bert's february 2009 cv

Bert Gold, Ph.D., F. A. C. M. G.

6811 Kingfisher Court

Frederick, MD 21703

Daytime phone: 301-846-5098

Electronic mail: [email protected]

Country of citizenship: United States

Marital Status: Married, 1986; two children

Education Tufts University, Medford, MA 02155 Doctorate in Developmental Biology

August 1981 Washington University, St. Louis, MO Baccalaureate in Biology, May, 1976

Board Certifications

Diplomate in Clinical Molecular GeneticsAmerican Board of Medical Genetics, 1996Maintenance of Certification Granted until 2013National Provider Identification # 1831178094

Certified to Perform HIV testing by Roche Diagnostic Systems, 1998-99.

Certified as a Phlebotomist, American Society of Phlebotomy Technicians, 1996 (lapsed).

Professional Experience National Cancer Institute at Frederick, MD Staff Scientist December 2003-present Research Fellow Aug 2000 – Nov 2003

Chairman, Frederick Forum on Bioinformatics and Chemoinformatics 2003-2005; an interagency

initiative intended to bring together computationally savvy elements of NIAID, NCI, the United

States Military, and contractors to address strategies for solving complex problems. Dr. Lincoln

Stein of the Cold Spring Harbor Laboratory provided a tutorial and keynote address in June 2003,

Dr. Brian Foley of Los Alamos National laboratory provided a tutorial and keynote in October

2004. In January 2005, our guest was MacArthur award winner, Dr. Joseph DeRisi of UCSF.

Key Collaborator with the Center for AIDS Research at Dana-Farber Cancer Institute, Beth Israel

Deaconess Medical Center, and Children’s Hospital Boston on a project intended to better

understand the basis of Primate HIV resistance.

Albert Mark Gold, Ph.D., F.A.C.M.G.

Project leadership for a series of collaborations with NCI’s Division of Cancer Epidemiology and

Genetics (DCEG) and the National Institute of Mental Health (NIMH) Genes, Cognition and

Psychosis Program. These involve genotyping samples from ongoing studies of lung cancer,

dysplastic nevus/ cutaneous malignant melanoma, retinoblastoma, and studies of Nevoid

Basal Cell Carcinoma (Gorlin's syndrome) and psychiatric samples from patients diagnosed with

schizophrenia and providing technical support and guidance to investigators in these agencies.

For this project, Developed rapid, high-throughput, genotyping technology with collaborators at

Celera, Applied Biosystems and Roche Molecular Systems.

Project leader for investigating whether the common disease / common variant hypothesis

applies to human breast cancer with Dr. Kenneth Offit, Chief of Genetics at Memorial Sloan

Kettering Cancer Center. Formal collaborator on Dr. Offit’s funded studies with the Breast

Cancer Research Fund and Starr Foundation. Participant in Data Analysis group of Consortium

of Investigators of Modifiers of BRCA1/2 on BRCA2 Modifier gene scan being carried out at

Harvard/MIT Broad Institute.

Initiated a high performance computing in collaboration with the Advanced Biomedical Computing

Center (SAIC-Frederick), Human Genome Sciences, Inc. in Rockville, MD., and investigators at

National Institute of Neurological Diseases and Stroke (NINDS) in Bethesda, and the Baylor

College of Medicine’s Department of Molecular and Human Genetics, to annotate segmental

duplication and polymorphic short tandem repeats in the human genome and to provide

functional insight.

Developed and implemented several computational capabilities within the Human Genetics

Section of the Laboratory of Genetic Diversity, and later in the Laboratory of Experimental

Immunology. Among these are: (1) A database management system that can provide a complete

accounting for nearly 20,000 DNA samples and attendant data in the laboratory. (2) Application

of a series of programs that can calculate genetic haplotypes using both Expectation

Maximization (EM) and Bayesian algorithms from Case-Control data. (3) Programs that test the

significance of haplotype-disease associations through the use of permutation algorithms and (4)

A series of methods that measure linkage disequilibrium through SNP typing closely linked

markers.

2


Quest Diagnostics, Van Nuys, CA 91405 Research Manager and Clinical Scientist March 1997 – June 2000

Developed and operationalized tests worth $ 4 Million annually.

National oversight for Fragile X, Hereditary Hemochromatosis, Apo E, Factor V (Leiden) tests.

