an ultrasensitive cmos magnetic biosensor array for point-of-care (poc) microarray application
DESCRIPTION
An Ultrasensitive CMOS Magnetic Biosensor Array for Point-of-Care (POC) Microarray Application. Motivation: PoC biosensing requires high sensitivity, high portability, low cost and low power . Applications: Medical Diagnosis (epidemic disease control…) - PowerPoint PPT PresentationTRANSCRIPT
An Ultrasensitive CMOS Magnetic Biosensor Array for Point-of-Care (POC) Microarray Application
Motivation: PoC biosensing requires high sensitivity, high portability, low cost and low power.
Applications: • Medical Diagnosis (epidemic disease control…) • Environmental Monitoring (pollution…)• Bio-warfare (lethal agents detection…)
Background: • Optical microarray bulky and expensive optics.• Existing magnetic sensors external B-field and costly post-processing.
Our Approach: Frequency shift magnetic-based biosensor No magnetic biasing and completely CMOS compatible
An Ideal PoC Sensor
Sensor Mechanism and System Architecture
Mechanism: Frequency Shift of the On-chip LC Oscillator
Sensitivity Improving: Diff. Sensing and On-chip Temp Ctrl σ∆f/f0=0.13ppm
Architecture: Down-Conversion and 8-Cell Array
Sensor SNR Optimization
DAC Tools: HFSS, Maxwell, Matlab / Ephysics / Spectre, UltraSim, Virtuso, Calibre
Sensor Inductor Geometry
Chip Microphotograph and Measurement Results
Summary: 2.95mm x 2.56mm in 130nm CMOS with 165mW
Magnetic Bead Sensing: A single 1μm bead
Actual DNA Sensing: 1n-Molar magnetically labeled DNA
The Most Sensitive CMOS Magnetic Biosensor