be the next winner! · • ability to e-mail full-textlinks. •the latestnewsfromsciencenow. •...

9
Congratulations to Dr. Tiago Branco on winning the 2011 Eppendorf & Science Prize for his studies on how dendrites discriminate temporal input sequences and apply different integration rules depending on input location. The results of Dr. Brancos research provide insight on how the brain performs computations, and suggest that even single neurons can solve complex computational tasks. You could be the 11th winner of this award. The annual Eppendorf & Science Prize for Neurobiology honors young scientists for their outstanding contribu- tions to neurobiological research based on methods of molecular and cell biology. The winner and finalists are selected by a committee of independent scientists, chaired by Science’s Senior Editor, Dr. Peter Stern. To be eligible, you must be 35 years of age or younger. If you’re selected as this year’s winner, you will receive US$ 25,000, have your work published in Science and be invited to visit Eppendorf in Hamburg, Germany. Past winners and finalists have come from as far a field as China, Chile, India and New Zealand. Yes, it can happen to you. Enter your research now! Eppendorf & Science Prize for Neurobiology 2011 Winner Dr. Tiago Branco Postdoctoral Research Fellow University College London Be the next winner! Deadline for entries: June 15, 2012 It´s easy to apply! Learn more at: www.eppendorf.com/prize Get recognized! US$ 25,000 Prize eppendorf ® is a registered trademark of Eppendorf AG, Germany. Copyright © 2012 by Eppendorf AG. Kurstin Roe Photography

Upload: others

Post on 13-Jul-2020

0 views

Category:

Documents


0 download

TRANSCRIPT

Page 1: Be the next winner! · • Ability to e-mail full-textlinks. •The latestnewsfromScienceNOW. • Career advice articles from Science Careers. • Access to theScience weekly podcastand

Congratulations to Dr. Tiago Branco on winning the 2011 Eppendorf & Science Prize for his studies on how

dendrites discriminate temporal input sequences and apply different integration rules depending on input

location. The results of Dr. Branco’s research provide insight on how the brain performs computations, and

suggest that even single neurons can solve complex computational tasks.

You could be the 11th winner of this award.

The annual Eppendorf & Science Prize for Neurobiology honors young scientists for their outstanding contribu-

tions to neurobiological research based on methods of molecular and cell biology. The winner and finalists are

selected by a committee of independent scientists, chaired by Science’s Senior Editor, Dr. Peter Stern.

To be eligible, you must be 35 years of age or younger. If you’re selected as this year’s winner, you will receive

US$ 25,000, have your work published in Science and be invited to visit Eppendorf in Hamburg, Germany.

Past winners and finalists have come from as far a field as China, Chile, India and New Zealand.

Yes, it can happen to you. Enter your research now!

Eppendorf & Science Prizefor Neurobiology

2011 Winner

Dr. Tiago Branco

Postdoctoral

Research Fellow

University College

London

Be the

next

winner!

Deadline for entries:

June 15, 2012

It´s easy to apply! Learn more at:

www.eppendorf.com/prize

Get recognized!

US$ 25,000 Prize

ep

pen

do

rf®

isa

reg

iste

red

trad

em

ark

of

Ep

pen

do

rfA

G,

Germ

any.

Co

pyri

gh

20

12

by

Ep

pen

do

rfA

G.

Ku

rstin

Ro

eP

ho

tog

rap

hy

Page 2: Be the next winner! · • Ability to e-mail full-textlinks. •The latestnewsfromScienceNOW. • Career advice articles from Science Careers. • Access to theScience weekly podcastand

CELL SCIENCES INC � 480 NEPONSET STREET, BUILDING 12A, CANTON, MA 02021 � [email protected]

TOLL FREE: (888) 769-1246 � TEL: (781) 828-0610 � FAX: (781) 828-0542 � WEB: WWW.CELLSCIENCES.COM

ww

w.c

ellscie

nces.c

om

ww

w.c

ellscie

nces.c

om

cell sciences

®

cytokine center

®

LIST OF PROTEINS

4-1BBL

4-1BB Receptor

6 Ckine

ACAD8

ACAT2

gAcrp30/Adipolean

Activin A

ACY1

ADAT1

Adiponectin

ADRP

AITRL

Akt1

Alpha-Feto Protein (AFP)

