www.invivosciences.com

Drug Discovery through 3D Engineered Tissue-Based Compound

Analysis

InvivoSciences

BIO International Conference

Ayla Annac, CEO, PresidentInvivoSciences, Inc.www.invivosciences.com

1

IVS Contributes Regenerative Medicine

Phenotypic Screening & Tissue Mechanics

Skeletal Muscle

Cardiac Muscle

Smooth Muscle

Fibrotic Tissue

Muscular dystrophy, Muscular atrophy, COPD

Cardiac fibrosis, Congestive heart failure

Hypertension

Cardiac fibrosis, Aging-associated fibrosis

Disease Examples

•Miniaturized engineered tissues for rapid compound screening

•Engineered tissues mimic physiological properties of target organs/tissues

•Assays for drug-induced changes in engineered tissues

•Compound screening for the diseases that impair organ/tissue mechanics

Tissue Types

IVS provides:

IVS focuses on:

2

cPersonalized Drug Development

Applications & Potential Customers

www.invivosciences.com 5

Table 1. Key Industry Parameters: Tissue Engineering and Stem Cell TherapeuticsWorldwide estimates (in millions) 2007 2011 FactorTotal sector activity $2400 $3600 1.5xTotal commercial stage spending $1600 $2820 1.8xTotal development stage spending $860 $780 0.9xNumber of FTEs (full time employee) 6100 13,810 2.3xCapital value of listed firms (36) $4700 $6580 1.4xNumber of companies 171 202 1.2xNumber of companies in commercial stage

47 62 1.3x

Number of companies providing services 44

Number of companies with products in clinical trials

57 60 1.1x

Growing Industry & Future Worldwide

Progress in the Tissue Engineering and Stem Cell Industry “Are we there yet?”Ana Jaklenec, Andrea Stamp, Elizabeth Deweerd, Angela Sherwin, and Robert Langer. Tissue Engineering Part B: Reviews. June 2012, 18(3): 155-166. doi:10.1089/ten.teb.2011.0553. Potential Customers

www.invivosciences.com 6

Source: MedMarket Diligence, LLC; Report #S520, "Tissue Engineering, Cell Therapy and Transplantation: Products, Technologies & Market Opportunities, Worldwide, 2009-2018."

www.invivosciences.com 7

Contact for both companies:

Ayla Annac, CEO InvivoSciences, Inc.aannac@invivosciences.com608-628-8035

Tetsuro Wakatsuki, CSO InvivoSciences, Inc.tetsuro@invivosciences.com608-566-6162

Thanks!

Introduction to Cook Pharmica

BIO International Conference

April 2013

COOK PHARMICA OVERVIEW

ABOUT COOK PHARMICA• Contract development and manufacturing organization (CDMO)

• Over 450 full-time employees

• Wholly-owned subsidiary of Cook Medical

• Legacy of life sciences innovation since 1963

• 2007 Facility of the Year Category Award Winner for Facility Integration

9

PART OF THE COOK GROUP

ABOUT COOK GROUP, INC.

10

FOCUSED ON GLOBAL MEDICAL SOLUTIONS

ABOUT COOK GROUP, INC.

11

COOK PHARMICA IS GROWING (QUICKLY!)

12

2013 PROJECTIONS:

Revenue Growth = 92%

Project Growth = 35%

Headcount Growth = __% (OR # TO BE ADDED)

COOK PHARMICA CAMPUS

BLOOMINGTON, IN

13

14

DIFFERENTIATION THROUGH INTEGRATION

Development Drug Substance

Drug Product Packaging

COMPELLING BUSINESS MODEL

Consolidate the product supply chain to a single location to simplify the process and reduce the cost and time of managing and manufacturing with multiple service providers.

SIMPLIFY YOUR SUPPLY CHAIN WITH:• ONE supplier to audit• ONE point-of-contact for everything• ONE quality system• ONE set of business practices• ONE contract• ONE world-class, FDA-licensed manufacturing facility

15

Cook Pharmica’ s partnership with Ivy Tech Bloomington

• Cook Pharmica and Ivy Tech’s biotechnology program are both established at the same time in year 2004

• Understanding and development of mutually beneficial partnership:

– Workforce development need (Cook Pharmica) – hiring of interns, technicians, and operators through Ivy Tech’s education programs (tuition reimbursement program)

– Curriculum development need (Ivy Tech) – jobs, tasks, and skills set assessment for new educational program development (course objectives and contents are developed based on essential skill sets required by the jobs at Cook Pharmica),

– Instructional need (Ivy Tech) – subject matter experts at Cook Pharmica taught Ivy Tech courses as adjunct faculty members (Cell Culture, Protein Purification, Safety and Regulatory Compliances, Biotechnology Manufacturing topics), at least 12 Cook Pharmica employees taught at Ivy Tech

• Guaranteed course quality: the most practical and needed education contents

• The instructors from Cook Pharmica provided Ivy Tech’s students with early career assessment and job interview opportunities

– So far, Cook Pharmica has offered 28 internship opportunities and hired 25 graduates

– Positions held by Ivy Tech graduates: Quality Control Technicians, Quality Assurance Assistants, Process Development Scientists, Manufacturing Operators, and Instrumentation Technicians.

