. Pandur Edina
2 Introduction to cancers: classification and characterization of cancers, causes of cancer, properties of cancer cells, principles of
therapies, targets of therapies
Dr. Pandur Edina
3 Tumor genetics: mutations, carcinogenic agents, inheritance, tumor genes, defects in DNA repair and predispositions to cancer,
cell protection mechanisms
Dr. Pandur Edina
4 Tumor genetics: mutations, carcinogenic agents, inheritance, tumor genes, defects in DNA repair and predispositions to cancer,
cell protection mechanisms
Dr. Pandur Edina
5 Tumor epigenetics: mechanisms of epigenetic inheritance, imprinting, DNA methylation, epigenetics of cell differentiation and
tissue homeostasis
Dr. Poór Viktor Soma
6 Tumor epigenetics: mechanisms of epigenetic inheritance, imprinting, DNA methylation, epigenetics of cell differentiation and
tissue homeostasis
Dr. Poór Viktor Soma
7 Oncogenes and tumor-suppressor genes
Dr. Pandur Edina
8 Oncogenes and tumor-suppressor genes
Dr. Pandur Edina
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
74
9 The cell cycle, apoptosis and senescence: checkpoints, therapeutic targets and inhibitors, molecular mechanisms of apoptosis,
replicative senescence and its disturbances in human cancers
Pap Ramóna
10 The cell cycle, apoptosis and senescence: checkpoints, therapeutic targets and inhibitors, molecular mechanisms of apoptosis,
replicative senescence and its disturbances in human cancers
Pap Ramóna
11 Signaling pathways in tumors: MAPK, PI3K, TP53 network, NFkappaB, TGFbeta, STAT signaling
Dr. Pandur Edina
12 Signaling pathways in tumors: MAPK, PI3K, TP53 network, NFkappaB, TGFbeta, STAT signaling
Dr. Pandur Edina
13 Invasion and metastasis: genes and proteins involved in cell-to-cell, cell-matrix adhesion, in extracellular matrix remodeling
during tumor invasion; angiogenesis.
Dr. Pandur Edina
14 Invasion and metastasis: genes and proteins involved in cell-to-cell, cell-matrix adhesion, in extracellular matrix remodeling
during tumor invasion; angiogenesis.
Dr. Pandur Edina
15 The role of immune system in tumors: inflammation, infections, cancer vaccines, inhibition of the immune system
Pap Ramóna
16 The role of immune system in tumors: inflammation, infections, cancer vaccines, inhibition of the immune system
Pap Ramóna
17 Stem cells and cancer: Wnt signaling, Hh signaling, differentiation therapy
Dr. Pandur Edina
18 Stem cells and cancer: Wnt signaling, Hh signaling, differentiation therapy
Dr. Pandur Edina
19 Cancer prevention: nutrients, energy metabolism of tumors, hormones and gene interactions
Pap Ramóna
20 Cancer prevention: nutrients, energy metabolism of tumors, hormones and gene interactions
Pap Ramóna
21 Diagnosis of tumors: molecular diagnosis, molecular detection and classification
Jánosa Gergely
22 Diagnosis of tumors: molecular diagnosis, molecular detection and classification
Jánosa Gergely
23 Human cancers I: common properties, genetic aberrations, molecular alterations, histology and etiology of cancers
Dr. Tóth Dénes
24 Human cancers I: common properties, genetic aberrations, molecular alterations, histology and etiology of cancers
Dr. Tóth Dénes
25 Human cancers II: common properties, genetic aberrations, molecular alterations, histology and etiology of cancers
Dr. Tóth Dénes
26 Human cancers II: common properties, genetic aberrations, molecular alterations, histology and etiology of cancers
Dr. Tóth Dénes
27 Drugs in cancer therapy: molecular mechanisms of cancer chemotherapy, targeted drug therapy, immunotherapy, gene therapy
Dr. Poór Miklós
28 Drugs in cancer therapy: molecular mechanisms of cancer chemotherapy, targeted drug therapy, immunotherapy, gene therapy
Dr. Poór Miklós
Practices
Seminars
Exam topics/questions
Simple choice test based on the lectures.
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
75
OPF-SSG-T HISTOLOGY SEMINAR FOR PHARMACY STUDENTS
Course director: DR. GABRIELLA HORVÁTH-OPPER, associate professor
Department of Anatomy gabriella.horvath@aok.pte.hu
2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 3
Number of hours/semester: 0 lectures + 0 practices + 24 seminars = total of 24 hours
Course headcount limitations (min.-max.): 5 – 25 Prerequisites: OPO-AI2-T parallel
Topic
The aim of the subject is to complete the knowledge about structure of organ systems. Besides gross anatomy and basic histological
knowledge presented in mandatory anatomy courses, the ‘Histology seminars for pharmacy students’ offers better understanding of
histological background of physiological and oathophysiological processes and conditions.
Conditions for acceptance of the semester
The semester can not be accepted over 2 absences.
Mid-term exams
Multimedia test on last seminar.
Making up for missed classes
Not possible.
Reading material
- Obligatory literature
- Literature developed by the Department
http://an-server.pote.hu
- Notes
- Recommended literature
Lectures
Practices
Seminars
1 Histology of the skin I.
2 Histology of the skin II.
3 Histology of the gastrointestinal tract I.
4 Histology of the gastrointestinal tract II.
5 Histology of the gastrointestinal tract III.
6 Histology of the gastrointestinal tract IV.
7 Histology of the gastrointestinal tract V.
8 Histology of the gastrointestinal tract VI.
9 Histology of the kidney
10 Respiratory system.
11 Histology of the male genitalia I.
12 Histology of the male genitalia II.
13 Histology of the female genitalia I.
14 Histology of the female genitalia II.
15 Histology of the female genitalia III.
16 Histology of the female genitalia IV.
17 Endocrine organs I.
18 Endocrine organs II.
19 Histology of the peripheral nervous system i.
20 Histology of the peripheral nervous system II.
21 Eyebulb I.
22 Eyebulb II.
23 Test
24 Test
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
76
Exam topics/questions
http://an-server.pote.hu
Participants
Gaszner Tamás (YX6IQ5)
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
77
OPF-MGE-T MOLECULAR GERONTOLOGY
Course director: DR. KRISZTIÁN KVELL, associate professor
Department of Pharmaceutical Biotechnology kvell.krisztian@pte.hu
1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 3
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 5 – 200 Prerequisites: OPE-MS1-T completed
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
The curriculum covers physiological aspects of ageing and the molecular background of the ageing process, at cell, intracellular signaling
and nucleic acid level. It highlights the potential molecular intervention possibilities to slow down the ageing process and decrease
development of age related diseases.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Writing test
Making up for missed classes
None
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
www.medbiotech.com
- Recommended literature
Lectures
1 Basic Knowledge in Gerontology
Dr. Kvell Krisztián
2 Aging Theories
Dr. Kvell Krisztián
3 Mitochondrial Aging
Dr. Kvell Krisztián
4 Aging and Gene Expression
Dr. Kvell Krisztián
5 Genetic Background of Longevity
Dr. Kvell Krisztián
6 Alterations of the Genome due to Aging, Senescence and Cancer
Dr. Kvell Krisztián
7 Cellular Effects of Acute and Chronic Stress
Dr. Kvell Krisztián
8 Metabolism and Longevity I
Dr. Kvell Krisztián
9 Metabolism and Longevity II
Dr. Kvell Krisztián
10 Senescence-related Intracellular Pathologies
Dr. Kvell Krisztián
11 Senescence-related Intracellular Pathologies
Dr. Kvell Krisztián
12 Molecular Mechanisms of Interventions
Dr. Kvell Krisztián
13 Invited Lecturer I
Dr. Kvell Krisztián
14 Invited Lecturer II
Dr. Kvell Krisztián
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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Practices
Seminars
Exam topics/questions
MeetStreet
www.medbiotech.com
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
79
OPF-IPM-T INNOVATION AND PROJECT MANAGEMENT FROM A BUSINESS PERSPECTIVE (KÜLÖN
KURZUS!!!)
Course director: DR. RITA BOGNÁR, research associate professor
Department of Biochemistry and Medical Chemistry rita.bognar@aok.pte.hu
2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 3
Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours
Course headcount limitations (min.-max.): 1 – 24 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
The main objective of the innovation and project management course is to develop the business orientation skills of the students, while
deepening their knowledge in project management theory, methods and practice. Participants will have the capability how to develop
innovative projects for business.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Written test will be on the week 13.
Making up for missed classes
No way.
Reading material
- Obligatory literature
Not relevant.
- Literature developed by the Department
Lectures in pdf form will be available on Neptun Meet Street.
- Notes
Not relevant.
- Recommended literature
1. Joseph W. Weiss, Robert K. Wysocki (1992): 5-Phase Project Management: A Practical Planning & Implementation Guide,
Addison-Wesley
2. John Hauser, Gerard J. Tellis and Abbie Griffin: A Review and Agenda for „Marketing Science”, Marketing Science, Vol. 25, No.
6, 25th Anniversary Issue (Nov. - Dec., 2006), pp. 687-717
3. Barbara J. Gabrys, Jane A. Langdale (2012): How to succeed as a scientist, From Postdoc to Professor, Cambridge University
Press, New York, pp.45-57.
Lectures
1 Basics of project management (definition, objectives)
Dr. Bognár Rita
2 Global business overview
Dr. Bognár Rita
3 Project life cycle
Dr. Bognár Rita
4 Different type of business organization
Dr. Bognár Rita
5 Project initialisation (structure, work packages)
Dr. Bognár Rita
6 Leadership of a project
Dr. Bognár Rita
7 Human resource management (team building, teamwork)
Dr. Bognár Rita
8 Project planning 1. (time, resources)
Dr. Bognár Rita
9 Project planning 2. (cost, risk, communication)
Dr. Bognár Rita
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10 Project network
Dr. Bognár Rita
11 Project communication tools
Dr. Bognár Rita
12 Project protocol
Dr. Bognár Rita
13 Financial management 1. (Main budget categories)
Dr. Bognár Rita
14 Financial management 2.
Dr. Bognár Rita
15 Procurement management
Dr. Bognár Rita
16 Contracts
Dr. Bognár Rita
17 Risk management
Dr. Bognár Rita
18 Conflict management
Dr. Bognár Rita
19 Project controlling and monitoring
Dr. Bognár Rita
20 Project reporting
Dr. Bognár Rita
21 Project closing
Dr. Bognár Rita
22 Project maintenance
Dr. Bognár Rita
23 Innovation management 1.(Intellectual properties)
Dr. Bognár Rita
24 Innovation management 2. (Patent)
Dr. Bognár Rita
Practices
Seminars
Exam topics/questions
Neptun Meet Street
Participants
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OPF-HB1-T HOW TO ACHIEVE BETTER GRADE IN ORGANIC CHEMISTRY 1
Course director: DR. BALÁZS BOGNÁR, assistant professor
Department of Organic and Pharmacological Chemistry bazsikem@freemail.hu
1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 3
Number of hours/semester: 0 lectures + 0 practices + 10 seminars = total of 10 hours
Course headcount limitations (min.-max.): 2 – 20 Prerequisites: OPA-S1E-T parallel + OPA-GC1-T completed
Topic
The aim of the course is to help the students to understand the important reaction mechanisms, and find the connections between the
different topics.
1. Reaction mechanisms in organic chemistry
2. Projection structures, radical substitution
3. Electrophilic addition
4. Electrophilic aromatic substitution
5. Nucleophilic substitution 1, alkyl halides
6. 1. test
7. Nucleophilic substitution 2, organometallics, alcohols, phenols, ethers.
8. Aromatic nucleophilic substitutions
9. Stereochemistry
10. 2. test
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Nincs.
Making up for missed classes
Nincs
Reading material
- Obligatory literature
- Literature developed by the Department
The worksheets will be handed on the seminar.
- Notes
- Recommended literature
Estelle K. Meislich; Herbert Meislich; Jacob Sharefkin: Schaum’s Series 3000 Solved Problems In Organic Chemistry, McGraw-
Hill, Inc., New York, 1994
T. W. Graham Solomons: Organic Chemistry, 7th edition, Wiley and Sons, New York, 2000
John McMurry, Eric Simanek: Fundamentals of Organic Chemistry, 6th edition, Thomson Brooks/Cole, Belmont, 2007
Lectures
Practices
Seminars
1 Reaction mechanisms in organic chemistry.
2 Projection structures, radical substitutions and nomenclature of alkanes.
3 Reaction of alkenes and alkynes: electrophilic addition, oxidations.
4 Aromaticity, electrophilic aromatic substitution: mechanism, examples.
5 Nucleophilic substitutions of alkyl halides.
6 1. test (alkanes, alkenes, alkynes, aromatics, organohalides).
7 Nucleophilic substitution 2: synthesis and reactions organometallics, alcohols, phenols, ethers.
8 Aromatic nucleophilic substitutions of carbocycles.
9 Stereochemistry: classification of isomerism, absolut configuration.
10 2. test: alcohols, phenols, ethers, organometallics, isomerism.
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Exam topics/questions
There is no exam.
Participants
Dr. Bognár Balázs (U34DM4)
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OPF-EBK-T FOOD SAFETY AND CRISIS SITUATIONS
Course director: DR. TÍMEA VARJAS, assistant professor
Department of Public Health Medicine vtimi_68@yahoo.com
1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 3
Number of hours/semester: 12 lectures + 0 practices + 0 seminars = total of 12 hours
Course headcount limitations (min.-max.): 4 – 30 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
Although food legislation and legal background is strict in EU some food safety crises and emergencies occur we can hear just a few
word in the media about. This course „pulls the veil” of the background, causes and concealed information of food safety crises. Topics
are about the most interesting and important information of these situations.
Conditions for acceptance of the semester
Absences should not exceed 15% of lectures and practicals (2x45 min). Otherwise signature of grade book is denied.
Mid-term exams
Examination: written test
Making up for missed classes
based on individual consideration
Reading material
- Obligatory literature
- Literature developed by the Department
PPT-presentations (Neptun)
- Notes
- Recommended literature
Lectures
1 Introduction
Dr. Raposa László Bence
2 European and Hungarian food safety regulation
Dr. Raposa László Bence
3 Cases and concealed facts I. (Historical overview)
Dr. Raposa László Bence
4 Cases and concealed facts II.
Dr. Raposa László Bence
5 Crisis management and communication I.
Dr. Raposa László Bence
6 Crisis management and communication II.
Dr. Raposa László Bence
7 Food industry "tricks": Changes which the layman does not realize
Dr. Raposa László Bence
8 Food industry "tricks": Changes which the layman does not realize
Dr. Raposa László Bence
9 Actual food safety crisis
Dr. Raposa László Bence
10 Actual food safety crisis
Dr. Raposa László Bence
11 Summary
Dr. Raposa László Bence
12 Exam
Dr. Raposa László Bence
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Practices
Seminars
Exam topics/questions
Neptun
Participants
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OPF-H3B-T MEDICAL HUNGARIAN 3B - MEDICAL COMMUNICATION IN PRACTICE FOR STUDENTS OF
PHARMACY
Course director: GABRIELLA NAGY, language teacher
Department of Languages for Specific Purposes gabriella.nagy@aok.pte.hu
2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 3
Number of hours/semester: 0 lectures + 0 practices + 24 seminars = total of 24 hours
Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPE-H3A-T parallel + OPE-H2B-T completed
Topic
This course serves the skills development based on language and communicative functions acquired in course 3A.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Making up for missed classes
In the case of absences up to 25% of total class time, oral examination will have to be taken.
Reading material
- Obligatory literature
- Literature developed by the Department
Mária Győrffy: English for Doctors, Idióma Bt. Pécs, 2001 - can be purchased in the Department
- Notes
- Recommended literature
--
Lectures
Practices
Seminars
1 Family History, social history and previous diseases - Listening comprehension and speaking skills
2 Family History, social history and previous diseases - Listening comprehension and speaking skills
3 Complaint and Pain - Listening comprehension and speaking skills
4 Complaint and Pain - Listening comprehension and speaking skills
5 Headache, dizziness - Listening comprehension and speaking skills
6 Perspiration, nausea, vomiting - Listening comprehension and speaking skills
7 Vision, shortness of breath, cough - Listening comprehension and speaking skills
8 Stool, urine - Listening comprehension and speaking skills
9 Stool, urine - Listening comprehension and speaking skills
10 Heart complaints, appetite - Listening comprehension and speaking skills
11 Shivering, fever, oedema - Listening comprehension and speaking skills
12 Frequent diseases - Listening comprehension and speaking skills
13 Oesophagus, stomach, gallbladder - Listening comprehension and speaking skills
14 Bowel diseases, cardiovascular diseases - Listening comprehension and speaking skills
15 Forms of medications - Listening comprehension and speaking skills
16 Test 1
17 Types of medications - Listening comprehension and speaking skills
18 Types of medications - Listening comprehension and speaking skills
19 Instructions concerning the application of medications: oral medications - Listening comprehension and speaking skills
20 Instructions concerning the application of medications: oral medications - Listening comprehension and speaking skills
21 Instructions concerning the application of medications: drops - Listening comprehension and speaking skills
22 Instructions concerning the application of medications: creams and ointments - Listening comprehension and speaking skills
23 Prescriptions - Listening comprehension and speaking skills
24 Consolidation, Test 2.
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Exam topics/questions
http://aok.pte.hu/index.php?page=egyseg&egy_id=60&nyelv=eng&menu=okt_anyag
Participants
Dávidovics Anna (U5A10Z), Dr. Hegedűs Anita (TQQEMK), Dr. Hild Gabriella (HILSWV), Dr. Németh Tímea (X8VRGN), Dr. Rébék-
Nagy Gábor (DGOZG1), Dr. Warta Vilmos (SJYRAV), Eklicsné Dr. Lepenye Katalin (JMXXSC), Krommer Zoltán (MQ5HNA),
Kurdiné Molnár Eszter (VUCECC), Nagy Gabriella (CYMRX3), Ronczykné Berta Anikó (CJZOFU), Szalai-Szolcsányi Judit
(RBGAPH), Szántóné Dr. Csongor Alexandra (UDKY0J)
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OPF-H3A-T MEDICAL HUNGARIAN 3A - BASICS OF MEDICAL COMMUNICATION FOR STUDENTS OF
PHARMACY
Course director: GABRIELLA NAGY, language teacher
Department of Languages for Specific Purposes gabriella.nagy@aok.pte.hu
2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 3
Number of hours/semester: 0 lectures + 0 practices + 24 seminars = total of 24 hours
Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPE-H2A-T completed + OPF-H3B-T parallel
Topic
This course in devoted to the acquisition of language and communicative functions of the basic history taking process and the description
of medications.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Making up for missed classes
In the case of absences up to 25% of total class time, oral examination will have to be taken.
Reading material
- Obligatory literature
- Literature developed by the Department
Mária Győrffy: English for Doctors, Idióma Bt. Pécs, 2001 - can be purchased in the Department
- Notes
- Recommended literature
http://aok.pte.hu/index.php?page=egyseg&egy_id=60&menu=okt_anyag&nyelv=eng
Lectures
Practices
Seminars
1 Family History, social history and previous diseases
2 Family History, social history and previous diseases
3 Complaint and Pain
4 Complaint and Pain
5 Headache, dizziness
6 Perspiration, nausea, vomiting
7 Vision, shortness of breath, cough-Listening comprehension and speaking skills
8 Stool, urine
9 Stool, urine
10 Heart complaints, appetite
11 Shivering, fever, oedema
12 Frequent diseases
13 Oesophagus, stomach, gallbladder
14 Bowel diseases, cardiovascular diseases
15 Forms of medications
16 Test 1
17 Types of medications
18 Types of medications
19 Instructions concerning the application of medications: oral medications
20 Instructions concerning the application of medications: oral medications
21 Instructions concerning the application of medications: drops
22 Instructions concerning the application of medications: creams and ointments
23 Prescriptions
24 Test 2.
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Exam topics/questions
http://aok.pte.hu/index.php?page=egyseg&egy_id=60&nyelv=eng&menu=okt_anyag
Participants
Dávidovics Anna (U5A10Z), Dr. Hegedűs Anita (TQQEMK), Dr. Hild Gabriella (HILSWV), Dr. Németh Tímea (X8VRGN), Dr. Rébék-
Nagy Gábor (DGOZG1), Dr. Warta Vilmos (SJYRAV), Eklicsné Dr. Lepenye Katalin (JMXXSC), Krommer Zoltán (MQ5HNA),
Kurdiné Molnár Eszter (VUCECC), Nagy Gabriella (CYMRX3), Ronczykné Berta Anikó (CJZOFU), Szalai-Szolcsányi Judit
(RBGAPH), Szántóné Dr. Csongor Alexandra (UDKY0J)
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OPE-BKM-T BASIC METHODS OF SCIENTIFIC RESEARCH
Course director: DR. ÁGNES FARKAS, associate professor
Department of Pharmacognosy agnes.farkas@aok.pte.hu
2 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ spring semester ▪ recommended semester: 4
Number of hours/semester: 14 lectures + 0 practices + 14 seminars = total of 28 hours
Course headcount limitations (min.-max.): 3 – 15 Prerequisites: OPA-B2E-T completed + OPA-B2G-T completed
Topic
The course aims at introducing students to the basic steps of scientific research, guiding them through stages of becoming an independent
researcher. The course covers each step of the research process, from preparing a research plan to evaluating and reporting data. Students
will become familiar with various methods of literature search, data collection, data analysis, as well as the ethical questions of scientific
research. Students will be introduced to various types of scientific works, including rules and requirements of scientific communication.
A session will be dedicated to the special requirements of writing a thesis. Emphasis will be laid on practice: in the seminars students
should put into practice what they have learned in the lectures, based on their own research work.
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
Students will be required to perform some tasks related to their own research topic. The midsemester grade will be based on the successful
completion of the following tasks:
- literature search
- write a research plan
- prepare a questionnaire
- analyze data
- critically evaluate data, draw conclusions
- present results (oral and written format)
Making up for missed classes
Students can make up for absences by completing the tasks and home assignments of each class.
Reading material
- Obligatory literature
- Literature developed by the Department
Lecture materials are available at the website of the Department of Pharmacognosy.
- Notes
- Recommended literature
Turabian K. L. (2010): A Manual for Writers of Research Papers, Theses, and Dissertations. Chicago Style for Students &
Researchers. 8th edition. The University of Chicago Press. Chicago and London, pp. 448.
Lectures
1 Concept, process and strategies of scientific research. Organising research projects. Research plan.
Dr. Farkas Ágnes
2 Literature search
Dr. Farkas Ágnes
3 Methods of data collection. Questionnaires.
Dr. Farkas Ágnes
4 Designing experiments.
Dr. Farkas Ágnes
5 Data processing, data analysis.
Dr. Farkas Ágnes
6 Evaluation of data.
Dr. Farkas Ágnes
7 The role of informatics in scientific research.
Dr. Farkas Ágnes
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8 The role of informatics in scientific research.
Dr. Farkas Ágnes
9 Ethical questions of scientific research.
Dr. Farkas Ágnes
10 Animal studies. Clinical studies.
Dr. Farkas Ágnes
11 Scientific communication. Types of scientific works. Metrics of scientific achievement.
Dr. Farkas Ágnes
12 Rules and requirements in scientific communication.
Dr. Farkas Ágnes
13 Writing applications for scholarships and research grants.
Dr. Farkas Ágnes
14 Scientific co-operations. Scene and institutions of science in Hungary.
Dr. Farkas Ágnes
Practices
Seminars
1 Literature search in the field of the student’s own research I.
2 Literature search in the field of the student’s own research II.
3 Preparing a research plan based on the student’s own research objectives.
4 Preparing a questionnaire
5 Evaluation of data from the student’s research project I.
6 Evaluation of data from the student’s research project II.
7 Practice of scientific communication I.
8 Practice of scientific communication II.
9 Practice of scientific communication III.
10 Practice of scientific communication IV.
11 Practice of scientific communication V.
12 Practice of scientific communication VI.
13 Practice of writing an application for a scholarship I.
14 Practice of writing an application for a research project II.
Exam topics/questions
1. Research plan.
2. Methods of data collection.
3. Questionnaires.
4. Methods of literature search.
5. Methods of data analysis.
6. Critical evaluation of data.
7. Ethical questions of scientific research.
8. Animal studies. Clinical studies.
9. Scientific writing: types, rules and requirements.
10. References, bibliography.
11. Scene and institutions of science in Hungary.
Participants
Dr. Farkas Ágnes (DKQUBQ)
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OPE-GMO-T MODELLING THE STRUCTURE AND INTERACTIONS OF BIOACTIVE MOLECULES
Course director: DR. SÁNDOR KUNSÁGI-MÁTÉ, associate professor
Department of Pharmaceutical Chemistry kunsagi-mate.sandor@gytk.pte.hu
2 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ both semesters ▪ recommended semester: 4
Number of hours/semester: 17 lectures + 11 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 4 – 20 Prerequisites: none
Topic
In this course the basic examination methods of theoretical chemistry will be discussed by the practical point of view in the frame of
following subtopics: Methods of molecular modelling. Description of the forcefield, semiempirical, ab initio and density functional
methods, advantages and disadvantages. Discovering the balance between the model ant the calculation methods. The algorithm of the
choice of appropriate model and calculation method. Short description of the basic rules and mathematical background of theoretical
chemistry. calculation of the electronic structure of atoms and molecules. Calculation the equilibrium conformations of molecules, the
role of the entropy in the interactions of bioactive molecules and its calculation. Description of the correlation between the reactivity and
the temperature. Examples at molecular level. Considering the molecular environment: explicit and implicit methods. Interesting
examples and applications in pharmacy.