Bronze Impact Award from the Clinical Trials Center for Development and Validation of HIV

Ultrasensitive RT-PCR, HIV 1.5 version RT-PCR and CMV DNA PCR tests.

Supervised 6 highly skilled Bachelors and Masters level research assistants.

Served Role of Primary Corporate Liaison to Roche Diagnostic Systems.

Compared Proviral DNA Testing of HIV-1 with Viral Load Testing to measure infection status.

Devised several methods for hereditary hemochromatosis polymorphism typing in the SB

Genetic Testing Center as part of an exclusive proprietary diagnostic test purchased from

Mercator Genetics (which became Progenitor).

University of California, San Francisco, San Francisco, CA

Visiting Scientist

September 1995 – September 1996

Compiled 150 Clinical Molecular Genetics Cases to become Board Certified in Clinical Molecular

Genetics in 1996.

Organized Clinical Medical Genetics Review sessions for fellows studying to take cytogenetics

and molecular genetics board examinations.

Initiated collaboration with Center for Advanced Medical Information Systems (CAMIS) at

Stanford University to construct software to assist in prenatal genetic decision making.

3


Temple University Hospital, Philadelphia, PA 19149

Director, Molecular Pathology Laboratory

August 1993 – August 1995

Directed all phases of start-up, state-of-the-art laboratory devoted to molecular diagnosis for

infectious disease, oncology and prenatal applications.

Co-Investigator on a $ 700,000 grant documenting the connections between herpesviruses and

retroviruses in causing lymphoma.

Designed nine new diagnostic tests and was responsible for validating and reporting these on

time and within budget.

Marketed these tests to colleagues at other Delaware Valley Universities and researchers at Yale

and abroad.

Developed custom implementation plans and research proposals to bring diagnostic tests and

computer network for communicating results to fruition.

Recruited and managed one technician, three graduate students and an OB/GYN fellow with

skills in research, programming, and molecular biology, to staff the laboratory

University of Medicine and Dentistry of New Jersey, Camden, NJ 08103

Supervisor, Laboratory of Biochemical and Molecular Genetics

February 1990 – July 1993

Revenue accountability for $ 200,000 annual test service. Service supported physicians and

hospitals with prenatal diagnostic services including genetic counseling.

Managed 2 FTE medical technologists, unit secretary, two genetic counselors.

Negotiated clinical collaborations with physicians at The Johns Hopkins University School of

Medicine, Columbia College of Physicians and Surgeons, The National Research Center of the

American Red Cross, and IG laboratories.

Implemented expanded prenatal biochemical diagnostic testing including writing FORTRAN code

for published interpretative software.

4


Fellowships and Specialized Training MARHGN/NYMAC Symposium on Pharmacogenetics, Baltimore, MD, April 7, 2006.

Genetics Review Course, American College of Medical Genetics, Chicago, IL, June 2002.

Current Concepts in Clinical Molecular Genetics and Molecular Diagnostics, National Institutes of Health, Bethesda, MD, January-May, 2002.

Genetic Analysis of Complex Human Diseases Course, Duke University Medical Center, May 2001.

Sequence Analysis Course, U. of Maryland School of Medicine, Baltimore, MD, September 2000.

Genetics Review Course, Baylor College of Medicine, Houston, TX, June 1996.

Workshop in Fluorescent In Situ Hybridization, Oncor, Inc., Gaithersburg, MD January 1995.

Short Course in Experimental Mammalian Genetics, Jackson Labs., Bar Harbor, ME, July 1993.

Huntington Disease Workshop; Indiana University School of Medicine, Indianapolis, June1990.

Post-doctoral fellow, The Biological Laboratories, Harvard University, Cambridge, MA 1983-85.

Research fellow, Dana-Farber Cancer Institute & Harvard Medical School, Boston, MA 1982-83. Skills Extensive Computer Skills and Skills in Recombinant DNA and Genotyping. Computer skills include: Writing PERL, HTML, C, and Visual Basic code; Competence in UNIX, Microsoft, and Apple Operating Systems. Laboratory expertise includes clinical molecular test validation and formulation of GMP/GLP compliant test packages. Certificates

Board Certified in Clinical Molecular Genetics, American Board of Medical Genetics, 1996 (Qualified until 2013 through Maintenance of Certification).

