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V O L U M I Z I N G B I O D E G R A D A B L E
I N J E C TA B L E I M P L A N T
O N T H E C U T T I N G E D G E O F S C I E N C E
A G A R O S E M O L E C U L E
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I N T R O D U C T I O N
While the demand for minimally invasive procedure treatments increases,
the fillers’ market is experiencing a growing number of publications of im-
mediate or latent reactions associated with Hyaluronic Acid (HA) fillers or
other chemically based fillers. Patients and the scientific community are
trending to natural and biocompatible dermal fillers without chemicals for
a safe and effective solution for consistently excellent outcomes.
In response to the physician and patient needs, Advanced Aesthetic
Technologies, Inc. (AAT), a Boston, MA USA based company, employing
bio-technologies in the aesthetic medical field, has launched Algeness®, the
100% natural and biodegradable injectable implant, the culmination of 10
years of scientific and clinical research.
W H A T I S A L G E N E S S ® ?
Algeness® is a biomaterial resulting from a sophi sticated manufacturing
process consisting of a purified agarose gel (polysaccharide), derived
from the purification of Agar-Agar processed from red algae. Totally
biocompatible to the human body and absorbable, Algeness®, does not
contain cross-linked synthetic chemicals (BBDE or PEG) associated with
Hyaluronic acid (HA) fillers and thus is 100% natural. The molecular and
biophysical properties of Algeness® make it a breakthrough in the filler’s
injection technology. For the first time in aesthetic medicine history, a 100%
natural, biodegradable and mouldable filler is available to the aesthetic market
for a more defined youthful look.
Algeness® agarose gel structure
Agarose is an hydrocolloid
molecule containing water in its structure
(1) i filler di gel di agarosio: studio istologico di biocompatibilita’ e interazione con le strutture cutanee umane. prof. alessio pirino, dr. giorgio maullu. dipartimento
di scienze biomediche, università di sassari (2) safety and efficacy of algeness® vs juvederm to treat the nasolabial fold. double-blind study giovanni montealegre
gómez m.d. plastic surgeon and microsurgeon. national university of colombia, bogotá. colombia
W H A T I S T H E S C I E N C E B E H I N D
A L G E N E S S ® A L L N A T U R A L B I O D E G R A D A B L E I M P L A N T ?
Algeness® is the culmination of 10 years of
scientific and clinical research to find the most
natural, biocompatible material to fill wrinkles
and compensate for volume loss in facial soft
tissues. Extensive research has been conducted
to master the correlation of the agarose struc-
ture and the physiological response; in fact,
utilizing different concentrations of agarose, it
was possible to obtain various three dimensio-
nal structures that interact differently with the
vital and functional parameters of the cell.
Agarose which is h ighly purified is free of any
protein, a source for most bacteria, making it
highly biocompatible. Formulations of agarose
form stable gels with small amounts of mate-
rial (1% of agarose and 99% saline water) and
does not require any added chemicals for cross
linking. Chemically, agarose is a polysaccharide
Being free from toxicity to micro-organisms
and free from impurities, Algeness® is well to-
lerated within the human body. This produc-
tion process is only achieved by a limited nu-
mber of highly specialized facilities. They have
the rights to international patents to produce
highly purified, high quality agarose under rigid
physical-chemical, and bacteriological controls,
as well as quality standards of ISO 13485 and
ISO 9001.
A L G E N E S S ® F I L L E R S D E P T H O F I N J E C T I O N
W H A T A R E T H E B E N E F I T S O F A L G E N E S S ®
A L L N A T U R A L V O L U M I Z I N G B I O D E G R A D A B L E I M P L A N T ?
n Hydrocolloid gel 100% biocompatible
and biodegradable(1).
n Immediate volumizing: “What you see
is what you get” The physician and the
patient can see and evaluate the result
of the injection immediately after the
procedure.
n No need to wait to see the hydrophi-
lic reaction associated with all HA fillers
that can take 2-4 weeks for the full
effect to be realized.
n Free of solvents and chemicals; all
natural.
n Long lasting results remaining over
12 months proven by clinical studies(2).
n Non allergenic; Algeness® offers ex-
cellent tolerability and biocompatibility
with a negligible immunological reaction(1).
n Minimal irritation & inflammation
due to the absence of foreign body
reactions(1).
n Extremely low migration, the product
stays where it has been injected with
excellent persistence.
