analytical and post analytical errors in laboratory
TRANSCRIPT
![Page 1: Analytical and post analytical errors in laboratory](https://reader033.vdocument.in/reader033/viewer/2022061405/5870218b1a28ab7f428b80e7/html5/thumbnails/1.jpg)
ANALYTICAL AND POST-ANALYTICAL
ERROR IN CLINICAL CHEMISTRY
LABORATORYHanisha Erica P. Villaester, RMT
![Page 2: Analytical and post analytical errors in laboratory](https://reader033.vdocument.in/reader033/viewer/2022061405/5870218b1a28ab7f428b80e7/html5/thumbnails/2.jpg)
Analytical Errors
![Page 3: Analytical and post analytical errors in laboratory](https://reader033.vdocument.in/reader033/viewer/2022061405/5870218b1a28ab7f428b80e7/html5/thumbnails/3.jpg)
Analytical Errors• Test System Not Calibrated• Results reported when control results out of range• Improper measurements of specimens and/or reagents• Reagents prepared incorrectly• Reagents stored inappropriately or used after expiration
date• Instrument maintenance not dance• Dilution and pipetting errors
![Page 4: Analytical and post analytical errors in laboratory](https://reader033.vdocument.in/reader033/viewer/2022061405/5870218b1a28ab7f428b80e7/html5/thumbnails/4.jpg)
Analytical Errors
• Inaccuracy• Imprecision Errors• Insensitivity• Linearity Issues
![Page 5: Analytical and post analytical errors in laboratory](https://reader033.vdocument.in/reader033/viewer/2022061405/5870218b1a28ab7f428b80e7/html5/thumbnails/5.jpg)
Analytical Errors• Inaccuracy• Invalidates reference ranges and cut-off points• May lead to inappropriate therapy or failure to treat• May lead to misdiagnosis• May lead to failure to diagnose
• Imprecision Issues• Poor reproducibility invalidates patient monitoring using
laboratory results
![Page 6: Analytical and post analytical errors in laboratory](https://reader033.vdocument.in/reader033/viewer/2022061405/5870218b1a28ab7f428b80e7/html5/thumbnails/6.jpg)
Analytical Errors• Insensitivity
• A change in assay sensitivity leads to issue of detection• Affects robustness of results near the detection limit
• Linearity Issues• A clear understanding of the linearity of a method is essential to
ensure that grossly inaccurate results are not reported where there are high concentrations or activities of analytes
![Page 7: Analytical and post analytical errors in laboratory](https://reader033.vdocument.in/reader033/viewer/2022061405/5870218b1a28ab7f428b80e7/html5/thumbnails/7.jpg)
Post-Analytical Errors
![Page 8: Analytical and post analytical errors in laboratory](https://reader033.vdocument.in/reader033/viewer/2022061405/5870218b1a28ab7f428b80e7/html5/thumbnails/8.jpg)
Post-Analytical Error
• Transcription errors in reporting• Report sent to the wrong location• Report illegible• Report not sent
![Page 9: Analytical and post analytical errors in laboratory](https://reader033.vdocument.in/reader033/viewer/2022061405/5870218b1a28ab7f428b80e7/html5/thumbnails/9.jpg)
Summary• Pre-Analytical Errors• 46 – 68.2%• Insufficient sample• Sample condition• Sample handling• Incorrect Identification• Incorrect sample
• Analytical Error• 7 – 13.3 %• Equipment Malfunction• Sample Mix up• Interference
• Post-Analytical• 18.5 – 47 %• Reporting and Interpreting• Improper date entrye
![Page 10: Analytical and post analytical errors in laboratory](https://reader033.vdocument.in/reader033/viewer/2022061405/5870218b1a28ab7f428b80e7/html5/thumbnails/10.jpg)
Impact of Errors• Inadequate or improper patient care• Inconvenience to patient• Misdiagnosis• Harm to patient• Death
![Page 11: Analytical and post analytical errors in laboratory](https://reader033.vdocument.in/reader033/viewer/2022061405/5870218b1a28ab7f428b80e7/html5/thumbnails/11.jpg)
WHAT SHOULD WE DO?• Develop systematic workflow• Identify critical processes• Continuous monitoring• Predict accidental events so preparation may be ahead• Strengthen defences and decrease vulnerability
![Page 12: Analytical and post analytical errors in laboratory](https://reader033.vdocument.in/reader033/viewer/2022061405/5870218b1a28ab7f428b80e7/html5/thumbnails/12.jpg)
References• Odell, M. (Feb 2014). CSE Senior Design 1. Retrieved from
https://www.google.com.ph/url?sa=t&rct=j&q=&esrc=s&source=web&cd=35&cad=rja&uact=8&ved=0CDUQFjAEOB5qFQoTCNL0jbC99MYCFYUmlAodnY8CvQ&url=http%3A%2F%2Franger.uta.edu%2F~odell%2FCSE_4316_Senior_Design_I%2FCSE%25204316%2520Classic%2520Mistakes.ppt&ei=946yVZKdLIXN0ASdn4roCw&usg=AFQjCNFgWECvcwF_hLS-nwPKhoXuOs0cAA&bvm=bv.98476267,bs.1,d.c2E