Conditions for acceptance of the semester
There is no possibility to make up for a missed lecture
Mid-term exams
Two tests, each above 60 % is required for acceptance
Making up for missed classes
Upto 15% is allowed, electronical material is available
Reading material
- Obligatory literature
P.W. Atkins: Physical Chemistry
- Literature developed by the Department
Slides and notes. Scientific publications presented are also offered.
- Notes
Slides and Summaries of lectures are available electronically
- Recommended literature
Jensen_F.-Introduction_to_Computational_Chemistry_(2007)
Scientific papers, list will be given during the lectures
Lectures
1 1 lecture Experimental results raise the necessity of quantum-chemical description of the structure of materials. Quantitization
and related quantities (energy, momentum, spin). Simple mathematical descriptions.
Dr. Kunsági-Máté Sándor
2 1 lecture Experimental results raise the necessity of quantum-chemical description of the structure of materials. Quantitization
and related quantities (energy, momentum, spin). Simple mathematical descriptions.
Dr. Kunsági-Máté Sándor
3 2 lecture Axiomatic description of the quantum theory. Atomic unit system. Overview on the exact and approximative solutions
of the time - independent Schrödinger equation.
Dr. Kunsági-Máté Sándor
4 2 lecture Axiomatic description of the quantum theory. Atomic unit system. Overview on the exact and approximative solutions
of the time - independent Schrödinger equation.
Dr. Kunsági-Máté Sándor
5 3 lecture Approximative solutions: the molecular mechanics methods.
Dr. Kunsági-Máté Sándor
6 3 lecture Approximative solutions: the molecular mechanics methods.
Dr. Kunsági-Máté Sándor
7 4 lecture Semi - empirical methods, advantages and disadvantages.
Dr. Kunsági-Máté Sándor
9 5 lecture Conformation analysis, energy minimization algorithms.
Dr. Kunsági-Máté Sándor
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11 6 lecture Electronic structure of molecules. The chemical bonds, tipes of bonds. The structure of molecules, stereochemistry.
Dr. Kunsági-Máté Sándor
13 7 lecture Modelling in comparison with the experiments, calculation of the enthalpy, entropy and their appropriate experimental
values.
Dr. Kunsági-Máté Sándor
15 8 lecture Molecular symmetry, point groups and the symmetry of molecular vibrations.
Dr. Kunsági-Máté Sándor
17 9 lecture Interactions of the primycin, ergosterol and oleic acid as plasma membrane unit.
Dr. Kunsági-Máté Sándor
19 10 lecture Modelling the interactions of bioactive molecules with molecular containers in accordance with molecular packing of
drugs.
Dr. Kunsági-Máté Sándor
21 11 lecture Quantum - chemical background of the rules in atomic and molecular spectroscopy. Rules of Raman and Infrared
transitions and their relationship with the molecular symmetry.
Dr. Kunsági-Máté Sándor
23 12 lecture Effective calculation methods to consider the molecular environment: Onsager-model, Polarizable Continuum Model
Dr. Kunsági-Máté Sándor
25 13 lecture Examples: simple chemical reactions, calculation of the stability weak molecular complexes, conformation analysis.
Dr. Kunsági-Máté Sándor
27 14 lecture Examples: modelling the systems possessing high symmetry and infinite volume. Crystals and polymers.
Dr. Kunsági-Máté Sándor
Practices
4 4 practice : Geometry optimization and conformation analysis. Energy minimization algorythm mostly used in geometry
optimization practice.
Dr. Kunsági-Máté Sándor
5 5 practice: Calculation of the static potential energy surfaces of chemical reactions. Methods to determine the transition states
associated to the chemical reactions. Activation energy and activation free enthalpy.
Dr. Kunsági-Máté Sándor
6 6 practice Molecular dynamics methods, Monte-Carlo method and the Langevin model. The implicite consideration of the
molecular environment.
Dr. Kunsági-Máté Sándor
7 7 practice Modelling the elementary chemical reactions. Calculation of molecular dynamics. Determination of the rection rate
using direct trajectory method.
Dr. Kunsági-Máté Sándor
8 8 practice Methods for consideration of the solvents: the Onsager-model, and the Polarizable Continuum Model, PCM. Explicit
consideration of the solvent molecules. The TIP3P model.
Dr. Kunsági-Máté Sándor
9 9 practice Calculation of molecular parameters have significant importance in the practice. The QSAR and the molecular
similarity - analysis.
Dr. Kunsági-Máté Sándor
10 10 practice Examples: conformation analysis, bong length, bond angle and dihedral angles. The bipyridile and thionine molecules.
Calixarenes and stereoisomers. Importance of hydrogen bonds in the stability of molecular geometries.
Dr. Kunsági-Máté Sándor
11 11 practice Examples: interactions of molecules. Calculation of the host - guest interactions, calculations of interactions of
calixarenes with neutral molecules based on pi-pi interactions.
Dr. Kunsági-Máté Sándor
12 12 practice Examples : elementary dissociation reactions: dissociation of asymmetric olefines. Effect of melecular environment
on the reaction rate.
Dr. Kunsági-Máté Sándor
13 13 practice Examples: Interaction of Primycin and oleic acid. Calculation of the interaction energy in system possessing large
numbers of electrons.
Dr. Kunsági-Máté Sándor
14 14 practice E+xamples: dynamic processes: modelling the crystal growth.
Dr. Kunsági-Máté Sándor
Seminars
Exam topics/questions
Methods of molecular modelling. Description of the forcefield, semiempirical, ab initio and density functional methods, avantages and
disadvantages. The balance between the model ant the calculation methods. The algorithm of the choice of appropriate model and
calculation method.Short description of the basic rules and mathematical background of theoretical chemistry. calculation of the
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electronic structure of atoms and molecules. Calculation the equilibrium conformations of molecules, the role of the entropy in the
interactions of bioactive molecules and its calculation. Description of the correlation between the reactivity and the temperature.
Examples at moecular level. Considering the molecular environment: explicit and implicit methods. Interesting examples and
applications in pharmacy.
Participants
Dr. Kunsági-Máté Sándor (UYZM2Q)
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OPE-SME-T SPECTROMETRIC IDENTIFICATION OF ORGANIC COMPOUNDS
Course director: DR. CECILIA PÁPAY- SÁR, associate professor
Department of Organic and Pharmacological Chemistry cecilia.sar@aok.pte.hu
2 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ spring semester ▪ recommended semester: 4
Number of hours/semester: 0 lectures + 0 practices + 24 seminars = total of 24 hours
Course headcount limitations (min.-max.): 2 – 10 Prerequisites: OPA-S1E-T completed
Topic
The aim of this course is to introduce the students how to identify organic compounds from the complementary information afforded by
three types of spectra: infrared, mass and NMR.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
The student who has been absent from more than 25 % of the classes cannot be granted to entry of exam.
Making up for missed classes
Students can personally consult with the lecturer.
Reading material
- Obligatory literature
Silverstein, R.M., Webster, F.X., Kiemle, D.: Spectrometric Identification of Organic Compounds, John Wiley and Sons, 2005.
- Literature developed by the Department
- Notes
- Recommended literature
Lectures
Practices
Seminars
1 Infrared Spectroscopy: Introduction, theory, instrumentation, interpretation of spectra
2 Infrared Spectroscopy: Introduction, theory, instrumentation, interpretation of spectra
3 Infrared Spectroscopy: Characteristic group absorptions of organic molecules
4 Infrared Spectroscopy: Characteristic group absorptions of organic molecules
5 Infrared Spectroscopy: Solving problems
6 Infrared Spectroscopy: Solving problems
7 Proton Magnetic Resonance Spectrometry (1H NMR): Introduction, theory, instrumentation
8 Proton Magnetic Resonance Spectrometry (1H NMR): Introduction, theory, instrumentation
9 1H NMR: Chemical shift, simple spin coupling
10 1H NMR: Chemical shift, simple spin coupling
11 1H NMR: Protons on heteroatoms, chemical shift equivalence and magnetic equivalence, effects of a chiral center
12 1H NMR: Protons on heteroatoms, chemical shift equivalence and magnetic equivalence, effects of a chiral center
13 13 C NMR Spectroscopy: Interpretation of 13 C spectra. The principles of MRI
14 1H NMR and 13 C NMR: Solving problems
15 Mass Spectrometry: Mass spectrometer parts, ionization processes
16 Mass Spectrometry: Mass spectrometer parts, ionization processes
17 Mass Spectrometry: Appearance of the mass spectrum, mass spectra of classes of organic compounds
18 Mass Spectrometry: Appearance of the mass spectrum, mass spectra of classes of organic compounds
19 Mass Spectrometry: Interpretation of the mass spectrum through examples
20 Mass Spectrometry: Interpretation of the mass spectrum through examples
21 Summary of spectroscopic methods: identification of organic molecules from IR, NMR and mass spectra
22 Summary of spectroscopic methods: identification of organic molecules from IR, NMR and mass spectra
23 Summary of spectroscopic methods: identification of organic molecules from IR, NMR and mass spectra
24 Evaluation, written test
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Exam topics/questions
Infrared Spectroscopy: theory, instrumentation, interpretation of spectra, chacteristic group absorptions of organic molecules.
Proton Magnetic Resonance Spectrometry (1H NMR): theory, instrumentation, chemical shift, simple spin coupling, protons on
heteroatoms, chemical shift equivalence and magnetic equivalence, effects of a chiral center.
Mass Spectrometry: mass spectrometer parts, ionization processes, appearance of the mass spectrum, mass spectra of classes of organic
compounds.
Identification of simple organic molecules from IR, NMR and mass spectra.
Participants
Dr. Kálai Tamás (BDF5M9), Dr. Pápayné Dr. Sár Cecilia (BTYFJX)
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OPE-TIZ-T CENTRAL REGULATION OF FEEDING AND METABOLISM. NEW APPROACHES
Course director: DR. ZOLTÁN KARÁDI, professor
Institute of Physiology zoltan.karadi@aok.pte.hu
1 credit ▪ midsemester grade ▪ Elective subject for the Medical-biological module ▪ spring semester ▪ recommended semester: 4
Number of hours/semester: 12 lectures + 0 practices + 0 seminars = total of 12 hours
Course headcount limitations (min.-max.): 2 – 25
Prerequisites: OPO-AI2-T completed + OPO-H1E-T completed + OPO-G1B-T parallel
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
The high incidence and costs of eating and metabolic disorders make it indispensable to experimentally test new theoretical
considerations, and to employ their conclusive results in basically new clinical protocols. Students at early stage of their studies are, thus,
encouraged to familiarize with new theoretical aspects and experimental findings.
Neural and humoral mechanisms in the central feeding control and metabolic regulation. Body weight control in health and disease.
Peripheral and central taste information processing; gustation in the central regulation of food and fluid intake. Obesity, diabetes mellitus
and the metabolic syndrome: New interpretations.
Conditions for acceptance of the semester
According to general regulations
Mid-term exams
Individual oral mid-semester test.
Making up for missed classes
Individually discussed
Reading material
- Obligatory literature
Guyton & Hall: Textbook of Medical Physiology, Saunders
- Literature developed by the Department
- Notes
- Recommended literature
Williams and Pickup: Handbook of Diabetes, Blackwell
Doty: Handbook of Olfaction and Gustation, Marcel Dekker
Lectures
1 Physiological significance of food and fluid intake, and metabolism. Homeostasis, motivation.
Dr. Karádi Zoltán
2 Neuronal and humoral factors in the central regulation of homeostatic functions: brain centers, neurotransmitter pathways,
neuropeptides. I
Dr. Karádi Zoltán
3 Neuronal and humoral factors in the central regulation of homeostatic functions: brain centers, neurotransmitter pathways,
neuropeptides. II
Dr. Karádi Zoltán
4 Neuronal and humoral factors in the central regulation of homeostatic functions: brain centers, neurotransmitter pathways,
neuropeptides. III
Dr. Karádi Zoltán
5 Exogenous chemosensory modalities. Physiologic roles of gustation.
Dr. Karádi Zoltán
6 Central taste pathways, „labeled lines”, neurons.
Dr. Karádi Zoltán
7 Taste preference, taste aversion, palatability, flavour.
Dr. Karádi Zoltán
8 The glucose-monitoring (GM) neural network. I
Dr. Karádi Zoltán
9 The glucose-monitoring (GM) neural network. II
Dr. Karádi Zoltán
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10 Eating and metabolic disorders: obesity, anorexia nervosa, diabetes mellitus, metabolic syndrome. I
Dr. Karádi Zoltán
11 Eating and metabolic disorders: obesity, anorexia nervosa, diabetes mellitus, metabolic syndrome. II
Dr. Karádi Zoltán
12 Feeding and metabolic disorders: disturbance of the GM system?
Dr. Karádi Zoltán
Practices
Seminars
Exam topics/questions
1. Feeding (hunger) and satiety centers; feeding (hunger) and satiety neural pathways.
2. Orexigenic and anorexigenic neuromodulator factors (list up at least 3 of each).
3. The two major neuron types of the hypothalamic arcuate nucleus (with respect to feeding); their modulation by insulin, leptin, and
ghrelin.
4. Key structures of the central glucose-monitoring neuronal network (list up at least 4 of them).
5. Consequences of selective destruction of central GM neurons (name of the toxic agent, and its effects).
Participants
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OPF-QBI-T QUANTUM BIOLOGY: QUANTUM PHENOMENA IN BIOLOGICAL PROCESSES
Course director: DR. KRISZTIÁN KVELL, associate professor
Department of Pharmaceutical Biotechnology kvell.krisztian@pte.hu
2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 4
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 3 – 50 Prerequisites: OPO-G2B-T completed
Topic
Course description:
Based on common scientific approach quantum phenomena are not relevant in biological processes. The living cell has relatively large
dimensions, is filled with hydrated vibrating macromolecules, and follows the rules thermodynamics rather than quantum mechanics.
Yet, besides attractive theories, experimental data also accumulate suggesting that living cells readily exploit quantum phenomena.
Several biological processes require quantum biology approach for full understanding. These include photosynthesis, various enzyme
activities, DNA mutation accumulation, avian magnetoreception, mammalian olfaction etc. During the course students get familiar with
the quantum biology explanation of these biological processes.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
There will be several occasions for the students to rewrite midterm tests.
Making up for missed classes
Students will get e-learning material to cope to follow the course at home.
Reading material
- Obligatory literature
Life on the edge: The coming of age of quantum biology, Johnjoe McFadden, Jim Al-Khalili, Broadway Books (2016) 368 pages,
ISBN-13: 978-0307986825
- Literature developed by the Department
Topics:
- Quantum phenomena and basics terms
- Thermodynamics vs quantum mechanics
- Structural characteristics of biological macromolecules
- Quantum biology approach of the living cell
- Quantum biology approach of cell death
- Quantum biology approach of molecular energy transport
- Quantum biology approach of genetic mutation accumulation
- Quantum biology approach of photosynthesis
- Quantum biology approach of enzyme activity
- Quantum biology approach of avian magnetoreception
- Quantum biology approach of mammalian olfaction
- Quantum biology approach of the conscious mind
- Basic principles of quantum computers and quantum biology analogies
- Written exam
- Notes
Life on the edge: The coming of age of quantum biology, Johnjoe McFadden, Jim Al-Khalili, Broadway Books (2016) 368 pages,
ISBN-13: 978-0307986825
- Recommended literature
Life on the edge: The coming of age of quantum biology, Johnjoe McFadden, Jim Al-Khalili, Broadway Books (2016) 368 pages,
ISBN-13: 978-0307986825
Lectures
1 Quantum phenomena and basics terms I.
Dr. Lukács András Szilárd
2 Quantum phenomena and basics terms II.
Dr. Lukács András Szilárd
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3 Thermodynamics vs quantum mechanics I.
Dr. Lukács András Szilárd
4 Thermodynamics vs quantum mechanics II.
Dr. Lukács András Szilárd
5 Structural characteristics of biological macromolecules I.
Dr. Kvell Krisztián
6 Structural characteristics of biological macromolecules II.
Dr. Kvell Krisztián
7 Quantum biology approach of the living cell I.
Dr. Ábrahám István Miklós
8 Quantum biology approach of the living cell II.
Dr. Ábrahám István Miklós
9 Quantum biology approach of cell death I.
Dr. Ábrahám István Miklós
10 Quantum biology approach of cell death II.
Dr. Ábrahám István Miklós
11 Quantum biology approach of molecular energy transport I.
Dr. Pál Szilárd
12 Quantum biology approach of molecular energy transport II.
Dr. Pál Szilárd
13 Quantum biology approach of genetic mutation accumulation I.
Dr. Kvell Krisztián
14 Quantum biology approach of genetic mutation accumulation II.
Dr. Kvell Krisztián
15 Written exam
Dr. Kvell Krisztián
16 Quantum biology approach of photosynthesis I.
Dr. Hoffmann Gyula
17 Quantum biology approach of photosynthesis II.
Dr. Hoffmann Gyula
18 Quantum biology approach of enzyme activity I.
Dr. Pál Szilárd
19 Quantum biology approach of enzyme activity II.
Dr. Pál Szilárd
20 Quantum biology approach of avian magnetoreception I.
Dr. Hoffmann Gyula
21 Quantum biology approach of avian magnetoreception II.
Dr. Hoffmann Gyula
22 Quantum biology approach of mammalian olfaction I.
Dr. Hoffmann Gyula
23 Quantum biology approach of mammalian olfaction II.
Dr. Hoffmann Gyula
24 Quantum biology approach of the conscious mind I.
Dr. Sik Attila Gábor
25 Quantum biology approach of the conscious mind II.
Dr. Sik Attila Gábor
26 Basic principles of quantum computers and quantum biology analogies I.
Dr. Kvell Krisztián
27 Basic principles of quantum computers and quantum biology analogies II.
Dr. Kvell Krisztián
28 Written exam
Dr. Kvell Krisztián
Practices
Seminars
Exam topics/questions
https://www.dropbox.com/home/munka/Kvantumbiológia?preview=LifeOnTheEdge2014.pdf
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Participants
Dr. Ábrahám István Miklós (HQI9FH), Dr. Hoffmann Gyula (JB4TQB), Dr. Kvell Krisztián (Y0GLOV), Dr. Lukács András Szilárd
(LZ2I4Q), Dr. Miskei György Zsolt (PTAG3C), Dr. Pál Szilárd (FYF5E9), Dr. Sik Attila Gábor (A12OXW)
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OPF-GMI-T GYÓGYSZERÉSZEK A MINDENNAPOKBAN - ANGOL VÁLTOZAT
Course director: DR. ÁGNES FARKAS, associate professor
Department of Pharmacognosy agnes.farkas@aok.pte.hu
1 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 4
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 3 – 30 Prerequisites: none
Topic
This course intends to provide insight into various career opportunities for graduates with a degree in pharmacy. Invited speakers working
in various fields of the pharmaceutical profession talk about characteristic features of their job, including daily routine, challenging
situations and peculiarities they have come accross. Speakers represent pharmacists working in community pharmacies, clinical
pharmacies, in the pharmaceutical industry, as well as at health authorities and at universities or research institutes.
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
Active participation is expected from students. They should be prepared to ask questions from each speaker and they are requested to
take notes on each occasion. These notes should be handed in to the course instructor at the end of each class.
The final grade is based on students’ activity in class and the written notes they have taken on each occassion.
Making up for missed classes
There is no opportunity to make up for absences, since different speakers are invited to each class.
Reading material
- Obligatory literature
None
- Literature developed by the Department
- Notes
- Recommended literature
Lectures
1 Invited speaker. Pharmacist at a community pharmacy.
Dr. Farkas Ágnes
2 Invited speaker. Pharmacist at a community pharmacy.
Dr. Farkas Ágnes
3 Invited speaker. Pharmacist at a clinical pharmacy.
Dr. Lankó Erzsébet
4 Invited speaker. Pharmacist at a clinical pharmacy.
Dr. Lankó Erzsébet
5 Invited speaker. Pharmacist working in the pharmaceutical industry.
Dr. Farkas Ágnes
6 Invited speaker. Pharmacist working in the pharmaceutical industry.
Dr. Farkas Ágnes
7 Invited speaker. Pharmacist working at a university.
Dr. Poór Miklós
8 Invited speaker. Pharmacist working at a university.
Dr. Poór Miklós
9 Invited speaker. Pharmacist working in a research institute.
Dr. Farkas Ágnes
10 Invited speaker. Pharmacist working in a research institute.
Dr. Farkas Ágnes
11 Invited speaker. Pharmacist working at the health authorities.
Dr. Kuzma Mónika
12 Invited speaker. Pharmacist working at the health authorities.
Dr. Kuzma Mónika
13 Invited speaker. Daily routine of a specialty pharmacist.
Dr. Szabóné Dr. Schirm Szilvia
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14 Invited speaker. Daily routine of a specialty pharmacist.
Dr. Szabóné Dr. Schirm Szilvia
Practices
Seminars
Exam topics/questions
No exam questions.
Participants
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OPF-H4A-T MEDICAL HUNGARIAN 4A - BASICS OF MEDICAL COMMUNICATION FOR STUDENTS OF
PHARMACY
Course director: GABRIELLA NAGY, language teacher
Department of Languages for Specific Purposes gabriella.nagy@aok.pte.hu
2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 4
Number of hours/semester: 0 lectures + 0 practices + 24 seminars = total of 24 hours
Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPF-H3A-T completed + OPF-H4B-T parallel
Topic
This course provides language and communicative functions in the areas of medications, the application of medications and prescribing
medications and is also meant to give opportunities for putting skills and knowledge into practice in preparation for the final exam.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
--
Making up for missed classes
In the case of absences up to 25% of total class time, oral examination will have to be taken.
Reading material
- Obligatory literature
- Literature developed by the Department
Hand-outs
- Notes
- Recommended literature
Lectures
Practices
Seminars
1 Types and forms of medications - Review
2 Application of medications - Review
3 Instructions concerning the use of medications: pain relievers
4 Instructions concerning the use of medications: pain relievers
5 Instructions concerning the use of medications: antipyretics
6 Instructions concerning the use of medications: cough medications
7 Instructions concerning the use of medications: antidiabetics
8 Instructions concerning the use of medications: spasmolytics
9 Instructions concerning the use of medications: sleeping pills
10 Instructions concerning the use of medications: steroids
11 Instructions concerning the use of medications: antibiotics
12 Instructions concerning the use of medications: antiinflammatory medications
13 Instructions concerning the use of medications: emetics and antiemetics
14 Instructions concerning the use of medications: eye, ear and nasal drops
15 Instructions concerning the use of medications: medications applied to the skin
16 Test 1
17 Instructions concerning the use of medications: suppository
18 First aid instruments
19 Preparation for the Final Exam in Medical Hungarian
20 Preparation for the Final Exam in Medical Hungarian
21 Preparation for the Final Exam in Medical Hungarian
22 Preparation for the Final Exam in Medical Hungarian
23 Preparation for the Final Exam in Medical Hungarian
24 Test 2. Course evaluation
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Exam topics/questions
http://aok.pte.hu/index.php?page=egyseg&egy_id=60&nyelv=eng&menu=okt_anyag
Participants
Dávidovics Anna (U5A10Z), Dr. Hegedűs Anita (TQQEMK), Dr. Hild Gabriella (HILSWV), Dr. Németh Tímea (X8VRGN), Dr. Rébék-
Nagy Gábor (DGOZG1), Dr. Warta Vilmos (SJYRAV), Eklicsné Dr. Lepenye Katalin (JMXXSC), Krommer Zoltán (MQ5HNA),
Kurdiné Molnár Eszter (VUCECC), Nagy Gabriella (CYMRX3), Ronczykné Berta Anikó (CJZOFU), Szalai-Szolcsányi Judit
(RBGAPH), Szántóné Dr. Csongor Alexandra (UDKY0J)
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OPF-H4B-T MEDICAL HUNGARIAN 4B - MEDICAL COMMUNICATION IN PRACTICE FOR STUDENTS OF
PHARMACY
Course director: GABRIELLA NAGY, language teacher
Department of Languages for Specific Purposes gabriella.nagy@aok.pte.hu
2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 4
Number of hours/semester: 0 lectures + 0 practices + 24 seminars = total of 24 hours
Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPF-H3B-T completed + OPF-H4A-T parallel +
Topic
This course provides language and communicative functions in the areas of medications, the application of medications and prescribing
medications and is also meant to give opportunities for putting skills and knowledge into practice in preparation for the final exam.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Making up for missed classes
In the case of absences up to 25% of total class time, oral examination will have to be taken.
