antibiotic in daily life

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  • 8/13/2019 Antibiotic in Daily Life

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    !"#$%'( %" *+%,- .%/01+"+" 1+2-+34+"005 146*

    !"#7%'8&$%+,

    9+'308%+

    :%8;(

    +8+(%#'

    !"#$%'(

    ! '&7>&;"? &8 (;$(3+"'0 34+3 @%,,( &8 (,&F(

    ?&F" A%"4%$%3(B 340 =8&F34 &/ $+'308%+

    The first antibiotic in the world

    Penicillin

    9+(%' 9+'308%&,&=-

    8&?;'0( $- '0,,;,+8 ?%E%?%"= A$%"+8- H((%&"B

    I& (0J;+, 80>8&?;'#&"

    9+'308%+, K8&F34

    9%"+8-

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    9+'308%+, N0,,

    - protect the cell

    - genetic material

    - cell movement- contains organelles

    - controls permeability

    N0,, O+,, N4+8+'308%(#'(

    K8+7 1&(%#E0

    K8+7 I0=+#E0Lipid

    Carbohydrate

    K8+7 (3+%"%"= P

    7034&? /&8 ?%Q080"#+#"=

    $+'308%+ $+(0? &" >8&>083- &/

    '+,, F+,,( F4%'4 +80 +$,0 3&

    $0 (3+%"0? $- ?%Q080"3 '&,&8

    N,%"%'+, 9+'308%&,&=-

    K8+7 1&(%#E0 N&''% K8+7 1&(%#E0 9+'%,,% K8+7 I0=+#E0 N&''% K8+7 I0=+#E0 9+'%,,% !"+08&$0( M>%8&'4030( R-'&$+'308%+

    K8+7 1&(%#E0 N&''%

    !"#$%&'()())*+ !"-.$"()())*+

    !"#$%&'()())*+ #*-.*+

    - Skin infection- Pus ,wound

    !"-.$"()())*+ $/.*0(/1#.

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    K8+7 1&(%#E0 9+'%,,%

    2'(+"-131*0 4#)1''*+ 2(-&/.5#)".-1*0 61+".-1# 7)8/(0&).+ 9()#-31#

    2'(+"-131*0 "."#/1

    - Tetanus

    2'(+"-131*0 $.-:-1/;./+

    - Gas gangrene

    K8+7 I0=+#E0 N&''%

    9.1++.-1# ;(/(--%.#

    - Gonorrhea

    K8+7 I0=+#E0 9+'%,,%

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    !"#$%' "+70

    S" =0"08+,5 ?8;= A+,(& /&8 +"#$%'B 4+( +3 ,0+(3 T "+70(

    N407%'+, "+70 P AUM5VG5WGBCWCXXAUGBCUC+7%"&CUCAYC

    4-?8&J->40"-,B+'03-,Z+7%"&ZCT5TC

    %7034-,C[C&J&CYC34%+C\C

    +]+$%'-',&XT6U6^Z40>3+"0CUC

    '+8$&J-,%' +'%?

    N&77&" "+70 P !7&J%'%,,%"

    _8+?0 "+70 P !7&J%,5 _8%7&J5 R&J+3+=

    N,+((%H'+#&" &/ !"#$%'(

    N407%'+, M38;'3;80 M>0'38;7 &/ !'#E%3- R0'4+"%(7 &/ !'#&"

    !"#$%' !'#E%3-

    Bacteriostatic- just inhibits or

    slows down of

    bacterial growth

    - Host immunity willbe able to get rid

    of the bacteria then

    Bacteriacidal- Kill the bacteria

    Depends on spectrum of Activity

    S"?%'+#&"( /&8 !"#$%' _80+370"3

    \6 9+'308%&(3+#' %" '&7$%"+#&" F%34 $+'308%&(3+#'M-"08=%(#' 0Q0'3( &8 "&"0

    U6 9+'308%'%?+, %" '&7$%"+#&" F%34 $+'308%'%?+,M-"08=%(#' 0Q0'3(

    T6 9+'308%'%?+, %" '&7$%"+#&" F%34 $+'308%&(3+#'5&8 E%'0 E08(+!"3+=&"%(#' 0Q0'3(

    Depends on spectrum of Activity

    !"#$%' !'#E%3-

    1. Narrow spectrum : Active to few species of bacteria

    (some Gram positive cocci / or

    some Gram negative bacilli)