16

David’s experience and future prospective as the HR director:

• Difficulty in identifying and recruiting talent and importance of homegrown workforce that will stay within the community (community college graduates)

• Background/experience of Ivy Tech graduates compared to traditional 4-year university graduates

• How Cook Pharmica’ s HR practice supports hiring of Ivy Tech graduates: career advancement opportunity for Ivy Tech graduates (example of Tony Roberts)

• What your career at Cook depends on: Performance, Interests, Business Need.

• Importance of soft skills

17

Kenneth E. Miller, Ph.D.Professor and Chair, Anatomy and Cell BiologyOklahoma State University Center for Health SciencesDiana Spencer, Ph.D.Biotechnology Coordinator, Associate ProfessorTulsa Community College SoutheastTulsa, OK

Downtown TulsaOSU-CHS

TCC-SE

14 miles

The National Science Foundation awarded a grant of $384,581 to Tulsa Community College for the Stimulating Enthusiasm, Exploration, and Discovery through Biotechnology Education (SEEDBEd) project.

The Oklahoma IDeA Network of Biomedical Research Excellence (OK-INBRE) is funded through the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH) ($0.5M)

In the fall of 2011, the Oklahoma IDeA Network of Biomedical Research Excellence (OK-INBRE) provided $33,867 to Tulsa Community College to support a supplemental grant, Sustaining Outreach of Learning Experiences in Biotechnology Education (SOLEBEd) under the direction of Dr. Diana Spencer

Factors for Success:RelationshipsSupportToursSymposia/SeminarsHiresReciprocal InstructionInternshipsReferralsArticulationsCollaboration

2003 - They say education is the lighting of a fire. If that’s true, doctoral candidate Diana Spencer has ignited many a bright flame. A high school anatomy and physiology teacher, she is on sabbatical from Jenks High School to earn her doctorate in biomedical sciences at the OSU Center for Health Sciences. Before she returned to school herself, she brought dozens of students through the doors of the OSU-CHS to show them what a medical school is all about.

Relationships

The National Science Foundation awarded a grant of $384,581 to Tulsa Community College for the Stimulating Enthusiasm, Exploration, and Discovery through Biotechnology Education (SEEDBEd) project.Advisory Committee – OSU-CHS members: Drs. Earl Blewett and Kenneth Miller

Support

Tours

Symposia/Seminars

Dr. Robert W. Allen, OSU-CHS

• Monthy Seminar Series, televised• Annual High School Extravaganza• Into a Molecular Future: Tulsa’s

Growth Opportunities in the New Sciences of Life-Bio-Nano

Hires

Miller lab, June 2009

Michael Anderson

Michael Anderson

Michael Anderson

Hires

Miller lab, October 2010

Michael Anderson

Reciprocal Instruction

Miller lab, October 2010

Heith Crosby

Michael Anderson

Reciprocal Instruction

Dusti Sloan, Assistant Professor of Biology, Teaching Cell Culture techniques. Dusti Sloan is currently a Ph.D. student in Biomedical Sciences at OSU-CHS

Dusti Sloan

Heith Crosby

Heith Crosby learning cell culture

Reciprocal Instruction

Heith Crobsy, PharmD., Ph.D. candidate, helping teach Molecular Techniques Class

Heith Crosby

Internships

ReferralsDonita Gray

Articulations

CollaborationsTCC SE Biotechnology Class

Peripheral Pain Mechanisms:

The Role of GlutamateKenneth E. Miller, PhD

Professor & Chair; Anatomy & Cell Biology Oklahoma State University Center For Health Sciences

Tulsa, OK

Kemmx Corporation, Sapulpa, OK

March 2013

Relationships

3. Are there specific Oklahoma companies that are incorporating bioscience innovations into their work?Oklahoma's bioscience sector continues to grow, with the combined direct and indirect impacts contributing $6.7 billion in economic activity in the region. To describe a few companies specifically, … Kemmx is centered here in Tulsa, and its objective is to bring to market a topical analgesic for rheumatoid arthritis. PharmSci Consulting has hired a couple of our graduates for work in Tulsa …

5 Questions with Diana SpencerBy ROBERT EVATT Tulsa World Staff Writer on Dec 9, 2011

42

Better Models. Better Results™

Developing Successful Community College – Industry Partnerships

4-22-13

Better Models. Better Results™

A Leader in Genetic Modification for Drug Discovery

Animal ModelsCell LinesLife Sciences Research ReagentsHuman Therapeutics

• DNA Modification Technology

– piggyBac TM for nearly all commercial applications

– XTNTM site-specific nuclease technology

• Stem Cell Technology

– induced Pluripotent Stem Cells (iPS)

– Spermatogonial stem cells (SSCs) and media

Transposagen Technology

Custom Services Overview• Gene editing with XTNTMs, HR vector, piggyBac Transposon

– Site-specific knockout, knock-in, edit and correction of any gene in any genome

• Animal models– Rat and mouse model generation available, additional species

possible

Internships and Hires

Future Projects

• Life Sciences Collaborative Educational Learning Laboratory (LIFE-CELL)– Train up to 50-60 scientists per year– Incubate up to 7 life science companies– CRO function