Reading material
- Obligatory literature
- Literature developed by the Department
Hand-outs
- Notes
- Recommended literature
Lectures
Practices
Seminars
1 Types and forms of medications - Review
2 Application of medications - Review
3 Instructions concerning the use of medications: pain relievers - Pharmacist-patient dialogues
4 Instructions concerning the use of medications: pain relievers- Pharmacist-patient dialogues
5 Instructions concerning the use of medications: antipyretics- Pharmacist-patient dialogues
6 Instructions concerning the use of medications: cough medications- Pharmacist-patient dialogues
7 Instructions concerning the use of medications: antidiabetics- Pharmacist-patient dialogues
8 Instructions concerning the use of medications: spasmolytics- Pharmacist-patient dialogues
9 Instructions concerning the use of medications: sleeping pills- Pharmacist-patient dialogues
10 Instructions concerning the use of medications: steroids- Pharmacist-patient dialogues
11 Instructions concerning the use of medications: antibiotics- Pharmacist-patient dialogues
12 Instructions concerning the use of medications: antiinflammatory medications- Pharmacist-patient dialogues
13 Instructions concerning the use of medications: emetics and antiemetics- Pharmacist-patient dialogues
14 Instructions concerning the use of medications: eye, ear and nasal drops- Pharmacist-patient dialogues
15 Instructions concerning the use of medications: medications applied to the skin- Pharmacist-patient dialogues
16 Test 1
17 Instructions concerning the use of medications: suppository- Pharmacist-patient dialogues
18 First aid instruments
19 Preparation for the Final Exam in Medical Hungarian
20 Preparation for the Final Exam in Medical Hungarian
21 Preparation for the Final Exam in Medical Hungarian
22 Preparation for the Final Exam in Medical Hungarian
23 Preparation for the Final Exam in Medical Hungarian
24 Test 2. Course evaluation
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Exam topics/questions
http://aok.pte.hu/index.php?page=egyseg&egy_id=60&nyelv=eng&menu=okt_anyag
Participants
Dávidovics Anna (U5A10Z), Dr. Hegedűs Anita (TQQEMK), Dr. Hild Gabriella (HILSWV), Dr. Németh Tímea (X8VRGN), Dr. Rébék-
Nagy Gábor (DGOZG1), Dr. Warta Vilmos (SJYRAV), Eklicsné Dr. Lepenye Katalin (JMXXSC), Krommer Zoltán (MQ5HNA),
Kurdiné Molnár Eszter (VUCECC), Nagy Gabriella (CYMRX3), Ronczykné Berta Anikó (CJZOFU), Szalai-Szolcsányi Judit
(RBGAPH), Szántóné Dr. Csongor Alexandra (UDKY0J)
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OPF-HB2-T HOW TO ACHIEVE BETTER GRADE IN ORGANIC CHEMISTRY 2
Course director: DR. BALÁZS BOGNÁR, assistant professor
Department of Organic and Pharmacological Chemistry bazsikem@freemail.hu
1 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 4
Number of hours/semester: 0 lectures + 0 practices + 10 seminars = total of 10 hours
Course headcount limitations (min.-max.): 2 – 20 Prerequisites: OPA-S2E-T parallel + OPA-S1E-T completed
Topic
The aim of the course is to help the students to understand the important reaction mechanisms, and find the connections between the
different topics.
1. Revision of addition and substitution reactions
2. Basicity and reactivity of amines
3-4. Reactions of carbonyl compounds, nucleophilic additions, condensations
5. Isomerisations in carbohydrates
6. 1. test
7. Acidity of carboxylic acids
8. Reactions of carboxylic acids and their derivatives
9. Aromatic substitutions of heteroaromatics
10. 2. test
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Nincs.
Making up for missed classes
Nincs.
Reading material
- Obligatory literature
- Literature developed by the Department
The worksheets will be granted on the seminar.
- Notes
- Recommended literature
Estelle K. Meislich; Herbert Meislich; Jacob Sharefkin: Schaum’s Series 3000 Solved Problems In Organic Chemistry, McGraw-
Hill, Inc., New York, 1994.
T. W. Graham Solomons: Organic Chemistry, 7th edition, Wiley and Sons, New York, 2000.
John McMurry, Eric Simanek: Fundamentals of Organic Chemistry, 6th edition, Thomson Brooks/Cole, Belmont, 2007.
Lectures
Practices
Seminars
1 Revision of the most important reaction mechanisms from the 1. semester: addition and substitution reactions.
2 Basicity, synthesis and reactions of amines.
3 Reactions of carbonyl compounds, nucleophilic additions, condensations with S,- N,- O-nucleophiles.
4 Reactions of carbonyl compounds, nucleophilic additions, condensations with C-nucleophiles.
5 Isomerisations and reactions in carbohydrates.
6 1. test: amines, aldehydes, ketons, carbohydrates.
7 Acidity and reactions of carboxylic acids.
8 Reactions of carboxylic acids and their derivatives (amides, esters anhydrides).
9 Aromatic nucleophilic and electrophilic substitutions of heteroaromatics.
10 2. test: carboxylic acids and its derivatives, heterocycles.
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Exam topics/questions
There is no exam.
Participants
Dr. Bognár Balázs (U34DM4)
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OPF-VAN-T IRON METABOLISM: FROM MOLECULAR MECHANISMS TO CLINICAL CONSEQUENCES
Course director: DR. EDINA PANDUR, assistant professor
Department of Pharmaceutical Biology edina.pandur@aok.pte.hu
2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 4
Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours
Course headcount limitations (min.-max.): 4 – 30 Prerequisites: OPO-G2B-T completed
Topic
During the course we will discuss the role of iron in the metabolism. We will deal with the iron demand of microorganisms and with the
role of iron in the protective mechanisms against bacterial infections. We will discuss the possibilities of iron uptake and intracellular
iron utilistaion, especially heme synthesis, and the syntesis of iron-sulfur clusters. The iron storage and iron mobilization from stores will
be discussed in details. We reveal the functions of iron regulatory factors, their crosstalks, and the functions of the iron-containing
proteins. Based on the brand new literature we discuss the the positive and negative regulators of the master iron regulator hepcidin.
During the course we will deal with the different types of iron disorders and diseases (anemias, thalassemias, secondary iron overload,
hemochromatosis) their genetic background, and therapeutic approaches. Based on the most actual findings the role of iron in the
developpment of neurodegenerative diseases (Parkinson’s disease, Alzheimer’s disease and Huntington’s disease) will be also discussed.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
One midterm exam, one possibility for retake.
Making up for missed classes
Personal consultation
Reading material
- Obligatory literature
- Literature developed by the Department
The lectures will be uploaded to the Neptun Meet street.
- Notes
- Recommended literature
Robert Crichton: Iron metabolism 4th Edition
Sarika Arora: Iron metabolism
Lectures
1 Solution chemistry of iron
Jánosa Gergely
2 Interactions between iron other metal ion
Jánosa Gergely
3 The Importance of Iron for Biological Systems: haemoproteins, iron-sulfur proteins, other iron containing proteins
Pandur Edina Dr.
4 Microbial Iron Transport and Metabolism
Poór Viktor Soma Dr.
5 Iron Acquisition by pathogens
Poór Viktor Soma Dr.
6 Iron metabolism of yeasts
Pap Ramóna
7 Iron uptake by plants
Pandur Edina Dr.
8 Iron homeostasis in plants
Pandur Edina Dr.
9 Cellular Iron Uptake and Export in Mammals: iron transporters
Pandur Edina Dr.
10 Mammalian intestinal iron absorption
Pandur Edina Dr.
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11 Intracellular Iron Storage
Pandur Edina Dr.
12 Intracellular Iron Metabolism and Cellular Iron Homeostasis I: Labile iron pool, mitochondrial iron uptake and metabolism haem
biosynthesis
Pap Ramóna
13 Intracellular Iron Metabolism and Cellular Iron Homeostasis II: synthesis of iron-sulfur clusters, functions of iron responsive
elements and iron regulatory proteins
Pap Ramóna
14 Regulation of Systemic Iron Metabolism: positive regulators of hepcidin
Pandur Edina Dr.
15 Regulation of Systemic Iron Metabolism: negative regulators of hepcidin
Pandur Edina Dr.
16 Pathophysiology of Iron metabolism: anemias (IDA, IRIDA, ACD)
Jánosa Gergely
17 Pathophysiology of Iron metabolism: thalassemias and secondary iron overload
Pandur Edina Dr.
18 Pathophysiology of Iron metabolism: hemochromatosis
Pandur Edina Dr.
19 Pathophysiology of Iron metabolism: therapeutic approaches
Pandur Edina Dr.
20 Iron disorders and Laboratory parameters 1.
Nagy Tamás Dr. II
21 Iron disorders and Laboratory parameters 2.
Nagy Tamás Dr. II
22 Iron and oxidative stress
Pandur Edina Dr.
23 Iron and immunity 1.
Pap Ramóna
24 Iron and immunity 2
. Pap Ramóna
25 Brain iron metabolism
Pandur Edina Dr.
26 The role of iron in neurodegenerative diseases
Pandur Edina Dr.
27 Iron and cancer 1.
Pandur Edina Dr.
28 Iron and cancer 2.
Pandur Edina Dr.
Practices
Seminars
Exam topics/questions
The questions will be formed from the learning material of the lectures.
Participants
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OPF-SKI-T BASICS OF CHEMICAL INFORMATICS
Course director: DR. GYŐZŐ KORNÉL KULCSÁR, assistant professor
Department of Pharmaceutical Chemistry kulcsar.gyozo@gytk.pte.hu
1 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 4
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 3 – 15 Prerequisites: OPA-S1E-T completed
Topic
The aim of the course is to give the students a basic knowledge of chemical informatics. An overview of how computers have become
the indispensable tools for chemical experiments, measurements, regulatory and performance evaluation tasks, and theoretical chemistry
tests.
We cover the chemical sciences from used software, web resources, which we believe are most useful during academic years in chemical
science student work and in preparing theses. Students can learn the basics of molecular modeling, the use of databases available in the
University (ScienceDirect, PubMed, SciFinder ...), the general steps of the search.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation in the lectures is obligatory.
Maximum three absences can be accepted.
Making up for missed classes
There is no opportunity to make up missed classes.
Reading material
- Obligatory literature
- Literature developed by the Department
The worksheets will be handed on the seminars.
- Notes
- Recommended literature
https://docs.chemaxon.com/display/docs/MarvinSketch+User%27s+Guide
http://www.cambridgesoft.com/support/DesktopSupport/Documentation/Manuals/files/chemdraw_9_english.pdf
Lectures
1 Introduction, simple database managers (literature, citations, etc.) in chemistry.
Dr. Kulcsár Győző Kornél
2 Introduction into the Molecular Modeling Software”s
Dr. Kulcsár Győző Kornél
3 Molecular modeling - structural fundamentals
Dr. Kulcsár Győző Kornél
4 Molecular modeling - structure optimization
Dr. Kulcsár Győző Kornél
5 Molecular modeling - molecules and interaction with the surroundings
Dr. Kulcsár Győző Kornél
6 Molecular modeling - molecular Interactions
Dr. Kulcsár Győző Kornél
7 Molecular modeling - applied modeling in drug research
Dr. Kulcsár Győző Kornél
8 Chemical databases I.
Dr. Kulcsár Győző Kornél
9 Chemical databases II.
Dr. Kulcsár Győző Kornél
10 Using a text editor application in chemistry
Dr. Kulcsár Győző Kornél
11 Handling bibliography
Dr. Kulcsár Győző Kornél
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12 Apply a spreadsheet program in chemistry
Dr. Kulcsár Győző Kornél
13 Apply a vector drawing program. Creating a flowchart of science, chemical content and flow charts. Photos and videos in
chemistry, the basics of image processing.
Dr. Kulcsár Győző Kornél
14 Presentation of student results, evaluation of the semester
Dr. Kulcsár Győző Kornél
Practices
Seminars
Exam topics/questions
Written test covering the topics of the lectures.
Participants
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OPF-CSU-T MIRACLES OF LIVING MATERIALS ("REALISTIC" BIOCHEMISTRY)
Course director: DR. BALÁZS VERES, associate professor
Department of Biochemistry and Medical Chemistry balazs.veres@aok.pte.hu
1 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 4
Number of hours/semester: 12 lectures + 0 practices + 0 seminars = total of 12 hours
Course headcount limitations (min.-max.): 5 – 45 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
The aim of the course is to enlighten and uncover the biochemical background of those topics which are selected as recent „mainstream”
natural science issues. The topic spectrum is wide enough to cover problems from synthetic biology through dopes in sport until toxins
and poisons of plants, fungi and animals. There is a special session about the physical, chemical and medical Nobel prizes from the last
decade to get insight to the hottest fields of natural sciences.
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
Making up for missed classes
There is no possibility to make up.
Reading material
- Obligatory literature
- Literature developed by the Department
Lecture slides (in pdf format) will be available for the students. WEB links and additional on line materials will be included as well.
- Notes
Lecture slides (in pdf format) will be available for the students. WEB links and additional on line materials will be included as well.
- Recommended literature
Lecture slides (in pdf format) will be available for the students. WEB links and additional on line materials will be included as well.
Lectures
1 Human genome project, gene therapy, epigenetics
Dr. Veres Balázs
2 DNA sequencing, PCR, CSI
Dr. Veres Balázs
3 Playing God: synthetic biology
Dr. Veres Balázs
4 You are what you eat: GMO
Dr. Veres Balázs
5 Superman: doping in sport and brain doping
Dr. Veres Balázs
6 Dependence: biochemistry of alcohol and drugs
Dr. Veres Balázs
7 Falling down: apoptosis, necrosis, autophagy
Dr. Veres Balázs
8 Cancer, AIDS: beyond therapy
Dr. Veres Balázs
9 Biochemistry of neurodegenerative disorders
Dr. Veres Balázs
10 Antibiotics: past, present, future
Dr. Veres Balázs
11 Home delivery: nanoparticles, liposomes
Dr. Veres Balázs
12 Nature strikes back: toxins of plants, fungi and animals
Dr. Veres Balázs
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Practices
Seminars
Exam topics/questions
Exam topics are the topics of the lectures during the course.
Participants
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OPF-TG2-T STUDENT PROJECT RESEARCH FOR STUDENTS OF PHARMACEUTIST PROGRAMME 2
Course director: DR. GYÖRGYI HORVÁTH, associate professor
Department of Pharmacognosy gyorgyi.horvath@aok.pte.hu
2 credit ▪ midsemester grade ▪ Optional subject for the Pharm. theor. and pract. skills module ▪ spring semester ▪ recommended semester: 4
Number of hours/semester: 0 lectures + 24 practices + 0 seminars = total of 24 hours
Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPF-TG1-T completed
Topic
The course aims at promoting of students to make student research projects on the field of pharmaceutical sciences. Furthermore, we
wish to give individual possibilities of students to perform experiments in the different pharmaceutical institutes involved into Students’
Research Society.
Conditions for acceptance of the semester
The continuous student’s work is recommended. The continuous enrollment of consecutive courses can be stopped and continued in
further semesters.
The prerequisite of this course (TDK 2): registration of the student in the database of Students’ Research Society and the fulfillment of
the Student Project Research for Students of Pharmaceutist Programme 1 course.
Mid-term exams
- Introduction of conference abstract or conference manuscript (student is co-author) for the course supervisor at the end of 13th week of
the semester.
- Written report on the work performed by the student. It must be sent to the course supervisor at the end of 13th week of the semester.
- Among the two conditions, one of them should be made at least.
Making up for missed classes
There is no possibility.
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
ScienceDirect database
Lectures
Practices
1-24 Research.
Seminars
Exam topics/questions
Not applicable.
Participants
Dr. Horváth Györgyi (GDLTCH)
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OPE-EFA-T ETHNOPHARMACOBOTANY
Course director: DR. NÓRA PAPP, associate professor
Department of Pharmacognosy nora4595@gamma.ttk.pte.hu
2 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ autumn semester ▪ recommended semester: 5
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 4 – 20 Prerequisites: OPO-G1E-T completed + OPO-G2E-T completed
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
Several written sources are available on the ethnobotanical usage and pharmaceutical history of medicinal plants from the Ancient Times.
The course presents a summary about ethnobotanical data focusing on folk therapeutical methods and values of the Mediterranean area,
Transylvania, countries of Europe, Asia, America and Africa completed by the scientific activity and curriculum vitae of ethnobotanists
and researchers in this topic. Students receive a general approach about the rules and regularity of the special folk terminology, practice,
folk customs and symbols in consideration of medicinal plants. In addition to ethnobotanical methods, the actual state, position and
necessity of surveys are discussed during the course.
Conditions for acceptance of the semester
Satisfactory fulfilment of 2 written tests based on the lectures.
Absences: according to the Code of Studies and Examinations of the Medical School.
Mid-term exams
The required 2 tests can be retaken or corrected in the course.
Making up for missed classes
Downloading lectures.
Reading material
- Obligatory literature
- Literature developed by the Department
http://aok.pte.hu/en/egyseg/oktatasianyagok/1640
http://gytk.pte.hu/en/egyseg/oktatasianyagok/1640
- Notes
- Recommended literature
Cunninham A. B.: Applied Ethnobotany. People, Wild Plant Use and Conservation, Earthscan, London, 2002
Ellen, Davi E., Hatfield, G.: Medicinal Plants in Folk Tradition an Ethnobotany of Britain and Ireland, Timber Press, Portland,
Cambridge, 2004
Lise Manniche: The Ancient Egyptian Herbal, The British Museum Press, London, 1989
Martin G. J.: Ethnobotany. A Methods Manual, Earthscan, London, 2007
Minnis P. E.: Ethnobotany. A Reader, University of Oklahoma Press, U.S.A., 2000
Moerman, Daniel E.: Native American Ethnobotany, Timber Press, Portland, London, 2010
Paye, Gabriell DeBear: Cultural Uses of Plants, The New York Botanical Garden Press, Bronx, New York, 2000
Lectures
1 Ethnopharmacological data of the Ancient Times (Egypt, Mesopotamia).
Dr. Papp Nóra
2 Ethnopharmacological data of the Ancient Times (Egypt, Mesopotamia).
Dr. Papp Nóra
3 Ethnobotanical studies of the Native Indian populations of North, South and Central America (Cuba, Mexico).
Dr. Papp Nóra
4 Ethnobotanical studies of the Native Indian populations of North, South and Central America (Cuba, Mexico).
Dr. Papp Nóra
5 Ethnopharmacology of the ancient cultures of Iran, China, India, Tibet, Japan.
Dr. Papp Nóra
6 Ethnopharmacology of the ancient cultures of Iran, China, India, Tibet, Japan.
Dr. Papp Nóra
7 Ethnopharmacology of African and Mediterranean countries (Greece, Spain, Portugal, Italy).
Dr. Papp Nóra
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8 Ethnopharmacology of African and Mediterranean countries (Greece, Spain, Portugal, Italy).
Dr. Papp Nóra
9 Ethnopharmacological data from the Middle Ages: therapy and medicinal plants in monastery gardens.
Dr. Papp Nóra
10 Ethnopharmacological data from the Middle Ages: therapy and medicinal plants in monastery gardens.
Dr. Papp Nóra
11 Transylvanian ethnobotanical values.
Dr. Papp Nóra
12 Transylvanian ethnobotanical values.
Dr. Papp Nóra
13 Written test I.
Dr. Papp Nóra
14 Written test I.
Dr. Papp Nóra
15 Ancient medico-botanical and herbal books and written sources with the morphological and therapeutical description of medicinal
plants.
Dr. Papp Nóra
16 Ancient medico-botanical and herbal books and written sources with the morphological and therapeutical description of medicinal
plants.
Dr. Papp Nóra
17 Scientific activity and curriculum vitae of ethnobotanists.
Dr. Papp Nóra
18 Scientific activity and curriculum vitae of ethnobotanists.
Dr. Papp Nóra
19 Methodologies in ethnobotanical collection.
Dr. Papp Nóra
20 Methodologies in ethnobotanical collection.
Dr. Papp Nóra
21 Interactive lecture: analysis and elaboration of scientific articles published in international journals and books based on the
knowledge and view of the previous lectures.
Dr. Papp Nóra
22 Interactive lecture: analysis and elaboration of scientific articles published in international journals and books based on the
knowledge and view of the previous lectures.
Dr. Papp Nóra
23 Traditional and folk terminology in plant names.
Dr. Papp Nóra
24 Traditional and folk terminology in plant names.
Dr. Papp Nóra
25 Documentation of ethnobotanical data - case studies
Dr. Papp Nóra
26 Documentation of ethnobotanical data - case studies
Dr. Papp Nóra
27 Written test II.
Dr. Papp Nóra
28 Written test II.
Dr. Papp Nóra
Practices
Seminars
Exam topics/questions
According to the topics of the course.
Participants
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OPE-TG3-T STUDENT PROJECT RESEARCH FOR STUDENTS OF PHARMACEUTIST PROGRAMME 3
Course director: DR. GYÖRGYI HORVÁTH, associate professor
Department of Pharmacognosy gyorgyi.horvath@aok.pte.hu
2 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ both semesters ▪ recommended semester: 5
Number of hours/semester: 0 lectures + 24 practices + 0 seminars = total of 24 hours
Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPF-TG2-T completed
Topic
The course aims at promoting of students to make student research projects on the field of pharmaceutical sciences. Furthermore, we
wish to give individual possibilities of students to perform experiments in the different pharmaceutical institutes involved into Students’
Research Society.
Conditions for acceptance of the semester
The continuous student’s work is recommended. The continuous enrollment of consecutive courses can be stopped and continued in
further semesters.
The prerequisite of this course (TDK 3): registration of the student in the database of Students’ Research Society and the fulfillment of
the Student Project Research for Students of Pharmaceutist Programme 2 course.
Mid-term exams
- Introduction of conference abstract or conference manuscript (student is co-author) for the course supervisor at the end of 13th week of
the semester.
- Introduction of original article published in national and/or international journals (student is co-author) at the end of 13th week of the
semester.
- Participation on Students’ Research Conference.
- Among the three conditions, one of them should be made at least.
Making up for missed classes
There is no possibility.
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
ScienceDirect database
Lectures
Practices
1-24 Research.
Seminars
Exam topics/questions
Not applicable.
Participants
Dr. Horváth Györgyi (GDLTCH)
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OPE-GMK-T QUALITATIVE AND QUANTITATIVE ANALYSIS OF DRUGS FROM HUMAN TISSUE
Course director: DR. ÁGNES FARKAS, associate professor
Department of Pharmacognosy agnes.farkas@aok.pte.hu
2 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ autumn semester ▪ recommended semester: 5
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 3 – 50 Prerequisites: none
Topic
The course provides knowledge about the traceability of active pharmaceutical ingredients in various biological matrices. It discusses
sampling of biological matrices, sample preparation (extraction) methods [LLE, SPE, SPEC, SPME, MEPS], and various
chromatographic techniques [TLC, GC, LC] as well.
The course intends to present the CNS effects of active pharmaceutical ingredients, as well as drugs in the official investigation. The
sampling procedures and techniques are presented, as well as their official confidence circumstances.
The appearance of drug compounds and drugs in biological matrices, and their pharmacokinetic properties are discussed, as well as
traceability of live and corpse biological matrices (blood, urine, hair, nails, saliva, or liver, kidney, brain, or cerebrospinal fluid).
After proper selection of analytical tests, the requirements set for a variety of measuring instruments will be discussed. Standard
evaluation and communication, as well as the laws and regulations in force in the analytical results complete the course topics.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Students have to prove their knowledge of the course material by presenting a selected topic in a short (10 min) talk. The topic should be
related to one of the topics of the course, and students should rely on their knowledge acquired in previous classes.
Making up for missed classes
According to the Code of Studies and Examinations
Reading material
- Obligatory literature
R.C. Baselt: Disposition of Toxic Drugs and Chemicals in Man, 6th ed., Biomedical Publications, Foster City, CA, 2002
A.C. Moffat, M.D. Osselton, B. Widdop: Clarke’s Analysis of Drugs and Poisons, Pharmaceutical Press, London, 2004.
- Literature developed by the Department
The Lecturer’s presentations (ppt files) will be available from the website of the Department of Pharmacognosy.
- Notes
- Recommended literature
R.J. Flanagan, A. Taylor, I.D. Watson, R. Whelpton: Fundamentals of Analytical Toxicology, John Wiley & Sons, Hoboken, NJ,
2007.