Alpha-Galactosidase A

Angiopoietin-1 (Ang-1)

Angiopoietin-2 (Ang-2)

Angiostatin K1-3

Annexin-V

apo-SAA

Apoliprotein A-1

Apoliprotein E2

Apoliprotein E3

Apoliprotein E4

APRIL

Artemin

ATF2

Aurora A

Aurora B

BAFF

BAFF Receptor

BCA-1 / BLC / CXCL13

BCMA

BD-1

BD-2

BD-3

BDNF

Bivalirudin

BMP-2

BMP-4

BMP-7

BMP-13

sBMPR-1A

Brain Natriuretic Protein

BRAK

Breast Tumor Antigen

C5a

C5L2 Peptide

C-10

C-Reactive Protein

C-Src

Calbindin D-9K

Calbindin D-28K

Calbindin D-29K

Calmodulin

Calcitonin Acetate

Carbonic Anhydrase III

Carcino-embryonicAntigen

Cardiotrophin-1

Caspase-3

Caspase-6

CD4

CD14

CD22

CD40 Ligand / TRAP

CD95 / sFas Ligand

CD105 / Endoglin

CHIPS

CNTF

Collagen

CREB

CTACK/CCL27

CTGF

CTGFL/WISP-2

CTLA-4/Fc

CXCL16

Cytokeratin 8

DEP-1

Desmopressin

Disulfide Oxidoreductase

E-selectin

ECGF

EGF

Elafin/SKALP

EMAP-II

ENA-78

Endostatin

Enteropeptidase

Eotaxin

Eotaxin-2

Eotaxin-3 (TSC)

EPHB2

EPHB4

Eptifbatide

Erk-2

Erythropoietin (EPO)

Exodus-2

Fas Ligand

Fas Receptor

FGF-1 (acidic)

FGF-2 (basic)

FGF-4

FGF-5

FGF-6

FGF-7/ KGF

FGF-8

FGF-9

FGF-10

FGF-16

FGF-17

FGF-18

FGF-19

FGF-20

sFGFR-1 (IIIc) / Fc Chimera

sFGFR-2 (IIIc) / Fc Chimera

sFGFR-3 / Fc Chimera

sFGFR-4 / Fc Chimera

sFlt-1 (native)

sFlt-1 (D3)

sFlt-1 (D4)

sFlt-1 (D5)

sFlt-1 (D7)

Flt3-Ligand

sFlt-4

sFlt-4/ Fc Chimera

Follistatin

FSH

Fractalkine/ CX3C

G-CSF

α-Galactosidase A

Galectin-1

Galectin-3

Gastrointestinal CA

GCP-2

GDF-3

GDF-9

GDF-11

GDNF

GLP-1

Glucagon

Goserelin

GM-CSF

GPBB

GROα

GROβ

GROγ

GRO/MGSA

Growth Hormone

Growth Hormone BP

GST-p21/WAF-1

HB-EGF

HCC-1

HGF

Histdyl-tRNA synthetase

Histrelin

HRG1-β1

I-309

I-TAC

IFN-α

IFN-α A

IFN-α 2a

IFN-α 2b

IFN-β

IFN-γ

IFN-Omega

IGF-I

IGF-II

proIGF-II

IGFBP-1

IGFBP-2

IGFBP-3

IGFBP-4

IGFBP-4

IGFBP-5

IGFBP-6

IGFBP-7

IL-1α

IL-1β

Browse our web site of recombinantproteins, including cytokines, growthfactors, chemokines and neurotrophins.Daily shipping and competitive pricing areoffered. Bulk quantities of many proteinsavailable. Cell Sciences also carries

corresponding antibodies and ELISA kits.

IL-2

IL-3

IL-4

sIL-4 Receptor

IL-5

IL-6

sIL-6 Receptor

IL-7

IL-8 (72 a.a.)

