basic disease processes etiology (cause ex.mycobact. tuberc.) clinical features (signs and symptoms)...
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Basic Disease ProcessesBasic Disease Processes
Etiology Etiology (Cause ex.mycobact. Tuberc.)(Cause ex.mycobact. Tuberc.)
Clinical Features Clinical Features ((Signs and SymptomsSigns and Symptoms))Fever, cough, sputum, abnormal xrayFever, cough, sputum, abnormal xray
PathogenesisPathogenesis`̀
))Mechanisms:inflammationMechanisms:inflammation((
SignsSigns of Disesaseof Disesase
Measurable / ObservableMeasurable / Observable
Examples: Fever, Bleeding, Examples: Fever, Bleeding, “Lesions“Lesions””
““LesionsLesions””Clinical Area of Abnormality Associated Clinical Area of Abnormality Associated
with Disease / Disease Processwith Disease / Disease Process
SymptomsSymptoms of Diseaseof Disease
SubjectiveSubjective
Example: Pain, ParesthesiaExample: Pain, Paresthesia
Basic Disease ProcessesBasic Disease ProcessesPathogenetic MechanismsPathogenetic Mechanisms
- M I N D- M I N D- - M M etabolic - etabolic - Hormonal; NutritionalHormonal; Nutritional
Example: Diabetes MellitusExample: Diabetes Mellitus
I I nflammatory - nflammatory - Infection, ImmunologicInfection, ImmunologicExamples: Tuberculosis, PemphigusExamples: Tuberculosis, Pemphigus
N N eoplastic - eoplastic - Any Neoplasm, Benign or MalignantAny Neoplasm, Benign or MalignantExamples: Papilloma, Squamous Cell CarcinomaExamples: Papilloma, Squamous Cell Carcinoma
D D evelopmental - evelopmental - Genetic or Acquired MalformationGenetic or Acquired Malformation
Example: Mandibular TorusExample: Mandibular Torus
Evaluation and Characterization of Evaluation and Characterization of Soft Tissue Soft Tissue “Lesions“Lesions””
11.. TypeType of “Lesion of “Lesion””
22.. ColorColor of “Lesion” of “Lesion” (Be Specific)(Be Specific)
33.. Surface CharacteristicsSurface Characteristics of “Lesion of “Lesion””
44.. Palpable FeaturesPalpable Features of “Lesions of “Lesions””
55.. AttachmentAttachment of “Lesions of “Lesions””ALSO NOTEALSO NOTE::
11.. Size (in mm. or cm. or compared to known object - Size (in mm. or cm. or compared to known object - “dime-sized” or “dime-sized” or “grape sized”)“grape sized”)
22.. Specific Location of Lesion Specific Location of Lesion (Using Oral Togography)(Using Oral Togography)
33.. Number of lesions (if more than one)Number of lesions (if more than one)ANDAND::
11 . .History : Duration and Changes and Rate of ChangesHistory : Duration and Changes and Rate of Changes
22 . .Symptoms: Asymptomatic (ASX), Pain, TendernessSymptoms: Asymptomatic (ASX), Pain, Tenderness
TypesTypes of “Lesions of “Lesions””FLAT LESIONSFLAT LESIONS
MaculeMacule
PlaquePlaque
UlcerUlcerSwellings (Solid Tissue)Swellings (Solid Tissue)
PapulePapule
NoduleNodule
TumorTumorSwellings (Fluid-Filled)Swellings (Fluid-Filled)
VesicleVesicle
BullaBulla
Pustule/AbscessPustule/Abscess
CystCystCombinations of TypesCombinations of Types
plaque
nodule
cyst
FLAT FLAT LESIONSLESIONS
MaculeMacule
PlaquePlaque
UlcerUlcer
TYPE - TYPE - MaculeMaculeA flat lesion - color change A flat lesion - color change ONLY - ONLY - Not paplable at allNot paplable at all!! !!
When examining Indicate When examining Indicate Specific ColorSpecific Color
This This maculemacule is an is an Amalgam Tattoo Amalgam Tattoo
Description: A Single 8x10 mm. Bluish-Grey pigmented maculeof the left mandibular buccal edentulous alveolar ridge mucosa (missing #19 area)
8 mm.
