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UP FP Pharmacy major Elective and Optional subjects - Course descriptions academic year of 2019/2020 1 University of Pécs Faculty of Pharmacy PHARMACY Major STUDY PROGRAM 2019/2020 Elective and Optional subjects

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Page 1: STUDY PROGRAM 2019/2020 Elective and Optional subjectsaok.pte.hu/docs/th/file/2019-2020/IP_kurzus_eng_phar_elfak_1920.pdf · OPE-TG3-T _____ Student Project Research for Students

UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020

1

University of Pécs Faculty of Pharmacy

PHARMACY Major

STUDY PROGRAM 2019/2020

Elective and Optional subjects

Page 2: STUDY PROGRAM 2019/2020 Elective and Optional subjectsaok.pte.hu/docs/th/file/2019-2020/IP_kurzus_eng_phar_elfak_1920.pdf · OPE-TG3-T _____ Student Project Research for Students

UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020

2

1st semester

OPE-KP1-T ______ Basics of Chemistry 1 ____________________________________________________________________ 5

OPE-SKS-T ______ Inorganic Chemistry Calculations ___________________________________________________________ 7

OPE-BFA-T ______ Physical Basis of Biophysics _______________________________________________________________ 9

OPE-GOM-T _____ Poisonous Mushrooms __________________________________________________________________ 11

OPE-HPR-T ______ Health Promotion ______________________________________________________________________ 13

OPF-H1A-T ______ Medical Hungarian 1A - Communication Skills _______________________________________________ 15

OPF-BBM-T ______ Introduction to Biometrics _______________________________________________________________ 17

OPF-BFM-T ______ Problem Solving in Biometrics ____________________________________________________________ 19

OPF-DME-T ______ Cancer is Preventable! ___________________________________________________________________ 21

OPF-GEM-T ______ GMO ________________________________________________________________________________ 23

OPF-H1B-T ______ Medical Hungarian 1B - Language Points ___________________________________________________ 25

OPF-OTT-T ______ History of Medicine ____________________________________________________________________ 27

OPF-FEA-T ______ Basics of Infectious Disease Epidemiology __________________________________________________ 29

2nd semester

OPE-QAS-T ______ Quantitative Analytical Chemistry Calculation ________________________________________________ 31

OPE-ABI-T ______ Applied Biometrics _____________________________________________________________________ 33

OPE-KP2-T ______ Basics of Chemistry 2 ___________________________________________________________________ 35

OPE-FKS-T ______ Physical Chemistry Problem Solving Seminar ________________________________________________ 37

OPE-DRD-T ______ Drug Design __________________________________________________________________________ 38

OPE-ETI-T _______ Pharmacy Ethics _______________________________________________________________________ 40

OPE-GKT-T ______ History of Manufacture of Medicines _______________________________________________________ 41

OPE-JEA-T ______ Diseases of Signal Transduction ___________________________________________________________ 43

OPF-H2A-T ______ Medical Hungarian 2A - Communication Skills _______________________________________________ 45

OPF-IZM-T ______ Molecular Basis of Muscle Function ________________________________________________________ 47

OPF-XC1-T ______ Extracellular Vesicles: Basics, Isolation and Application Methods 1 _______________________________ 49

OPF-BMK-T _____ Methods and Experiments in Molecular Biology ______________________________________________ 52

OPF-H2B-T ______ Medical Hungarian 2B - Language Points ___________________________________________________ 53

OPF-MGY-T _____ Medicinal Plants in the Mecsek Mountain - Field Study 1 _______________________________________ 55

OPF-PLH-T ______ The Placebo Effect _____________________________________________________________________ 57

OPF-VVE-T ______ Vaccination, Anti-Vaccination Movements: Do More Harm than Good ____________________________ 59

OPF-BAL-T ______ Mineral and Spa Waters, Balneology _______________________________________________________ 61

3rd semester

OPE-TSA-T ______ Statistical Analysis of Thesis and Student Research Projects _____________________________________ 63

OPE-WMI-T ______ Weak Molecular Interactions _____________________________________________________________ 64

OPE-TSS-T ______ Medical Applications of Mass Spectrometry _________________________________________________ 66

OPE-BEE-T ______ Basics of Epidemiology _________________________________________________________________ 68

OPE-EHS-T ______ Hunger, Satiety and Disturbances of Body Weight Regulation ____________________________________ 70

OPF-TG1-T ______ Student Project Research for Students of Pharmaceutist Programme 1______________________________ 72

OPF-TMB-T ______ Molecular Biology of Tumors _____________________________________________________________ 73

OPF-SSG-T ______ Histology Seminar for Pharmacy Students ___________________________________________________ 75

OPF-MGE-T ______ Molecular Gerontology __________________________________________________________________ 77

OPF-IPM-T ______ Innovation and Project Management from a Business Perspective (KÜLÖN KURZUS!!!) ______________ 79

OPF-HB1-T ______ How to Achieve Better Grade in Organic Chemistry 1 __________________________________________ 81

OPF-EBK-T ______ Food Safety and Crisis Situations __________________________________________________________ 83

OPF-H3B-T ______ Medical Hungarian 3B - Medical Communication in Practice for Students of Pharmacy ________________ 85

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UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020

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OPF-H3A-T ______ Medical Hungarian 3A - Basics of Medical Communication for Students of Pharmacy_________________ 87

4th semester

OPE-BKM-T _____ Basic Methods of Scientific Research _______________________________________________________ 89

OPE-GMO-T _____ Modelling the Structure and Interactions of Bioactive Molecules__________________________________ 91

OPE-SME-T ______ Spectrometric Identification of Organic Compounds ___________________________________________ 94

OPE-TIZ-T _______ Central Regulation of Feeding and Metabolism. New Approaches _________________________________ 96

OPF-QBI-T ______ Quantum Biology: Quantum Phenomena in Biological Processes _________________________________ 98

OPF-GMI-T ______ Gyógyszerészek a mindennapokban - ANGOL VÁLTOZAT ___________________________________ 101

OPF-H4A-T ______ Medical Hungarian 4A - Basics of Medical Communication for Students of Pharmacy________________ 103

OPF-H4B-T ______ Medical Hungarian 4B - Medical Communication in Practice for Students of Pharmacy _______________ 105

OPF-HB2-T ______ How to Achieve Better Grade in Organic Chemistry 2 _________________________________________ 107

OPF-VAN-T ______ Iron Metabolism: from Molecular Mechanisms to Clinical Consequences __________________________ 109

OPF-SKI-T _______ Basics of Chemical Informatics __________________________________________________________ 111

OPF-CSU-T ______ Miracles of Living Materials ("Realistic" Biochemistry) _______________________________________ 113

OPF-TG2-T ______ Student Project Research for Students of Pharmaceutist Programme 2_____________________________ 115

5th semester

OPE-EFA-T ______ Ethnopharmacobotany __________________________________________________________________ 116

OPE-TG3-T ______ Student Project Research for Students of Pharmaceutist Programme 3_____________________________ 118

OPE-GMK-T _____ Qualitative and Quantitative Analysis of Drugs from Human Tissue ______________________________ 119

OPF-MOD-T _____ Molecular Diagnostics__________________________________________________________________ 121

OPF-MME-T _____ Molecular Medicine ___________________________________________________________________ 123

OPF-MOT-T ______ Molecular Therapies ___________________________________________________________________ 125

OPF-HVS-T ______ Synthesis of Heterocyclic Compounds and Their Application in Therapy __________________________ 127

OPF-GLK-T ______ Bioinorganic Chemistry for Pharmacy Students ______________________________________________ 129

OPF-TS1-T ______ Calculations in Pharmaceutical Technology 1 _______________________________________________ 131

OPF-GKG-T ______ Gas Chromatography __________________________________________________________________ 132

OPF-EGZ-T ______ Exotic Medicinal Plants ________________________________________________________________ 134

ATT5-T _________ Physical Education 5 ___________________________________________________________________ 136

OPF-VGG-T ______ Collecting and Conservation of Wild Native Medicinal Plants ___________________________________ 137

OPF-GMT-T ______ Drug Metabolism and Drug Toxicity ______________________________________________________ 139

6th semester

OPE-STK-T ______ Basics of Stereochemistry _______________________________________________________________ 141

OPF-SNA-T ______ Carbon Nanostructures _________________________________________________________________ 143

OPE-VFM-T ______ Business Development and Management ___________________________________________________ 145

OPE-TG4-T ______ Student Project Research for Students of Pharmaceutist Programme 4_____________________________ 147

OPE-GFK-T ______ Physico-Chemical Bases of Drug Action ___________________________________________________ 148

OPE-FAO-T ______ Applied Health Economics ______________________________________________________________ 150

OPE-ASZ-T ______ The Antimicrobial Drugs and their Clinical Use ______________________________________________ 152

OPE-KPR-T ______ Chemoprevention _____________________________________________________________________ 154

OPF-TS2-T ______ Calculations in Pharmaceutical Technology 2 _______________________________________________ 156

OPF-DTS-T ______ The Role of Drug Transporters ___________________________________________________________ 157

OPF-EXT-T ______ Extraction and Chromatographic Techniques in Medicinal Plant Analysis _________________________ 160

OPF-KNH-T ______ Psychoactive Plants ____________________________________________________________________ 162

OPF-NSG-T ______ Plant Products in the Pharmaceutical Practice________________________________________________ 164

OPF-PNT-T ______ Pharmaceutical Nanotechnology __________________________________________________________ 166

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UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020

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7th semester

OPE-FMA-T ______ Data Analysis 1 _______________________________________________________________________ 168

OPE-FM2-T ______ Data Analysis 2 _______________________________________________________________________ 170

OPE-T2F-T ______ Pharmaceutical Biotechnology and its links to Biopharmaceuticals _______________________________ 172

OPE-SHK-T ______ Design and Industrial Manufacture of Medicines _____________________________________________ 174

OPF-KIA-T ______ Essential Oils and Clinical Aromatherapy ___________________________________________________ 176

OPF-XES-T ______ The Fate of Drug ______________________________________________________________________ 178

8th semester

OPE-DRO-T ______ Drug and Substance Abuse ______________________________________________________________ 180

OPE-MGT-T _____ Pharmaceutical Technology of Modified Drug Release ________________________________________ 182

OPE-FAJ-T ______ Pain and Analgesics ___________________________________________________________________ 184

OPE-IVF-T ______ Infections and Immunity ________________________________________________________________ 186

OPF-GTH-T ______ Gene Therapy ________________________________________________________________________ 188

9th semester

OPE-GST-T ______ Special Fields of Pharmacology __________________________________________________________ 190

OPE-GSI-T ______ Pharmaceutical Informatics (ONLY FOR YEAR OF 2009 AND 2010) ____________________________ 192

OPF-SUO-T ______ Emergency Medicine __________________________________________________________________ 194

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UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020

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OPE-KP1-T BASICS OF CHEMISTRY 1

Course director: DR. PÁL PERJÉSI, professor

Department of Pharmaceutical Chemistry [email protected]

2 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ autumn semester ▪ recommended semester: 1

Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours

Course headcount limitations (min.-max.): 5 – 40 Prerequisites: none

Topic

The course provides an overview of the basic laws of Chemistry concentrating on those that are ubiquitous in the chemistry-related

subjects of the basic modules of the health-related curriculums. The course helps understanding the chemistry-related compulsory

subjects of the modules.

Conditions for acceptance of the semester

The course is in accord with the Code of Studies and Examinations. Participation in the lectures is obligatory. Maximum three absences

can be accepted both from lectures and practices.

Two written will be written during the semester. The result of one of them should be at least 60%, the average of the two should be at

least 50%. The result of the improving test is combined with those of the two midterm tests.

Mid-term exams

Two written will be written during the semester. The result of one of them should be at least 60%, the average of the two should be at

least 50%. The result of the improving test is combined with those of the two midterm tests

Making up for missed classes

There is no opportunity to make up missed classes.

Reading material

- Obligatory literature

Ebbing D.D., Gammon S.D.: General Chemistry, Houghton Miffilin Co., Boston, 2009

- Literature developed by the Department

Almási A., Kuzma M., Perjési P.: General and Inorganic Chemistry - Laboratory Techniques and Practices, electronic educational

material, University of Pécs, 2014

- Notes

- Recommended literature

en.wikibooks.org/wiki/General_Chemistry

Lectures

1 The electronic structure of atom. Elements.

Dr. Perjési Pál

2 The electronic structure of atom. Elements.

Dr. Perjési Pál

3 Chemical bonds. Geometry of molecules.

Dr. Perjési Pál

4 Chemical bonds. Geometry of molecules.

Dr. Perjési Pál

5 Kinetic theory of gases. Gas laws.

Dr. Perjési Pál

6 Kinetic theory of gases. Gas laws.

Dr. Perjési Pál

7 Liquids and solutions. Concentrations.

Dr. Perjési Pál

8 Liquids and solutions. Concentrations.

Dr. Perjési Pál

9 Colligative properties.

Dr. Perjési Pál

10 Colligative properties.

Dr. Perjési Pál

11 Chemical thermodynamics I.

Dr. Perjési Pál

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UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020

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12 Chemical thermodynamics I.

Dr. Perjési Pál

13 Chemical kinetics.

Dr. Perjési Pál

14 Chemical kinetics.

Dr. Perjési Pál

15 Chemical equilibrium I. Homogeneous equilibria.

Dr. Perjési Pál

16 Chemical equilibrium I. Homogeneous equilibria.

Dr. Perjési Pál

17 Chemical equilibrium II. Acid-base equilibriums in solution.

Dr. Perjési Pál

18 Chemical equilibrium II. Acid-base equilibriums in solution.

Dr. Perjési Pál

19 Chemical equilibrium III. Heterogeneous equilibria.

Dr. Perjési Pál

20 Chemical equilibrium III. Heterogeneous equilibria.

Dr. Perjési Pál

21 Chemical equilibrium IV. Chemical thermodynamics II.

Dr. Perjési Pál

22 Chemical equilibrium IV. Chemical thermodynamics II.

Dr. Perjési Pál

23 Electrochemistry I. Conductivity of electrolytes.

Dr. Perjési Pál

24 Electrochemistry I. Conductivity of electrolytes.

Dr. Perjési Pál

25 Electrochemistry II. Electrode potential. Galvanic cells.

Dr. Perjési Pál

26 Electrochemistry II. Electrode potential. Galvanic cells.

Dr. Perjési Pál

27 Electrochemistry III. Electrolysis.

Dr. Perjési Pál

28 Electrochemistry III. Electrolysis.

Dr. Perjési Pál

Practices

Seminars

Exam topics/questions

Written tests covering the topics of the lectures.

Participants

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UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020

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OPE-SKS-T INORGANIC CHEMISTRY CALCULATIONS

Course director: DR. ZSUZSANNA ROZMER, assistant professor

Department of Pharmaceutical Chemistry [email protected]

2 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ autumn semester ▪ recommended semester: 1

Number of hours/semester: 0 lectures + 0 practices + 28 seminars = total of 28 hours

Course headcount limitations (min.-max.): 5 – 70 Prerequisites: none

Topic

This subject is based on the acquired theoretical knowledge on General and Inorganic Chemistry, with adaptation of the principles to

solve chemical problems. The aim of this course to solve chemical calculations related to the lessons of General and Inorganic Chemistry

1 and give a support for easier understanding of the subject.

Conditions for acceptance of the semester

According to the Code of Studies and Examinations (see on the homepage). During the semester maximum 3 missed classes are

acceptable. Two midterm tests will be written during the semester on the 7th and the 12th weeks. The result of both tests should be above

60%. One re-take chance is allowed.

Mid-term exams

Two written exams during the semester.

Making up for missed classes

There is no opportunity to make up missed classes.

Reading material

- Obligatory literature

Ebbing D.D., Gammon S.D.: General Chemistry, Houghton Miffilin Co., Boston, 2009.

- Literature developed by the Department

Almási A., Kuzma M., Perjési P.: General and Inorganic Chemistry - Laboratory Techniques and Calculations, electronic educational

material, University of Pécs, 2014

- Notes

- Recommended literature

en.wikibooks.org/wiki/General_Chemistry

Lectures

Practices

Seminars

1 Introduction to the calculations on inorganic chemistry (basis of chemistry). Stochiometric calculations.

2 Introduction to the calculations on inorganic chemistry (basis of chemistry). Stochiometric calculations.

3 Stochiometric calculations. Calculation of concentrations.

4 Stochiometric calculations. Calculation of concentrations.

5 Calculation of concentrations, Solubility.

6 Calculation of concentrations, Solubility.

7 Electrolytic dissociation.

8 Electrolytic dissociation.

9 Kolligative properites.

10 Kolligative properites.

11 Thermochemistry (Hess’ Law).

12 Thermochemistry (Hess’ Law).

13 Chemical kinetics. Test 1

14 Chemical kinetics. Test 1

15 pH calculations I.: Hydrolysis of salts.

16 pH calculations I.: Hydrolysis of salts.

17 pH calculations II: Buffers.

18 pH calculations II: Buffers.

19 Solubility equilibria.

20 Solubility equilibria.

21 Calculations based on the balancing of redox equations I

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UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020

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22 Calculations based on the balancing of redox equations I

23 Calculations based on the balancing of redox equations II

24 Calculations based on the balancing of redox equations II

25 Calculations on electrochemistry I. Test 2

26 Calculations on electrochemistry I. Test 2

27 Calculations on electrochemistry II

28 Calculations on electrochemistry II

Exam topics/questions

The final grade is established based on the average of each written exams.

Participants

Dr. Almási Attila (KJ5MBZ), Dr. Kulcsár Győző Kornél (R7V5ZT), Dr. Lemli Beáta (WT72P7)

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UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020

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OPE-BFA-T PHYSICAL BASIS OF BIOPHYSICS

Course director: DR. EMŐKE BÓDIS, assistant professor

Department of Biophysics [email protected]

2 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ both semesters ▪ recommended semester: 1

Number of hours/semester: 0 lectures + 0 practices + 24 seminars = total of 24 hours

Course headcount limitations (min.-max.): 5 – 150 Prerequisites: none

Topic

The course addresses the chapters of physics which are necessary for a proper understanding of Biophysics (lecture and practicals).

Beyond theoretical discussions, example problems are solved.

Conditions for acceptance of the semester

Maximum 3 absence is allowed.

Mid-term exams

Making up for missed classes

There is no option.

Reading material

- Obligatory literature

- Literature developed by the Department

- Notes

Course related information can be found on the website of the Department of Biophysics (http://biofizika.aok.pte.hu).

- Recommended literature

As a base, any secondary school physics book is useful.

Lectures

Practices

Seminars

1 Mathematical basics. Scalars and vectors

2 Physical quantities and units

3 Newton's laws

4 Conservation of momentum. Collisions

5 Motion on a straight line. Kinetics

6 Motion on a straight line. Dynamics

7 Circular motion, rotation

8 Oscillations

9 Work and energy. Friction

10 The work-energy theorem. Conservation of mechanical energy

11 Hydrostatics

12 Hydrodynamics

13 First and second law of thermodynamics

14 Thermodynamic potentials

15 Electrostatics

16 Ohm's law, Kirchhoff's laws

17 Magnetostatics

18 Magnetic induction

19 Waves

20 Wave- and geometrical optics

21 Atom- and nuclear physics

22 Electromagnetic waves

23 Test writing

24 Test writing

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UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020

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Exam topics/questions

Can be found on the website of the Department of Biophysics (http://biofizika.aok.pte.hu)

The seminar strengthens physics theoretical background and provide further understanding through evaluation of exercises (calculations)

hence the written test at the end of the semester includes theoretical questions and exercises.

Participants

Dr. Szabó-Meleg Edina (I0NKTU), Dr. Talián Csaba Gábor (RP9GGL), Leipoldne Víg Andrea Teréz (OL4J1R), Szatmári Dávid

(AIX2L6), Takács-Kollár Veronika Tünde (L5EB78), Tóth Mónika Ágnes (GC6VTC)

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UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020

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OPE-GOM-T POISONOUS MUSHROOMS

Course director: DR. LORÁND BARTHÓ, professor

Department of Pharmacology and Pharmacotherapy [email protected]

2 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ autumn semester ▪ recommended semester: 1

Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours

Course headcount limitations (min.-max.): 5 – 40 Prerequisites: none

Topic

Family physicians may play an important role in the early identification and management of mushroom poisoning (MP).

This course:

- deals with the various types of MP and their symptoms;

- molecular mechanisms encountered with the effects of cytotoxic MPs

- morphological features of the most important toxic mushrooms/fungi and their edible counterparts.

Conditions for acceptance of the semester

- Attending at least 75% of the lessons, passing the oral exam

- Oral exam includes matters of poisonings, as well as recognizing the most important PMs and their edible counterparts

Mid-term exams

Exam on week 12

Making up for missed classes

Individual

Reading material

- Obligatory literature

--

- Literature developed by the Department

CD prepared by Prof. Barthó

Most terms will be explained in the lectures.

- Notes

--

- Recommended literature

--

Lectures

1 Introduction

Dr. Barthó Loránd

2 Amanitas, Lepiotas (parasols) and their poisonings

Dr. Barthó Loránd

3 Amanitas, Lepiotas (parasols) and their poisonings

Dr. Barthó Loránd

4 Amanitas, Lepiotas (parasols) and their poisonings

Dr. Barthó Loránd

5 Amanitas, Lepiotas (parasols) and their poisonings

Dr. Barthó Loránd

6 Other mushrooms with white spores and their poisonings

Dr. Barthó Loránd

7 Other mushrooms with white spores and their poisonings

Dr. Barthó Loránd

8 Mushrooms with pink, brown or black spores

Dr. Barthó Loránd

9 Mushrooms with pink, brown or black spores

Dr. Barthó Loránd

10 Mushrooms with pink, brown or black spores

Dr. Barthó Loránd

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UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020

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11 Mushrooms with tubes, pores, wrinkles or spines

Dr. Barthó Loránd

12 Mushrooms with tubes, pores, wrinkles or spines

Dr. Barthó Loránd

13 Molecular mechanisms encountered with the effects of cytotoxic MPs

Dr. Szeberényi József

14 Molecular mechanisms encountered with the effects of cytotoxic MPs

Dr. Szeberényi József

15 Morels, false morels, puff-balls, corals, etc. Pre-exam

Dr. Barthó Loránd

16 Morels, false morels, puff-balls, corals, etc. Pre-exam

Dr. Barthó Loránd

17 Some forensic aspects of MPs

Dr. Barthó Loránd

18 Muscarine, muscimol, ibotenic acid

Dr. Barthó Loránd

19 Coprin, orellanin, aflatoxin

Dr. Barthó Loránd

20 Reprise of poisonous mushrooms

Dr. Barthó Loránd

21 Toxins of moulds

Dr. Barthó Loránd

22 Tasks of GP sin case of MP

Dr. Barthó Loránd

23 Reprise of types of poisoning; Exam

Dr. Barthó Loránd

24 Exam

Dr. Barthó Loránd

Practices

Seminars

Exam topics/questions

Oral exam including matters of poisonings, as well as recognizing the most important PMs and their edible counterparts

Cytotoxic MPs

Gastrointestinal MP

Muscarine-type of MP

Psychotropic MP

Other types of MP

Tasks of the general practitioner in case of MP

Participants

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UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020

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OPE-HPR-T HEALTH PROMOTION

Course director: DR. ISTVÁN ZOLTÁN KISS, professor

Department of Public Health Medicine [email protected]

2 credit ▪ midsemester grade ▪ Elective subject for the Medical-biological module ▪ autumn semester ▪ recommended semester: 1

Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours

Course headcount limitations (min.-max.): 5 – 20 Prerequisites: none

Topic

Health promotion is intimately related not only to preventive medicine, but to the everyday practice of physicians as well. A considerable

part of noninfectious diseases is preventable, morbidity and mortality of these illnesses are decreasable by the implementation of effective

intervention.

Conditions for acceptance of the semester

Maximum of 15 % absence allowed

Mid-term exams

Neptun Meet Street

Making up for missed classes

There are no make-up classes

Reading material

- Obligatory literature

- Literature developed by the Department

Education material on Neptun

- Notes

- Recommended literature

Lectures

1 Definitions of health. Health and its relation to everyday life.

Dr. Horváth-Sarródi Andrea

2 Theoretical background of health promotion. Salutogenesis and pathogenesis.

Dr. Horváth-Sarródi Andrea

3 Health promotion and health education.

Dr. Horváth-Sarródi Andrea

4 Basic documents of health promotion.

Dr. Horváth-Sarródi Andrea

5 Methods of health promotion.

Dr. Horváth-Sarródi Andrea

6 Measuring of results in health promotion activities. Evidence based health promotion.

Dr. Horváth-Sarródi Andrea

7 Health promotion and health policy.

Dr. Horváth-Sarródi Andrea

8 Lalonde model. Health in all policies (HiAP).

Dr. Horváth-Sarródi Andrea

9 Multisectorality. Stakeholders.

Dr. Horváth-Sarródi Andrea

10 Health Impact Assessment (HIA).

Dr. Horváth-Sarródi Andrea

11 Health promotion in communities.

Dr. Horváth-Sarródi Andrea

12 Health planning.

Dr. Horváth-Sarródi Andrea

13 SWOT-analysis.

Dr. Horváth-Sarródi Andrea

14 Personal health planning.

Dr. Horváth-Sarródi Andrea

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UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020

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15 Effective health promotion in settings (schools)

Dr. Horváth-Sarródi Andrea

16 Effective health promotion in settings (work places)

Dr. Horváth-Sarródi Andrea

17 Health Promoting Universities.

Dr. Horváth-Sarródi Andrea

18 Actuality and possibilities of the concept of Health Promoting Universities.

Dr. Horváth-Sarródi Andrea

19 Methods of mental health promotion.

Dr. Horváth-Sarródi Andrea

20 Promotion of positive mental health and possibilities of prevention of mental disorders.

Dr. Horváth-Sarródi Andrea

21 Mental health policy.

Dr. Horváth-Sarródi Andrea

22 Role of physicians in the primary, secondary and tertiary levels of prevention.

Dr. Horváth-Sarródi Andrea

23 Complex health promotion programs.

Dr. Horváth-Sarródi Andrea

24 Examples for effective health promotion activities.

Dr. Horváth-Sarródi Andrea

Practices

Seminars

Exam topics/questions

Neptun Meet Street

Participants

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OPF-H1A-T MEDICAL HUNGARIAN 1A - COMMUNICATION SKILLS

Course director: DR. VILMOS WARTA, associate professor

Department of Languages for Specific Purposes [email protected]

2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 1

Number of hours/semester: 0 lectures + 0 practices + 24 seminars = total of 24 hours

Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPE-H1B-T parallel

Topic

To establish basic skills in reading, writing, listening and speaking Hungarian in preparation for effective medical communication.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Written midterm and end of the term tests are compulsory. Other short written tests to be discussed with the course tutor in each individual

case. Several oral tests are taken, dates are to be discussed with the course tutor. Make up tests possible only during the semester classes.

Making up for missed classes

Participation in class work is obligatory. In case absences exceed 25% of total class time, the course will be regarded as uncompleted. In

the case of absences up to 25% of total class time, oral examination will have to be taken

Reading material

- Obligatory literature

Anamnézis magyarul (Magyar orvosi szaknyelv kezdőknek) by Renáta Halász, 2015. Pécs

- Literature developed by the Department

In-house course book: at the homepage of the institute:

http://aok.pte.hu/index.php?page=egyseg&egy_id=60&menu=okt_anyag&nyelv=eng

- Notes

In-house course book: at the homepage of the institute:

http://aok.pte.hu/index.php?page=egyseg&egy_id=60&menu=okt_anyag&nyelv=eng

- Recommended literature

http://aok.pte.hu/index.php?page=egyseg&egy_id=60&menu=okt_anyag&nyelv=eng

Lectures

Practices

Seminars

1 Greeting people, formality and informality

2 Greeting people, formality and informality

3 Addressing people, men and women

4 Addressing people, men and women

5 Starting conversation, the elderly and children

6 Starting conversation, the elderly and children

7 Introducing, equal and unequal relations

8 Introducing, equal and unequal relations

9 Nutritional History Taking

10 Nutrients

11 Nutrients

12 Test 1

13 Health Preservation, Sports, Addictions

14 Writing CV, occupation, work

15 Medical Specialties, Consulting Room and Ward

16 Telling CV, family relations

17 Introducing family

18 Introducing family

19 Describing people - Internal and external features

20 Describing people - Internal and external features

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21 Health care institutions, consolidation

22 Test 2

23 Evaluation

24 Evaluation

Exam topics/questions

Two written test papers and oral presentation topics to be discussed with the course tutor in each individual case.

Participants

Dávidovics Anna (U5A10Z), Dr. Hegedűs Anita (TQQEMK), Dr. Hild Gabriella (HILSWV), Dr. Németh Tímea (X8VRGN), Dr. Rébék-

Nagy Gábor (DGOZG1), Dr. Warta Vilmos (SJYRAV), Eklicsné Dr. Lepenye Katalin (JMXXSC), Krommer Zoltán (MQ5HNA),

Kurdiné Molnár Eszter (VUCECC), Nagy Gabriella (CYMRX3), Nagy Renáta (), Ronczykné Berta Anikó (CJZOFU), Szalai-Szolcsányi

Judit (RBGAPH), Szántóné Dr. Csongor Alexandra (UDKY0J)

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OPF-BBM-T INTRODUCTION TO BIOMETRICS

Course director: DR. LÁSZLÓ PÓTÓ, associate professor

Institute of Bioanalysis [email protected]

1 credit ▪ midsemester grade ▪ Optional subject ▪ both semesters ▪ recommended semester: 1

Number of hours/semester: 0 lectures + 12 practices + 0 seminars = total of 12 hours

Course headcount limitations (min.-max.): 1 – 20 Prerequisites: none

Topic

Exploring data (using graphs and numbers) are usually handled as one-lesson ‘first chapter’ by basic statistical courses. This is, because

a first course in statistics introduces many new skills. It also introduces some new ideas, that all are ‘hard to understand’ for students.

The new approach is to make a solid foundation to learn statistics by a more thorough introduction to those: The course tries to make

clear a few of these fundamental ideas of statistics - limited to understanding and working with data. An improved skill for exploring

data is useful not only at your classes and your future job but in the everyday life as well.

Conditions for acceptance of the semester

Maximum one missed class.

Mid-term exams

Active participation at the classes.

Making up for missed classes

One extra class

Reading material

- Obligatory literature

- Literature developed by the Department

- Notes

László Pótó: Biometrics, workbook, Pécs, 2018

- Recommended literature

1, Moore, D. S.: The Basic Practice of Statistics, 7th edition, 2015

2, Moore, David S., McCabe, George P.: Introduction to the Practice of Statistics, 5th edition, W.H. Freeman, 2005

and

Yates, Dan, Moore, David S., Starnes, Daren S.: The Practice of Statistics (TI-83/89 Graphing Calculator Enhanced) 2/e, W.H.

Freeman, 2003 or

3, Rees, W. G.: Essential Statistics, Chapman and Hall, 1992

Lectures

Practices

1 Probability examples 1

Dr. Pótó László

2 Probability examples 1

Dr. Pótó László

3 Probability examples 2 - discrete distributions

Dr. Pótó László

4 Probability examples 2 - discrete distributions

Dr. Pótó László

5 Exploring data by graphs

Dr. Pótó László

6 Exploring data by graphs

Dr. Pótó László

7 Exploring data by numbers - sample measures

Dr. Pótó László

8 Exploring data by numbers - sample measures

Dr. Pótó László

9 The normal distribution

Dr. Pótó László

10 The normal distribution

Dr. Pótó László

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11 Distribution of the mean; Stat estimation: the CI for the expected value

Dr. Pótó László

12 Distribution of the mean; Stat estimation: the CI for the expected value

Dr. Pótó László

Seminars

Exam topics/questions

No exam - but active participation on the classes is a must.

Participants

Dr. Pótó László (FIO4UU)

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OPF-BFM-T PROBLEM SOLVING IN BIOMETRICS

Course director: DR. LÁSZLÓ PÓTÓ, associate professor

Institute of Bioanalysis [email protected]

1 credit ▪ midsemester grade ▪ Optional subject ▪ both semesters ▪ recommended semester: 1

Number of hours/semester: 0 lectures + 12 practices + 0 seminars = total of 12 hours

Course headcount limitations (min.-max.): 1 – 20 Prerequisites: none

The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

Give a chance to have more practice to solve problems in Biometrics using PC and the SPSS software in the computer room. This was a

regular need of the students earlier since the special way how a MD should handle the typical medical problems (special way of thinking)

was not founded by the secondary school education. This foundation is an important focus point of the Biometrics course. It seems, the

weekly 1+1 lectures were not enough for most of the students for completing this important goal: To develop some brand new skills.

This course offers an organized way for that extra practices. It offers also some ‘brushing up’ chances for those who has completed

Biometrics earlier.

Conditions for acceptance of the semester

Maximum one missed class

Mid-term exams

Active participation on the classes.

Making up for missed classes

One extra class

Reading material

- Obligatory literature

- Literature developed by the Department

- Notes

László Pótó: Biometrics, workbook, Pécs, 2018.

- Recommended literature

1, Moore, D. S.: The Basic Practice of Statistics, 7th edition, 2015.

or

2, Moore, David S., McCabe, George P.: Introduction to the Practice of Statistics, 5th edition, W.H. Freeman, 2005

and

Yates, Dan, Moore, David S., Starnes, Daren S.: The Practice of Statistics (TI-83/89 Graphing Calculator Enhanced) 2/e, W.H.

Freeman, 2003 or

3, Rees, W. G.: Essential Statistics, Chapman and Hall, 1992

Lectures

Practices

1 The one sample (and the paired samples) t test

Dr. Pótó László

2 The one sample (and the paired samples) t test

Dr. Pótó László

3 The CI and the hypothesis testing - the type one and type two errors.

Dr. Pótó László

4 The CI and the hypothesis testing - the type one and type two errors. MDM basics 1.

Dr. Pótó László

5 The independent samples t test

Dr. Pótó László

6 The independent samples t test

Dr. Pótó László

7 The linear regression

Dr. Pótó László

8 The linear regression

Dr. Pótó László

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9 The contingency tables - the chi squares test

Dr. Pótó László

10 The contingency tables - the chi squares test. MDM-1/2

Dr. Pótó László

11 The nonparametric tests

Dr. Pótó László

12 The nonparametric tests. MDM basics 2.

Dr. Pótó László

Seminars

Exam topics/questions

No exam but active participation on the classes is a must.

Participants

Dr. Pótó László (FIO4UU)

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OPF-DME-T CANCER IS PREVENTABLE!

Course director: DR. ISTVÁN ZOLTÁN KISS, professor

Department of Public Health Medicine [email protected]

2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 1

Number of hours/semester: 22 lectures + 2 practices + 0 seminars = total of 24 hours

Course headcount limitations (min.-max.): 5 – 30 Prerequisites: none

Topic

One of the major challenges for the health care system of the 21st century is the high number of cancer caused deaths. Over the past

decades, despite a significant development on the field of medicine, the prognosis of this disease is still not satisfactory. Thus prevention

has a key role in in the fight against cancer. The course gives a description on the different types of cancer their major risk factors for a

more detailed understanding. Methods of cancer prevention will be described and emphasized - including theoretical knowledge and a

practical guide as well. During the course the results of most recent human epidemiological studies on cancer will also be described.

Conditions for acceptance of the semester

Participation in lectures and practicals is obligatory which is registered. Absences should not exceed 4x45 min. Otherwise signature of

grade book is denied.

Mid-term exams

Making up for missed classes

There are no make-up classes.

Reading material

- Obligatory literature

- Literature developed by the Department

Educational material uploaded on Neptun.

- Notes

- Recommended literature

Robert Weinberg (ed.): The Biology of Cancer, Garland Science 2006 ISBN 0815340788

Boffetta P., La Veccia: Neoplasms 2009. In Detels R, Beaglehole R, Lansang MA and Gulliford M (eds.) Oxford Textbook of Public

Health, 5th ed., Oxfort University Press

Lectures

1 Cancer in the 21st century

Dr. Kiss István Zoltán

2 Cancer in developing and developed countries

Dr. Kiss István Zoltán

3 The process of carcinogenesis I.

Dr. Kiss István Zoltán

4 The process of carcinogenesis II.

Dr. Kiss István Zoltán

5 Characteristics of cancer cells

Dr. Kiss István Zoltán

6 Molecular epidemiology of cancer

Dr. Kiss István Zoltán

7 The most important cancer risk factors in general I.

Dr. Kiss István Zoltán

8 The most important cancer risk factors in general II.

Dr. Kiss István Zoltán

9 Lung cancer

Dr. Kiss István Zoltán

10 Colorectal tumors I.

Dr. Kiss István Zoltán

11 Colorectal tumors II.

Dr. Kiss István Zoltán

12 Breast cancer

Dr. Kiss István Zoltán

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13 Prostate cancer

Dr. Kiss István Zoltán

14 Head and neck cancer

Dr. Kiss István Zoltán

15 Pancreatic cancer

Dr. Kiss István Zoltán

16 Gastric cancer

Dr. Kiss István Zoltán

17 Liver cancer

Dr. Kiss István Zoltán

18 Cervical cancer

Dr. Kiss István Zoltán

19 Ovarian cancer

Dr. Kiss István Zoltán

20 Skin cancer

Dr. Kiss István Zoltán

21 Leukemia

Dr. Kiss István Zoltán

22 Less frequent tumors

Dr. Kiss István Zoltán

Practices

1 Genetics, genomics and epigenetics in cancer prevention

2 Cancer prevention - Recommendations

Seminars

Exam topics/questions

Neptun

Participants

Dr. Kiss István Zoltán (EFZCGE)

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OPF-GEM-T GMO

Course director: DR. ZOLTÁN GYÖNGYI, senior research fellow

Department of Public Health Medicine [email protected]

2 credit ▪ midsemester grade ▪ Optional subject ▪ both semesters ▪ recommended semester: 1

Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours

Course headcount limitations (min.-max.): 3 – 30 Prerequisites: none

Topic

The application of genetically modified organisms (GMOs) gains more and more ground in food industry. Over the direct health effect,

they have an impact on human economy, health and environment. The topic provokes social debate, in which, in lack of information,

delusions also appear. The tecnology is also used in industry, science and human therapy. During the education, students receive a

knowledge of molecular background of production GMOs, their possible health risks, their occurrence in foodstuffs, medical applications,

detection, regulations, authorization, economical and social impacts.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Providing a new date after individual consultation.

Making up for missed classes

none

Reading material

- Obligatory literature

- Literature developed by the Department

Slides on the Neptun

- Notes

- Recommended literature

Lectures

1 Definition of GMO

Dr. Gyöngyi Zoltán

2 Needs of GMOs in different disciplines

Dr. Gyöngyi Zoltán

3 The development of agriculture to GMOs

Dr. Gyöngyi Zoltán

4 The role of GMOs in crop production

Dr. Gyöngyi Zoltán

5 The role of GMOs in animal breeding

Dr. Gyöngyi Zoltán

6 Impact of GM crops on natural habitats and organic farming

Dr. Gyöngyi Zoltán

7 GMO production. History of science

Dr. Gyöngyi Zoltán

8 GMO production. Description of biotechnology methods

Dr. Gyöngyi Zoltán

9 GMO detection methods

Dr. Gyöngyi Zoltán

10 Occurrence of GM organisms in food, their detectability

Dr. Gyöngyi Zoltán

11 GMO in industry

Dr. Gyöngyi Zoltán

12 GMO in the pharmaceutical industry

Dr. Gyöngyi Zoltán

13 GMO in science

Dr. Gyöngyi Zoltán

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14 GMO and disease prevention

Dr. Gyöngyi Zoltán

15 GMO and therapy

Dr. Gyöngyi Zoltán

16 The past, present and future of gene therapy

Dr. Gyöngyi Zoltán

17 Genetic modification of humans

Dr. Gyöngyi Zoltán

18 Potential health effects of GMOs

Dr. Gyöngyi Zoltán

19 Background of deaths caused by GMOs

Dr. Gyöngyi Zoltán

20 Preventing the harmful effects of GMOs

Dr. Gyöngyi Zoltán

21 Authorization procedures of GMOs

Dr. Gyöngyi Zoltán

22 GMO production for commercial use

Dr. Gyöngyi Zoltán

23 The economic impact of GMOs

Dr. Gyöngyi Zoltán

24 Social debates, publicity

Dr. Gyöngyi Zoltán

Practices

Seminars

Exam topics/questions

A GMO fogalma

A GMO megjelenésének igénye különböző tudományterületeken

A mezőgazdaság fejlődése a GMO megjelenéséig

A GM szervezetek szerepe a növénytermesztésben

A GM szervezetek szerepe az állattenyésztésben

A GM növények hatása természetes élőhelyekre és a biogazdálkodásra

GMO előállítás. Tudománytörténeti áttekintés

GMO előállítás. Biotechnológiai módszerek ismertetése

GMO kimutatási módszerek

A GM szervezetek élelmiszerekben való előfordulása, kimutathatóságuk

GMO az iparban

GMO a gyógyszeriparban

GMO a tudományban

GMO és a betegségmegelőzés

GMO és a gyógyítás

A génterápia múltja, jelene és jövője

Az ember genetikai módosítása

A GM szervezetek lehetséges egészségkárosító hatásai

GM szervezetek okozta halálesetek háttere

A GM szervezetek egészségkárosító hatásának kivédése

A GM szervezetek engedélyezésének feltételei

Kereskedelmi GMO előállítás

A GM szervezetek gazdasági hatása

Társadalmi viták, tájékoztatás

Participants

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OPF-H1B-T MEDICAL HUNGARIAN 1B - LANGUAGE POINTS

Course director: DR. VILMOS WARTA, associate professor

Department of Languages for Specific Purposes [email protected]

2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 1

Number of hours/semester: 0 lectures + 0 practices + 24 seminars = total of 24 hours

Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPF-H1A-T parallel

Topic

Familiarizing foreign students with basic paradigms used in specific conversations.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Written midterm and end of the term tests are compulsory. Other short written tests to be discussed with the course tutor in each individual

case. Several oral tests are taken, dates are to be discussed with the course tutor. Make up tests possible only during the semester classes.

