ieQ: ESTABLISHMENT OF AUSTRALIA’S

FIRST INFECTIVE ENDOCARDITIS

REGISTRY AND BIO.BANK.

Enquiries: Dr Robert Horvath MBBS FRACP FRCPA

Infectious Diseases Physician and Clinical Microbiologist

Infection Management Services; The Prince Charles Hospital

Department of Health | Queensland Government

Rode Rd. Chermside 4032 t. 07 [31394111]

e. robert.horvath@health.qld.gov.au | www.health.qld.gov.au

Registry & Surveillance

ASID May 2018

The Prince

Charles Hospital

Robert Horvath1,2,4,5, John F Sedgwick1,4,5, Yong S Wee1,4,5, Joseph C Lee3,4,5, David B Godbolt2,5 and Anne Cameron1,4,5 on behalf of the ieQ Collaborative.

1. Internal Medicine, The Prince Charles Hospital, Brisbane, Queensland, Australia; 2. Pathology Queensland, Brisbane, Australia 3. Medical Imaging Department, The Prince

Charles Hospital, Brisbane, Queensland, Australia; 4. Faculty of Medicine, The University of Queensland, Australia 5. infective endocarditis Queensland [ieQ], The Prince

Charles Hospital, Queensland, Australia. Funded by the Metro North Hospital and Health Service SEED Innovation Program 2016/17

Acknowledgements: This initiative would not be possible without the support of a great number of

people who have generously given of their time, experience and support. We

sincerely thank [in no particular order]: Claire Harrison and the MNHHS SEED

Innovation Program, Mary Lazo and Jon Fraser [Metro North IT], TPCH Infection

Management Services, Glen Lawrence and Christine Crowley [TPCH Pathology],

the TPCH Ethics Team and Committee, Brooke Chadwick [IMS Business

Manager], Rhonda Mead [Nursing Director, IMS], Elizabeth Clark [Pathology

Queensland] and most importantly, our patients. Thank you.

Introduction

Infective Endocarditis Queensland [ieQ], founded in 2017 and based at The Prince

Charles Hospital [TPCH], is a multidisciplinary collaborative of health professionals

and academics established to support research, clinical care and outcomes of people

with infective endocarditis.

Methods

ieQ has conceived a Bio.Bank for long-term storage of blood, tissue and microbes

referenced to a Registry of patient demographics, outcomes, treatment and discipline-

specific data of interest e.g. echocardiography, antibiotic therapy and health service

utilisation. Establishment of the initiative was facilitated by a grant from the

Queensland Health Metro North SEED Innovation Fund.

The Registry and Bio.bank have received institutional ethics approval, with patients to

be offered inclusion via informed consent.

A core feature of the Registry is its design that was developed in partnership with

Queensland Health Metro North Information Technology, and which is a live and on-

line database. This database includes clinical, pathology and imaging features, and is

enabled to collate data from affiliated platforms [admission data] in addition to direct

data entry. The long term future forecast is for the database to ‘link’ with additional data

cohorts.

Results

The first 12 months have seen the consolidation of an ethical framework; development

of a collaborative structure and key administration guidelines; purchase, installation

and custodianship of Bio.bank freezer within Pathology Queensland auspices; and the

development and deployment of the Registry platform.

The collaborative is positioned to commence patient recruitment in mid 2018.

Secondary outcomes to date:

▪ Supported collaborative and interdisciplinary engagement with regular IE Working

Group meetings, inclusive of all of Metro North HHS, public and private pathology

services, and academic institutions.

▪ Formulation of multi-disciplinary Endocarditis Advisory Team “EAT”, initially TPCH-

centric with a long-term aim to provide support statewide.

▪ [In development] A University of Queensland sponsored Website with patient and

practitioner information and a portal for national and international links.

▪ Supported collaboration and translation of research outcomes:

International Symposium on Modern Concepts in Endocarditis and

Cardiovascular Infections; June 22-24 [Dublin]. 6 abstracts accepted posters

Cardiac Society of Australia and New Zealand; Aug 2017 [Perth]. 1 abstract.

The Prince Charles Symposium; Oct 2017. 2 abstracts accepted

Infectious Diseases Society of America; Oct 2017 [San Diego]. 1 abstract

accepted

Cardiac Society of Australia and New Zealand; August 2018 [Brisbane];

abstract in review

Disclosure of Interest Statement: ieQ is funded by in-kind support of Queensland

Health and a grant from the Queensland Health Metro North SEED Innovation Fund.

No pharmaceutical grants were received in the development of this study.

ieQ Management

Committee

Research Translation Education

and

capacity

building

Patient

support Clinical

advisory

group

ieQ Expert

Working Group

▪ Registry

and

Bio.bank

▪ “EAT”

TPCH

Expert

advisory

Team

▪ Information

sheets

▪ Videos

▪ Website

▪ Conferences

▪ Publications

▪ Grand

rounds

▪ Networking

eg Primary

Health

▪ Advanced

trainees

▪ Statewide

support

▪ S.lugdunensis

▪ Q fever

▪ HACEK

▪ Candida

▪ Other

Collaborative

framework:

state, national and

international

ieQ

Collaborative

structure Administration

Patient/Consumer

representative

Conclusion

A quality Infective Endocarditis Registry and Bio.bank is a pre-requisite for the

clinically-critical work of improving diagnosis, management and patient outcomes of

individuals affected by Infective Endocarditis.

Under a clinical and research framework, ieQ aims to improve understanding,

in an Australian context, of this disease.