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HANDS-ON INQUIRY-BASED SCIENCE EDUCATION

TMBIO-RAD

How can your students help save the Giant Pandas?

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Can the Giant Panda population be saved?With decreased habitat and low birth rates, the survival of the Giant Panda population depends on the dedicated support of scientists and caregivers. Let your students use the samecutting-edge combination of endocrinology and immunology that scientists use to determinethe right time frame for optimal fertility.

New A Giant Panda Problem Kit for AP Biology — a ThINQ! Investigation

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Use the power of ELISAA Giant Panda Problem for AP Biology, the newest ThINQ! Investigation,puts your students in the role of conservation scientist. Using the powerof ELISA, a highly specific immune-detection assay, your students will check simulated panda urinesamples for the biomarkers of apotential pregnancy complication.Then, in a structured, guided, oropen inquiry investigation yourstudents will design their ownELISA assay to predict ovulation in four pandas.

Ordering Information

17002878EDU A Giant Panda Problem Kit for $138.00AP Biology — Available this summer

1662401EDU ELISA Kit Reagent Refill Pack 104.00

1662400EDU Classic ELISA Immuno Explorer Kit 138.00For a skills-based approach, try the classic version.

Visit bio-rad.com/mail/panda for more kit information.

Coming this summer!

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Dispel the misconception that plants only photosynthesize.The easy-to-use premade algae beads included in this kitare part of a simple system that combines these two energyfunctions into a single hands-on lab. Teach photosynthesisand cellular respiration in a single class period.

Energy transfer your students can actually see!Microalgae encapsulated in alginate — algae beads —cause a vibrant shift in the color of indicator solution, from yellow to red to purple, depending on whetherphotosynthesis or cellular respiration is dominant. Plus, the algae beads are reusable for multiple class periods!

New Photosynthesis and Cellular Respiration Kit for AP Biology — a ThINQ! Investigation

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Ordering Information EDU Price

17001238EDU Photosynthesis and Cellular Respiration Kit for AP Biology $145.00

12002353EDU Photosynthesis and Cellular Respiration Reagent Refill Pack 119.00

Visit bio-rad.com/mail/ThINQAlgae or call 1-800-424-6723 for more information and for a list of required equipment/accessories for this laboratory activity.

Now available!

Biofuel Reactions Enzyme Kit for AP Biology — a ThINQ! Investigation

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Mushroom ecology impacts biofuel engineeringMushrooms use the enzyme cellobiaseto break down plant material for accessto the nutrients of host plants. Theproduct of that enzymatic reaction isglucose, which can be fermented into biofuel. But not all cellobiases areequal. How and where a mushroomspecies grows relates to its cellobiaseactivity. Which type is best for biofuel production?

Ordering Information EDU Price

17001235EDU Biofuel Enzyme Reactions Kit for AP Biology $135.00

1665036EDU Biofuel Enzyme Kit Reagent Refill Pack 84.00

1665035EDU Classic Biofuel Enzyme Kit 135.00For a skills-based approach try the classic version.

Visit bio-rad.com/mail/ThINQBiofuel or call 1-800-424-6723 for more information and for a list ofequipment/accessories required for these laboratory activities. Page 7

Fueling the world with bioengineeringHave your students assume the role of bioengineer as they design experiments to optimize the function of cellobiase, a key enzyme in the conversion of cellulose into biofuel. Students extract cellobiase from mushrooms and then discover the effects of temperature, pH, and enzyme and substrate concentrationson the reaction rate — a flexible exploration in enzyme kinetics.

Parasitic Mushrooms feast on nutrients from their livinghost. If their cellobiase activity ishigh, will they kill the host?

Saprophytic mushrooms are the cleanup crew. They drawnutrients from dead and decayingmaterial. How active do youexpect their cellobiase to be?

Mycorrhizal mushrooms form beneficial symbioses with plant roots. Should theircellobiase activity be high?

pGLO™ Transformation and Inquiry Kit for AP Biology — a ThINQ! Investigation

Ordering Information EDU Price

1660335EDU pGLO Transformation and Inquiry Kit for AP Biology $179.00

1660555EDU Transformation Reagent Refill 62.00Contains consumables for core pGLO transformation.

1660336EDU pGLO Inquiry Reagent Refill Pack 89.00Contains consumables for inquiry extension investigations.

1660003EDU Classic pGLO Bacterial Transformation Kit 95.00For a skills-based approach try the classic version.

Visit bio-rad.com/mail/ThINQpGLO or call 1-800-424-6723 for more information and for a list ofequipment/accessories required for this laboratory activity.