Lectures
1 Introduction to Toxicology. Categorization of Toxins I
Dr. Benkő András Antal
2 Introduction to Toxicology. Categorization of Toxins II
Dr. Benkő András Antal
3 Effect of Poisons on the Living Body I
Dr. Benkő András Antal
4 Effect of Poisons on the Living Body II
Dr. Benkő András Antal
5 Investigation in Forensic Laboratories. Sampling rules. I
Dr. Benkő András Antal
6 Investigation in Forensic Laboratories. Sampling rules. II
Dr. Benkő András Antal
7 Investigation of Non-standard Human Tissues I
Dr. Benkő András Antal
8 Investigation of Non-standard Human Tissues II
Dr. Benkő András Antal
9 Biological Materials Preparation. Extraction Procedures I
Dr. Benkő András Antal
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10 Biological Materials Preparation. Extraction Procedures II
Dr. Benkő András Antal
11 Forensic Toxicological Investigation of Human Samples by Chromatography I
Dr. Benkő András Antal
12 Forensic Toxicological Investigation of Human Samples by Chromatography II
Dr. Benkő András Antal
13 Criteria and Evaluation. Expert Opinion in Forensic Toxicology I
Dr. Benkő András Antal
14 Criteria and Evaluation. Expert Opinion in Forensic Toxicology II
Dr. Benkő András Antal
15 Natural Cannabinoids (marihuana, hashish, and hashish oil) I
Dr. Benkő András Antal
16 Natural Cannabinoids (marihuana, hashish, and hashish oil) II
Dr. Benkő András Antal
17 Synthetic Cannabino-mimetics (spice, pot-puri, herbal, bio-grass, K2) I
Dr. Benkő András Antal
18 Synthetic Cannabino-mimetics (spice, pot-puri, herbal, bio-grass, K2) II
Dr. Benkő András Antal
19 First Generation of Amphetamines (ecstasy, speed)
Dr. Benkő András Antal
20 Second generation of disco drugs (catinon and derivatives)
Dr. Benkő András Antal
21 Opiates (morphine, codeine, heroine) I
Dr. Benkő András Antal
22 Opiates (morphine, codeine, heroine) II
Dr. Benkő András Antal
23 Cocaine
Dr. Benkő András Antal
24 Body-pack Syndrome.
Dr. Benkő András Antal
25 Final Student ppt Presentation I
Dr. Benkő András Antal
26 Final Student ppt Presentation II
Dr. Benkő András Antal
27 Final Student ppt Presentation III
Dr. Benkő András Antal
28 Final Student ppt Presentation IV
Dr. Benkő András Antal
Practices
Seminars
Exam topics/questions
10 min ppt presentation based on an international forensic science article
Participants
Dr. Benkő András Antal (VF70AV)
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OPF-MOD-T MOLECULAR DIAGNOSTICS
Course director: DR. JUDIT ERZSÉBET PONGRÁCZ, professor
Department of Pharmaceutical Biotechnology pongracz.e.judit@pte.hu
1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 5
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 5 – 150 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
Structure of a molecular genetic laboratory, working areas, special devices and instrumentation. Biological information.
Conditions for acceptance of the semester
According to the Code of Studies and Examinations
Mid-term exams
Writing test
Making up for missed classes
According to the Code of Studies and Examinations
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
www.medbiotech.com
- Recommended literature
Lectures
1 Structure of a molecular genetic laboratory, working areas, special devices and instrumentation. Biological information.
Dr. Pongrácz Judit Erzsébet
2 Mutations, polymorphisms. The genetic code.
Dr. Pongrácz Judit Erzsébet
3 Mutations, polymorphisms. The genetic code.
Dr. Pongrácz Judit Erzsébet
4 Special mutation consequences.
Dr. Pongrácz Judit Erzsébet
5 Dynamic mutations.
Dr. Pongrácz Judit Erzsébet
6 Mendelian inheritance.
Dr. Pongrácz Judit Erzsébet
7 Multifactorial diseases.
Dr. Pongrácz Judit Erzsébet
8 Examples for monogenic diseases.
Dr. Pongrácz Judit Erzsébet
9 Examples for monogenic diseases.
Dr. Pongrácz Judit Erzsébet
10 Examples for monogenic diseases.
Dr. Pongrácz Judit Erzsébet
11 Pharmacogenetics.
Dr. Pongrácz Judit Erzsébet
12 Molecular testing in oncology.
Dr. Pongrácz Judit Erzsébet
13 Methodology of the molecular diagnostic procedures.
Dr. Pongrácz Judit Erzsébet
14 Methodology of the molecular diagnostic procedures.
Dr. Pongrácz Judit Erzsébet
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Practices
Seminars
Exam topics/questions
www.medbiotech.com
Participants
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OPF-MME-T MOLECULAR MEDICINE
Course director: DR. JUDIT ERZSÉBET PONGRÁCZ, professor
Department of Pharmaceutical Biotechnology pongracz.e.judit@pte.hu
1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 5
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 5 – 150 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
Introduction into molecular medicine
Conditions for acceptance of the semester
According to the Code of Studies and Examinations
Mid-term exams
Writing test
Making up for missed classes
None
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
www.medbiotech.com
- Recommended literature
Lectures
1 Introduction into molecular medicine
Dr. Pongrácz Judit Erzsébet
2 The genome
Dr. Pongrácz Judit Erzsébet
3 Sequencing of the genome
Dr. Pongrácz Judit Erzsébet
4 Investigation of the human genome with microarrays
Dr. Pongrácz Judit Erzsébet
5 Genes and diseases
Dr. Pongrácz Judit Erzsébet
6 Nuclear receptors
Dr. Pongrácz Judit Erzsébet
7 Personalized genetics
Dr. Pongrácz Judit Erzsébet
8 Immunodeficiencies
Dr. Pongrácz Judit Erzsébet
9 Cancers (introduction)
Dr. Pongrácz Judit Erzsébet
10 Molecular mechanisms of cancer development
Dr. Pongrácz Judit Erzsébet
11 Obesity: introduction
Dr. Pongrácz Judit Erzsébet
12 Genomics of obesity
Dr. Pongrácz Judit Erzsébet
13 Genes involved in development of obesity
Dr. Pongrácz Judit Erzsébet
14 Therapeutic approaches to obesity. Interconnected mechanisms in lipid metabolism
Dr. Pongrácz Judit Erzsébet
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Practices
Seminars
Exam topics/questions
www.medbiotech.com
Participants
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125
OPF-MOT-T MOLECULAR THERAPIES
Course director: DR. JUDIT ERZSÉBET PONGRÁCZ, professor
Department of Pharmaceutical Biotechnology pongracz.e.judit@pte.hu
1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 5
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 5 – 150 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
Gene therapy, in vivo gene therapy
Conditions for acceptance of the semester
According to the Code of Studies and Examinations
Mid-term exams
Writing test
Making up for missed classes
None
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
www.medbiotech.com
- Recommended literature
Lectures
1 Functional genomics I
Dr. Pongrácz Judit Erzsébet
2 Functional genomics II
Dr. Pongrácz Judit Erzsébet
3 Recombinant protein expression
Dr. Pongrácz Judit Erzsébet
4 Gene therapy, in vivo gene therapy
Dr. Pongrácz Judit Erzsébet
5 Ex vivo gene therapy, Therapies based on protein replacement I
Dr. Pongrácz Judit Erzsébet
6 Therapies based on protein replacement II
Dr. Pongrácz Judit Erzsébet
7 Recombinant antibodies and phage phage display technique
Dr. Pongrácz Judit Erzsébet
8 Anti-cytokine therapy (Sepsis)
Dr. Pongrácz Judit Erzsébet
9 Transgene technology and mouse models in modern biological research
Dr. Pongrácz Judit Erzsébet
10 Embryonic and adult stem cells for regenerative medicine I
Dr. Pongrácz Judit Erzsébet
11 Embryonic and adult stem cells for regenerative medicine II
Dr. Pongrácz Judit Erzsébet
12 Cell cycle and cancer therapy, p53 I
Dr. Pongrácz Judit Erzsébet
13 Cell cycle and cancer therapy, p53 II
Dr. Pongrácz Judit Erzsébet
14 Gene silencing technologies
Dr. Pongrácz Judit Erzsébet
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Practices
Seminars
Exam topics/questions
www.medbiotech.com
Participants
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OPF-HVS-T SYNTHESIS OF HETEROCYCLIC COMPOUNDS AND THEIR APPLICATION IN THERAPY
Course director: DR. TAMÁS KÁLAI, professor
Department of Pharmaceutical Chemistry tamas.kalai@aok.pte.hu
2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 5
Number of hours/semester: 0 lectures + 0 practices + 28 seminars = total of 28 hours
Course headcount limitations (min.-max.): 1 – 12 Prerequisites: OPA-S1E-T completed
Topic
Heterocyclic chemistry is an important subdivision of organic chemistry, as 70% of all medicines are heterocyclic compound or contains
a heterocyclic moiety. This course will give an introduction to, and the summary of, the most important principles and ideas of
heterocyclic chemistry. This course partially re-calls the knowledge of Organic chemisty 1 and Organic chemistry 2 course, discusses
those details which were not reflected on, because of time shortage and supports to evaluate the pharmacological chemistry subject.
-Electronic structure of heterocycles
-Nomenclature of heterocyclic compounds
-Main synthetic routes to heterocyclic compounds, Saturated heterocycles, occurence of heterocycles
-Three and four membered heterocycles (synthesis, reactions, occurence)
-The pyrrole and indole (synthesis, reactions, occurence)
-Furan, thiophene and their benzo derivatives.
-Five membered heterocycles with two or more heteroatoms: imidazole, oxazole, thiazole
-Pyrazole, isoxazole, isothiazole
-I. st test, Six-membered heterocycles with one oxygen heteroatom (piranes, chromones, flavones and coumarins)
-Six membered heterocycles with one nitrogen atom (pyridine, quinoline, isoquinoline)
-Six membered heterocycles with two or more heteroatoms (purine, diazines, triazines etc.)
-Seven membered heterocyclic chemistry
-Heterocycles in supramolecular chemitry
-Heterocyclic compounds in organic snthesis
-II nd test, short presntation on a paper on heterocyclic chemistry
-Evaluation
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
The students write two tests, at the middle of the semester and at the end of the semester. Every student have a chance to make a
presentation based on a heterocyclic chemistry paper for an extra grade.
Making up for missed classes
Personal communication. The english program student might visit the paralell hungarian course to catch up the main reaction equations.
Reading material
- Obligatory literature
Li, J. J. Hetrocyclic chemistry in Drug Discovery, Wiley
- Literature developed by the Department
Slides will be given to students as a ppt or pdf files.
- Notes
Joule, J. J.; Mills, K. Heterocyclic chemistry at a Glance. (Wiley)
- Recommended literature
Li, J. J. Top 10 drugs Oxfors University Press
Lectures
Practices
Seminars
1 Electronic structure of heterocycles, nomenclature of heterocycles
2 Occurence of heterocyclic compounds
3 Synthesis of heterocycles
4 Common reaction types in heterocyclic chemistry
5 Tautomerism in heterocyclic chemistry
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6 Saturated heterocycles
7 Three and four membered heterocycles, beta lactams
8 Three and four-membered heterocycles and beta lactams
9 Synthesis of pyrroles and porfirine ring containing compounds
10 Synthesis of indoles, main reactions of indoles.
11 Furans and thiophenes
12 Thiophenes and benzothiophenes
13 1,2-azoles, their synthesis, reactions and their occurence in drugs
14 1,3-azoles, their synthesis, reactions, occurence in drugs
15 1st test (generral feature of heterocyclic compounds (3-, 4-, 5-membered heterocycles)
16 Six membered heterocycles containing oxygen heteroatom
17 Pyridines (synthesis, reactions, occurence in drugs and biomolecules)
18 Quinolines, isoquinolines (synthesis, reactions, occurence in drugs)
19 Synthesis of pyrimidines and their occurence in medicines
20 Synthesis and reactions of 1,2- and 1,4-diazines
21 Synthesis and reactions of triazines and purines
22 Heterocycles of life and death
23 Seven membered heterocycles their occurence, synthesis, applications in therapy
24 IInd test, short presentations on papers on heterocyclic chemistry, evaluation
25 Heterocycles in supramolecular chemistry
26 Heterocycles in organic synthesis
27 2nd test (6- and 7-membered heterocycles)
28 Short presentations, evaluations
Exam topics/questions
-Electronic structure of heterocycles
-Nomenclature of heterocyclic compounds
-Main synthetic routes to heterocyclic compounds
-Saturated heterocycles
-Three and four membered heterocycles (synthesis, reactions, occurence)
-The pyrrole and indole (synthesis, reactions, occurence)
-Furan, thiophene and their benzo derivatives.
-Five membered heterocycles with two or more heteroatoms
-Six-membered heterocycles with one oxygen heteroatom (piranes, chromones, flavones and coumarins)
-Six membered heterocycles with one nitrogen atom (pyridine, quinoline, isoquinoline)
-Six membered heterocycles with two or more heteroatoms (purine, diazines etc.)
-Seven membered heterocyclic chemistry
- Heterocycles in supramolecular chemitry
-Heterocyclic compounds in organic snthesis
Participants
Dr. Kálai Tamás (BDF5M9)
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OPF-GLK-T BIOINORGANIC CHEMISTRY FOR PHARMACY STUDENTS
Course director: DR. IMRE HUBER, associate professor
Department of Pharmaceutical Chemistry imre.huber@aok.pte.hu
1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 5
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 5 – 15
Prerequisites: OPA-T2E-T completed + OPA-S2E-T completed + OPO-GE2-T completed
Topic
We will provide an overview in this block about bioinorganic topics of chemistry, regarding the role of the different elements in medicinal
and pharmaceutical chemistry. Our aim is to offer a concise knowledge also about bioinorganic relations on medical contrast agents like
X-ray, tomographic, MR and ultrasound contrast agents. The use of radionuclids in diagnostical methods will be discussed too.
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
Students will have to write a written test at the end of the semester.
Making up for missed classes
In case of absences the students must follow up with self-education!
Reading material
- Obligatory literature
- Literature developed by the Department
Lecture notes provided by the lecturer.
- Notes
- Recommended literature
Lectures
1 Introduction, The biological importance of non-metals and metals.
Dr. Huber Imre
2 An overview of the elements.
Dr. Huber Imre
3 Rtg-contrast agents.
Dr. Huber Imre
4 Watersoluble nephrothrop Rtg-contrast agents with high osmolality.
Dr. Huber Imre
5 Watersoluble nephrothrop Rtg-contrast agents with low osmolality.
Dr. Huber Imre
6 Watersoluble hepatothrop Rtg-contrast agents.
Dr. Huber Imre
7 Water-insoluble Rtg-contrast agents.
Dr. Huber Imre
8 Contrast agents for MRI.
Dr. Huber Imre
9 Contrast agents for CT.
Dr. Huber Imre
10 Contrast agents for ultrasound.
Dr. Huber Imre
11 Radioactive diagnostics (radionuclids).
Dr. Huber Imre
12 Platinum comlexes in medicin. Chelation therapy.
Dr. Huber Imre
13 Bisphosphonates in medicin.
Dr. Huber Imre
14 Geometry of complexes. Closing written test.
Dr. Huber Imre
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Practices
Seminars
Exam topics/questions
These are listed in the lecture notebook written by the lecturer. These notes are about the different questions of this field with the
corresponding answers, parallely.
Participants
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OPF-TS1-T CALCULATIONS IN PHARMACEUTICAL TECHNOLOGY 1
Course director: DR. SZILÁRD PÁL, assistant professor
Institute of Pharmaceutical Technology and Biopharmacy szilard.pal@aok.pte.hu
1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 5
Number of hours/semester: 0 lectures + 0 practices + 12 seminars = total of 12 hours
Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPG-C1E-T parallel + OPG-GI1-T completed
Topic
Aim of the course is to deepen the knowledge of calculations needed for Pharmaceutical Technology 1 practice (dose checking,
prescription reading and understanding) by solving and practicing several examples together with the course leader.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Participation on the seminars - accepted work reports - accepted written assessments Students have to write an end-semester assessment
from the lectures at acceptance level of 60%.
Making up for missed classes
Students must fulfil requirements determined by the Code of Studies and Examinations. Student has to make up the missed lectures and
do work reports.
Reading material
- Obligatory literature
- Literature developed by the Department
Seminar notes.
- Notes
- Recommended literature
European Pharmacopoeia
Formulae Normales VII. (FoNo VII.)
James Swarbrick: Encyclopedia of Pharmaceutical Technology, Informa Healthcare, New York, London
Gilbert S. Banker, Christopher T. Rhodes: Modern Pharmaceutics, Marcel Dekker Inc., New York- Basel
Chris Langley, Dawn Belcher: Pharmaceutical Compounding and Dispensing, Pharmaceutical Press
Attila Dévay: The Theory and Practice of Pharmaceutical Technology, electronic book, PTE-Pécs
Attila Dévay: Investigation of Pharmaceutical Preparations, electronic book, PTE-Pécs
Lectures
Practices
Seminars
1 Introduction to pharmaceutical technological calculations, praciticing and understanding expressions found on prescriptions
2 Concept of concentration
3 Basic calculations of clear solutions (mixing rule)
4 Calculations of ethanol dilution
5 Fundamentals of dose checking (understanding the prescription, syrup factor, elderly factor)
6 Dose checking in solutions 1.
7 Dose checking in solutions 2.
8 Dose checking in peroral drops 1.
9 Dose checking in peroral drops 2.
10 Calculation of isotonicity 1.
11 Calculation of isotonicity 2.
12 Test
Exam topics/questions
Students can get the test topics in the institute or download the from website of the institute.
Participants
Ámanné Dr. Takácsi-Nagy Anna (SEGAOR), Dr. Kása Péter (ISWPRM), Dr. Pál Szilárd (FYF5E9)
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OPF-GKG-T GAS CHROMATOGRAPHY
Course director: DR. VIKTÓRIA POÓR, assistant professor
Institute of Bioanalysis viktoria.poor@aok.pte.hu
1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 5
Number of hours/semester: 8 lectures + 4 practices + 0 seminars = total of 12 hours
Course headcount limitations (min.-max.): 4 – 15 Prerequisites: OPA-M1E-T completed
Topic
Key Topics
-practical theory about Gas Chromatography
-how to select and use the carrier gas
-various injection techniques and when to use each
-how to select a GC column
-the operation and selection of an appropriate GC detector
-how to write measuring methods
-how to undertake data analysis
-sampling techniques for GC
-strategies for method development
-introduction to GC & MS advanced techniques
-applications (pharmaceutical application)
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
1 test during the semester
1 oral presentation (based on research articles on the field of pharmaceutical apllication)
Making up for missed classes
There is no possibility for retake
Reading material
- Obligatory literature
Modern Analytical Cheymistry,David Harvey
- Literature developed by the Department
www.aok.pte.hu/bioanalitika
- Notes
- Recommended literature
Lectures
1 practical theory about Gas Chromatography
Dr. Poór Viktória
2 how to select and use the carrier gas
-various injection techniques and when to use each
Dr. Poór Viktória
3 how to select a GC column
-the operation and selection of an appropriate GC detector
Dr. Poór Viktória
4 strategies for method development
Dr. Poór Viktória
5 introduction to GC & MS advanced techniques
Dr. Poór Viktória
6 introduction to GC & MS advanced techniques
Dr. Poór Viktória
7 how to write measuring methods
Dr. Poór Viktória
8 how to undertake data analysis
Dr. Poór Viktória
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Practices
1 GC practice 1
2 GC practice 2
3 GC-MS 1.
4 GC-MS 2.
Seminars
Exam topics/questions
1 test during the semester
1 oral presentation (based on research articles on the field of pharmaceutical apllication)
Participants
Dr. Poór Viktória (MJELTX)
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OPF-EGZ-T EXOTIC MEDICINAL PLANTS
Course director: DR. KAMILLA ÁCS, assistant professor
Department of Pharmacognosy kamilla.acs@aok.pte.hu
2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 5
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 25 Prerequisites: OPO-G2E-T completed
Topic
The course includes 28 lectures. The aim of the course is to present the most frequently used exotic plants in the medical therapy. The
course gives a general overview about the botanical character, active ingredients, and drug part of the plants. Application forms and
safety instructions are also highlighted during the lectures. Herbs and drugs will presented according to their areas of application.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Oral presentation about a medicinal value of a selected plant. Fulfillment of the final test (minimum 60%).
Making up for missed classes
Downloading of lectures in Neptun.
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
Bremness L. (1988): The Complete Book of Herbs: A Practical Guide to Growing and Using Herbs.
Ratsch C., Hofmann A.(2007): The Encyclopedia of Psychoactive Plants: Ethnopharmacology and Its Applications.
Kane C.W. (2007): Medicinal Plants of the Western Mountain States
Bett J. (2015): Chinese Medicinal Plants: How To Grow Them, How To Use Them: Growing and Using Herbs And Plants For
Natural Remedies And Healing.
Lectures
1 Herbs of the gastrointestinal tract I.
Dr. Ács Kamilla
2 Herbs of the gastrointestinal tract II.
Dr. Ács Kamilla
3 Herbs of the gastrointestinal tract III.
Dr. Ács Kamilla
4 Herbs of the gastrointestinal tract IV.
Dr. Ács Kamilla
5 Aromatic plants and products containing essential oils I.
Dr. Ács Kamilla
6 Aromatic plants and products containing essential oils II.
Dr. Ács Kamilla
7 Aromatic plants and products containing essential oils III.
Dr. Ács Kamilla
8 Aromatic plants and products containing essential oils IV.
Dr. Ács Kamilla
9 Herbs and products containing fatty oils I.
Dr. Ács Kamilla
10 Herbs and products containing fatty oils II.
Dr. Ács Kamilla
11 Plants for external use, dermatology and cosmetics I.
Dr. Ács Kamilla
12 Plants for external use, dermatology and cosmetics II.
Dr. Ács Kamilla
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13 Plants which affect the central nervous system I.
Dr. Ács Kamilla
14 Plants which affect the central nervous system II.
Dr. Ács Kamilla
15 Plants for cardiovascular disorders I.
Dr. Ács Kamilla
16 Plants for cardiovascular disorders II.
Dr. Ács Kamilla
17 Plants for well-being I.
Dr. Ács Kamilla
18 Plants for well-being II.
Dr. Ács Kamilla
19 Psychoactive and hallucinogenic plants I.
Dr. Ács Kamilla
20 Psychoactive and hallucinogenic plants II.
Dr. Ács Kamilla
21 Plants with immunostimulant effect I.
Dr. Ács Kamilla
22 Plants with immunostimulant effect II.
Dr. Ács Kamilla
23 Plants for tropical, and contagious diseases I.
Dr. Ács Kamilla
24 Plants for tropical, and contagious diseases II.
Dr. Ács Kamilla
25 Presentations of students I.
Dr. Ács Kamilla
26 Presentations of students II.
Dr. Ács Kamilla
27 Exam
Dr. Ács Kamilla
28 Exam
Dr. Ács Kamilla
Practices
Seminars
Exam topics/questions
It is similar to the topics of lectures.
Participants
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ATT5-T PHYSICAL EDUCATION 5
Course director: ISTVÁN KARSAI, senior lecturer
UP MS Sports Facilities istvan.karsai@aok.pte.hu
0 credit ▪ signature ▪ Optional subject ▪ both semesters ▪ recommended semester: 5-6-7-8-9-10
Number of hours/semester: 0 lectures + 28 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 2 – 50 Prerequisites: ATT4-T completed
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
This subject provides theoretical and practical information for the students to maintain and improve their physical condition and helps to
deepen the knowledge in the field of healthy lifestyle.
Theoretical and practical knowledge during different types of exercises e.g. how to improve endurance, muscle force, motor skills and
how to prevent the body from injuries.
Conditions for acceptance of the semester
Active participation at least 20 practical lessons provided by the Institute of Human Movement Sciences or regular participation of the
trainings of the Medikus Sport Club or PEAC.
Mid-term exams
Making up for missed classes
We provide opportunities to attend extra lessons in the first week of the exam period in that case the requirements are not fulfilled till the
end of the teaching weeks with agreement of the PE Teacher.
Reading material
- Obligatory literature
- Literature developed by the Department
Not available.
- Notes
- Recommended literature
Lectures
Practices
1-28 For the list of actual courses please turn to the end of the 1st year’s obligatory subjects booklet
Seminars
Exam topics/questions
Participants
Farkas György (CL1MIY), Lipcsik Zoltán (EGE1AE), Németh Attila Miklós (EXB7TD), Téczely Tamás (P0OP8M)
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OPF-VGG-T COLLECTING AND CONSERVATION OF WILD NATIVE MEDICINAL PLANTS
Course director: DR. DRAGICA PURGER, assistant professor
Department of Pharmacognosy dragica@gamma.ttk.pte.hu
2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 5
Number of hours/semester: 24 lectures + 4 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 20 Prerequisites: OPO-G2E-T completed + OPO-G2G-T completed
Topic
Collecting and conservation of wild native medicinal plants is an elective course that will help in obtaining wider knowledge related to
medicinal plants. The topic covers wild medicinal plants native to Hungary, their morphological description, their occurrence and
significance. It describes in detail the methodology and possibilities for collecting wild medicinal plants in nature, and discusses strategies
for the conservation of rare and endangered herb species. The course includes a half-day field trip to Pécs-Nagyarpád, where the main
focus is on the recognition of native wild medicinal plants in nature. The students can broaden their knowledge related to wild medicinal
plants and their application in pharmacist practice.
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
Written test
Making up for missed classes
Upon individual agreement. Field practices cannot be missed or made up for.