    2. Intermediate spectrum

    : Active to several species of bacteria

    both Gram positive and Gram negative ,

    but not to other microbial

    3. Broad spectrum : Active to several species of bacteria and

    also other microbial including virus, fungi

    and parasite

    Depends on spectrum of Activity

    \6 S"4%$%#&" &/ N0,, O+,, M-"340(%(U6 S"4%$%#&" &/ N0,, R07$8+"0

    M-"340(%(

    T6 S"4%$%#&" &/ 18&30%" M-"340(%(Y6 S"4%$%#&" &/ *I! M-"340(%(

    V6 S"4%$%#&" &/ R03+$&,%' 1+34F+-

    *0>0"?( &" 70'4+"%(7

    &/ !'#&"

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    \6 N0,, O+,, S"4%$%3&8(

    !,, $+'308%+ A0J'0>3 A&)($'#+0#B '&"3+%" '0,, F+,,

    \6 N0,, O+,, S"4%$%3&8(

    M+/0 3& 4;7+" A4;7+" '0,,( ?& "&3 4+E0 '0,, F+,,B N0,, F+,, %"4%$%3&8( %"4%$%3 340 '0,, F+,, (-"340(%( >8&'0((

    LJP 10"%'%,,%"

    Without cell wall, bacteria are no longo live

    Bactericidal

    Bacterial cell lysis

    \6 N0,, O+,, S"4%$%3&8(

    Beta-lactam groupPenicillin CephalosporinMonobactamCarbapenem

    S"4%$%3&8( &/ N0,, O+,, M-"340(%(

    \6 N0,, O+,, S"4%$%3&8(

    Common use in penicillin group Amoxicillin+clavulanic

    Ampicillin Cloxacillin Penicillin

    `%=4 (>0'38;7

    .&F (>0'38;7

    \6 N0,, O+,, S"4%$%3&8(

    Allergy :Rash:Nausea:Diarrhea:Shock

    Common possible side effects

    - Person with allergic status should avoid this group of drug

    - Penicillin is so allergenic !!

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    U6 N0,, R07$8+"0 S"4%$%3&8( N0,, 707$8+"0 '&"38&, '0,,;,+8 >0870+$%,%3-

    A(0,0'3 +"? '&"38&, (;$(3+"'0 3& =& 348&;=4 340 '0,,(B

    U6 N0,, R07$8+"0 S"4%$%3&8(

    LQ0'3 4;7+" '0,,( A4;7+" '0,,( +,(& 4+E0 '0,, 707$8+"0B N0,, 707$8+"0 %"4%$%3&8( 8;>3;80 $+'308%+, '0,,

    707$8+"0 9+'308%+, '0,,( ,&(( >0870+$%,%3- '&"38&, +"? "& ,&"=08 ,%E0

    Bactericidal

    Bacterial cell lysis

    LJP 1&,-7-J%" =8&;>

    T6 18&30%" M-"340(%( S"4%$%3&8(

    S" $+'308%+, '0,,(5 >8&30%"( +80 (-"340(%]0? $-&8=+"0,,0 "+70? 8%$&(&70

    T6 18&30%" M-"340(%( S"4%$%3&8(

    18&30%"( +'3 +( (;$(38+30 +"? 0"]-70 %" $+'308%+,703+$&,%(7

    S7>&83+"3 /&8 $+'308%+, =8&F345 '0,,;,+8 80>+%8 S/ >8&30%" (-"340(%( %( %"4%$%30?5 "& ,&"=08 >8&30%" >8&?;'0?

    Bacteriostatic

    Bacterial growth stops!!

    T6 18&30%" M-"340(%( S"4%$%3&8(

    LJP

    _038+'-',%"0 N4,&8+7>40"%'&, !7%"&=,-'&(%?0 R+'8&,%?0 .%"'&(+7%?0

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    T6 18&30%" M-"340(%( S"4%$%3&8(

    _038+'-',%"0 =8&;>( 98&+? (>0'38;7aa _&"(%,,%#( b +'"0 b ?%+8840+b 7+,+8%+c6 _&J%' 3& ,%E08 +"? @%?"0- N+;(0 $&"0 7+,/&87+#&" +"? -0,,&F 30034 *& "&3 ;(0 F%34 '4%,?80" ;"?08 \U -8( +"? 340 >80="+"'%0(

    T6 18&30%" M-"340(%( S"4%$%3&8(

    N4,&8+7>40"%'&, =8&;>( 98&+? (>0'38;7 d(0? ;"?08 (38%'3,- '&"38&, _->4&%? /0E08 +"? 0"'0>4+,%#( N+;(0 +>,+(#' +"07%+

    Y6 *I! M-"340(%( S"4%$%3&8( e;%"&,&"0( %"4%$%3 $+'308%+, *I! /8&7 ;"F%"?%"=

    +"? ?;>,%'+#"=

    LJP I&8f&J+'%"

    Bacteriostatic

    V6 R03+$&,%' 1+34F+- S"4%$%3&8(

    R03+$&,%(7 %( %7>&83+"3 %" ,%E%"= &8=+"%(7 M;,/&"+7%?0 =8&;>( %"4%$%3 $+'308%+, 703+$&,%' >+34F+-

    Bacteriostatic

    Bacterial growth stops!!