Take pGLO transformation in new directions Dive deeper into the pGLO Transformation lab by exploring transformationefficiency, the roles of ampicillin and arabinose, and the presence of satellitecolonies. The kit comes with all the materials for the classic pGLOtransformation plus these inquiry activities.

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Enjoy the art of science — a coloring page for you and your students

Visit the Explorer Community at bio-rad.com/mail/art for the full science coloring page activity and other helpful classroom resources.

Educational Pricing Contract ApplicationAs an educator you are entitled to discount pricing on all Bio-Radproducts. To create a new education account, simply fax or mailthis page to Bio-Rad. If you are ready to place your first order,send this page with a purchase order with the numbers anddescriptions of the items you wish to purchase.

Bio-Rad Explorer Program Bio-Rad Laboratories, Inc.2000 Alfred Nobel DriveHercules, CA 94547 USA

Fax to 1-800-879-2289 or 1-510-741-5800.

Re: Educational DiscountWe are an educational facility interested in using Bio-Radproducts to teach our students. We would like to receive ateaching lab discount and understand that the Bio-Radeducation discount is available only to educators at the K–12and undergraduate levels. This letter is our confirmation that theproducts we order through our educational account will be usedonly to educate students in a classroom or teaching labenvironment and will not be used for basic scientific research.We are sending this letter in order to:

o Create a new educational account with Bio-Rad Laboratories (if tax exempt, please include a copy of the school’s tax certificate)

o Place a new order, with PO attached o Confirm an order identification number (please fill in

order number)

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Bio-Rad Explorer™ Program Educational Pricing Contract Application

o Free Bio-Rad Explorer catalog (bulletin 2112)

o I would like to receive the Bio-Rad eFocus email newsletter

We want to hear from you! What science classes do you teach?

Which life science skills would you like to see addressed in a kit?

o Please have a Bio-Rad curriculum training specialist contact us about meeting our teaching goals and professional development needs in our own district today.

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Fill in and return this card today or visit us online at bio-rad.com/mail/explorercatalogto request your free catalog. For immediate information, call 1-800-424-6723.

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Free 2017Bio-Rad Explorer™

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Get the Bio-Rad Explorer Catalog — Captivating Science Education for Your Students

Looking for exciting hands-on activities for your students?

Visitbio-rad.com/mail/explorercatalog

to request your free copy of the

2017 Bio-Rad Explorer Catalog.

2017 Teacher Conference and Workshop ScheduleGo to bio-rad.com/explorerworkshops for a complete schedule.

2017

March 30–April 2NSTA National Los Angeles, CA

October 5–7NSTA Regional Baltimore, MD

November 9–11STAT CAST Houston, TX

November 9–11NSTA Regional Milwaukee, WI

November 9–12NABT National St. Louis, MO

November 30–December 2NSTA Regional New Orleans, LA

December 6–9ACTE Nashville, TN

2018

March 15–18NSTA National Atlanta, GA

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B U S I N E S S R E P LY M A I LFIRST CLASS PERMIT NO 42 RODEO, CALIF

POSTAGE WILL BE PAID BY ADDRESSEE

Bio-Rad Laboratories, Inc.2000 Alfred Nobel DriveHercules, CA 94547-9980

Join Us at Our Free Hands-On Workshops at a 2017 Teacher Conference

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Curriculum Training Specialists — Local Support and Training

Damon Tighe

damon_tighe@bio-rad.combio-rad.com/damontighe

Leigh Brown

leigh_brown@bio-rad.combio-rad.com/leighbrown

Tamica Stubbs

tamica_stubbs@bio-rad.combio-rad.com/tamicastubbs

Sherri Andrews, PhD

sherri_andrews@bio-rad.combio-rad.com/sherriandrews

Find free training, new activities, and curriculum support for your life science classroom! Our Curriculum Training Specialists (CTSs)have years of classroom experience tohelp you with your curriculum and productneeds. Contact your local CTS to find outwhat free professional development eventsare upcoming in your area, schedulepersonalized on-site training, and get helpwith curriculum and product selection.

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Is crime scene DNA evidence always enough for a conviction?

A powerful tool in forensicsDNA evidence has the power toexonerate the falsely accused and to clinch a conviction of the guilty. But, is DNA evidence always enough?

Your students are the investigatorsHave your students take on the role of investigator to gather and analyzeDNA evidence from a crime scene tocompare with the DNA of suspects.Then, hold a mock trial to discusswhether the evidence is sufficient to convict.