2,5%Agarose (High density)
Deep sub-dermal
3,5%Agarose (High density)
hypo-dermis and supra peri-osteal
SUPERFICIAL
HYPODERMIS
MUSCLE
DERMIS
DEEP
HYPODERMIS
BONE
1,5%Agarose (Low density)Sub-dermal
1%Agarose (Low density)Sub-dermal
S C I E N T I F I C A N D C L I N I C A L R E S E A R C H
Currently there are several studies that were
published and there are a number of ongoing
and unpublished studies executed on the new
Algeness® injectable implant.
Wake Forest University in the United States
performed animal studies which were completed
in 2013 and 2014 with the 2.5% Algeness VL
and the 3.5% Algeness DF compared to HA
fillers. The Wake Forest comparative study
showed that after 6 months 2.5% and 3.5%
performed better compared to the other fillers,
showing Algeness® lasted longer, did not show
unpredictable changes due to inflammatory
reactions or water absorption, and exhibited less
migration.
Four clinical studies were conducted in Italy
and Denmark in 2006/2007 where Algeness®
performed well with minimal side effects and
no complication were reported. These studies
demonstrated the safety and efficacy of
Algeness® fillers.
Dr. Giovanni Montealegre, Professor of Plastic
Surgery at the National University of Colombia,
in Bogota, completed a 50 subjects study to
evaluate the safety and efficacy of Algeness® for
the correction of nasolabial folds in comparison
to Juvederm®. Both Juvederm® and Algeness®
have similar and comparable effects on safety
and duration. Algeness® offers excellent
tolerability and biocompatibility, is safe, natural
and has a negligible immunological reaction.
Over the first six months of observations, the
results are comparable with Juvederm®.
In 2017, a histological study to evaluate the
biocompatibility and the interactions between
Algeness Agarose Gel and human skin tissues
utilizing skin biopsies taken from human
volunteers has been conducted by Prof. Alessio
Pirino and Dr. Giorgio Maullu in the department
of biomedical science at the University of Sassari
(Italy). The study demonstrates a homogeneous
integration of the filler into the hypodermis, with
a minimal physiological inflammatory reaction
and no granulomatous activity, accompanied by
an increase in collagen formation.
In 2018 a 30 subjects study of the volumizing
effects of Algeness® and Voluma™ will
commence in Belgium with Dr. Joan Vandeputte,
in Italy, Dr. Giovanni Salti, and in Germany with
Dr. Tatjana Pavicic.
