voltaren and cataflam voltaren and cataflam tehran, iran dr. narges alavi, brand manager
Post on 19-Dec-2015
222 Views
Preview:
TRANSCRIPT
Voltaren and Voltaren and Cataflam Cataflam Tehran, Iran
Dr. Narges Alavi, Brand Manager
Agenda
| Presentation Title | Presenter Name | Date | Subject | Business Use Only2
Differentiation between Voltaren & Cataflam
Indications ( Acute & Chronic Pain)
Voltaren Messages
Cataflam Messages
Dosage forms
Prices
ClassClass
- Diclofenac Sodium, a derivative of phenyl acetic acid.
Properties
| Presentation Title | Presenter Name | Date | Subject | Business Use Only5
Inhibits prostaglandin (PG) biosynthesis. PGs largely contribute to causation of inflammation, pain and fever.
A non-steroidal compound with pronounced anti-rheumatic, anti-inflammatory, analgesic and antipyretic properties.
Voltaren In Rheumatic Disease
| Presentation Title | Presenter Name | Date | Subject | Business Use Only6
Gives marked relief from:
- Pain at rest. - Pain on movement.
- Morning stiffness. - Swelling of joints.
2. Provides an improvement of function.
E.C.Tabs Suppos. SR 100 Injection
Mean peak plasma after
1.5 mcg/ml (50 mg) 2 hours
1.5 mcg (50 mg) 1 hour
0.43 mcg/ ml (100 mg) 5 hours
2.5 mcg/ml 75 mg) 20 minutes
A U C Half that of the injection Double that of other forms
Protein binding 99.7% (chiefly to albumin 99.4%)
Total Systemic Clearance
263 + 56 ml / min
Term. Plasma Half-life 1 - 2 hours
Enters Synovial Fluid (S.F.)
2 - 4 hours after peak plasma concentration is attained.
Apparent Half-life of Elim-ination from S.F.
3-6 hours i.e. only 4-6 hours after administration, concentrations of diclofenac sodium are higher in the S.F. than those in plasma. They remain higher for up to 12 hours.
Excretion
60% in the urine (< 1% unchanged) 40% in the faeces
Kinetics of the different Kinetics of the different dosage formsdosage forms
Voltaren Indications in CHRONIC pain
| Presentation Title | Presenter Name | Date | Subject | Business Use Only8
Inflammatory and degenerative forms of rheumatism.
Rheumatoid arthritis.
Osteoarthritis & Spondylarthritis.
Juvenile Rheumatoid Arthritis.
Ankylosing Spondylitis.
Voltaren Dosage
| Presentation Title | Presenter Name | Date | Subject | Business Use Only9
Ideal daily dose: 150 mg.
Long term Therapy: 75-100 mg daily
In 2 - 3 fractional doses or once daily
Starting dose: 100-150 mg daily (in milder cases: 75-100 mg daily)
Voltaren forms in IranVoltaren forms in Iran
Voltaren Retard 100mg
Voltaren SR 75mg
Voltaren EC 50mg
40 years More than billion
patients use.
In more than 140 countries
Voltaren Messages
| Presentation Title | Presenter Name | Date | Subject | Business Use Only12
Demonstrated in over 3900 trials which make it the standard reference drug for testing new NSAIDs.
Continues to demonstrate a favourable safety profile
Wide range of forms & strengths.
The original one from the house of NSAIDs.
Concentrations in synovial fluid are higher than concentrations in the plasma & remain higher for up to 12 hrs.
Has a strong analgesic effect.
13
CATAFLAM
Cataflam Class
| Presentation Title | Presenter Name | Date | Subject | Business Use Only14
It belongs to the NSAID’s class. “diclofenac potassium, a derivative of phenylacetic acid”.
Cataflam Indications In ACUTE Pain
| Presentation Title | Presenter Name | Date | Subject | Business Use Only15
CATAFLAM will be positioned as the FAST RELIEF for Non-Rheumatic Pain indication
1.URTI
2.Sprain & Strain.
3.Dental Pain
4.Dysmenorrhea
16 Cataflam 50 | Business Use Only-
Mean Peak Plasma After 3.8 µmol/L reached in 20-60 MinAUC Half That of Injection
Protein Binding 99.7% (Chiefly to Albumin :99.4%)
T 1/21-2 h
Site Of Inflammation 8-12 h
Excretion 60% Urine40% Faeces
CATAFLAM Pharmacokinetics
Rapid Pain Relief observed within 10 minutes with Cataflam
17
Cataflam Dosage
| Presentation Title | Presenter Name | Date | Subject | Business Use Only18
CATAFLAM 50 MG
2- 3 Tabs daily ( 100 – 150 mg) ( over 14 yrs ).
Before meals.
Forms: 20 tab
Cataflam for ACUTE PAIN & RAPID Pain Relief
19
Voltaren & Cataflam Price list
20
Thank you
top related