IL-8 (77 a.a.)

IL-9

IL-10

IL-11

IL-12

IL-13

IL-13 analog

IL-15

IL-16 (121 a.a.)

IL-16 (130 a.a.)

IL-17

IL-17B

IL-17D

IL-17E

IL-17F

IL-19

IL-20

IL-22

IL-31

Insulin

IP-10

JE

JNK2a1

JNK2a2

KC / CXCL1

KGF

L-asparaginase

LAG-1

LALF Peptide

LAR-PTP

LC-1

LBP

LD-78β

LDH

LEC/NCC-4

Leptin

LIGHT

LIX

LKM

LL-37

Lymphotactin

sLYVE-1

M-CSF

MCP-1 (MCAF)

MCP-2

MCP-3

MCP-4

MCP-5

MDC (67 a.a.)

MDC (69 a.a.)

MDH

MEC

Mek-1

MIA

Midkine

MIG / CXCL9

MIP-1α / CCL3

MIP-1β / CCL4

MIP-3 / CCL23

MIP-3α / CCL20

MIP-3β / CCL19

MIP-4 (PARC) / CCL18

MIP-5 / CCL15

MMP-3

MMP-7

MMP-13

Myostatin

Nanog

NAP-2

Neurturin

NFAT-1

beta-NGF

NOGGIN

NOV

NP-1

NT-1/BCSF-3

NT-3

NT-4

Ocreotide

Oncostatin M

Osteoprotegerin (OPG)

OTOR

Oxytocin

p38-α

Parathyroid Hormone

PDGF-AA

PDGF-AB

PDGF-BB

Persephin

PF-4

PIGF-1

PIGF-2

PKA α-subunit

PKC-α

PKC-γ

Pleiotrophin

PLGF-1

Polymyxin B (PMB)

PRAS40

PRL-1

PRL-2

PRL-3

Prokineticin-2

Prolactin

Protirelin

PTHrP

PTP1B

PTP-IA2

PTP-MEG2

PTP-PEST

sRANK

sRANKL

RANTES

RELM-α

RELM-β

Resistin

RPTPβ

RPTPγ

RPTPμ

SCF

SCGF-α

SCGF-β

SDF-1α

SDF-1β

Secretin

SF20

SHP-2

STAT1

c-Src

TACI

TARC

TC-PTP

TECK

TFF2

TGF-α

TGF-β1

TGF-β2

TGF-β3

Thymosin α1

sTIE-1/Fc Chimera

sTIE-2/Fc Chimera

TL-1A

TNF-α

TNF-β

sTNFR1

sTNFR2

TPO

TRAIL/Apo2L

sTRAIL R-1 (DR4)

sTRAIL R-2 (DR5)

TSH

TSLP

TWEAK

TWEAK Receptor

Urokinase

VEGF121

VEGF145

VEGF165

VEGF-C

VEGF-C I525

EG-VEGF

VEGF-E

HB-VEGF-E

sVEGFR-1

sVEGFR-2

sVEGFR-3

WISP-1

WISP-2

WISP-3

WNT-1

Page 3: Be the next winner! · • Ability to e-mail full-textlinks. •The latestnewsfromScienceNOW. • Career advice articles from Science Careers. • Access to theScience weekly podcastand

They say you never know when inspiration will strike.Download the Sciencemobile app for Android devicesand be ready the next time you’re inspired to read thelatest news, research, and career advice from Science

on yourmobile phone.

Features include:

• Summaries and abstracts fromScience, Science TranslationalMedicine, and Science Signaling.

• Ability to e-mail full-text links.

• The latest news from ScienceNOW.

• Career advice articles fromScience Careers.

• Access to the Science weeklypodcast and othermultimedia.

• Content caching for readingwithout wi-fi access.

i ti ill t ik F

Science Mobile AppNow Available for Android Phones

To download the Sciencemobile app for Android visit

content.aaas.org/mobile,visit the Android Market

on your phone, or justscan this barcode.