Also started other studies in process. Please
visit Algeness website www.algeness.com to
download studies
Dr. Ömer Buhsem Dr. Arna Shab Dr. Ömer Buhsem Dr. Joan Vandeputte Dr. Giorgio Maullu
T H E U L T I M A T E T E C H N I Q U E T O M A S T E R Y O U R R E S U L T S ®
A R E A S O F A P P L I C A T I O N
ALGENESS® LD 1%
Indications
n Tear trough
n Lips
Depth of injection:
subdermal
ALGENESS® HD 1.5%
Indications
n Marionette lines,
n wrinkles and furrows
n Lip augmentation
and contouring
n Oral commissure
n Oro-mandibular folds
Depth of injection:
subdermal
ALGENESS® VL 2.5%
Indications
n Medium-deep volumizing
n Wrinkles, furrows and folds
n Cheeks, jawline and chin
n Nasolabial folds temple
n Non-surgical rhinoplasty
Depth of injection:
supra-periosteal
Subcutaneous
ALGENESS® DF 3.5%
Indications
n Deep volumetric filling
n Cheeks, jawline and chin
n Malar-zygomatic arch
n Submalar
Depth of injection:
Subcutaneous
Supraperiosteal
MASTER YOUR RESULTS®
N AT U R A L Y O U T H F U L L O O K
W I T H I M M E D I AT E R E S U LT S
Product
Composition 1% Agarose (Very low density)99% sterile saline
1.5 % Agarose (Low density)98 .5% sterile saline
2.5% Agarose (High density)0.5% non crossed-linked HA97% sterile saline
3.5% Agarose (High density)0.4% non crossed-linked HA96.1% sterile saline
Indication Tear troughLips augmentation and contouring
Marionette lines, wrinkles, and furrowsLip augmentationand contouringOral commissureOro-mandibular folds
Medium-deep volumizingWrinkles, furrows and folds Cheeks, jawline and chin Nasolabial foldsMalar and SubmalarNon-surgical rhinoplasty
Deep volumetric fillingCheeks , jawline and chinNasolabial foldsMalar-zygomatic archSubmalarNon surgical nose rhinoplasty
Technique Linear,Retrograde
Linear,Retrograde
Linear,Retrograde
Linear,Retrograde
Injection depth
Immediately Subcutaneous
Immediately Subcutaneous
Subcutaneous Deep soft tissue supra-periosteal
Follow up After 7-10 days if additional corrections are required
After 7-10 days if additional corrections are required
After 7-10 days if additional corrections are required
After 7-10 days if additional corrections are required
Duration 3 – 4 months or more 4 – 8 months or more 8 – 12 months or more 10 – 15 months or more
Volume 1.4 ml 1.4 ml 1.4 ml 1.4 ml
Needle size 30 G 30 G 27G 27G
Each boxcontains
2 disposable “full-use” 1.4 ml double Luer Lock syringe systems, 2 needles per syringe.
2 disposable “full-use” 1.4 ml double Luer Lock syringe systems, 2 needles per syringe.
2 disposable “full-use” 1.4 ml double Luer Lock syringe systems, 2 needles per syringe.
2 disposable “full-use” 1.4 ml double Luer Lock syringe systems, 2 needles per syringe.
Shelf life 2 years 2 years 2 years 2 years
LD1%
CharmHD
1,5%VL
2,5%DF
3,5%
IMMEDIATE VOLUMIZING:
[ WHAT YOU SEE
IS WHAT YOU GET ]
THE PHYSICIAN
AND THE PATIENT
CAN SEE AND EVALUATE
THE RESULT
OF THE INJECTION
IMMEDIATELY
AFTER THE PROCEDURE.
HYDROCOLLOID GEL
BIOCOMPATIBLE
AND BIODEGRADABLE.
100%
Q&AQ. What is the difference with
other fillers?
A. Unlike all other fillers,
Ageness® is 100% natural and
biodegradable. Algeness®
achieves its volumizing youth-
ful effects without the require-
ment of any added chemicals,
solvents or cross-linked agents
and is completely and safely
absorbed over time by the bo-
dy’s natural mechanisms.
Q. What areas could be proble-
matic using Algeness®?
A. Never inject Algeness® su-
perficially. It is strongly recom-
mended not to use Algeness®
fillers in the dermis.
Q. Into which layers of the
skin is it possible to inject
Algeness®?
A. The higher concentration
Algeness® biodegradable
implant should be injected
deeply and never superficially.
We therefore suggest that the
Algeness® VL and Algeness®
DF only be used in the subder-
mal, subcutaneous or suprape-
riosteal spaces.
Q. Is there a difference in the
injecting technique between
Algeness® and HA?
A. There is a slight difference
in the injectability of HA versus
Algeness® due to the difference
in density of the material and
the depth of the injection.
Algeness® is injected deeply
and slowly. A thorough mas-
sage is performed to shape the
product, avoid formation of
lumps and obtain the desired
immediate result.