10 mm.
TYPE - TYPE - PlaquePlaqueA flat and slightly raised lesion: palpableA flat and slightly raised lesion: palpable
Some may be Wiped OffSome may be Wiped Off
Usually whiteUsually white
Often a thickening of the keratin surfaceOften a thickening of the keratin surface
ThisThis plaque plaque is a “pre-cancerous” is a “pre-cancerous” epithelial epithelial dysplasiadysplasia
Description: A single 8x12 mm. irregular shaped rough surfaced leukoplakia (non-wipable white plaque) of the right lateral tongue.
TYPE - TYPE - UlcerUlcerLocalized area of Localized area of complete loss of surface epitheliumcomplete loss of surface epithelium
Crusted/Scabbed on skin - Pseudomembrane intraorallyCrusted/Scabbed on skin - Pseudomembrane intraorally
Often PainfulOften Painful
May be result of trauma, infection, cancer or other diseaseMay be result of trauma, infection, cancer or other diseaseThese two These two ulcersulcers are are “Canker Sores / Aphthous Ulcers“Canker Sores / Aphthous Ulcers””
Pseudomembrane overlyingPseudomembrane overlyingExposed Connective TissueExposed Connective Tissue
TYPE - TYPE - Ulcer / Other ExamplesUlcer / Other Examples
Both of these lesions areBoth of these lesions areSquamous Cell CarcinomasSquamous Cell Carcinomas
SWELLINGS SWELLINGS (Solid Tissue)(Solid Tissue)Categorized by SizeCategorized by Size
PapulePapule~~1-21-2 mmmm
NoduleNodule < <11 cmcm
TumorTumor > >11 cmcm
Papule Papule (Solid Tissue Swelling)(Solid Tissue Swelling)
Small (1-2 mm) Swelling of Solid TissueSmall (1-2 mm) Swelling of Solid Tissue
These These PapulesPapules are are Fordyce GranulesFordyce Granules (Ectopic Sebaceous Glands)(Ectopic Sebaceous Glands)
Nodule Nodule (Solid Tissue Swelling)(Solid Tissue Swelling)““Larger” ( up to 1 cm.) Swelling of Solid TissueLarger” ( up to 1 cm.) Swelling of Solid Tissue
May be Hyperplasia, benign of malignant neoplasmMay be Hyperplasia, benign of malignant neoplasm
This This NoduleNodule is Hyperplasia - is Hyperplasia - “Pyogenic Granuloma“Pyogenic Granuloma””
Tumor Tumor (Solid Tissue Swelling)(Solid Tissue Swelling)
Larger still (< 1 cm) Swelling of Solid TissueLarger still (< 1 cm) Swelling of Solid Tissue
May be Hyperplasia or Neoplasm of Epithelium or of May be Hyperplasia or Neoplasm of Epithelium or of Connective TissueConnective Tissue
This This TumorTumor is a Benign Neoplasm of Accessory is a Benign Neoplasm of Accessory Salivary Gland Origin - a Salivary Gland Origin - a Pleomorphic AdenomaPleomorphic Adenoma
TYPE - Vesicle TYPE - Vesicle (Fluid Filled (Fluid Filled Swelling)Swelling)
Intraepithelial Fluid
““Small” > 2 mm. Blister Small” > 2 mm. Blister (Fluid Filled (Fluid Filled and Intraepithelial)and Intraepithelial)
Most commonly the result of viral Most commonly the result of viral (Herpes) infection or allergy(Herpes) infection or allergy
These These VesiclesVesicles are due to are due to Recurrent Recurrent Herpes simples infectionHerpes simples infection
TYPE - Bulla TYPE - Bulla (Fluid Filled Swelling)(Fluid Filled Swelling)
Intraepithelial Fluid
““Large” Blister - Large” Blister - Fluid Filled and Fluid Filled and IntraepithelialIntraepithelial
Usually Immunopathic Disease - Usually Immunopathic Disease - Pemphigus, etcPemphigus, etc..