Making up for missed classes

Participation in class work is obligatory. In case absences exceed 25% of total class time, the course will be regarded as uncompleted. In

the case of absences up to 25% of total class time, oral examination will have to be taken

Reading material

- Obligatory literature

Anamnézis magyarul (Magyar orvosi szaknyelv kezdőknek) by Renáta Halász, 2015. Pécs

- Literature developed by the Department

http://aok.pte.hu/index.php?page=egyseg&egy_id=60&menu=okt_anyag&nyelv=eng

- Notes

In-house course book: at the homepage of the institute:

http://aok.pte.hu/index.php?page=egyseg&egy_id=60&menu=okt_anyag&nyelv=eng

- Recommended literature

http://aok.pte.hu/index.php?page=egyseg&egy_id=60&menu=okt_anyag&nyelv=eng

Lectures

Practices

Seminars

1 Basics of Hungarian Phonetics and Morphology

2 Basics of Hungarian Phonetics and Morphology

3 Personal Pronouns - formal and informal style

4 Personal Pronouns - formal and informal style

5 Constructing Questions - Question Words

6 Constructing Questions - Question Words

7 Numerals - Cardinal, Ordinal, Labels

8 Numerals - Cardinal, Ordinal, Labels

9 Verbs - Definite and Indefinite Conjugation

10 Verbs - Definite and Indefinite Conjugation

11 Expressing Frequency

12 Expressing Frequency

13 Test 1

14 Articles

15 Modality - necessity

16 Modality - necessity

17 Objective Case

18 Verbal prefixes

19 Expressing Time

20 Expressing Time

21 Expressing Location - Trinity of Directions

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22 Dative Case

23 Test 2

24 Course Evaluation

Exam topics/questions

http://aok.pte.hu/index.php?page=egyseg&egy_id=60&menu=okt_anyag&nyelv=eng

Participants

Dávidovics Anna (U5A10Z), Dr. Hegedűs Anita (TQQEMK), Dr. Hild Gabriella (HILSWV), Dr. Németh Tímea (X8VRGN), Dr. Rébék-

Nagy Gábor (DGOZG1), Dr. Warta Vilmos (SJYRAV), Eklicsné Dr. Lepenye Katalin (JMXXSC), Krommer Zoltán (MQ5HNA),

Kurdiné Molnár Eszter (VUCECC), Nagy Gabriella (CYMRX3), Nagy Renáta (), Ronczykné Berta Anikó (CJZOFU), Szalai-Szolcsányi

Judit (RBGAPH), Szántóné Dr. Csongor Alexandra (UDKY0J)

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OPF-OTT-T HISTORY OF MEDICINE

Course director: DR. CSILLA RÚZSÁS, associate professor

Department of Operational Medicine [email protected]

2 credit ▪ midsemester grade ▪ Optional subject ▪ both semesters ▪ recommended semester: 1

Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours

Course headcount limitations (min.-max.): 5 – 80 Prerequisites: none

Topic

The purpose of the course is to give an opportunity for reviewing the progress in medicine historically, from the ancient times up to the

present époque, on the basis of cultural background. The understanding of the fact that the contemporary medicine is the result of the

efforts of several centuries will be hopefully stimulatory for the students in the professional improvement, realizing that both the

theoretical basis and healing practice are due to the devoted work of previous generations. Accordingly, the progress from healing art to

healing science will be illustrated in relation to the culture of previous centuries.

Since the students of our University come from countries of different cultures and traditions, the progress in medicine of ancient Greek

and Persian and Islamic culture are equally reviewed, besides the European medicine where English and German relations are of

outstanding importance, as reflected by the fact that in German universities, high number of weekly hours are devoted for the history of

medicine. Accordingly, the most outstanding physicians and clinical schools, playing a prominent role in the European progress will be

reviewed.

Our aim is to demonstrate that each culture represents a value which contributes to the common treasure of humanity.

Conditions for acceptance of the semester

Survey of the theoretical basis of medical practice in a historical period.

Mid-term exams

Making up for missed classes

Reading material

- Obligatory literature

- Literature developed by the Department

Summary of the content of each lecture (detailed description of authors and the main outlines of their activity promoting the medicine)

- Notes

- Recommended literature

Delano: The Story of Medicine, London

Benke J.: Az orvostudomány története - Hungarian ed. with English summary, Medicina, Bp. 2008.

Lectures

1 Archaic medicine

Dr. Rúzsás Csilla

2 Ancient Egypt, Mesopotamia, India, traditional Chinese medicine

Dr. Rúzsás Csilla

3 Medicine in Greece in the Antiquity

Dr. Rúzsás Csilla

4 The most outstanding medical schools; Hippocratic medicine

Dr. Rúzsás Csilla

5 Medicine in the Roman times. Galen.

Dr. Rúzsás Csilla

6 Byzantine leading doctors

Dr. Rúzsás Csilla

7 Early medieval medicine in Europe

Dr. Rúzsás Csilla

8 Monasteric medicine in medieval Europe

Dr. Rúzsás Csilla

9 The medicine under Islam

Dr. Rúzsás Csilla

10 The most outstanding physicians of Arabic-Islamic medicine

Dr. Rúzsás Csilla

11 Foundation of the universities in the Middle-Age

Dr. Rúzsás Csilla

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12 Scholastic medicine

Dr. Rúzsás Csilla

13 Medicine in the Renaissance

Dr. Rúzsás Csilla

14 Vesal. Paracelsus.

Dr. Rúzsás Csilla

15 Medicine of the 17th century: the golden age of sciences

Dr. Rúzsás Csilla

16 Raise of natural sciences. Iatrophysics and iatrochemistry

Dr. Rúzsás Csilla

17 The age of the 18th century

Dr. Rúzsás Csilla

18 The age of enlightment. Progress in pathology.

Dr. Rúzsás Csilla

19 Beginnings of modern medicine in the 19th century

Dr. Rúzsás Csilla

20 Medical schools in Europe

Dr. Rúzsás Csilla

21 Specialisation in medicine in the 19th century

Dr. Rúzsás Csilla

22 New approaches and equipment in medicine of the 19th century

Dr. Rúzsás Csilla

23 Medicine in the first half of the 20th century

Dr. Rúzsás Csilla

24 Main trends in medicine in the second half of the 20th century

Dr. Rúzsás Csilla

Practices

Seminars

Exam topics/questions

Possible themes for the essays:

Characteristics of the ancient Egyptian and Mesopotamian culture.

Medicine of ancestral Chinese civilization.

Medicine of Greece in the Antiquity.

Hippocratic medicine and the Hippocratic Collection.

Post-hippocratic medicine: The school of Athens and Alexandria.

Outstanding physicians of Persian and Arabic-Islamic medicine.

Medical education in the Middle-Ages.

The main epidemies in Europe.

The most prominent physicians in the Renaissance.

Main trends in medicine of the 19th century.

Ignatz Semmelweis, the saver of the mothers.

Most important discoveries in medicine in the 20th century.

Participants

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OPF-FEA-T BASICS OF INFECTIOUS DISEASE EPIDEMIOLOGY

Course director: DR. ISTVÁN ZOLTÁN KISS, professor

Department of Public Health Medicine [email protected]

1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 1

Number of hours/semester: 9 lectures + 3 practices + 0 seminars = total of 12 hours

Course headcount limitations (min.-max.): 5 – 15 Prerequisites: none

The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

However the morbidity and mortality caused by infectious diseases has significantly declined in the developed countries in the last

century due to the effective prevention methods, their complete elimination is not possible, infectious diseases are still part of our

everyday life. The spread of infectious diseases could be controlled by timely identification, proper investigation and by targeted

interventions. Aim of the course is to present the special characteristics of infectious diseases, and of infectious disease epidemiology;

basics and functioning of surveillance systems, the basics and steps of an outbreak investigation, and epidemiological methods used

during the investigation.

Conditions for acceptance of the semester

The participation in the lectures, seminars, practises is obligatory (a catalogue should be signed), a maximum of 2x45 min absence is

acceptable, above the signature will be rejected.

Mid-term exams

Making up for missed classes

None

Reading material

- Obligatory literature

- Literature developed by the Department

- Notes

- Recommended literature

Heymann (ed.): Control of Communicable Diseases Manual

Mikanatha, Lynfield, Van Beneden, de Valk (eds.): Infectious Disease Surveillance

Lectures

1 Special characteristics of infectious diseases

Dr. Prantner Ida

2 Basics of infectious disease epidemiology I

Dr. Prantner Ida

3 Basics of infectious disease epidemiology II

Dr. Prantner Ida

4 Methods used in infectious disease epidemiology

Dr. Prantner Ida

5 Basic principles of surveillance

Dr. Prantner Ida

6 Infectious disease surveillance

Dr. Prantner Ida

7 Basics and steps of outbreak investigation I

Dr. Prantner Ida

8 Basics and steps of outbreak investigation II

Dr. Prantner Ida

9 Investigation of a food-borne outbreak

Dr. Prantner Ida

Practices

1 Use of epidemiological knowledge in practice I (definitions, surveillance data interpretation, analysis)

2 Use of epidemiological knowledge in practice II (Data collection, analysis, graphical interpretations)

3 Use of epidemiological knowledge in practice III (analytic studies)

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Seminars

Exam topics/questions

Participants

Dr. Prantner Ida (WO4A8D)

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OPE-QAS-T QUANTITATIVE ANALYTICAL CHEMISTRY CALCULATION

Course director: DR. GYŐZŐ KORNÉL KULCSÁR, assistant professor

Department of Pharmaceutical Chemistry [email protected]

2 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ spring semester ▪ recommended semester: 2

Number of hours/semester: 0 lectures + 0 practices + 28 seminars = total of 28 hours

Course headcount limitations (min.-max.): 5 – 50 Prerequisites: none

Topic

The Quantitative analytical chemistry calculation course helps students to understand the analytical (titrimetric) calculations. It makes

theoretical backgrounds more understandable.

Conditions for acceptance of the semester

According to the Code of Studies and Examinations (see on the homepage). During the semester maximum 3 missed classes are

acceptable. Two midterm tests will be written during the semester. The result of both tests should be above 60%.

Mid-term exams

Two written exams during the semester.

Making up for missed classes

Missing written exams should be made up.

Reading material

- Obligatory literature

Harris D.C.: Quantitative Chemical Analysis, 8th ed., W.H. Freeman and Co., New York, 2010

- Literature developed by the Department

Handouts.

- Notes

- Recommended literature

Lectures

Practices

Seminars

1 Introduction - Concentrations - Concentration of standard solutions.

2 Introduction - Concentrations - Concentration of standard solutions.

3 Acid-base titrations - Methods for calculating the titration results. Calculations with molarity and normality.

4 Acid-base titrations - Methods for calculating the titration results. Calculations with molarity and normality.

5 Neutralization analysis - Standardization of a titrant. Titration curve calculations.

6 Neutralization analysis - Standardization of a titrant. Titration curve calculations.

7 Calculation of pH in titration problems I. Hydrolysis of salts.

8 Calculation of pH in titration problems I. Hydrolysis of salts.

9 Calculation of pH in titration problems II. Buffers.

10 Calculation of pH in titration problems II. Buffers.

11 Non-aqueous titration calculations.

12 Non-aqueous titration calculations.

13 Complexometry - Methods for calculating the titration results.

14 Complexometry - Methods for calculating the titration results

15 Complex chemical equilibria - Calculations with the stability constants.

16 Complex chemical equilibria - Calculations with the stability constants.

17 Redox titrations II. - Calculations based on oxidimetry.

18 Redox titrations II. - Calculations based on oxidimetry.

19 Redox titrations I. - Redox titration curve calculations.

20 Redox titrations I. - Redox titration curve calculations.

21 Redox titrations I. - Calculations based on oxidimetry.

22 Redox titrations I. - Calculations based on oxidimetry.

23 Redox titrations III. - Calculations based on reductometry.

24 Redox titrations III. - Calculations based on reductometry.

25 Precipitate formation titrations - Calculations for the solubility products.

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26 Precipitate formation titrations - Calculations for the solubility products.

27 Gravimetry.

28 Gravimetry.

Exam topics/questions

The final grade is established based on the average of each written exams.

Participants

Dr. Almási Attila (KJ5MBZ), Dr. Kulcsár Győző Kornél (R7V5ZT)

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UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020

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OPE-ABI-T APPLIED BIOMETRICS

Course director: DR. KORNÉLIA FARKAS-BORBÁS, assistant professor

Institute of Bioanalysis [email protected]

1 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ spring semester ▪ recommended semester: 2

Number of hours/semester: 6 lectures + 6 practices + 0 seminars = total of 12 hours

Course headcount limitations (min.-max.): 1 – 12 Prerequisites: none

Topic

Basics of biometrical methods are indispensable to understand the scientific results, to plan own research, and to evaluate data. The main

goal of the course is to expand and deepened the basic knowledge of biometrics via solving practical problems.

Object of the course is to demonstrate different type of research with most frequently applied biometrical methods, though representative

examples or with using of the data of the participants.

Conditions for acceptance of the semester

Problem solving, oral report

Mid-term exams

Short presentation(s) on the classes by the students

Making up for missed classes

Consultation

Reading material

- Obligatory literature

- Literature developed by the Department

- Notes

- Recommended literature

Andrew F. Siegel: Statistics and Data Analysis. An introduction, John Wiley & Sons, 1988

Douglas G. Altman: Practical Statistics for Medical Research, Chapman & Hall, 1994

P. Armitage and G. Berry: Statistical Methods in Medical Research, Blackwell Science, 1994

Robert R. Sokal / F. James Rohlf: Biometry, W. H. Freeman and Company, New York, 1981

Lectures

1 Introduction to research methodology, refresh the bio-statistical knowledge

Dr. Pótó László

2 Variance analysis

Borbásné Dr. Farkas Kornélia

3 Regression analysis

Dr. Pótó László

4 Correlation analysis

Borbásné Dr. Farkas Kornélia

5 Survival analysis

Borbásné Dr. Farkas Kornélia

6 Factor analysis

Borbásné Dr. Farkas Kornélia

Practices

1 Refresh the bio-statistical knowledge using the SPSS, exercises

2 Variance analysis, post-hoc tests

3 Linear and non-linear regression analysis

4 Parametric and non-parametric(rank-) correlation analysis

5 Survival analysis, Cox-regression analysis...

6 Factor analysis

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Seminars

Exam topics/questions

Participants

Borbásné Dr. Farkas Kornélia (IRWZKJ), Dr. Pótó László (FIO4UU)

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OPE-KP2-T BASICS OF CHEMISTRY 2

Course director: DR. PÁL PERJÉSI, professor

Department of Pharmaceutical Chemistry [email protected]

2 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ spring semester ▪ recommended semester: 2

Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours

Course headcount limitations (min.-max.): 5 – 50 Prerequisites: none

Topic

Based on the previously acquired high school knowledge the course provides an overview on the basic laws of Chemistry concentrating

on those that are ubiquitous in the chemistry-related subjects of the basic modules of the health related curriculums. The course helps

understanding the chemistry-related compulsory subjects of the modules.

Conditions for acceptance of the semester

Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation in the lectures is obligatory.

Maximum three absences can be accepted both from lectures and practices. Two midterm tests will be written during the semester on the

7th and the 12th weeks. The result of both tests should be above 60%. One re-take chance is allowed after both tests.

Mid-term exams

Making up for missed classes

There is no opportunity to make up missed classes.

Reading material

- Obligatory literature

Ebbing D.D., Gammon S.D.: General Chemistry, Houghton Miffilin Co., Boston, 2009

- Literature developed by the Department

Almási A., Kuzma M., Perjési P.: General and Inorganic Chemistry - Laboratory Techniques and Practices, electronic educational

material University of Pécs, 2014

- Notes

- Recommended literature

en.wikibooks.org/wiki/General_Chemistry

J. McMurray, R. C. Fay: Chemistry, 5th edition

Lectures

1 The electronic structure of atom. Periodic properties.

Dr. Perjési Pál

2 The electronic structure of atom. Periodic properties.

Dr. Perjési Pál

3 Structure of molecules. The valence bond theory

Dr. Perjési Pál

4 Structure of molecules. The valence bond theory

Dr. Perjési Pál

5 Structure of molecules. The molecular-orbital theory.

Dr. Perjési Pál

6 Structure of molecules. The molecular-orbital theory.

Dr. Perjési Pál

7 Bonding in solids

Dr. Perjési Pál

8 Bonding in solids

Dr. Perjési Pál

9 Molecular spectroscopy I. UV-VIS

Dr. Perjési Pál

10 Molecular spectroscopy I. UV-VIS

Dr. Perjési Pál

11 Carbon: structure and reactivity

Dr. Perjési Pál

12 Carbon: structure and reactivity

Dr. Perjési Pál

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13 Nitrogen: structure and reactivity.

Dr. Perjési Pál

14 Nitrogen: structure and reactivity.

Dr. Perjési Pál

15 Oxygen: structure and reactivity.

Dr. Perjési Pál

16 Oxygen: structure and reactivity.

Dr. Perjési Pál

17 Transition metals: structure and reactivity

Dr. Perjési Pál

18 Transition metals: structure and reactivity

Dr. Perjési Pál

19 Coordination compounds I. Metal-ligand bonding I

Dr. Perjési Pál

20 Coordination compounds I. Metal-ligand bonding I

Dr. Perjési Pál

21 Coordination compounds II. Metal-ligand bonding II

Dr. Perjési Pál

22 Coordination compounds II. Metal-ligand bonding II

Dr. Perjési Pál

23 Coordination compounds III. Isomerism

Dr. Perjési Pál

24 Coordination compounds III. Isomerism

Dr. Perjési Pál

25 Coordination compounds IV. Stability.

Dr. Perjési Pál

26 Coordination compounds IV. Stability.

Dr. Perjési Pál

27 Basic photochemistry

Dr. Perjési Pál

28 Basic photochemistry

Dr. Perjési Pál

Practices

Seminars

Exam topics/questions

Written test covering the topics of the lectures.

Participants

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OPE-FKS-T PHYSICAL CHEMISTRY PROBLEM SOLVING SEMINAR

Course director: DR. LÍVIA NAGY-ZENGŐ, senior research fellow

Faculty of Natural Sciences - Department of General and Physical Chemistry [email protected]

1 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ spring semester ▪ recommended semester: 2

Number of hours/semester: 0 lectures + 0 practices + 14 seminars = total of 14 hours

Course headcount limitations (min.-max.): 3 – 36 Prerequisites: OPA-PC1-T parallel

Topic

This is an elective course, a lecture room practice. It helps the student understanding the ways of calculating quantitative properties of

material, extent of changes and determine important physicochemical parameters. It shows the applicability of the theoretical forms, the

proper using of units in calculations. Showing the applicability of theory it supports bringing close to understanding the principles of

basic course on physical chemistry. The practice is an informal discussion following the physical chemistry I lecturing. The students

obtain problems to solve as home work. These problems are discussed during the practice. During the semester written test are given.

The evaluation is based on the scores. Students taking this course usually can solve easier the calculating problems at the physical

chemistry I course.

Conditions for acceptance of the semester

One class absence can be tolerated.

Mid-term exams

Making up for missed classes

Full solved problems will be handed over in written form for the absent student.

Reading material

- Obligatory literature

P. Atkins, J. de Paula: Physical Chemistry, 8th edition, Oxford University Press 2006, ISBN 9780198700722

- Literature developed by the Department

- Notes

- Recommended literature

P. Atkins, J. de Paula: Physical Chemistry, 8th edition, Oxford University Press 2006, ISBN 9780198700722

D. Freifelder: Physical Chemistry for Students of Biology and Chemistry, Science Books International Inc. ISBN 0 86720-002-2

Lectures

Practices

Seminars

1 The properties of gases: states of perfect gas, the gas laws, units.

2 Basic concepts in thermodynamics, expansion work, internal energy of a system. Application of the first law.

3 Calculation of enthalpy and calorimetry.

4 Calculation of formation enthalpy and the heat capacity (cp, cv).

5 Calculation of the changes in internal energy.

6 Problem solving of entropy, changing of entropy in different processes.

7 Test: the gas laws, the first law, change in internal energy of a system, the heat capacities and entropy

8 Problems of the kinetic model of gases, collision with walls and surfaces.

9 Calculation: First rate chemical reactions.

10 Calculation: First rate chemical reactions, determination of ages by reaction kinetic base.

11 Problem solving of second rate chemical reaction and enzyme reaction

12 Electrochemical calculations: Faraday”s laws, conductivity in electrolytes, Nernst equation, Galvan cells

13 Test: problems fom kinetic model of gases, reaction kinetics and Faraday”s laws.

14 Calculation of electrolysis and corrosion

Exam topics/questions

The solved problems will be handed over in written form for the students at the end of the semester.

Participants

Dr. Nagyné Dr. Zengő Lívia (EOQ0QG)

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OPE-DRD-T DRUG DESIGN

Course director: DR. CSABA HETÉNYI, associate professor

Department of Pharmacology and Pharmacotherapy [email protected]

2 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ spring semester ▪ recommended semester: 2

Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours

Course headcount limitations (min.-max.): 1 – 300 Prerequisites: none

Topic

The course offers an overview of the whole process of drug design between selection of the disease and marketing of the drug. The

introductory lectures are followed by detailed reviews of certain phases of drug design including prediction of both drug action and

pharmacokinetic properties. In this regard, theoretical and experimental methods of drug design will be also introduced. Case studies will

demonstrate successful examples and also difficulties arising during the design process. Students with a researcher attitude are primary

targets of this course. Besides them, the course provides useful knowledge for future medical doctors and pharmacists as it explains the

complex process of drug discovery in a comprehensible way. This hopefully helps the students navigating in the jungle of laws of

pharmacology also used in molecular design. Furthermore, the course deals with the problems of prediction of toxicity and side-effects,

and discusses certain questions of production and legalization process of new drugs, as well. In Journal Club sessions, recent research

articles will be featured with the students to deepen their knowledge in the areas discussed during the previous lectures. In this way, the

students can discover further connections themselves and make sure of the usefulness of their newly obtained knowledge in drug design.

Conditions for acceptance of the semester

Jelenleg a választható és elektív kurzusok esetén a szabályzat nem tartalmaz részvételi követelményt. Amennyiben szükséges itt valamit

megjelölnöm, akkor 25 %, de csak azért teszem, hogy kitölthető legyen az űrlap. Javasoltam a Tanulmányi Bizottság vezetőjének a

helyzet szabályzását és 50 % mértéket a hiányzásoknál.

Mid-term exams

There is a final test announced at the end of the semester. The test will include multiple choice questions and short essays. A mark is

offered according to the results of the written test and optionally by evaluation of the student’s presentation prepared for the Journal

Club. The student can improve the mark according to university regulations.

Making up for missed classes

Replacement is possible according to personal consultation.

Reading material

- Obligatory literature

- Literature developed by the Department

The material of the course including pdfs of lectures and lists of questions will be made downloadable from the web site of the

Department of Pharmacology and Pharmacotherapy or a link will be provided during the lectures / in an e-mail.

- Notes

- Recommended literature

Patrick GL: An Introduction to Medicinal Chemistry, Oxford University Press

Lectures

1 Selection of the disease. Goals, terminology, trends.

Dr. Hetényi Csaba

2 Conditions. Strategies. Ligand-based design.

Dr. Hetényi Csaba

3 Traditional design.

Dr. Hetényi Csaba

4 Target-based drug design.

Dr. Hetényi Csaba

5 Target selection and validation.

Dr. Hetényi Csaba

6 Protein targets 1. General overview, structural proteins.

Dr. Hetényi Csaba

7 Protein targets 2. Enzymes and receptors.

Dr. Hetényi Csaba

8 Experimental structure determination methods.

Dr. Hetényi Csaba

9 Theoretical structure determination methods.

Dr. Hetényi Csaba

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10 Lipids and nucleic acids as targets.

Dr. Hetényi Csaba

11 Journal club 1. Comparison of strategies. Evaluation of targets.

Dr. Hetényi Csaba

12 Journal club 2. X-ray crystallography and NMR. Cryo-electronmicroscopy.

Dr. Hetényi Csaba

13 Experimental methods of lead selection and design.

Dr. Hetényi Csaba

14 Molecular complexes of leads. Thermodynamic and kinetic stability.

Dr. Hetényi Csaba

15 Theoretical methods of lead selection and design.

Dr. Hetényi Csaba

16 Lead optimizations, transformations.

Dr. Hetényi Csaba

17 ADMETox optimization 1. Goals, general description.

Dr. Hetényi Csaba

18 ADMETox optimization 2. Methods.

Dr. Hetényi Csaba

19 Termination of design. Production and development.

Dr. Hetényi Csaba

20 Side-effects and postmarketing surveillance.

Dr. Hetényi Csaba

21 Case study 1. The design of antiviral drugs.

Dr. Hetényi Csaba

22 Case study 2. The design of anti-cancer drugs.

Dr. Hetényi Csaba

23 Journal club 3. Development of new methods. Paradigm shifts of drug design.

Dr. Hetényi Csaba

24 Journal club 4. Molecular dynamics. Docking.

Dr. Hetényi Csaba

Practices

Seminars

Exam topics/questions

Lists of questions will be provided at the end of each lecture specifying the required knowledge.

Participants

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UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020

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OPE-ETI-T PHARMACY ETHICS

Course director: TIBOR SZOLCSÁNYI, assistant professor

Department of Behavioural Sciences [email protected]

1 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ spring semester ▪ recommended semester: 2

Number of hours/semester: 0 lectures + 0 practices + 12 seminars = total of 12 hours

Course headcount limitations (min.-max.): 5 – 25 Prerequisites: none

Topic

The aim of the course is to help students gain sensitivity to the ethical issues connected to the pharmacy practice. During the course

students learn about the basic ethical principles governing the pharmacist-patient and the pharmacist-physician relationship. Students

also get acquainted with the dilemmas that are raised by the conflict between business and ethics in pharmacy. The most important

concerns of research ethics and some specific ethical issues, like the question of mind-enhancing drugs, are also discussed during the

course.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Written test taking place in the last class. To improve the grade, the test can be repeated two times in the first two weeks of the exam

period. Oral exam is also an option for that purpose.

Making up for missed classes

According to the Code of Studies and Examinations

Reading material

- Obligatory literature

--

- Literature developed by the Department

Additional materials: Neptun MeetStreet

- Notes

--

- Recommended literature

Robert Veatch and Amy Haddad (eds.): Case Studies in Pharmacy Ethics, 2nd edition, Oxford University Press, New York, 2008

Lectures

Practices

Seminars

1 Introduction

2 A short history of pharmacy

3 General ethical viewpoints

4 The principle of informed consent in modern health-care

5 The ethics of patient-pharmacist relationship

6 The ethics of physician-pharmacist relationship

7 The conflict between business and ethics in pharmacy

8 The placebo effect and its ethical concerns

9 Dietary supplements, performance- and mind- enhancing drugs

10 Ethical issues in clinical drug trials

11 Summarizing discussion

12 Test

Exam topics/questions

--

Participants

Dr. Szolcsányi Tibor (HNQ526)

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UP FP Pharmacy major – Elective and Optional subjects - Course descriptions – academic year of 2019/2020

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OPE-GKT-T HISTORY OF MANUFACTURE OF MEDICINES

Course director: DR. SZILÁRD PÁL, assistant professor

Institute of Pharmaceutical Technology and Biopharmacy [email protected]

2 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ spring semester ▪ recommended semester: 2

Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours

Course headcount limitations (min.-max.): 5 – 100 Prerequisites: none

Topic

Aim of the course is to explain the importance of the birth of Pharmaceutical Technology, introducing the manufacture of medicines

from the ancient times until the new age. Lectures will explain how first medicines were made, how the first pharmaceutical technological

equipments were created and how the mass production of drugs became more and more important. Lectures will also elaborate the birth

of famous medicines, like the quinine, aspirin, insulin and the sildenafil.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

- participation on the lectures

- accepted work reports

- accepted written assessments

Students have to write an end-semester assessment from the lectures at acceptance level of 60%.

Making up for missed classes

Students must fulfil requirements determined by the Code of Studies and Examinations. Student has make up for the missed lectures and

work reports.

Reading material

- Obligatory literature

- Literature developed by the Department

- Notes

- Recommended literature

Leon Shargel, A. B.C. Yu, Stamford: Applied Biopharmaceutics and Pharmacokinetics

Susanna Wu-Pong, Yon Rojanasakul: Biopharmaceutical Drug Design and Development, Humana Press

Gilbert S. Banker, Christopher T. Rhodes: Modern Pharmaceutics, Marcel Dekker Inc., New York- Basel

Michael J. Rathbone, Michael S. Roberts: Modified-Release Drug Delivery Technology, Informa Healthcare

Michael E. Aulton: The Design and Manufacture of Medicines, Churchill Livingstone

Lectures

1 Introduction

Dr. Pál Szilárd

2 introduction

Dr. Kása Péter

3 Ancient technologies (Egypt, Greece, Persian Empire)

Dr. Pál Szilárd

4 Ancient technologies (Egypt, Greece, Persian Empire)

Dr. Kása Péter

5 Influence of alchemy to the pharmaceutical technology

Dr. Pál Szilárd

6 Influence of alchemy to the pharmaceutical technology

Dr. Kása Péter

7 Middle ages

Dr. Pál Szilárd

8 Middle ages

Dr. Kása Péter

9 Effect of industrial revolution

Dr. Pál Szilárd

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10 Effect of industrial revolution

Dr. Kása Péter

11 Development of medicines in the new age

Dr. Pál Szilárd

12 Development of medicines in the new age

Dr. Kása Péter

13 Birth of the first industrial manufacturers

Dr. Pál Szilárd

14 Birth of the first industrial manufacturers

Dr. Kása Péter

15 Evolution of community pharmacies

Dr. Pál Szilárd

16 Evolution of community pharmacies

Dr. Kása Péter

17 Drugs that changed the world

Dr. Pál Szilárd

18 Drugs that changed the world

Dr. Kása Péter

19 Invention of the quinine

Dr. Pál Szilárd

20 Invention of the aspirine

Dr. Kása Péter

21 Invention of various famous drugs

Dr. Pál Szilárd

22 Invention of the sildenafil

Dr. Kása Péter

23 Invention of the insulin

Dr. Pál Szilárd

24 Invention of the insulin

Dr. Kása Péter

25 Test

Dr. Pál Szilárd

26 Test

Dr. Kása Péter

27 Attending the Saracen Pharmacy in Pécs

Dr. Pál Szilárd

28 Attending the Saracen Pharmacy in Pécs

Dr. Kása Péter

Practices

Seminars

Exam topics/questions

Students can get the test topics in the institute or download the from website of the institute.

Participants

Dr. Kása Péter (ISWPRM), Dr. Pál Szilárd (FYF5E9)

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OPE-JEA-T DISEASES OF SIGNAL TRANSDUCTION

Course director: GYÖRGY SÉTÁLÓ DR., associate professor

Department of Medical Biology and Central Electron Microscope Laboratory [email protected]

1 credit ▪ midsemester grade ▪ Elective subject for the Medical-biological module ▪ spring semester ▪ recommended semester: 2

Number of hours/semester: 12 lectures + 0 practices + 0 seminars = total of 12 hours

Course headcount limitations (min.-max.): 5 – 25 Prerequisites: OPO-GL1-T completed + OPO-G2B-T parallel

The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

The topics of signal transduction will be discussed beyond the details of the compulsory course, Molecular cell biology 2. In 14 x 45

minutes special attention is paid to mechanisms that are relevant to diseases.

The course is recommended to those students who are especially interested in the signaling aspects of pathological processes.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Two multiple-choice test-exams, with 20-25 questions each, one halfway and another one at the end of the course.

Making up for missed classes

It is not possible to make up for missed classes.

Reading material

- Obligatory literature

- Literature developed by the Department

Lecturers using ppt will load these up onto the intranet after their class.

- Notes

- Recommended literature

Lectures

1 The protein kinase A system.

Dr. Sétáló György

2 Signaling in infectious diseases (cholera, pertussis and anthrax).

Dr. Palkovics Tamás

3 Growth factor signaling.

Dr. Sétáló György

4 Signaling through cell-cell and cell-matrix connections.

Dr. Sétáló György

5 First test.

Dr. Sétáló György

6 Stress signaling.

Dr. Bátor Judit

7 Signaling and inflammation.

Dr. Mikó Éva

8 Signaling of apoptosis.

Dr. Pap Marianna

9 Steroid signaling.

Dr. Sétáló György

10 Integrin signaling and metastasis.

Dr. Berta Gergely

11 Signaling gone wrong in the developing nervous system.

Dr. Ábrahám Hajnalka Gabriella

12 Second test.

Dr. Sétáló György

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Practices

Seminars

Exam topics/questions

Multiple-choice test questions based on the actually presented materials of the course.

Participants

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OPF-H2A-T MEDICAL HUNGARIAN 2A - COMMUNICATION SKILLS

Course director: DR. VILMOS WARTA, associate professor

Department of Languages for Specific Purposes [email protected]

2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 2

Number of hours/semester: 0 lectures + 0 practices + 24 seminars = total of 24 hours

Course headcount limitations (min.-max.): 2 – 25 Prerequisites: OPF-H1A-T completed + OPF-H2B-T parallel

Topic

This course is meant to serve as a transition between general and specific (doctor-patient) communication skills development.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Making up for missed classes

In the case of absences up to 25% of total class time, oral examination will have to be taken.

Reading material

- Obligatory literature

Anamnézis magyarul (Magyar orvosi szaknyelv kezdőknek) by Renáta Halász, 2015. Pécs

- Literature developed by the Department

http://aok.pte.hu/index.php?page=egyseg&egy_id=60&nyelv=eng&menu=okt_anyag

- Notes

http://aok.pte.hu/index.php?page=egyseg&egy_id=60&menu=okt_anyag&nyelv=eng

- Recommended literature

Lectures

Practices

Seminars

1 Logical relations, comparison

2 Logical relations, comparison

3 Giving orientation, informing people

4 Giving orientation, informing people

5 Giving descriptions, requesting and providing information

6 Giving descriptions, requesting and providing information

7 Cause and consequence

8 Medication and effects

9 Narratives

10 Narratives

11 Giving advice

12 Giving advice

13 Expressing uncertainty

14 Expressing uncertainty

15 Test 1

16 Test 1

17 Descriptions, warning

18 Descriptions, warning

19 Polite request, command and warning

20 Polite request, command and warning

21 Parts of the human body, pain, basic symptoms

22 Parts of the human body, pain, basic symptoms

23 History taking: presenting complaints, location, direction and character of pain

24 Test 2.

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Exam topics/questions

http://aok.pte.hu/index.php?page=egyseg&egy_id=60&menu=okt_anyag&nyelv=eng

Participants

Dávidovics Anna (U5A10Z), Dr. Hegedűs Anita (TQQEMK), Dr. Hild Gabriella (HILSWV), Dr. Németh Tímea (X8VRGN), Dr. Rébék-

Nagy Gábor (DGOZG1), Dr. Warta Vilmos (SJYRAV), Eklicsné Dr. Lepenye Katalin (JMXXSC), Krommer Zoltán (MQ5HNA),

Kurdiné Molnár Eszter (VUCECC), Nagy Gabriella (CYMRX3), Nagy Renáta (), Ronczykné Berta Anikó (CJZOFU), Szalai-Szolcsányi

Judit (RBGAPH), Szántóné Dr. Csongor Alexandra (UDKY0J)

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OPF-IZM-T MOLECULAR BASIS OF MUSCLE FUNCTION

Course director: DR. DÉNES LŐRINCZY, professor emeritus

Department of Biophysics [email protected]

2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 2

Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours

Course headcount limitations (min.-max.): 1 – 30 Prerequisites: none

Topic

The structure of muscle based on light, phase contrast, polarized and electron microscopic observations. Elastic behaviour of passive and

active muscle, types of muscle contractions, muscle force-length relationship. Work done by the muscle, muscle efficiency and heat

production. Thermoelastic behaviour of muscle. Muscle models based on mechanical and structural investigations. Bioelectrical

phenomena, excitation-contraction coupling. Energetics of muscle function, structure of muscle proteins (actin, myosin etc.), analysis of

sliding model. Energetic and spectroscopic investigations in the research of molecular dynamic and thermodynamic background of

muscle function.

Conditions for acceptance of the semester

The applicants - in the case of more than one absence (up to maximum three absences in which must not be the consultation or test) -

should prepare and will be tested from the missed topics given by the instructor. In the case of more than three absences the course can

not be accepted.

Mid-term exams

Written test at the end of semester.

Making up for missed classes

The applicants - in the case of more than one absence (up to maximum three absences in which must not be the consultation or test) -

should prepare and will be tested from the missed topics given by the instructor.

Reading material

- Obligatory literature

- Literature developed by the Department

It will be announced at the beginning of the course depending on the possibilities of libraries of Biophysical Department, Faculty of

Medicine. A permanent source could be the roaming in the Internet.

- Notes

- Recommended literature

Lectures

1 The composition of muscle.

Dr. Lőrinczy Dénes

2 The sorts of muscle.

Dr. Lőrinczy Dénes

3 The structure of muscle on the basis of light, phasecontrast and polarization microscope.

Dr. Lőrinczy Dénes

4 Structure of muscle by ELMI.

Dr. Lőrinczy Dénes

5 Sorts of muscle contraction.

Dr. Lőrinczy Dénes

6 Elastic behaviour of passive and active muscle.

Dr. Lőrinczy Dénes

7 Muscle force and length relationship, Hill`s equation.

Dr. Lőrinczy Dénes

8 Work and heat production done by a muscle, efficiency of muscle function.

Dr. Lőrinczy Dénes

9 Thermoelastic behaviour of muscle.

Dr. Lőrinczy Dénes

10 Muscle models proposed by mechanical and structural investigations.

Dr. Lőrinczy Dénes

11 Biochemical basis and energetics of muscle function.

Dr. Lőrinczy Dénes

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12 Bioelectrical phenomena. Action potentials.

Dr. Lőrinczy Dénes

13 Nernst equation, G-H-K equation.

Dr. Lőrinczy Dénes

14 Voltage- and patch-clamp techniques.

Dr. Lőrinczy Dénes

15 Excitation-contraction coupling.

Dr. Lőrinczy Dénes

16 Structure of muscle proteins (actin and myosin, actomyosin complex).

Dr. Lőrinczy Dénes

17 Discussion of sliding model in details (x-ray diffraction).

Dr. Lőrinczy Dénes

18 Molecular dynamic background of muscle contraction (EPR spectroscopy)

Dr. Lőrinczy Dénes

19 Muscle in the sport and rehabilitation (wellness).

Dr. Lőrinczy Dénes

20 Principle of differential scanning calorimetry.

Dr. Lőrinczy Dénes

21 Thermodynamic background of muscle contraction (DSC results)

Dr. Lőrinczy Dénes

22 Muscle and levers in locomotion.

Dr. Lőrinczy Dénes

23 Written test.

Dr. Lőrinczy Dénes

24 Written test.

Dr. Lőrinczy Dénes

Practices

Seminars

Exam topics/questions

Written test

Participants

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OPF-XC1-T EXTRACELLULAR VESICLES: BASICS, ISOLATION AND APPLICATION METHODS 1

Course director: DR. KRISZTIÁN KVELL, associate professor

Department of Pharmaceutical Biotechnology [email protected]

2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 2

Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours

Course headcount limitations (min.-max.): 5 – 20 Prerequisites: OPO-GL1-T completed

Topic

The course provides basic knowledge of different subtypes of extracellular vesicles. It gives a historical overview and detailed role in

physiological processes. Also covers the content and major components of extracellular vesicles. Besides overall theoretical background

of the field, the course gives ability to understand the challenges in different kind of isolation methods. Gives insight into current

application methodologies and future perspectives in the research field. Also highlights several possible molecular mechanisms

modulated by exosomes. The second part of the course mainly focuses on exosomes and their practical applications.