Page 4: Be the next winner! · • Ability to e-mail full-textlinks. •The latestnewsfromScienceNOW. • Career advice articles from Science Careers. • Access to theScience weekly podcastand

Mix it up.RE-Mix

Restriction EnzymeMaster Mixes

Restriction enzyme digests are now even easier!

The same high quality restriction enzymes that

you have come to trust from New England Biolabs

are now available in master mix format, including

enzyme, buffer and loading dye; simply add your

DNA and digest.

With RE-Mix Master Mixes take advantage of:

• Simpli�ed and shortened protocols

• Fast digestion in 15 minutes

(Time-Saver quali�ed)

• High product quality

with reproducible results

RE-Mix Master Mixes – just add your DNA and mix

For more information, visit

www.NEBREMIX.comBlue-footed Booby (Sula nebouxii)

© Tui De Roy

L 5 min 15 min 1 hr o/n

To experience the new

restriction enzyme

challenge from NEB, visit

www.NEBcutitout.com

GTAGCT

T

AGT

CT

C

T

GA

GATACGG

A C

G

A

C

Page 5: Be the next winner! · • Ability to e-mail full-textlinks. •The latestnewsfromScienceNOW. • Career advice articles from Science Careers. • Access to theScience weekly podcastand

the essential protein engineering summit

DISCOVERY

• Phage & Yeast Display

• Engineering Antibodies

• Antibody Optimization

EXPRESSION

• Difficult to Express Proteins• Optimizing Protein Expression• Purifying Antibodies

ANALYTICAL

• Characterization of Biotherapeutics• Protein Aggregation and Stability• Immunogenicity

ANTIBODIES

• Antibodies for Cancer Therapy• Bispecific Antibodies• Antibody-Drug Conjugates

Please reference keycode L35when registering.

PHARMA-BIOPARTNERING

FORUMS

NEW April 28 – April 29

Emerging Antibodyand Protein EngineeringPartnering Forum

PEGSummit.com

Organized by Cambridge Healthtech Institute250 First Avenue, Ste 300, Needham MA, 02494

PHONE: 415.883.0128 | FAX: 415.883.0572EMAIL: [email protected] | WWW.SUTTER.COM

High Speed

Wavelength Switcher

This complete illumination systemwith improved digital servotechnology allows 30% greaterlight output and switching times ofup to 0.5msec. The unique opticaldesign uses modern interferencefilters, providing integral blockingcharacteristics 1000 times betterthan typical monochromators.

FEATURES

� �������� ������ ��� ��������switching

� ������� � �������

� �������� ���������

� �������� ������ ������ �������

� ��� ������� ��� �������� �����position

� ����� ������

� ����� ��� ������ ��� ������

LAMBDA DG-4/DG-5 PLUS

FOCUS ON CAREERS

Postdoc Positions

In This Issue

One of the most important skills to demonstrate in a postdoc appoint-

ment is the ability to acquire funding. Whether it is in the form of grants,

fellowships, or out-right gifts, postdocs have to �nd ways to bring in the

bucks, not only to keep their own research enterprise humming, but

also to show future employers that they have experience raising money.

Since most postdocs don�t have a wealthy, anonymous benefactor or a

venture capitalist relative who can provide unlimited reserves for their in-

vestigations, it is up to the early career scientist to get creative in �nding

funding. More and more postdocs (and even grad students) are dem-

onstrating their ingenuity in where and how they seek and secure the

necessary research resources.

See full story on page 1246.

Upcoming FeaturesCancer Research: Vaccine Drug Development�March 23

Bioclusters: Eastern United States�April 6

Bioclusters: Western United States�May 4

Produced by the Science/AAAS Custom Publishing Office

The CreativeFundraiserThe Many Roles of the

Postdoc in Search

of Support

Page 6: Be the next winner! · • Ability to e-mail full-textlinks. •The latestnewsfromScienceNOW. • Career advice articles from Science Careers. • Access to theScience weekly podcastand

$350 in new research facilities

million investment

thousand Sq Ft REsearch park

for technology incubation700stem faculty members

National Academy members

being recruited globally

recently joined

60

5

Learn how current eventsare impacting yourwork.ScienceInsider, the new policy blog from the journalScience, is your source for breaking news and instant

analysis from the nexus of politics and science.

