analysis of dielectrophoretic force by using comsolanalysis of dielectrophoretic force by using...
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Analysis of Dielectrophoretic Force by Using COMSOL
Department of Biomedical Engineering,Yonsei Universityy
Taewoo Lee
COMSOL CONFERENCE SEOUL 2013
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Prof. Han-Sung KimCompuater Aided Biomedical Engineering Lab.p g ghttp://cabe.yonsei.ac.kr
Prof. Sang Woo LeeNano Bio System Research LabNano Bio System Research Lab.http://nbsrl.yonsei.ac.kr
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Dielectrophoresis is a phenomenon in which a force is exerted on a dielectric particle when it is subjected to a non-uniform electric fielddielectric particle when it is subjected to a non-uniform electric field.
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OutputSide view
p
Ground
Cover glass Silicon rubber
Glass substrate Electrode Medium (Cells or Beads)
Cover glass Silicon rubber
Top view
Cells or BeadsCells or Beads
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Side view
Top view
SiO2 insulator Opening window
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Unit model for simulation
45μmElectrode without SiO2
(Opening window)
13μm
zx
y
Gap betweenthe electrodes
0μm
5μm
yxElectrode with SiO2-8μm
0μm-5μm 10μm
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Governing equations
• Dielectrophoretic (DEP) forcep
• Elecrohydrodynamic force
- Electrothermal force
• Gravitational & buoyant forcey
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COMSOL Multiphysics 3.5a
MEMS
ModuleElectrostatics Electrostatics
COMSOL
MultiphysicsHeat Transfer
Convection and
Conduction
MEMSMEMS
ModuleMicrofluidics
Incompressible
Navier-Stokes
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Results
• Slice: Temperature
• Arrow: Total heat flux
• Streamline: Velocity field
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Result – Positive DEP
l b h h l d• Equilibrium height: Particle radius
N1.47e-19
N2.87e-9
1e-19
1e-20
1e-10
1e-11
1e-21
1e-22
1e-12
1e-13
1.78e-23
z
5.92e-15
Equilibrium heighty
DEP force EHD force
Equilibrium height
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Result – Positive DEP
N
3.6e-10
N5.37e-10
y
2.7e-10
1.8e-10
Trapped position x
y
0.9e-10
7.26e-12
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Result – Negative DEP
l b h h f• Equilibrium height: Net force = 0
N1.34e-9
N6.17e-14
1e-9
1e-10
1e-14
1e-15
1e-11
1e-12
1e-16
1e-17
z
2.11e-15 8.11e-18
y
DEP force EHD force
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Result – Negative DEP
l b h h f• Equilibrium height: Net force = 0
DE
xy
Cxy
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Result – Negative DEP
9.6e-15
N1.26e-14
7.2e-15
4.8e-15
2 4e-15
xy
2.4e-15
4.67e-16
Dotted line ATrapped position
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Simulation vs. Experiment
Positive DEP
Negative DEPNegative DEP
5μm polystyrene beads
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CM factor (Cells vs. Beads)
CM factor
Cells
Beads
CM factor
Frequency
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DEP traps for single cell (B16F10)
Positive DEP force (3Vpp, 100kHz)Negative DEP force (3Vpp, 1kHz)
Positive DEP Trap in various window shapes
Rh b S HRhombus Square Hexagon
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ThankThankyouyou