analyzing yourhealthcare data fora better you0b804eb0-c448-4b7d... · proliferation of medical...

Analyzingyour healthcaredatafor abetteryou

KuldeepSinghRajput,Founder&ChiefExecutiveOfficer

50MORETHAN

%

OFTHEWORLDLIVESWITHCHRONICDISEASES

…trilliondollarproblem – economiccrisis

OfallAmericans50 andolder

outof HAVE7 10TWOORMOREchronichealthconditions.

Efficientlymanagingpeoplewithcomplexandchronicconditionsisamongthegreatestchallengesphysicians,healthsystems,andpayersface.

Biofourmisoverview|StrictlyConfidential|December,2017|Slide1

1K.A.Locher,R.A.Goodman,S.Posner,A.Parekh.2013.“MultipleChronicConditionsAmongMedicareBeneficiaries:State-levelVariationsinPrevalence,Utilization,andCost,2011.MedicareandMedicaidResearchReview3(3).

…thecomplexhealthconditionchallenge

H + $…arenearly1.5timesmorelikelytobere-hospitalizedwithin30days

…are4timesmorelikelytohaveanemergencyroomvisit

…cost5.5timesmoreforannualcarethanthosewithoutcomplexhealthconditions1

Peoplewithcomplexhealthchallenge:


870644700200

0

5,000

10,000

15,000

20,000

25,000

6,900

7,100

6,400

1,100

2,4142013Total

CAGR54.9%

21,5002018Total

40.6%

55.7%

61.6%

51.3%

CAGR

CAGR

CAGR

CAGRRevenu

es(U

S$m

illion)

2013 2018

NorthAmerica Europe Asia-Pacificregion Restoftheworld

SOURCE:Mobilehealthtechnologiesandglobalmarkets,BCCResearch,2014

Improvesoutcomes

Focussesonprevention

Promotepatientindependence

MinimizesAvoidableservice

use

GlobalmHealthMarketrevenues,2013– 2018(USDmillion)

mHealth enabling remotepatientmonitoring

CAGR:CompoundAnnualGrowthRate

427 $328 266NumberofDevices AveragePrice(USD) NumberofCompanies

Proliferationofmedicalwearables- 8xgrowthinwearablemedicaldevicesby2023Markettospikefrom$4.1bnto$41.8bninnext9years

SOURCE:Vandrico


AsophisticatedHIPAAcompliantpersonalizedhealthanalyticsplatformbasedonhumanphysiology.

introducingbiovitalsTM

biovitalsTM

biovitalsTM

learnsthecorrelationbetweenonesphysiologyandactivity

buildsadynamicallyvaryingpersonalizedbaseline

resultsinpersonalizedphysiologicalhealthmodel

signals/predictshealthdeterioration,healthimprovementandmedicationeffect

Data Insights Action


howitworks

biovitalsTM

deviceagnosticplatformAPIstopulldatafromFDA/CEmarkmedical

devices

HeartRate

Weight

Spo2

BloodPressure

RespirationRate

Electrocardiogram

Activity

Sleep

artificialintelligenceCognitiveenginetolearnindividualsphysiology

datafrombio-sensors

machinelearning/predictiveanalyticsDynamicallyvaryingpersonalizedbaselinewhichindicatesandpredictspatientshealth

deterioration,improvement oranysubtlechangesduetomedication

Biovitalsisastate-of-the-artanalyticsenginethatusesadvancedmachinelearningtoprovidepredictive,preciseandactionablehealthinsights

Patienthealthdeterioration

Biovitalsindex

HeartRate

SystolicBP

RespirationRate

Activity


Advancedsignalprocessingtoextract10+keyhealthparametersusingElectrocardiogram(ECG)andPhotoplethysmogram (PPG)

ArtificialIntelligenceenginewhichmodelstheinterplaybetweenvariousphysiologicalparameterstogenerateabiovitalsTM index

ThecardiacmoduleofbiovitalsTM unlocksthepotentialofECGandPPGbiosignalstointerpretandderivethefollowing:- Cardiacarrhythmias(AtrialFibrillation/Flutter)- QTandSTanalysis- VentricularandSupraventricularEctopy- Bradycardia- HeartRateVariability- RespirationRate/Depth- CardiacOutput&StrokeVolume- BloodPulseWave- PulseTransitTime- BloodPressurevariations- +31derivativeswhicharepredictorofcardiachealthdeterioration

BiovitalsTM indexdetectsthephysiologicaldeviationsfromonespersonalizedbaselinethatmayresultinwidearrayofhealthconditionslike:- CongestiveHeartFailure- Post-MI&Post-cardiacCatheterization- COPD- Hypertension- OSA- ChronicPainPhysiologicaldeviationsalsoindicateandmeasuretheinfluenceofmedicationonindividualsoverallhealth

iECGholtermonitorfromiHealthcombinedwithbiovitalsTMforautomatedinterpretationofelectrocardiogram

biovitalsTM featuresEnablingclinicians,researchers&pharmaceuticalstogetdeeperinsightsintoapatientwithanambulatorymonitorusing

cloud-basedHIPAAcompliantplatform

Allanalyticscaneasilybeexportedintoany3rd partyanalyticstoolsorapplicationusingourwelldocumentedAPIs


case #1BiovitalsIndexTM

HeartRate

RespirationRate

Activity

AFBurden

Weight

BloodPressure

Patient73 yearsoldWhitemale,NYHAIII(moderate),HTN,COPD,diabetes,andCAD

A11September

DischargedaftertreatmentforpulmonaryedemaDischarged:15Sep2017

HFevent18Sep– 24Sep

WorseningHeartFailurewithelevatednight-timeRRandHR/AF.GradualincreaseinweightandBP.