This This BullaBulla is the result of is the result of Pemphigus Pemphigus VulgarisVulgaris
Collapsed Bulla (Ruptured and Fluid has Escaped)
Residual Ulcers
TYPE - Cyst TYPE - Cyst (Fluid Filled Swelling)(Fluid Filled Swelling)
Fluid
Epithelial Lining
Cyst
Pathologic Cavity / SpacePathologic Cavity / Space
Lined by EpitheliumLined by Epithelium
Usually Filled with FluidUsually Filled with Fluid
Swelling in soft tissue -Radiolucency in Swelling in soft tissue -Radiolucency in JawsJaws
This This CystCyst is a is a Mucous Retention CystMucous Retention Cyst
Fluid
Epithelial Lining
Surface CharacteristicsSurface Characteristics of “Lesions of “Lesions””
SmoothSmooth
Papillary / Papillary / VerrucousVerrucous
UlceratedUlcerated
Smooth
VerrucousPapillary
Ulcerated
SmoooooothSmooooooth
PapillaryPapillary
UlceratedUlceratedLoss of Area of Surface EpitheliumLoss of Area of Surface Epithelium
Ulcerated
Palpable CharacteristicsPalpable Characteristics of “Lesions of “Lesions””
CompressibleCompressibleFluctuantFluctuant
Pressure Displaces FluidPressure Displaces FluidSoft Soft (Solid Tissue)(Solid Tissue)Firm Firm (Solid Tissue)(Solid Tissue)
HardHardIndurated Indurated (Usually applies (Usually applies
to Malignancy)to Malignancy)Bony Bony (Hard as Bone)(Hard as Bone)
Fluctuant
Indurated
Fluid
AttachmentAttachment of “Lesions” of “Lesions”- Soft Tissue Masses- Soft Tissue Masses- -
AttachmentAttachmentPedunculatedPedunculated
Attached by a Attached by a Narrow StalkNarrow Stalk
SessileSessileAttached by a Attached by a Broad BaseBroad Base
PalpationPalpationMovableMovable
FixedFixed
Pedunculated
Sessile
Movable
Fixed
PedunculatedPedunculatedAttached by a Narrow StalkAttached by a Narrow Stalk
Pedunculated
SessileSessileAttached to Normal Tissue by a Broad Attached to Normal Tissue by a Broad
BaseBase
Sessile
ORAL “CANCER”ORAL “CANCER”- Any Malignant Neoplasm- Any Malignant Neoplasm
--
96%96%“ “ Carcinoma” (Epithelial)Carcinoma” (Epithelial)
91%91%“ “ Squamous Cell CarcinomaSquamous Cell Carcinoma
ORAL CANCERORAL CANCERSquamous Cell CarcinomaSquamous Cell Carcinoma
Invasive Neoplasm of Malignant Squamous Epithelium
Malignant Squamous Cells Invading Muscle
Clinical Clinical Features Features
- Oral SCCA- Oral SCCA- - Leukoplakia - White Plaque
Erythroleukoplakia - Red and White Plaque
Ulcer with Crust / Scab
Tumor with Surface Ulcer
Erythroplakia - Red Plaque
ORAL CANCERORAL CANCER“TNM”“TNM” Classification Classification and Stagingand Staging
Primary Cancer - “T”“T”
Local Metastasis - “N”“N”
(Such as Lung)
(Regional LymphNodes)
ORAL CANCERORAL CANCERPre-Malignant LesionsPre-Malignant Lesions
“Pre-malignant” = Any Lesion with Increased Potential to Become Malignant
““Premalignant” LesionsPremalignant” Lesions ” ”
LeukoplakiaLeukoplakia8080 % % HyperkeratosisHyperkeratosis
Transformation ~ 6Transformation ~ 6% % 17-1917-19 % % DysplasiaDysplasia
Increased Transformation RiskIncreased Transformation Risk))1-31-3“ % “ % Early” SCCAEarly” SCCA((
Erythroplakia/ ErythroleukoplakiaErythroplakia/ Erythroleukoplakia8080 % + % + Dysplasia Dysplasia (or SCCA)(or SCCA)
Much Greater Risk of Cancer or Much Greater Risk of Cancer or TransformationTransformation
LeukoplakiaLeukoplakia
ErythroLeukoplakiaErythroLeukoplakia
ErythroplakiaErythroplakia