synthesis of chiral drugs group members: lim seok ting 10s76 angie phua 10s7a
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Synthesis of Chiral Drugs
Group Members: Lim Seok Ting 10S76
Angie Phua 10S7A
What is our project about?
Synthesis of Phytophthora insect mating hormone
Phytophthora: devastating plant pathogens Causes substantial yield losses in agricultural
crops worldwide
What is our project about? (Cont’d)
Synthetic insecticide that can effectively kill pests
Hormone introduced during sexual reproduction of Phytophthora
20-step complex process Unique insecticide: exhibits various chiral
properties and chiral centres
Introduction to Experimental Techniques and Equipment
Thin Layer Chromatography (TLC)
Similar to paper chromatography Carried out on a piece of glass coated with a
thin layer of silica gel Technique used to separate mixtures and
identify compounds Used to monitor reactions
VS
Pencil Line
Reactant Spot
Co-spot Spot
Product Spot
Monitoring Reactions
Reactants Product
How It Works?
Different compound have different solubility in various solvents (Hexane : Ethyl Acetate 1:1)
Silica Gel – SiO2
Si-O Bonds – Polar Substance is highly polar interact with
silica gel travel a shorter distance Substances non-polar travel a longer
distance up TLC plate
Flash Column Chromatography
Used to purify chemical compounds, isolate desired products from mixtures (usually carried out after TLC analysis)
Utilizes a glass column filled silica gel Sample to be separated placed on top Flushed with solvent (hexane: EA 1:2) External pressure applied solvent runs
through the column compounds become separated
Experimental Setup
Stationary Phase
Mobile Phase
How it Works?
Stationary Phase VS Mobile Phase Individual components are retained by the
stationary phase differently separate from each other while running at
different speeds through the column. At the end of the column, they elute one at a
time. Eluent is collected in a series of fractions.
Rotary Evaporator
Used for removal of solvents from samples (usually done after Column Chromatography)
Via Evaporation and Condensation Low pressures in evaporator lowers boiling point of
solvents
Video for simplicity
http://www.youtube.com/watch?v=dKQIdSDso5E&feature=related
Further research work
Ongoing research work
Continue attachment at NTU (Nov-Dec)
Focus on synthesis of mating hormone using 20-step process
THE END
Thank you!
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