Topics:

- Basics of extracellular vesicles

- History of extracellular vesicles

- Biogenesis and release of extracellular vesicles

- Mechanisms of extracellular vesicle uptake

- Protein content of extracellular vesicles

- RNA content of extracellular vesicles

- Lipid content of extracellular vesicles

- Isolation methods for extracellular vesicles (overview)

- Technical challenges of working with extracellular vesicles

- Exosome isolation techniques from cell culture media

- Isolation of exosomes with differential ultracentrifugation

- Exosome isolation from blood plasma and serum

- Commercial kit based isolation of exosomes

- Minimal requirements for characterization of isolated extracellular vesicles

- Current trends in EV research

- Role of exosomes during aging

- Role of exosomes during tumor development

- Exercise derived exosomes

- Exam

Skills:

The student will have the following skills:

- basic and overall knowledge of extracellular vesicles

- apply different type of isolation methods of extracellular vesicles

- comprehend/resolve pitfalls and challenges of purification and isolation of extracellular vesicles

- apply extracellular vesicle point of view on research field of interest

- plan experiments in research field of interest

- get familiar with current research areas related to extracellular vesicles

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Grade based on written tests of semester

Making up for missed classes

Attending the course classes is obligatory.

Reading material

- Obligatory literature

Winston Patrick Kuo, Shidong Jia: Extracellular Vesicles: Methods and Protocols, Springer New York, 2017, ISBN 1493972510,

9781493972517

- Literature developed by the Department

Lecture materials will be published after the class

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- Notes

Student notes on lectures

- Recommended literature

Ramirez, M. I., Amorim, M. G., Gadelha, C., Milic, I., Welsh, J. A., Freitas, V. M., et al. (2018). Technical challenges of working

with extracellular vesiclesvesicles. Nanoscale. 881-906. doi:10.1039/c7nr08360b.

Lectures

1 Basics of extracellular vesicles

Bánfai Krisztina

2 History of extracellular vesicles

Bánfai Krisztina

3 Biogenesis and release of extracellular vesicles

Garai Kitti

4 Mechanisms of extracellular vesicle uptake

Garai Kitti

5 Protein content of extracellular vesicles I.

Bánfai Krisztina

6 Protein content of extracellular vesicles II.

Bánfai Krisztina

7 RNA content of extracellular vesicles I.

Garai Kitti

8 RNA content of extracellular vesicles II.

Garai Kitti

9 Lipid content of extracellular vesicles I.

Bánfai Krisztina

10 Lipid content of extracellular vesicles II.

Bánfai Krisztina

11 Isolation methods for extracellular vesicles (overview)

Garai Kitti

12 Technical challenges of working with extracellular vesicles

Garai Kitti

13 Exosome isolation techniques from cell culture media

Bánfai Krisztina

14 Isolation of exosomes with differential ultracentrifugation

Bánfai Krisztina

15 Exosome isolation from blood plasma and serum

Garai Kitti

16 Commercial kit based isolation of exosomes

Garai Kitti

17 Minimal requirements for characterization of isolated extracellular vesicles I.

Garai Kitti

18 Minimal requirements for characterization of isolated extracellular vesicles II.

Garai Kitti

19 Current trends in EV research I.

Bánfai Krisztina

20 Current trends in EV research II.

Bánfai Krisztina

21 Role of exosomes during aging I.

Dr. Kvell Krisztián

22 Role of exosomes during aging II.

Dr. Kvell Krisztián

23 Role of exosomes during tumor development I.

Dr. Pongrácz Judit Erzsébet

24 Role of exosomes during tumor development II.

Dr. Pongrácz Judit Erzsébet

25 Exercise derived exosomes I.

Dr. Kvell Krisztián

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26 Exercise derived exosomes II.

Dr. Kvell Krisztián

27 Exam

Bánfai Krisztina

28 Exam

Garai Kitti

Practices

Seminars

Exam topics/questions

At the last class oral test is held upon the exam questions provided during the semester.

Participants

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OPF-BMK-T METHODS AND EXPERIMENTS IN MOLECULAR BIOLOGY

Course director: DR. KATALIN SIPOS, associate professor

Department of Pharmaceutical Biology [email protected]

1 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 2

Number of hours/semester: 0 lectures + 0 practices + 14 seminars = total of 14 hours

Course headcount limitations (min.-max.): 5 – 25 Prerequisites: none

Topic

We will analyze famous and interesting molecular biological experiments and examine the development and everyday importance of

methods used in molecular biology. We will pay special attention for experimental areas of pharmaceutical research. We hope the course

material will help the students to develop problemsolving thinking.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

The course will end with a written exam.

Making up for missed classes

According to personal agreement

Reading material

- Obligatory literature

- Literature developed by the Department

Scientific articles in English

- Notes

- Recommended literature

Lectures

Practices

Seminars

1 Methods to follow replication.

2 Molecular biological methods of cell cycle examinations

3 PCR

4 Array methods

5 Blotting methods

6 Labeling methods in the molecular biology

7 Gene regulation in the prokaryotes

8 Gene regulation in the eukaryotes.

9 Genetically modified animals

10 Experimental planning in pharmaceutical research I.

11 Experimental planning in pharmaceutical research II.

12 Real time PCR

13 Methods in cell culture experiments

14 Exam

Exam topics/questions

No extra exam questions. The basis of the exam is the material of the seminars.

Participants

Dr. Pandur Edina (ZP0077), Dr. Poór Viktor Soma (SA17J1), Dr. Sipos Katalin (RUHPLE), Jánosa Gergely (U3SEOW), Pap Ramóna

(OGEM0W)

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OPF-H2B-T MEDICAL HUNGARIAN 2B - LANGUAGE POINTS

Course director: DR. VILMOS WARTA, associate professor

Department of Languages for Specific Purposes [email protected]

2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 2

Number of hours/semester: 0 lectures + 0 practices + 24 seminars = total of 24 hours

Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPF-H1B-T completed + OPF-H2A-T parallel

The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

This course is meant to provide the language basis for advanced communication between doctors and patients.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Making up for missed classes

To be discussed with the course tutor.

Reading material

- Obligatory literature

Anamnézis magyarul (Magyar orvosi szaknyelv kezdőknek) by Renáta Halász, 2015. Pécs

- Literature developed by the Department

http://aok.pte.hu/index.php?page=egyseg&egy_id=60&nyelv=eng&menu=okt_anyag

- Notes

- Recommended literature

Lectures

Practices

Seminars

1 Expressing possessing, genitive case

2 Expressing possessing, genitive case

3 Adjectives and nouns: eg. nátha-náthás, nominalization: eg köhög-köhögés

4 Adjectives and nouns: eg. nátha-náthás, nominalization: eg köhög-köhögés

5 Question words, concerning time and location and adverbs of time

6 Question words, concerning time and location and adverbs of time

7 Expressing cause, giving explanation

8 Expressing cause, giving explanation

9 Functions of past tense in medical Hungarian

10 Functions of past tense in medical Hungarian

11 Future tense, modality expressing ability and volition

12 Future tense, modality expressing ability and volition

13 Impersonalization

14 Impersonalization

15 Consolidation test 1

16 Test 1

17 Modality expressing necessity, possibility and prohibition

18 Modality expressing necessity, possibility and prohibition

19 Definite and indefinite conjugation, prefixed verbs

20 Definite and indefinite conjugation, prefixed verbs

21 Imperative forms

22 Imperative forms

23 Giving instructions to patients

24 Test 2.

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Exam topics/questions

http://aok.pte.hu/index.php?page=egyseg&egy_id=60&menu=okt_anyag&nyelv=eng

Participants

Dávidovics Anna (U5A10Z), Dr. Hegedűs Anita (TQQEMK), Dr. Hild Gabriella (HILSWV), Dr. Németh Tímea (X8VRGN), Dr. Rébék-

Nagy Gábor (DGOZG1), Dr. Warta Vilmos (SJYRAV), Eklicsné Dr. Lepenye Katalin (JMXXSC), Krommer Zoltán (MQ5HNA),

Kurdiné Molnár Eszter (VUCECC), Nagy Gabriella (CYMRX3), Nagy Renáta (), Ronczykné Berta Anikó (CJZOFU), Szalai-Szolcsányi

Judit (RBGAPH), Szántóné Dr. Csongor Alexandra (UDKY0J)

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OPF-MGY-T MEDICINAL PLANTS IN THE MECSEK MOUNTAIN - FIELD STUDY 1

Course director: DR. NÓRA PAPP, associate professor

Department of Pharmacognosy [email protected]

2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 2

Number of hours/semester: 12 lectures + 12 practices + 0 seminars = total of 24 hours

Course headcount limitations (min.-max.): 5 – 15 Prerequisites: none

Topic

The course includes 6x2 lectures and 3x4 practice (field work). The aim of the course is to practice the correct identification of medicinal

plants, knowledge of main morphological characters, habitat, collection place, and therapeutical use. The course gives a general overview

on the most frequent medicinal plants, protected and produced species, as well as various vegetation types in the Mecsek mountain and

its environment. In addition, the effect and relationship between abiotic factors and secondary metabolites of plants are also discussed,

which can provide recommendations for collection place and habitat of plants.

Conditions for acceptance of the semester

Maximal absences: 2 /semester.

Mid-term exams

Fulfillment of 2 tests.

Making up for missed classes

http://gytk.pte.hu/en/egyseg/oktatasianyagok/1640

http://aok.pte.hu/en/egyseg/oktatasianyagok/1640

Reading material

- Obligatory literature

- Literature developed by the Department

Lectures downloaded in Neptun.

- Notes

- Recommended literature

Lectures

1 Vegetation types of medicinal plants; ecological factors in habitats I

Dr. Papp Nóra

2 Vegetation types of medicinal plants; ecological factors in habitats I

Dr. Papp Nóra

3 Vegetation types of medicinal plants; ecological factors in habitats II

Dr. Papp Nóra

4 Vegetation types of medicinal plants; ecological factors in habitats II

Dr. Papp Nóra

5 Environmental adaptation of medicinal plants (morphology, phytochemistry); relationship between medicinal plant populations

and their environment

Dr. Papp Nóra

6 Environmental adaptation of medicinal plants (morphology, phytochemistry); relationship between medicinal plant populations

and their environment

Dr. Papp Nóra

7 Vegetation types in the Mecsek mountain I: medicinal plants in beech and karst shrub forests

Dr. Papp Nóra

8 Vegetation types in the Mecsek mountain II: medicinal plants in rock grasses, swamps and alder woods

Dr. Papp Nóra

9 Medicinal plants at road edge vegetations, planted and protected plants of the Mecsek mountain I

Dr. Papp Nóra

10 Medicinal plants at road edge vegetations, planted and protected plants of the Mecsek mountain II

Dr. Papp Nóra

11 Identification of medicinal plants used Identification Handbooks, methods in field work I

Dr. Papp Nóra

12 Identification of medicinal plants used Identification Handbooks, methods in field work II

Dr. Papp Nóra

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Practices

1 Identification of medicinal plants in rock grasses (Tettye)

2 Identification of medicinal plants in rock grasses (Tettye)

3 Identification of medicinal plants in rock grasses (Tettye)

4 Identification of medicinal plants in rock grasses (Tettye)

5 Identification of medicinal plants in oak forest (Dömörkapu)

6 Identification of medicinal plants in oak forest (Dömörkapu)

7 Identification of medicinal plants in oak forest (Dömörkapu)

8 Identification of medicinal plants in oak forest (Dömörkapu)

9 Identification of medicinal plants in swamp (Pellérd)

10 Identification of medicinal plants in swamp (Pellérd)

11 Identification of medicinal plants in swamp (Pellérd)

12 Identification of medicinal plants in swamp (Pellérd)

Seminars

Exam topics/questions

According to the topics of the course.

Participants

Dr. Papp Nóra (S3PA4G)

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OPF-PLH-T THE PLACEBO EFFECT

Course director: TIBOR SZOLCSÁNYI, assistant professor

Department of Behavioural Sciences [email protected]

1 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 2

Number of hours/semester: 12 lectures + 0 practices + 0 seminars = total of 12 hours

Course headcount limitations (min.-max.): 5 – 50 Prerequisites: none

The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

The use of placebo effect has been an inherent part of medicine for thousands of years, and in the recent decades it has become an

inevitable element of medical research due to the introduction of placebo controlled clinical trials. In spite of this fact the research

methodology to measure the effectiveness of placebo effect has been clarified only in the last 10-15 years. At the same time researches

on the neurochemical mechanisms underlying the placebo effect have gained a new impetus. Currently, therefore, we have a much greater

understanding of placebo effect in the context of evidence-based medicine than before, which raises new types of ethical questions as

well. During the course we will examine the different aspects of the phenomenon of placebo effect, and the students will gain knowledge

of the current research results on the field. The main topics of the course: the history of the use of placebo therapies, the role of placebo

effect in medical research, the psycho-social factors that are able to induce placebo effect, neurochemical mechanisms underlying the

placebo effect, the ethical implications of the use of placebo effect in medical treatments.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Written test taking place in the last class. To improve the grade, the test can be repeated two times in the first two weeks of the exam

period.

Making up for missed classes

According to the Code of Studies and Examinations.

Reading material

- Obligatory literature

Franklin G. Miller; Luna Colloca; Ted J. Kaptchuk: The Placebo Effect: Illness and Interpersonal Healing, Perspect Biol Med. 2009

; 52(4)

Damien G. Finniss; Ted J. Kaptchuk; Franklin G. Miller; Fabrizio Benedetti: Biological, Clinical and Ethical Advances of Placebo

Effects, Lancet 2010; 375; 686-695

Franklin G. Miller; Donald L. Rosenstein: The Nature and Power of the Placebo Effect, Journal of Clinical Epidemiology 59, 2006;

331-335

Fabrizio Benedetti: Mechanisms of Placebo and Placebo-Related Effects across Diseases and Treatments, Annual Review of

Pharmacology and Toxicology, Vol. 48; 2008; 33-60.

Jozien M. Bensing; William Verheul: The Silent Healer: The Role of Communication in Placebo Effects, Patient Education and

Counseling 80, 2010; 293-299

- Literature developed by the Department

Additional materials: Neptun MeetStreet

- Notes

--

- Recommended literature

Fabrizio Benedetti: Placebo Effect, Oxford University Press, Oxford, 2009

Lectures

Lectures

1 Introduction, definitions of placebo effect

Dr. Szolcsányi Tibor

2 The use of placebo effect in the history of medicine

Dr. Szolcsányi Tibor

3 The use of placebo effect in the context of medical research: the introduction of randomized placebo controlled clinical trials and

its consequences

Dr. Szolcsányi Tibor

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4 The methodological and ethical challenges of placebo research

Dr. Szolcsányi Tibor

5 The main forms of placebo effect (expectancy based / classical conditioning / affective modulation) and their effectiveness in

different diseases

Dr. Szolcsányi Tibor

6 The neurochemistry of placebo effect: placebo analgesia

Dr. Szolcsányi Tibor

7 The neurochemistry of placebo effect: the cardiovascular and the respiratory system, immune response and hormone secretion,

Parkinson disease

Dr. Szolcsányi Tibor

8 The neurochemistry of placebo effect: further results

Dr. Szolcsányi Tibor

9 An overview of the psycho-social factors that are able to induce placebo effect

Dr. Szolcsányi Tibor

10 Pain management through psychological interventions and placebo analgesia

Dr. Szolcsányi Tibor

11 Ethical implications: how to enhance the placebo effect through improving the physician-patient relationship

Dr. Szolcsányi Tibor

12 Written test

Dr. Szolcsányi Tibor

Practices

Seminars

Exam topics/questions

--

Participants

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OPF-VVE-T VACCINATION, ANTI-VACCINATION MOVEMENTS: DO MORE HARM THAN GOOD

Course director: DR. KATALIN SZENDI, assistant professor

Department of Public Health Medicine [email protected]

1 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 2

Number of hours/semester: 12 lectures + 0 practices + 0 seminars = total of 12 hours

Course headcount limitations (min.-max.): 5 – 30 Prerequisites: none

The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

Vaccination belongs to one of the most successful modern health care programmes that decreased significantly the number of severe

infectious diseases. In today’s world experts are unable to compete with the media. Several delusions circulate infiltrating the public

opinion related to vaccines. The most susceptible target audience of these beliefs are the half-educated laymen who believe in the media

created pseudoscience. The activity of stubborn anti-vaccine minorities can be dangerous because that may open up new chances of the

spread of infectious diseases.

The objective of the course is to deepen the knowledge of vaccinations concerning the background, benefits, achievements and failures,

and the course also serves as a thought provoking initiation for practitioners relating to possible actions against the anti-vaccination

movements.

Conditions for acceptance of the semester

Participation in lectures and practicals is obligatory which is registered.

Absences should not exceed 15% (2x45 min). Otherwise signature of grade book is denied.

Mid-term exams

Making up for missed classes

There are no make-up classes.

Reading material

- Obligatory literature

- Literature developed by the Department

Educational material uploaded on Neptun.

- Notes

- Recommended literature

Stanley A. Plotkin. History of Vaccine Development. Springer 2011.

Vaccine Fact Book 2013. http://www.phrma.org/sites/default/files/pdf/PhRMA_Vaccine_FactBook_2013.pdf

WHO, UNICEF, World Bank. State of the world’s vaccines and immunization, 3rd ed., Geneva, World Health Organization, 2009.

Lectures

1 History of vaccines and anti-vaccination movements

Dr. Szendi Katalin

2 Epidemiology of infectious diseases, morbidity and mortality rates before and after vaccine introduction. Is there any benefit of

vaccination?

Dr. Szendi Katalin

3 Epidemiological studies on vaccination, are there any at all?

Dr. Szendi Katalin

4 Morbidity, mortality, incidence, prevalence. Statistics, data availability, official sources. Are there enough and reliable data to

prove the effectiveness or safety of vaccines?

Dr. Szendi Katalin

5 Groups of vaccinations. Why are they compulsory?

Dr. Szendi Katalin

6 Types of vaccinations. Are there any unnecessary ones (e.g. BCG)? Is it possible that the only purpose of the pharmaceutical

industry is to increase their profits?

Dr. Szendi Katalin

7 The function of vaccination, types of immunity. Is artificial induction of immunity good for our immune system? Does it result

in more benefits if the diseases are fought off in a natural way?

Dr. Szendi Katalin

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8 The efficiency of vaccines. Do the European countries with better health indicators also have better epidemiological situation

than Hungary? Questions of herd immunity.

Dr. Szendi Katalin

9 Vaccine effectiveness. Are there any positive health effects, or just does the government want to make us believe in counterfeit

statistical data?

Dr. Szendi Katalin

10 Vaccination safety, components. Are the ingredients in vaccines dangerous? Do they cause any harm to health? Diversity of

conspiracy theories

Dr. Szendi Katalin

11 Risks of vaccines, vaccination health hazards. Do the vaccines do more harm than good? MMR and autism. Mercury and autism.

Aluminium and autism.

Dr. Szendi Katalin

12 Anti-vaccination activities in Hungary and abroad

Dr. Szendi Katalin

Practices

Seminars

Exam topics/questions

Neptun

Participants

Dr. Szendi Katalin (MRDJ71)

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OPF-BAL-T MINERAL AND SPA WATERS, BALNEOLOGY

Course director: DR. CSABA VARGA, professor

Department of Public Health Medicine [email protected]

2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 2

Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours

Course headcount limitations (min.-max.): 5 – 40 Prerequisites: none

Topic

The main educational task of the subject initiating to form state-of-art regarding use and application of mineral and spa waters in Hungary

and EU with special respect of the prevention.

Short description of the course: Delivering up to date hydrological, hydrogeological, physical, chemical, biological knowledge for

students of medicine and other sciences.

Conditions for acceptance of the semester

Maximum of 15 % absence allowed

Mid-term exams

Making up for missed classes

Reading material

- Obligatory literature

- Literature developed by the Department

Neptun

- Notes

- Recommended literature

Lectures

1 Hydrogeology and balneology of mineral and spa waters

Márovics Gergely Péter

2 Hydrogeology of Hungarian mineral and spa waters

Márovics Gergely Péter

3 Correlation of the geological characteristics and the chemical composition

Bérczi Bálint Dániel

4 Hydrology of mineral and spa waters

Bérczi Bálint Dániel

5 Mineral and spa waters in Hungary and Europe

Dr. Varga Csaba

6 Chemical characteristics of mineral and spa waters

Dr. Varga Csaba

7 Inorganic analytical classification. Presence of microelements

Dr. Varga Csaba

8 Inorganic ions, substances an compexes in the therapeutical effect

Dr. Varga Csaba

9 Organic ions, substances and complexes in the therapeutical

Dr. Varga Csaba

10 In situ water analysis. Inorganic analysis

Dr. Varga Csaba

11 Hygienic microbiological analysis

Dr. Varga Csaba

12 Arteficial mineral and medicinal waters

Dr. Varga Csaba

13 Peloids: genesis, chemical/physical/toxicological properties. Hungarian peloids.

Dr. Varga Csaba

14 Mineral and spa water products

Dr. Varga Csaba

15 Introduction to Balneology: objectives and history

Dr. Varga Csaba

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16 Water and ions in the human body

Dr. Varga Csaba

17 External cure with spa waters, mode of action

Dr. Varga Csaba

18 Mechanic, thermal, chemical and psychic actions, Spa reaction

Dr. Varga Csaba

19 Water types in cure

Dr. Varga Csaba

20 Application of spa waters to different diseases

Dr. Varga Csaba

21 Therapeutic applications of peloids

Dr. Varga Csaba

22 Internal use of mineral and medicinal waters, Drinking cure

Dr. Varga Csaba

23 Inhalation cure.

Dr. Varga Csaba

24 Other natural cures: climate cure, physicotherapy, additional therapies

Dr. Varga Csaba

Practices

Seminars

Exam topics/questions

Neptun

Participants

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OPE-TSA-T STATISTICAL ANALYSIS OF THESIS AND STUDENT RESEARCH PROJECTS

Course director: DR. KORNÉLIA FARKAS-BORBÁS, assistant professor

Institute of Bioanalysis [email protected]

1 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ both semesters ▪ recommended semester: 3

Number of hours/semester: 6 lectures + 6 practices + 0 seminars = total of 12 hours

Course headcount limitations (min.-max.): 3 – 20 Prerequisites: none

Topic

This course is for those students who are working on a student research plan or working on their thesis. They can process their own data

and learn the theory of the applied statistical methods as well.

Conditions for acceptance of the semester

Problem solving, oral report

Mid-term exams

Making up for missed classes

Consultation

Reading material

- Obligatory literature

- Literature developed by the Department

Own database

- Notes

- Recommended literature

Andrew F. Siegel: Statistics and Data Analysis. An introduction, John Wiley & Sons, 1988

Douglas G. Altman: Practical Statistics for Medical Research, Chapman & Hall, 1994

P. Armitage and G. Berry: Statistical Methods in Medical Research, Blackwell Science, 1994

Robert R. Sokal / F. James Rohlf: Biometry, W. H. Freeman and Company, New York, 1981

Lectures

1 Set the data and complete the database for statistical processing

Borbásné Dr. Farkas Kornélia

2 Select the right statistical methods

Dr. Pótó László

3 Learn the theory of the selected methods

Dr. Pótó László

4 Interpret the results

Borbásné Dr. Farkas Kornélia

5 Interpret the results

Borbásné Dr. Farkas Kornélia

6 Conclusions

Borbásné Dr. Farkas Kornélia

Practices

1 Set the data and complete the database for statistical processing

2 Select the right statistical methods

3 Learn the theory of the selected methods

4 Learn the theory of the selected methods

5 Interpret the results

6 Interpret the results

Seminars

Exam topics/questions

Participants

Borbásné Dr. Farkas Kornélia (IRWZKJ)

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OPE-WMI-T WEAK MOLECULAR INTERACTIONS

Course director: DR. SÁNDOR KUNSÁGI-MÁTÉ, associate professor

Department of Pharmaceutical Chemistry [email protected]

2 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ both semesters ▪ recommended semester: 3

Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours

Course headcount limitations (min.-max.): 2 – 12 Prerequisites: OPA-GC1-T completed

Topic

Types of molecular interactions. Chemical equilibrium based on the weak molecular interactions. Determination of the chemical

equilibrium and the stoichiometry of the complexes. Correlation between the chemical equilibrium and the free enthalpy. Investigation

of the weak interaction by spectroscopical methods. Application of the Job’s method in the fluorescence measurements. Direct measuring

the interaction enthalpy by differential scanning calorimetry. Interactions of aromatic compounds. Interactions of antibiotics with

membrane elements. Interactions of bioactive molecules with DNA. Investigations of model-systems: interactions of calixarenes with

phenols and fullerenes. Packing of drug molecules by molecular containers. Interactions of bioactive molecules with elements of cell

membranes. Self-assembly of some hormones by weak interactions.

Conditions for acceptance of the semester

Maximum of 15 % absence allowed

Mid-term exams

One written exam during the semester, the acceptance level is 60%.

Making up for missed classes

There is no possibility to make up for a missed lecture and practice

Reading material

- Obligatory literature

David Freifelder: Physical Biochemistry

- Literature developed by the Department

Shyllabus and ppt presentation is available.

- Notes

- Recommended literature

Atkins: Physical Chemistry I-III.

David Freifelder: Physical Biochemistry

Lectures

1 Types of molecular interactions.

Dr. Kunsági-Máté Sándor

2 Types of molecular interactions.

Dr. Kunsági-Máté Sándor

3 Chemical equilibrium based on the weak molecular interactions.

Dr. Kunsági-Máté Sándor

4 Chemical equilibrium based on the weak molecular interactions.

Dr. Kunsági-Máté Sándor

5 Determination of the chemical equilibrium and the stoichiometry of the complexes.

Dr. Kunsági-Máté Sándor

6 Determination of the chemical equilibrium and the stoichiometry of the complexes.

Dr. Kunsági-Máté Sándor

7 Correlation between the chemical equilibrium and the free enthalpy.

Dr. Kunsági-Máté Sándor

8 Correlation between the chemical equilibrium and the free enthalpy.

Dr. Kunsági-Máté Sándor

9 Investigation of the weak interaction by measuring the fluorescence.

Dr. Kunsági-Máté Sándor

10 Investigation of the weak interaction by measuring the fluorescence.

Dr. Kunsági-Máté Sándor

11 Application of the Job’s method in the fluorescence measurements.

Dr. Kunsági-Máté Sándor

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12 Application of the Job’s method in the fluorescence measurements.

Dr. Kunsági-Máté Sándor

13 Direct measuring the interaction enthalpy by differential scanning calorimetry.

Dr. Kunsági-Máté Sándor

14 Direct measuring the interaction enthalpy by differential scanning calorimetry.

Dr. Kunsági-Máté Sándor

15 Interactions of aromatic compounds. Interactions of bioactive compounds with DNA.

Dr. Kunsági-Máté Sándor

16 Interactions of aromatic compounds. Interactions of bioactive compounds with DNA.

Dr. Kunsági-Máté Sándor

17 Investigations of model-systems: interactions of calixarenes with phenols and fullerenes.

Dr. Kunsági-Máté Sándor

18 Investigations of model-systems: interactions of calixarenes with phenols and fullerenes.

Dr. Kunsági-Máté Sándor

19 Investigations of the conformation changes of proteins by fluorescence and calorimetric methods.

Dr. Kunsági-Máté Sándor

20 Investigations of the conformation changes of proteins by fluorescence and calorimetric methods.

Dr. Kunsági-Máté Sándor

21 Investigations of the conformation changes of proteins by fluorescence and calorimetric methods.

Dr. Kunsági-Máté Sándor

22 Controlling of self-assembly of some hormones by weak interactions.

Dr. Kunsági-Máté Sándor

23 Controlling of self-assembly of some hormones by weak interactions.

Dr. Kunsági-Máté Sándor

24 Controlling of self-assembly of some hormones by weak interactions.

Dr. Kunsági-Máté Sándor

25 Modifications of structure of serum albumins by molecular capsules. Interactions of molecular capsules with aromatic amino

acids at terminated positions.

Dr. Kunsági-Máté Sándor

26 Effect of Molecular Environment on the Formation Kinetics of Complexes of Malvidin-3-O-glucoside with Caffeic Acid and

Catechin

Dr. Kunsági-Máté Sándor

27 Competitive hydrogen bonds associated with the effect of primycin antibiotic on oleic acid as a building block of plasma

membranes.Complex formation between primycin and ergosterol: entropy - driven initiation of modification of the fungal plasma

membrane structure

Dr. Kunsági-Máté Sándor

28 Role of the Conformational Freedom of the Skeleton in the Complex Formation Ability of Resorcinarene Derivatives toward a

Neutral Phenol Guest

Dr. Kunsági-Máté Sándor

Practices

Seminars

Exam topics/questions

Types of molecular interactions.

Chemical equilibrium based on the weak molecular interactions.

Determination of the chemical equilibrium and the stoichiometry of the complexes.

Correlation between the chemical equilibrium and the Gibbs free energy.

Investigation of the weak interaction by spectroscopical methods.

Application of the Job”s method in the fluorescence measurements.

Direct measuring the interaction enthalpy by differential scanning calorimetry.

Interactions of aromatic compounds.

Interactions of bioactive compounds with DNA.

Investigations of model-systems: interactions of calixarenes with phenols and fullerenes.

Packing of drug molecules by molecular containers.

Interactions of bioactive molecules with elements of cell membranes.

Self-assembly of some hormones by weak interactions.

Participants

Dr. Kunsági-Máté Sándor (UYZM2Q)

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OPE-TSS-T MEDICAL APPLICATIONS OF MASS SPECTROMETRY

Course director: DR. LÁSZLÓ MÁRK, associate professor

Department of Biochemistry and Medical Chemistry [email protected]

2 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ autumn semester ▪ recommended semester: 3

Number of hours/semester: 20 lectures + 0 practices + 0 seminars = total of 20 hours

Course headcount limitations (min.-max.): 3 – 50 Prerequisites: none

The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

In medical sciences, emphasis is increasingly placed on instrumental techniques and accurate, quantitative measurements. This course is

give an overall review about the modern mass spectrometry and it shows the medical applications of the MS in the clinical and diagnostic

practice.

Topics:

Introduction to MS. Ionsources, analizators, detectors. Separation techniques. Sample handling. Biomedical sampling. Bioinformatics.

Proteomics, metabolomics and lipidomics. Biomarker discovery. Mass spectrometric imaging techniques.

Conditions for acceptance of the semester

Written exam. Max. absences: 20%.

Mid-term exams

Not possible.

Making up for missed classes

Not possible.

Reading material

- Obligatory literature

- Literature developed by the Department

Lecture slides and notes.

- Notes

- Recommended literature

Vékey et al: Medical Applications of Mass Spectrometry, 2008.

Hoffman et al: Mass Spectrometry, 2007

Lectures

1 Introduction to mass spectrometry

Dr. Márk László

2 Introduction to mass spectrometry

Dr. Márk László

3 Ionsources

Dr. Márk László

4 Analyzers

Dr. Márk László

5 The mass spectrum.

Dr. Márk László

6 Sample matrices, Sampling procedures.

Dr. Márk László

7 Sample pretreatment, separation techniques.

Dr. Márk László

8 Sample pretreatment, separation techniques.

Dr. Márk László

9 Proteomics

Dr. Márk László

10 Proteomics

Dr. Márk László

11 Metabolomics

Dr. Márk László

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12 Metabolomics

Dr. Márk László

13 Investigation of endocrine system

Dr. Márk László

14 Investigation of endocrine system

Dr. Márk László

15 Pathological biomarker discovery

Dr. Márk László

16 Pathological biomarker discovery

Dr. Márk László

17 Lipidomics

Dr. Márk László

18 Lipidomics

Dr. Márk László

19 Imaging mass spectrometry

Dr. Márk László

20 Imaging mass spectrometry

Dr. Márk László

Practices

Seminars

Exam topics/questions

Ionsources.

Analizators.

Detectors.

Separation techniques.

Sample handling. Biomedical sampling.

Bioinformatics.

Proteomics.

Metabolomics

Lipidomics.

Biomarker discovery.

Mass spectrometric imaging techniques.

MS of endocrine system.

Participants

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OPE-BEE-T BASICS OF EPIDEMIOLOGY

Course director: DR. TÍMEA VARJAS, assistant professor

Department of Public Health Medicine [email protected]

1 credit ▪ midsemester grade ▪ Elective subject for the Medical-biological module ▪ autumn semester ▪ recommended semester: 3

Number of hours/semester: 12 lectures + 0 practices + 0 seminars = total of 12 hours

Course headcount limitations (min.-max.): 1 – 20 Prerequisites: none

The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

During the semester students are acquainted with the basics of epidemiology and epidemiological studies frequently used in scientific

literature. With this knowledge one can easily elucidate and interpret scientific publications.

This course was established especially for pharmacist and dentist students.

Conditions for acceptance of the semester

Absences should not exceed 15% of lectures and practicals (2x45 min). Otherwise signature of grade book is denied.

Mid-term exams

Examination: written test

Making up for missed classes

Based on individual consideration

Reading material

- Obligatory literature

- Literature developed by the Department

PPT-presentations (Neptun)

- Notes

- Recommended literature

Lectures

1 The concept of epidemiology

Dr. Szabó István

2 The historical context

Dr. Szabó István

3 Epidemiology and public helath

Dr. Szabó István

4 Achievments in epidemiology

Dr. Szabó István

5 Measuring health and disease

Dr. Szabó István

6 Epidemiological studies

Dr. Szabó István

7 Epidemiological studies

Dr. Szabó István

8 Epidemiological studies

Dr. Szabó István

9 Potential errors in epidemiological studies

Dr. Szabó István

10 The concept of Evidence Based Medicine

Dr. Szabó István

11 Basic epidemiological calculations

Dr. Szabó István

12 Analyzis of selected scientific publications

Dr. Szabó István

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Practices

Seminars

Exam topics/questions

Neptun

Participants

Dr. Szabó István (BF4MF6)

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OPE-EHS-T HUNGER, SATIETY AND DISTURBANCES OF BODY WEIGHT REGULATION

Course director: DR. LÁSZLÓ LÉNÁRD I, professor emeritus

Institute of Physiology [email protected]

1 credit ▪ midsemester grade ▪ Elective subject for the Medical-biological module ▪ autumn semester ▪ recommended semester: 3

Number of hours/semester: 12 lectures + 0 practices + 0 seminars = total of 12 hours

Course headcount limitations (min.-max.): 5 – 25 Prerequisites: OPO-Z2E-T completed + OPO-G2B-T completed

The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

Based on recent results, feeding related physiological and pathophysiological mechanisms will be discussed. Students will be trained to

understand these mechanisms. The knowledge based on this course will highly contribute to better understanding further clinical studies

on human diseases.

Peripheral and central mechanisms of hunger, satiety, salt appetite and body weight regulation will be discussed. Lectures will include

the following topics: Neural and humoral processes. Peripheral and central glucose-monitoring system. The role of neuropeptides in the

control of feeding and hydromineral balance. Pathological processes: obesity, bulimia, anorexia.

Conditions for acceptance of the semester

Absence from no more than 25% of the lectures.

Mid-term exams

Written exams.

Making up for missed classes

Reading material

- Obligatory literature

- Literature developed by the Department

- Notes

Notes taken at the lectures.

- Recommended literature

Lectures

1 Basic parameters: caloric intake, energy expenditure, measurement of food and water intake, body weight and body mass index.

Body weight curves during development, adulthood and senescence.

Dr. Lénárd László I

2 Peripheral and central mechanisms of body weight regulation.

Dr. Lénárd László I

3 Endocrine mechanisms: the role of different hormones.

Dr. Lénárd László I

4 Body weight loss, obesity. Long run pathological consequences of obesity.

Dr. Lénárd László I

5 Hunger and satiety. Motivational mechanisms. Overeating, rejection.

Dr. Lénárd László I

6 Hypothalamic dual centers. The role of limbic system in hunger and satiety.

Dr. Lénárd László I

7 Peripheral glucose related signals. The central glucose monitoring system.

Dr. Lénárd László I

8 Food rewarded learning, the role of reinforcement. Aversive learning, the role of conditioned taste aversion in feeding habits.

Dr. Lénárd László I

9 The sight, odor, taste and texture of foods and their detection in the limbic system. Ingestive and rejective mimetic responses and

their genetic determination. The role of monoamines in the regulation of feeding. Similarities of food rewarded learning and

addictive behavior. The role of dopamine and neuropeptides.

Dr. Lénárd László I

10 Orexigenic and anorexigenic neuropeptides.

Dr. Lénárd László I

11 The role of the central angiotensinergic system in drinking and hydromineral balance.

Dr. Lénárd László I

12 Childhood obesity and cognitive processes. Anorexia nervosa, bulimia and binge eating. Clinical relevance of animal experiments

Dr. Lénárd László I

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Practices

Seminars

Exam topics/questions

Participants

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OPF-TG1-T STUDENT PROJECT RESEARCH FOR STUDENTS OF PHARMACEUTIST PROGRAMME 1

Course director: DR. GYÖRGYI HORVÁTH, associate professor

Department of Pharmacognosy [email protected]

2 credit ▪ midsemester grade ▪ Optional subject ▪ both semesters ▪ recommended semester: 3

Number of hours/semester: 0 lectures + 24 practices + 0 seminars = total of 24 hours

Course headcount limitations (min.-max.): 1 – 50 Prerequisites: none

Topic

The course aims at promoting of students to make student research projects on the field of pharmaceutical sciences. Furthermore, we

wish to give individual possibilities of students to perform experiments in the different pharmaceutical institutes involved into Students’

Research Society.

Conditions for acceptance of the semester

The continuous student’s work is recommended. The continuous enrollment of consecutive courses can be stopped and continued in

further semesters.

The prerequisite of this course (TDK 1): registration of the student in the database of Students’ Research Society.

Mid-term exams

- Topic plan of student’s research project with the confirmation of supervisor

- Introduction of scientific articles found by the student in databases

- The topic plan and articles must be sent for course supervisor at the end of 13th week of the semester.

Making up for missed classes

There is no possibility.

Reading material

- Obligatory literature

- Literature developed by the Department

- Notes

- Recommended literature

ScienceDirect database

Lectures

Practices

1-24 Research.

Seminars

Exam topics/questions

Not applicable.

Participants

Dr. Horváth Györgyi (GDLTCH)

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OPF-TMB-T MOLECULAR BIOLOGY OF TUMORS

Course director: DR. EDINA PANDUR, assistant professor

Department of Pharmaceutical Biology [email protected]

2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 3

Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours

Course headcount limitations (min.-max.): 3 – 30 Prerequisites: OPO-GL1-T completed + OPO-G2B-T completed

Topic

During the course we will discuss the molecular mechanisms of tumor development. We will deal with characteristic features of tumor

cells, and cancers. The function of influencing factors, risk factors, causes, the underlying molecular mechanisms, e.g. mutations, the

role of oncogenes and tumor-suppressor genes, DNA repair, epigenetics and the role of immune system will be discussed in detail. We

will emphasize the function of cell signaling pathways and the failure of apoptosis in tumorigenesis. We will speak about the molecular

mechanisms of invasion and metastasis of tumors, the genes and proteins which have a crucial role in these processes. The participants

will get an insight into the molecular diagnosis, genetic aberrations, and molecular alterations of human cancers. We will discuss the

possibilities for cancer therapies, the new approaches such as gene therapy and immunotherapy.

Conditions for acceptance of the semester

Max. 3 absences

Mid-term exams

One assay, one midterm exam.

Making up for missed classes

Personal consultation

Reading material

- Obligatory literature

- Literature developed by the Department

Educational materials will be uploaded to Neptune MeetStreet.

