balanced ecosystem is our key to sustenance - advinus a pioneer in agrochemical development ... and...
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At Advinus, we believe in adding continuous value to a more greener & healthier environment through responsible & quality agro R&D, Product Life Cycle Management and global registrations. Being a pioneer in agrochemical development for 25 years in India, has helped us gain valuable insight & immense experience to be your reliable partner for complete Agro Lifecycle Management Solutions.
Why partner with Advinus?• Management and scientific leadership team with extensive international experience
• Leading center for regulatory toxicology with the largest animal vivarium in South Asia
and one of Asia’s largest REACH testing facilities
• Experience of over 5,500 successful regulatory GLP submissions and over 1,000 Phys
chem studies
• More than 17 successful audits by global and regional regulatory agencies
• Data generated at Advinus successfully accepted by EPA and OECD countries
• State-of-the-art Pilot plant dedicated to Process Development and Process Validation of
Active Ingredients
Accreditations & Guidelines: • GLP, OECD, US-EPA, CIPAC, EEC, FAO
• NGCMA India
• W&V Netherlands
• Atomic Energy Regulatory Body, Government of India
• BfR Germany
• AAALAC
Infrastructure:• 220,000 Sq ft
People: • 450+
Advinus Agrochemical Development Services
Process Chemistry
• 5-Batch Synthesis
• Custom synthesis of intermediates, exotic raw materials, impurities/metabolites
• Route scouting & identification for generic AI’s
• Process Development and Optimization of Novel and/or Non-infringing routes
• Complete process analytical package including impurity profiling
• Process Scale up
• Asymmetric synthesis, chiral separations
• Technology transfer services
• Patent technical specification preparation and filing of patents wherever applicable
Analytical Chemistry Capabilities
• Structural characterization
• Impurity profiling
• Analytical method development and validation
• Preparation of reference and working standards
Genetic Toxicology
• Bacterial Mutation Assay
• invitro mouse lymphoma
• invitro cytogenetic assay
• invivo erythrocyte micronucleus assay
• invivo bone marrow metaphase assay
• Preparation of reference and working standards
General Toxicology Rodents
• Single-doset acute (including oral, dermal, inhalation, irritation and sensitization tests)
• Repeated dose sub-acute and sub-chronic studies
• Chronic toxicology studies
• Carcinogenicity studies
Full range of reproductive and developmental toxicity studies required for product registration• ReproductivetoxicologyscreeningtoOECD
421and422
• Developmental toxicology in rats and rabbits
• Multigenerational studies in rats
• Avian Reproduction studies
Non-Rodent Toxicology
• Single dose studies
• Dose escalation study maximum tolerated dose
• Repeated dose
• Chronic toxicology
ADME Studies• Studies in rodents including mass balance,
tissue distribution in cold and radiolabelled compound and metabolite identification
Analytical Capabilities
• Method development/ validation for active ingredients in different substrates
• Sample analysis for Eco-Toxicology, Air- Inhalation and Toxicology studies
• ADME support
Residue Analytical • Physical & Chemical properties for Technical
AI and Agro-formulations
• Method Development & Validation
• Residue & Persistence in Soil, Water & Plants (as per GAP & GLP or Non GLP)
5 Batch Analysis
• Technical material analysis for AI and impurities ≥0.1%
Physico-chemical studies• Melting/freezing point
• Boiling point
• Relative density
• Surface tension
• Water solubility
• Partition co-efficient n-octanol/water
• Flash-point
• Flammability
• Oxidising properties
• Stability in organic solvents and identity of relevant degradation products
• Dissociation constant
• Viscosity
• Photolysis studies
• Explosive properties
• Auto ignition
• Self ignition
E-fate Studies
• Hydrolysis as a function of pH
• Aqueous Photolysis
• Adsorption Co-efficient by HPLC
• Adsorption/Desorption in Soil by Batch Equilibrium
• Radiolabelled studies
• Persistence Studies (Field & Lab)
• Residue Studies
• Biodegradation
• Ecotox studies in fish, daphnia, algae and honeybees
Other Services
• Authentication of Test Item and Issuing COA
Agro Formulation
• Formulation recipe development of conventional and new generation formulations
• Improvement of existing formulations
• Development of combination formulations
• Selection and recommendation of the right type of formulation for development
• Stability studies accelerated and multi-locational storage
• Supply of samples for field trials and for toxicological studies
• Pilot plant scale up studies and process optimization
• Technology transfer for commercial production
Field Trial Support
• Plant analysis for the nutrients
• Soil analysis – physical & chemical properties
• Water analysis on post field trials
• Fertilizer analysis for major & micro nutrients
Advinus Agrochemical Development Services
Process Chemistry:
• 40,000sq.ft.labwithfacilitiesforCryo{(-)1000C},hightemp{(+)2200C},Highpressure&Hydrogenationreactions
• 10Reactors–20LAGR,200LSSRwithcapacitiesof20Lto650L
• Dedicatedinfrastructureforradiolabeledcompounds
• Teamincludes56scientists(14PhDs,37Masters)
Safety Assessment:
• Over70,000sqft.lab
• Speciesavailable:Rats,Mice,Guineapigs,Rabbits,Chicken,Pigeons,Quail,Freshwaterfish,Algae,Daphnia,&Honeybees
• Teamincludesaround108scientists(10PhDs,8DABTs)
Analytical R&D:
• Labarea:approx.4000sq.ft.withseparatefacilityforradiotracerstudies
• Teamincludes25Researchscientists(2PhDsand20Masters)
• EquipmentsincludeLC-MS/MS(API2000,API4000),GC-MS,HPLC-UV/PDA/-RAM,andGC-ECD/NPD/FID,SuntestApparatusandinstrumentsforPhys-Chemstudies
Agro-Formulations:
• 2000sqftofdedicatedlaboratorywithnecessaryequipmentslikeribbonblenders,airjetmills,dynomills,extruder,homogenizerandspraygranulator
• 500sq.ftofdedicatedpilotplantsforscale-upexperiments
• Full-fledgedanalyticallaboratorieswithGCs,HPLCs,viscometer,KFtitrators,UV-VISspectrophotometers
Advinus Infrastructure