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
Shi Lin Chen et al. 2016: Conservation and sustainable use of medicinal plants: problems, progress, and prospects. Chin Med 11:37
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967523/pdf/13020_2016_Article_108.pdf)
Danna J. Leaman: Sustainable wild collection of medicinal and aromatic plants. Development of an international standard
https://library.wur.nl/frontis/medicinal_aromatic_plants/07_leaman.pdf
Medicinal Plant Specialist Group Species Survival Commission IUCN 2007: International Standard for Sustainable Wild Collection
of Medicinal and Aromatic Plants (ISSC-MAP) Version 1.0- The World Conservation Union
https://www.bfn.de/fileadmin/MDB/documents/service/skript195.pdf
Lectures
1 Importance of wild medicinal plants
Dr. Purger Dragica
2 Collection of wild medicinal plants in Hungary; historical overview
Dr. Purger Dragica
3 Methods of the collection of wild medicinal plants
Dr. Purger Dragica
4 Methods of the collection of wild medicinal plants
Dr. Purger Dragica
5 National and regional databases of wild medicinal plants
Dr. Purger Dragica
6 Collection Calendar
Dr. Purger Dragica
7 Primary processing of collected medicinal plants
Dr. Purger Dragica
8 Primary processing of collected medicinal plants
Dr. Purger Dragica
9 General quality requirements
Dr. Purger Dragica
10 General quality requirements
Dr. Purger Dragica
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11 International conventions and rules
Dr. Purger Dragica
12 International conventions and rules
Dr. Purger Dragica
13 Estimating the population size of medicinal plants
Dr. Purger Dragica
14 Estimating the population size of medicinal plants
Dr. Purger Dragica
15 Endangered, protected and strictly protected native medicinal plants
Dr. Purger Dragica
16 Endangered, protected and strictly protected native medicinal plants
Dr. Purger Dragica
17 Monitoring populations of threatened species
Dr. Purger Dragica
18 Monitoring populations of threatened species
Dr. Purger Dragica
19 Strategies for conservation of endangered medicinal plants
Dr. Purger Dragica
20 Strategies for conservation of endangered medicinal plants
Dr. Purger Dragica
21 The role of botanical gardens in ex situ preserving of medicinal plants
Dr. Purger Dragica
22 The role of botanical gardens in ex situ preserving of medicinal plants
Dr. Purger Dragica
23 Exam: Written test
Dr. Purger Dragica
24 Exam: Written test
Dr. Purger Dragica
Practices
1 General information on plant parts collected
2 The most important wild native medicinal plants in Hungary, their habitats and distribution
3 Collecting wild medicinal plants in the field
4 Collecting wild medicinal plants in the field
Seminars
Exam topics/questions
1. Importance of wild medicinal plants
2. Collection of wild medicinal plants
3. Methods of the collection of wild medicinal plants
4. The most important wild native medicinal plants in Hungary
5. Collecting wild medicinal plants in the field
6. Collection Calendar
7. Primary processing of collected medicinal plants
8. General quality requirements
9. International conventions and rules
10. Estimating the population size of medicinal plants
11. Endangered, protected and strictly protected native medicinal plants
12. Monitoring populations of threatened species
13. Strategies for conservation of endangered medicinal plants
14. The role of botanical gardens in ex situ preserving of medicinal plants
Participants
Dr. Purger Dragica (FCCWBF)
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OPF-GMT-T DRUG METABOLISM AND DRUG TOXICITY
Course director: DR. ATTILA ALMÁSI, assistant professor
Department of Pharmaceutical Chemistry attila.almasi@aok.pte.hu
1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 5
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 3 – 50 Prerequisites: OPO-G1B-T completed
Topic
On the seminaries of this facultative course the molecular background and the influenceability of the side and toxic effects of different
drugs are aimed, during the drug absorption, drug transformation and drug elimination.
During the course, the metabolic activation and transformation of the environmental carcinogens are to be discussed.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
In the end of the semester the students write an end-semester test. The test is evaluated in percentage and the final grade is to be established
based on this result. The result of the test should be above 60%.
Making up for missed classes
The replacement of the missed test is required.
Reading material
- Obligatory literature
- Literature developed by the Department
Slides of the lectures.
- Notes
- Recommended literature
Lectures
1 Introduction. The toxicological aspects of drug metabolism.
Dr. Almási Attila
2 Characteristics of xenobiotics in the body
Dr. Almási Attila
3 Metabolic transformation I. Phase I. or functionalisation reactions 1 (CYP enzymes).
Dr. Almási Attila
4 Metabolic transformations II. Phase I. or functionalisation reactions 2 (FAD enzymes and non microsomal transformations).
Dr. Almási Attila
5 Metabolic transformations III. Phase II. or conjugation reactions 1 ( glucuronic acid conjugation, sulphate conjugation).
Dr. Almási Attila
6 Metabolic transformations IV. Phase II. or conjugation reactions 2 ( amino acid conjugation, acetylation, methylation, gluthatione
conjugation).
Dr. Almási Attila
7 Phase III. transformations (transporters), general molecular mechanism of drug toxicity.
Dr. Almási Attila
8 Biotransformation and the toxic effects of the paracetamol. Factors influence the toxicity of the paracetamol.
Dr. Almási Attila
9 Toxicity of the non-steroid antiinflammatory drugs (NSAIDs). Hepatotoxic effect of the diclofenac.
Dr. Almási Attila
10 Toxicity of the troglitazone. Sulfonamide hypersensitivity.
Dr. Almási Attila
11 Chemical carcinogenesis I., Definition, cell division, environmental carcinogens, chemical carcinogenesis.
Dr. Almási Attila
12 Chemical carcinogenesis II., Structure and metabolic activation of environmental carcinogens.
Dr. Almási Attila
13 Metabolic differences between species, genetic polymorphism.
Dr. Almási Attila
14 Changes in drug metabolism during pregnancy and at aged people.
Dr. Almási Attila
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Practices
Seminars
Exam topics/questions
Based on the announced thesis list.
Participants
Dr. Almási Attila (KJ5MBZ)
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OPE-STK-T BASICS OF STEREOCHEMISTRY
Course director: DR. IMRE HUBER, associate professor
Department of Pharmaceutical Chemistry imre.huber@aok.pte.hu
1 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ spring semester ▪ recommended semester: 6
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 5 – 15
Prerequisites: OPA-S2E-T completed + OPG-R1E-T completed + OPO-GE2-T completed
Topic
In the frame of this topic we will provide an overview about fundamentals of stereochemical definitions and processes. The students will
receive the most important knowledge about stereochemistry, with what they can understand the different binding types of drugs to their
place of biological action.
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
Students will have to write a written test at the end of the semester.
Making up for missed classes
In case of absences the students must follow up with self-education!
Reading material
- Obligatory literature
- Literature developed by the Department
Lecture notes provided by the lecturer.
- Notes
Lecture notes provided by the lecturer.
- Recommended literature
K.-H. Hellwich, C. D. Siebert: Stereochemistry workbook, 191 problems and solutions, Springer, 2006.
Lectures
1 Introduction, confoguration, conformation definitions.
Dr. Huber Imre
2 Chirality, asymmetry.
Dr. Huber Imre
3 Asymmetric syntheses
Dr. Huber Imre
4 Fischer projection, CIP system.
Dr. Huber Imre
5 Diastereomers, enantiomers.
Dr. Huber Imre
6 Epimers, eutomers, distomers.
Dr. Huber Imre
7 Homochirality, inversion, meso-isomers.
Dr. Huber Imre
8 Newman projection.
Dr. Huber Imre
9 Optical purity.
Dr. Huber Imre
10 Prochirality, prostereoisomerism.
Dr. Huber Imre
11 Racemate, racemisation.
Dr. Huber Imre
12 Retention in stereochemistry.
Dr. Huber Imre
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13 Stereoselectivity, stereospecificity.
Dr. Huber Imre
14 Summary, written test.
Dr. Huber Imre
Practices
Seminars
Exam topics/questions
These are listed in the lecture notebook written by the lecturer. These notes are about the different questions of this field with the
corresponding answers, parallely.
Participants
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OPF-SNA-T CARBON NANOSTRUCTURES
Course director: DR. BEÁTA LEMLI, assistant professor
Department of Organic and Pharmacological Chemistry beata.lemli@aok.pte.hu
2 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ spring semester ▪ recommended semester: 6
Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours
Course headcount limitations (min.-max.): 5 – 20 Prerequisites: OPG-R1E-T completed
Topic
Carbon is an indispensable element of life, thanks to the ability to form different chemical bonds with most elements of the periodic
table, enabling the creation of different and complex life forms. The discovery of the organic carbon compounds has been started in the
19th century, and now they are the part of our lives. Nowadays the previously discovered allotropes of carbon - fullerenes, carbon
nanotubes, graphenes, graphene nanoribbons - are in the focus, however, their real wide application still seems to be a big challenge and
needs further investigations. During this curse, students will be introduced to the promising pharmaceutical chemistry, medical and
biological applications of these materials and to the latest results of related research.
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
One written exam during the semester, the acceptance level is 60%. One oral presentation by students.
Making up for missed classes
There is no possibility to make up for a missed lecture and practice
Reading material
- Obligatory literature
Physical Biochemistry: Applications to Biochemistry and Molecular Biology (Life Sciences/Biochemistry) by David M. Freifelder,
2nd Edition, ISBN-13: 978-0716714446, ISBN-10: 0716714442
- Literature developed by the Department
The slides of the lectures are electronically available.
- Notes
- Recommended literature
Physical Biochemistry: Applications to Biochemistry and Molecular Biology (Life Sciences/Biochemistry) by David M. Freifelder,
2nd Edition, ISBN-13: 978-0716714446, ISBN-10: 0716714442
Lectures
1 Introduction of the course requirements. Fullerenes, carbon nanostructure, graphene: their discovery, historical review
Dr. Lemli Beáta
2 Preparation, synthesis, cleaning, general properties
Dr. Lemli Beáta
3 Covalent and non-covalent functionalization of carbon nanomaterials
Dr. Lemli Beáta
4 Covalent and non-covalent functionalization of carbon nanomaterials
Dr. Lemli Beáta
5 Cellular uptake mechanism of carbon nanotubes
Dr. Lemli Beáta
6 Cellular uptake mechanism of carbon nanotubes
Dr. Lemli Beáta
7 Carbon nanotube biodistribution
Dr. Lemli Beáta
8 Carbon nanotube biodistribution
Dr. Lemli Beáta
9 Application of carbon nanocapsules in drug delivery
Dr. Lemli Beáta
10 Application of carbon nanocapsules in drug delivery
Dr. Lemli Beáta
11 Carbon nanotubes applied for in vitro, in vivo and in silico drug delivery
Dr. Lemli Beáta
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12 Carbon nanotubes applied for in vitro, in vivo and in silico drug delivery
Dr. Lemli Beáta
13 Carbon nanostructures and DNA
Dr. Lemli Beáta
14 Carbon nanostructures and DNA
Dr. Lemli Beáta
15 Novel strategies for cancer diagnosis and treatment
Dr. Lemli Beáta
16 Novel strategies for cancer diagnosis and treatment
Dr. Lemli Beáta
17 The toxicity of carbon nanomaterials
Dr. Lemli Beáta
18 The toxicity of carbon nanomaterials
Dr. Lemli Beáta
19 Outlook: about the nanomedicines and drug delivery nanosystems
Dr. Lemli Beáta
20 Student’s lecture.
Dr. Lemli Beáta
21 Written test.
Dr. Lemli Beáta
22 Written test.
Dr. Lemli Beáta
23 Summary and conclusions
Dr. Lemli Beáta
24 Summary and conclusions
Dr. Lemli Beáta
Practices
Seminars
Exam topics/questions
The topics of the written test are similar to the topics of the lectures.
Participants
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OPE-VFM-T BUSINESS DEVELOPMENT AND MANAGEMENT
Course director: DR. RITA BOGNÁR, research associate professor
Department of Biochemistry and Medical Chemistry rita.bognar@aok.pte.hu
2 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ spring semester ▪ recommended semester: 6
Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours
Course headcount limitations (min.-max.): 1 – 30 Prerequisites: none
Topic
The main objective of the course is to develop the business orientation skills of the students, while deepening their knowledge in business
models, business plans, innovative business strategies, time-, product-, process- and human resource management. Participants will have
the capability how to develop healthcare businesses in international environment and how to plan better their time.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
TVSZ szerint
Making up for missed classes
TVSZ szerint
Reading material
- Obligatory literature
- Literature developed by the Department
Neptun
- Notes
- Recommended literature
1. Baum Neil, Thomas Raju : The Basics of Business of Medicine, 2015
2. Helen Ewing: Healthcare Finance: An Introduction to Accounting and Financial Management, 5th edition, 2013
Lectures
1 Global healthcare
Dr. Bognár Rita
2 Different healthcare systems
Dr. Bognár Rita
3 Regional healthcare
Dr. Bognár Rita
4 Different types of business organisations
Dr. Bognár Rita
5 Innovation, Innovative businesses
Dr. Bognár Rita
6 Business Model Generation
Dr. Bognár Rita
7 Business plan
Dr. Bognár Rita
8 Business plan development
Dr. Bognár Rita
9 Intercultural business communication
Dr. Bognár Rita
10 Basics of Marketing in healthcare business
Dr. Bognár Rita
11 Production
Dr. Bognár Rita
12 Product and process management
Dr. Bognár Rita
13 Quality management
Dr. Bognár Rita
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14 Time planning, Time management
Dr. Bognár Rita
15 Human resource management
Dr. Bognár Rita
16 Team building, Team work
Dr. Bognár Rita
17 Strategic management
Dr. Bognár Rita
18 Risk management
Dr. Bognár Rita
19 Healthcare finance
Dr. Bognár Rita
20 Introduction to accounting and financial management
Dr. Bognár Rita
21 Sustainable healthcare
Dr. Bognár Rita
22 Presenation methods and techniques
Dr. Bognár Rita
23 Administration, Documentation, Reports
Dr. Bognár Rita
24 Summary for written test
Dr. Bognár Rita
Practices
Seminars
Exam topics/questions
Neptun
Participants
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OPE-TG4-T STUDENT PROJECT RESEARCH FOR STUDENTS OF PHARMACEUTIST PROGRAMME 4
Course director: DR. GYÖRGYI HORVÁTH, associate professor
Department of Pharmacognosy gyorgyi.horvath@aok.pte.hu
2 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ both semesters ▪ recommended semester: 6
Number of hours/semester: 0 lectures + 24 practices + 0 seminars = total of 24 hours
Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPE-TG3-T completed
Topic
The course aims at promoting of students to make student research projects on the field of pharmaceutical sciences. Furthermore, we
wish to give individual possibilities of students to perform experiments in the different pharmaceutical institutes involved into Students’
Research Society.
Conditions for acceptance of the semester
The continuous student’s work is recommended. The continuous enrollment of consecutive courses can be stopped and continued in
further semesters.
The prerequisite of this course (TDK 4): registration of the student in the database of Students’ Research Society and the fulfillment of
the Student Project Research for Students of Pharmaceutist Programme 3 course.
Mid-term exams
- Introduction of conference abstract or conference manuscript (student is co-author) for the course supervisor at the end of 13th week of
the semester.
- Introduction of an article published in a national and/or international journal (student is co-author). It must be sent to the course
supervisor at the end of 13th week of the semester.
- Oral presentation at the Students’ Research Conference.
- Dean’s thesis
- Among the four conditions, one of them should be made at least.
Making up for missed classes
There is no possibility.
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
ScienceDirect database
Lectures
Practices
1-24 Research.
Seminars
Exam topics/questions
Not applicable.
Participants
Dr. Horváth Györgyi (GDLTCH)
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OPE-GFK-T PHYSICO-CHEMICAL BASES OF DRUG ACTION
Course director: DR. ZSUZSANNA ROZMER, assistant professor
Department of Pharmaceutical Chemistry zsuzsanna.rozmer@aok.pte.hu
2 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ spring semester ▪ recommended semester: 6
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 3 – 15 Prerequisites: none
Topic
The main objective of this course is to expand the knowledge in phyisico-chemical characterization of drug molecules and drug targets
for better understanding the drug action.
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
Written test.
Making up for missed classes
None.
Reading material
- Obligatory literature
- Literature developed by the Department
Zsuzsanna Rozmer, Pál Perjési: The physico-chemeical bases of drug actions. PTE, 2015.
- Notes
- Recommended literature
Lectures
1 Molecular bases of biological actions. Structural characteristics of drug targets.
Dr. Rozmer Zsuzsanna
2 Molecular bases of biological actions. Structural characteristics of drug targets.
Dr. Rozmer Zsuzsanna
3 Receptors as drug targets.
Dr. Rozmer Zsuzsanna
4 Receptors as drug targets.
Dr. Rozmer Zsuzsanna
5 Enzymes as drug targets.
Dr. Rozmer Zsuzsanna
6 Enzymes as drug targets.
Dr. Rozmer Zsuzsanna
7 Transporters and ion channels as drug targets.
Dr. Rozmer Zsuzsanna
8 Transporters and ion channels as drug targets.
Dr. Rozmer Zsuzsanna
9 Nucleic acids as drug targets.
Dr. Rozmer Zsuzsanna
10 Nucleic acids as drug targets.
Dr. Rozmer Zsuzsanna
11 Physicochemical properties of drug-drug target interactions. Intermolecular bonding.
Dr. Rozmer Zsuzsanna
12 Physicochemical properties of drug-drug target interactions. Intermolecular bonding.
Dr. Rozmer Zsuzsanna
13 Physicochemical properties of drug-drug target interactions. Affinity. Efficiency and selectivity.
Dr. Rozmer Zsuzsanna
14 Physicochemical properties of drug-drug target interactions. Affinity. Efficiency and selectivity.
Dr. Rozmer Zsuzsanna
15 Physicochemical properties of drug-drug target interactions. Stucture, stereochemistry.
Dr. Rozmer Zsuzsanna
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16 Physicochemical properties of drug-drug target interactions. Stucture, stereochemistry.
Dr. Rozmer Zsuzsanna
17 Physicochemical characteristics of drugs. Solubility.
Dr. Rozmer Zsuzsanna
18 Physicochemical characteristics of drugs. Solubility.
Dr. Rozmer Zsuzsanna
19 Physicochemical characteristics of drugs. Acid-base properties. Relevance and determination of the pKa value.
Dr. Rozmer Zsuzsanna
20 Physicochemical characteristics of drugs. Acid-base properties. Relevance and determination of the pKa value.
Dr. Rozmer Zsuzsanna
21 Physicochemical characteristics of drugs. Lipophilicity and partition coefficient. Determination of partition coefficients.
Dr. Rozmer Zsuzsanna
22 Physicochemical characteristics of drugs. Lipophilicity and partition coefficient. Determination of partition coefficients.
Dr. Rozmer Zsuzsanna
23 Physicochemical characteristics of drugs. Permeability. Experimental methods to determine permeability.
Dr. Rozmer Zsuzsanna
24 Physicochemical characteristics of drugs. Permeability. Experimental methods to determine permeability.
Dr. Rozmer Zsuzsanna
25 In silico ADME modelling. In vitro and in vivo tests.
Dr. Rozmer Zsuzsanna
26 In silico ADME modelling. In vitro and in vivo tests.
Dr. Rozmer Zsuzsanna
27 Physicochemical characteristics of drugs. Metabolic stability.
Dr. Rozmer Zsuzsanna
28 Physicochemical characteristics of drugs. Metabolic stability.
Dr. Rozmer Zsuzsanna
Practices
Seminars
Exam topics/questions
Topics of the written tests are set by the course director.
Participants
Dr. Rozmer Zsuzsanna (IIDYH7)
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OPE-FAO-T APPLIED HEALTH ECONOMICS
Course director: DR. LAJOS BOTZ, professor
Department of Pharmaceutics and University Pharmacy botz.lajos@pte.hu
2 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ spring semester ▪ recommended semester: 6
Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours
Course headcount limitations (min.-max.): 5 – 25 Prerequisites: OGG-GI1-T completed
Topic
Health economics applies economic thinking to the analysis of health and health care. This course provides students with an
understanding of the health economics principles and tools to analyse and address the challenges of limited resources faced by the health
sector.
By attending this course, students will
- learn about the key principles and methods of health economic evaluations and models
- know how to interpret the results of health economic evaluations
- gain insight into the perspective of decision makers
- better understand the crucial policy debates relating to health care.
The module is primarily aimed at medical, pharmacy and economic students who would like to improve their understanding of health
economics and research methods and at other students who are interested in the field.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Retake opportunity is possible following personal discussion.
Making up for missed classes
Retake opportunity is possible following personal discussion.
Reading material
- Obligatory literature
- Literature developed by the Department
All presentations can be downloaded from Neptun Meet Street.
- Notes
- Recommended literature
Lectures
1 Introduction to health economics 1.
Dr. Zemplényi Antal Tamás
2 Introduction to health economics 2.
Dr. Zemplényi Antal Tamás
3 Making decisions in healthcare 1.
Dr. Zemplényi Antal Tamás
4 Making decisions in healthcare 2.
Dr. Zemplényi Antal Tamás
5 Economic evaluation in healthcare (CEA, CUA, CBA) 1.
Dr. Zemplényi Antal Tamás
6 Economic evaluation in healthcare (CEA, CUA, CBA) 2.
Dr. Zemplényi Antal Tamás
7 Life tables and extrapolation 1.
Dr. Zemplényi Antal Tamás
8 Life tables and extrapolation 2.
Dr. Zemplényi Antal Tamás
9 Survival analysis 1.
Dr. Zemplényi Antal Tamás
10 Survival analysis 2.
Dr. Zemplényi Antal Tamás
11 Analysing health outcomes (QALY) 1.
Dr. Zemplényi Antal Tamás
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12 Analysing health outcomes (QALY) 2.
Dr. Zemplényi Antal Tamás
13 Measuring and valuing costs in healthcare 1.
Dr. Zemplényi Antal Tamás
14 Measuring and valuing costs in healthcare 2.
Dr. Zemplényi Antal Tamás
15 Health technology assessment - case study 1.
Dr. Zemplényi Antal Tamás
16 Health technology assessment - case study 2.
Dr. Zemplényi Antal Tamás
17 Decision analytic modelling: decision trees (practical exercise) 1.
Dr. Zemplényi Antal Tamás
18 Decision analytic modelling: decision trees (practical exercise) 2.
Dr. Zemplényi Antal Tamás
19 Decision analytic modelling: Markov models (practical exercise) 1.
Dr. Zemplényi Antal Tamás
20 Decision analytic modelling: Markov models (practical exercise) 2.
Dr. Zemplényi Antal Tamás
21 Interpreting cost-effectiveness results 1.
Dr. Zemplényi Antal Tamás
22 Interpreting cost-effectiveness results 2.
Dr. Zemplényi Antal Tamás
23 Market access of new pharmaceuticals - case study 1.
Dr. Zemplényi Antal Tamás
24 Market access of new pharmaceuticals - case study 2.
Dr. Zemplényi Antal Tamás
Practices
Seminars
Exam topics/questions
Based on the topics of the lectures.
Participants
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OPE-ASZ-T THE ANTIMICROBIAL DRUGS AND THEIR CLINICAL USE
Course director: DR. BÉLA KOCSIS, associate professor
Department of Medical Microbiology and Immunology kocsis.bela@pte.hu
2 credit ▪ midsemester grade ▪ Elective subject for the Medical-biological module ▪ spring semester ▪ recommended semester: 6
Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours
Course headcount limitations (min.-max.): 5 – 100 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
The aim of these lectures is to give a reliable and detailed knowledge about the antimicrobial drugs and their clinical use; to give ideas
how to choose the proper drug for the prophylaxis and therapy of infectious diseases
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
In the first 2 weeks of the exam period we give three times possibilities to write tests
Making up for missed classes
None
Reading material
- Obligatory literature
Jawetz et al.: Medical Microbiology
- Literature developed by the Department
- Notes
- Recommended literature
Lectures
1 Introduction, historical data, basic definitions
Dr. Kocsis Béla
2 Characterisation of antimicrobial drugs, chemical structure, their targets
Dr. Kocsis Béla
3 Characterisation of antimicrobial drugs, sensitivity and resistance
Dr. Kocsis Béla
4 Pharmacokinetics and pharmacodynamics of anti-infective drugs
Dr. Kocsis Béla
5 The antibiotic prophylaxis.
Dr. Kocsis Béla
6 The empiric antimicrobial therapy
Dr. Kocsis Béla
7 The antimicrobial therapy based on microbiologic result
Dr. Kocsis Béla
8 The choice of best antimicrobial drug
Dr. Kocsis Béla
9 The reasons of an unsuccessful antimicrobial therapy
Dr. Kocsis Béla
10 The antimicrobial drugs in details. The inhibitors of the cell wall biosynthesis Beta-lactams Penicillins
Dr. Kocsis Béla
11 Cephalosporins, carbapenems, monobactams, glicopeptides
Dr. Kocsis Béla
12 The inhibitors of the protein biosynthesis Aminoglicosides
Dr. Kocsis Béla
13 Tetracyclines Chloramphenicol Macrolides
Dr. Kocsis Béla
14 The inhibitors of the nucleic acid biosynthesis Rifampins Sulfonamides
Dr. Kocsis Béla
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15 Kinolons Fluorokinolons
Dr. Kocsis Béla
16 The antimycotic drugs
Dr. Kocsis Béla
17 The antiviral drugs HIV - AIDS
Dr. Kocsis Béla
18 The antiparasitic therapy. The chemoprophylaxis of malaria
Dr. Kocsis Béla
19 The antimicrobial therapy of respiratory and urinary tract infections
Dr. Kocsis Béla
20 Cardiovascular and wound infections, sepsis
Dr. Kocsis Béla
21 Central nervous system, abdominal and enteric infections
Dr. Kocsis Béla
22 Antimicrobial therapy of patients under immunosuppression, pregnancy....
Dr. Kocsis Béla
23 The pharmacological aspects of antimicrobial therapy
Dr. Kocsis Béla
24 The future of antimicrobial therapy
Dr. Kocsis Béla
Practices
Seminars
Exam topics/questions
None
Participants
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OPE-KPR-T CHEMOPREVENTION
Course director: DR. TÍMEA VARJAS, assistant professor
Department of Public Health Medicine vtimi_68@yahoo.com
1 credit ▪ midsemester grade ▪ Elective subject for the Medical-biological module ▪ spring semester ▪ recommended semester: 6
Number of hours/semester: 12 lectures + 0 practices + 0 seminars = total of 12 hours
Course headcount limitations (min.-max.): 1 – 20 Prerequisites: OPO-G2B-T completed
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
Chemoprevention is the administration of natural or (semi)synthetic agents to prevent, inhibit, or delay the progression of chronic
diseases. The focus is on cancer chemoprevention.