A HFevent B

B1October

AdmittedwithworseningHeartFailureandchestdiscomfort.NewdiagnosisofAtrialFibrillation.Discharged:6Oct2017

Discussion:WouldthepatientbediagnosedandtreatedearlierwithBiovitalsIndexTM?


beatHFTM end-to-endsolution

biovitalsTMPersonalizedpatientsinsights

beatHFTM isanend-to-endintegratedsolutionpoweredbybiovitalsTM toprovidehomemonitoringforat-riskambulatorycardiacpatientstopreventhospitalreadmissions

ClinicalgradeFDA-clearedwearablebio-sensorsforambulatorypatientmonitoring

iOS/Androidmobileapplicationforvitalsignsmonitoring,medicationmanagement,goalsetting(diet&activity),PROMsandsecureclinicalmessaging

Caregiver’splatformwithautomatedpatientriskstratificationbasedonthepredictedriskofhealthdeteriorationandin-depthinsightsintooverallphysiologyandlifestyle

BiovitalsTM analyticsenginewithreal-timephysiologicaldataprocessing

Aqualifiedteamoftrainedcardiacnursesand24/7clinicalcallcenterbeatHFTM platformcustomizedforpost-operativeambulatorymonitoringof

patientssufferingfromCongestiveHeartFailuretopreventhospitalreadmission

Patientwearablesandmobileapp Physiologicaldataprocessing 24/7cardiaccareteam MedicalPractice


casestudy:beatHF(N=79)Projecttitle:Post-acutepatientmonitoringwithheartfailureat-hometopreventavoidablehospitalreadmission;formembersfromProfMedandKeyHealthmedicalschemeinSouthAfrica.

biovitalsTM

ContinuousphysiologymonitoringusingEverion®MDandCardioStikEKGTM alongwithpatientmobileapp

Real-timeanalysisofhumanphysiologytopredictpatienthealthdeterioration

24/7clinicalcallcenterandcardiaccareteamenabledwithclinicaldashboardwithpatientinsights Practicingphysician/provider

6monthsprogramwithcontinuousmonitoring

Reimbursementbymedicalscheme

Weeklyhomevisitsbycardiacnurseforinitial30days

Monthlysubscriptionbasedpaymentmodel


casestudy:beatHF(N=79)Projecttitle:Post-acutepatientmonitoringwithheartfailureat-hometopreventavoidablehospitalreadmission;formembersfromProfMedandKeyHealthmedicalschemeinSouthAfrica.

biovitalsTM

ContinuousphysiologymonitoringusingEverion®MDandCardioStikEKGTM alongwithpatientmobileapp

Real-timeanalysisofhumanphysiologytopredictpatienthealthdeterioration

24/7clinicalcallcenterandcardiaccareteamenabledwithclinicaldashboardwithpatientinsights Practicingphysician/provider

6monthsprogramwithcontinuousmonitoring

Reimbursementbymedicalscheme

Weeklyhomevisitsbycardiacnurseforinitial30days

Monthlysubscriptionbasedpaymentmodel


TotalNo.ofhospitalizations(90daysmonitoringduration)

0TotalNo.ofERvisits

2TotalNo.ofinterventionbythecareteam

(90daysmonitoringduration)

100+Averagecompliancerateforphysiologymonitoring**

93%**93%compliancerateobservedforphysiologymonitoringusingwearablebiosensors:EverionMDandCardioStikEKG*Calculated at the biovitals index alert threshold of 0.4

case #2


A HFEvent1 HFEvent2

Patient 68yearsoldwhiteAfrikaansmale,ICM(EF=38%),NYHAIII,CABG,HTN,CKD,AF

A9Oct

Dischargedaftertreatmentfordiagnosedacutecoronarysyndrome,unstableangina&HFexacerbation.Discharged:9Oct2017

HFevent113Oct

InterventionbyCareteamMissedhismedicationFurosemide;forgottoreplenishhismedicine.

HFevent214Oct

InterventionbyCareteam:ERvisitPatientexperiencessevereSOBat-night.Outpatienttreatment/ER:Carloc25mg,Spiractin25mg,Furosemide40mg/4mlIV

B15Oct- Present

Newbaselinepost-intervention:Stablephysiology,goodmedicationcompliance,increaseinactivitylevels

B

targetmarkets

Post-cardiaceventcare Pharmaceuticalandresearchclinicaltrials

ClinicalInstitutes,WearableandIoTmedicaldevices

EnablingpayersandproviderstoproactivelymonitortheircardiacpatientsusingbeatTM to

preventhospitalreadmissions

Leveragingcontinuousphysiological&lifestyledatacombinedwithpersonalizedanalytics(BiovitalsTM)intoclinicaltrialsandresearchtogeneratenovel,

transformationalendpoints

Enablingwearableandbio-sensormanufacturingwithBiovitalsTM APIs/SDKstoenhancetheirproductoffering

usingourreal-timeopticalandelectricalbiosignalinterpretationandpersonalizedphysiologicalengine

B2B subscription basedbusinessmodel

End-to-endserviceAnintegratedsolutionwith24/7clinicalcareteam

SoftwareasaServiceOneormoreservicesaccessedusingBiovitalsTM API


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