    V6 R03+$&,%' 1+34F+- S"4%$%3&8(

    LJP M;,/&"+7%?0( \6 S"4%$%#&" &/ N0,, O+,, M-"340(%(U6 S"4%$%#&" &/ N0,, R07$8+"0

    M-"340(%(

    T6 S"4%$%#&" &/ 18&30%" M-"340(%(Y6 S"4%$%#&" &/ *I! M-"340(%(

    V6 S"4%$%#&" &/ R03+$&,%' 1+34F+-

    *0>0"?( &" 70'4+"%(7

    &/ !'#&"

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    G&;30 &/ !?7%"%(38+#&"

    g8+, 8&;30 S"38+E+(';,+8 AS:B 8&;30G&;30 &/ !?7%"%(38+#&"

    _&>%'+, 8&;30

    S"?%'+#&" &/ !"#$%' !?7%"%(38+#&"

    90/&80 70+, P T^ 7%" h \ 483&7 +,F+-( 7%(;"?08(3&&? +( $+'308%+, %"/0'#&"

    R&;34 ;,'08

    l&%"3 (F&,,0" /8&7 >4-(%&,&=%'+, +m+'@

    +m08"(

    kS" &8?08 3& (0,0'3 340 8%=43 +"#$%' 3& 340 &8=+"%(7(F%34 ,0(( '4+"'0 &/ +"#$%' 80(%(3+"'0 ?0E0,&>70"3

    T6 !"#$%' (4&;,? $0 ;(0? /&,,&F%"= 340 8;,0 &/ 34;7$

    kS"%#+, (3+=0 &/ %"/0'#&" P "+88&F (>0'38;7 H8(3

    kN48&"%' %"/0'#&" P $8&+? (>0'38;7

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    18&>08 d(0 &/ !"#$%'(

    Y6 108%&? &/ 380+370"3 ?0>0"?( &" $+'308%+, '4+8+'308(

    CS" =0"08+,5 340 (;%3+$,0 >08%&? %( VC[ ?+-(

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    180="+"'- (4&;,? +E&%? 3038+'-,'%"0

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    F+(30 340 7&"0-

    [6 90 '&"(%?080? /&8 >+#0"3p( $+'@=8&;"?S"',;?0P +,,08=%' (3+3;( $+'@=8&;"? ?%(0+(0

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    \6 !"#$%' 80(%(3+"'0

    U6 g>>&83;"%(#' %"/0'#&"

    0JP 2#/313#

    RR

    R

    antibiotic

    g;3'&70( /8&7 +"#$%' 7%(;(0

    T6 *8;= +,,08=-

    0JP 10"%'%,,%"

    Y6 _&J%' +"? (%?0 0Q0'3

    N4,&8+7>40"%'&, P +"07%+

    L8-348&7-'%" P 3&J%' 3& ,%E08

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    V6 :%3+7%" ?0H'%0"'-

    0JP :%3 9 b :%3 q

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    d>>08 G0(>%8+3&8- _8+'3 S"/0'#&"

    _&"(%,,%#( P N&77&" >+34&=0" P K8+7 >&(%#E0 '&''% 10"%'%,,%"5 !7&J%'%,,%"

    :%8+, %"/0'#&" 9+'308%+, %"/0'#&"

    >;(

    .&F08 G0(>%8+3&8- _8+'3 S"/0'#&"

    1"0;7&"%+ P N&77&" >+34&=0" P K8+7 >&(%#E0 '&''%

    K8+7 "0=+#E0 $+'%,,%

    10"%'%,,%"5 !7&J%'%,,%"

    K+(38&%"30(#"+, _8+'3 S"/0'#&"

    *%+8840+ P N&77&" >+34&=0" P K8+7 "0=+#E0 $+'%,,% e;%"&,&"05 _038+'-',%"0

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    N-(##( P N&77&" >+34&=0" P K8+7 "0=+#E0 $+'%,,%

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    N&77&" >+34&=0" P K8+7 >&(%#E0 '&''% 1&,-7-J%" A&%,70"3B

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    M->4%,%( P N&77&" >+34&=0" P M>%8&'4030 10"%'%,,%" A%"j0'#&"B