Produced by an international teamof science journalists,

ScienceInsider offers hard-hitting coverage on a range of

issues including climate change, bioterrorism, research

funding, andmore.

Before research happens at the bench, science policy is

formulated in the halls of government.Make sure you

understand how current events are impacting your work.

Read ScienceInsider today.

www.ScienceInsider.org

Breaking news and analysis fromthe world of science policy

Page 7: Be the next winner! · • Ability to e-mail full-textlinks. •The latestnewsfromScienceNOW. • Career advice articles from Science Careers. • Access to theScience weekly podcastand

1243www.sciencemag.org/products SCIENCE VOL 335 9 MARCH 2012

Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are

featured in this space. Emphasis is given to purpose, chief characteristics, and availability of products and materials. Endorsement by Science or AAAS of any products or

materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

Electronically submit your new product description or product literature information! Go to www.sciencemag.org/products/newproducts.dtl for more information.

ENDOTOXIN REMOVAL

The High Capacity Endotoxin Removal Resin is designed for the

cleanup of protein that is injected or transfected into cells or animals.

The Pierce High Capacity Endotoxin Removal Resin combines po-

rous cellulose beads and an FDA-approved food preservative, poly

(�-lysine), as an af� nity ligand to selectively bind endotoxins. Endo-

toxin levels in protein samples are reduced by greater than 99% in

as little as one hour using a spin cup format, and protein recovery

is greater than 85%. The Pierce High Capacity Endotoxin Removal

Resin peptides have a high af� nity for the charged glycol-groups

of an endotoxin, while the particle pores help trap endotoxins. The

modi� ed polylysine af� nity ligand eliminates the toxicity concerns as-

sociated with alternative technologies that use polymixin B ligands

and sodium deoxycholate buffers. The Pierce High Capacity En-

dotoxin Removal Resin is available in either bulk slurry packages

for researchers who want to pack their own columns or convenient,

single-use, spin-column formats.

Thermo Fisher Scienti� c

For info: 800-874-3723 www.thermoscienti� c.com/pierce

AUTOMATED STAGE SYSTEM

The NZ400 NanoScan Piezo Stage System is well suited for re-

searchers producing rapid Z sections and live cell 3-D images of

specimens grown in well plates, large petri dishes, or mounted to

glass slides. With the ability to create a stack of images using multi-

ple objectives in the z-axis with nanometer precision at an amazingly

high speed, the NanoScan is the perfect accessory for any 3-D im-

aging application. The NZ400 NanoScan Piezo Stage System offers

400 �m of travel, 2.5 nm repeatability, and closed loop control uti-

lizing a subangstrom resolution piezo resistive sensor. Designed to

mount to the Prior ProScan H117 series of high precision motorized

stages, the NZ400 can also be provided as a standalone device that

can be mounted onto a wide range of XY stages. Compatible with

most leading imaging software packages, the NZ400 comes stan-

dard with control inputs for RS232, USB, and 0–10 V analog input.

Prior Scienti� c

For info: 800-877-2234 www.prior.com

APOPTOTIC BODY DNA ANALYSISThe D-Pop Kit simpli� es the capture of DNA-containing particles

from cell-free biological samples such as blood serum and plasma,

urine, and eukaryotic cell culture media, and the extraction of DNA

from the captured particles. Using the D-Pop Kit, apoptotic bodies

and potentially other large particles are captured from biological � u-

ids in minutes by passing them through a � lter in a syringe format.

The � lter is then removed to a microfuge tube and the DNA is ex-

tracted from it using a rapid solid-phase extraction of DNA with non-

organic reagents. The D-Pop Kit also includes control polymerase

chain reaction primers for the hTERT gene to verify concentration

and recovery of DNA from the sample.

