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ANGIOTENSIN II RECEPTOR

BLOCKERS

Prepared by:

Marie Joy Alteza

Ma. Cristina BragaisRoxanne De Vera

Mark Vincent Flores

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ANGIOTENSIN II RECEPTOR BLOCKERS

Are medications that block the action of

angiotensin II, permitting the blood vessels to

relax and dilate lowering the blood pressure.

They have effects similar to an ACE inhibitor

which is why they are often used when an

ACE inhibitor cannot be tolerated by patients.

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The ABRs include the following drugs:

Candesartan(Atacand) is used alone or as part

of combination therapy to treat hypertension.

Usual Dosage: 16-32 mg/d PO

Eprosartan(Teveten) is used alone or as part of

combination therapy to treat hypertension inadults.

Usual Dosage: 400-800 mg/d PO

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Valsartan(Diovan) can be used alone or as

part of combination therapy for hypertension

and for the treatment of heart failure in

patients who are intolerant to ACE inhibitors.

Usual Dosage: 80-320 mg/d PO

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Irbesartan(Avapro) isused on monotherapy in

the treatment ofhypertension but can becombined with other

antihypertensive ifneeded. It is also used toslow the progression ofkidney disease in

patients withhypertension and type 2diabetes.

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INDICATION

Hypertension

Congestive Heart Failure (CHF)

Atrial fibrillation Diabetic Neuropathy

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DRUG INTERACTIONS

Lithium

- Increase SE of Lithium.

Rifampin

- Reduces blood levels of Losartan

Fluconazole

- Decreases the effect of Losartan

Phenobarbital

- Decreases serum levels.

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CAUTIONS

Hepatic and Renal dysfunction

Hypovolemia

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NURSING RESPONSIBILITIES

Encourage the patient to implement lifestyle changes, includingwt.loss, smoking cessation, decrease alcohol and salt in the diet andincrease exercise.

Administer without regard to meals; give with food.

Ensure that the female patient is not pregnant before beginning

therapy and suggest the use of barrier contraceptives while she istaking this drug.

Find an alternative method of feeding the baby if the patient isnursing.

Monitor the patient carefully in any situation that might lead to a

drop in fluid volume. Provide comfort measure

Offer support and encouragement to help the patient deal with thediagnosis and the drug regimen.