- Notes

- Recommended literature

Lauren Pecorino: Molecular Biology of Cancer

Wolfgang Arthur Schulz: Molecular Biology of Human Cancers

Lectures

1 Introduction to cancers: classification and characterization of cancers, causes of cancer, properties of cancer cells, principles of

therapies, targets of therapies

Dr. Pandur Edina

2 Introduction to cancers: classification and characterization of cancers, causes of cancer, properties of cancer cells, principles of

therapies, targets of therapies

Dr. Pandur Edina

3 Tumor genetics: mutations, carcinogenic agents, inheritance, tumor genes, defects in DNA repair and predispositions to cancer,

cell protection mechanisms

Dr. Pandur Edina

4 Tumor genetics: mutations, carcinogenic agents, inheritance, tumor genes, defects in DNA repair and predispositions to cancer,

cell protection mechanisms

Dr. Pandur Edina

5 Tumor epigenetics: mechanisms of epigenetic inheritance, imprinting, DNA methylation, epigenetics of cell differentiation and

tissue homeostasis

Dr. Poór Viktor Soma

6 Tumor epigenetics: mechanisms of epigenetic inheritance, imprinting, DNA methylation, epigenetics of cell differentiation and

tissue homeostasis

Dr. Poór Viktor Soma

7 Oncogenes and tumor-suppressor genes

Dr. Pandur Edina

8 Oncogenes and tumor-suppressor genes

Dr. Pandur Edina

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9 The cell cycle, apoptosis and senescence: checkpoints, therapeutic targets and inhibitors, molecular mechanisms of apoptosis,

replicative senescence and its disturbances in human cancers

Pap Ramóna

10 The cell cycle, apoptosis and senescence: checkpoints, therapeutic targets and inhibitors, molecular mechanisms of apoptosis,

replicative senescence and its disturbances in human cancers

Pap Ramóna

11 Signaling pathways in tumors: MAPK, PI3K, TP53 network, NFkappaB, TGFbeta, STAT signaling

Dr. Pandur Edina

12 Signaling pathways in tumors: MAPK, PI3K, TP53 network, NFkappaB, TGFbeta, STAT signaling

Dr. Pandur Edina

13 Invasion and metastasis: genes and proteins involved in cell-to-cell, cell-matrix adhesion, in extracellular matrix remodeling

during tumor invasion; angiogenesis.

Dr. Pandur Edina

14 Invasion and metastasis: genes and proteins involved in cell-to-cell, cell-matrix adhesion, in extracellular matrix remodeling

during tumor invasion; angiogenesis.

Dr. Pandur Edina

15 The role of immune system in tumors: inflammation, infections, cancer vaccines, inhibition of the immune system

Pap Ramóna

16 The role of immune system in tumors: inflammation, infections, cancer vaccines, inhibition of the immune system

Pap Ramóna

17 Stem cells and cancer: Wnt signaling, Hh signaling, differentiation therapy

Dr. Pandur Edina

18 Stem cells and cancer: Wnt signaling, Hh signaling, differentiation therapy

Dr. Pandur Edina

19 Cancer prevention: nutrients, energy metabolism of tumors, hormones and gene interactions

Pap Ramóna

20 Cancer prevention: nutrients, energy metabolism of tumors, hormones and gene interactions

Pap Ramóna

21 Diagnosis of tumors: molecular diagnosis, molecular detection and classification

Jánosa Gergely

22 Diagnosis of tumors: molecular diagnosis, molecular detection and classification

Jánosa Gergely

23 Human cancers I: common properties, genetic aberrations, molecular alterations, histology and etiology of cancers

Dr. Tóth Dénes

24 Human cancers I: common properties, genetic aberrations, molecular alterations, histology and etiology of cancers

Dr. Tóth Dénes

25 Human cancers II: common properties, genetic aberrations, molecular alterations, histology and etiology of cancers

Dr. Tóth Dénes

26 Human cancers II: common properties, genetic aberrations, molecular alterations, histology and etiology of cancers

Dr. Tóth Dénes

27 Drugs in cancer therapy: molecular mechanisms of cancer chemotherapy, targeted drug therapy, immunotherapy, gene therapy

Dr. Poór Miklós

28 Drugs in cancer therapy: molecular mechanisms of cancer chemotherapy, targeted drug therapy, immunotherapy, gene therapy

Dr. Poór Miklós

Practices

Seminars

Exam topics/questions

Simple choice test based on the lectures.

Participants

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OPF-SSG-T HISTOLOGY SEMINAR FOR PHARMACY STUDENTS

Course director: DR. GABRIELLA HORVÁTH-OPPER, associate professor

Department of Anatomy [email protected]

2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 3

Number of hours/semester: 0 lectures + 0 practices + 24 seminars = total of 24 hours

Course headcount limitations (min.-max.): 5 – 25 Prerequisites: OPO-AI2-T parallel

Topic

The aim of the subject is to complete the knowledge about structure of organ systems. Besides gross anatomy and basic histological

knowledge presented in mandatory anatomy courses, the ‘Histology seminars for pharmacy students’ offers better understanding of

histological background of physiological and oathophysiological processes and conditions.

Conditions for acceptance of the semester

The semester can not be accepted over 2 absences.

Mid-term exams

Multimedia test on last seminar.

Making up for missed classes

Not possible.

Reading material

- Obligatory literature

- Literature developed by the Department

http://an-server.pote.hu

- Notes

- Recommended literature

Lectures

Practices

Seminars

1 Histology of the skin I.

2 Histology of the skin II.

3 Histology of the gastrointestinal tract I.

4 Histology of the gastrointestinal tract II.

5 Histology of the gastrointestinal tract III.

6 Histology of the gastrointestinal tract IV.

7 Histology of the gastrointestinal tract V.

8 Histology of the gastrointestinal tract VI.

9 Histology of the kidney

10 Respiratory system.

11 Histology of the male genitalia I.

12 Histology of the male genitalia II.

13 Histology of the female genitalia I.

14 Histology of the female genitalia II.

15 Histology of the female genitalia III.

16 Histology of the female genitalia IV.

17 Endocrine organs I.

18 Endocrine organs II.

19 Histology of the peripheral nervous system i.

20 Histology of the peripheral nervous system II.

21 Eyebulb I.

22 Eyebulb II.

23 Test

24 Test

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Exam topics/questions

http://an-server.pote.hu

Participants

Gaszner Tamás (YX6IQ5)

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OPF-MGE-T MOLECULAR GERONTOLOGY

Course director: DR. KRISZTIÁN KVELL, associate professor

Department of Pharmaceutical Biotechnology [email protected]

1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 3

Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours

Course headcount limitations (min.-max.): 5 – 200 Prerequisites: OPE-MS1-T completed

The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

The curriculum covers physiological aspects of ageing and the molecular background of the ageing process, at cell, intracellular signaling

and nucleic acid level. It highlights the potential molecular intervention possibilities to slow down the ageing process and decrease

development of age related diseases.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Writing test

Making up for missed classes

None

Reading material

- Obligatory literature

- Literature developed by the Department

- Notes

www.medbiotech.com

- Recommended literature

Lectures

1 Basic Knowledge in Gerontology

Dr. Kvell Krisztián

2 Aging Theories

Dr. Kvell Krisztián

3 Mitochondrial Aging

Dr. Kvell Krisztián

4 Aging and Gene Expression

Dr. Kvell Krisztián

5 Genetic Background of Longevity

Dr. Kvell Krisztián

6 Alterations of the Genome due to Aging, Senescence and Cancer

Dr. Kvell Krisztián

7 Cellular Effects of Acute and Chronic Stress

Dr. Kvell Krisztián

8 Metabolism and Longevity I

Dr. Kvell Krisztián

9 Metabolism and Longevity II

Dr. Kvell Krisztián

10 Senescence-related Intracellular Pathologies

Dr. Kvell Krisztián

11 Senescence-related Intracellular Pathologies

Dr. Kvell Krisztián

12 Molecular Mechanisms of Interventions

Dr. Kvell Krisztián

13 Invited Lecturer I

Dr. Kvell Krisztián

14 Invited Lecturer II

Dr. Kvell Krisztián

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Practices

Seminars

Exam topics/questions

MeetStreet

www.medbiotech.com

Participants

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OPF-IPM-T INNOVATION AND PROJECT MANAGEMENT FROM A BUSINESS PERSPECTIVE (KÜLÖN

KURZUS!!!)

Course director: DR. RITA BOGNÁR, research associate professor

Department of Biochemistry and Medical Chemistry [email protected]

2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 3

Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours

Course headcount limitations (min.-max.): 1 – 24 Prerequisites: none

The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

The main objective of the innovation and project management course is to develop the business orientation skills of the students, while

deepening their knowledge in project management theory, methods and practice. Participants will have the capability how to develop

innovative projects for business.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Written test will be on the week 13.

Making up for missed classes

No way.

Reading material

- Obligatory literature

Not relevant.

- Literature developed by the Department

Lectures in pdf form will be available on Neptun Meet Street.

- Notes

Not relevant.

- Recommended literature

1. Joseph W. Weiss, Robert K. Wysocki (1992): 5-Phase Project Management: A Practical Planning & Implementation Guide,

Addison-Wesley

2. John Hauser, Gerard J. Tellis and Abbie Griffin: A Review and Agenda for „Marketing Science”, Marketing Science, Vol. 25, No.

6, 25th Anniversary Issue (Nov. - Dec., 2006), pp. 687-717

3. Barbara J. Gabrys, Jane A. Langdale (2012): How to succeed as a scientist, From Postdoc to Professor, Cambridge University

Press, New York, pp.45-57.

Lectures

1 Basics of project management (definition, objectives)

Dr. Bognár Rita

2 Global business overview

Dr. Bognár Rita

3 Project life cycle

Dr. Bognár Rita

4 Different type of business organization

Dr. Bognár Rita

5 Project initialisation (structure, work packages)

Dr. Bognár Rita

6 Leadership of a project

Dr. Bognár Rita

7 Human resource management (team building, teamwork)

Dr. Bognár Rita

8 Project planning 1. (time, resources)

Dr. Bognár Rita

9 Project planning 2. (cost, risk, communication)

Dr. Bognár Rita

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10 Project network

Dr. Bognár Rita

11 Project communication tools

Dr. Bognár Rita

12 Project protocol

Dr. Bognár Rita

13 Financial management 1. (Main budget categories)

Dr. Bognár Rita

14 Financial management 2.

Dr. Bognár Rita

15 Procurement management

Dr. Bognár Rita

16 Contracts

Dr. Bognár Rita

17 Risk management

Dr. Bognár Rita

18 Conflict management

Dr. Bognár Rita

19 Project controlling and monitoring

Dr. Bognár Rita

20 Project reporting

Dr. Bognár Rita

21 Project closing

Dr. Bognár Rita

22 Project maintenance

Dr. Bognár Rita

23 Innovation management 1.(Intellectual properties)

Dr. Bognár Rita

24 Innovation management 2. (Patent)

Dr. Bognár Rita

Practices

Seminars

Exam topics/questions

Neptun Meet Street

Participants

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OPF-HB1-T HOW TO ACHIEVE BETTER GRADE IN ORGANIC CHEMISTRY 1

Course director: DR. BALÁZS BOGNÁR, assistant professor

Department of Organic and Pharmacological Chemistry [email protected]

1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 3

Number of hours/semester: 0 lectures + 0 practices + 10 seminars = total of 10 hours

Course headcount limitations (min.-max.): 2 – 20 Prerequisites: OPA-S1E-T parallel + OPA-GC1-T completed

Topic

The aim of the course is to help the students to understand the important reaction mechanisms, and find the connections between the

different topics.

1. Reaction mechanisms in organic chemistry

2. Projection structures, radical substitution

3. Electrophilic addition

4. Electrophilic aromatic substitution

5. Nucleophilic substitution 1, alkyl halides

6. 1. test

7. Nucleophilic substitution 2, organometallics, alcohols, phenols, ethers.

8. Aromatic nucleophilic substitutions

9. Stereochemistry

10. 2. test

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Nincs.

Making up for missed classes

Nincs

Reading material

- Obligatory literature

- Literature developed by the Department

The worksheets will be handed on the seminar.

- Notes

- Recommended literature

Estelle K. Meislich; Herbert Meislich; Jacob Sharefkin: Schaum’s Series 3000 Solved Problems In Organic Chemistry, McGraw-

Hill, Inc., New York, 1994

T. W. Graham Solomons: Organic Chemistry, 7th edition, Wiley and Sons, New York, 2000

John McMurry, Eric Simanek: Fundamentals of Organic Chemistry, 6th edition, Thomson Brooks/Cole, Belmont, 2007

Lectures

Practices

Seminars

1 Reaction mechanisms in organic chemistry.

2 Projection structures, radical substitutions and nomenclature of alkanes.

3 Reaction of alkenes and alkynes: electrophilic addition, oxidations.

4 Aromaticity, electrophilic aromatic substitution: mechanism, examples.

5 Nucleophilic substitutions of alkyl halides.

6 1. test (alkanes, alkenes, alkynes, aromatics, organohalides).

7 Nucleophilic substitution 2: synthesis and reactions organometallics, alcohols, phenols, ethers.

8 Aromatic nucleophilic substitutions of carbocycles.

9 Stereochemistry: classification of isomerism, absolut configuration.

10 2. test: alcohols, phenols, ethers, organometallics, isomerism.

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Exam topics/questions

There is no exam.

Participants

Dr. Bognár Balázs (U34DM4)

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OPF-EBK-T FOOD SAFETY AND CRISIS SITUATIONS

Course director: DR. TÍMEA VARJAS, assistant professor

Department of Public Health Medicine [email protected]

1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 3

Number of hours/semester: 12 lectures + 0 practices + 0 seminars = total of 12 hours

Course headcount limitations (min.-max.): 4 – 30 Prerequisites: none

The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

Although food legislation and legal background is strict in EU some food safety crises and emergencies occur we can hear just a few

word in the media about. This course „pulls the veil” of the background, causes and concealed information of food safety crises. Topics

are about the most interesting and important information of these situations.

Conditions for acceptance of the semester

Absences should not exceed 15% of lectures and practicals (2x45 min). Otherwise signature of grade book is denied.

Mid-term exams

Examination: written test

Making up for missed classes

based on individual consideration

Reading material

- Obligatory literature

- Literature developed by the Department

PPT-presentations (Neptun)

- Notes

- Recommended literature

Lectures

1 Introduction

Dr. Raposa László Bence

2 European and Hungarian food safety regulation

Dr. Raposa László Bence

3 Cases and concealed facts I. (Historical overview)

Dr. Raposa László Bence

4 Cases and concealed facts II.

Dr. Raposa László Bence

5 Crisis management and communication I.

Dr. Raposa László Bence

6 Crisis management and communication II.

Dr. Raposa László Bence

7 Food industry "tricks": Changes which the layman does not realize

Dr. Raposa László Bence

8 Food industry "tricks": Changes which the layman does not realize

Dr. Raposa László Bence

9 Actual food safety crisis

Dr. Raposa László Bence

10 Actual food safety crisis

Dr. Raposa László Bence

11 Summary

Dr. Raposa László Bence

12 Exam

Dr. Raposa László Bence

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Practices

Seminars

Exam topics/questions

Neptun

Participants

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OPF-H3B-T MEDICAL HUNGARIAN 3B - MEDICAL COMMUNICATION IN PRACTICE FOR STUDENTS OF

PHARMACY

Course director: GABRIELLA NAGY, language teacher

Department of Languages for Specific Purposes [email protected]

2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 3

Number of hours/semester: 0 lectures + 0 practices + 24 seminars = total of 24 hours

Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPE-H3A-T parallel + OPE-H2B-T completed

Topic

This course serves the skills development based on language and communicative functions acquired in course 3A.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Making up for missed classes

In the case of absences up to 25% of total class time, oral examination will have to be taken.

Reading material

- Obligatory literature

- Literature developed by the Department

Mária Győrffy: English for Doctors, Idióma Bt. Pécs, 2001 - can be purchased in the Department

- Notes

- Recommended literature

--

Lectures

Practices

Seminars

1 Family History, social history and previous diseases - Listening comprehension and speaking skills

2 Family History, social history and previous diseases - Listening comprehension and speaking skills

3 Complaint and Pain - Listening comprehension and speaking skills

4 Complaint and Pain - Listening comprehension and speaking skills

5 Headache, dizziness - Listening comprehension and speaking skills

6 Perspiration, nausea, vomiting - Listening comprehension and speaking skills

7 Vision, shortness of breath, cough - Listening comprehension and speaking skills

8 Stool, urine - Listening comprehension and speaking skills

9 Stool, urine - Listening comprehension and speaking skills

10 Heart complaints, appetite - Listening comprehension and speaking skills

11 Shivering, fever, oedema - Listening comprehension and speaking skills

12 Frequent diseases - Listening comprehension and speaking skills

13 Oesophagus, stomach, gallbladder - Listening comprehension and speaking skills

14 Bowel diseases, cardiovascular diseases - Listening comprehension and speaking skills

15 Forms of medications - Listening comprehension and speaking skills

16 Test 1

17 Types of medications - Listening comprehension and speaking skills

18 Types of medications - Listening comprehension and speaking skills

19 Instructions concerning the application of medications: oral medications - Listening comprehension and speaking skills

20 Instructions concerning the application of medications: oral medications - Listening comprehension and speaking skills

21 Instructions concerning the application of medications: drops - Listening comprehension and speaking skills

22 Instructions concerning the application of medications: creams and ointments - Listening comprehension and speaking skills

23 Prescriptions - Listening comprehension and speaking skills

24 Consolidation, Test 2.

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Exam topics/questions

http://aok.pte.hu/index.php?page=egyseg&egy_id=60&nyelv=eng&menu=okt_anyag

Participants

Dávidovics Anna (U5A10Z), Dr. Hegedűs Anita (TQQEMK), Dr. Hild Gabriella (HILSWV), Dr. Németh Tímea (X8VRGN), Dr. Rébék-

Nagy Gábor (DGOZG1), Dr. Warta Vilmos (SJYRAV), Eklicsné Dr. Lepenye Katalin (JMXXSC), Krommer Zoltán (MQ5HNA),

Kurdiné Molnár Eszter (VUCECC), Nagy Gabriella (CYMRX3), Ronczykné Berta Anikó (CJZOFU), Szalai-Szolcsányi Judit

(RBGAPH), Szántóné Dr. Csongor Alexandra (UDKY0J)

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OPF-H3A-T MEDICAL HUNGARIAN 3A - BASICS OF MEDICAL COMMUNICATION FOR STUDENTS OF

PHARMACY

Course director: GABRIELLA NAGY, language teacher

Department of Languages for Specific Purposes [email protected]

2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 3

Number of hours/semester: 0 lectures + 0 practices + 24 seminars = total of 24 hours

Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPE-H2A-T completed + OPF-H3B-T parallel

Topic

This course in devoted to the acquisition of language and communicative functions of the basic history taking process and the description

of medications.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Making up for missed classes

In the case of absences up to 25% of total class time, oral examination will have to be taken.

Reading material

- Obligatory literature

- Literature developed by the Department

Mária Győrffy: English for Doctors, Idióma Bt. Pécs, 2001 - can be purchased in the Department

- Notes

- Recommended literature

http://aok.pte.hu/index.php?page=egyseg&egy_id=60&menu=okt_anyag&nyelv=eng

Lectures

Practices

Seminars

1 Family History, social history and previous diseases

2 Family History, social history and previous diseases

3 Complaint and Pain

4 Complaint and Pain

5 Headache, dizziness

6 Perspiration, nausea, vomiting

7 Vision, shortness of breath, cough-Listening comprehension and speaking skills

8 Stool, urine

9 Stool, urine

10 Heart complaints, appetite

11 Shivering, fever, oedema

12 Frequent diseases

13 Oesophagus, stomach, gallbladder

14 Bowel diseases, cardiovascular diseases

15 Forms of medications

16 Test 1

17 Types of medications

18 Types of medications

19 Instructions concerning the application of medications: oral medications

20 Instructions concerning the application of medications: oral medications

21 Instructions concerning the application of medications: drops

22 Instructions concerning the application of medications: creams and ointments

23 Prescriptions

24 Test 2.

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Exam topics/questions

http://aok.pte.hu/index.php?page=egyseg&egy_id=60&nyelv=eng&menu=okt_anyag

Participants

Dávidovics Anna (U5A10Z), Dr. Hegedűs Anita (TQQEMK), Dr. Hild Gabriella (HILSWV), Dr. Németh Tímea (X8VRGN), Dr. Rébék-

Nagy Gábor (DGOZG1), Dr. Warta Vilmos (SJYRAV), Eklicsné Dr. Lepenye Katalin (JMXXSC), Krommer Zoltán (MQ5HNA),

Kurdiné Molnár Eszter (VUCECC), Nagy Gabriella (CYMRX3), Ronczykné Berta Anikó (CJZOFU), Szalai-Szolcsányi Judit

(RBGAPH), Szántóné Dr. Csongor Alexandra (UDKY0J)

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OPE-BKM-T BASIC METHODS OF SCIENTIFIC RESEARCH

Course director: DR. ÁGNES FARKAS, associate professor

Department of Pharmacognosy [email protected]

2 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ spring semester ▪ recommended semester: 4

Number of hours/semester: 14 lectures + 0 practices + 14 seminars = total of 28 hours

Course headcount limitations (min.-max.): 3 – 15 Prerequisites: OPA-B2E-T completed + OPA-B2G-T completed

Topic

The course aims at introducing students to the basic steps of scientific research, guiding them through stages of becoming an independent

researcher. The course covers each step of the research process, from preparing a research plan to evaluating and reporting data. Students

will become familiar with various methods of literature search, data collection, data analysis, as well as the ethical questions of scientific

research. Students will be introduced to various types of scientific works, including rules and requirements of scientific communication.

A session will be dedicated to the special requirements of writing a thesis. Emphasis will be laid on practice: in the seminars students

should put into practice what they have learned in the lectures, based on their own research work.

Conditions for acceptance of the semester

Maximum of 15 % absence allowed

Mid-term exams

Students will be required to perform some tasks related to their own research topic. The midsemester grade will be based on the successful

completion of the following tasks:

- literature search

- write a research plan

- prepare a questionnaire

- analyze data

- critically evaluate data, draw conclusions

- present results (oral and written format)

Making up for missed classes

Students can make up for absences by completing the tasks and home assignments of each class.

Reading material

- Obligatory literature

- Literature developed by the Department

Lecture materials are available at the website of the Department of Pharmacognosy.

- Notes

- Recommended literature

Turabian K. L. (2010): A Manual for Writers of Research Papers, Theses, and Dissertations. Chicago Style for Students &

Researchers. 8th edition. The University of Chicago Press. Chicago and London, pp. 448.

Lectures

1 Concept, process and strategies of scientific research. Organising research projects. Research plan.

Dr. Farkas Ágnes

2 Literature search

Dr. Farkas Ágnes

3 Methods of data collection. Questionnaires.

Dr. Farkas Ágnes

4 Designing experiments.

Dr. Farkas Ágnes

5 Data processing, data analysis.

Dr. Farkas Ágnes

6 Evaluation of data.

Dr. Farkas Ágnes

7 The role of informatics in scientific research.

Dr. Farkas Ágnes

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8 The role of informatics in scientific research.

Dr. Farkas Ágnes

9 Ethical questions of scientific research.

Dr. Farkas Ágnes

10 Animal studies. Clinical studies.

Dr. Farkas Ágnes

11 Scientific communication. Types of scientific works. Metrics of scientific achievement.

Dr. Farkas Ágnes

12 Rules and requirements in scientific communication.

Dr. Farkas Ágnes

13 Writing applications for scholarships and research grants.

Dr. Farkas Ágnes

14 Scientific co-operations. Scene and institutions of science in Hungary.

Dr. Farkas Ágnes

Practices

Seminars

1 Literature search in the field of the student’s own research I.

2 Literature search in the field of the student’s own research II.

3 Preparing a research plan based on the student’s own research objectives.

4 Preparing a questionnaire

5 Evaluation of data from the student’s research project I.

6 Evaluation of data from the student’s research project II.

7 Practice of scientific communication I.

8 Practice of scientific communication II.

9 Practice of scientific communication III.

10 Practice of scientific communication IV.

11 Practice of scientific communication V.

12 Practice of scientific communication VI.

13 Practice of writing an application for a scholarship I.

14 Practice of writing an application for a research project II.

Exam topics/questions

1. Research plan.

2. Methods of data collection.

3. Questionnaires.

4. Methods of literature search.

5. Methods of data analysis.

6. Critical evaluation of data.

7. Ethical questions of scientific research.

8. Animal studies. Clinical studies.

9. Scientific writing: types, rules and requirements.

10. References, bibliography.

11. Scene and institutions of science in Hungary.

Participants

Dr. Farkas Ágnes (DKQUBQ)

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OPE-GMO-T MODELLING THE STRUCTURE AND INTERACTIONS OF BIOACTIVE MOLECULES

Course director: DR. SÁNDOR KUNSÁGI-MÁTÉ, associate professor

Department of Pharmaceutical Chemistry [email protected]

2 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ both semesters ▪ recommended semester: 4

Number of hours/semester: 17 lectures + 11 practices + 0 seminars = total of 28 hours

Course headcount limitations (min.-max.): 4 – 20 Prerequisites: none

Topic

In this course the basic examination methods of theoretical chemistry will be discussed by the practical point of view in the frame of

following subtopics: Methods of molecular modelling. Description of the forcefield, semiempirical, ab initio and density functional

methods, advantages and disadvantages. Discovering the balance between the model ant the calculation methods. The algorithm of the

choice of appropriate model and calculation method. Short description of the basic rules and mathematical background of theoretical

chemistry. calculation of the electronic structure of atoms and molecules. Calculation the equilibrium conformations of molecules, the

role of the entropy in the interactions of bioactive molecules and its calculation. Description of the correlation between the reactivity and

the temperature. Examples at molecular level. Considering the molecular environment: explicit and implicit methods. Interesting

examples and applications in pharmacy.

Conditions for acceptance of the semester

There is no possibility to make up for a missed lecture

Mid-term exams

Two tests, each above 60 % is required for acceptance

Making up for missed classes

Upto 15% is allowed, electronical material is available

Reading material

- Obligatory literature

P.W. Atkins: Physical Chemistry

- Literature developed by the Department

Slides and notes. Scientific publications presented are also offered.

- Notes

Slides and Summaries of lectures are available electronically

- Recommended literature

Jensen_F.-Introduction_to_Computational_Chemistry_(2007)

Scientific papers, list will be given during the lectures

Lectures

1 1 lecture Experimental results raise the necessity of quantum-chemical description of the structure of materials. Quantitization

and related quantities (energy, momentum, spin). Simple mathematical descriptions.

Dr. Kunsági-Máté Sándor

2 1 lecture Experimental results raise the necessity of quantum-chemical description of the structure of materials. Quantitization

and related quantities (energy, momentum, spin). Simple mathematical descriptions.

Dr. Kunsági-Máté Sándor

3 2 lecture Axiomatic description of the quantum theory. Atomic unit system. Overview on the exact and approximative solutions

of the time - independent Schrödinger equation.

Dr. Kunsági-Máté Sándor

4 2 lecture Axiomatic description of the quantum theory. Atomic unit system. Overview on the exact and approximative solutions

of the time - independent Schrödinger equation.

Dr. Kunsági-Máté Sándor

5 3 lecture Approximative solutions: the molecular mechanics methods.

Dr. Kunsági-Máté Sándor

6 3 lecture Approximative solutions: the molecular mechanics methods.

Dr. Kunsági-Máté Sándor

7 4 lecture Semi - empirical methods, advantages and disadvantages.

Dr. Kunsági-Máté Sándor

9 5 lecture Conformation analysis, energy minimization algorithms.

Dr. Kunsági-Máté Sándor

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11 6 lecture Electronic structure of molecules. The chemical bonds, tipes of bonds. The structure of molecules, stereochemistry.

Dr. Kunsági-Máté Sándor

13 7 lecture Modelling in comparison with the experiments, calculation of the enthalpy, entropy and their appropriate experimental

values.

Dr. Kunsági-Máté Sándor

15 8 lecture Molecular symmetry, point groups and the symmetry of molecular vibrations.

Dr. Kunsági-Máté Sándor

17 9 lecture Interactions of the primycin, ergosterol and oleic acid as plasma membrane unit.

Dr. Kunsági-Máté Sándor

19 10 lecture Modelling the interactions of bioactive molecules with molecular containers in accordance with molecular packing of

drugs.

Dr. Kunsági-Máté Sándor

21 11 lecture Quantum - chemical background of the rules in atomic and molecular spectroscopy. Rules of Raman and Infrared

transitions and their relationship with the molecular symmetry.

Dr. Kunsági-Máté Sándor

23 12 lecture Effective calculation methods to consider the molecular environment: Onsager-model, Polarizable Continuum Model

Dr. Kunsági-Máté Sándor

25 13 lecture Examples: simple chemical reactions, calculation of the stability weak molecular complexes, conformation analysis.

Dr. Kunsági-Máté Sándor

27 14 lecture Examples: modelling the systems possessing high symmetry and infinite volume. Crystals and polymers.

Dr. Kunsági-Máté Sándor

Practices

4 4 practice : Geometry optimization and conformation analysis. Energy minimization algorythm mostly used in geometry

optimization practice.

Dr. Kunsági-Máté Sándor

5 5 practice: Calculation of the static potential energy surfaces of chemical reactions. Methods to determine the transition states

associated to the chemical reactions. Activation energy and activation free enthalpy.

Dr. Kunsági-Máté Sándor

6 6 practice Molecular dynamics methods, Monte-Carlo method and the Langevin model. The implicite consideration of the

molecular environment.

Dr. Kunsági-Máté Sándor

7 7 practice Modelling the elementary chemical reactions. Calculation of molecular dynamics. Determination of the rection rate

using direct trajectory method.

Dr. Kunsági-Máté Sándor

8 8 practice Methods for consideration of the solvents: the Onsager-model, and the Polarizable Continuum Model, PCM. Explicit

consideration of the solvent molecules. The TIP3P model.

Dr. Kunsági-Máté Sándor

9 9 practice Calculation of molecular parameters have significant importance in the practice. The QSAR and the molecular

similarity - analysis.

Dr. Kunsági-Máté Sándor

10 10 practice Examples: conformation analysis, bong length, bond angle and dihedral angles. The bipyridile and thionine molecules.

Calixarenes and stereoisomers. Importance of hydrogen bonds in the stability of molecular geometries.

Dr. Kunsági-Máté Sándor

11 11 practice Examples: interactions of molecules. Calculation of the host - guest interactions, calculations of interactions of

calixarenes with neutral molecules based on pi-pi interactions.

Dr. Kunsági-Máté Sándor

12 12 practice Examples : elementary dissociation reactions: dissociation of asymmetric olefines. Effect of melecular environment

on the reaction rate.

Dr. Kunsági-Máté Sándor

13 13 practice Examples: Interaction of Primycin and oleic acid. Calculation of the interaction energy in system possessing large

numbers of electrons.

Dr. Kunsági-Máté Sándor

14 14 practice E+xamples: dynamic processes: modelling the crystal growth.

Dr. Kunsági-Máté Sándor

Seminars

Exam topics/questions

Methods of molecular modelling. Description of the forcefield, semiempirical, ab initio and density functional methods, avantages and

disadvantages. The balance between the model ant the calculation methods. The algorithm of the choice of appropriate model and

calculation method.Short description of the basic rules and mathematical background of theoretical chemistry. calculation of the

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electronic structure of atoms and molecules. Calculation the equilibrium conformations of molecules, the role of the entropy in the

interactions of bioactive molecules and its calculation. Description of the correlation between the reactivity and the temperature.

Examples at moecular level. Considering the molecular environment: explicit and implicit methods. Interesting examples and

applications in pharmacy.

Participants

Dr. Kunsági-Máté Sándor (UYZM2Q)

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OPE-SME-T SPECTROMETRIC IDENTIFICATION OF ORGANIC COMPOUNDS

Course director: DR. CECILIA PÁPAY- SÁR, associate professor

Department of Organic and Pharmacological Chemistry [email protected]

2 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ spring semester ▪ recommended semester: 4

Number of hours/semester: 0 lectures + 0 practices + 24 seminars = total of 24 hours

Course headcount limitations (min.-max.): 2 – 10 Prerequisites: OPA-S1E-T completed

Topic

The aim of this course is to introduce the students how to identify organic compounds from the complementary information afforded by

three types of spectra: infrared, mass and NMR.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

The student who has been absent from more than 25 % of the classes cannot be granted to entry of exam.

Making up for missed classes

Students can personally consult with the lecturer.

Reading material

- Obligatory literature

Silverstein, R.M., Webster, F.X., Kiemle, D.: Spectrometric Identification of Organic Compounds, John Wiley and Sons, 2005.

- Literature developed by the Department

- Notes

- Recommended literature

Lectures

Practices

Seminars

1 Infrared Spectroscopy: Introduction, theory, instrumentation, interpretation of spectra

2 Infrared Spectroscopy: Introduction, theory, instrumentation, interpretation of spectra

3 Infrared Spectroscopy: Characteristic group absorptions of organic molecules

4 Infrared Spectroscopy: Characteristic group absorptions of organic molecules

5 Infrared Spectroscopy: Solving problems

6 Infrared Spectroscopy: Solving problems

7 Proton Magnetic Resonance Spectrometry (1H NMR): Introduction, theory, instrumentation

8 Proton Magnetic Resonance Spectrometry (1H NMR): Introduction, theory, instrumentation

9 1H NMR: Chemical shift, simple spin coupling

10 1H NMR: Chemical shift, simple spin coupling

11 1H NMR: Protons on heteroatoms, chemical shift equivalence and magnetic equivalence, effects of a chiral center

12 1H NMR: Protons on heteroatoms, chemical shift equivalence and magnetic equivalence, effects of a chiral center

13 13 C NMR Spectroscopy: Interpretation of 13 C spectra. The principles of MRI

14 1H NMR and 13 C NMR: Solving problems

15 Mass Spectrometry: Mass spectrometer parts, ionization processes

16 Mass Spectrometry: Mass spectrometer parts, ionization processes

17 Mass Spectrometry: Appearance of the mass spectrum, mass spectra of classes of organic compounds

18 Mass Spectrometry: Appearance of the mass spectrum, mass spectra of classes of organic compounds

19 Mass Spectrometry: Interpretation of the mass spectrum through examples

20 Mass Spectrometry: Interpretation of the mass spectrum through examples

21 Summary of spectroscopic methods: identification of organic molecules from IR, NMR and mass spectra

22 Summary of spectroscopic methods: identification of organic molecules from IR, NMR and mass spectra

23 Summary of spectroscopic methods: identification of organic molecules from IR, NMR and mass spectra

24 Evaluation, written test

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Exam topics/questions

Infrared Spectroscopy: theory, instrumentation, interpretation of spectra, chacteristic group absorptions of organic molecules.

Proton Magnetic Resonance Spectrometry (1H NMR): theory, instrumentation, chemical shift, simple spin coupling, protons on

heteroatoms, chemical shift equivalence and magnetic equivalence, effects of a chiral center.

Mass Spectrometry: mass spectrometer parts, ionization processes, appearance of the mass spectrum, mass spectra of classes of organic

compounds.

Identification of simple organic molecules from IR, NMR and mass spectra.

Participants

Dr. Kálai Tamás (BDF5M9), Dr. Pápayné Dr. Sár Cecilia (BTYFJX)

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OPE-TIZ-T CENTRAL REGULATION OF FEEDING AND METABOLISM. NEW APPROACHES

Course director: DR. ZOLTÁN KARÁDI, professor

Institute of Physiology [email protected]

1 credit ▪ midsemester grade ▪ Elective subject for the Medical-biological module ▪ spring semester ▪ recommended semester: 4

Number of hours/semester: 12 lectures + 0 practices + 0 seminars = total of 12 hours

Course headcount limitations (min.-max.): 2 – 25

Prerequisites: OPO-AI2-T completed + OPO-H1E-T completed + OPO-G1B-T parallel

The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

The high incidence and costs of eating and metabolic disorders make it indispensable to experimentally test new theoretical

considerations, and to employ their conclusive results in basically new clinical protocols. Students at early stage of their studies are, thus,

encouraged to familiarize with new theoretical aspects and experimental findings.

Neural and humoral mechanisms in the central feeding control and metabolic regulation. Body weight control in health and disease.

Peripheral and central taste information processing; gustation in the central regulation of food and fluid intake. Obesity, diabetes mellitus

and the metabolic syndrome: New interpretations.

Conditions for acceptance of the semester

According to general regulations

Mid-term exams

Individual oral mid-semester test.

Making up for missed classes

Individually discussed

Reading material

- Obligatory literature

Guyton & Hall: Textbook of Medical Physiology, Saunders

- Literature developed by the Department

- Notes

- Recommended literature

Williams and Pickup: Handbook of Diabetes, Blackwell

Doty: Handbook of Olfaction and Gustation, Marcel Dekker

Lectures

1 Physiological significance of food and fluid intake, and metabolism. Homeostasis, motivation.

Dr. Karádi Zoltán

2 Neuronal and humoral factors in the central regulation of homeostatic functions: brain centers, neurotransmitter pathways,

neuropeptides. I

Dr. Karádi Zoltán

3 Neuronal and humoral factors in the central regulation of homeostatic functions: brain centers, neurotransmitter pathways,

neuropeptides. II

Dr. Karádi Zoltán

4 Neuronal and humoral factors in the central regulation of homeostatic functions: brain centers, neurotransmitter pathways,

neuropeptides. III

Dr. Karádi Zoltán

5 Exogenous chemosensory modalities. Physiologic roles of gustation.

Dr. Karádi Zoltán

6 Central taste pathways, „labeled lines”, neurons.

Dr. Karádi Zoltán

7 Taste preference, taste aversion, palatability, flavour.

Dr. Karádi Zoltán

8 The glucose-monitoring (GM) neural network. I

Dr. Karádi Zoltán

9 The glucose-monitoring (GM) neural network. II

Dr. Karádi Zoltán

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10 Eating and metabolic disorders: obesity, anorexia nervosa, diabetes mellitus, metabolic syndrome. I

Dr. Karádi Zoltán

11 Eating and metabolic disorders: obesity, anorexia nervosa, diabetes mellitus, metabolic syndrome. II

Dr. Karádi Zoltán

12 Feeding and metabolic disorders: disturbance of the GM system?

Dr. Karádi Zoltán

Practices

Seminars

Exam topics/questions

1. Feeding (hunger) and satiety centers; feeding (hunger) and satiety neural pathways.

2. Orexigenic and anorexigenic neuromodulator factors (list up at least 3 of each).

3. The two major neuron types of the hypothalamic arcuate nucleus (with respect to feeding); their modulation by insulin, leptin, and

ghrelin.

4. Key structures of the central glucose-monitoring neuronal network (list up at least 4 of them).

5. Consequences of selective destruction of central GM neurons (name of the toxic agent, and its effects).

Participants

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OPF-QBI-T QUANTUM BIOLOGY: QUANTUM PHENOMENA IN BIOLOGICAL PROCESSES

Course director: DR. KRISZTIÁN KVELL, associate professor

Department of Pharmaceutical Biotechnology [email protected]

2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 4

Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours

Course headcount limitations (min.-max.): 3 – 50 Prerequisites: OPO-G2B-T completed

Topic

Course description:

Based on common scientific approach quantum phenomena are not relevant in biological processes. The living cell has relatively large

dimensions, is filled with hydrated vibrating macromolecules, and follows the rules thermodynamics rather than quantum mechanics.

Yet, besides attractive theories, experimental data also accumulate suggesting that living cells readily exploit quantum phenomena.

Several biological processes require quantum biology approach for full understanding. These include photosynthesis, various enzyme

activities, DNA mutation accumulation, avian magnetoreception, mammalian olfaction etc. During the course students get familiar with

the quantum biology explanation of these biological processes.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

There will be several occasions for the students to rewrite midterm tests.

Making up for missed classes

Students will get e-learning material to cope to follow the course at home.

Reading material

- Obligatory literature

Life on the edge: The coming of age of quantum biology, Johnjoe McFadden, Jim Al-Khalili, Broadway Books (2016) 368 pages,

ISBN-13: 978-0307986825

- Literature developed by the Department

Topics:

- Quantum phenomena and basics terms

- Thermodynamics vs quantum mechanics

- Structural characteristics of biological macromolecules

- Quantum biology approach of the living cell

- Quantum biology approach of cell death

- Quantum biology approach of molecular energy transport

- Quantum biology approach of genetic mutation accumulation

- Quantum biology approach of photosynthesis

- Quantum biology approach of enzyme activity

- Quantum biology approach of avian magnetoreception

- Quantum biology approach of mammalian olfaction

- Quantum biology approach of the conscious mind

- Basic principles of quantum computers and quantum biology analogies

- Written exam

- Notes

Life on the edge: The coming of age of quantum biology, Johnjoe McFadden, Jim Al-Khalili, Broadway Books (2016) 368 pages,

ISBN-13: 978-0307986825

- Recommended literature

Life on the edge: The coming of age of quantum biology, Johnjoe McFadden, Jim Al-Khalili, Broadway Books (2016) 368 pages,

ISBN-13: 978-0307986825

Lectures

1 Quantum phenomena and basics terms I.

Dr. Lukács András Szilárd

2 Quantum phenomena and basics terms II.

Dr. Lukács András Szilárd

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3 Thermodynamics vs quantum mechanics I.

