an integrated view into multivariate associations inferred from
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An Integrated View into Multivariate Associations Inferred from TCGA Cancer Data
Dick Kreisberg Institute for Systems Biology Shmulevich Group Nov 17, 2011
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Visual Analytics
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Emergent Technologies
• Browser-based Graphical Rendering – SVG, Canvas, WebGL, Flash
• Cloud Services – Highly available, scale-able
• NoSQL (Couch, Mongo, etc) – Adaptive data models
• Graph Databases (Neo4J, OrientDB) – Adaptive data relationships
• Graph Computation – Reasoning on the topology of the data
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Integrating Data Across Sources, Analyses, and Literature
http://explorer.cancerregulome.org
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Regulome Explorer Genome View –RF, Significant Pairs, Aggressiveness
Random Forest Analysis
Timo Erkkila
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Colorectal Aggressiveness Scoring
Vesteinn Thorsson
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All Pairs Significance
Sheila Reynolds, Thomas Robinson
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Exploring the Association Topology
Regulome Explorer Network View – Semantic, Protein Domain, RF Edges
Brady Bernard, Andrea Eakin
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Future Work
Graph Databases Graph Computation Network Topologies Explicit, Retrievable State User Data Import
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The project described was supported by Award Number U24CA143835 from the National Cancer Institute.
Hector Rovira Ryan Bressler Adam Norberg Thomas Robinson
Acknowledgements Protovis ExtJS Google Visualization API Cytoscape Web Neo4J Golem
Technologies Jake Lin Dick Kreisberg
Genome View
Andrea Eakin Brady Bernard
Network View
Vesteinn Thorsson Sheila Reynolds Timo Erkkila
Analysis
http://explorer.cancerregulome.org
Ilya Shmulevich