Bioo Scienti� c

For info: 888-208-2246 www.biooscienti� c.com

UV CROSSLINKER A new high quality, inexpensive ultraviolet crosslinker makes it

possible to identify and analyze trace amounts of DNA/RNA with

far greater sensitivity, accuracy, and speed than with conventional

analysis. The Select XLE-Series UV crosslinker covalently binds

nucleic acids to membranes in less than 30 seconds—240 times

faster than vacuum-oven baking. It has a unique true-ultraviolet

(UV)-monitoring circuitry that safeguards valuable test results from

washouts, even when the tubes age. Researchers also rely on

this versatile instrument for eliminating polymerase chain reaction

(PCR) contamination, nicking ethidium-bromide-stained DNA in

agarose gels, gene mapping for creating cleavage-inhibiting thy-

mine dimers, RecA mutation screening in E. coli, UV sterilization,

and miscellaneous UV-dosage applications. The Select Series

crosslinker features a “smart” user-friendly, fully programmable

microprocessor, built-in “help” messages and an auto-repeat func-

tion that make its operation amazingly fast and simple. It features

� ve 8 W tubes and is available in a choice of 254 nm, 312 nm, and

365 nm versions.

Spectronics Corporation

For info: 800-274-8888 www.spectroline.com

BIOLOGICAL SAMPLE STORAGEBiOS is an automated system designed for ultralow temperature storage of

sensitive biological samples. This � exible, scalable system ensures the integ-

rity of 250,000 to more than 10 million sample tubes at temperatures down

to -85�C. All samples within the BiOS are stored in -85°C chest freezer com-

partments to maintain temperature stability. All internal work� ows, including

sample picking, are optimized to keep samples at ultralow temperatures at all

times. System parts are easily accessible for service and maintenance. One-

and two-dimensional barcode reading and sample tracking produce complete

chain-of-custody documentation, with software tools to support 21 CFR Part

11 compliance. Multiple redundant backup systems ensure the samples stay

at -85°C, even in emergencies. The BiOS can store and process multiple lab-

ware types in the same system.

Hamilton Storage Technologies

For info: 800-310-5866 www.hamilton-storage.com

New Products

Produced by the Science/AAAS Custom Publishing Office LLIIFFEE SSCCIIEENNCCEE TTEECCHHNNOOLLOOGGIIEESS

Page 8: Be the next winner! · • Ability to e-mail full-textlinks. •The latestnewsfromScienceNOW. • Career advice articles from Science Careers. • Access to theScience weekly podcastand

LOCATION: Hemlock Bar

ARTICLE: Quantum Simulation

of Frustrated Classical Magnetism

in Triangular Optical Lattices

DATE: Sep 21, 9:21pm

LOCATION: University Faculty Lounge

ARTICLE: The Visual Impact of Gossip

DATE: Sep 21, 4:22pm

LOCATION: Gyro King

ARTICLE: Cavemen Craved

Carbs, Too

DATE: Sep 21, 1:13pm

LOCATION: Bed

ARTICLE: Consciousness:

What, How and Why

DATE: Sep 21, 10:56pm

LOCATION: Jackson Park Health Club

ARTICLE: An Electronic Second Skin

DATE: Sep 21, 7:43am

The new Science Reader app for iPad® from AAAS puts Science in your

hands, wherever you go. Read abstracts, career advice, and highlights

from our newest journals, Science Signaling and Science Translational

Medicine. Plus, AAAS members can access full text articles from Science.

Visit iTunes App StoreSM or content.aaas.org/ipad for details.

A new way to look at science

Page 9: Be the next winner! · • Ability to e-mail full-textlinks. •The latestnewsfromScienceNOW. • Career advice articles from Science Careers. • Access to theScience weekly podcastand

E1 Activating - E2 Conjugating

E3 Ligase - Deconjugating - Ubiquitin

SUMO - NEDD8 - ISG15 - UFM1 - Autophagy

FAT10 - Small Molecule Inhibitors - Antibodies

Kits - Substrate Proteins - Affinity Matrices

Increasing the quality, reliability, and

speed of ubiquitin-related discovery

Orders: 1.800.343.7475 I Technical Support: [email protected] I Inquiries: [email protected]

For more information:

www.bostonbiochem.com

The World’s Leading Producer of Ubiquitin-Related Research Products