beapartofsirtris: world-class,headlinescience · 2008-10-22 · in the u.s., call toll free at...

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Be a part of Sirtris: World-class, headline science At Sirtris, our phenomenal team is making headlines, from Forbes to Fortune, because of one thing - our passion for creating therapies that allow people to live longer, healthier lives. We’ve developed a culture that not only rewards creativity, but celebrates it - a community dedicated to groundbreaking science, in which we learn from one another, inspire one another and succeed together. To learn more about life at Sirtris and opportunities to join our team, visit www.sirtrispharma. com/careers. Recent Sirtris papers Nature. 2007 Nov 29;450(7170):712-6. Cell. 2006 Dec 15;127(6):1109-22. Nature. 2006 Nov 16;444(7117):337-42. www.sirtrispharma.com/careers Sirtris Says Its Product Helps Diabetics Lower Blood Sugar — Wall Street Journal The exclusive story of the biotech startup searching for anti-aging miracle drugs — Fortune Small molecule activators of SIRT1 as therapeutics for the treatment of Type 2 Diabetes — Nature

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Page 1: BeapartofSirtris: World-class,headlinescience · 2008-10-22 · In the U.S., call toll free at 1-800-4BIORAD (1-800-424-6723) ... subscription, or renew your university’s site license

Be a part of Sirtris:World-class, headline science

At Sirtris, our phenomenal team ismaking headlines, from Forbes to Fortune,

because of one thing - our passion for creating therapies that allow people to live longer, healthier

lives. We’ve developed a culture that not only rewards creativity, but celebrates it - a community

dedicated to groundbreaking science, in which we learn from one another, inspire one another

and succeed together.

To learn more about life at Sirtris and opportunities to join our team, visit www.sirtrispharma.

com/careers.

Recent Sirtris papers

Nature. 2007 Nov 29;450(7170):712-6.

Cell. 2006 Dec 15;127(6):1109-22.

Nature. 2006 Nov 16;444(7117):337-42.

www.sirtrispharma.com/careers

Sirtris SaysIts Product

Helps Diabetics

Lower Blood Sugar —Wall Stree

t Journal

The exclusive storyof the biotech startupsearching for anti-agingmiracle drugs— Fortune

Small molecule activators ofSIRT1 as therapeutics for thetreatment of Type 2 Diabetes

—Nature

Page 2: BeapartofSirtris: World-class,headlinescience · 2008-10-22 · In the U.S., call toll free at 1-800-4BIORAD (1-800-424-6723) ... subscription, or renew your university’s site license

R&D Systems Tools for Cell Biology Research™

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Key: H Human M Mouse

TRANSCRIPTION FACTOR SPECIES CONTROL PRIMERS CATALOG #

β-Catenin H SUZ12 ECP1329

c-Myc H p21 ECP3696

CREB H Fos ECP2989

FoxP3 H IL-2 ECP3240

GATA-4 H MUC4 ECP2606

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KLF4 H M B2R ECP3640, ECP3158

Nanog H Nanog ECP1997

Oct-3/4 H Nanog ECP1759

p53 H p21 ECP1355

p300 H Fos ECP3789

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STAT3 H M c-Myc ECP1799

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ExactaChIP Chromatin IP Kits

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The FoxP3 ExactaChIP™ Chromatin IP Kit (Catalog # ECP3240) was used to detect FoxP3binding sites in human Jurkat leukemic T cells stimulated with PMA + ionomycin.Afterincubation with biotinylated anti-human FoxP3 or biotinylated anti-goat IgG poly-clonal antibodies, the IL-2 promoter was detected by standard PCR using primerstargeting the IL-2 promoter. M=DNA marker; Input = total DNA before IP.

Active Gene

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Transcription

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Speci�cTranscription Factor

Histones

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Page 3: BeapartofSirtris: World-class,headlinescience · 2008-10-22 · In the U.S., call toll free at 1-800-4BIORAD (1-800-424-6723) ... subscription, or renew your university’s site license
Page 4: BeapartofSirtris: World-class,headlinescience · 2008-10-22 · In the U.S., call toll free at 1-800-4BIORAD (1-800-424-6723) ... subscription, or renew your university’s site license

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Page 5: BeapartofSirtris: World-class,headlinescience · 2008-10-22 · In the U.S., call toll free at 1-800-4BIORAD (1-800-424-6723) ... subscription, or renew your university’s site license

HeritageSigma is Cell Culture

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Page 6: BeapartofSirtris: World-class,headlinescience · 2008-10-22 · In the U.S., call toll free at 1-800-4BIORAD (1-800-424-6723) ... subscription, or renew your university’s site license

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Page 7: BeapartofSirtris: World-class,headlinescience · 2008-10-22 · In the U.S., call toll free at 1-800-4BIORAD (1-800-424-6723) ... subscription, or renew your university’s site license

�e AHFMR Polaris Award will support a comprehensive

theoretical and empirical research e�ort proposed by

Dr. McNaughton in the �eld of brain dynamics, information

coding, computation, and memory that will complement

ongoing research at the University of Lethbridge’s Canadian

Centre for Behavioural Neuroscience. �e Award will

support Dr. McNaughton’s relocation from the University

of Arizona to the University of Lethbridge to join the

renowned behavioural neuroscience team headed by

Dr. Bryan Kolb and Dr. Rob Sutherland. As well, the Award

will also support the recruitment of a research team of

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and the establishment of an advanced facility for neural

ensemble recording and cellular-level functional brain

imaging. In this way the AHFMR Polaris Award will

catalyze provincial, national, and international research

collaborations in the field of behavioral, systems, and

computational neuroscience, that will yield knowledge

and innovation for the benefit of Albertans and people

around the world, and train the next generation of

scientists in this field.

Potential graduate students and post-doctoral trainees

with interest and established skills in systems or cellular

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The Alberta Heritage Foundation for Medical Research (AHFMR) Polaris Award was created to

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Congratulations to Dr. Bruce McNaughton,

the inaugural winner of Alberta’s AHFMR Polaris Award

Page 8: BeapartofSirtris: World-class,headlinescience · 2008-10-22 · In the U.S., call toll free at 1-800-4BIORAD (1-800-424-6723) ... subscription, or renew your university’s site license

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Page 9: BeapartofSirtris: World-class,headlinescience · 2008-10-22 · In the U.S., call toll free at 1-800-4BIORAD (1-800-424-6723) ... subscription, or renew your university’s site license

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Page 10: BeapartofSirtris: World-class,headlinescience · 2008-10-22 · In the U.S., call toll free at 1-800-4BIORAD (1-800-424-6723) ... subscription, or renew your university’s site license

The last word on Science Signaling...

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Page 11: BeapartofSirtris: World-class,headlinescience · 2008-10-22 · In the U.S., call toll free at 1-800-4BIORAD (1-800-424-6723) ... subscription, or renew your university’s site license

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Page 12: BeapartofSirtris: World-class,headlinescience · 2008-10-22 · In the U.S., call toll free at 1-800-4BIORAD (1-800-424-6723) ... subscription, or renew your university’s site license

The pages of this journal aremade of recycled fiber.The staff of Science is doing its share to reduce, reuse, and recycle. The paper used in printing the pages

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Page 13: BeapartofSirtris: World-class,headlinescience · 2008-10-22 · In the U.S., call toll free at 1-800-4BIORAD (1-800-424-6723) ... subscription, or renew your university’s site license

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Page 15: BeapartofSirtris: World-class,headlinescience · 2008-10-22 · In the U.S., call toll free at 1-800-4BIORAD (1-800-424-6723) ... subscription, or renew your university’s site license

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