and (10nm) rad (0.6nm) let (50nm)
DESCRIPTION
Fig 2. MCF7-AROM1 (ER+ HER2-). A. B. p=2.4 x 10 -5. p=2.2 x 10 -5. p=0.035. Fold change in cell number relative to control. Fold change in cell number relative to control. p=1.3 x 10 -5. AND (10nM) RAD (0.6nM) 4-OHT (5nM). AND (10nM) RAD (0.6nM) LET (50nM). - PowerPoint PPT PresentationTRANSCRIPT
AND (10nM)RAD (0.6nM)LET (50nM)
AND (10nM)RAD (0.6nM)4-OHT (5nM)
AND (10nM)RAD (0.6nM)LET (25nM)
AND (10nM)RAD (0.6nM)4-OHT (25nM)
E2 (0.01nM)RAD (0.6nM)4-OHT (10nM)
p=2.2 x 10-5
p=2.4 x 10-5
p=1.3 x 10-5
p=0.035
p=7.8 x 10-6
p=0.002
p=0.02p=0.0008
p=0.0001
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RAD(nM)
LET(nM)
Growth inhibition
CI ± SD Effect P-value
0.10.31.0
82473
50%75%90%
1.19 ± 0.320.52 ± 0.020.39 ± 0.01
antagonisticSynergySynergy
0.36<10-5
<10-5
RAD(nM)
Tam(nM)
Growth inhibition
CI ± SD Effect P-value
1.02.05.0
7.51844
50%75%90%
11.4 ± 2.82.8 ± 1.21.4 ± 1.0
antagonisticantagonisticantagonistic
0.0030.070.52
RAD(nM)
LET(nM)
Growth inhibition
CI ± SD Effect P-value
0.31.03.0
1443132
50%75%90%
0.6 ± 0.070.55 ± 0.020.76 ± 0.05
SynergySynergySynergy
0.008<10-5
0.001
RAD(nM)
Tam(nM)
Growth inhibition
CI ± SD Effect P-value
0.61.02.0
254476
50%75%90%
1.36 ± 0.240.71 ± 0.050.6 ± 0.01
antagonisticSynergySynergy
0.060.004<10-5
+--
+ + ++ +-- + +
+--
+ + ++ +-- + +
+--
+ + ++ +-- + +
+--
+ + ++ +-- + +
+--
+ + ++ +-- + +
RAD(nM)
Tam(nM)
Growth inhibition
CI ± SD Effect P-value
0.32.522
19
75
50%75%90%
9.9 ± 170.18 ± 0.3
0.01 ± 0.01
antagonisticSynergySynergy
0.420.01<10-5
LTED (ER++HER2++)
BT474-AROM3(ER+/HER2 amp)
MCF7-AROM1 (ER+ HER2-)
Fig 2
A B
C D
E