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Forensic DNA Fingerprinting KitUse restriction enzymes to digestcrime scene DNA and match thebanding pattern with that of suspect DNA.

● Low equipment requirements● Aligned with AP Big Ideas 3 and 4

Crime Scene Investigator PCR Basics KitUse PCR to amplify a short region from a crime scene and five suspectDNA samples. Find the match todetermine who was at the scene of thecrime using the same techniques andstatistical analysis as forensic scientists.

Ordering Information EDU Price

1660007EDU Forensic DNA Fingerprinting Kit $134.00 Free curriculum manual is available online for download.

Visit bio-rad.com/mail/fingerprinting for more information.

Ordering Information EDU Price

1662600EDU Crime Scene Investigator $176.00PCR Basics Kit (conventional PCR)

1662660EDU Crime Scene Investigator PCR 552.00Basics Real-Time PCR Starter Kit

Visit bio-rad.com/mail/crimescene or call 1-800-424-6723 for more information and for a list of equipment/accessories required for these laboratory activities.

GMO Investigator™ Kit — the GMO debate rages on!

Ordering Information EDU Price

1662500EDU GMO Investigator Kit $187.00

1660450EDU Small Fast Blast™ DNA 54.00Electrophoresis Reagent Pack

1662550EDU GMO Investigator Kit 234.00 Plus Small Fast Blast DNA Electrophoresis Reagent Pack

1662560EDU GMO Investigator Real-Time 560.00PCR Starter Kit

Visit bio-rad.com/mail/GMO or call 1-800-424-6723 for more informationand for a list of required equipment/accessories for this laboratory activity.

Are GM crops a good thing? Have your students detectGMOs in the foods they eat every day. Then hold a debate!It’s a great way to add engaging and relevant context to theconcepts of genetics, DNA, and PCR.

Visit bio-rad.com/mail/GMOdebate to download our GMO debate activity, including starter questions and resources.

Try it in real time with the GMO Investigator Real-Time PCR Starter Kit. See our currentreal-time PCR promotion on page 19.

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The open-ended, inquiry-based Protein ProfilerModule moves beyond DNA and allows students to utilize the most widely used life scienceresearch technique, protein electrophoresis,to study protein structure and function.Students learn to use SDS-PAGE togenerate protein profiles from muscles of both distantly and closely relatedspecies of fish. From their results, theycompare the different species’ profiles to test the hypothesis that protein profiles can be indicators of evolutionary relatedness.

Comparative Proteomics Kits — Evolutionary! — AP Big Ideas 1, 3, and 4

Ordering Information EDU Price

1662700EDU Comparative Proteomics Kit I: $178.00Protein Profiler Module

1662850EDU Comparative Proteomics Kits I 370.00and II: Protein Profiler and Western Blot Modules

1662875EDU Rapid Blotting and V3 Western 574.00Workflow™ Starter Kit

Visit bio-rad.com/mail/proteinprofiler or call 1-800-424-6723 formore information and for a list of required equipment/accessories forthese laboratory activities.

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Physical Sciences Disciplinary Core IdeasPS1: Matter and Its InteractionsPS2: Motion and Stability: Forces and InteractionPS3: Energy

Life Sciences Disciplinary Core IdeasLS1: From Molecules to Organisms: LS2: Ecosystems: Interactions, Energy, and Dynamics

Structures and Processes LS3: Heredity: Inheritance and Variation of TraitsLS4: Biological Evolution: Unity and Diversity

H H H H IH H H HH H H HH H H IH H H HH H HH H HH H H H HH H H H HH H H H HH HH HH HHH HH HH H H H HH H HH H HH HH H H H HH H H H HH H H H HH H H H H HH H H H HH H H I HH H H H H HH H H H HH H H H HH H H

Science Framework Kit Selection Guide

SEP

LS1

LS2

LS3

LS4

PS1

PS2

PS3

AD

V

Visit explorer.bio-rad.com to learn more.

C. elegans Behavior Kit (1665120EDU) — AP Big Ideas 1, 2, 3, 4 IDEA Kit — Inquiry Dye Electrophoresis Activity (1665075EDU)STEM Electrophoresis Classroom Kit (1665090EDU)Biofuel Enzyme Kit (1665035EDU) Biofuel Reactions Enzyme Kit for AP Biology: A ThINQ!™ Investigation (17001235EDU) — AP Big Ideas 1, 4 < New!

