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Microbiology Lecture: Antimicrobial Therapy and Drug ResistanceSpring 2016
I. The Fundamentals of Antibiotic Therapy
a. Selective Toxicity
b. Limited Spectrum of Activity
c. Bacteriostatic or Bacteriocidal
II. Mechanisms of Actiona. Cell Wall Synthesis
The New Kid on the block – Teixobactin (January 2015)
b. Membrane Integrity
c. Metabolism i. Sulfa Drugs
d. DNA Synthesis and Integrity
i. Quinolones
ii. Metronidazole
e. Transcription Inhibitors
f. Translation Inhibitors
i. Drugs that affect the 30S subunit
ii. Drugs that affect the 50S subunit
III. Antibiotic Resistancea. Mechanisms
b. Multidrug Resistance
c. Development of Drug Resistancei. Overuse
ii. Improper Use
iii. Agricultural Use
d. Fighting Drug Resistance
i. Developing New Antibiotics1. Targeting Resistance Mechanisms
2. Development of New Antibiotic Classes
3. Using Genomics to Identify New Targets
ii. Blasts from the Past
iii. It Takes Two
iv. Strategies for Extending Antibiotic Lifetimes
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