Certified to Perform HIV testing by Roche Diagnostic Systems, 1998-99.

Certified as a Phlebotomist, American Society of Phlebotomy Technicians, 1996.

New York State Certificate of Qualification in Genetic Testing (Limited to DNA), 1997-2001.

5


Honors

Eliot Osserman Award for Distinguished Service, Israel Cancer Research Fund, New York 2008NCI-Staff Scientist/Staff Clinician Organization Achievement Award, NCI, NIH, 2008Director’s Intramural Innovation Award, Career Development Award, NCI, 2006Technology Transfer Award, Center for Cancer Research, National Cancer Institute, NIH, 2002Elected Ph. D. Fellow, American College of Medical Genetics, 2001.Bronze Impact Award, Quest Diagnostics, 1999.Outstanding Volunteer Service Award, VA Medical Center, San Francisco, 1997Foundation of UMDNJ Research Award, 1991.March of Dimes of Southern New Jersey Research Award, 1991.NIH Post-Doctoral Fellowship at Harvard University, 1983-85.Associate Member Sigma Xi at Tufts University, 1978Dean's List, Washington University, St. Louis, 1976.

Presentations

“Identification of a new breast cancer risk locus in a genome-wide association study of Ashkenazi Jews”ASCO Annual Meeting, Chicago, IL, June 2008

“A Genome-Wide Association Study Aimed at Breast Cancer Gene Discovery in Ashkenazi Jews”UCLA, Westwood, CA, April 22, 2008.

“The Hedgehog Pathway as a Chemotherapeutic Drug Target”Genentech, South San Franciso, CA, April 23, 2008.

“Estimating Human Recombination through Computational Methods”National Energy Research Supercomputing Center, Oakland, CA, April 24, 2008.

“The Role of the Hedgehog/Patched Pathway in Breast and Prostate Cancer Stem Cells”Institute for Cancer Research and Treatment, Candiolo, Torino, Italy, June 8, 2007.

“Some HH/PTCH Pathway Immunohistochemical Efforts and an Update on Breast Cancer Whole Genome Association” Johns Hopkins Cancer Center, Baltimore, MD, April 24, 2007.

“Evaluation of Whole Genome Differences between Ashkenazi Jews and CEUs as a Prelude to Whole Genome Association Studies” Cold Spring Harbor Laboratory, January 16, 2007.

“Genetic Counseling and New Genetic Technology” Howard Community College,Columbia, Maryland, December 1, 2005

“New Understandings of Steroid Pathway Genes and Breast Cancer” Memorial Sloan-KetteringCancer Center, New York, July 27, 2005.

“Genetics and Pediatrics: Present and Future”, 5o Congreso Internacional de Medicina: Pediaria, Universidad Autonoma de Coahuila, Coahuila, Mexico, March 9, 2005.

“Do you want to be a Genetic Counselor?”, Career Center, Arlington, Virginia, December 7, 2004.

“Jewish Patients and Cancer”, Association for Molecular Pathology, 9th Annual Meeting,Orlando, Florida, November 22, 2003

“The 8.6% of SNPs in Segmental Duplications and Other Tales”, George Mason University, Manassas,

6


Virginia, October 23, 2003

7


“Haplotype Estimation for Disease Association”, NCI-Frederick, Frederick, MD, June 24, 2003.

“Complex Genetics, ER/PR and Breast Cancer”, Celera Diagnostics, Alameda, CA, May 16, 2003,Myriad Genetic Laboratories, Salt Lake City, Utah, July 9, 2003.

“Clinical Molecular Genetics”, LabCorp, Inc.; Research Triangle Park, NC, May 5, 2003.

“Molecular Diagnostics Innovation”, UCLA, Genetics Training Program, Los Angeles, August 13, 2002.

“Molecular Genetics and the Clinic”, Association of Genetic Technologists 27th Annual Meeting, Cincinnati, June 20-23, 2002.

“Counseling Molecular Diagnostics”, as part of the IBC conference: ‘Molecular DiagnosticsMeets Therapeutics’, Boston, June 5-7, 2002.