Dr. Lukács András Szilárd

4 Thermodynamics vs quantum mechanics II.

Dr. Lukács András Szilárd

5 Structural characteristics of biological macromolecules I.

Dr. Kvell Krisztián

6 Structural characteristics of biological macromolecules II.

Dr. Kvell Krisztián

7 Quantum biology approach of the living cell I.

Dr. Ábrahám István Miklós

8 Quantum biology approach of the living cell II.

Dr. Ábrahám István Miklós

9 Quantum biology approach of cell death I.

Dr. Ábrahám István Miklós

10 Quantum biology approach of cell death II.

Dr. Ábrahám István Miklós

11 Quantum biology approach of molecular energy transport I.

Dr. Pál Szilárd

12 Quantum biology approach of molecular energy transport II.

Dr. Pál Szilárd

13 Quantum biology approach of genetic mutation accumulation I.

Dr. Kvell Krisztián

14 Quantum biology approach of genetic mutation accumulation II.

Dr. Kvell Krisztián

15 Written exam

Dr. Kvell Krisztián

16 Quantum biology approach of photosynthesis I.

Dr. Hoffmann Gyula

17 Quantum biology approach of photosynthesis II.

Dr. Hoffmann Gyula

18 Quantum biology approach of enzyme activity I.

Dr. Pál Szilárd

19 Quantum biology approach of enzyme activity II.

Dr. Pál Szilárd

20 Quantum biology approach of avian magnetoreception I.

Dr. Hoffmann Gyula

21 Quantum biology approach of avian magnetoreception II.

Dr. Hoffmann Gyula

22 Quantum biology approach of mammalian olfaction I.

Dr. Hoffmann Gyula

23 Quantum biology approach of mammalian olfaction II.

Dr. Hoffmann Gyula

24 Quantum biology approach of the conscious mind I.

Dr. Sik Attila Gábor

25 Quantum biology approach of the conscious mind II.

Dr. Sik Attila Gábor

26 Basic principles of quantum computers and quantum biology analogies I.

Dr. Kvell Krisztián

27 Basic principles of quantum computers and quantum biology analogies II.

Dr. Kvell Krisztián

28 Written exam

Dr. Kvell Krisztián

Practices

Seminars

Exam topics/questions

https://www.dropbox.com/home/munka/Kvantumbiológia?preview=LifeOnTheEdge2014.pdf

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Participants

Dr. Ábrahám István Miklós (HQI9FH), Dr. Hoffmann Gyula (JB4TQB), Dr. Kvell Krisztián (Y0GLOV), Dr. Lukács András Szilárd

(LZ2I4Q), Dr. Miskei György Zsolt (PTAG3C), Dr. Pál Szilárd (FYF5E9), Dr. Sik Attila Gábor (A12OXW)

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OPF-GMI-T GYÓGYSZERÉSZEK A MINDENNAPOKBAN - ANGOL VÁLTOZAT

Course director: DR. ÁGNES FARKAS, associate professor

Department of Pharmacognosy [email protected]

1 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 4

Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours

Course headcount limitations (min.-max.): 3 – 30 Prerequisites: none

Topic

This course intends to provide insight into various career opportunities for graduates with a degree in pharmacy. Invited speakers working

in various fields of the pharmaceutical profession talk about characteristic features of their job, including daily routine, challenging

situations and peculiarities they have come accross. Speakers represent pharmacists working in community pharmacies, clinical

pharmacies, in the pharmaceutical industry, as well as at health authorities and at universities or research institutes.

Conditions for acceptance of the semester

Maximum of 15 % absence allowed

Mid-term exams

Active participation is expected from students. They should be prepared to ask questions from each speaker and they are requested to

take notes on each occasion. These notes should be handed in to the course instructor at the end of each class.

The final grade is based on students’ activity in class and the written notes they have taken on each occassion.

Making up for missed classes

There is no opportunity to make up for absences, since different speakers are invited to each class.

Reading material

- Obligatory literature

None

- Literature developed by the Department

- Notes

- Recommended literature

Lectures

1 Invited speaker. Pharmacist at a community pharmacy.

Dr. Farkas Ágnes

2 Invited speaker. Pharmacist at a community pharmacy.

Dr. Farkas Ágnes

3 Invited speaker. Pharmacist at a clinical pharmacy.

Dr. Lankó Erzsébet

4 Invited speaker. Pharmacist at a clinical pharmacy.

Dr. Lankó Erzsébet

5 Invited speaker. Pharmacist working in the pharmaceutical industry.

Dr. Farkas Ágnes

6 Invited speaker. Pharmacist working in the pharmaceutical industry.

Dr. Farkas Ágnes

7 Invited speaker. Pharmacist working at a university.

Dr. Poór Miklós

8 Invited speaker. Pharmacist working at a university.

Dr. Poór Miklós

9 Invited speaker. Pharmacist working in a research institute.

Dr. Farkas Ágnes

10 Invited speaker. Pharmacist working in a research institute.

Dr. Farkas Ágnes

11 Invited speaker. Pharmacist working at the health authorities.

Dr. Kuzma Mónika

12 Invited speaker. Pharmacist working at the health authorities.

Dr. Kuzma Mónika

13 Invited speaker. Daily routine of a specialty pharmacist.

Dr. Szabóné Dr. Schirm Szilvia

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14 Invited speaker. Daily routine of a specialty pharmacist.

Dr. Szabóné Dr. Schirm Szilvia

Practices

Seminars

Exam topics/questions

No exam questions.

Participants

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OPF-H4A-T MEDICAL HUNGARIAN 4A - BASICS OF MEDICAL COMMUNICATION FOR STUDENTS OF

PHARMACY

Course director: GABRIELLA NAGY, language teacher

Department of Languages for Specific Purposes [email protected]

2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 4

Number of hours/semester: 0 lectures + 0 practices + 24 seminars = total of 24 hours

Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPF-H3A-T completed + OPF-H4B-T parallel

Topic

This course provides language and communicative functions in the areas of medications, the application of medications and prescribing

medications and is also meant to give opportunities for putting skills and knowledge into practice in preparation for the final exam.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

--

Making up for missed classes

In the case of absences up to 25% of total class time, oral examination will have to be taken.

Reading material

- Obligatory literature

- Literature developed by the Department

Hand-outs

- Notes

- Recommended literature

Lectures

Practices

Seminars

1 Types and forms of medications - Review

2 Application of medications - Review

3 Instructions concerning the use of medications: pain relievers

4 Instructions concerning the use of medications: pain relievers

5 Instructions concerning the use of medications: antipyretics

6 Instructions concerning the use of medications: cough medications

7 Instructions concerning the use of medications: antidiabetics

8 Instructions concerning the use of medications: spasmolytics

9 Instructions concerning the use of medications: sleeping pills

10 Instructions concerning the use of medications: steroids

11 Instructions concerning the use of medications: antibiotics

12 Instructions concerning the use of medications: antiinflammatory medications

13 Instructions concerning the use of medications: emetics and antiemetics

14 Instructions concerning the use of medications: eye, ear and nasal drops

15 Instructions concerning the use of medications: medications applied to the skin

16 Test 1

17 Instructions concerning the use of medications: suppository

18 First aid instruments

19 Preparation for the Final Exam in Medical Hungarian

20 Preparation for the Final Exam in Medical Hungarian

21 Preparation for the Final Exam in Medical Hungarian

22 Preparation for the Final Exam in Medical Hungarian

23 Preparation for the Final Exam in Medical Hungarian

24 Test 2. Course evaluation

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Exam topics/questions

http://aok.pte.hu/index.php?page=egyseg&egy_id=60&nyelv=eng&menu=okt_anyag

Participants

Dávidovics Anna (U5A10Z), Dr. Hegedűs Anita (TQQEMK), Dr. Hild Gabriella (HILSWV), Dr. Németh Tímea (X8VRGN), Dr. Rébék-

Nagy Gábor (DGOZG1), Dr. Warta Vilmos (SJYRAV), Eklicsné Dr. Lepenye Katalin (JMXXSC), Krommer Zoltán (MQ5HNA),

Kurdiné Molnár Eszter (VUCECC), Nagy Gabriella (CYMRX3), Ronczykné Berta Anikó (CJZOFU), Szalai-Szolcsányi Judit

(RBGAPH), Szántóné Dr. Csongor Alexandra (UDKY0J)

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OPF-H4B-T MEDICAL HUNGARIAN 4B - MEDICAL COMMUNICATION IN PRACTICE FOR STUDENTS OF

PHARMACY

Course director: GABRIELLA NAGY, language teacher

Department of Languages for Specific Purposes [email protected]

2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 4

Number of hours/semester: 0 lectures + 0 practices + 24 seminars = total of 24 hours

Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OPF-H3B-T completed + OPF-H4A-T parallel +

Topic

This course provides language and communicative functions in the areas of medications, the application of medications and prescribing

medications and is also meant to give opportunities for putting skills and knowledge into practice in preparation for the final exam.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Making up for missed classes

In the case of absences up to 25% of total class time, oral examination will have to be taken.

Reading material

- Obligatory literature

- Literature developed by the Department

Hand-outs

- Notes

- Recommended literature

Lectures

Practices

Seminars

1 Types and forms of medications - Review

2 Application of medications - Review

3 Instructions concerning the use of medications: pain relievers - Pharmacist-patient dialogues

4 Instructions concerning the use of medications: pain relievers- Pharmacist-patient dialogues

5 Instructions concerning the use of medications: antipyretics- Pharmacist-patient dialogues

6 Instructions concerning the use of medications: cough medications- Pharmacist-patient dialogues

7 Instructions concerning the use of medications: antidiabetics- Pharmacist-patient dialogues

8 Instructions concerning the use of medications: spasmolytics- Pharmacist-patient dialogues

9 Instructions concerning the use of medications: sleeping pills- Pharmacist-patient dialogues

10 Instructions concerning the use of medications: steroids- Pharmacist-patient dialogues

11 Instructions concerning the use of medications: antibiotics- Pharmacist-patient dialogues

12 Instructions concerning the use of medications: antiinflammatory medications- Pharmacist-patient dialogues

13 Instructions concerning the use of medications: emetics and antiemetics- Pharmacist-patient dialogues

14 Instructions concerning the use of medications: eye, ear and nasal drops- Pharmacist-patient dialogues

15 Instructions concerning the use of medications: medications applied to the skin- Pharmacist-patient dialogues

16 Test 1

17 Instructions concerning the use of medications: suppository- Pharmacist-patient dialogues

18 First aid instruments

19 Preparation for the Final Exam in Medical Hungarian

20 Preparation for the Final Exam in Medical Hungarian

21 Preparation for the Final Exam in Medical Hungarian

22 Preparation for the Final Exam in Medical Hungarian

23 Preparation for the Final Exam in Medical Hungarian

24 Test 2. Course evaluation

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Exam topics/questions

http://aok.pte.hu/index.php?page=egyseg&egy_id=60&nyelv=eng&menu=okt_anyag

Participants

Dávidovics Anna (U5A10Z), Dr. Hegedűs Anita (TQQEMK), Dr. Hild Gabriella (HILSWV), Dr. Németh Tímea (X8VRGN), Dr. Rébék-

Nagy Gábor (DGOZG1), Dr. Warta Vilmos (SJYRAV), Eklicsné Dr. Lepenye Katalin (JMXXSC), Krommer Zoltán (MQ5HNA),

Kurdiné Molnár Eszter (VUCECC), Nagy Gabriella (CYMRX3), Ronczykné Berta Anikó (CJZOFU), Szalai-Szolcsányi Judit

(RBGAPH), Szántóné Dr. Csongor Alexandra (UDKY0J)

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OPF-HB2-T HOW TO ACHIEVE BETTER GRADE IN ORGANIC CHEMISTRY 2

Course director: DR. BALÁZS BOGNÁR, assistant professor

Department of Organic and Pharmacological Chemistry [email protected]

1 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 4

Number of hours/semester: 0 lectures + 0 practices + 10 seminars = total of 10 hours

Course headcount limitations (min.-max.): 2 – 20 Prerequisites: OPA-S2E-T parallel + OPA-S1E-T completed

Topic

The aim of the course is to help the students to understand the important reaction mechanisms, and find the connections between the

different topics.

1. Revision of addition and substitution reactions

2. Basicity and reactivity of amines

3-4. Reactions of carbonyl compounds, nucleophilic additions, condensations

5. Isomerisations in carbohydrates

6. 1. test

7. Acidity of carboxylic acids

8. Reactions of carboxylic acids and their derivatives

9. Aromatic substitutions of heteroaromatics

10. 2. test

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Nincs.

Making up for missed classes

Nincs.

Reading material

- Obligatory literature

- Literature developed by the Department

The worksheets will be granted on the seminar.

- Notes

- Recommended literature

Estelle K. Meislich; Herbert Meislich; Jacob Sharefkin: Schaum’s Series 3000 Solved Problems In Organic Chemistry, McGraw-

Hill, Inc., New York, 1994.

T. W. Graham Solomons: Organic Chemistry, 7th edition, Wiley and Sons, New York, 2000.

John McMurry, Eric Simanek: Fundamentals of Organic Chemistry, 6th edition, Thomson Brooks/Cole, Belmont, 2007.

Lectures

Practices

Seminars

1 Revision of the most important reaction mechanisms from the 1. semester: addition and substitution reactions.

2 Basicity, synthesis and reactions of amines.

3 Reactions of carbonyl compounds, nucleophilic additions, condensations with S,- N,- O-nucleophiles.

4 Reactions of carbonyl compounds, nucleophilic additions, condensations with C-nucleophiles.

5 Isomerisations and reactions in carbohydrates.

6 1. test: amines, aldehydes, ketons, carbohydrates.

7 Acidity and reactions of carboxylic acids.

8 Reactions of carboxylic acids and their derivatives (amides, esters anhydrides).

9 Aromatic nucleophilic and electrophilic substitutions of heteroaromatics.

10 2. test: carboxylic acids and its derivatives, heterocycles.

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Exam topics/questions

There is no exam.

Participants

Dr. Bognár Balázs (U34DM4)

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OPF-VAN-T IRON METABOLISM: FROM MOLECULAR MECHANISMS TO CLINICAL CONSEQUENCES

Course director: DR. EDINA PANDUR, assistant professor

Department of Pharmaceutical Biology [email protected]

2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 4

Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours

Course headcount limitations (min.-max.): 4 – 30 Prerequisites: OPO-G2B-T completed

Topic

During the course we will discuss the role of iron in the metabolism. We will deal with the iron demand of microorganisms and with the

role of iron in the protective mechanisms against bacterial infections. We will discuss the possibilities of iron uptake and intracellular

iron utilistaion, especially heme synthesis, and the syntesis of iron-sulfur clusters. The iron storage and iron mobilization from stores will

be discussed in details. We reveal the functions of iron regulatory factors, their crosstalks, and the functions of the iron-containing

proteins. Based on the brand new literature we discuss the the positive and negative regulators of the master iron regulator hepcidin.

During the course we will deal with the different types of iron disorders and diseases (anemias, thalassemias, secondary iron overload,

hemochromatosis) their genetic background, and therapeutic approaches. Based on the most actual findings the role of iron in the

developpment of neurodegenerative diseases (Parkinson’s disease, Alzheimer’s disease and Huntington’s disease) will be also discussed.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

One midterm exam, one possibility for retake.

Making up for missed classes

Personal consultation

Reading material

- Obligatory literature

- Literature developed by the Department

The lectures will be uploaded to the Neptun Meet street.

- Notes

- Recommended literature

Robert Crichton: Iron metabolism 4th Edition

Sarika Arora: Iron metabolism

Lectures

1 Solution chemistry of iron

Jánosa Gergely

2 Interactions between iron other metal ion

Jánosa Gergely

3 The Importance of Iron for Biological Systems: haemoproteins, iron-sulfur proteins, other iron containing proteins

Pandur Edina Dr.

4 Microbial Iron Transport and Metabolism

Poór Viktor Soma Dr.

5 Iron Acquisition by pathogens

Poór Viktor Soma Dr.

6 Iron metabolism of yeasts

Pap Ramóna

7 Iron uptake by plants

Pandur Edina Dr.

8 Iron homeostasis in plants

Pandur Edina Dr.

9 Cellular Iron Uptake and Export in Mammals: iron transporters

Pandur Edina Dr.

10 Mammalian intestinal iron absorption

Pandur Edina Dr.

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11 Intracellular Iron Storage

Pandur Edina Dr.

12 Intracellular Iron Metabolism and Cellular Iron Homeostasis I: Labile iron pool, mitochondrial iron uptake and metabolism haem

biosynthesis

Pap Ramóna

13 Intracellular Iron Metabolism and Cellular Iron Homeostasis II: synthesis of iron-sulfur clusters, functions of iron responsive

elements and iron regulatory proteins

Pap Ramóna

14 Regulation of Systemic Iron Metabolism: positive regulators of hepcidin

Pandur Edina Dr.

15 Regulation of Systemic Iron Metabolism: negative regulators of hepcidin

Pandur Edina Dr.

16 Pathophysiology of Iron metabolism: anemias (IDA, IRIDA, ACD)

Jánosa Gergely

17 Pathophysiology of Iron metabolism: thalassemias and secondary iron overload

Pandur Edina Dr.

18 Pathophysiology of Iron metabolism: hemochromatosis

Pandur Edina Dr.

19 Pathophysiology of Iron metabolism: therapeutic approaches

Pandur Edina Dr.

20 Iron disorders and Laboratory parameters 1.

Nagy Tamás Dr. II

21 Iron disorders and Laboratory parameters 2.

Nagy Tamás Dr. II

22 Iron and oxidative stress

Pandur Edina Dr.

23 Iron and immunity 1.

Pap Ramóna

24 Iron and immunity 2

. Pap Ramóna

25 Brain iron metabolism

Pandur Edina Dr.

26 The role of iron in neurodegenerative diseases

Pandur Edina Dr.

27 Iron and cancer 1.

Pandur Edina Dr.

28 Iron and cancer 2.

Pandur Edina Dr.

Practices

Seminars

Exam topics/questions

The questions will be formed from the learning material of the lectures.

Participants

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OPF-SKI-T BASICS OF CHEMICAL INFORMATICS

Course director: DR. GYŐZŐ KORNÉL KULCSÁR, assistant professor

Department of Pharmaceutical Chemistry [email protected]

1 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 4

Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours

Course headcount limitations (min.-max.): 3 – 15 Prerequisites: OPA-S1E-T completed

Topic

The aim of the course is to give the students a basic knowledge of chemical informatics. An overview of how computers have become

the indispensable tools for chemical experiments, measurements, regulatory and performance evaluation tasks, and theoretical chemistry

tests.

We cover the chemical sciences from used software, web resources, which we believe are most useful during academic years in chemical

science student work and in preparing theses. Students can learn the basics of molecular modeling, the use of databases available in the

University (ScienceDirect, PubMed, SciFinder ...), the general steps of the search.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation in the lectures is obligatory.

Maximum three absences can be accepted.

Making up for missed classes

There is no opportunity to make up missed classes.

Reading material

- Obligatory literature

- Literature developed by the Department

The worksheets will be handed on the seminars.

- Notes

- Recommended literature

https://docs.chemaxon.com/display/docs/MarvinSketch+User%27s+Guide

http://www.cambridgesoft.com/support/DesktopSupport/Documentation/Manuals/files/chemdraw_9_english.pdf

Lectures

1 Introduction, simple database managers (literature, citations, etc.) in chemistry.

Dr. Kulcsár Győző Kornél

2 Introduction into the Molecular Modeling Software”s

Dr. Kulcsár Győző Kornél

3 Molecular modeling - structural fundamentals

Dr. Kulcsár Győző Kornél

4 Molecular modeling - structure optimization

Dr. Kulcsár Győző Kornél

5 Molecular modeling - molecules and interaction with the surroundings

Dr. Kulcsár Győző Kornél

6 Molecular modeling - molecular Interactions

Dr. Kulcsár Győző Kornél

7 Molecular modeling - applied modeling in drug research

Dr. Kulcsár Győző Kornél

8 Chemical databases I.

Dr. Kulcsár Győző Kornél

9 Chemical databases II.

Dr. Kulcsár Győző Kornél

10 Using a text editor application in chemistry

Dr. Kulcsár Győző Kornél

11 Handling bibliography

Dr. Kulcsár Győző Kornél

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12 Apply a spreadsheet program in chemistry

Dr. Kulcsár Győző Kornél

13 Apply a vector drawing program. Creating a flowchart of science, chemical content and flow charts. Photos and videos in

chemistry, the basics of image processing.

Dr. Kulcsár Győző Kornél

14 Presentation of student results, evaluation of the semester

Dr. Kulcsár Győző Kornél

Practices

Seminars

Exam topics/questions

Written test covering the topics of the lectures.

Participants

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OPF-CSU-T MIRACLES OF LIVING MATERIALS ("REALISTIC" BIOCHEMISTRY)

Course director: DR. BALÁZS VERES, associate professor

Department of Biochemistry and Medical Chemistry [email protected]

1 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 4

Number of hours/semester: 12 lectures + 0 practices + 0 seminars = total of 12 hours

Course headcount limitations (min.-max.): 5 – 45 Prerequisites: none

The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

The aim of the course is to enlighten and uncover the biochemical background of those topics which are selected as recent „mainstream”

natural science issues. The topic spectrum is wide enough to cover problems from synthetic biology through dopes in sport until toxins

and poisons of plants, fungi and animals. There is a special session about the physical, chemical and medical Nobel prizes from the last

decade to get insight to the hottest fields of natural sciences.

Conditions for acceptance of the semester

Maximum of 15 % absence allowed

Mid-term exams

Making up for missed classes

There is no possibility to make up.

Reading material

- Obligatory literature

- Literature developed by the Department

Lecture slides (in pdf format) will be available for the students. WEB links and additional on line materials will be included as well.

- Notes

Lecture slides (in pdf format) will be available for the students. WEB links and additional on line materials will be included as well.

- Recommended literature

Lecture slides (in pdf format) will be available for the students. WEB links and additional on line materials will be included as well.

Lectures

1 Human genome project, gene therapy, epigenetics

Dr. Veres Balázs

2 DNA sequencing, PCR, CSI

Dr. Veres Balázs

3 Playing God: synthetic biology

Dr. Veres Balázs

4 You are what you eat: GMO

Dr. Veres Balázs

5 Superman: doping in sport and brain doping

Dr. Veres Balázs

6 Dependence: biochemistry of alcohol and drugs

Dr. Veres Balázs

7 Falling down: apoptosis, necrosis, autophagy

Dr. Veres Balázs

8 Cancer, AIDS: beyond therapy

Dr. Veres Balázs

9 Biochemistry of neurodegenerative disorders

Dr. Veres Balázs

10 Antibiotics: past, present, future

Dr. Veres Balázs

11 Home delivery: nanoparticles, liposomes

Dr. Veres Balázs

12 Nature strikes back: toxins of plants, fungi and animals

Dr. Veres Balázs

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Practices

Seminars

Exam topics/questions

Exam topics are the topics of the lectures during the course.

Participants

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OPF-TG2-T STUDENT PROJECT RESEARCH FOR STUDENTS OF PHARMACEUTIST PROGRAMME 2

Course director: DR. GYÖRGYI HORVÁTH, associate professor

Department of Pharmacognosy [email protected]

2 credit ▪ midsemester grade ▪ Optional subject for the Pharm. theor. and pract. skills module ▪ spring semester ▪ recommended semester: 4

Number of hours/semester: 0 lectures + 24 practices + 0 seminars = total of 24 hours

Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPF-TG1-T completed

Topic

The course aims at promoting of students to make student research projects on the field of pharmaceutical sciences. Furthermore, we

wish to give individual possibilities of students to perform experiments in the different pharmaceutical institutes involved into Students’

Research Society.

Conditions for acceptance of the semester

The continuous student’s work is recommended. The continuous enrollment of consecutive courses can be stopped and continued in

further semesters.

The prerequisite of this course (TDK 2): registration of the student in the database of Students’ Research Society and the fulfillment of

the Student Project Research for Students of Pharmaceutist Programme 1 course.

Mid-term exams

- Introduction of conference abstract or conference manuscript (student is co-author) for the course supervisor at the end of 13th week of

the semester.

- Written report on the work performed by the student. It must be sent to the course supervisor at the end of 13th week of the semester.

- Among the two conditions, one of them should be made at least.

Making up for missed classes

There is no possibility.

Reading material

- Obligatory literature

- Literature developed by the Department

- Notes

- Recommended literature

ScienceDirect database

Lectures

Practices

1-24 Research.

Seminars

Exam topics/questions

Not applicable.

Participants

Dr. Horváth Györgyi (GDLTCH)

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OPE-EFA-T ETHNOPHARMACOBOTANY

Course director: DR. NÓRA PAPP, associate professor

Department of Pharmacognosy [email protected]

2 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ autumn semester ▪ recommended semester: 5

Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours

Course headcount limitations (min.-max.): 4 – 20 Prerequisites: OPO-G1E-T completed + OPO-G2E-T completed

The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

Several written sources are available on the ethnobotanical usage and pharmaceutical history of medicinal plants from the Ancient Times.

The course presents a summary about ethnobotanical data focusing on folk therapeutical methods and values of the Mediterranean area,

Transylvania, countries of Europe, Asia, America and Africa completed by the scientific activity and curriculum vitae of ethnobotanists

and researchers in this topic. Students receive a general approach about the rules and regularity of the special folk terminology, practice,

folk customs and symbols in consideration of medicinal plants. In addition to ethnobotanical methods, the actual state, position and

necessity of surveys are discussed during the course.

Conditions for acceptance of the semester

Satisfactory fulfilment of 2 written tests based on the lectures.

Absences: according to the Code of Studies and Examinations of the Medical School.

Mid-term exams

The required 2 tests can be retaken or corrected in the course.

Making up for missed classes

Downloading lectures.

Reading material

- Obligatory literature

- Literature developed by the Department

http://aok.pte.hu/en/egyseg/oktatasianyagok/1640

http://gytk.pte.hu/en/egyseg/oktatasianyagok/1640

- Notes

- Recommended literature

Cunninham A. B.: Applied Ethnobotany. People, Wild Plant Use and Conservation, Earthscan, London, 2002

Ellen, Davi E., Hatfield, G.: Medicinal Plants in Folk Tradition an Ethnobotany of Britain and Ireland, Timber Press, Portland,

Cambridge, 2004

Lise Manniche: The Ancient Egyptian Herbal, The British Museum Press, London, 1989

Martin G. J.: Ethnobotany. A Methods Manual, Earthscan, London, 2007

Minnis P. E.: Ethnobotany. A Reader, University of Oklahoma Press, U.S.A., 2000

Moerman, Daniel E.: Native American Ethnobotany, Timber Press, Portland, London, 2010

Paye, Gabriell DeBear: Cultural Uses of Plants, The New York Botanical Garden Press, Bronx, New York, 2000

Lectures

1 Ethnopharmacological data of the Ancient Times (Egypt, Mesopotamia).

Dr. Papp Nóra

2 Ethnopharmacological data of the Ancient Times (Egypt, Mesopotamia).

Dr. Papp Nóra

3 Ethnobotanical studies of the Native Indian populations of North, South and Central America (Cuba, Mexico).

Dr. Papp Nóra

4 Ethnobotanical studies of the Native Indian populations of North, South and Central America (Cuba, Mexico).

Dr. Papp Nóra

5 Ethnopharmacology of the ancient cultures of Iran, China, India, Tibet, Japan.

Dr. Papp Nóra

6 Ethnopharmacology of the ancient cultures of Iran, China, India, Tibet, Japan.

Dr. Papp Nóra

7 Ethnopharmacology of African and Mediterranean countries (Greece, Spain, Portugal, Italy).

Dr. Papp Nóra

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8 Ethnopharmacology of African and Mediterranean countries (Greece, Spain, Portugal, Italy).

Dr. Papp Nóra

9 Ethnopharmacological data from the Middle Ages: therapy and medicinal plants in monastery gardens.

Dr. Papp Nóra

10 Ethnopharmacological data from the Middle Ages: therapy and medicinal plants in monastery gardens.

Dr. Papp Nóra

11 Transylvanian ethnobotanical values.

Dr. Papp Nóra

12 Transylvanian ethnobotanical values.

Dr. Papp Nóra

13 Written test I.

Dr. Papp Nóra

14 Written test I.

Dr. Papp Nóra

15 Ancient medico-botanical and herbal books and written sources with the morphological and therapeutical description of medicinal

plants.

Dr. Papp Nóra

16 Ancient medico-botanical and herbal books and written sources with the morphological and therapeutical description of medicinal

plants.

Dr. Papp Nóra

17 Scientific activity and curriculum vitae of ethnobotanists.

Dr. Papp Nóra

18 Scientific activity and curriculum vitae of ethnobotanists.

Dr. Papp Nóra

19 Methodologies in ethnobotanical collection.

Dr. Papp Nóra

20 Methodologies in ethnobotanical collection.

Dr. Papp Nóra

21 Interactive lecture: analysis and elaboration of scientific articles published in international journals and books based on the

knowledge and view of the previous lectures.

Dr. Papp Nóra

22 Interactive lecture: analysis and elaboration of scientific articles published in international journals and books based on the

knowledge and view of the previous lectures.

Dr. Papp Nóra

23 Traditional and folk terminology in plant names.

Dr. Papp Nóra

24 Traditional and folk terminology in plant names.

Dr. Papp Nóra

25 Documentation of ethnobotanical data - case studies

Dr. Papp Nóra

26 Documentation of ethnobotanical data - case studies

Dr. Papp Nóra

27 Written test II.

Dr. Papp Nóra

28 Written test II.

Dr. Papp Nóra

Practices

Seminars

Exam topics/questions

According to the topics of the course.

Participants

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OPE-TG3-T STUDENT PROJECT RESEARCH FOR STUDENTS OF PHARMACEUTIST PROGRAMME 3

Course director: DR. GYÖRGYI HORVÁTH, associate professor

Department of Pharmacognosy [email protected]

2 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ both semesters ▪ recommended semester: 5

Number of hours/semester: 0 lectures + 24 practices + 0 seminars = total of 24 hours

Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPF-TG2-T completed

Topic

The course aims at promoting of students to make student research projects on the field of pharmaceutical sciences. Furthermore, we

wish to give individual possibilities of students to perform experiments in the different pharmaceutical institutes involved into Students’

Research Society.

Conditions for acceptance of the semester

The continuous student’s work is recommended. The continuous enrollment of consecutive courses can be stopped and continued in

further semesters.

The prerequisite of this course (TDK 3): registration of the student in the database of Students’ Research Society and the fulfillment of

the Student Project Research for Students of Pharmaceutist Programme 2 course.

Mid-term exams

- Introduction of conference abstract or conference manuscript (student is co-author) for the course supervisor at the end of 13th week of

the semester.

- Introduction of original article published in national and/or international journals (student is co-author) at the end of 13th week of the

semester.

- Participation on Students’ Research Conference.

- Among the three conditions, one of them should be made at least.

Making up for missed classes

There is no possibility.

Reading material

- Obligatory literature

- Literature developed by the Department

- Notes

- Recommended literature

ScienceDirect database

Lectures

Practices

1-24 Research.

Seminars

Exam topics/questions

Not applicable.

Participants

Dr. Horváth Györgyi (GDLTCH)

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OPE-GMK-T QUALITATIVE AND QUANTITATIVE ANALYSIS OF DRUGS FROM HUMAN TISSUE

Course director: DR. ÁGNES FARKAS, associate professor

Department of Pharmacognosy [email protected]

2 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ autumn semester ▪ recommended semester: 5

Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours

Course headcount limitations (min.-max.): 3 – 50 Prerequisites: none

Topic

The course provides knowledge about the traceability of active pharmaceutical ingredients in various biological matrices. It discusses

sampling of biological matrices, sample preparation (extraction) methods [LLE, SPE, SPEC, SPME, MEPS], and various

chromatographic techniques [TLC, GC, LC] as well.

The course intends to present the CNS effects of active pharmaceutical ingredients, as well as drugs in the official investigation. The

sampling procedures and techniques are presented, as well as their official confidence circumstances.

The appearance of drug compounds and drugs in biological matrices, and their pharmacokinetic properties are discussed, as well as

traceability of live and corpse biological matrices (blood, urine, hair, nails, saliva, or liver, kidney, brain, or cerebrospinal fluid).

After proper selection of analytical tests, the requirements set for a variety of measuring instruments will be discussed. Standard

evaluation and communication, as well as the laws and regulations in force in the analytical results complete the course topics.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Students have to prove their knowledge of the course material by presenting a selected topic in a short (10 min) talk. The topic should be

related to one of the topics of the course, and students should rely on their knowledge acquired in previous classes.

Making up for missed classes

According to the Code of Studies and Examinations

Reading material

- Obligatory literature

R.C. Baselt: Disposition of Toxic Drugs and Chemicals in Man, 6th ed., Biomedical Publications, Foster City, CA, 2002

A.C. Moffat, M.D. Osselton, B. Widdop: Clarke’s Analysis of Drugs and Poisons, Pharmaceutical Press, London, 2004.

- Literature developed by the Department

The Lecturer’s presentations (ppt files) will be available from the website of the Department of Pharmacognosy.

- Notes

- Recommended literature

R.J. Flanagan, A. Taylor, I.D. Watson, R. Whelpton: Fundamentals of Analytical Toxicology, John Wiley & Sons, Hoboken, NJ,

2007.

Lectures

1 Introduction to Toxicology. Categorization of Toxins I

Dr. Benkő András Antal

2 Introduction to Toxicology. Categorization of Toxins II

Dr. Benkő András Antal

3 Effect of Poisons on the Living Body I

Dr. Benkő András Antal

4 Effect of Poisons on the Living Body II

Dr. Benkő András Antal

5 Investigation in Forensic Laboratories. Sampling rules. I

Dr. Benkő András Antal

6 Investigation in Forensic Laboratories. Sampling rules. II

Dr. Benkő András Antal

7 Investigation of Non-standard Human Tissues I

Dr. Benkő András Antal

8 Investigation of Non-standard Human Tissues II

Dr. Benkő András Antal

9 Biological Materials Preparation. Extraction Procedures I

Dr. Benkő András Antal

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10 Biological Materials Preparation. Extraction Procedures II

Dr. Benkő András Antal

11 Forensic Toxicological Investigation of Human Samples by Chromatography I

Dr. Benkő András Antal

12 Forensic Toxicological Investigation of Human Samples by Chromatography II

Dr. Benkő András Antal

13 Criteria and Evaluation. Expert Opinion in Forensic Toxicology I

Dr. Benkő András Antal

14 Criteria and Evaluation. Expert Opinion in Forensic Toxicology II

Dr. Benkő András Antal

15 Natural Cannabinoids (marihuana, hashish, and hashish oil) I

Dr. Benkő András Antal

16 Natural Cannabinoids (marihuana, hashish, and hashish oil) II

Dr. Benkő András Antal

17 Synthetic Cannabino-mimetics (spice, pot-puri, herbal, bio-grass, K2) I

Dr. Benkő András Antal

18 Synthetic Cannabino-mimetics (spice, pot-puri, herbal, bio-grass, K2) II

Dr. Benkő András Antal

19 First Generation of Amphetamines (ecstasy, speed)

Dr. Benkő András Antal

20 Second generation of disco drugs (catinon and derivatives)

Dr. Benkő András Antal

21 Opiates (morphine, codeine, heroine) I

Dr. Benkő András Antal

22 Opiates (morphine, codeine, heroine) II

Dr. Benkő András Antal

23 Cocaine

Dr. Benkő András Antal

24 Body-pack Syndrome.

Dr. Benkő András Antal

25 Final Student ppt Presentation I

Dr. Benkő András Antal

26 Final Student ppt Presentation II

Dr. Benkő András Antal

27 Final Student ppt Presentation III

Dr. Benkő András Antal

28 Final Student ppt Presentation IV

Dr. Benkő András Antal

Practices

Seminars

Exam topics/questions

10 min ppt presentation based on an international forensic science article

Participants

Dr. Benkő András Antal (VF70AV)

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OPF-MOD-T MOLECULAR DIAGNOSTICS

Course director: DR. JUDIT ERZSÉBET PONGRÁCZ, professor

Department of Pharmaceutical Biotechnology [email protected]

1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 5

Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours

Course headcount limitations (min.-max.): 5 – 150 Prerequisites: none

The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

Structure of a molecular genetic laboratory, working areas, special devices and instrumentation. Biological information.

Conditions for acceptance of the semester

According to the Code of Studies and Examinations

Mid-term exams

Writing test

Making up for missed classes

According to the Code of Studies and Examinations

Reading material

- Obligatory literature

- Literature developed by the Department

- Notes

www.medbiotech.com

- Recommended literature

Lectures

1 Structure of a molecular genetic laboratory, working areas, special devices and instrumentation. Biological information.

Dr. Pongrácz Judit Erzsébet

2 Mutations, polymorphisms. The genetic code.

Dr. Pongrácz Judit Erzsébet

3 Mutations, polymorphisms. The genetic code.

Dr. Pongrácz Judit Erzsébet

4 Special mutation consequences.

Dr. Pongrácz Judit Erzsébet

5 Dynamic mutations.

Dr. Pongrácz Judit Erzsébet

6 Mendelian inheritance.

Dr. Pongrácz Judit Erzsébet

7 Multifactorial diseases.

Dr. Pongrácz Judit Erzsébet

8 Examples for monogenic diseases.

Dr. Pongrácz Judit Erzsébet

9 Examples for monogenic diseases.

Dr. Pongrácz Judit Erzsébet

10 Examples for monogenic diseases.

Dr. Pongrácz Judit Erzsébet

11 Pharmacogenetics.

Dr. Pongrácz Judit Erzsébet

12 Molecular testing in oncology.

Dr. Pongrácz Judit Erzsébet

13 Methodology of the molecular diagnostic procedures.

Dr. Pongrácz Judit Erzsébet

14 Methodology of the molecular diagnostic procedures.

Dr. Pongrácz Judit Erzsébet

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Practices

Seminars

Exam topics/questions

www.medbiotech.com

Participants

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OPF-MME-T MOLECULAR MEDICINE

Course director: DR. JUDIT ERZSÉBET PONGRÁCZ, professor

Department of Pharmaceutical Biotechnology [email protected]

1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 5

Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours

Course headcount limitations (min.-max.): 5 – 150 Prerequisites: none

The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

Introduction into molecular medicine

Conditions for acceptance of the semester

According to the Code of Studies and Examinations

Mid-term exams

Writing test

Making up for missed classes

None

Reading material

- Obligatory literature

- Literature developed by the Department

- Notes

www.medbiotech.com

- Recommended literature

Lectures

1 Introduction into molecular medicine

Dr. Pongrácz Judit Erzsébet

2 The genome

Dr. Pongrácz Judit Erzsébet

3 Sequencing of the genome

Dr. Pongrácz Judit Erzsébet

4 Investigation of the human genome with microarrays

Dr. Pongrácz Judit Erzsébet

5 Genes and diseases

Dr. Pongrácz Judit Erzsébet

6 Nuclear receptors

Dr. Pongrácz Judit Erzsébet

7 Personalized genetics

Dr. Pongrácz Judit Erzsébet

8 Immunodeficiencies

Dr. Pongrácz Judit Erzsébet

9 Cancers (introduction)

Dr. Pongrácz Judit Erzsébet

10 Molecular mechanisms of cancer development

Dr. Pongrácz Judit Erzsébet

11 Obesity: introduction

Dr. Pongrácz Judit Erzsébet

12 Genomics of obesity

Dr. Pongrácz Judit Erzsébet

13 Genes involved in development of obesity

Dr. Pongrácz Judit Erzsébet

14 Therapeutic approaches to obesity. Interconnected mechanisms in lipid metabolism

Dr. Pongrácz Judit Erzsébet

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Practices

Seminars

Exam topics/questions

www.medbiotech.com

Participants

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OPF-MOT-T MOLECULAR THERAPIES

Course director: DR. JUDIT ERZSÉBET PONGRÁCZ, professor

Department of Pharmaceutical Biotechnology [email protected]

1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 5

Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours

Course headcount limitations (min.-max.): 5 – 150 Prerequisites: none

The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

Gene therapy, in vivo gene therapy

Conditions for acceptance of the semester

According to the Code of Studies and Examinations

Mid-term exams

Writing test

Making up for missed classes

None

Reading material

- Obligatory literature

- Literature developed by the Department

- Notes

www.medbiotech.com

- Recommended literature

Lectures

1 Functional genomics I

Dr. Pongrácz Judit Erzsébet

2 Functional genomics II

Dr. Pongrácz Judit Erzsébet

3 Recombinant protein expression

Dr. Pongrácz Judit Erzsébet

4 Gene therapy, in vivo gene therapy

Dr. Pongrácz Judit Erzsébet

5 Ex vivo gene therapy, Therapies based on protein replacement I

Dr. Pongrácz Judit Erzsébet

6 Therapies based on protein replacement II

Dr. Pongrácz Judit Erzsébet

7 Recombinant antibodies and phage phage display technique

Dr. Pongrácz Judit Erzsébet

8 Anti-cytokine therapy (Sepsis)

Dr. Pongrácz Judit Erzsébet

9 Transgene technology and mouse models in modern biological research

Dr. Pongrácz Judit Erzsébet

10 Embryonic and adult stem cells for regenerative medicine I

Dr. Pongrácz Judit Erzsébet

11 Embryonic and adult stem cells for regenerative medicine II

Dr. Pongrácz Judit Erzsébet

12 Cell cycle and cancer therapy, p53 I

Dr. Pongrácz Judit Erzsébet

13 Cell cycle and cancer therapy, p53 II

Dr. Pongrácz Judit Erzsébet

14 Gene silencing technologies

Dr. Pongrácz Judit Erzsébet

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Practices

Seminars

Exam topics/questions

www.medbiotech.com

Participants

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OPF-HVS-T SYNTHESIS OF HETEROCYCLIC COMPOUNDS AND THEIR APPLICATION IN THERAPY

Course director: DR. TAMÁS KÁLAI, professor

Department of Pharmaceutical Chemistry [email protected]

2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 5

Number of hours/semester: 0 lectures + 0 practices + 28 seminars = total of 28 hours

Course headcount limitations (min.-max.): 1 – 12 Prerequisites: OPA-S1E-T completed

Topic

Heterocyclic chemistry is an important subdivision of organic chemistry, as 70% of all medicines are heterocyclic compound or contains

a heterocyclic moiety. This course will give an introduction to, and the summary of, the most important principles and ideas of

heterocyclic chemistry. This course partially re-calls the knowledge of Organic chemisty 1 and Organic chemistry 2 course, discusses

those details which were not reflected on, because of time shortage and supports to evaluate the pharmacological chemistry subject.