The way from a potent agent to a chemopreventive strategy will also be discussed.
Involving (chemo)preventive interventions in every-day practice could spare valuable life years.
Conditions for acceptance of the semester
Absences should not exceed 15% of lectures and practicals (2x45 min). Otherwise signature of grade book is denied.
Examination: test
Mid-term exams
Examination: test
Making up for missed classes
based on individual consideration
Reading material
- Obligatory literature
- Literature developed by the Department
PPT-presentations (Neptun)
- Notes
- Recommended literature
Lectures
1 Introduction - Chemoprevention as a preventive strategy
Dr. Szabó István
2 Introduction - Chemoprevention as a preventive strategy
Dr. Szabó István
3 Finding evidence
Dr. Szabó István
4 Finding evidence
Dr. Szabó István
5 Interventing chronic diseases
Dr. Szabó István
6 Interventing chronic diseases
Dr. Szabó István
7 Chemopreventive strategies - antioxidants
Dr. Szabó István
8 Actualities of antioxidants
Dr. Szabó István
9 Natural chemopreventive agents
Dr. Szabó István
10 Natural chemopreventive agents
Dr. Szabó István
11 Chemopreventive dietary factors
Dr. Szabó István
12 Chemopreventive dietary factors
Dr. Szabó István
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Practices
Seminars
Exam topics/questions
Neptun
Participants
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OPF-TS2-T CALCULATIONS IN PHARMACEUTICAL TECHNOLOGY 2
Course director: DR. SZILÁRD PÁL, assistant professor
Institute of Pharmaceutical Technology and Biopharmacy szilard.pal@aok.pte.hu
1 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 6
Number of hours/semester: 0 lectures + 0 practices + 12 seminars = total of 12 hours
Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPG-C2E-T parallel + OPG-C1E-T completed
Topic
Aim of the course is to deepen the knowledge of calculations needed for Pharmaceutical Technology 2 practice (dose checking,
prescription reading and understanding) by solving and practicing several examples together with the course leader.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Participation on the seminars - accepted work reports - accepted written assessments Students have to write an end-semester assessment
from the lectures at acceptance level of 60%.
Making up for missed classes
Students must fulfil requirements determined by the Code of Studies and Examinations. Student has to make up the missed lectures and
do work reports.
Reading material
- Obligatory literature
- Literature developed by the Department
Seminar notes.
- Notes
- Recommended literature
European Pharmacopoeia
Formulae Normales VII. (FoNo VII.)
James Swarbrick: Encyclopedia of Pharmaceutical Technology, Informa Healthcare, New York, London
Gilbert S. Banker, Christopher T. Rhodes: Modern Pharmaceutics, Marcel Dekker Inc., New York- Basel
Chris Langley, Dawn Belcher: Pharmaceutical Compounding and Dispensing, Pharmaceutical Press
Attila Dévay: The Theory and Practice of Pharmaceutical Technology, electronic book, PTE-Pécs
Attila Dévay: Investigation of Pharmaceutical Preparations, electronic book, PTE-Pécs
Lectures
Practices
Seminars
1 Introduction to calculations of disperse systems
2 Calculations related to HLB value
3 Dose checking in emulsions
4 Dose checking in suspensions
5 Calculations related to semi-solid dosage forms
6 Introduction to calculations related to suppositories (calibration value and displacement factor)
7 Calculations of divided form of prescribing suppositories
8 Calculations of dispensed form of prescribing suppositories
9 Dose checking of suppositories 1.
10 Dose checking of suppositories 2.
11 Dose checking of divided and undivided powders
12 Test
Exam topics/questions
Students can get the test topics in the institute or download the from website of the institute.
Participants
Ámanné Dr. Takácsi-Nagy Anna (SEGAOR), Dr. Kása Péter (ISWPRM), Dr. Pál Szilárd (FYF5E9)
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OPF-DTS-T THE ROLE OF DRUG TRANSPORTERS
Course director: DR. LUCA JÁROMI, assistant professor
Department of Pharmaceutical Biotechnology jaromi.luca@pte.hu
2 credit ▪ midsemester grade ▪ Optional subject ▪ both semesters ▪ recommended semester: 6
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 15 Prerequisites: OPG-R1E-T completed
Topic
Understanding the clinical importance, role and molecular procedures of interindividual variability in drug response is a critical area of
drug development and clinical pharmacotherapy.The genetic polymorphisms in drug-metabolizing enzymes, receptors, transporters and
other drug targets may have a crucial role in the background of this phenomenon, that can lead to the interindividual differences in
molecular ways, efficacy, as well as toxicity as a response to numerous clinical treatment. Cancer is the leading cause of mortality and
morbidity worldwide. The greatest obstacle of the successful treatment is the development of multidrug resistance (MDR) against
chemotherapy. During the past two decades, the act of carrier-mediated transport in defining the pharamcokinetics of drugs has become
progressively evident with the discovery of genetic polymorphisms that influence expression, localization, and/or function of a given
drug transporter. The aim of the course is to present the drug transporters and their genetic and pharmacogenetic background, to explain
their role in drug metabolism, especially focusing on different drug transporter families and on interactions of protein - drug - transporters.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Félév végén vizsga, vizsgaidőszakban pótvizsga lehetőségek
Making up for missed classes
Nincs, mert csak előadásokból áll a kurzus.
Reading material
- Obligatory literature
- Literature developed by the Department
PPT-bemutatók az előadások során.
- Notes
- Recommended literature
1.) Yuichi Sugiyama - Bente Steffansen: Transporters in Drug Development Discovery, Optimization,
Clinical Study and Regulation, ISSN 2210-7371 ISSN 2210-738X (electronic), ISBN 978-1-4614-8228-4 ISBN 978-1-4614-8229-1
(eBook), DOI 10.1007/978-1-4614-8229-1, Springer New York Heidelberg Dordrecht London
Library of Congress Control Number: 2013947789
2.) Toshihisa Ishikawa, Richard B. Kim: Pharmacogenomics of Human Drug Transporters, ISBN 978-0-470-92794-6
3.) Russ. B. Altman, David Flockhart, David B. Goldstein: Pharmacogenetics and Pharmacogenomics, ISBN 978-0-521-88537-9
Lectures
1 Introduction to world of drug transporters
Dr. Járomi Luca
2 General characteristics of drug transporters
Dr. Járomi Luca
3 Terms definition of drug transporters
Dr. Járomi Luca
4 Genetic role of drug transporters
Dr. Járomi Luca
5 Pharmacogenetic characteristics of drug transporters
Dr. Járomi Luca
6 Basics in phamacokinetics: definition of absorption, distribution, metabolism, and excretion (ADME)
Dr. Járomi Luca
7 Explanation of absorption, distribution, metabolism, and excretion (ADME)
Dr. Járomi Luca
8 Membrane transporters in ADME I.
Dr. Járomi Luca
9 Membrane transporters in ADME II.
Dr. Járomi Luca
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10 ADME pharmacogenomics in drug development I.
Dr. Járomi Luca
11 ADME pharmacogenomics in drug development II.
Dr. Járomi Luca
12 The role of transporters in drug development: regulatory science perspectives from the FDA
Dr. Járomi Luca
13 Industrial evaluation of drug transporters in ADME
Dr. Járomi Luca
14 The pharmacogenomics of membrane transporters I.
Dr. Járomi Luca
15 The pharmacogenomics of membrane transporters II.
Dr. Járomi Luca
16 Nucleoside transporters family
Dr. Járomi Luca
17 General characteristics of ABC-transporter family
Dr. Járomi Luca
18 Most relevant ones: ABC-transporters
Dr. Járomi Luca
19 P-glycoprotein (MDR1/ABCB1)
Dr. Járomi Luca
20 ABCG2
Dr. Járomi Luca
21 Cancer: exsorptive transporters (ABC) expressed on transformed cells
Dr. Járomi Luca
22 Proton-coupled nutrient transporters affect ADME properties
Dr. Járomi Luca
23 In vitro characterization of interactions with drug transporting proteins
Dr. Járomi Luca
24 In vivo characterization of interactions on transporters
Dr. Járomi Luca
25 Indication specific transporter studies
Dr. Járomi Luca
26 Future perspectives
Dr. Járomi Luca
27 Conclusions and outlook, summary
Dr. Járomi Luca
28 Exam
Dr. Járomi Luca
Practices
Seminars
Exam topics/questions
Introduction to world of drug transporters
General characteristics of drug transporters
Terms definition of drug transporters
Genetic role of drug transporters
Pharmacogenetic characteristics of drug transporters
Basics in phamacokinetics: definition of absorption, distribution, metabolism, and excretion (ADME)
Explanation of absorption, distribution, metabolism, and excretion (ADME)
Membrane transporters in ADME I.
Membrane transporters in ADME II.
ADME pharmacogenomics in drug development I.
ADME pharmacogenomics in drug development II.
The role of transporters in drug development: regulatory science perspectives from the FDA
Industrial evaluation of drug transporters in ADME
The pharmacogenomics of membrane transporters I.
The pharmacogenomics of membrane transporters II.
Nucleoside transporters family
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General characteristics of ABC-transporter family
Most relevant ones: ABC-transporters
P-glycoprotein (MDR1/ABCB1)
ABCG2
Cancer: exsorptive transporters (ABC) expressed on transformed cells
Proton-coupled nutrient transporters affect ADME properties
In vitro characterization of interactions with drug transporting proteins
In vivo characterization of interactions on transporters
Indication specific transporter studies
Future perspectives
Participants
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OPF-EXT-T EXTRACTION AND CHROMATOGRAPHIC TECHNIQUES IN MEDICINAL PLANT ANALYSIS
Course director: DR. TÍMEA BENCSIK, assistant professor
Department of Pharmacognosy timea.bencsik@aok.pte.hu
2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 6
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 20 Prerequisites: OPA-M1E-T completed
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
With the increasing demand for herbal medicinal products, nutraceuticals, and natural products for health care all over the world,
medicinal plant extract manufacturers and essential oil producers have started using the most appropriate extraction and chromatographic
technologies in order to produce and standardize extracts and essential oils of defined quality. The aim of this course is to introduce the
most important extraction methods and chromatographic techniques used in the research of medicinal plants. Students should be able to
apply the acquired knowledge in their medical or pharmaceutical practice.
Task: To introduce state-of-the-art extraction techniques (maceration, infusion, digestion, decoction, percolation, Soxhlet, ultrasound
extraction, supercritical fluid extraction, water and steam distillation, enfleurage, expression) and chromatographic analyses (column
chromatography, thin layer chromatography, high pressure liquid chromatography) of medicinal plants and their role in the production
of herbal medicines. Some applications, relating to different classes of substances, are presented to demonstrate the versatility of various
chromatographic techniques.
Requirements: students have to know the most frequent extraction and analytical techniques used in medicinal and aromatic plant
research.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
One written exam during the semester, the acceptance level is 60%. One oral presentation by students.
Making up for missed classes
There is no possibility to make up for a missed lecture and practice.
Reading material
- Obligatory literature
- Literature developed by the Department
PowerPoint presentations prepared by lecturers.
- Notes
- Recommended literature
1. Handa S.S., Khanuja S.P.S., Longo G., Rakesh D.D.: Extraction Technologies for Medicinal and Aromatic Plants, International
Centre for Science and High Technology, Trieste, 2008
2. Reich E., Schibli A.: High-Performance Thin-Layer Chromatography for the Analysis of Medicinal Plants, Thieme, UK, 2007
3. Colegate S.M.: Bioactive Natural Products Detection Isolation and Structural Determination, CRC Press, 2008
4. Niessen W.M.A.: Liquid Chromatography - Mass Spectrometry, CRC Press, 2006
5. Nyiredy, Sz.: Planar Chromatography, Springer, Budapest, 2001.
6. Harris, DC.: Quantitative Chemical Analysis, WH. Freeman and Co., 7th edition, New York, 2007,
7. Schiedt K., Liaaen-Jensen S.: Isolation and Analysis, in Carotenoids Vol. 1A: Isolation and Analysis, Eds.: Britton G., Liaaen-
Jensen S., Pfander H., Birkhäuser Verlag, Basel, 1995.
Lectures
1 Introduction of the course requirements. An Overview of Extraction Techniques for Medicinal and Aromatic Plants.
Dr. Bencsik Tímea
1 Chromatographic seminar: TLC.
Dr. Benkő András Antal
2 Introduction of state-of-the-art extraction techniques: maceration, infusion, digestion, decoction, percolation, Soxhlet, ultrasound
extraction, supercritical fluid extraction, water and steam distillation, enfleurage, expression.
Dr. Bencsik Tímea
2 Chromatographic seminar: HPLC.
Dr. Bencsik Tímea
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3 Introduction to Analytical Separations.
Dr. Benkő András Antal
4 Techniques for the Purposes of Botanical Research.
Dr. Benkő András Antal
5 Planar Chromatography: TLC.
Dr. Benkő András Antal
6 Role of Different Procedures and Test Systems in the Knowledge of Herbal Substances.
Dr. Benkő András Antal
7 Column Chromatography Systems: GC.
Dr. Benkő András Antal
8 Column Chromatography Systems: HPLC.
Dr. Benkő András Antal
9 Detectors Used in Different Separation Techniques and their Role in Qualitative and Quantitative Analysis.
Dr. Benkő András Antal
10 Classification of Detectors Based on their Sensitivity and Selectivity.
Dr. Benkő András Antal
11 Role of thin layer chromatography (TLC) in detecting microbiological processes: TLC-Bioautography.
Dr. Horváth Györgyi
12 Antimicrobial activity of essential oils using TLC-Bioautography.
Dr. Horváth Györgyi
13 Isolation and identification of carotenoids from medicinal plants.
Dr. Molnár Péter
14 Role of column liquid chromatography (CLC) in carotenoid research.
Dr. Molnár Péter
15 Examination of honeys, sugars, polyphenols.
Dr. Farkas Ágnes
16 Examination of honeys, sugars, polyphenols.
Dr. Farkas Ágnes
17 Identification of specific metabolites in herbal products. Adulterated dietary supplements.
Dr. Bencsik Tímea
18 Identification of specific metabolites in herbal products with TLC.
Dr. Bencsik Tímea
19 Isolation and Identification of flavonoids in medicinal plants.
Dr. Papp Nóra
20 Isolation and Identification of flavonoids in medicinal plants.
Dr. Papp Nóra
21 Quality of herbal products; our experiences in the Department of Pharmacognosy.
Dr. Bencsik Tímea
22 Quality of herbal products; our experiences in the Department of Pharmacognosy.
Dr. Bencsik Tímea
23 Student’s lecture.
Dr. Bencsik Tímea
24 Student’s lecture.
Dr. Bencsik Tímea
25 Written test.
Dr. Bencsik Tímea
26 Written test.
Dr. Bencsik Tímea
Practices
Seminars
Exam topics/questions
The topics of the 1 written test are similar to the topics of the lectures.
Participants
Dr. Bencsik Tímea (MIVXFC), Dr. Benkő András Antal (VF70AV)
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OPF-KNH-T PSYCHOACTIVE PLANTS
Course director: DR. KAMILLA ÁCS, assistant professor
Department of Pharmacognosy kamilla.acs@aok.pte.hu
2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 6
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 25 Prerequisites: OPO-G2E-T completed
Topic
The course includes 28 lectures. The aim of the course is to present the most commonly used psychoactive plants and hallucionogens
around the world. The course gives a general overview about the botanical character and medicinal value of the most frequent plants and
fungi. In addition legal regulation, international guidelines for their control and the problem of addiction are also discussed.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Fulfillment of the final test (minimum 60%).
Making up for missed classes
Downloading of lectures in Neptun.
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
Ratsch C., Hofmann A.(2007): The Encyclopedia of Psychoactive Plants: Ethnopharmacology and Its Applications.
McKenna D. (2018): Ethnopharmacologic Search for Psychoactive Drugs (Vol. 1 & 2): 50 Years of Research.
Schultes R.E. (2001): Plants of the Gods: Their Sacred, Healing, and Hallucinogenic Powers.
Willis C.(2015): Hallucinogens: The Truth About Hallucinogenic Plants.
Meuninck J. (2014): Basic Illustrated Poisonous and Psychoactive Plants.
Lectures
1 Attitude of psychoactive drugs in Hungary and Europe.
Dr. Ács Kamilla
2 Classification of psychoactive drugs: psychedelics, dissociatives and deliriants. Drug or medication?
Dr. Ács Kamilla
3 Opium and opiates around the world I.: Middle East, Western-, Middle- and South Asia
Dr. Ács Kamilla
4 Opium and opiates around the world II.: Southeast Asia, Europe, America
Dr. Ács Kamilla
5 Poppy seed (Papaver somniferum): legal use
Dr. Ács Kamilla
6 Poppy seed (Papaver somniferum): illegal use
Dr. Ács Kamilla
7 History of international audit of psychoactive drugs
Dr. Molnár Béla
8 International guidelines for the control of psychoactive substances
Dr. Molnár Béla
9 Synthetic opioids
Dr. Benkő András Antal
10 Detection of synthetic and plant originated hallucinogens. Analytics of psychoactive agents.
Dr. Benkő András Antal
11 Hallucinogenic plants I.: Solanaceae species
Dr. Ács Kamilla
12 Hallucinogenic plants II.: Ergot
Dr. Ács Kamilla
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13 Hallucinogenic plants III.: Plants from Asia
Dr. Ács Kamilla
14 Hallucinogenic plants IV.: Plants from South-America
Dr. Ács Kamilla
15 Hallucinogenic fungi
Dr. Ács Kamilla
16 Medicinal use of psychoactive plants I.: Erythroxylum coca
Dr. Ács Kamilla
17 Medicinal use of psychoactive plants II.: Catha edulis I.
Dr. Ács Kamilla
18 Medicinal use of psychoactive plants II.: Catha edulis II.
Dr. Ács Kamilla
19 Medicinal use of psychoactive plants III.: Ephedraceae I.
Dr. Ács Kamilla
20 Medicinal use of psychoactive plants III.: Ephedraceae II.
Dr. Ács Kamilla
21 Medicinal use of psychoactive plants IV: Cannabis sativa indica I.
Dr. Ács Kamilla
22 Medicinal use of psychoactive plants IV: Cannabis sativa indica II.
Dr. Ács Kamilla
23 Legalization of psychoactive agents I.
Dr. Ács Kamilla
24 Illegal drugs in criminal investigations.
Dr. Ács Kamilla
25 Drug abuse and addiction I.
Dr. Ács Kamilla
26 Drug abuse and addiction II.
Dr. Ács Kamilla
27 Exam
Dr. Ács Kamilla
28 Exam
Dr. Ács Kamilla
Practices
Seminars
Exam topics/questions
Topics include the lectures of the semester.
Participants
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OPF-NSG-T PLANT PRODUCTS IN THE PHARMACEUTICAL PRACTICE
Course director: DR. GYÖRGYI HORVÁTH, associate professor
Department of Pharmacognosy gyorgyi.horvath@aok.pte.hu
2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 6
Number of hours/semester: 20 lectures + 8 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 15
Prerequisites: OPO-G1E-T completed + OPO-G2E-T completed + OPG-O1E-T completed
Topic
Students will be familiar with the results of the latest studies on medicinal plants used in the prevention and treatment of diseases, and
the availability of authorized preparations and their use in modern medicine and health care, with their pharmacobotanical and
pharmacognosic knowledge. They should be able to make herbal preparations based on their knowledge.
Task: To present the active ingredient, medicinal use of medicinal herbs and preparations used in healing, to present the latest results of
phytotherapy research. Preparing tea blends and externally usable preparations in the practice sessions.
Requirement: Students should be able to apply their acquired knowledge to the highest possible level in their profession.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
During the semester, writing of one test at an acceptable level (min. 60%) is mandatory. In case of failed result, one possibility to repeat
is possible. Taking one student lecture is mandatory.
Making up for missed classes
No replacement is possible.
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
1. Aronson, JK.: Meyler’s Side Effects of Herbal Medicines, Elsevier, Oxford 2009
2. ESCOP Monographs, 2nd edition, Thieme, United Kingdom 2003
Lectures
1 Introduction. Plants on the market and their role in today’s medicine and pharmacy.
Dr. Horváth Györgyi
2 Availability of medicinal plant products on the Internet: dangers, challenges.
Dr. Horváth Györgyi
3 Herbs and products acting on the central nervous system.
Dr. Horváth Györgyi
4 Herbs and products acting on the central nervous system.
Dr. Horváth Györgyi
5 Herbs and products acting on heart and vascular system.
Dr. Horváth Györgyi
6 Herbs and products acting on heart and vascular system.
Dr. Horváth Györgyi
7 Herbs and products acting on respiratory tract.
Dr. Horváth Györgyi
8 Herbs and products acting on respiratory system.
Dr. Horváth Györgyi
9 Herbs and products acting on gastrointestinal tract.
Dr. Horváth Györgyi
10 Herbs and products acting on gastrointestinal tract.
Dr. Horváth Györgyi
11 Herbs and products acting on urinary tract.
Dr. Horváth Györgyi
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12 Herbs and products acting on urinary tract.
Dr. Horváth Györgyi
13 Herbal remedies for gynecological complaints.
Dr. Horváth Györgyi
14 Adaptogens.
Dr. Horváth Györgyi
15 Herbal remedies for dermatological diseases.
Dr. Horváth Györgyi
16 Herbal remedies for dermatological diseases.
Dr. Horváth Györgyi
17 Herbs and remedies for treating pain.
Dr. Horváth Györgyi
18 Herbs and products for treating pain.
Dr. Horváth Györgyi
19 Enhancing the body’s resistance (plant immunomodulators).
Dr. Horváth Györgyi
20 Students’s lecture. Written test.
Dr. Horváth Györgyi
Practices
1 Location of herbal remedies in today’s pharmaceuticals I: Preparation of herbal product.
2 Location of herbal remedies in today’s pharmaceuticals I: Preparation of herbal product.
3 Location of herbal remedies in today’s pharmaceuticals II: Evaluation of herbal product.
4 Location of herbal remedies in today’s pharmaceuticals II: Evaluation of herbal product.
5 Praparation of herbal tea.
6 Macroscopic and organoleptic examination of herbal tea preparation.
7 Preparation of product containing essential oils.
8 Checking the quality of herbal substances by chromatography: TLC.
Seminars
Exam topics/questions
The topics of the written test is the same with the lectures.
