voltaren and cataflam voltaren and cataflam tehran, iran dr. narges alavi, brand manager

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Voltaren and Voltaren and Cataflam Cataflam Tehran, Iran

Dr. Narges Alavi, Brand Manager

Agenda

| Presentation Title | Presenter Name | Date | Subject | Business Use Only2

Differentiation between Voltaren & Cataflam

Indications ( Acute & Chronic Pain)

Voltaren Messages

Cataflam Messages

Dosage forms

Prices

ClassClass

- Diclofenac Sodium, a derivative of phenyl acetic acid.

Properties

| Presentation Title | Presenter Name | Date | Subject | Business Use Only5

Inhibits prostaglandin (PG) biosynthesis. PGs largely contribute to causation of inflammation, pain and fever.

A non-steroidal compound with pronounced anti-rheumatic, anti-inflammatory, analgesic and antipyretic properties.

Voltaren In Rheumatic Disease

| Presentation Title | Presenter Name | Date | Subject | Business Use Only6

Gives marked relief from:

- Pain at rest. - Pain on movement.

- Morning stiffness. - Swelling of joints.

2. Provides an improvement of function.

E.C.Tabs Suppos. SR 100 Injection

Mean peak plasma after

1.5 mcg/ml (50 mg) 2 hours

1.5 mcg (50 mg) 1 hour

0.43 mcg/ ml (100 mg) 5 hours

2.5 mcg/ml 75 mg) 20 minutes

A U C Half that of the injection Double that of other forms

Protein binding 99.7% (chiefly to albumin 99.4%)

Total Systemic Clearance

263 + 56 ml / min

Term. Plasma Half-life 1 - 2 hours

Enters Synovial Fluid (S.F.)

2 - 4 hours after peak plasma concentration is attained.

Apparent Half-life of Elim-ination from S.F.

3-6 hours i.e. only 4-6 hours after administration, concentrations of diclofenac sodium are higher in the S.F. than those in plasma. They remain higher for up to 12 hours.

Excretion

60% in the urine (< 1% unchanged) 40% in the faeces

Kinetics of the different Kinetics of the different dosage formsdosage forms

Voltaren Indications in CHRONIC pain

| Presentation Title | Presenter Name | Date | Subject | Business Use Only8

Inflammatory and degenerative forms of rheumatism.

Rheumatoid arthritis.

Osteoarthritis & Spondylarthritis.

Juvenile Rheumatoid Arthritis.

Ankylosing Spondylitis.

Voltaren Dosage

| Presentation Title | Presenter Name | Date | Subject | Business Use Only9

Ideal daily dose: 150 mg.

Long term Therapy: 75-100 mg daily

In 2 - 3 fractional doses or once daily

Starting dose: 100-150 mg daily (in milder cases: 75-100 mg daily)

Voltaren forms in IranVoltaren forms in Iran

Voltaren Retard 100mg

Voltaren SR 75mg

Voltaren EC 50mg

40 years More than billion

patients use.

In more than 140 countries

Voltaren Messages

| Presentation Title | Presenter Name | Date | Subject | Business Use Only12

Demonstrated in over 3900 trials which make it the standard reference drug for testing new NSAIDs.

Continues to demonstrate a favourable safety profile

Wide range of forms & strengths.

The original one from the house of NSAIDs.

Concentrations in synovial fluid are higher than concentrations in the plasma & remain higher for up to 12 hrs.

Has a strong analgesic effect.

13

CATAFLAM

Cataflam Class

| Presentation Title | Presenter Name | Date | Subject | Business Use Only14

It belongs to the NSAID’s class. “diclofenac potassium, a derivative of phenylacetic acid”.

Cataflam Indications In ACUTE Pain

| Presentation Title | Presenter Name | Date | Subject | Business Use Only15

CATAFLAM will be positioned as the FAST RELIEF for Non-Rheumatic Pain indication

1.URTI

2.Sprain & Strain.

3.Dental Pain

4.Dysmenorrhea

16 Cataflam 50 | Business Use Only-

Mean Peak Plasma After 3.8 µmol/L reached in 20-60 MinAUC Half That of Injection

Protein Binding 99.7% (Chiefly to Albumin :99.4%)

T 1/21-2 h

Site Of Inflammation 8-12 h

Excretion 60% Urine40% Faeces

CATAFLAM Pharmacokinetics

Rapid Pain Relief observed within 10 minutes with Cataflam

17

Cataflam Dosage

| Presentation Title | Presenter Name | Date | Subject | Business Use Only18

CATAFLAM 50 MG

2- 3 Tabs daily ( 100 – 150 mg) ( over 14 yrs ).

Before meals.

Forms: 20 tab

Cataflam for ACUTE PAIN & RAPID Pain Relief

19

Voltaren & Cataflam Price list

20

Thank you

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