-Electronic structure of heterocycles

-Nomenclature of heterocyclic compounds

-Main synthetic routes to heterocyclic compounds, Saturated heterocycles, occurence of heterocycles

-Three and four membered heterocycles (synthesis, reactions, occurence)

-The pyrrole and indole (synthesis, reactions, occurence)

-Furan, thiophene and their benzo derivatives.

-Five membered heterocycles with two or more heteroatoms: imidazole, oxazole, thiazole

-Pyrazole, isoxazole, isothiazole

-I. st test, Six-membered heterocycles with one oxygen heteroatom (piranes, chromones, flavones and coumarins)

-Six membered heterocycles with one nitrogen atom (pyridine, quinoline, isoquinoline)

-Six membered heterocycles with two or more heteroatoms (purine, diazines, triazines etc.)

-Seven membered heterocyclic chemistry

-Heterocycles in supramolecular chemitry

-Heterocyclic compounds in organic snthesis

-II nd test, short presntation on a paper on heterocyclic chemistry

-Evaluation

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

The students write two tests, at the middle of the semester and at the end of the semester. Every student have a chance to make a

presentation based on a heterocyclic chemistry paper for an extra grade.

Making up for missed classes

Personal communication. The english program student might visit the paralell hungarian course to catch up the main reaction equations.

Reading material

- Obligatory literature

Li, J. J. Hetrocyclic chemistry in Drug Discovery, Wiley

- Literature developed by the Department

Slides will be given to students as a ppt or pdf files.

- Notes

Joule, J. J.; Mills, K. Heterocyclic chemistry at a Glance. (Wiley)

- Recommended literature

Li, J. J. Top 10 drugs Oxfors University Press

Lectures

Practices

Seminars

1 Electronic structure of heterocycles, nomenclature of heterocycles

2 Occurence of heterocyclic compounds

3 Synthesis of heterocycles

4 Common reaction types in heterocyclic chemistry

5 Tautomerism in heterocyclic chemistry

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6 Saturated heterocycles

7 Three and four membered heterocycles, beta lactams

8 Three and four-membered heterocycles and beta lactams

9 Synthesis of pyrroles and porfirine ring containing compounds

10 Synthesis of indoles, main reactions of indoles.

11 Furans and thiophenes

12 Thiophenes and benzothiophenes

13 1,2-azoles, their synthesis, reactions and their occurence in drugs

14 1,3-azoles, their synthesis, reactions, occurence in drugs

15 1st test (generral feature of heterocyclic compounds (3-, 4-, 5-membered heterocycles)

16 Six membered heterocycles containing oxygen heteroatom

17 Pyridines (synthesis, reactions, occurence in drugs and biomolecules)

18 Quinolines, isoquinolines (synthesis, reactions, occurence in drugs)

19 Synthesis of pyrimidines and their occurence in medicines

20 Synthesis and reactions of 1,2- and 1,4-diazines

21 Synthesis and reactions of triazines and purines

22 Heterocycles of life and death

23 Seven membered heterocycles their occurence, synthesis, applications in therapy

24 IInd test, short presentations on papers on heterocyclic chemistry, evaluation

25 Heterocycles in supramolecular chemistry

26 Heterocycles in organic synthesis

27 2nd test (6- and 7-membered heterocycles)

28 Short presentations, evaluations

Exam topics/questions

-Electronic structure of heterocycles

-Nomenclature of heterocyclic compounds

-Main synthetic routes to heterocyclic compounds

-Saturated heterocycles

-Three and four membered heterocycles (synthesis, reactions, occurence)

-The pyrrole and indole (synthesis, reactions, occurence)

-Furan, thiophene and their benzo derivatives.

-Five membered heterocycles with two or more heteroatoms

-Six-membered heterocycles with one oxygen heteroatom (piranes, chromones, flavones and coumarins)

-Six membered heterocycles with one nitrogen atom (pyridine, quinoline, isoquinoline)

-Six membered heterocycles with two or more heteroatoms (purine, diazines etc.)

-Seven membered heterocyclic chemistry

- Heterocycles in supramolecular chemitry

-Heterocyclic compounds in organic snthesis

Participants

Dr. Kálai Tamás (BDF5M9)

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OPF-GLK-T BIOINORGANIC CHEMISTRY FOR PHARMACY STUDENTS

Course director: DR. IMRE HUBER, associate professor

Department of Pharmaceutical Chemistry [email protected]

1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 5

Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours

Course headcount limitations (min.-max.): 5 – 15

Prerequisites: OPA-T2E-T completed + OPA-S2E-T completed + OPO-GE2-T completed

Topic

We will provide an overview in this block about bioinorganic topics of chemistry, regarding the role of the different elements in medicinal

and pharmaceutical chemistry. Our aim is to offer a concise knowledge also about bioinorganic relations on medical contrast agents like

X-ray, tomographic, MR and ultrasound contrast agents. The use of radionuclids in diagnostical methods will be discussed too.

Conditions for acceptance of the semester

Maximum of 15 % absence allowed

Mid-term exams

Students will have to write a written test at the end of the semester.

Making up for missed classes

In case of absences the students must follow up with self-education!

Reading material

- Obligatory literature

- Literature developed by the Department

Lecture notes provided by the lecturer.

- Notes

- Recommended literature

Lectures

1 Introduction, The biological importance of non-metals and metals.

Dr. Huber Imre

2 An overview of the elements.

Dr. Huber Imre

3 Rtg-contrast agents.

Dr. Huber Imre

4 Watersoluble nephrothrop Rtg-contrast agents with high osmolality.

Dr. Huber Imre

5 Watersoluble nephrothrop Rtg-contrast agents with low osmolality.

Dr. Huber Imre

6 Watersoluble hepatothrop Rtg-contrast agents.

Dr. Huber Imre

7 Water-insoluble Rtg-contrast agents.

Dr. Huber Imre

8 Contrast agents for MRI.

Dr. Huber Imre

9 Contrast agents for CT.

Dr. Huber Imre

10 Contrast agents for ultrasound.

Dr. Huber Imre

11 Radioactive diagnostics (radionuclids).

Dr. Huber Imre

12 Platinum comlexes in medicin. Chelation therapy.

Dr. Huber Imre

13 Bisphosphonates in medicin.

Dr. Huber Imre

14 Geometry of complexes. Closing written test.

Dr. Huber Imre

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Practices

Seminars

Exam topics/questions

These are listed in the lecture notebook written by the lecturer. These notes are about the different questions of this field with the

corresponding answers, parallely.

Participants

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OPF-TS1-T CALCULATIONS IN PHARMACEUTICAL TECHNOLOGY 1

Course director: DR. SZILÁRD PÁL, assistant professor

Institute of Pharmaceutical Technology and Biopharmacy [email protected]

1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 5

Number of hours/semester: 0 lectures + 0 practices + 12 seminars = total of 12 hours

Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPG-C1E-T parallel + OPG-GI1-T completed

Topic

Aim of the course is to deepen the knowledge of calculations needed for Pharmaceutical Technology 1 practice (dose checking,

prescription reading and understanding) by solving and practicing several examples together with the course leader.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Participation on the seminars - accepted work reports - accepted written assessments Students have to write an end-semester assessment

from the lectures at acceptance level of 60%.

Making up for missed classes

Students must fulfil requirements determined by the Code of Studies and Examinations. Student has to make up the missed lectures and

do work reports.

Reading material

- Obligatory literature

- Literature developed by the Department

Seminar notes.

- Notes

- Recommended literature

European Pharmacopoeia

Formulae Normales VII. (FoNo VII.)

James Swarbrick: Encyclopedia of Pharmaceutical Technology, Informa Healthcare, New York, London

Gilbert S. Banker, Christopher T. Rhodes: Modern Pharmaceutics, Marcel Dekker Inc., New York- Basel

Chris Langley, Dawn Belcher: Pharmaceutical Compounding and Dispensing, Pharmaceutical Press

Attila Dévay: The Theory and Practice of Pharmaceutical Technology, electronic book, PTE-Pécs

Attila Dévay: Investigation of Pharmaceutical Preparations, electronic book, PTE-Pécs

Lectures

Practices

Seminars

1 Introduction to pharmaceutical technological calculations, praciticing and understanding expressions found on prescriptions

2 Concept of concentration

3 Basic calculations of clear solutions (mixing rule)

4 Calculations of ethanol dilution

5 Fundamentals of dose checking (understanding the prescription, syrup factor, elderly factor)

6 Dose checking in solutions 1.

7 Dose checking in solutions 2.

8 Dose checking in peroral drops 1.

9 Dose checking in peroral drops 2.

10 Calculation of isotonicity 1.

11 Calculation of isotonicity 2.

12 Test

Exam topics/questions

Students can get the test topics in the institute or download the from website of the institute.

Participants

Ámanné Dr. Takácsi-Nagy Anna (SEGAOR), Dr. Kása Péter (ISWPRM), Dr. Pál Szilárd (FYF5E9)

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OPF-GKG-T GAS CHROMATOGRAPHY

Course director: DR. VIKTÓRIA POÓR, assistant professor

Institute of Bioanalysis [email protected]

1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 5

Number of hours/semester: 8 lectures + 4 practices + 0 seminars = total of 12 hours

Course headcount limitations (min.-max.): 4 – 15 Prerequisites: OPA-M1E-T completed

Topic

Key Topics

-practical theory about Gas Chromatography

-how to select and use the carrier gas

-various injection techniques and when to use each

-how to select a GC column

-the operation and selection of an appropriate GC detector

-how to write measuring methods

-how to undertake data analysis

-sampling techniques for GC

-strategies for method development

-introduction to GC & MS advanced techniques

-applications (pharmaceutical application)

Conditions for acceptance of the semester

Maximum of 15 % absence allowed

Mid-term exams

1 test during the semester

1 oral presentation (based on research articles on the field of pharmaceutical apllication)

Making up for missed classes

There is no possibility for retake

Reading material

- Obligatory literature

Modern Analytical Cheymistry,David Harvey

- Literature developed by the Department

www.aok.pte.hu/bioanalitika

- Notes

- Recommended literature

Lectures

1 practical theory about Gas Chromatography

Dr. Poór Viktória

2 how to select and use the carrier gas

-various injection techniques and when to use each

Dr. Poór Viktória

3 how to select a GC column

-the operation and selection of an appropriate GC detector

Dr. Poór Viktória

4 strategies for method development

Dr. Poór Viktória

5 introduction to GC & MS advanced techniques

Dr. Poór Viktória

6 introduction to GC & MS advanced techniques

Dr. Poór Viktória

7 how to write measuring methods

Dr. Poór Viktória

8 how to undertake data analysis

Dr. Poór Viktória

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Practices

1 GC practice 1

2 GC practice 2

3 GC-MS 1.

4 GC-MS 2.

Seminars

Exam topics/questions

1 test during the semester

1 oral presentation (based on research articles on the field of pharmaceutical apllication)

Participants

Dr. Poór Viktória (MJELTX)

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OPF-EGZ-T EXOTIC MEDICINAL PLANTS

Course director: DR. KAMILLA ÁCS, assistant professor

Department of Pharmacognosy [email protected]

2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 5

Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours

Course headcount limitations (min.-max.): 5 – 25 Prerequisites: OPO-G2E-T completed

Topic

The course includes 28 lectures. The aim of the course is to present the most frequently used exotic plants in the medical therapy. The

course gives a general overview about the botanical character, active ingredients, and drug part of the plants. Application forms and

safety instructions are also highlighted during the lectures. Herbs and drugs will presented according to their areas of application.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Oral presentation about a medicinal value of a selected plant. Fulfillment of the final test (minimum 60%).

Making up for missed classes

Downloading of lectures in Neptun.

Reading material

- Obligatory literature

- Literature developed by the Department

- Notes

- Recommended literature

Bremness L. (1988): The Complete Book of Herbs: A Practical Guide to Growing and Using Herbs.

Ratsch C., Hofmann A.(2007): The Encyclopedia of Psychoactive Plants: Ethnopharmacology and Its Applications.

Kane C.W. (2007): Medicinal Plants of the Western Mountain States

Bett J. (2015): Chinese Medicinal Plants: How To Grow Them, How To Use Them: Growing and Using Herbs And Plants For

Natural Remedies And Healing.

Lectures

1 Herbs of the gastrointestinal tract I.

Dr. Ács Kamilla

2 Herbs of the gastrointestinal tract II.

Dr. Ács Kamilla

3 Herbs of the gastrointestinal tract III.

Dr. Ács Kamilla

4 Herbs of the gastrointestinal tract IV.

Dr. Ács Kamilla

5 Aromatic plants and products containing essential oils I.

Dr. Ács Kamilla

6 Aromatic plants and products containing essential oils II.

Dr. Ács Kamilla

7 Aromatic plants and products containing essential oils III.

Dr. Ács Kamilla

8 Aromatic plants and products containing essential oils IV.

Dr. Ács Kamilla

9 Herbs and products containing fatty oils I.

Dr. Ács Kamilla

10 Herbs and products containing fatty oils II.

Dr. Ács Kamilla

11 Plants for external use, dermatology and cosmetics I.

Dr. Ács Kamilla

12 Plants for external use, dermatology and cosmetics II.

Dr. Ács Kamilla

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13 Plants which affect the central nervous system I.

Dr. Ács Kamilla

14 Plants which affect the central nervous system II.

Dr. Ács Kamilla

15 Plants for cardiovascular disorders I.

Dr. Ács Kamilla

16 Plants for cardiovascular disorders II.

Dr. Ács Kamilla

17 Plants for well-being I.

Dr. Ács Kamilla

18 Plants for well-being II.

Dr. Ács Kamilla

19 Psychoactive and hallucinogenic plants I.

Dr. Ács Kamilla

20 Psychoactive and hallucinogenic plants II.

Dr. Ács Kamilla

21 Plants with immunostimulant effect I.

Dr. Ács Kamilla

22 Plants with immunostimulant effect II.

Dr. Ács Kamilla

23 Plants for tropical, and contagious diseases I.

Dr. Ács Kamilla

24 Plants for tropical, and contagious diseases II.

Dr. Ács Kamilla

25 Presentations of students I.

Dr. Ács Kamilla

26 Presentations of students II.

Dr. Ács Kamilla

27 Exam

Dr. Ács Kamilla

28 Exam

Dr. Ács Kamilla

Practices

Seminars

Exam topics/questions

It is similar to the topics of lectures.

Participants

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ATT5-T PHYSICAL EDUCATION 5

Course director: ISTVÁN KARSAI, senior lecturer

UP MS Sports Facilities [email protected]

0 credit ▪ signature ▪ Optional subject ▪ both semesters ▪ recommended semester: 5-6-7-8-9-10

Number of hours/semester: 0 lectures + 28 practices + 0 seminars = total of 28 hours

Course headcount limitations (min.-max.): 2 – 50 Prerequisites: ATT4-T completed

The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

This subject provides theoretical and practical information for the students to maintain and improve their physical condition and helps to

deepen the knowledge in the field of healthy lifestyle.

Theoretical and practical knowledge during different types of exercises e.g. how to improve endurance, muscle force, motor skills and

how to prevent the body from injuries.

Conditions for acceptance of the semester

Active participation at least 20 practical lessons provided by the Institute of Human Movement Sciences or regular participation of the

trainings of the Medikus Sport Club or PEAC.

Mid-term exams

Making up for missed classes

We provide opportunities to attend extra lessons in the first week of the exam period in that case the requirements are not fulfilled till the

end of the teaching weeks with agreement of the PE Teacher.

Reading material

- Obligatory literature

- Literature developed by the Department

Not available.

- Notes

- Recommended literature

Lectures

Practices

1-28 For the list of actual courses please turn to the end of the 1st year’s obligatory subjects booklet

Seminars

Exam topics/questions

Participants

Farkas György (CL1MIY), Lipcsik Zoltán (EGE1AE), Németh Attila Miklós (EXB7TD), Téczely Tamás (P0OP8M)

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OPF-VGG-T COLLECTING AND CONSERVATION OF WILD NATIVE MEDICINAL PLANTS

Course director: DR. DRAGICA PURGER, assistant professor

Department of Pharmacognosy [email protected]

2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 5

Number of hours/semester: 24 lectures + 4 practices + 0 seminars = total of 28 hours

Course headcount limitations (min.-max.): 5 – 20 Prerequisites: OPO-G2E-T completed + OPO-G2G-T completed

Topic

Collecting and conservation of wild native medicinal plants is an elective course that will help in obtaining wider knowledge related to

medicinal plants. The topic covers wild medicinal plants native to Hungary, their morphological description, their occurrence and

significance. It describes in detail the methodology and possibilities for collecting wild medicinal plants in nature, and discusses strategies

for the conservation of rare and endangered herb species. The course includes a half-day field trip to Pécs-Nagyarpád, where the main

focus is on the recognition of native wild medicinal plants in nature. The students can broaden their knowledge related to wild medicinal

plants and their application in pharmacist practice.

Conditions for acceptance of the semester

Maximum of 15 % absence allowed

Mid-term exams

Written test

Making up for missed classes

Upon individual agreement. Field practices cannot be missed or made up for.

Reading material

- Obligatory literature

- Literature developed by the Department

- Notes

- Recommended literature

Shi Lin Chen et al. 2016: Conservation and sustainable use of medicinal plants: problems, progress, and prospects. Chin Med 11:37

(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967523/pdf/13020_2016_Article_108.pdf)

Danna J. Leaman: Sustainable wild collection of medicinal and aromatic plants. Development of an international standard

https://library.wur.nl/frontis/medicinal_aromatic_plants/07_leaman.pdf

Medicinal Plant Specialist Group Species Survival Commission IUCN 2007: International Standard for Sustainable Wild Collection

of Medicinal and Aromatic Plants (ISSC-MAP) Version 1.0- The World Conservation Union

https://www.bfn.de/fileadmin/MDB/documents/service/skript195.pdf

Lectures

1 Importance of wild medicinal plants

Dr. Purger Dragica

2 Collection of wild medicinal plants in Hungary; historical overview

Dr. Purger Dragica

3 Methods of the collection of wild medicinal plants

Dr. Purger Dragica

4 Methods of the collection of wild medicinal plants

Dr. Purger Dragica

5 National and regional databases of wild medicinal plants

Dr. Purger Dragica

6 Collection Calendar

Dr. Purger Dragica

7 Primary processing of collected medicinal plants

Dr. Purger Dragica

8 Primary processing of collected medicinal plants

Dr. Purger Dragica

9 General quality requirements

Dr. Purger Dragica

10 General quality requirements

Dr. Purger Dragica

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11 International conventions and rules

Dr. Purger Dragica

12 International conventions and rules

Dr. Purger Dragica

13 Estimating the population size of medicinal plants

Dr. Purger Dragica

14 Estimating the population size of medicinal plants

Dr. Purger Dragica

15 Endangered, protected and strictly protected native medicinal plants

Dr. Purger Dragica

16 Endangered, protected and strictly protected native medicinal plants

Dr. Purger Dragica

17 Monitoring populations of threatened species

Dr. Purger Dragica

18 Monitoring populations of threatened species

Dr. Purger Dragica

19 Strategies for conservation of endangered medicinal plants

Dr. Purger Dragica

20 Strategies for conservation of endangered medicinal plants

Dr. Purger Dragica

21 The role of botanical gardens in ex situ preserving of medicinal plants

Dr. Purger Dragica

22 The role of botanical gardens in ex situ preserving of medicinal plants

Dr. Purger Dragica

23 Exam: Written test

Dr. Purger Dragica

24 Exam: Written test

Dr. Purger Dragica

Practices

1 General information on plant parts collected

2 The most important wild native medicinal plants in Hungary, their habitats and distribution

3 Collecting wild medicinal plants in the field

4 Collecting wild medicinal plants in the field

Seminars

Exam topics/questions

1. Importance of wild medicinal plants

2. Collection of wild medicinal plants

3. Methods of the collection of wild medicinal plants

4. The most important wild native medicinal plants in Hungary

5. Collecting wild medicinal plants in the field

6. Collection Calendar

7. Primary processing of collected medicinal plants

8. General quality requirements

9. International conventions and rules

10. Estimating the population size of medicinal plants

11. Endangered, protected and strictly protected native medicinal plants

12. Monitoring populations of threatened species

13. Strategies for conservation of endangered medicinal plants

14. The role of botanical gardens in ex situ preserving of medicinal plants

Participants

Dr. Purger Dragica (FCCWBF)

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OPF-GMT-T DRUG METABOLISM AND DRUG TOXICITY

Course director: DR. ATTILA ALMÁSI, assistant professor

Department of Pharmaceutical Chemistry [email protected]

1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 5

Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours

Course headcount limitations (min.-max.): 3 – 50 Prerequisites: OPO-G1B-T completed

Topic

On the seminaries of this facultative course the molecular background and the influenceability of the side and toxic effects of different

drugs are aimed, during the drug absorption, drug transformation and drug elimination.

During the course, the metabolic activation and transformation of the environmental carcinogens are to be discussed.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

In the end of the semester the students write an end-semester test. The test is evaluated in percentage and the final grade is to be established

based on this result. The result of the test should be above 60%.

Making up for missed classes

The replacement of the missed test is required.

Reading material

- Obligatory literature

- Literature developed by the Department

Slides of the lectures.

- Notes

- Recommended literature

Lectures

1 Introduction. The toxicological aspects of drug metabolism.

Dr. Almási Attila

2 Characteristics of xenobiotics in the body

Dr. Almási Attila

3 Metabolic transformation I. Phase I. or functionalisation reactions 1 (CYP enzymes).

Dr. Almási Attila

4 Metabolic transformations II. Phase I. or functionalisation reactions 2 (FAD enzymes and non microsomal transformations).

Dr. Almási Attila

5 Metabolic transformations III. Phase II. or conjugation reactions 1 ( glucuronic acid conjugation, sulphate conjugation).

Dr. Almási Attila

6 Metabolic transformations IV. Phase II. or conjugation reactions 2 ( amino acid conjugation, acetylation, methylation, gluthatione

conjugation).

Dr. Almási Attila

7 Phase III. transformations (transporters), general molecular mechanism of drug toxicity.

Dr. Almási Attila

8 Biotransformation and the toxic effects of the paracetamol. Factors influence the toxicity of the paracetamol.

Dr. Almási Attila

9 Toxicity of the non-steroid antiinflammatory drugs (NSAIDs). Hepatotoxic effect of the diclofenac.

Dr. Almási Attila

10 Toxicity of the troglitazone. Sulfonamide hypersensitivity.

Dr. Almási Attila

11 Chemical carcinogenesis I., Definition, cell division, environmental carcinogens, chemical carcinogenesis.

Dr. Almási Attila

12 Chemical carcinogenesis II., Structure and metabolic activation of environmental carcinogens.

Dr. Almási Attila

13 Metabolic differences between species, genetic polymorphism.

Dr. Almási Attila

14 Changes in drug metabolism during pregnancy and at aged people.

Dr. Almási Attila

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Practices

Seminars

Exam topics/questions

Based on the announced thesis list.

Participants

Dr. Almási Attila (KJ5MBZ)

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OPE-STK-T BASICS OF STEREOCHEMISTRY

Course director: DR. IMRE HUBER, associate professor

Department of Pharmaceutical Chemistry [email protected]

1 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ spring semester ▪ recommended semester: 6

Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours

Course headcount limitations (min.-max.): 5 – 15

Prerequisites: OPA-S2E-T completed + OPG-R1E-T completed + OPO-GE2-T completed

Topic

In the frame of this topic we will provide an overview about fundamentals of stereochemical definitions and processes. The students will

receive the most important knowledge about stereochemistry, with what they can understand the different binding types of drugs to their

place of biological action.

Conditions for acceptance of the semester

Maximum of 15 % absence allowed

Mid-term exams

Students will have to write a written test at the end of the semester.

Making up for missed classes

In case of absences the students must follow up with self-education!

Reading material

- Obligatory literature

- Literature developed by the Department

Lecture notes provided by the lecturer.

- Notes

Lecture notes provided by the lecturer.

- Recommended literature

K.-H. Hellwich, C. D. Siebert: Stereochemistry workbook, 191 problems and solutions, Springer, 2006.

Lectures

1 Introduction, confoguration, conformation definitions.

Dr. Huber Imre

2 Chirality, asymmetry.

Dr. Huber Imre

3 Asymmetric syntheses

Dr. Huber Imre

4 Fischer projection, CIP system.

Dr. Huber Imre

5 Diastereomers, enantiomers.

Dr. Huber Imre

6 Epimers, eutomers, distomers.

Dr. Huber Imre

7 Homochirality, inversion, meso-isomers.

Dr. Huber Imre

8 Newman projection.

Dr. Huber Imre

9 Optical purity.

Dr. Huber Imre

10 Prochirality, prostereoisomerism.

Dr. Huber Imre

11 Racemate, racemisation.

Dr. Huber Imre

12 Retention in stereochemistry.

Dr. Huber Imre

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13 Stereoselectivity, stereospecificity.

Dr. Huber Imre

14 Summary, written test.

Dr. Huber Imre

Practices

Seminars

Exam topics/questions

These are listed in the lecture notebook written by the lecturer. These notes are about the different questions of this field with the

corresponding answers, parallely.

Participants

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OPF-SNA-T CARBON NANOSTRUCTURES

Course director: DR. BEÁTA LEMLI, assistant professor

Department of Organic and Pharmacological Chemistry [email protected]

2 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ spring semester ▪ recommended semester: 6

Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours

Course headcount limitations (min.-max.): 5 – 20 Prerequisites: OPG-R1E-T completed

Topic

Carbon is an indispensable element of life, thanks to the ability to form different chemical bonds with most elements of the periodic

table, enabling the creation of different and complex life forms. The discovery of the organic carbon compounds has been started in the

19th century, and now they are the part of our lives. Nowadays the previously discovered allotropes of carbon - fullerenes, carbon

nanotubes, graphenes, graphene nanoribbons - are in the focus, however, their real wide application still seems to be a big challenge and

needs further investigations. During this curse, students will be introduced to the promising pharmaceutical chemistry, medical and

biological applications of these materials and to the latest results of related research.

Conditions for acceptance of the semester

Maximum of 15 % absence allowed

Mid-term exams

One written exam during the semester, the acceptance level is 60%. One oral presentation by students.

Making up for missed classes

There is no possibility to make up for a missed lecture and practice

Reading material

- Obligatory literature

Physical Biochemistry: Applications to Biochemistry and Molecular Biology (Life Sciences/Biochemistry) by David M. Freifelder,

2nd Edition, ISBN-13: 978-0716714446, ISBN-10: 0716714442

- Literature developed by the Department

The slides of the lectures are electronically available.

- Notes

- Recommended literature

Physical Biochemistry: Applications to Biochemistry and Molecular Biology (Life Sciences/Biochemistry) by David M. Freifelder,

2nd Edition, ISBN-13: 978-0716714446, ISBN-10: 0716714442

Lectures

1 Introduction of the course requirements. Fullerenes, carbon nanostructure, graphene: their discovery, historical review

Dr. Lemli Beáta

2 Preparation, synthesis, cleaning, general properties

Dr. Lemli Beáta

3 Covalent and non-covalent functionalization of carbon nanomaterials

Dr. Lemli Beáta

4 Covalent and non-covalent functionalization of carbon nanomaterials

Dr. Lemli Beáta

5 Cellular uptake mechanism of carbon nanotubes

Dr. Lemli Beáta

6 Cellular uptake mechanism of carbon nanotubes

Dr. Lemli Beáta

7 Carbon nanotube biodistribution

Dr. Lemli Beáta

8 Carbon nanotube biodistribution

Dr. Lemli Beáta

9 Application of carbon nanocapsules in drug delivery

Dr. Lemli Beáta

10 Application of carbon nanocapsules in drug delivery

Dr. Lemli Beáta

11 Carbon nanotubes applied for in vitro, in vivo and in silico drug delivery

Dr. Lemli Beáta

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12 Carbon nanotubes applied for in vitro, in vivo and in silico drug delivery

Dr. Lemli Beáta

13 Carbon nanostructures and DNA

Dr. Lemli Beáta

14 Carbon nanostructures and DNA

Dr. Lemli Beáta

15 Novel strategies for cancer diagnosis and treatment

Dr. Lemli Beáta

16 Novel strategies for cancer diagnosis and treatment

Dr. Lemli Beáta

17 The toxicity of carbon nanomaterials

Dr. Lemli Beáta

18 The toxicity of carbon nanomaterials

Dr. Lemli Beáta

19 Outlook: about the nanomedicines and drug delivery nanosystems

Dr. Lemli Beáta

20 Student’s lecture.

Dr. Lemli Beáta

21 Written test.

Dr. Lemli Beáta

22 Written test.

Dr. Lemli Beáta

23 Summary and conclusions

Dr. Lemli Beáta

24 Summary and conclusions

Dr. Lemli Beáta

Practices

Seminars

Exam topics/questions

The topics of the written test are similar to the topics of the lectures.

Participants

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OPE-VFM-T BUSINESS DEVELOPMENT AND MANAGEMENT

Course director: DR. RITA BOGNÁR, research associate professor

Department of Biochemistry and Medical Chemistry [email protected]

2 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ spring semester ▪ recommended semester: 6

Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours

Course headcount limitations (min.-max.): 1 – 30 Prerequisites: none

Topic

The main objective of the course is to develop the business orientation skills of the students, while deepening their knowledge in business

models, business plans, innovative business strategies, time-, product-, process- and human resource management. Participants will have

the capability how to develop healthcare businesses in international environment and how to plan better their time.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

TVSZ szerint

Making up for missed classes

TVSZ szerint

Reading material

- Obligatory literature

- Literature developed by the Department

Neptun

- Notes

- Recommended literature

1. Baum Neil, Thomas Raju : The Basics of Business of Medicine, 2015

2. Helen Ewing: Healthcare Finance: An Introduction to Accounting and Financial Management, 5th edition, 2013

Lectures

1 Global healthcare

Dr. Bognár Rita

2 Different healthcare systems

Dr. Bognár Rita

3 Regional healthcare

Dr. Bognár Rita

4 Different types of business organisations

Dr. Bognár Rita

5 Innovation, Innovative businesses

Dr. Bognár Rita

6 Business Model Generation

Dr. Bognár Rita

7 Business plan

Dr. Bognár Rita

8 Business plan development

Dr. Bognár Rita

9 Intercultural business communication

Dr. Bognár Rita

10 Basics of Marketing in healthcare business

Dr. Bognár Rita

11 Production

Dr. Bognár Rita

12 Product and process management

Dr. Bognár Rita

13 Quality management

Dr. Bognár Rita

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14 Time planning, Time management

Dr. Bognár Rita

15 Human resource management

Dr. Bognár Rita

16 Team building, Team work

Dr. Bognár Rita

17 Strategic management

Dr. Bognár Rita

18 Risk management

Dr. Bognár Rita

19 Healthcare finance

Dr. Bognár Rita

20 Introduction to accounting and financial management

Dr. Bognár Rita

21 Sustainable healthcare

Dr. Bognár Rita

22 Presenation methods and techniques

Dr. Bognár Rita

23 Administration, Documentation, Reports

Dr. Bognár Rita

24 Summary for written test

Dr. Bognár Rita

Practices

Seminars

Exam topics/questions

Neptun

Participants

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OPE-TG4-T STUDENT PROJECT RESEARCH FOR STUDENTS OF PHARMACEUTIST PROGRAMME 4

Course director: DR. GYÖRGYI HORVÁTH, associate professor

Department of Pharmacognosy [email protected]

2 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ both semesters ▪ recommended semester: 6

Number of hours/semester: 0 lectures + 24 practices + 0 seminars = total of 24 hours

Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPE-TG3-T completed

Topic

The course aims at promoting of students to make student research projects on the field of pharmaceutical sciences. Furthermore, we

wish to give individual possibilities of students to perform experiments in the different pharmaceutical institutes involved into Students’

Research Society.

Conditions for acceptance of the semester

The continuous student’s work is recommended. The continuous enrollment of consecutive courses can be stopped and continued in

further semesters.

The prerequisite of this course (TDK 4): registration of the student in the database of Students’ Research Society and the fulfillment of

the Student Project Research for Students of Pharmaceutist Programme 3 course.

Mid-term exams

- Introduction of conference abstract or conference manuscript (student is co-author) for the course supervisor at the end of 13th week of

the semester.

- Introduction of an article published in a national and/or international journal (student is co-author). It must be sent to the course

supervisor at the end of 13th week of the semester.

- Oral presentation at the Students’ Research Conference.

- Dean’s thesis

- Among the four conditions, one of them should be made at least.

Making up for missed classes

There is no possibility.

Reading material

- Obligatory literature

- Literature developed by the Department

- Notes

- Recommended literature

ScienceDirect database

Lectures

Practices

1-24 Research.

Seminars

Exam topics/questions

Not applicable.

Participants

Dr. Horváth Györgyi (GDLTCH)

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OPE-GFK-T PHYSICO-CHEMICAL BASES OF DRUG ACTION

Course director: DR. ZSUZSANNA ROZMER, assistant professor

Department of Pharmaceutical Chemistry [email protected]

2 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ spring semester ▪ recommended semester: 6

Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours

Course headcount limitations (min.-max.): 3 – 15 Prerequisites: none

Topic

The main objective of this course is to expand the knowledge in phyisico-chemical characterization of drug molecules and drug targets

for better understanding the drug action.

Conditions for acceptance of the semester

Maximum of 15 % absence allowed

Mid-term exams

Written test.

Making up for missed classes

None.

Reading material

- Obligatory literature

- Literature developed by the Department

Zsuzsanna Rozmer, Pál Perjési: The physico-chemeical bases of drug actions. PTE, 2015.

- Notes

- Recommended literature

Lectures

1 Molecular bases of biological actions. Structural characteristics of drug targets.

Dr. Rozmer Zsuzsanna

2 Molecular bases of biological actions. Structural characteristics of drug targets.

Dr. Rozmer Zsuzsanna

3 Receptors as drug targets.

Dr. Rozmer Zsuzsanna

4 Receptors as drug targets.

Dr. Rozmer Zsuzsanna

5 Enzymes as drug targets.

Dr. Rozmer Zsuzsanna

6 Enzymes as drug targets.

Dr. Rozmer Zsuzsanna

7 Transporters and ion channels as drug targets.

Dr. Rozmer Zsuzsanna

8 Transporters and ion channels as drug targets.

Dr. Rozmer Zsuzsanna

9 Nucleic acids as drug targets.

Dr. Rozmer Zsuzsanna

10 Nucleic acids as drug targets.

Dr. Rozmer Zsuzsanna

11 Physicochemical properties of drug-drug target interactions. Intermolecular bonding.

Dr. Rozmer Zsuzsanna

12 Physicochemical properties of drug-drug target interactions. Intermolecular bonding.

Dr. Rozmer Zsuzsanna

13 Physicochemical properties of drug-drug target interactions. Affinity. Efficiency and selectivity.

Dr. Rozmer Zsuzsanna

14 Physicochemical properties of drug-drug target interactions. Affinity. Efficiency and selectivity.

Dr. Rozmer Zsuzsanna

15 Physicochemical properties of drug-drug target interactions. Stucture, stereochemistry.

Dr. Rozmer Zsuzsanna

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16 Physicochemical properties of drug-drug target interactions. Stucture, stereochemistry.

Dr. Rozmer Zsuzsanna

17 Physicochemical characteristics of drugs. Solubility.

Dr. Rozmer Zsuzsanna

18 Physicochemical characteristics of drugs. Solubility.

Dr. Rozmer Zsuzsanna

19 Physicochemical characteristics of drugs. Acid-base properties. Relevance and determination of the pKa value.

Dr. Rozmer Zsuzsanna

20 Physicochemical characteristics of drugs. Acid-base properties. Relevance and determination of the pKa value.

Dr. Rozmer Zsuzsanna

21 Physicochemical characteristics of drugs. Lipophilicity and partition coefficient. Determination of partition coefficients.

Dr. Rozmer Zsuzsanna

22 Physicochemical characteristics of drugs. Lipophilicity and partition coefficient. Determination of partition coefficients.

Dr. Rozmer Zsuzsanna

23 Physicochemical characteristics of drugs. Permeability. Experimental methods to determine permeability.

Dr. Rozmer Zsuzsanna

24 Physicochemical characteristics of drugs. Permeability. Experimental methods to determine permeability.

Dr. Rozmer Zsuzsanna

25 In silico ADME modelling. In vitro and in vivo tests.

Dr. Rozmer Zsuzsanna

26 In silico ADME modelling. In vitro and in vivo tests.

Dr. Rozmer Zsuzsanna

27 Physicochemical characteristics of drugs. Metabolic stability.

Dr. Rozmer Zsuzsanna

28 Physicochemical characteristics of drugs. Metabolic stability.

Dr. Rozmer Zsuzsanna

Practices

Seminars

Exam topics/questions

Topics of the written tests are set by the course director.

Participants

Dr. Rozmer Zsuzsanna (IIDYH7)

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OPE-FAO-T APPLIED HEALTH ECONOMICS

Course director: DR. LAJOS BOTZ, professor

Department of Pharmaceutics and University Pharmacy [email protected]

2 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ spring semester ▪ recommended semester: 6

Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours

Course headcount limitations (min.-max.): 5 – 25 Prerequisites: OGG-GI1-T completed

Topic

Health economics applies economic thinking to the analysis of health and health care. This course provides students with an

understanding of the health economics principles and tools to analyse and address the challenges of limited resources faced by the health

sector.

By attending this course, students will

- learn about the key principles and methods of health economic evaluations and models

- know how to interpret the results of health economic evaluations

- gain insight into the perspective of decision makers

- better understand the crucial policy debates relating to health care.

The module is primarily aimed at medical, pharmacy and economic students who would like to improve their understanding of health

economics and research methods and at other students who are interested in the field.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Retake opportunity is possible following personal discussion.

Making up for missed classes

Retake opportunity is possible following personal discussion.