Participants
Dr. Horváth Györgyi (GDLTCH)
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OPF-PNT-T PHARMACEUTICAL NANOTECHNOLOGY
Course director: DR. ALEKSANDAR SECENJI, senior research fellow
Institute of Pharmaceutical Technology and Biopharmacy szealex@gamma.ttk.pte.hu
2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 6
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 5 – 50 Prerequisites: OPG-C1E-T completed
Topic
Nanotechnology is a multidisciplinary discipline, which is the approach of the production of materials, structures, and systems, in which
the material is handled and produced in nanometers i.e. in a billionth of a meter. Pharmaceutical nanotechnology is the application of
nanotechnology in the pharmaceutical industry in life and health sciences and is base for the development of nanostructured modern drug
delivery systems for therapeutic purposes as well as advanced diagnostic biosensors dealing with early detection of diseases
The aim of the course is to provide a comprehensive picture of the application of nanotechnology in drug development and
pharmaceuticals. A brief introduction to the history, role, and impact of nanotechnology on state-of-the-art technologies. The properties
of specific physicochemical properties of nanomaterials can be explained by the well-known thermodynamic principles. Because of the
small size, the surface and the quantum effects play a prominent role, the theoretical basis of which is presented. Hereinafter, the
classification of nanoscale medicines and their detailed presentation will be presented.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
1 written test
Making up for missed classes
not needed
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
1. Nanotechnology in Drug Delivery, Melgardt M. de Villiers, Pornanong Aramwit, Glen S. Kwon, Springer, DOI: 10.1007/978-
0-387-77667-5
2. Pharmaceutical Nanotechnology: Fundamentals and Practical Applications, Costas Demetzos, ADIS, DOI 10.1007/978-981-
10-0791-0
3. Pharmaceutical Nanotechnology: Innovation and Production, Jean Cornier, Andrew Owen, Arno Kwade, and Marcel Van de
Voorde, WILEY-VCH, Print ISBN: 978-3-527-34054-5, ePDF ISBN: 978-3-527-80067-4
Lectures
1 Introduction to Nanotechnology
Dr. Secenji Aleksandar
2 Introduction to Nanotechnology
Dr. Secenji Aleksandar
3 Theoretical basics of nanotechnology
Dr. Secenji Aleksandar
4 Theoretical basics of nanotechnology
Dr. Secenji Aleksandar
5 Drug nanocarriers classification
Dr. Secenji Aleksandar
6 Drug nanocarriers classification
Dr. Secenji Aleksandar
7 Inorganic nanostructures
Dr. Secenji Aleksandar
8 Inorganic nanostructures
Dr. Secenji Aleksandar
9 Organic nanostructures
Dr. Secenji Aleksandar
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10 Organic nanostructures
Dr. Secenji Aleksandar
11 Pharmaceutical nanocrystals
Dr. Secenji Aleksandar
12 Pharmaceutical nanocrystals
Dr. Secenji Aleksandar
13 Matrix Systems
Dr. Secenji Aleksandar
14 Matrix Systems
Dr. Secenji Aleksandar
15 Porous systems
Dr. Secenji Aleksandar
16 Porous systems
Dr. Secenji Aleksandar
17 Binding, filling, trapping and releasing the drug from nanostructures
Dr. Secenji Aleksandar
18 Binding, filling, trapping and releasing the drug from nanostructures
Dr. Secenji Aleksandar
19 Hydrophobic drugs
Dr. Secenji Aleksandar
20 Hydrophobic drug
Dr. Secenji Aleksandar
21 Hydrophilic drugs
Dr. Secenji Aleksandar
22 Hydrophilic drugs
Dr. Secenji Aleksandar
23 Makromolecular drug carriers
Dr. Secenji Aleksandar
24 Makromolecular drug carriers
Dr. Secenji Aleksandar
25 Vesicular drug delivery systems
Dr. Secenji Aleksandar
26 Vesicular drug delivery systems
Dr. Secenji Aleksandar
27 Nano Emulsions, Pickering Emulsions
Dr. Secenji Aleksandar
28 Nano Emulsions Pickering Emulsions
Dr. Secenji Aleksandar
Practices
Seminars
Exam topics/questions
1. Introduction to Nanotechnology
2. Theoretical basics of nanotechnology
3. Drug nanocarriers classification
4. Inorganic nanostructures
5. Organic nanostructures
6. Pharmaceutical nanocrystals
7. Matrix Systems
8. Porous systems
9. Binding, filling, trapping and releasing the drug from nanostructures
10. Hydrophobic drug
11. Hydrophilic drugs
12. Makromolecular drug carriers
13. Vesicular drug delivery systems
14. Nano Emulsions Pickering Emulsions
Participants
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OPE-FMA-T DATA ANALYSIS 1
Course director: DR. LÁSZLÓ PÓTÓ, associate professor
Institute of Bioanalysis laszlo.poto@aok.pte.hu
1 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ autumn semester ▪ recommended semester: 7
Number of hours/semester: 6 lectures + 6 practices + 0 seminars = total of 12 hours
Course headcount limitations (min.-max.): 1 – 12 Prerequisites: none
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
The goal of this course is to help students to prepare for thesis writing or making their own student research project. It covers mainly two
fields of that: read and interpret scientific papers and prepare an own study plan. Shortly to say: How to prepare for your own study
project.
Block One: The medical papers are likely the most important source to improve your present knowledge as a student and as an
MD. Most of these ‘original papers’ are based on carefully planned data collection and evaluation applying a wide array of statistical
methods. It is essential to be familiar with this methodology so to understand these papers. But you may learn these steps and methods
from the papers since all are based on the rules of designing scientific research projects. From a paper you may extract the principles as
well as you can follow immediately the realization. It is an excellent way to learn the methodology. You may even learn from the errors.
Block Two: Apply all these for your own research: make a study plan. It should include your study goal the extent and way of
your data collection the preliminary data processing the way of data analysis and the way of conclusion making.
Based on this outline you will prepare your own study design on your own student”s research work or on your thesis job. If you have no
such project at the moment you may construct an own “;sample study plan” that can be a working model for your future thesis work.
You will have all help to find your own project and complete the plan in the practice if you need. All of your personal design elements
will be discussed and improved by a class discussion.
The practical realization of your study will be supported by the Data analysis 2 course.
Conditions for acceptance of the semester
Maximum 1 lesson absence.
Mid-term exams
Prepare and submit your own study plan step-by-step and present sortly weekly to the group - based on your active participation.
Making up for missed classes
One extra class
Reading material
- Obligatory literature
1-3 medical papers brought by each student (from library, from your department or from the tutor of your thesis).
- Literature developed by the Department
Other supporting materials supplied by the tutor of the classes.
- Notes
- Recommended literature
Any statistical books on study design and data analysis.
Lectures
1 Introduction. Find a paper to process. Find your own study.
Dr. Pótó László
2 The goal of your study - based on a demo paper
Dr. Pótó László
3 The main- and ‘sub-’hypotheses of the study.
Dr. Pótó László
4 Finding your sample frame - based on your hypotheses.
Dr. Pótó László
5 The research design and the methods of the data collection. How many data should be collected?
Dr. Pótó László
6 Creating the plan of the data analysis. The complete study plan.
Dr. Pótó László
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Practices
1 Introduction. Overview of some sample papers.
Dr. Pótó László
2 The goal of your study - processing a few papers brought and presented by students.
Dr. Pótó László
3 Setting the study hypotheses. Further analysis of the papers.
Dr. Pótó László
4 Which data should you collect and how to do that.
Dr. Pótó László
5 Finalize the plan of your data collection. Make a plan of the data processing.
Dr. Pótó László
6 Create, present and discuss of your study plan.
Dr. Pótó László
Seminars
Exam topics/questions
Preparation of the study plan
Participants
Dr. Pótó László (FIO4UU)
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OPE-FM2-T DATA ANALYSIS 2
Course director: DR. LÁSZLÓ PÓTÓ, associate professor
Institute of Bioanalysis laszlo.poto@aok.pte.hu
1 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ autumn semester ▪ recommended semester: 7
Number of hours/semester: 6 lectures + 6 practices + 0 seminars = total of 12 hours
Course headcount limitations (min.-max.): 1 – 12 Prerequisites: OPE-FMA-T parallel
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
The goal of this course is to help students to prepare for thesis writing or making their own student research project. It covers two fields
of that job: the practice of data collection and prepare data for the analysis as well as the performing the analysis based on the preliminary
analysis plan. Shortly to say: How to perform the data collection and analysis of your own study project. (This course can be the
continuation of the “Data analysis 1” course however someone can complete these two courses on a reversed order as well. The main
reason of this flexibility is, that many students are asking for help when they have already had their data at hands (at least partially), and
this course is processing the steps from this point of the job. Even though, it is beneficial for the students doing this course first to
complete the Data analysis 1 course later. They can do it next year for example - so to understand the preliminary steps of a research
work: How to make a research plan?)
This course is also based on the medical papers. Students may pick the appropriate data collection methods and recognize the critical
points of this process based on the most fundamental papers of their own research field. They can learn from the most rewarded experts
on this way. From a paper you may extract the principles as well as you can follow immediately the realization. It is an excellent way to
learn the methodology. You may even learn from the errors.
The same way is followed for the data analysis and making conclusions. Every student will do his/her own data analysis based on their
own plan.
Students will have all help to the practical evaluation of their own data and making the right conclusion. The steps and results will be
discussed and improved by a class discussion.
Conditions for acceptance of the semester
Maximum 1 lesson absence.
Mid-term exams
Evaluate your data step by step and present it to the group weekly.
Making up for missed classes
One extra class
Reading material
- Obligatory literature
1-3 medical papers brought by each student (from library, from your department or from the tutor of your thesis).
- Literature developed by the Department
Supporting materials (papers, posters, research reports, ...) supplied by the tutor of the classes.
- Notes
- Recommended literature
Any statistical books.
Lectures
1 Introduction. Find a paper to process. Prepare or present your own data collection plan.
Dr. Pótó László
2 The realization of the data collection - examples are based on papers
Dr. Pótó László
3 The preliminary data preparations for the following statistical analysis.
Dr. Pótó László
4 Do your own statistical analysis 1-2: - select the right methods, - interpret the results.
Dr. Pótó László
5 Make your conclusion and share the results with the others.
Dr. Pótó László
6 Summary. Consolidation and evaluation of the results.
Dr. Pótó László
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Practices
1 Find a paper to process. Work on your own data collection plan.
Dr. Pótó László
2 Present the realization of the data collection - based on selected papers
Dr. Pótó László
3 Share your experiences on your preliminary data preparations - make corrections if needed.
Dr. Pótó László
4 Present your own statistical analysis - methods and results
Dr. Pótó László
5 Make your conclusion and share the results with the others.
Dr. Pótó László
6 Overview and summarize the results of the class.
Dr. Pótó László
Seminars
Exam topics/questions
Evaluate your data and submit your own results based on your active participation.
Participants
Dr. Pótó László (FIO4UU)
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OPE-T2F-T PHARMACEUTICAL BIOTECHNOLOGY AND ITS LINKS TO BIOPHARMACEUTICALS
Course director: DR. JUDIT ERZSÉBET PONGRÁCZ, professor
Department of Pharmaceutical Biotechnology pongracz.e.judit@pte.hu
3 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ autumn semester ▪ recommended semester: 7
Number of hours/semester: 28 lectures + 14 practices + 0 seminars = total of 42 hours
Course headcount limitations (min.-max.): 5 – 50 Prerequisites: none
Topic
The aim of this course is to introduce students to the science of pharmaceutical biotechnology and its links to biopharmaceuticals.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Writing test
Making up for missed classes
According to the Code of Studies and Examinations
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
Lecture notes, lecture materials available on MeetStreet
- Recommended literature
Lectures
1 Pharmaceuticals, biologics and biopharmaceuticals - link to Biotechnology. An introduction.
Dr. Kvell Krisztián
2 Protein structure and its importance of engineering biopharmaceuticals
Dr. Kvell Krisztián
3 Gene manipulation and recombinant DNA technology 1: Nucleic acid manipulation
Dr. Kvell Krisztián
4 Gene manipulation and recombinant DNA technology 2: Recombinant production of therapeutic proteins.
Dr. Kvell Krisztián
5 Gene manipulation and recombinant DNA technology 3: Nucleic acid manipulation.
Dr. Kvell Krisztián
6 Biotechnological methodology in drug development 1
Dr. Pongrácz Judit Erzsébet
7 Biotechnological methodology in drug development 2
Dr. Pongrácz Judit Erzsébet
8 Biotechnological methodology in drug development 3
Dr. Pongrácz Judit Erzsébet
9 Sources and upstream processing 1
Dr. Pongrácz Judit Erzsébet
10 Sources and upstream processing 2
Dr. Pongrácz Judit Erzsébet
11 Downstream processing 1
Dr. Járomi Luca
12 Downstream processing 2
Dr. Járomi Luca
13 Product analysis
Dr. Járomi Luca
14 The cytokines: the interferon family
Dr. Járomi Luca
15 Cytokines: Interleukin and tumor necrosis factor
Dr. Járomi Luca
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16 Growth factors
Dr. Pongrácz Judit Erzsébet
17 Therapeutic hormones
Dr. Pongrácz Judit Erzsébet
18 Recombinant blood proteins and therapeutic enzymes
Dr. Pongrácz Judit Erzsébet
19 Antibodies in diagnostics and therapy
Dr. Pongrácz Judit Erzsébet
20 Vaccines and adjuvants
Dr. Pongrácz Judit Erzsébet
21 Vaccine production
Dr. Pongrácz Judit Erzsébet
22 Nucleic acid-based therapeutics. Gene therapy.
Dr. Kvell Krisztián
23 Nucleic acid-based therapeutics. Recombinant viruses in cancer therapy.
Dr. Pongrácz Judit Erzsébet
24 Cell-based therapeutics
Dr. Kvell Krisztián
25 Test systems for toxicology
Dr. Járomi Luca
26 Test systems for efficacy
Dr. Járomi Luca
27 Nanotechnology
Dr. Pongrácz Judit Erzsébet
28 Legal aspects of healthcare-related Biotechnology
Dr. Pongrácz Judit Erzsébet
Practices
1 Principals of gene cloning - using the NCBI database
2 Cloning a specific gene - a practical approach 1
3 Cloning a specific gene - a practical approach 2
4 Cloning a specific gene - a practical approach 3
5 Culturing organisms for protein production
6 Culturing organisms for protein production
7 Selection and application of organisms for protein production
8 Protein purification for therapeutic application 1
9 Protein purification for therapeutic application 2
10 Technical approach for monoclonal antibody production 1
11 Technical approach for monoclonal antibody production 2
12 Testing toxicity using methodology of biotechnology
13 Efficacy testing using methodology of biotechnology
14 Nanotechnological methods
Seminars
Exam topics/questions
MeetStreet
Participants
Dr. Járomi Luca (FBC8DT), Dr. Kvell Krisztián (Y0GLOV)
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OPE-SHK-T DESIGN AND INDUSTRIAL MANUFACTURE OF MEDICINES
Course director: DR. SZILÁRD PÁL, assistant professor
Institute of Pharmaceutical Technology and Biopharmacy szilard.pal@aok.pte.hu
2 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ autumn semester ▪ recommended semester: 7
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPG-BFR-T completed + OPG-C2E-T completed
Topic
During the course, the process of the design of modified drug delivery systems is acquired by the students based on the theory and
practice of biopharmaceutical including examinations of dosage forms. The course consists of theoretical lectures and seminars.
Conditions for acceptance of the semester
- participation on the lectures
- accepted work reports
- accepted written assessments
Mid-term exams
Students have to write an end-semester assessment from the lectures at acceptance level of 60%.
Making up for missed classes
Students must fulfil requirements determined by the Code of Studies and Examinations. Student has make up for the missed lectures and
work reports.
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
Leon Shargel, A. B.C. Yu, Stamford: Applied Biopharmaceutics and Pharmacokinetics
Susanna Wu-Pong, Yon Rojanasakul: Biopharmaceutical Drug Design and Development, Humana Press
Gilbert S. Banker, Christopher T. Rhodes: Modern Pharmaceutics, Marcel Dekker Inc., New York- Basel
Michael J. Rathbone, Michael S. Roberts: Modified-Release Drug Delivery Technology, Informa Healthcare
Michael E. Aulton: The Design and Manufacture of Medicines, Churchill Livingstone
Lectures
1 Floating drug delivery, Targeted Drug Delivery Systems
Dr. Pál Szilárd
2 Floating drug delivery, Targeted Drug Delivery Systems
Dr. Pál Szilárd
3 Floating drug delivery, Targeted Drug Delivery Systems
Dr. Pál Szilárd
4 Floating drug delivery, Targeted Drug Delivery Systems
Dr. Pál Szilárd
5 Introduction of modified drug delivery
Dr. Kása Péter
6 Introduction of modified drug delivery
Dr. Kása Péter
7 Introduction of modified drug delivery
Dr. Kása Péter
8 Introduction of modified drug delivery
Dr. Kása Péter
9 Targeted Drug Delivery Systems
Dr. Secenji Aleksandar
10 Targeted Drug Delivery Systems
Dr. Secenji Aleksandar
11 Targeted Drug Delivery Systems
Dr. Pál Szilárd
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12 Targeted Drug Delivery Systems
Dr. Pál Szilárd
13 Pulsative Drug Delivery Systems
Dr. Pál Szilárd
14 Pulsative Drug Delivery Systems
Dr. Pál Szilárd
15 Pulsative Drug Delivery Systems
Dr. Pál Szilárd
16 Pulsative Drug Delivery Systems
Dr. Pál Szilárd
17 Dissolution, lecture and practice
Ámanné Dr. Takácsi-Nagy Anna
18 Dissolution, lecture and practice
Ámanné Dr. Takácsi-Nagy Anna
19 Dissolution, lecture and practice
Dr. Pál Szilárd
20 Dissolution, lecture and practice
Dr. Pál Szilárd
21 From molecule to the preparition
Dr. Kása Péter
22 From molecule to the preparition
Dr. Kása Péter
23 From molecule to the preparition
Dr. Pál Szilárd
24 From molecule to the preparition
Dr. Pál Szilárd
25 3D printing in pharmaceutical technology
Dr. Pál Szilárd
26 3D printing in pharmaceutical technology
Dr. Pál Szilárd
27 Assessment
Dr. Pál Szilárd
28 Assessment
Dr. Pál Szilárd
Practices
Seminars
Exam topics/questions
Students can get the test topics in the institute or download the from website of the institute.
Participants
Dr. Dévay Attila (BSX334), Dr. Pál Szilárd (FYF5E9)
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OPF-KIA-T ESSENTIAL OILS AND CLINICAL AROMATHERAPY
Course director: DR. GYÖRGYI HORVÁTH, associate professor
Department of Pharmacognosy gyorgyi.horvath@aok.pte.hu
2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 7
Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours
Course headcount limitations (min.-max.): 3 – 50 Prerequisites: OPG-O1E-T completed + OPG-O2E-T completed
Topic
Essential oils (EOs) are very interesting natural products and among other qualities they possess various biological properties. The term
biological comprises to all activities that these mixtures of volatile compounds (mainly mono- and sesquiterpenoids, phenylpropanoids,
etc.) exert on humans. EOs are used for their therapeutic action, for flavouring, in perfumery, or as starting materials for the synthesis of
other compounds. For therapeutic purposes they are administered as inhalations (e.g. eucalyptus oil), orally (e.g. peppermint oil) and
transdermally (e.g. rosmary oil). Oils with a high phenol content, for instance thyme and clove, have antiseptic properties, whereas others
are used as carrminatives. Oils showing antispasmodic activity, and much used in popular medicine, are those of melissa, peppermint,
chamomile, fennel, caraway and orange. Furthermore, in traditional medicine, EOs are also well-known for their analeptic, antimicrobial,
antinociceptive, antiphlogistic, antioxidative and sedative activities. All terpenoids easily enter the human body by oral absorption,
penetration through the skin, or inhalation very often leading to measurable blood concentrations. The aim of this course is to introduce
the most important medicinal plants containing essential oils and their medicinal role in the therapy and the clinical aromatherapy. We
would like to highlight their appropriate use, their profiles, but to call students’ attention to the cautions and contraindications of EOs, as
well.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Two written exams during the semester, acceptance of them from 60%.
Making up for missed classes
There is no possibility.
Reading material
- Obligatory literature
- Literature developed by the Department
PowerPoint presentations prepared by lecturers.
- Notes
- Recommended literature
1. Evans W.C.: Trease and Evans Pharmacognosy, Saunders, London, New York, 2000
2. Tisserand R., Balacs T.: Essential Oil Safety: A Guide for Health Care Professionals, Churchill Livingstone, 1995
3. Tisserand R., Young R: Essential Oil Safety: A Guide for Health Care Professionals, Second edition, Churchill Livingstone, 2013
Baser C.H, Buchbauer G.: Handbook of Essential Oils. Science, Technology and Application. CRC Press, Boca Raton, 2010
Lectures
1 Introduction of the course requirements. Definition of aromatherapy and clinical aromatherapy.
Dr. Horváth Györgyi
2 Advantages and disadvantages of the application of essential oils.
Dr. Horváth Györgyi
3 History of the use of essential oils.
Dr. Horváth Györgyi
4 Biological activities of essential oils.
Dr. Horváth Györgyi
5 Sources of essential oils.
Dr. Horváth Györgyi
6 Chemistry of essential oils. Chemical composition of essential oils.
Dr. Horváth Györgyi
7 Extraction techniques of essential oils: water-steam distillation, enfleurage, expression, supercritical fluid extraction. Gas
chromatographic analysis of essential oils.
Dr. Horváth Györgyi
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8 Extraction techniques of essential oils: water-steam distillation, enfleurage, expression, supercritical fluid extraction. Gas
chromatographic analysis of essential oils.
Dr. Horváth Györgyi
9 Drugs containing essential oils in the European Pharmacopoeia and in the ESCOP Monograph.
Dr. Horváth Györgyi
10 Quality of essential oils according to the official Pharmacopoeias.
Dr. Horváth Györgyi
11 External application of essential oils.
Dr. Horváth Györgyi
12 The most important base oils.
Dr. Horváth Györgyi
13 Physiological effects of essential oils. Metabolism of essential oil components in animal models and humans.
Dr. Horváth Györgyi
14 Contraindications.
Dr. Horváth Györgyi
15 Written test I
Dr. Horváth Györgyi
16 Written test I
Dr. Horváth Györgyi
17 Antimicrobial activity of essential oils. In vitro methods.
Dr. Horváth Györgyi
18 Antimicrobial activity of essential oils. In vivo methods.
Dr. Horváth Györgyi
19 Description of essential oils I: their main components and medicinal use. Peppermint oil, lemon oil, citronella oil, pine oil,
lavender oil.
Dr. Horváth Györgyi
20 Description of essential oils I: their main components and medicinal use. Peppermint oil, lemon oil, citronella oil, pine oil,
lavender oil.
Dr. Horváth Györgyi
21 Description of essential oils II: their main components and medicinal use. Clary sage oil, rosemary oil, tea tree oil, clove oil,
thyme oil, chamomile oil.
Dr. Horváth Györgyi
22 Description of essential oils II: their main components and medicinal use. Clary sage oil, rosemary oil, tea tree oil, clove oil,
thyme oil, chamomile oil.
Dr. Horváth Györgyi
23 Description of essential oils II.: their main components and medicinal use. Cinnamon oil, bitter and sweet orange oil, anise oil,
carraway oil, eucalyptus oil, sweet fennel oil, spearmint oil.
Dr. Horváth Györgyi
24 Description of essential oils II.: their main components and medicinal use. Cinnamon oil, bitter and sweet orange oil, anise oil,
carraway oil, eucalyptus oil, sweet fennel oil, spearmint oil.
Dr. Horváth Györgyi
25 Safety guidelines of essential oils.
Dr. Horváth Györgyi
26 Safety guidelines of essential oils.
Dr. Horváth Györgyi
27 Written test II
Dr. Horváth Györgyi
28 Written test II
Dr. Horváth Györgyi
Practices
Seminars
Exam topics/questions
There is no list. The questions of the written test is similar to the lecture topics.
Participants
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OPF-XES-T THE FATE OF DRUG
Course director: DR. ORSOLYA RIDEG, research associate professor
Department of Pharmaceutical Biotechnology ridegorsi@yahoo.com
1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 7
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OGG-R1E-T completed
Topic
By the end of the course, the students get an outlook on the history and basics of genetics and pharmacogenetics.They get an outlook on
the newest methodical aspects of genetic variants and enzyme function. By discussing certain clinical cases (mostly clinical cases from
the central nervous system, pulmonology, and hepatology) students get an outlook on the importance and complexity of the area.
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
One test at the end of the course.
Making up for missed classes
No option for supplement.
Reading material
- Obligatory literature
- Literature developed by the Department
Educational material in PDF
- Notes
- Recommended literature
Genetic Variation: Methods and Protocols; Barnes Michael R.; Springer
Concepts and tools in Pharmacogenomics - FDA
Principles of Pharmacogenetics and Pharmacogenomics; Rus B. Altman;Cambridge
Lectures
1 Basics on Genetics and Pharmacology, History of Pharmacogenetics
Dr. Rideg Orsolya
2 Basics on Genetics and Pharmacology, History of Pharmacogenetics
Dr. Rideg Orsolya
3 Fate of Drugs-CYP metabolization (classification, genetic background, function)
Dr. Rideg Orsolya
4 Fate of Drugs-CYP metabolization (classification, genetic background, function)
Dr. Rideg Orsolya
5 Expression and regulation of xenobiotic Metabolizing Cytochrome P450 Enzymes in the Liver
Dr. Rideg Orsolya
6 Expression and regulation of xenobiotic Metabolizing Cytochrome P450 Enzymes in the Liver (case study)
Dr. Rideg Orsolya
7 Expression and regulation of xenobiotic Metabolizing Cytochrome P450 Enzymes in the Central Nervus System
Dr. Rideg Orsolya
8 Expression and regulation of xenobiotic Metabolizing Cytochrome P450 Enzymes in the Central Nervus System (case study)
Dr. Rideg Orsolya
9 Expression and regulation of xenobiotic Metabolizing Cytochrome P450 Enzymes in the Lung
Dr. Rideg Orsolya
10 Expression and regulation of xenobiotic Metabolizing Cytochrome P450 Enzymes in the Lung (case study)
Dr. Rideg Orsolya
11 Role of CYP genepolymorphisms’ in neurological and cardiological diseases.
Dr. Rideg Orsolya
12 Methodical aspects of genetic variants
Dr. Rideg Orsolya
13 Methodical aspects of enzyme function.
Dr. Rideg Orsolya
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14 Test
Dr. Rideg Orsolya
Practices
Seminars
Exam topics/questions
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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OPE-DRO-T DRUG AND SUBSTANCE ABUSE
Course director: DR. ERIKA SÁNTICS-PINTÉR, professor
Department of Pharmacology and Pharmacotherapy erika.pinter@aok.pte.hu
1 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ spring semester ▪ recommended semester: 8
Number of hours/semester: 12 lectures + 0 practices + 0 seminars = total of 12 hours
Course headcount limitations (min.-max.): 5 – 30 Prerequisites: OPG-D1E-T completed
Topic
The course aimed to provide general terms of drug and substance abuse and present its physiological and biochemical background. We
are going to review systematically the most important pharmacological features of the drugs of abuse, the symptoms, dangers and possible
treatments of abuse. The drugs are discussed in the following sections: opioids, anxiolytics, sedatohypnotics, inhalants, alcohol,
psychomotor stimulants (amphetamin and derivates, cocain, coffein, nicotin), psychedelics and hallucinogens (LSD, mescalin,
phencyclidin), cannabis. After the discussion of pharmacology the participants can hear about the practical problems of drug abuse. At
the end of the course the students should present 5-10 minute ppt presentations from different abuse-related topics.
