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Molecular Diagnostics Advancing the fundamentals… Non-clinical Broad spectrum… BioRadar Preemptive surveilance… Drug Discovery Equipping the benchtop… Personalized Medicine Decoding the DNA…

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Page 1: B I O  Booth  Pres For Website  S D7  S L I D E S  O N L Y

Molecular DiagnosticsAdvancing the fundamentals…

Non-clinicalBroad spectrum…

BioRadarPreemptive surveilance…

Drug DiscoveryEquipping the benchtop…

Personalized MedicineDecoding the DNA…

Page 2: B I O  Booth  Pres For Website  S D7  S L I D E S  O N L Y

Founded in Hong Kong in 1999, Hai Kang Life Corporation Limited (HKLife) has grown into a leading research-based biotech company

Strategically positioned with research centers in Hong Kong and Beijing, utilizing a business model of best practices from East and West

Page 3: B I O  Booth  Pres For Website  S D7  S L I D E S  O N L Y

Operating through a portfolio of wholly-owned subsidiaries, existing platforms are focused on the provision of advanced diagnostic tools

Serving the world with biotechnology, ensuring the health and safety of society

Page 4: B I O  Booth  Pres For Website  S D7  S L I D E S  O N L Y

Clinical Testing

Veterinary

Food Safety

Products & Services

Page 5: B I O  Booth  Pres For Website  S D7  S L I D E S  O N L Y

Global patent portfolio: LOAC, Bird Flu, Foot & Mouth, GMO…

HKLife is a leading member of the Chinese National Task Force for preventing and monitoring outbreaks

Published in Nature Biotechnology, Science, NEJM and Lancet

SARS detection kits were launched in rapid response to the Asian epidemic (2003) Enhanced RT-PCR was developed, it is a 100x more sensitive than standard RT-PCR

Page 6: B I O  Booth  Pres For Website  S D7  S L I D E S  O N L Y

In 2000, developed the world’s first AIV (H5N1) detection kit, leveraging highly advanced NASBA technology and later, releasing novel optical methods

Point-of-care field training has been conducted in the Asia Pacific and Middle East

In 2005 this system became the first to be approved by the Japan Ministry of Agriculture, Forestry and Fisheries

Fighting influenza has earned HKLife international recognition

Page 7: B I O  Booth  Pres For Website  S D7  S L I D E S  O N L Y

Introducing MOBILE FIELD UNIT for point-of-care deployment, utilizing NASBA and novel optical methods

LATEST: A/H1N1 test kit now available

Comparable sensitivity to conventional PCR

Self-contained, portable and user friendly

Heating block, centrifuge, UV lamp, reagents and pipettes

Page 8: B I O  Booth  Pres For Website  S D7  S L I D E S  O N L Y

Molecular diagnostics is constantly making advances but the journey to a product platform remains fragmented…

…the amalgamation of miniaturized lab-on-a-chip technology with DNA microarrays provides the perfect opportunity

Page 9: B I O  Booth  Pres For Website  S D7  S L I D E S  O N L Y

Electric Field Assisted Diagnostic chip HKLife is delivering a practical solution with the revolutionizing

EFADchip

Page 10: B I O  Booth  Pres For Website  S D7  S L I D E S  O N L Y

EFADchip System

Page 11: B I O  Booth  Pres For Website  S D7  S L I D E S  O N L Y

EFADchip System

A matrix of biological reactions on a single chip allows for selective detection of multiple pathogens from the same sample

Fully automated: reaction, detection and data analysis

Low cost detector & chips

Requires only small volumes of reagents and analytes

Page 12: B I O  Booth  Pres For Website  S D7  S L I D E S  O N L Y

Novel technology drives migration of DNA to reactive sites• Rapid hybridization within minutes• No undesirable electrochemical reactions and instabilities

Signal detection does not require fluorescence• No tagging of samples is necessary• Using colloidal nanogold for detection in any environment

Simple and reliable platform technology• Scaleable with established materials and processes• Modest setup cost and inexpensive re-useable chip cartridge

Page 13: B I O  Booth  Pres For Website  S D7  S L I D E S  O N L Y

EFADchipPlatform Applications

BioRadar• Pre-emptive surveillance• Efficient containment• Traveler security

Marker detection

Screen for tumor markers e.g. BRCA1 (breast cancer and ovarian cancer

Environmentalmonitoring

• E. Coli in food and drinking water

• Legionella in air conditioning cooling systems

Food Testing• Genetically Modified

Organisms

• Bacterial & viral contaminations

Veterinary diagnosis• Foot-and-mouth disease

• Avian influenza

• Newcastle disease

Infectious diseases• Detect viral or bacterial

infection (Hepatitis, HIV, HPV, Anthrax, Influenza…)

• Screening donated blood

Page 14: B I O  Booth  Pres For Website  S D7  S L I D E S  O N L Y

EFADchipPlatform Applications

EFADchip

Programmable for specific market applications including the full spectrum of molecular diagnostics,

drug discovery, bio-security and forensics

The journey…

Precursor to a bio-radar surveillance system for early-warning and responsive containment, encompassing all current and emerging pathogens

Opening the door to Personalized Medicine &Companion Diagnostics

Page 15: B I O  Booth  Pres For Website  S D7  S L I D E S  O N L Y

The journey…

“…revolutionizing the practice of clinical diagnostics, providing effective platforms for point-of-care applications focused on personalized medicine”

Hai Kang Life Mission Statement

Page 16: B I O  Booth  Pres For Website  S D7  S L I D E S  O N L Y

HKLife continues to work closely with pharmaceutical companies, hospitals, clinics and patients around the world to deliver the highest quality molecular diagnostic products and services across the board, from pharma to family…

Page 17: B I O  Booth  Pres For Website  S D7  S L I D E S  O N L Y

Hai Kang Life welcomes you on the journey…