Reading material

- Obligatory literature

- Literature developed by the Department

All presentations can be downloaded from Neptun Meet Street.

- Notes

- Recommended literature

Lectures

1 Introduction to health economics 1.

Dr. Zemplényi Antal Tamás

2 Introduction to health economics 2.

Dr. Zemplényi Antal Tamás

3 Making decisions in healthcare 1.

Dr. Zemplényi Antal Tamás

4 Making decisions in healthcare 2.

Dr. Zemplényi Antal Tamás

5 Economic evaluation in healthcare (CEA, CUA, CBA) 1.

Dr. Zemplényi Antal Tamás

6 Economic evaluation in healthcare (CEA, CUA, CBA) 2.

Dr. Zemplényi Antal Tamás

7 Life tables and extrapolation 1.

Dr. Zemplényi Antal Tamás

8 Life tables and extrapolation 2.

Dr. Zemplényi Antal Tamás

9 Survival analysis 1.

Dr. Zemplényi Antal Tamás

10 Survival analysis 2.

Dr. Zemplényi Antal Tamás

11 Analysing health outcomes (QALY) 1.

Dr. Zemplényi Antal Tamás

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12 Analysing health outcomes (QALY) 2.

Dr. Zemplényi Antal Tamás

13 Measuring and valuing costs in healthcare 1.

Dr. Zemplényi Antal Tamás

14 Measuring and valuing costs in healthcare 2.

Dr. Zemplényi Antal Tamás

15 Health technology assessment - case study 1.

Dr. Zemplényi Antal Tamás

16 Health technology assessment - case study 2.

Dr. Zemplényi Antal Tamás

17 Decision analytic modelling: decision trees (practical exercise) 1.

Dr. Zemplényi Antal Tamás

18 Decision analytic modelling: decision trees (practical exercise) 2.

Dr. Zemplényi Antal Tamás

19 Decision analytic modelling: Markov models (practical exercise) 1.

Dr. Zemplényi Antal Tamás

20 Decision analytic modelling: Markov models (practical exercise) 2.

Dr. Zemplényi Antal Tamás

21 Interpreting cost-effectiveness results 1.

Dr. Zemplényi Antal Tamás

22 Interpreting cost-effectiveness results 2.

Dr. Zemplényi Antal Tamás

23 Market access of new pharmaceuticals - case study 1.

Dr. Zemplényi Antal Tamás

24 Market access of new pharmaceuticals - case study 2.

Dr. Zemplényi Antal Tamás

Practices

Seminars

Exam topics/questions

Based on the topics of the lectures.

Participants

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OPE-ASZ-T THE ANTIMICROBIAL DRUGS AND THEIR CLINICAL USE

Course director: DR. BÉLA KOCSIS, associate professor

Department of Medical Microbiology and Immunology [email protected]

2 credit ▪ midsemester grade ▪ Elective subject for the Medical-biological module ▪ spring semester ▪ recommended semester: 6

Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours

Course headcount limitations (min.-max.): 5 – 100 Prerequisites: none

The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

The aim of these lectures is to give a reliable and detailed knowledge about the antimicrobial drugs and their clinical use; to give ideas

how to choose the proper drug for the prophylaxis and therapy of infectious diseases

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

In the first 2 weeks of the exam period we give three times possibilities to write tests

Making up for missed classes

None

Reading material

- Obligatory literature

Jawetz et al.: Medical Microbiology

- Literature developed by the Department

- Notes

- Recommended literature

Lectures

1 Introduction, historical data, basic definitions

Dr. Kocsis Béla

2 Characterisation of antimicrobial drugs, chemical structure, their targets

Dr. Kocsis Béla

3 Characterisation of antimicrobial drugs, sensitivity and resistance

Dr. Kocsis Béla

4 Pharmacokinetics and pharmacodynamics of anti-infective drugs

Dr. Kocsis Béla

5 The antibiotic prophylaxis.

Dr. Kocsis Béla

6 The empiric antimicrobial therapy

Dr. Kocsis Béla

7 The antimicrobial therapy based on microbiologic result

Dr. Kocsis Béla

8 The choice of best antimicrobial drug

Dr. Kocsis Béla

9 The reasons of an unsuccessful antimicrobial therapy

Dr. Kocsis Béla

10 The antimicrobial drugs in details. The inhibitors of the cell wall biosynthesis Beta-lactams Penicillins

Dr. Kocsis Béla

11 Cephalosporins, carbapenems, monobactams, glicopeptides

Dr. Kocsis Béla

12 The inhibitors of the protein biosynthesis Aminoglicosides

Dr. Kocsis Béla

13 Tetracyclines Chloramphenicol Macrolides

Dr. Kocsis Béla

14 The inhibitors of the nucleic acid biosynthesis Rifampins Sulfonamides

Dr. Kocsis Béla

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15 Kinolons Fluorokinolons

Dr. Kocsis Béla

16 The antimycotic drugs

Dr. Kocsis Béla

17 The antiviral drugs HIV - AIDS

Dr. Kocsis Béla

18 The antiparasitic therapy. The chemoprophylaxis of malaria

Dr. Kocsis Béla

19 The antimicrobial therapy of respiratory and urinary tract infections

Dr. Kocsis Béla

20 Cardiovascular and wound infections, sepsis

Dr. Kocsis Béla

21 Central nervous system, abdominal and enteric infections

Dr. Kocsis Béla

22 Antimicrobial therapy of patients under immunosuppression, pregnancy....

Dr. Kocsis Béla

23 The pharmacological aspects of antimicrobial therapy

Dr. Kocsis Béla

24 The future of antimicrobial therapy

Dr. Kocsis Béla

Practices

Seminars

Exam topics/questions

None

Participants

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OPE-KPR-T CHEMOPREVENTION

Course director: DR. TÍMEA VARJAS, assistant professor

Department of Public Health Medicine [email protected]

1 credit ▪ midsemester grade ▪ Elective subject for the Medical-biological module ▪ spring semester ▪ recommended semester: 6

Number of hours/semester: 12 lectures + 0 practices + 0 seminars = total of 12 hours

Course headcount limitations (min.-max.): 1 – 20 Prerequisites: OPO-G2B-T completed

The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

Chemoprevention is the administration of natural or (semi)synthetic agents to prevent, inhibit, or delay the progression of chronic

diseases. The focus is on cancer chemoprevention.

The way from a potent agent to a chemopreventive strategy will also be discussed.

Involving (chemo)preventive interventions in every-day practice could spare valuable life years.

Conditions for acceptance of the semester

Absences should not exceed 15% of lectures and practicals (2x45 min). Otherwise signature of grade book is denied.

Examination: test

Mid-term exams

Examination: test

Making up for missed classes

based on individual consideration

Reading material

- Obligatory literature

- Literature developed by the Department

PPT-presentations (Neptun)

- Notes

- Recommended literature

Lectures

1 Introduction - Chemoprevention as a preventive strategy

Dr. Szabó István

2 Introduction - Chemoprevention as a preventive strategy

Dr. Szabó István

3 Finding evidence

Dr. Szabó István

4 Finding evidence

Dr. Szabó István

5 Interventing chronic diseases

Dr. Szabó István

6 Interventing chronic diseases

Dr. Szabó István

7 Chemopreventive strategies - antioxidants

Dr. Szabó István

8 Actualities of antioxidants

Dr. Szabó István

9 Natural chemopreventive agents

Dr. Szabó István

10 Natural chemopreventive agents

Dr. Szabó István

11 Chemopreventive dietary factors

Dr. Szabó István

12 Chemopreventive dietary factors

Dr. Szabó István

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Practices

Seminars

Exam topics/questions

Neptun

Participants

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OPF-TS2-T CALCULATIONS IN PHARMACEUTICAL TECHNOLOGY 2

Course director: DR. SZILÁRD PÁL, assistant professor

Institute of Pharmaceutical Technology and Biopharmacy [email protected]

1 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 6

Number of hours/semester: 0 lectures + 0 practices + 12 seminars = total of 12 hours

Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPG-C2E-T parallel + OPG-C1E-T completed

Topic

Aim of the course is to deepen the knowledge of calculations needed for Pharmaceutical Technology 2 practice (dose checking,

prescription reading and understanding) by solving and practicing several examples together with the course leader.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Participation on the seminars - accepted work reports - accepted written assessments Students have to write an end-semester assessment

from the lectures at acceptance level of 60%.

Making up for missed classes

Students must fulfil requirements determined by the Code of Studies and Examinations. Student has to make up the missed lectures and

do work reports.

Reading material

- Obligatory literature

- Literature developed by the Department

Seminar notes.

- Notes

- Recommended literature

European Pharmacopoeia

Formulae Normales VII. (FoNo VII.)

James Swarbrick: Encyclopedia of Pharmaceutical Technology, Informa Healthcare, New York, London

Gilbert S. Banker, Christopher T. Rhodes: Modern Pharmaceutics, Marcel Dekker Inc., New York- Basel

Chris Langley, Dawn Belcher: Pharmaceutical Compounding and Dispensing, Pharmaceutical Press

Attila Dévay: The Theory and Practice of Pharmaceutical Technology, electronic book, PTE-Pécs

Attila Dévay: Investigation of Pharmaceutical Preparations, electronic book, PTE-Pécs

Lectures

Practices

Seminars

1 Introduction to calculations of disperse systems

2 Calculations related to HLB value

3 Dose checking in emulsions

4 Dose checking in suspensions

5 Calculations related to semi-solid dosage forms

6 Introduction to calculations related to suppositories (calibration value and displacement factor)

7 Calculations of divided form of prescribing suppositories

8 Calculations of dispensed form of prescribing suppositories

9 Dose checking of suppositories 1.

10 Dose checking of suppositories 2.

11 Dose checking of divided and undivided powders

12 Test

Exam topics/questions

Students can get the test topics in the institute or download the from website of the institute.

Participants

Ámanné Dr. Takácsi-Nagy Anna (SEGAOR), Dr. Kása Péter (ISWPRM), Dr. Pál Szilárd (FYF5E9)

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OPF-DTS-T THE ROLE OF DRUG TRANSPORTERS

Course director: DR. LUCA JÁROMI, assistant professor

Department of Pharmaceutical Biotechnology [email protected]

2 credit ▪ midsemester grade ▪ Optional subject ▪ both semesters ▪ recommended semester: 6

Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours

Course headcount limitations (min.-max.): 5 – 15 Prerequisites: OPG-R1E-T completed

Topic

Understanding the clinical importance, role and molecular procedures of interindividual variability in drug response is a critical area of

drug development and clinical pharmacotherapy.The genetic polymorphisms in drug-metabolizing enzymes, receptors, transporters and

other drug targets may have a crucial role in the background of this phenomenon, that can lead to the interindividual differences in

molecular ways, efficacy, as well as toxicity as a response to numerous clinical treatment. Cancer is the leading cause of mortality and

morbidity worldwide. The greatest obstacle of the successful treatment is the development of multidrug resistance (MDR) against

chemotherapy. During the past two decades, the act of carrier-mediated transport in defining the pharamcokinetics of drugs has become

progressively evident with the discovery of genetic polymorphisms that influence expression, localization, and/or function of a given

drug transporter. The aim of the course is to present the drug transporters and their genetic and pharmacogenetic background, to explain

their role in drug metabolism, especially focusing on different drug transporter families and on interactions of protein - drug - transporters.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Félév végén vizsga, vizsgaidőszakban pótvizsga lehetőségek

Making up for missed classes

Nincs, mert csak előadásokból áll a kurzus.

Reading material

- Obligatory literature

- Literature developed by the Department

PPT-bemutatók az előadások során.

- Notes

- Recommended literature

1.) Yuichi Sugiyama - Bente Steffansen: Transporters in Drug Development Discovery, Optimization,

Clinical Study and Regulation, ISSN 2210-7371 ISSN 2210-738X (electronic), ISBN 978-1-4614-8228-4 ISBN 978-1-4614-8229-1

(eBook), DOI 10.1007/978-1-4614-8229-1, Springer New York Heidelberg Dordrecht London

Library of Congress Control Number: 2013947789

2.) Toshihisa Ishikawa, Richard B. Kim: Pharmacogenomics of Human Drug Transporters, ISBN 978-0-470-92794-6

3.) Russ. B. Altman, David Flockhart, David B. Goldstein: Pharmacogenetics and Pharmacogenomics, ISBN 978-0-521-88537-9

Lectures

1 Introduction to world of drug transporters

Dr. Járomi Luca

2 General characteristics of drug transporters

Dr. Járomi Luca

3 Terms definition of drug transporters

Dr. Járomi Luca

4 Genetic role of drug transporters

Dr. Járomi Luca

5 Pharmacogenetic characteristics of drug transporters

Dr. Járomi Luca

6 Basics in phamacokinetics: definition of absorption, distribution, metabolism, and excretion (ADME)

Dr. Járomi Luca

7 Explanation of absorption, distribution, metabolism, and excretion (ADME)

Dr. Járomi Luca

8 Membrane transporters in ADME I.

Dr. Járomi Luca

9 Membrane transporters in ADME II.

Dr. Járomi Luca

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10 ADME pharmacogenomics in drug development I.

Dr. Járomi Luca

11 ADME pharmacogenomics in drug development II.

Dr. Járomi Luca

12 The role of transporters in drug development: regulatory science perspectives from the FDA

Dr. Járomi Luca

13 Industrial evaluation of drug transporters in ADME

Dr. Járomi Luca

14 The pharmacogenomics of membrane transporters I.

Dr. Járomi Luca

15 The pharmacogenomics of membrane transporters II.

Dr. Járomi Luca

16 Nucleoside transporters family

Dr. Járomi Luca

17 General characteristics of ABC-transporter family

Dr. Járomi Luca

18 Most relevant ones: ABC-transporters

Dr. Járomi Luca

19 P-glycoprotein (MDR1/ABCB1)

Dr. Járomi Luca

20 ABCG2

Dr. Járomi Luca

21 Cancer: exsorptive transporters (ABC) expressed on transformed cells

Dr. Járomi Luca

22 Proton-coupled nutrient transporters affect ADME properties

Dr. Járomi Luca

23 In vitro characterization of interactions with drug transporting proteins

Dr. Járomi Luca

24 In vivo characterization of interactions on transporters

Dr. Járomi Luca

25 Indication specific transporter studies

Dr. Járomi Luca

26 Future perspectives

Dr. Járomi Luca

27 Conclusions and outlook, summary

Dr. Járomi Luca

28 Exam

Dr. Járomi Luca

Practices

Seminars

Exam topics/questions

Introduction to world of drug transporters

General characteristics of drug transporters

Terms definition of drug transporters

Genetic role of drug transporters

Pharmacogenetic characteristics of drug transporters

Basics in phamacokinetics: definition of absorption, distribution, metabolism, and excretion (ADME)

Explanation of absorption, distribution, metabolism, and excretion (ADME)

Membrane transporters in ADME I.

Membrane transporters in ADME II.

ADME pharmacogenomics in drug development I.

ADME pharmacogenomics in drug development II.

The role of transporters in drug development: regulatory science perspectives from the FDA

Industrial evaluation of drug transporters in ADME

The pharmacogenomics of membrane transporters I.

The pharmacogenomics of membrane transporters II.

Nucleoside transporters family

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General characteristics of ABC-transporter family

Most relevant ones: ABC-transporters

P-glycoprotein (MDR1/ABCB1)

ABCG2

Cancer: exsorptive transporters (ABC) expressed on transformed cells

Proton-coupled nutrient transporters affect ADME properties

In vitro characterization of interactions with drug transporting proteins

In vivo characterization of interactions on transporters

Indication specific transporter studies

Future perspectives

Participants

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OPF-EXT-T EXTRACTION AND CHROMATOGRAPHIC TECHNIQUES IN MEDICINAL PLANT ANALYSIS

Course director: DR. TÍMEA BENCSIK, assistant professor

Department of Pharmacognosy [email protected]

2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 6

Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours

Course headcount limitations (min.-max.): 5 – 20 Prerequisites: OPA-M1E-T completed

The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

With the increasing demand for herbal medicinal products, nutraceuticals, and natural products for health care all over the world,

medicinal plant extract manufacturers and essential oil producers have started using the most appropriate extraction and chromatographic

technologies in order to produce and standardize extracts and essential oils of defined quality. The aim of this course is to introduce the

most important extraction methods and chromatographic techniques used in the research of medicinal plants. Students should be able to

apply the acquired knowledge in their medical or pharmaceutical practice.

Task: To introduce state-of-the-art extraction techniques (maceration, infusion, digestion, decoction, percolation, Soxhlet, ultrasound

extraction, supercritical fluid extraction, water and steam distillation, enfleurage, expression) and chromatographic analyses (column

chromatography, thin layer chromatography, high pressure liquid chromatography) of medicinal plants and their role in the production

of herbal medicines. Some applications, relating to different classes of substances, are presented to demonstrate the versatility of various

chromatographic techniques.

Requirements: students have to know the most frequent extraction and analytical techniques used in medicinal and aromatic plant

research.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

One written exam during the semester, the acceptance level is 60%. One oral presentation by students.

Making up for missed classes

There is no possibility to make up for a missed lecture and practice.

Reading material

- Obligatory literature

- Literature developed by the Department

PowerPoint presentations prepared by lecturers.

- Notes

- Recommended literature

1. Handa S.S., Khanuja S.P.S., Longo G., Rakesh D.D.: Extraction Technologies for Medicinal and Aromatic Plants, International

Centre for Science and High Technology, Trieste, 2008

2. Reich E., Schibli A.: High-Performance Thin-Layer Chromatography for the Analysis of Medicinal Plants, Thieme, UK, 2007

3. Colegate S.M.: Bioactive Natural Products Detection Isolation and Structural Determination, CRC Press, 2008

4. Niessen W.M.A.: Liquid Chromatography - Mass Spectrometry, CRC Press, 2006

5. Nyiredy, Sz.: Planar Chromatography, Springer, Budapest, 2001.

6. Harris, DC.: Quantitative Chemical Analysis, WH. Freeman and Co., 7th edition, New York, 2007,

7. Schiedt K., Liaaen-Jensen S.: Isolation and Analysis, in Carotenoids Vol. 1A: Isolation and Analysis, Eds.: Britton G., Liaaen-

Jensen S., Pfander H., Birkhäuser Verlag, Basel, 1995.

Lectures

1 Introduction of the course requirements. An Overview of Extraction Techniques for Medicinal and Aromatic Plants.

Dr. Bencsik Tímea

1 Chromatographic seminar: TLC.

Dr. Benkő András Antal

2 Introduction of state-of-the-art extraction techniques: maceration, infusion, digestion, decoction, percolation, Soxhlet, ultrasound

extraction, supercritical fluid extraction, water and steam distillation, enfleurage, expression.

Dr. Bencsik Tímea

2 Chromatographic seminar: HPLC.

Dr. Bencsik Tímea

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3 Introduction to Analytical Separations.

Dr. Benkő András Antal

4 Techniques for the Purposes of Botanical Research.

Dr. Benkő András Antal

5 Planar Chromatography: TLC.

Dr. Benkő András Antal

6 Role of Different Procedures and Test Systems in the Knowledge of Herbal Substances.

Dr. Benkő András Antal

7 Column Chromatography Systems: GC.

Dr. Benkő András Antal

8 Column Chromatography Systems: HPLC.

Dr. Benkő András Antal

9 Detectors Used in Different Separation Techniques and their Role in Qualitative and Quantitative Analysis.

Dr. Benkő András Antal

10 Classification of Detectors Based on their Sensitivity and Selectivity.

Dr. Benkő András Antal

11 Role of thin layer chromatography (TLC) in detecting microbiological processes: TLC-Bioautography.

Dr. Horváth Györgyi

12 Antimicrobial activity of essential oils using TLC-Bioautography.

Dr. Horváth Györgyi

13 Isolation and identification of carotenoids from medicinal plants.

Dr. Molnár Péter

14 Role of column liquid chromatography (CLC) in carotenoid research.

Dr. Molnár Péter

15 Examination of honeys, sugars, polyphenols.

Dr. Farkas Ágnes

16 Examination of honeys, sugars, polyphenols.

Dr. Farkas Ágnes

17 Identification of specific metabolites in herbal products. Adulterated dietary supplements.

Dr. Bencsik Tímea

18 Identification of specific metabolites in herbal products with TLC.

Dr. Bencsik Tímea

19 Isolation and Identification of flavonoids in medicinal plants.

Dr. Papp Nóra

20 Isolation and Identification of flavonoids in medicinal plants.

Dr. Papp Nóra

21 Quality of herbal products; our experiences in the Department of Pharmacognosy.

Dr. Bencsik Tímea

22 Quality of herbal products; our experiences in the Department of Pharmacognosy.

Dr. Bencsik Tímea

23 Student’s lecture.

Dr. Bencsik Tímea

24 Student’s lecture.

Dr. Bencsik Tímea

25 Written test.

Dr. Bencsik Tímea

26 Written test.

Dr. Bencsik Tímea

Practices

Seminars

Exam topics/questions

The topics of the 1 written test are similar to the topics of the lectures.

Participants

Dr. Bencsik Tímea (MIVXFC), Dr. Benkő András Antal (VF70AV)

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OPF-KNH-T PSYCHOACTIVE PLANTS

Course director: DR. KAMILLA ÁCS, assistant professor

Department of Pharmacognosy [email protected]

2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 6

Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours

Course headcount limitations (min.-max.): 5 – 25 Prerequisites: OPO-G2E-T completed

Topic

The course includes 28 lectures. The aim of the course is to present the most commonly used psychoactive plants and hallucionogens

around the world. The course gives a general overview about the botanical character and medicinal value of the most frequent plants and

fungi. In addition legal regulation, international guidelines for their control and the problem of addiction are also discussed.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Fulfillment of the final test (minimum 60%).

Making up for missed classes

Downloading of lectures in Neptun.

Reading material

- Obligatory literature

- Literature developed by the Department

- Notes

- Recommended literature

Ratsch C., Hofmann A.(2007): The Encyclopedia of Psychoactive Plants: Ethnopharmacology and Its Applications.

McKenna D. (2018): Ethnopharmacologic Search for Psychoactive Drugs (Vol. 1 & 2): 50 Years of Research.

Schultes R.E. (2001): Plants of the Gods: Their Sacred, Healing, and Hallucinogenic Powers.

Willis C.(2015): Hallucinogens: The Truth About Hallucinogenic Plants.

Meuninck J. (2014): Basic Illustrated Poisonous and Psychoactive Plants.

Lectures

1 Attitude of psychoactive drugs in Hungary and Europe.

Dr. Ács Kamilla

2 Classification of psychoactive drugs: psychedelics, dissociatives and deliriants. Drug or medication?

Dr. Ács Kamilla

3 Opium and opiates around the world I.: Middle East, Western-, Middle- and South Asia

Dr. Ács Kamilla

4 Opium and opiates around the world II.: Southeast Asia, Europe, America

Dr. Ács Kamilla

5 Poppy seed (Papaver somniferum): legal use

Dr. Ács Kamilla

6 Poppy seed (Papaver somniferum): illegal use

Dr. Ács Kamilla

7 History of international audit of psychoactive drugs

Dr. Molnár Béla

8 International guidelines for the control of psychoactive substances

Dr. Molnár Béla

9 Synthetic opioids

Dr. Benkő András Antal

10 Detection of synthetic and plant originated hallucinogens. Analytics of psychoactive agents.

Dr. Benkő András Antal

11 Hallucinogenic plants I.: Solanaceae species

Dr. Ács Kamilla

12 Hallucinogenic plants II.: Ergot

Dr. Ács Kamilla

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13 Hallucinogenic plants III.: Plants from Asia

Dr. Ács Kamilla

14 Hallucinogenic plants IV.: Plants from South-America

Dr. Ács Kamilla

15 Hallucinogenic fungi

Dr. Ács Kamilla

16 Medicinal use of psychoactive plants I.: Erythroxylum coca

Dr. Ács Kamilla

17 Medicinal use of psychoactive plants II.: Catha edulis I.

Dr. Ács Kamilla

18 Medicinal use of psychoactive plants II.: Catha edulis II.

Dr. Ács Kamilla

19 Medicinal use of psychoactive plants III.: Ephedraceae I.

Dr. Ács Kamilla

20 Medicinal use of psychoactive plants III.: Ephedraceae II.

Dr. Ács Kamilla

21 Medicinal use of psychoactive plants IV: Cannabis sativa indica I.

Dr. Ács Kamilla

22 Medicinal use of psychoactive plants IV: Cannabis sativa indica II.

Dr. Ács Kamilla

23 Legalization of psychoactive agents I.

Dr. Ács Kamilla

24 Illegal drugs in criminal investigations.

Dr. Ács Kamilla

25 Drug abuse and addiction I.

Dr. Ács Kamilla

26 Drug abuse and addiction II.

Dr. Ács Kamilla

27 Exam

Dr. Ács Kamilla

28 Exam

Dr. Ács Kamilla

Practices

Seminars

Exam topics/questions

Topics include the lectures of the semester.

Participants

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OPF-NSG-T PLANT PRODUCTS IN THE PHARMACEUTICAL PRACTICE

Course director: DR. GYÖRGYI HORVÁTH, associate professor

Department of Pharmacognosy [email protected]

2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 6

Number of hours/semester: 20 lectures + 8 practices + 0 seminars = total of 28 hours

Course headcount limitations (min.-max.): 5 – 15

Prerequisites: OPO-G1E-T completed + OPO-G2E-T completed + OPG-O1E-T completed

Topic

Students will be familiar with the results of the latest studies on medicinal plants used in the prevention and treatment of diseases, and

the availability of authorized preparations and their use in modern medicine and health care, with their pharmacobotanical and

pharmacognosic knowledge. They should be able to make herbal preparations based on their knowledge.

Task: To present the active ingredient, medicinal use of medicinal herbs and preparations used in healing, to present the latest results of

phytotherapy research. Preparing tea blends and externally usable preparations in the practice sessions.

Requirement: Students should be able to apply their acquired knowledge to the highest possible level in their profession.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

During the semester, writing of one test at an acceptable level (min. 60%) is mandatory. In case of failed result, one possibility to repeat

is possible. Taking one student lecture is mandatory.

Making up for missed classes

No replacement is possible.

Reading material

- Obligatory literature

- Literature developed by the Department

- Notes

- Recommended literature

1. Aronson, JK.: Meyler’s Side Effects of Herbal Medicines, Elsevier, Oxford 2009

2. ESCOP Monographs, 2nd edition, Thieme, United Kingdom 2003

Lectures

1 Introduction. Plants on the market and their role in today’s medicine and pharmacy.

Dr. Horváth Györgyi

2 Availability of medicinal plant products on the Internet: dangers, challenges.

Dr. Horváth Györgyi

3 Herbs and products acting on the central nervous system.

Dr. Horváth Györgyi

4 Herbs and products acting on the central nervous system.

Dr. Horváth Györgyi

5 Herbs and products acting on heart and vascular system.

Dr. Horváth Györgyi

6 Herbs and products acting on heart and vascular system.

Dr. Horváth Györgyi

7 Herbs and products acting on respiratory tract.

Dr. Horváth Györgyi

8 Herbs and products acting on respiratory system.

Dr. Horváth Györgyi

9 Herbs and products acting on gastrointestinal tract.

Dr. Horváth Györgyi

10 Herbs and products acting on gastrointestinal tract.

Dr. Horváth Györgyi

11 Herbs and products acting on urinary tract.

Dr. Horváth Györgyi

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12 Herbs and products acting on urinary tract.

Dr. Horváth Györgyi

13 Herbal remedies for gynecological complaints.

Dr. Horváth Györgyi

14 Adaptogens.

Dr. Horváth Györgyi

15 Herbal remedies for dermatological diseases.

Dr. Horváth Györgyi

16 Herbal remedies for dermatological diseases.

Dr. Horváth Györgyi

17 Herbs and remedies for treating pain.

Dr. Horváth Györgyi

18 Herbs and products for treating pain.

Dr. Horváth Györgyi

19 Enhancing the body’s resistance (plant immunomodulators).

Dr. Horváth Györgyi

20 Students’s lecture. Written test.

Dr. Horváth Györgyi

Practices

1 Location of herbal remedies in today’s pharmaceuticals I: Preparation of herbal product.

2 Location of herbal remedies in today’s pharmaceuticals I: Preparation of herbal product.

3 Location of herbal remedies in today’s pharmaceuticals II: Evaluation of herbal product.

4 Location of herbal remedies in today’s pharmaceuticals II: Evaluation of herbal product.

5 Praparation of herbal tea.

6 Macroscopic and organoleptic examination of herbal tea preparation.

7 Preparation of product containing essential oils.

8 Checking the quality of herbal substances by chromatography: TLC.

Seminars

Exam topics/questions

The topics of the written test is the same with the lectures.

Participants

Dr. Horváth Györgyi (GDLTCH)

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OPF-PNT-T PHARMACEUTICAL NANOTECHNOLOGY

Course director: DR. ALEKSANDAR SECENJI, senior research fellow

Institute of Pharmaceutical Technology and Biopharmacy [email protected]

2 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 6

Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours

Course headcount limitations (min.-max.): 5 – 50 Prerequisites: OPG-C1E-T completed

Topic

Nanotechnology is a multidisciplinary discipline, which is the approach of the production of materials, structures, and systems, in which

the material is handled and produced in nanometers i.e. in a billionth of a meter. Pharmaceutical nanotechnology is the application of

nanotechnology in the pharmaceutical industry in life and health sciences and is base for the development of nanostructured modern drug

delivery systems for therapeutic purposes as well as advanced diagnostic biosensors dealing with early detection of diseases

The aim of the course is to provide a comprehensive picture of the application of nanotechnology in drug development and

pharmaceuticals. A brief introduction to the history, role, and impact of nanotechnology on state-of-the-art technologies. The properties

of specific physicochemical properties of nanomaterials can be explained by the well-known thermodynamic principles. Because of the

small size, the surface and the quantum effects play a prominent role, the theoretical basis of which is presented. Hereinafter, the

classification of nanoscale medicines and their detailed presentation will be presented.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

1 written test

Making up for missed classes

not needed

Reading material

- Obligatory literature

- Literature developed by the Department

- Notes

- Recommended literature

1. Nanotechnology in Drug Delivery, Melgardt M. de Villiers, Pornanong Aramwit, Glen S. Kwon, Springer, DOI: 10.1007/978-

0-387-77667-5

2. Pharmaceutical Nanotechnology: Fundamentals and Practical Applications, Costas Demetzos, ADIS, DOI 10.1007/978-981-

10-0791-0

3. Pharmaceutical Nanotechnology: Innovation and Production, Jean Cornier, Andrew Owen, Arno Kwade, and Marcel Van de

Voorde, WILEY-VCH, Print ISBN: 978-3-527-34054-5, ePDF ISBN: 978-3-527-80067-4

Lectures

1 Introduction to Nanotechnology

Dr. Secenji Aleksandar

2 Introduction to Nanotechnology

Dr. Secenji Aleksandar

3 Theoretical basics of nanotechnology

Dr. Secenji Aleksandar

4 Theoretical basics of nanotechnology

Dr. Secenji Aleksandar

5 Drug nanocarriers classification

Dr. Secenji Aleksandar

6 Drug nanocarriers classification

Dr. Secenji Aleksandar

7 Inorganic nanostructures

Dr. Secenji Aleksandar

8 Inorganic nanostructures

Dr. Secenji Aleksandar

9 Organic nanostructures

Dr. Secenji Aleksandar

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10 Organic nanostructures

Dr. Secenji Aleksandar

11 Pharmaceutical nanocrystals

Dr. Secenji Aleksandar

12 Pharmaceutical nanocrystals

Dr. Secenji Aleksandar

13 Matrix Systems

Dr. Secenji Aleksandar

14 Matrix Systems

Dr. Secenji Aleksandar

15 Porous systems

Dr. Secenji Aleksandar

16 Porous systems

Dr. Secenji Aleksandar

17 Binding, filling, trapping and releasing the drug from nanostructures

Dr. Secenji Aleksandar

18 Binding, filling, trapping and releasing the drug from nanostructures

Dr. Secenji Aleksandar

19 Hydrophobic drugs

Dr. Secenji Aleksandar

20 Hydrophobic drug

Dr. Secenji Aleksandar

21 Hydrophilic drugs

Dr. Secenji Aleksandar

22 Hydrophilic drugs

Dr. Secenji Aleksandar

23 Makromolecular drug carriers

Dr. Secenji Aleksandar

24 Makromolecular drug carriers

Dr. Secenji Aleksandar

25 Vesicular drug delivery systems

Dr. Secenji Aleksandar

26 Vesicular drug delivery systems

Dr. Secenji Aleksandar

27 Nano Emulsions, Pickering Emulsions

Dr. Secenji Aleksandar

28 Nano Emulsions Pickering Emulsions

Dr. Secenji Aleksandar

Practices

Seminars

Exam topics/questions

1. Introduction to Nanotechnology

2. Theoretical basics of nanotechnology

3. Drug nanocarriers classification

4. Inorganic nanostructures

5. Organic nanostructures

6. Pharmaceutical nanocrystals

7. Matrix Systems

8. Porous systems

9. Binding, filling, trapping and releasing the drug from nanostructures

10. Hydrophobic drug

11. Hydrophilic drugs

12. Makromolecular drug carriers

13. Vesicular drug delivery systems

14. Nano Emulsions Pickering Emulsions

Participants

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OPE-FMA-T DATA ANALYSIS 1

Course director: DR. LÁSZLÓ PÓTÓ, associate professor

Institute of Bioanalysis [email protected]

1 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ autumn semester ▪ recommended semester: 7

Number of hours/semester: 6 lectures + 6 practices + 0 seminars = total of 12 hours

Course headcount limitations (min.-max.): 1 – 12 Prerequisites: none

The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

The goal of this course is to help students to prepare for thesis writing or making their own student research project. It covers mainly two

fields of that: read and interpret scientific papers and prepare an own study plan. Shortly to say: How to prepare for your own study

project.

Block One: The medical papers are likely the most important source to improve your present knowledge as a student and as an

MD. Most of these ‘original papers’ are based on carefully planned data collection and evaluation applying a wide array of statistical

methods. It is essential to be familiar with this methodology so to understand these papers. But you may learn these steps and methods

from the papers since all are based on the rules of designing scientific research projects. From a paper you may extract the principles as

well as you can follow immediately the realization. It is an excellent way to learn the methodology. You may even learn from the errors.

Block Two: Apply all these for your own research: make a study plan. It should include your study goal the extent and way of

your data collection the preliminary data processing the way of data analysis and the way of conclusion making.

Based on this outline you will prepare your own study design on your own student”s research work or on your thesis job. If you have no

such project at the moment you may construct an own “;sample study plan” that can be a working model for your future thesis work.

You will have all help to find your own project and complete the plan in the practice if you need. All of your personal design elements

will be discussed and improved by a class discussion.

The practical realization of your study will be supported by the Data analysis 2 course.

Conditions for acceptance of the semester

Maximum 1 lesson absence.

Mid-term exams

Prepare and submit your own study plan step-by-step and present sortly weekly to the group - based on your active participation.

Making up for missed classes

One extra class

Reading material

- Obligatory literature

1-3 medical papers brought by each student (from library, from your department or from the tutor of your thesis).

- Literature developed by the Department

Other supporting materials supplied by the tutor of the classes.

- Notes

- Recommended literature

Any statistical books on study design and data analysis.

Lectures

1 Introduction. Find a paper to process. Find your own study.

Dr. Pótó László

2 The goal of your study - based on a demo paper

Dr. Pótó László

3 The main- and ‘sub-’hypotheses of the study.

Dr. Pótó László

4 Finding your sample frame - based on your hypotheses.

Dr. Pótó László

5 The research design and the methods of the data collection. How many data should be collected?

Dr. Pótó László

6 Creating the plan of the data analysis. The complete study plan.

Dr. Pótó László

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Practices

1 Introduction. Overview of some sample papers.

Dr. Pótó László

2 The goal of your study - processing a few papers brought and presented by students.

Dr. Pótó László

3 Setting the study hypotheses. Further analysis of the papers.

Dr. Pótó László

4 Which data should you collect and how to do that.

Dr. Pótó László

5 Finalize the plan of your data collection. Make a plan of the data processing.

Dr. Pótó László

6 Create, present and discuss of your study plan.

Dr. Pótó László

Seminars

Exam topics/questions

Preparation of the study plan

Participants

Dr. Pótó László (FIO4UU)

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OPE-FM2-T DATA ANALYSIS 2

Course director: DR. LÁSZLÓ PÓTÓ, associate professor

Institute of Bioanalysis [email protected]

1 credit ▪ midsemester grade ▪ Elective subject for the Basic module ▪ autumn semester ▪ recommended semester: 7

Number of hours/semester: 6 lectures + 6 practices + 0 seminars = total of 12 hours

Course headcount limitations (min.-max.): 1 – 12 Prerequisites: OPE-FMA-T parallel

The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

The goal of this course is to help students to prepare for thesis writing or making their own student research project. It covers two fields

of that job: the practice of data collection and prepare data for the analysis as well as the performing the analysis based on the preliminary

analysis plan. Shortly to say: How to perform the data collection and analysis of your own study project. (This course can be the

continuation of the “Data analysis 1” course however someone can complete these two courses on a reversed order as well. The main

reason of this flexibility is, that many students are asking for help when they have already had their data at hands (at least partially), and

this course is processing the steps from this point of the job. Even though, it is beneficial for the students doing this course first to

complete the Data analysis 1 course later. They can do it next year for example - so to understand the preliminary steps of a research

work: How to make a research plan?)

This course is also based on the medical papers. Students may pick the appropriate data collection methods and recognize the critical

points of this process based on the most fundamental papers of their own research field. They can learn from the most rewarded experts

on this way. From a paper you may extract the principles as well as you can follow immediately the realization. It is an excellent way to

learn the methodology. You may even learn from the errors.

The same way is followed for the data analysis and making conclusions. Every student will do his/her own data analysis based on their

own plan.

Students will have all help to the practical evaluation of their own data and making the right conclusion. The steps and results will be

discussed and improved by a class discussion.

Conditions for acceptance of the semester

Maximum 1 lesson absence.

Mid-term exams

Evaluate your data step by step and present it to the group weekly.

Making up for missed classes

One extra class

Reading material

- Obligatory literature

1-3 medical papers brought by each student (from library, from your department or from the tutor of your thesis).

- Literature developed by the Department

Supporting materials (papers, posters, research reports, ...) supplied by the tutor of the classes.

- Notes

- Recommended literature

Any statistical books.

Lectures

1 Introduction. Find a paper to process. Prepare or present your own data collection plan.

Dr. Pótó László

2 The realization of the data collection - examples are based on papers

Dr. Pótó László

3 The preliminary data preparations for the following statistical analysis.

Dr. Pótó László

4 Do your own statistical analysis 1-2: - select the right methods, - interpret the results.

Dr. Pótó László

5 Make your conclusion and share the results with the others.

Dr. Pótó László

6 Summary. Consolidation and evaluation of the results.

Dr. Pótó László

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Practices

1 Find a paper to process. Work on your own data collection plan.

Dr. Pótó László

2 Present the realization of the data collection - based on selected papers

Dr. Pótó László

3 Share your experiences on your preliminary data preparations - make corrections if needed.

Dr. Pótó László

4 Present your own statistical analysis - methods and results

Dr. Pótó László

5 Make your conclusion and share the results with the others.

Dr. Pótó László

6 Overview and summarize the results of the class.

Dr. Pótó László

Seminars

Exam topics/questions

Evaluate your data and submit your own results based on your active participation.