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
There is no possibility.
Making up for missed classes
There is no possibility.
Reading material
- Obligatory literature
- Literature developed by the Department
Uploaded on the Neptun
- Notes
- Recommended literature
Lectures
1 General terms of drug abuse, definition of dependence and tolerance
Sánticsné Dr. Pintér Erika
2 General terms of drug abuse, definition of dependence and tolerance
Sánticsné Dr. Pintér Erika
3 Opioid abuse
Dr. Horváth Ádám István
4 Abuse of anxiolytics and sedatohypnotics. Inhalants.
Dr. Horváth Ádám István
5 Alcohol abuse
Dr. Horváth Ádám István
6 Abuse of psychomotor stimulants
Dr. Horváth Ádám István
7 Psychedelics, hallucinogens, cannabis
Sánticsné Dr. Pintér Erika
8 Designer drugs
Sánticsné Dr. Pintér Erika
9 Practical problems of drug abuse
Dr. Szemelyácz János
10 Practical problems of drug abuse
Dr. Szemelyácz János
11 Presentations of students
Sánticsné Dr. Pintér Erika
12 Written exam
Sánticsné Dr. Pintér Erika
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Practices
Seminars
Exam topics/questions
1. General terms of drug abuse, definition of dependence and tolerance
2. Opioid abuse
3. Abuse of anxiolytics and sedatohypnotics. Inhalants.
4. Alcohol abuse
5. Abuse of psychomotor stimulants
6. Psychedelics, hallucinogens, cannabis
7. Designer drugs
Participants
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OPE-MGT-T PHARMACEUTICAL TECHNOLOGY OF MODIFIED DRUG RELEASE
Course director: DR. SZILÁRD PÁL, assistant professor
Institute of Pharmaceutical Technology and Biopharmacy szilard.pal@aok.pte.hu
1 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ spring semester ▪ recommended semester: 8
Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours
Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPG-C4E-T parallel
Topic
Students can get acquainted in details with modified drug delivery technologies and special industrial drug manufacture (3D printing,
manufacture of multi-layer tablets and osmotic preparations) and the importance of pharmaceutical excipients. Student will learn special
manufacturing technologies through the demonstration of dosage forms already available in the pharmaceutical therapy.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
During the end semester test 60 % should be reached.
Making up for missed classes
According to the Code of Studies and Examinations
Reading material
- Obligatory literature
- Literature developed by the Department
- Notes
- Recommended literature
James Swarbrick: Encyclopedia of Pharmaceutical Technology, Informa Healthcare, 2011
Lectures
1 Theory of modified drug release
Dr. Pál Szilárd
2 Importance of excipients, patents of excipient-compositions
Dr. Kása Péter
3 Immediate drug-release (OraSolv, DuraSolv, Zydis technology)
Dr. Pál Szilárd
4 Sustained drug-release: Multiparticulate dosage forms I. (sustained release pellets in practice)
Dr. Pál Szilárd
5 Multiparticulate dosage forms II. (MUPS technology)
Dr. Pál Szilárd
6 Matrix systems I. (hydrophilic matrices)
Dr. Pál Szilárd
7 Matrix systems II. (hydrophobic matrices)
Dr. Pál Szilárd
8 Osmotic technology (EOP, OROS, L-OROS, GITS)
Dr. Pál Szilárd
9 Geometry based drug-release (Geomatrix, Procise, Smartrix technology)
Dr. Kása Péter
10 Chronotherapeutic systems (Geoclock technology)
Dr. Pál Szilárd
11 3D printing in the field of modified drug delivery
Dr. Pál Szilárd
12 Site specific drug release (gastroretentive systems, colon-specific drug delivery)
Dr. Pál Szilárd
13 Halving of tablets, technology of halving-friendly tablets, concept of ,,ghost” tablets
Dr. Kása Péter
14 End-year test
Dr. Pál Szilárd
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Practices
Seminars
Exam topics/questions
http://gytk.pte.hu
Participants
Dr. Kása Péter (ISWPRM), Dr. Pál Szilárd (FYF5E9)
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OPE-FAJ-T PAIN AND ANALGESICS
Course director: DR. GÁBOR ISTVÁN PETHŐ, professor
Department of Pharmacology and Pharmacotherapy gabor.petho@aok.pte.hu
1 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ spring semester ▪ recommended semester: 8
Number of hours/semester: 12 lectures + 0 practices + 0 seminars = total of 12 hours
Course headcount limitations (min.-max.): 5 – 50 Prerequisites: OPG-D1E-T completed
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
The aim of the course is to give an integrative overview on the physiological, pathophysiological and pharmacological aspects of pain.
Major tasks are to (i) provide information on peripheral and central mechanisms of pain and hyperalgesia; (ii) describe the major features
of existing analgesics including opioids, non-steroidal antiinflammatory agents and adjuvant analgesics; (iii) outline novel targets for
development of analgesic drugs. The course will also help students prepare for the exams in Pharmacology 2 and 3.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
After the last lecture of the course, a written test is taken in the instruction period to obtain a mid-semester grade. Those who fail or do
not write this test have a second chance until end of Week 12 of the instruction period to improve in form of an oral conversation. Upon
failing or missing there is one more oral chance to obtain a mid-semester grade during the first two weeks of the exam period.
Making up for missed classes
There is no way to make up for missed lectures.
Reading material
- Obligatory literature
None.
- Literature developed by the Department
The material of the lectures is available in PDF format in the Neptun.
- Notes
None.
- Recommended literature
None.
Lectures
1 Basic terms related to pain and nociceptors
Dr. Pethő Gábor István
2 Features of capsaicin-sensitive nociceptors
Dr. Pethő Gábor István
3 Peripheral mechanisms of hyperalgesia
Dr. Pethő Gábor István
4 Central mechanisms of hyperalgesia and allodynia
Dr. Pethő Gábor István
5 Features of neuropathic pain
Dr. Pethő Gábor István
6 Pharmacology of opioid analgesics
Dr. Pethő Gábor István
7 Pharmacology of non-steroidal antiinflammatory analgesic drugs
Dr. Pethő Gábor István
8 Adjuvant analgesics
Dr. Pethő Gábor István
9 New targets for development of analgesics I
Dr. Pethő Gábor István
10 New targets for development of analgesics II
Dr. Pethő Gábor István
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Practices
Seminars
Exam topics/questions
No exam questions are given. The essay questions of the written exam are based on the material presented.
Participants
UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020
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OPE-IVF-T INFECTIONS AND IMMUNITY
Course director: DR. JÚLIA BARTHÓ-SZEKERES, professor
Department of Medical Biology and Central Electron Microscope Laboratory szekeres.julia@pte.hu
2 credit ▪ midsemester grade ▪ Elective subject for the Medical-biological module ▪ spring semester ▪ recommended semester: 8
Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours
Course headcount limitations (min.-max.): 2 – 25 Prerequisites: OPO-IMM-T completed + OPO-MI1-T completed
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
The importance of anti-infectious immunity is not restricted to elimination of pathogens, but is also responsible for long lasting protection,
as well as -in some cases- immunopathological disorders
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
Continuous
Making up for missed classes
Consultation
Reading material
- Obligatory literature
- Literature developed by the Department
Lecture slides
- Notes
- Recommended literature
1. H. Chapel, M. Haeney, N. Misbah, Snowden: Clinical Immunology, Blackwell, 2008
2. S. Kartikeyan, R.N. Bharmal, R.P. Tiwari, and P.S. Bisen: HIV and AIDS: Basic Elements and Priorities, 2007
3. T. Platts-Mills and Johannes Ring: Allergy in Practice, 2003
Lectures
1 Non-specific defence. Surface barriers, normal colonizing flora, phagocytosis, complement system.
Dr. Barthóné Dr. Szekeres Júlia
2 Non-specific defence. Surface barriers, normal colonizing flora, phagocytosis, complement system.
Dr. Barthóné Dr. Szekeres Júlia
3 Antigen presentation and recognition. Dendritic cells, pattern recognition receptors.
Dr. Barthóné Dr. Szekeres Júlia
4 Antigen presentation and recognition. Dendritic cells, pattern recognition receptors.
Dr. Barthóné Dr. Szekeres Júlia
5 Defence against extracellular microorganisms. The role of immunoglobulin classes. Mucosal immunity.
Dr. Barthóné Dr. Szekeres Júlia
6 Defence against extracellular microorganisms. The role of immunoglobulin classes. Mucosal immunity.
Dr. Barthóné Dr. Szekeres Júlia
7 Defence against intracellular microorganisms. Defence against viral infections. Viruses and immunosuppression.
Dr. Barthóné Dr. Szekeres Júlia
8 Defence against intracellular microorganisms. Defence against viral infections. Viruses and immunosuppression.
Dr. Barthóné Dr. Szekeres Júlia
9 Defence against parasitic infections. Micro-and macroparasite infections that polarize the immune response.
Dr. Barthóné Dr. Szekeres Júlia
10 Defence against parasitic infections. Micro-and macroparasite infections that polarize the immune response.
Dr. Barthóné Dr. Szekeres Júlia
11 Evasion and use of the innate and adaptive immune responses by microorganisms.
Dr. Barthóné Dr. Szekeres Júlia
12 Evasion and use of the innate and adaptive immune responses by microorganisms.
Dr. Barthóné Dr. Szekeres Júlia
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13 Healing of infectious diseases. The pathogenic role of anti-infectious immunity; local inflammation, systemic inflammation,
sepsis, endotoxin shock, toxic shock syndrome.
Dr. Barthóné Dr. Szekeres Júlia
14 Healing of infectious diseases. The pathogenic role of anti-infectious immunity; local inflammation, systemic inflammation,
sepsis, endotoxin shock, toxic shock syndrome.
Dr. Barthóné Dr. Szekeres Júlia
15 The pathogenic role of anti-infectious immunity; hypersensitivity reactions in bacterial-parasitic and fungal infections.
Dr. Barthóné Dr. Szekeres Júlia
16 The pathogenic role of anti-infectious immunity; hypersensitivity reactions in bacterial-parasitic and fungal infections.
Dr. Barthóné Dr. Szekeres Júlia
17 Induction of autoimmunity; molecular mimicri, epitope spreading, polyclonal T or B cell activation.
Dr. Barthóné Dr. Szekeres Júlia
18 Induction of autoimmunity; molecular mimicri, epitope spreading, polyclonal T or B cell activation.
Dr. Barthóné Dr. Szekeres Júlia
19 Immunopathological alterations following viral infections. The involvement of CD8+ T cells.
Dr. Barthóné Dr. Szekeres Júlia
20 Immunopathological alterations following viral infections. The involvement of CD8+ T cells.
Dr. Barthóné Dr. Szekeres Júlia
21 Immunopathological alterations following viral infections. The involvement of CD4+ T cells.
Dr. Barthóné Dr. Szekeres Júlia
22 Immunopathological alterations following viral infections. The involvement of antibodies.
Dr. Barthóné Dr. Szekeres Júlia
23 Vaccination; Type of vaccines, requirements for vaccines.
Dr. Barthóné Dr. Szekeres Júlia
24 Vaccination; rational vaccine development, mandatory vaccines.
Dr. Barthóné Dr. Szekeres Júlia
Practices
Seminars
Exam topics/questions
The same as lecture topics
Participants
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188
OPF-GTH-T GENE THERAPY
Course director: DR. GÉZA SÁFRÁNY, visiting professor
Institute of Laboratory Medicine gsafrany@hotmail.com
1 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 8
Number of hours/semester: 12 lectures + 0 practices + 0 seminars = total of 12 hours
Course headcount limitations (min.-max.): 3 – 30 Prerequisites: none
Topic
We wish to give a short overview about the present state of gene therapy, the current ongoing clinical trials and the potential side effects
of gene therapy and about the ethical considerations. The various viral and non-viral gene delivery protocols suitable for high efficiency
gene delivery both under in vitro and in vivo conditions will be discussed in details. Gene therapy protocols applied in the treatment of
malignant diseases will be presented together with the results of ongoing clinical trials. We will talk about the results and the potentials
of the treatments of inherited genetic disorders. One of the most promising field of the current clinical trials is the treatment of ischemic
diseases, the results will be presented. The potential applications of stem cells during gene therapy will be described, as well. Finally, we
will discuss the side effects occurring during gene therapy and the ethical considerations will also be mentioned.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
Test
Making up for missed classes
Joining later lectures, individual consultations.
Reading material
- Obligatory literature
1. Kelly K. Hunt, Stephan A. Vorburger and Stephen G. Swisher (ed.): Gene Therapy for Cancer, 2007 Humana Press Inc. 999
Riverview Drive, Suite 208 Totowa, New Jersey 07512
2. Thomas F. Kresina (ed.): Introduction to Molecular Medicine and Gene Therapy, 2001 by Wiley-Liss, Inc. ISBNs: 0-471-39188-
3 (Hardback); 0-471-22387-5 (Electronic)
- Literature developed by the Department
1. Sáfrány G.: A génterápia génsebészeti alapjai és jelenlegi helyzete, A Genom (ed.: Hídvégi EJ), Budapest, Széphalom
Könyvműhely 2003, pp 187-204
2. Sáfrány G.: A vasculáris génterápia és a csontvelőőssejt-terápia, Atherosclerosis (ed.: Császár A.), Budapest, Synergo Kiadó,
2004 pp 336-344
- Notes
- Recommended literature
http://www.genetherapynet.com/clinicaltrialsgov.html
http://www.bioportfolio.com/cgi-bin/acatalog/Human_Gene_Therapy_Course.html
http://openlearn.open.ac.uk/course/view.php?id=2430
Lectures
1 Introduction to gene therapy, ongoing clinical trials
Dr. Sáfrány Géza
2 Gene delivery protocols, viral vectors applied in gene therapy
Dr. Sáfrány Géza
3 Targeted gene delivery and targeted gene expression
Dr. Sáfrány Géza
4 Application of dendritic cells in gene therapy
Dr. Sáfrány Géza
5 Gene directed enzyme pro-drug therapy of malignant diseases
Dr. Sáfrány Géza
6 Immune therapy of malignant diseases
Dr. Sáfrány Géza
7 Gene therapy of leukaemia
Dr. Sáfrány Géza
8 Treatment of immune-deficiencies with gene therapy
Dr. Sáfrány Géza
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9 Gene therapy of ischemic diseases
Dr. Sáfrány Géza
10 Gene therapy of cystic fibrosis
Dr. Sáfrány Géza
11 Gene therapy of thalassemia
Dr. Sáfrány Géza
12 Oncolytic viruses in tumor therapy
Dr. Sáfrány Géza
Practices
Seminars
Exam topics/questions
Multiple choice tests for checking the acquisition of course material is given at the end of semester. Questions include material discussed
in lectures and seminars.
Participants
Dr. Sáfrány Géza (UYX8V2)
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OPE-GST-T SPECIAL FIELDS OF PHARMACOLOGY
Course director: DR. GÁBOR ISTVÁN PETHŐ, professor
Department of Pharmacology and Pharmacotherapy gabor.petho@aok.pte.hu
1 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ autumn semester ▪ recommended semester: 9
Number of hours/semester: 10 lectures + 0 practices + 0 seminars = total of 10 hours
Course headcount limitations (min.-max.): 5 – 50 Prerequisites: OPG-D1E-T completed
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
The aim of the course is to present those fields of pharmacology that are not covered at all or only partially discussed in the compulsory
courses Pharmacology 1-2-3 because of time limits. These are the following: use of drugs during pregnancy and lactation; significance
of pharmacogenomics in therapy and drug development, pharmacology of retinoids; other drugs used in dermatology; use of meta-
analysis in evaluation of drugs, clinical significance of basic pharmacodynamic and pharmacokinetic parameters; special aspects of drugs
used by inhalation, basics of chronopharmacology; pharmacology of contrast media, drugs and chirality. The course wishes to contribute
to a better understanding of the use of drugs in the clinical practice and may help students prepare for the pharmacology exams.
Conditions for acceptance of the semester
Maximum of 25 % absence allowed
Mid-term exams
After the last lecture of the course, a written test is taken in the instruction period to obtain a mid-semester grade. Those who fail or do
not write this test have a second chance until the end of Week 12 of the instruction period to improve in form of an oral conversation.
Upon failing or missing there is one more oral chance to obtain a mid-semester grade during the first two weeks of the exam period.
Making up for missed classes
There is no way to make up for missed lectures.
Reading material
- Obligatory literature
None.
- Literature developed by the Department
The material of the lectures is available in PDF format in the Neptun.
- Notes
None.
- Recommended literature
None.
Lectures
1 Special aspects of use of drugs during pregnancy and lactation
Dr. Pethő Gábor István
2 Significance of pharmacogenomics in therapy and drug development
Dr. Pethő Gábor István
3 Use of meta-analysis in evaluation of drugs
Dr. Pethő Gábor István
4 Drugs and chirality
Dr. Pethő Gábor István
5 Clinical significance of pharmacodynamic and pharmacokinetic parameters on the example of drugs used in respiratory diseases I
Dr. Pethő Gábor István
6 Clinical significance of pharmacodynamic and pharmacokinetic parameters on the example of drugs used in respiratory diseases II
Dr. Pethő Gábor István
7 Pharmacology of retinoids
Dr. Pethő Gábor István
8 Drugs (other than retinoids) used in dermatology
Dr. Pethő Gábor István
9 Pharmacology of contrast media
Dr. Pethő Gábor István
10 Basics of chronopharmacology
Dr. Pethő Gábor István
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Practices
Seminars
Exam topics/questions
No exam questions are given. The essay questions of the written exam are based on the material presented.
Participants
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OPE-GSI-T PHARMACEUTICAL INFORMATICS (ONLY FOR YEAR OF 2009 AND 2010)
Course director: DR. LAJOS BOTZ, professor
Department of Pharmaceutics and University Pharmacy botz.lajos@pte.hu
2 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ autumn semester ▪ recommended semester: 9
Number of hours/semester: 12 lectures + 12 practices + 0 seminars = total of 24 hours
Course headcount limitations (min.-max.): 5 – 50 Prerequisites: OPG-U3E-T completed
Topic
Students will become familiar with pharmaceutical databases, IT communication systems and drug management software applications.
Pharmaceutical IT methods such as telemedicine, or Internet pharmacies will be also covered in lectures. Lectures will give students
insight into ethical and legal aspects of information sources, and their critical evaluation. The aim of the lectures is to consolidate the
pharmaceutical IT skills of students. Students will be equipped with up-to-date pharmaceutical IT skills: use of databases and Internet
information sources.
During the semester the students will become familiar with the basics of personal computer and network systems in general and with the
specifications of pharmaceutical informatics, such as the development and stages of pharmacy informatics, principles of pharmacy
softwares. Also the different software types and drug dispensing rules used in pharmacies are introduced in this semester. The basic
knowledge of drug interactions and the available techniques and databases for screening interactions in everyday practice is also an
emphasized topic. After acquiring the principles of informatics and pharmaceutical informatics the students will be able to synthesize the
elements and understand the functions of pharmacy information management systems. Even the possibilities and threats of online drug
marketing and the capability of finding relevant and authentic pharmaceutical information on the web is the objective of this course.
Conditions for acceptance of the semester
Acceptance of term/semester (provisions of casting to examination):
- Regular attendance of classes (maximum 25 % of absence is accepted),
- Assignments given in class should be carried out during term-time and,
- Written mid-term and end-of-the term test.
Mid-term exams
Mid-term tests: During the semester a mid-term test will be written. In case of unsuccessful or missed test, additional questions will be
added to the end-of-the-term test. The number of additional questions may vary regarding the number of unsuccessful or missed mid-
term tests. There is no re-examination opportunity for the unsuccessful or missed mid-term tests.
End-of-the-term test: On the last week of the semester, a test will be written on the whole semester”s curriculum. Further additional
questions are included in the end-of-the-term test, if the student has not carried out an assignment during the semester. The number of
these questions may vary according to the unsuccessful or missed assignments. In case of unsuccessful or missed end-of-the term test,
one re-examination opportunity is granted to make up until the end of the second week of the exam period. In case of Pharmaceutical
Informatics there is midsemester grade.
Making up for missed classes
Retake opportunity is possible following personal discussion for the end-of-the term test.
Reading material
- Obligatory literature
- Literature developed by the Department
List of study aids to acquire curriculum (books, notes, other) and all presentations can be downloaded from Neptun Meet Street.
- Notes
- Recommended literature
Ed. R. Fisher: Information Technology for Pharmacists, Pharmaceutical Press
Brent I. Fox, Margaret R. Thrower, Bill G. Felkey: Building Core Competencies in Pharmacy Informatics, American Pharmacists
Association, 2010
Lectures
1 Personal computer and network system fundamentals 1.
Dr. Vida Róbert György
2 Personal computer and network system fundamentals 2.
Dr. Vida Róbert György
3 Database systems, IT and search engines 1.
Dr. Vida Róbert György
4 Database systems, IT and search engines 2.
Dr. Vida Róbert György
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5 Drug interactions, Drug interaction databases 1.
Dr. Végh Anna
6 Drug interactions, Drug interaction databases 2.
Dr. Végh Anna
7 Drug interactions, Drug interaction databases 3.
Dr. Végh Anna
8 Drug interactions, Drug interaction databases 4.
Dr. Végh Anna
9 Pharmaceutical Information Management Systems 1.
Dr. Fittler András Tamás
10 Pharmaceutical Information Management Systems 2.
Dr. Fittler András Tamás
11 Midterm test
Dr. Fittler András Tamás
12 End-of-the term test
Dr. Vida Róbert György
Practices
1 Evidence Based Medicine - Critical Appraisal.
2 Evidence Based Medicine: Outcome Measures.
3 Evidence Based Medicine: Calculations.
4 Evidence Based Medicine: Interpretation of results. Practice
5 Central Clinical Pharmacy Oncology laboratory visit 1.
6 Central Clinical Pharmacy Oncology laboratory visit 2.
7 UNIV Pharmacy On site visit 1.
8 UNIV Pharmacy On site visit 2.
9 Pharmaceutical Information Management Systems 3.
10 Pharmaceutical Information Management Systems 4.
11 Midterm test
12 End-of-the term test
Seminars
Exam topics/questions
Based on the topics of the lectures and seminars.
Participants
Dr. Fittler András Tamás (IYR5HQ), Dr. Vida Róbert György (BN08GS)
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OPF-SUO-T EMERGENCY MEDICINE
Course director: DR. PÉTER LÁSZLÓ KANIZSAI, associate professor
Department of Emergency Medicine kanizsai.peter@pte.hu
1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 9
Number of hours/semester: 12 lectures + 0 practices + 0 seminars = total of 12 hours
Course headcount limitations (min.-max.): 5 – 150 Prerequisites: OPO-KL1-T completed
The subject can only be registered in case of a PASSED and valid health aptitude test!
Topic
It is prudent to understand the emergency concept for health care providers not involved in acute care. The purpose of the subject is to
understand the aims and principles of emergency care, to get familiar with emergency approach based on focused assessment and care,
risk stratification. It is also important to understand the essences of team approach and make patients comfortable by providing safe and
patient centered care within our given time-range, i.e. 24 hours.
Conditions for acceptance of the semester
Test exam.
Mid-term exams
Making up for missed classes
Personal communication with the tutors.
Reading material
- Obligatory literature
R. Aghababian: Essentials of Emergency Medicine, 2nd edition
- Literature developed by the Department
- Notes
- Recommended literature
Lectures
1 History of emergency care, emergency aspects, structured communication
Dr. Kanizsai Péter László
2 Prehospital care
Dr. Bóna Ernő
3 Triage, teamwork
Dr. Gaál Ildikó
4 Emergency group of symptoms
Dr. Szilágyi Csilla
5 Pain syndromes
Dr. Labudek Renáta
6 From door to needle (ACS and stroke care - emergency aspects)
Dr. Merész Márton
7 Environmental emergencies
Dr. Borbély Andrea Ágnes
8 Care of the severely injured
Dr. Gaál Ildikó
9 Paediatric emergency care
Dr. Bánfai Gábor László
10 Toxicology basics
Dr. Bóna Ernő
11 Sepsis in the emergency department
Dr. Kanizsai Péter László
12 Interactive consultation between the Hungarian university emergency departments
Dr. Kanizsai Péter László
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Practices
Seminars
Exam topics/questions
Website of Emergency Medicine, University of Pécs.
Participants
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