Q. Is it possible to inject Alge-
ness® in an area where other
filler was injected previously?
A. We see no reason why
Algeness® cannot be used in
an area where other injectables
have been injected. Howe-
ver, this needs to be studied
further.
Q. Is it painful?
A. All injections cause a sense
of pain; however, the physician
may decide to apply anesthetic
cream to the injection site to
numb the area.
Q. What kind of result can the
patient expect?
A. Algeness® subcutaneous fil-
ler is able to achieve a youthful
and natural look by filling-out
lines around the mouth, the
naso-labial fold as well as chin
augmentation, correction of
nose imperfections and rede-
sign the jaw line. It can also
re-plump your lips and add
volume and lift to your cheeks.
Q. How long will it last?
A. Algeness® corrective effects
typically last for about 12 mon-
ths or longer depending on the
injection amount and depth of
injection.
Q. What are the side effects?
A. Depending on the area
injected, the procedure is
relatively painless, although
there may be some mild dis-
comfort during treatments to
the sensitive nose or lip areas.
There may be some redness
around the site of injection for
1-2 days. Thanks to its unique
all natural bio-compatibility,
post-treatment allergic reac-
tions are minimized.
Q. What is the recovery time?
A. Treatment times may vary
from 20-25 minutes, depen-
ding on the correction level
requested by the patient. The
recovery time can be from
a few hours to several days
depending on the area treated.
Usually, patients receiving
Algeness® treatments return to
normal activities straight after
injection.
Q. What is the difference
between Algeness and other
HA fillers?
A. Algeness is the only all-na-
tural gel implant. No HA filler
is all natural, they all contain
chemicals for the cross-linkage
that the body does not absorb.
So it builds up creating latent
complications that is underre-
ported by the manufacturers.
Algeness does not have che-
micals and therefore does not
have this type of complication.
THE ALGENESS® UNIVERSE
B R O C H U R E
C A M P A I G N B T O C A D V E R T I S I N G D I G I T A L & P R I N T
P O S T E R S
N E W S L E T T E R T R A I N I N G
M A N U A L
S P E C I A L A L G E N E S S
Y O U T U B E C H A N N E L
P R E S E N C E O N S O C I A L
N E T W O R K S
T R A I N I N G M A N U A L O N L I N E
P A T I E N T
B R O C H U R E
A L G E N E S S P H O T O A P PW E B S I T E
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F I L L E R O N T H E C U T T I N G E D G E
O F S C I E N C E
M A S T E R YO U R R E S U LT S T M
V O L U M I Z I N G
WHAT YOU S EE IS WHAT YOU GET
M A S T E R YO U R R E S U LT S T M
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W Y S I W YG & 1 0 0 % N AT U R A L
R E S U LT
WHAT YOU S EE IS WHAT YOU GET
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M A S T E R YO U R R E S U LT S T M
YO U R R E S U LT S T M
M A S T E R
WHAT YOU S EE IS WHAT YOU GET
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M A S T E R YO U R R E S U LT S T M
WHAT YOU S EE IS WHAT YOU GET
A G A R O S E M O L E C U L A R
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R E D E S I G NYO U R B E A U T Y
M A S T E R YO U R R E S U LT S T M
WHAT YOU S EE IS WHAT YOU GET
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M A S T E R YO U R R E S U LT S T M
WHAT YOU S EE IS WHAT YOU GET
YO U T H F U L L O O K
W I T H I M M E D I AT E R E S U LT S
U N I Q U E
A d v a n c e d A e s t h e t i c T e c h n o l o g i e s , I n c
O n e B r o o k l i n e P l a c e , S u i t e 4 2 7 - B r o o k l i n e , M A 0 2 4 4 5 - U S A
w w w . a l g e n e s s . c o m - w w w . t r a i n i n g . a l g e n e s s . c o m - f i l l e r @ a l g e n e s s . c o m
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D I ST R I B U TO R STA M P
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