Participants

Dr. Pótó László (FIO4UU)

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OPE-T2F-T PHARMACEUTICAL BIOTECHNOLOGY AND ITS LINKS TO BIOPHARMACEUTICALS

Course director: DR. JUDIT ERZSÉBET PONGRÁCZ, professor

Department of Pharmaceutical Biotechnology [email protected]

3 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ autumn semester ▪ recommended semester: 7

Number of hours/semester: 28 lectures + 14 practices + 0 seminars = total of 42 hours

Course headcount limitations (min.-max.): 5 – 50 Prerequisites: none

Topic

The aim of this course is to introduce students to the science of pharmaceutical biotechnology and its links to biopharmaceuticals.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Writing test

Making up for missed classes

According to the Code of Studies and Examinations

Reading material

- Obligatory literature

- Literature developed by the Department

- Notes

Lecture notes, lecture materials available on MeetStreet

- Recommended literature

Lectures

1 Pharmaceuticals, biologics and biopharmaceuticals - link to Biotechnology. An introduction.

Dr. Kvell Krisztián

2 Protein structure and its importance of engineering biopharmaceuticals

Dr. Kvell Krisztián

3 Gene manipulation and recombinant DNA technology 1: Nucleic acid manipulation

Dr. Kvell Krisztián

4 Gene manipulation and recombinant DNA technology 2: Recombinant production of therapeutic proteins.

Dr. Kvell Krisztián

5 Gene manipulation and recombinant DNA technology 3: Nucleic acid manipulation.

Dr. Kvell Krisztián

6 Biotechnological methodology in drug development 1

Dr. Pongrácz Judit Erzsébet

7 Biotechnological methodology in drug development 2

Dr. Pongrácz Judit Erzsébet

8 Biotechnological methodology in drug development 3

Dr. Pongrácz Judit Erzsébet

9 Sources and upstream processing 1

Dr. Pongrácz Judit Erzsébet

10 Sources and upstream processing 2

Dr. Pongrácz Judit Erzsébet

11 Downstream processing 1

Dr. Járomi Luca

12 Downstream processing 2

Dr. Járomi Luca

13 Product analysis

Dr. Járomi Luca

14 The cytokines: the interferon family

Dr. Járomi Luca

15 Cytokines: Interleukin and tumor necrosis factor

Dr. Járomi Luca

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16 Growth factors

Dr. Pongrácz Judit Erzsébet

17 Therapeutic hormones

Dr. Pongrácz Judit Erzsébet

18 Recombinant blood proteins and therapeutic enzymes

Dr. Pongrácz Judit Erzsébet

19 Antibodies in diagnostics and therapy

Dr. Pongrácz Judit Erzsébet

20 Vaccines and adjuvants

Dr. Pongrácz Judit Erzsébet

21 Vaccine production

Dr. Pongrácz Judit Erzsébet

22 Nucleic acid-based therapeutics. Gene therapy.

Dr. Kvell Krisztián

23 Nucleic acid-based therapeutics. Recombinant viruses in cancer therapy.

Dr. Pongrácz Judit Erzsébet

24 Cell-based therapeutics

Dr. Kvell Krisztián

25 Test systems for toxicology

Dr. Járomi Luca

26 Test systems for efficacy

Dr. Járomi Luca

27 Nanotechnology

Dr. Pongrácz Judit Erzsébet

28 Legal aspects of healthcare-related Biotechnology

Dr. Pongrácz Judit Erzsébet

Practices

1 Principals of gene cloning - using the NCBI database

2 Cloning a specific gene - a practical approach 1

3 Cloning a specific gene - a practical approach 2

4 Cloning a specific gene - a practical approach 3

5 Culturing organisms for protein production

6 Culturing organisms for protein production

7 Selection and application of organisms for protein production

8 Protein purification for therapeutic application 1

9 Protein purification for therapeutic application 2

10 Technical approach for monoclonal antibody production 1

11 Technical approach for monoclonal antibody production 2

12 Testing toxicity using methodology of biotechnology

13 Efficacy testing using methodology of biotechnology

14 Nanotechnological methods

Seminars

Exam topics/questions

MeetStreet

Participants

Dr. Járomi Luca (FBC8DT), Dr. Kvell Krisztián (Y0GLOV)

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OPE-SHK-T DESIGN AND INDUSTRIAL MANUFACTURE OF MEDICINES

Course director: DR. SZILÁRD PÁL, assistant professor

Institute of Pharmaceutical Technology and Biopharmacy [email protected]

2 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ autumn semester ▪ recommended semester: 7

Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours

Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPG-BFR-T completed + OPG-C2E-T completed

Topic

During the course, the process of the design of modified drug delivery systems is acquired by the students based on the theory and

practice of biopharmaceutical including examinations of dosage forms. The course consists of theoretical lectures and seminars.

Conditions for acceptance of the semester

- participation on the lectures

- accepted work reports

- accepted written assessments

Mid-term exams

Students have to write an end-semester assessment from the lectures at acceptance level of 60%.

Making up for missed classes

Students must fulfil requirements determined by the Code of Studies and Examinations. Student has make up for the missed lectures and

work reports.

Reading material

- Obligatory literature

- Literature developed by the Department

- Notes

- Recommended literature

Leon Shargel, A. B.C. Yu, Stamford: Applied Biopharmaceutics and Pharmacokinetics

Susanna Wu-Pong, Yon Rojanasakul: Biopharmaceutical Drug Design and Development, Humana Press

Gilbert S. Banker, Christopher T. Rhodes: Modern Pharmaceutics, Marcel Dekker Inc., New York- Basel

Michael J. Rathbone, Michael S. Roberts: Modified-Release Drug Delivery Technology, Informa Healthcare

Michael E. Aulton: The Design and Manufacture of Medicines, Churchill Livingstone

Lectures

1 Floating drug delivery, Targeted Drug Delivery Systems

Dr. Pál Szilárd

2 Floating drug delivery, Targeted Drug Delivery Systems

Dr. Pál Szilárd

3 Floating drug delivery, Targeted Drug Delivery Systems

Dr. Pál Szilárd

4 Floating drug delivery, Targeted Drug Delivery Systems

Dr. Pál Szilárd

5 Introduction of modified drug delivery

Dr. Kása Péter

6 Introduction of modified drug delivery

Dr. Kása Péter

7 Introduction of modified drug delivery

Dr. Kása Péter

8 Introduction of modified drug delivery

Dr. Kása Péter

9 Targeted Drug Delivery Systems

Dr. Secenji Aleksandar

10 Targeted Drug Delivery Systems

Dr. Secenji Aleksandar

11 Targeted Drug Delivery Systems

Dr. Pál Szilárd

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12 Targeted Drug Delivery Systems

Dr. Pál Szilárd

13 Pulsative Drug Delivery Systems

Dr. Pál Szilárd

14 Pulsative Drug Delivery Systems

Dr. Pál Szilárd

15 Pulsative Drug Delivery Systems

Dr. Pál Szilárd

16 Pulsative Drug Delivery Systems

Dr. Pál Szilárd

17 Dissolution, lecture and practice

Ámanné Dr. Takácsi-Nagy Anna

18 Dissolution, lecture and practice

Ámanné Dr. Takácsi-Nagy Anna

19 Dissolution, lecture and practice

Dr. Pál Szilárd

20 Dissolution, lecture and practice

Dr. Pál Szilárd

21 From molecule to the preparition

Dr. Kása Péter

22 From molecule to the preparition

Dr. Kása Péter

23 From molecule to the preparition

Dr. Pál Szilárd

24 From molecule to the preparition

Dr. Pál Szilárd

25 3D printing in pharmaceutical technology

Dr. Pál Szilárd

26 3D printing in pharmaceutical technology

Dr. Pál Szilárd

27 Assessment

Dr. Pál Szilárd

28 Assessment

Dr. Pál Szilárd

Practices

Seminars

Exam topics/questions

Students can get the test topics in the institute or download the from website of the institute.

Participants

Dr. Dévay Attila (BSX334), Dr. Pál Szilárd (FYF5E9)

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OPF-KIA-T ESSENTIAL OILS AND CLINICAL AROMATHERAPY

Course director: DR. GYÖRGYI HORVÁTH, associate professor

Department of Pharmacognosy [email protected]

2 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 7

Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours

Course headcount limitations (min.-max.): 3 – 50 Prerequisites: OPG-O1E-T completed + OPG-O2E-T completed

Topic

Essential oils (EOs) are very interesting natural products and among other qualities they possess various biological properties. The term

biological comprises to all activities that these mixtures of volatile compounds (mainly mono- and sesquiterpenoids, phenylpropanoids,

etc.) exert on humans. EOs are used for their therapeutic action, for flavouring, in perfumery, or as starting materials for the synthesis of

other compounds. For therapeutic purposes they are administered as inhalations (e.g. eucalyptus oil), orally (e.g. peppermint oil) and

transdermally (e.g. rosmary oil). Oils with a high phenol content, for instance thyme and clove, have antiseptic properties, whereas others

are used as carrminatives. Oils showing antispasmodic activity, and much used in popular medicine, are those of melissa, peppermint,

chamomile, fennel, caraway and orange. Furthermore, in traditional medicine, EOs are also well-known for their analeptic, antimicrobial,

antinociceptive, antiphlogistic, antioxidative and sedative activities. All terpenoids easily enter the human body by oral absorption,

penetration through the skin, or inhalation very often leading to measurable blood concentrations. The aim of this course is to introduce

the most important medicinal plants containing essential oils and their medicinal role in the therapy and the clinical aromatherapy. We

would like to highlight their appropriate use, their profiles, but to call students’ attention to the cautions and contraindications of EOs, as

well.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Two written exams during the semester, acceptance of them from 60%.

Making up for missed classes

There is no possibility.

Reading material

- Obligatory literature

- Literature developed by the Department

PowerPoint presentations prepared by lecturers.

- Notes

- Recommended literature

1. Evans W.C.: Trease and Evans Pharmacognosy, Saunders, London, New York, 2000

2. Tisserand R., Balacs T.: Essential Oil Safety: A Guide for Health Care Professionals, Churchill Livingstone, 1995

3. Tisserand R., Young R: Essential Oil Safety: A Guide for Health Care Professionals, Second edition, Churchill Livingstone, 2013

Baser C.H, Buchbauer G.: Handbook of Essential Oils. Science, Technology and Application. CRC Press, Boca Raton, 2010

Lectures

1 Introduction of the course requirements. Definition of aromatherapy and clinical aromatherapy.

Dr. Horváth Györgyi

2 Advantages and disadvantages of the application of essential oils.

Dr. Horváth Györgyi

3 History of the use of essential oils.

Dr. Horváth Györgyi

4 Biological activities of essential oils.

Dr. Horváth Györgyi

5 Sources of essential oils.

Dr. Horváth Györgyi

6 Chemistry of essential oils. Chemical composition of essential oils.

Dr. Horváth Györgyi

7 Extraction techniques of essential oils: water-steam distillation, enfleurage, expression, supercritical fluid extraction. Gas

chromatographic analysis of essential oils.

Dr. Horváth Györgyi

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8 Extraction techniques of essential oils: water-steam distillation, enfleurage, expression, supercritical fluid extraction. Gas

chromatographic analysis of essential oils.

Dr. Horváth Györgyi

9 Drugs containing essential oils in the European Pharmacopoeia and in the ESCOP Monograph.

Dr. Horváth Györgyi

10 Quality of essential oils according to the official Pharmacopoeias.

Dr. Horváth Györgyi

11 External application of essential oils.

Dr. Horváth Györgyi

12 The most important base oils.

Dr. Horváth Györgyi

13 Physiological effects of essential oils. Metabolism of essential oil components in animal models and humans.

Dr. Horváth Györgyi

14 Contraindications.

Dr. Horváth Györgyi

15 Written test I

Dr. Horváth Györgyi

16 Written test I

Dr. Horváth Györgyi

17 Antimicrobial activity of essential oils. In vitro methods.

Dr. Horváth Györgyi

18 Antimicrobial activity of essential oils. In vivo methods.

Dr. Horváth Györgyi

19 Description of essential oils I: their main components and medicinal use. Peppermint oil, lemon oil, citronella oil, pine oil,

lavender oil.

Dr. Horváth Györgyi

20 Description of essential oils I: their main components and medicinal use. Peppermint oil, lemon oil, citronella oil, pine oil,

lavender oil.

Dr. Horváth Györgyi

21 Description of essential oils II: their main components and medicinal use. Clary sage oil, rosemary oil, tea tree oil, clove oil,

thyme oil, chamomile oil.

Dr. Horváth Györgyi

22 Description of essential oils II: their main components and medicinal use. Clary sage oil, rosemary oil, tea tree oil, clove oil,

thyme oil, chamomile oil.

Dr. Horváth Györgyi

23 Description of essential oils II.: their main components and medicinal use. Cinnamon oil, bitter and sweet orange oil, anise oil,

carraway oil, eucalyptus oil, sweet fennel oil, spearmint oil.

Dr. Horváth Györgyi

24 Description of essential oils II.: their main components and medicinal use. Cinnamon oil, bitter and sweet orange oil, anise oil,

carraway oil, eucalyptus oil, sweet fennel oil, spearmint oil.

Dr. Horváth Györgyi

25 Safety guidelines of essential oils.

Dr. Horváth Györgyi

26 Safety guidelines of essential oils.

Dr. Horváth Györgyi

27 Written test II

Dr. Horváth Györgyi

28 Written test II

Dr. Horváth Györgyi

Practices

Seminars

Exam topics/questions

There is no list. The questions of the written test is similar to the lecture topics.

Participants

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OPF-XES-T THE FATE OF DRUG

Course director: DR. ORSOLYA RIDEG, research associate professor

Department of Pharmaceutical Biotechnology [email protected]

1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 7

Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours

Course headcount limitations (min.-max.): 3 – 25 Prerequisites: OGG-R1E-T completed

Topic

By the end of the course, the students get an outlook on the history and basics of genetics and pharmacogenetics.They get an outlook on

the newest methodical aspects of genetic variants and enzyme function. By discussing certain clinical cases (mostly clinical cases from

the central nervous system, pulmonology, and hepatology) students get an outlook on the importance and complexity of the area.

Conditions for acceptance of the semester

Maximum of 15 % absence allowed

Mid-term exams

One test at the end of the course.

Making up for missed classes

No option for supplement.

Reading material

- Obligatory literature

- Literature developed by the Department

Educational material in PDF

- Notes

- Recommended literature

Genetic Variation: Methods and Protocols; Barnes Michael R.; Springer

Concepts and tools in Pharmacogenomics - FDA

Principles of Pharmacogenetics and Pharmacogenomics; Rus B. Altman;Cambridge

Lectures

1 Basics on Genetics and Pharmacology, History of Pharmacogenetics

Dr. Rideg Orsolya

2 Basics on Genetics and Pharmacology, History of Pharmacogenetics

Dr. Rideg Orsolya

3 Fate of Drugs-CYP metabolization (classification, genetic background, function)

Dr. Rideg Orsolya

4 Fate of Drugs-CYP metabolization (classification, genetic background, function)

Dr. Rideg Orsolya

5 Expression and regulation of xenobiotic Metabolizing Cytochrome P450 Enzymes in the Liver

Dr. Rideg Orsolya

6 Expression and regulation of xenobiotic Metabolizing Cytochrome P450 Enzymes in the Liver (case study)

Dr. Rideg Orsolya

7 Expression and regulation of xenobiotic Metabolizing Cytochrome P450 Enzymes in the Central Nervus System

Dr. Rideg Orsolya

8 Expression and regulation of xenobiotic Metabolizing Cytochrome P450 Enzymes in the Central Nervus System (case study)

Dr. Rideg Orsolya

9 Expression and regulation of xenobiotic Metabolizing Cytochrome P450 Enzymes in the Lung

Dr. Rideg Orsolya

10 Expression and regulation of xenobiotic Metabolizing Cytochrome P450 Enzymes in the Lung (case study)

Dr. Rideg Orsolya

11 Role of CYP genepolymorphisms’ in neurological and cardiological diseases.

Dr. Rideg Orsolya

12 Methodical aspects of genetic variants

Dr. Rideg Orsolya

13 Methodical aspects of enzyme function.

Dr. Rideg Orsolya

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14 Test

Dr. Rideg Orsolya

Practices

Seminars

Exam topics/questions

Participants

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OPE-DRO-T DRUG AND SUBSTANCE ABUSE

Course director: DR. ERIKA SÁNTICS-PINTÉR, professor

Department of Pharmacology and Pharmacotherapy [email protected]

1 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ spring semester ▪ recommended semester: 8

Number of hours/semester: 12 lectures + 0 practices + 0 seminars = total of 12 hours

Course headcount limitations (min.-max.): 5 – 30 Prerequisites: OPG-D1E-T completed

Topic

The course aimed to provide general terms of drug and substance abuse and present its physiological and biochemical background. We

are going to review systematically the most important pharmacological features of the drugs of abuse, the symptoms, dangers and possible

treatments of abuse. The drugs are discussed in the following sections: opioids, anxiolytics, sedatohypnotics, inhalants, alcohol,

psychomotor stimulants (amphetamin and derivates, cocain, coffein, nicotin), psychedelics and hallucinogens (LSD, mescalin,

phencyclidin), cannabis. After the discussion of pharmacology the participants can hear about the practical problems of drug abuse. At

the end of the course the students should present 5-10 minute ppt presentations from different abuse-related topics.

Conditions for acceptance of the semester

Maximum of 15 % absence allowed

Mid-term exams

There is no possibility.

Making up for missed classes

There is no possibility.

Reading material

- Obligatory literature

- Literature developed by the Department

Uploaded on the Neptun

- Notes

- Recommended literature

Lectures

1 General terms of drug abuse, definition of dependence and tolerance

Sánticsné Dr. Pintér Erika

2 General terms of drug abuse, definition of dependence and tolerance

Sánticsné Dr. Pintér Erika

3 Opioid abuse

Dr. Horváth Ádám István

4 Abuse of anxiolytics and sedatohypnotics. Inhalants.

Dr. Horváth Ádám István

5 Alcohol abuse

Dr. Horváth Ádám István

6 Abuse of psychomotor stimulants

Dr. Horváth Ádám István

7 Psychedelics, hallucinogens, cannabis

Sánticsné Dr. Pintér Erika

8 Designer drugs

Sánticsné Dr. Pintér Erika

9 Practical problems of drug abuse

Dr. Szemelyácz János

10 Practical problems of drug abuse

Dr. Szemelyácz János

11 Presentations of students

Sánticsné Dr. Pintér Erika

12 Written exam

Sánticsné Dr. Pintér Erika

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Practices

Seminars

Exam topics/questions

1. General terms of drug abuse, definition of dependence and tolerance

2. Opioid abuse

3. Abuse of anxiolytics and sedatohypnotics. Inhalants.

4. Alcohol abuse

5. Abuse of psychomotor stimulants

6. Psychedelics, hallucinogens, cannabis

7. Designer drugs

Participants

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OPE-MGT-T PHARMACEUTICAL TECHNOLOGY OF MODIFIED DRUG RELEASE

Course director: DR. SZILÁRD PÁL, assistant professor

Institute of Pharmaceutical Technology and Biopharmacy [email protected]

1 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ spring semester ▪ recommended semester: 8

Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours

Course headcount limitations (min.-max.): 1 – 50 Prerequisites: OPG-C4E-T parallel

Topic

Students can get acquainted in details with modified drug delivery technologies and special industrial drug manufacture (3D printing,

manufacture of multi-layer tablets and osmotic preparations) and the importance of pharmaceutical excipients. Student will learn special

manufacturing technologies through the demonstration of dosage forms already available in the pharmaceutical therapy.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

During the end semester test 60 % should be reached.

Making up for missed classes

According to the Code of Studies and Examinations

Reading material

- Obligatory literature

- Literature developed by the Department

- Notes

- Recommended literature

James Swarbrick: Encyclopedia of Pharmaceutical Technology, Informa Healthcare, 2011

Lectures

1 Theory of modified drug release

Dr. Pál Szilárd

2 Importance of excipients, patents of excipient-compositions

Dr. Kása Péter

3 Immediate drug-release (OraSolv, DuraSolv, Zydis technology)

Dr. Pál Szilárd

4 Sustained drug-release: Multiparticulate dosage forms I. (sustained release pellets in practice)

Dr. Pál Szilárd

5 Multiparticulate dosage forms II. (MUPS technology)

Dr. Pál Szilárd

6 Matrix systems I. (hydrophilic matrices)

Dr. Pál Szilárd

7 Matrix systems II. (hydrophobic matrices)

Dr. Pál Szilárd

8 Osmotic technology (EOP, OROS, L-OROS, GITS)

Dr. Pál Szilárd

9 Geometry based drug-release (Geomatrix, Procise, Smartrix technology)

Dr. Kása Péter

10 Chronotherapeutic systems (Geoclock technology)

Dr. Pál Szilárd

11 3D printing in the field of modified drug delivery

Dr. Pál Szilárd

12 Site specific drug release (gastroretentive systems, colon-specific drug delivery)

Dr. Pál Szilárd

13 Halving of tablets, technology of halving-friendly tablets, concept of ,,ghost” tablets

Dr. Kása Péter

14 End-year test

Dr. Pál Szilárd

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Practices

Seminars

Exam topics/questions

http://gytk.pte.hu

Participants

Dr. Kása Péter (ISWPRM), Dr. Pál Szilárd (FYF5E9)

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OPE-FAJ-T PAIN AND ANALGESICS

Course director: DR. GÁBOR ISTVÁN PETHŐ, professor

Department of Pharmacology and Pharmacotherapy [email protected]

1 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ spring semester ▪ recommended semester: 8

Number of hours/semester: 12 lectures + 0 practices + 0 seminars = total of 12 hours

Course headcount limitations (min.-max.): 5 – 50 Prerequisites: OPG-D1E-T completed

The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

The aim of the course is to give an integrative overview on the physiological, pathophysiological and pharmacological aspects of pain.

Major tasks are to (i) provide information on peripheral and central mechanisms of pain and hyperalgesia; (ii) describe the major features

of existing analgesics including opioids, non-steroidal antiinflammatory agents and adjuvant analgesics; (iii) outline novel targets for

development of analgesic drugs. The course will also help students prepare for the exams in Pharmacology 2 and 3.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

After the last lecture of the course, a written test is taken in the instruction period to obtain a mid-semester grade. Those who fail or do

not write this test have a second chance until end of Week 12 of the instruction period to improve in form of an oral conversation. Upon

failing or missing there is one more oral chance to obtain a mid-semester grade during the first two weeks of the exam period.

Making up for missed classes

There is no way to make up for missed lectures.

Reading material

- Obligatory literature

None.

- Literature developed by the Department

The material of the lectures is available in PDF format in the Neptun.

- Notes

None.

- Recommended literature

None.

Lectures

1 Basic terms related to pain and nociceptors

Dr. Pethő Gábor István

2 Features of capsaicin-sensitive nociceptors

Dr. Pethő Gábor István

3 Peripheral mechanisms of hyperalgesia

Dr. Pethő Gábor István

4 Central mechanisms of hyperalgesia and allodynia

Dr. Pethő Gábor István

5 Features of neuropathic pain

Dr. Pethő Gábor István

6 Pharmacology of opioid analgesics

Dr. Pethő Gábor István

7 Pharmacology of non-steroidal antiinflammatory analgesic drugs

Dr. Pethő Gábor István

8 Adjuvant analgesics

Dr. Pethő Gábor István

9 New targets for development of analgesics I

Dr. Pethő Gábor István

10 New targets for development of analgesics II

Dr. Pethő Gábor István

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Practices

Seminars

Exam topics/questions

No exam questions are given. The essay questions of the written exam are based on the material presented.

Participants

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OPE-IVF-T INFECTIONS AND IMMUNITY

Course director: DR. JÚLIA BARTHÓ-SZEKERES, professor

Department of Medical Biology and Central Electron Microscope Laboratory [email protected]

2 credit ▪ midsemester grade ▪ Elective subject for the Medical-biological module ▪ spring semester ▪ recommended semester: 8

Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours

Course headcount limitations (min.-max.): 2 – 25 Prerequisites: OPO-IMM-T completed + OPO-MI1-T completed

The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

The importance of anti-infectious immunity is not restricted to elimination of pathogens, but is also responsible for long lasting protection,

as well as -in some cases- immunopathological disorders

Conditions for acceptance of the semester

Maximum of 15 % absence allowed

Mid-term exams

Continuous

Making up for missed classes

Consultation

Reading material

- Obligatory literature

- Literature developed by the Department

Lecture slides

- Notes

- Recommended literature

1. H. Chapel, M. Haeney, N. Misbah, Snowden: Clinical Immunology, Blackwell, 2008

2. S. Kartikeyan, R.N. Bharmal, R.P. Tiwari, and P.S. Bisen: HIV and AIDS: Basic Elements and Priorities, 2007

3. T. Platts-Mills and Johannes Ring: Allergy in Practice, 2003

Lectures

1 Non-specific defence. Surface barriers, normal colonizing flora, phagocytosis, complement system.

Dr. Barthóné Dr. Szekeres Júlia

2 Non-specific defence. Surface barriers, normal colonizing flora, phagocytosis, complement system.

Dr. Barthóné Dr. Szekeres Júlia

3 Antigen presentation and recognition. Dendritic cells, pattern recognition receptors.

Dr. Barthóné Dr. Szekeres Júlia

4 Antigen presentation and recognition. Dendritic cells, pattern recognition receptors.

Dr. Barthóné Dr. Szekeres Júlia

5 Defence against extracellular microorganisms. The role of immunoglobulin classes. Mucosal immunity.

Dr. Barthóné Dr. Szekeres Júlia

6 Defence against extracellular microorganisms. The role of immunoglobulin classes. Mucosal immunity.

Dr. Barthóné Dr. Szekeres Júlia

7 Defence against intracellular microorganisms. Defence against viral infections. Viruses and immunosuppression.

Dr. Barthóné Dr. Szekeres Júlia

8 Defence against intracellular microorganisms. Defence against viral infections. Viruses and immunosuppression.

Dr. Barthóné Dr. Szekeres Júlia

9 Defence against parasitic infections. Micro-and macroparasite infections that polarize the immune response.

Dr. Barthóné Dr. Szekeres Júlia

10 Defence against parasitic infections. Micro-and macroparasite infections that polarize the immune response.

Dr. Barthóné Dr. Szekeres Júlia

11 Evasion and use of the innate and adaptive immune responses by microorganisms.

Dr. Barthóné Dr. Szekeres Júlia

12 Evasion and use of the innate and adaptive immune responses by microorganisms.

Dr. Barthóné Dr. Szekeres Júlia

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13 Healing of infectious diseases. The pathogenic role of anti-infectious immunity; local inflammation, systemic inflammation,

sepsis, endotoxin shock, toxic shock syndrome.

Dr. Barthóné Dr. Szekeres Júlia

14 Healing of infectious diseases. The pathogenic role of anti-infectious immunity; local inflammation, systemic inflammation,

sepsis, endotoxin shock, toxic shock syndrome.

Dr. Barthóné Dr. Szekeres Júlia

15 The pathogenic role of anti-infectious immunity; hypersensitivity reactions in bacterial-parasitic and fungal infections.

Dr. Barthóné Dr. Szekeres Júlia

16 The pathogenic role of anti-infectious immunity; hypersensitivity reactions in bacterial-parasitic and fungal infections.

Dr. Barthóné Dr. Szekeres Júlia

17 Induction of autoimmunity; molecular mimicri, epitope spreading, polyclonal T or B cell activation.

Dr. Barthóné Dr. Szekeres Júlia

18 Induction of autoimmunity; molecular mimicri, epitope spreading, polyclonal T or B cell activation.

Dr. Barthóné Dr. Szekeres Júlia

19 Immunopathological alterations following viral infections. The involvement of CD8+ T cells.

Dr. Barthóné Dr. Szekeres Júlia

20 Immunopathological alterations following viral infections. The involvement of CD8+ T cells.

Dr. Barthóné Dr. Szekeres Júlia

21 Immunopathological alterations following viral infections. The involvement of CD4+ T cells.

Dr. Barthóné Dr. Szekeres Júlia

22 Immunopathological alterations following viral infections. The involvement of antibodies.

Dr. Barthóné Dr. Szekeres Júlia

23 Vaccination; Type of vaccines, requirements for vaccines.

Dr. Barthóné Dr. Szekeres Júlia

24 Vaccination; rational vaccine development, mandatory vaccines.

Dr. Barthóné Dr. Szekeres Júlia

Practices

Seminars

Exam topics/questions

The same as lecture topics

Participants

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OPF-GTH-T GENE THERAPY

Course director: DR. GÉZA SÁFRÁNY, visiting professor

Institute of Laboratory Medicine [email protected]

1 credit ▪ midsemester grade ▪ Optional subject ▪ spring semester ▪ recommended semester: 8

Number of hours/semester: 12 lectures + 0 practices + 0 seminars = total of 12 hours

Course headcount limitations (min.-max.): 3 – 30 Prerequisites: none

Topic

We wish to give a short overview about the present state of gene therapy, the current ongoing clinical trials and the potential side effects

of gene therapy and about the ethical considerations. The various viral and non-viral gene delivery protocols suitable for high efficiency

gene delivery both under in vitro and in vivo conditions will be discussed in details. Gene therapy protocols applied in the treatment of

malignant diseases will be presented together with the results of ongoing clinical trials. We will talk about the results and the potentials

of the treatments of inherited genetic disorders. One of the most promising field of the current clinical trials is the treatment of ischemic

diseases, the results will be presented. The potential applications of stem cells during gene therapy will be described, as well. Finally, we

will discuss the side effects occurring during gene therapy and the ethical considerations will also be mentioned.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Test

Making up for missed classes

Joining later lectures, individual consultations.

Reading material

- Obligatory literature

1. Kelly K. Hunt, Stephan A. Vorburger and Stephen G. Swisher (ed.): Gene Therapy for Cancer, 2007 Humana Press Inc. 999

Riverview Drive, Suite 208 Totowa, New Jersey 07512

2. Thomas F. Kresina (ed.): Introduction to Molecular Medicine and Gene Therapy, 2001 by Wiley-Liss, Inc. ISBNs: 0-471-39188-

3 (Hardback); 0-471-22387-5 (Electronic)

- Literature developed by the Department

1. Sáfrány G.: A génterápia génsebészeti alapjai és jelenlegi helyzete, A Genom (ed.: Hídvégi EJ), Budapest, Széphalom

Könyvműhely 2003, pp 187-204

2. Sáfrány G.: A vasculáris génterápia és a csontvelőőssejt-terápia, Atherosclerosis (ed.: Császár A.), Budapest, Synergo Kiadó,

2004 pp 336-344

- Notes

- Recommended literature

http://www.genetherapynet.com/clinicaltrialsgov.html

http://www.bioportfolio.com/cgi-bin/acatalog/Human_Gene_Therapy_Course.html

http://openlearn.open.ac.uk/course/view.php?id=2430

Lectures

1 Introduction to gene therapy, ongoing clinical trials

Dr. Sáfrány Géza

2 Gene delivery protocols, viral vectors applied in gene therapy

Dr. Sáfrány Géza

3 Targeted gene delivery and targeted gene expression

Dr. Sáfrány Géza

4 Application of dendritic cells in gene therapy

Dr. Sáfrány Géza

5 Gene directed enzyme pro-drug therapy of malignant diseases

Dr. Sáfrány Géza

6 Immune therapy of malignant diseases

Dr. Sáfrány Géza

7 Gene therapy of leukaemia

Dr. Sáfrány Géza

8 Treatment of immune-deficiencies with gene therapy

Dr. Sáfrány Géza

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9 Gene therapy of ischemic diseases

Dr. Sáfrány Géza

10 Gene therapy of cystic fibrosis

Dr. Sáfrány Géza

11 Gene therapy of thalassemia

Dr. Sáfrány Géza

12 Oncolytic viruses in tumor therapy

Dr. Sáfrány Géza

Practices

Seminars

Exam topics/questions

Multiple choice tests for checking the acquisition of course material is given at the end of semester. Questions include material discussed

in lectures and seminars.

Participants

Dr. Sáfrány Géza (UYX8V2)

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OPE-GST-T SPECIAL FIELDS OF PHARMACOLOGY

Course director: DR. GÁBOR ISTVÁN PETHŐ, professor

Department of Pharmacology and Pharmacotherapy [email protected]

1 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ autumn semester ▪ recommended semester: 9

Number of hours/semester: 10 lectures + 0 practices + 0 seminars = total of 10 hours

Course headcount limitations (min.-max.): 5 – 50 Prerequisites: OPG-D1E-T completed

The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

The aim of the course is to present those fields of pharmacology that are not covered at all or only partially discussed in the compulsory

courses Pharmacology 1-2-3 because of time limits. These are the following: use of drugs during pregnancy and lactation; significance

of pharmacogenomics in therapy and drug development, pharmacology of retinoids; other drugs used in dermatology; use of meta-

analysis in evaluation of drugs, clinical significance of basic pharmacodynamic and pharmacokinetic parameters; special aspects of drugs

used by inhalation, basics of chronopharmacology; pharmacology of contrast media, drugs and chirality. The course wishes to contribute

to a better understanding of the use of drugs in the clinical practice and may help students prepare for the pharmacology exams.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

After the last lecture of the course, a written test is taken in the instruction period to obtain a mid-semester grade. Those who fail or do

not write this test have a second chance until the end of Week 12 of the instruction period to improve in form of an oral conversation.

Upon failing or missing there is one more oral chance to obtain a mid-semester grade during the first two weeks of the exam period.

Making up for missed classes

There is no way to make up for missed lectures.

Reading material

- Obligatory literature

None.

- Literature developed by the Department

The material of the lectures is available in PDF format in the Neptun.

- Notes

None.

- Recommended literature

None.

Lectures

1 Special aspects of use of drugs during pregnancy and lactation

Dr. Pethő Gábor István

2 Significance of pharmacogenomics in therapy and drug development

Dr. Pethő Gábor István

3 Use of meta-analysis in evaluation of drugs

Dr. Pethő Gábor István

4 Drugs and chirality

Dr. Pethő Gábor István

5 Clinical significance of pharmacodynamic and pharmacokinetic parameters on the example of drugs used in respiratory diseases I

Dr. Pethő Gábor István

6 Clinical significance of pharmacodynamic and pharmacokinetic parameters on the example of drugs used in respiratory diseases II

Dr. Pethő Gábor István

7 Pharmacology of retinoids

Dr. Pethő Gábor István

8 Drugs (other than retinoids) used in dermatology

Dr. Pethő Gábor István

9 Pharmacology of contrast media

Dr. Pethő Gábor István

10 Basics of chronopharmacology

Dr. Pethő Gábor István

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Practices

Seminars

Exam topics/questions

No exam questions are given. The essay questions of the written exam are based on the material presented.

Participants

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OPE-GSI-T PHARMACEUTICAL INFORMATICS (ONLY FOR YEAR OF 2009 AND 2010)

Course director: DR. LAJOS BOTZ, professor

Department of Pharmaceutics and University Pharmacy [email protected]

2 credit ▪ midsemester grade ▪ Elective subject for the Pharm. theor. and pract. skills module ▪ autumn semester ▪ recommended semester: 9

Number of hours/semester: 12 lectures + 12 practices + 0 seminars = total of 24 hours

Course headcount limitations (min.-max.): 5 – 50 Prerequisites: OPG-U3E-T completed

Topic

Students will become familiar with pharmaceutical databases, IT communication systems and drug management software applications.

Pharmaceutical IT methods such as telemedicine, or Internet pharmacies will be also covered in lectures. Lectures will give students

insight into ethical and legal aspects of information sources, and their critical evaluation. The aim of the lectures is to consolidate the

pharmaceutical IT skills of students. Students will be equipped with up-to-date pharmaceutical IT skills: use of databases and Internet

information sources.

During the semester the students will become familiar with the basics of personal computer and network systems in general and with the

specifications of pharmaceutical informatics, such as the development and stages of pharmacy informatics, principles of pharmacy

softwares. Also the different software types and drug dispensing rules used in pharmacies are introduced in this semester. The basic

knowledge of drug interactions and the available techniques and databases for screening interactions in everyday practice is also an

emphasized topic. After acquiring the principles of informatics and pharmaceutical informatics the students will be able to synthesize the

elements and understand the functions of pharmacy information management systems. Even the possibilities and threats of online drug

marketing and the capability of finding relevant and authentic pharmaceutical information on the web is the objective of this course.

Conditions for acceptance of the semester

Acceptance of term/semester (provisions of casting to examination):

- Regular attendance of classes (maximum 25 % of absence is accepted),

- Assignments given in class should be carried out during term-time and,

- Written mid-term and end-of-the term test.

Mid-term exams

Mid-term tests: During the semester a mid-term test will be written. In case of unsuccessful or missed test, additional questions will be

added to the end-of-the-term test. The number of additional questions may vary regarding the number of unsuccessful or missed mid-

term tests. There is no re-examination opportunity for the unsuccessful or missed mid-term tests.

End-of-the-term test: On the last week of the semester, a test will be written on the whole semester”s curriculum. Further additional

questions are included in the end-of-the-term test, if the student has not carried out an assignment during the semester. The number of

these questions may vary according to the unsuccessful or missed assignments. In case of unsuccessful or missed end-of-the term test,

one re-examination opportunity is granted to make up until the end of the second week of the exam period. In case of Pharmaceutical

Informatics there is midsemester grade.

Making up for missed classes

Retake opportunity is possible following personal discussion for the end-of-the term test.

Reading material

- Obligatory literature

- Literature developed by the Department

List of study aids to acquire curriculum (books, notes, other) and all presentations can be downloaded from Neptun Meet Street.

- Notes

- Recommended literature

Ed. R. Fisher: Information Technology for Pharmacists, Pharmaceutical Press

Brent I. Fox, Margaret R. Thrower, Bill G. Felkey: Building Core Competencies in Pharmacy Informatics, American Pharmacists

Association, 2010

Lectures

1 Personal computer and network system fundamentals 1.

Dr. Vida Róbert György

2 Personal computer and network system fundamentals 2.

Dr. Vida Róbert György

3 Database systems, IT and search engines 1.

Dr. Vida Róbert György

4 Database systems, IT and search engines 2.

Dr. Vida Róbert György

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5 Drug interactions, Drug interaction databases 1.

Dr. Végh Anna

6 Drug interactions, Drug interaction databases 2.

Dr. Végh Anna

7 Drug interactions, Drug interaction databases 3.

Dr. Végh Anna

8 Drug interactions, Drug interaction databases 4.

Dr. Végh Anna

9 Pharmaceutical Information Management Systems 1.

Dr. Fittler András Tamás

10 Pharmaceutical Information Management Systems 2.

Dr. Fittler András Tamás

11 Midterm test

Dr. Fittler András Tamás

12 End-of-the term test

Dr. Vida Róbert György

Practices

1 Evidence Based Medicine - Critical Appraisal.

2 Evidence Based Medicine: Outcome Measures.

3 Evidence Based Medicine: Calculations.

4 Evidence Based Medicine: Interpretation of results. Practice

5 Central Clinical Pharmacy Oncology laboratory visit 1.

6 Central Clinical Pharmacy Oncology laboratory visit 2.

7 UNIV Pharmacy On site visit 1.

8 UNIV Pharmacy On site visit 2.

9 Pharmaceutical Information Management Systems 3.

10 Pharmaceutical Information Management Systems 4.

11 Midterm test

12 End-of-the term test

Seminars

Exam topics/questions

Based on the topics of the lectures and seminars.

Participants

Dr. Fittler András Tamás (IYR5HQ), Dr. Vida Róbert György (BN08GS)

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OPF-SUO-T EMERGENCY MEDICINE

Course director: DR. PÉTER LÁSZLÓ KANIZSAI, associate professor

Department of Emergency Medicine [email protected]

1 credit ▪ midsemester grade ▪ Optional subject ▪ autumn semester ▪ recommended semester: 9

Number of hours/semester: 12 lectures + 0 practices + 0 seminars = total of 12 hours

Course headcount limitations (min.-max.): 5 – 150 Prerequisites: OPO-KL1-T completed

The subject can only be registered in case of a PASSED and valid health aptitude test!

Topic

It is prudent to understand the emergency concept for health care providers not involved in acute care. The purpose of the subject is to

understand the aims and principles of emergency care, to get familiar with emergency approach based on focused assessment and care,

risk stratification. It is also important to understand the essences of team approach and make patients comfortable by providing safe and

patient centered care within our given time-range, i.e. 24 hours.

Conditions for acceptance of the semester

Test exam.

Mid-term exams

Making up for missed classes

Personal communication with the tutors.

Reading material

- Obligatory literature

R. Aghababian: Essentials of Emergency Medicine, 2nd edition

- Literature developed by the Department

- Notes

- Recommended literature

Lectures

1 History of emergency care, emergency aspects, structured communication

Dr. Kanizsai Péter László

2 Prehospital care

Dr. Bóna Ernő

3 Triage, teamwork

Dr. Gaál Ildikó

4 Emergency group of symptoms

Dr. Szilágyi Csilla

5 Pain syndromes

Dr. Labudek Renáta

6 From door to needle (ACS and stroke care - emergency aspects)

Dr. Merész Márton

7 Environmental emergencies

Dr. Borbély Andrea Ágnes

8 Care of the severely injured

Dr. Gaál Ildikó

9 Paediatric emergency care

Dr. Bánfai Gábor László

10 Toxicology basics

Dr. Bóna Ernő

11 Sepsis in the emergency department

Dr. Kanizsai Péter László

12 Interactive consultation between the Hungarian university emergency departments

Dr. Kanizsai Péter László

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Practices

Seminars

Exam topics/questions

Website of Emergency Medicine, University of Pécs.

Participants