Microbes and Health Kit (1665030EDU)Genes in a Bottle™ Kit (1662300EDU) — AP Big Idea 3Photosynthesis and Cellular Respiration Kit: A ThINQ! Investigation (17001238EDU) — AP Big Ideas 1, 2, 4 < New!

pGLO™ Bacterial Transformation Kit (1660003EDU) — AP Big Ideas 1, 2, 3, 4pGLO Transformation and Inquiry Kit for AP Biology: A ThINQ! Investigation (1660035EDU) — AP Big Ideas 1, 2, 3, 4Green Fluorescent Protein Chromatography Kit (1660005EDU)Secrets of the Rainforest™ Kit (1660006EDU)Size Exclusion Chromatography Kit (1660008EDU)Got Protein?™ Kit (1662900EDU)ELISA Immuno Explorer™ Kit (1662400EDU) — AP Big Idea 2A Giant Panda Problem Kit for AP Biology (17002878EDU) — AP Big Ideas 2, 4 < New! Available summer 2017

Forensic DNA Fingerprinting Kit (1660007EDU) — AP Big Ideas 3, 4Analysis of Precut Lambda DNA Kit (1660001EDU) — AP Big Idea 3Restriction Digestion and Analysis of Lambda DNA Kit (1660002EDU) — AP Big Idea 3pGLO Kit SDS-PAGE Extension (1660013EDU) — AP Big Idea 3Crime Scene Investigator PCR Basics™ Kit (1662600EDU) — AP Big Idea 3Comparative Proteomics Kit I: Protein Profiler Module (1662700EDU) — AP Big Ideas 1, 3, 4Comparative Proteomics Kit II: Western Blot Module (1662800EDU)Fish DNA Barcoding Kit and DNA Barcoding Sequencing Module (1665100EDU and 1665115EDU) — AP Big Ideas 1, 2, 3, 4PV92 PCR Informatics Kit (1662100EDU) — AP Big Ideas 1, 3GMO Investigator™ Kit (1662500EDU)Crime Scene Investigator PCR Basics Real-Time PCR Starter Kit (1662660EDU)GMO Investigator Real-Time PCR Starter Kit (1662560EDU)Cloning and Sequencing Explorer Series (1665000EDU) — AP Big Ideas 1, 2, 3, 4Protein Expression and Purification Series (1665040EDU, 1665045EDU, or 1665050EDU)

Legend: H Content contained in kit curriculumI Content addressed in extension activities

SEP: Science and Engineering PracticesADV: Advanced Scientific Practices

Introd

uctory

Intermed

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dvanced

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Limit one per customer. Discounts and specials may not be combined with other promotional offers. Promotional offers expire August 31, 2017. Call 1-800-424-6723 to order or visit bio-rad.com/mail/explorerpromos for more information.

Free Real-TimePCR Kit

with CFX Connect™ purchase

A complete real-time investigation!Receive a free GMO Real-Time PCRStarter Kit (1662560EDU) with purchase ofa CFX Connect Real-Time PCR DetectionSystem for $20,560 (1855201EDU) — a$560 savings. Must use online promo codeREALTIMEGMO17US or quote #17-Q06314when ordering.

Free Pipetswith Electrophoresis

Lab Set purchase

The right pipets to simplify prepReceive a 20–200 µl (1660552EDU) and a100–1,000 µl digital micropipet free(1660553EDU) with purchase of a DNAElectrophoresis Instructional Lab Set for$2,000 (1660706EDU) — more than a $274savings. Must use online promo codePIPETSET17US or quote #17-Q06316 when ordering.

Free UView™

Loading Dye & Stainwith kit purchase

Fast, cleaner, and saferDNA visualization

Receive a free 200 µl tube of UView 6xLoading Dye and Stain (1665111EDU) withpurchase of a Forensic DNA FingerprintingKit for $134 (1660007EDU) — a $25 savings.Must use online promo code UVIEWDNA17USor quote #17-Q06313 when ordering.

Get ready for next year with these savings!Visit bio-rad.com/mail/explorerpromos for ordering details

Bio-Rad Laboratories, Inc.2000 Alfred Nobel DriveHercules, CA 94547

1-800-424-6723

Address service requested

PRESORTED STDU.S. POSTAGE

PAIDCarol Stream, ILPermit No. 1369

Bio-Rad Explorer™ Newsletter / Volume 9

Ready to use,reliable, andreusableAlgae beadsare now available!With fast and easy prep, yourstudents can design their own algaebead experiments right away usingBio-Rad’s new Photosynthesis and Cellular Respiration Kit. Visitbio-rad.com/mail/ThINQAlgaefor more details and orderinginformation. Also see page 4.

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