“Now that you know the rules, what about the exceptions?”, as part of a mini-symposium on Cystic Fibrosis testing at the Annual meeting of the Association for Molecular Pathology, Philadelphia, November 15, 2001. “Genotyping in the Clinic”, Hilton San Diego Resort, as part of Cambridge Healthtech Institute’s conference on Molecular Analysis for Research and Diagnostics, February 15, 2001. “Current Trends in DNA Diagnosis: Targets, Techniques & Instrumentation”, Bio-Rad Laboratories, Diagnostics Group; Hercules, California, February 13, 2001.

“Specific Screening in Specific Spots”, Myriad Genetic Laboratories, Salt Lake City, Utah, January 11, 2000; The Foundation for Blood Research, Scarborough, Maine, February 22, 2000; Frederick Cancer Research Facility, National Cancer Institute-National Institutes of Health, Frederick, Maryland, February 23, 2000; Baylor College of Medicine, February 28, 2000; University of Pittsburgh, March 10, 2000.

“Technology for Human Mutation Testing 1999”, National Society of Genetic Counselors, Annual Education Conference, Oakland, California, October 18, 1999.

“Folic Acid Deficiency, Chromosome Breakage and 5-methylcytosine-DNA-glycosylase”,Norris Cancer Center, University of Southern California, Los Angeles, February 26, 1996.

"The Alu Retroposon, Cancer and Human Mutation", National Cancer Institute,National Institutes of Health, Bethesda, Maryland, June 8, 1993.

"Similarities and Differences Between Maize Transposable Elements and Mammalian SINEs and LINEs", Lawrence Bogorad Symposium, The Biological Laboratories,Harvard University, Cambridge, Massachusetts, May 9, 1993.

"An Omega Vector Based System for Studying Alu-Element Transposition"Department of Biochemistry and Molecular Biology, University of Medicineand Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, February 11, 1993.

"Role of Alu Sequences in Transcription"Coriell Institute for Medical Research, Camden, New Jersey, August 1991

"Sequencing Tricks and RFLP Mapping X Linked Mental Retardation"Biology Department, Rugers University, Camden, New Jersey, November 1990

8


PUBLICATIONS PEER-REVIEWED ARTICLES

Kirchhoff T, Chen Z-q, Gold B, Pal P, Gaudet M, Kosarin K, Levine DA, Gregersen P, Spencer S, Harlan M, Robson M, Klein RJ, Hudis CA, Norton L,Dean M and Offit K (2009) The 6q22.33 Locus and Breast Cancer Susceptibility. Cancer Epidemiology, Biomarkers and Prevention, in the press.

Julg B, Reddy R, vanderStok M, Kulkarni S, Gold B, Qi Y, Nalls MA, Walker BD, Carrington M, Ndungu T (2009) Lack of Duffy Antigen Receptor for Chemokines: No Influence on HIV Disease Progression in an African Treatment Naïve Population. Cell Host & Microbe, 5: 413-5.

Bergeron-Sawitzke J, Gold B, Olsh A, Schlotterbeck S, Lemon K, Visvanathan K, Allikmets R, Dean M (2009) Multilocus Analysis of Age-Related Macular Degeneration, European Journal of Human Genetics, Mar 4. [Epub ahead of print].

Stefanov S, Lautenberger J, and Gold B (2008) An Analysis Pipeline for Genome-wide Association Studies. Cancer Informatics, Cancer Informatics 6, 455–461.

Bacolod MD, Schemmann GS, Wang S, Shattock R, Giardina SF, Zeng Z, Shia J, Stengel RF, Gerry N, Hoh J, Kirchoff T, Gold B, Christman MF, Offit K, Gerald WL, Notterman DA, Ott J, Paty PB, and Barany F (2007) The Signatures of Autozygosity Among Patients with Colorectal Cancer, Cancer Research, 68, 2610-2621.

Gold B, Kirchhoff T, Stefanov S, Lautenberger J, Viale A, Garber J, Friedman E, Narod S, Olshen A, Gregersen P, Kosarin K, Olsh A, Bergeron J, Ellis NA, Klein R, Norton L, Dean M, Boyd K and Offit K (2008) Genome Wide Association Study Provides Evidence of a Breast Cancer Risk Locus at 6q22.33. Proc. Nat. Acad. Sci., USA, 105: 4340-5.

Pujana MA, Han JD, Starita LM, Stevens KN, Tewari M, Ahn JS, Rennert G, Moreno V,Kirchhoff T, Gold B, Assmann V, Elshamy WM, Rual JF, Levine D, Rozek LS, GelmanRS, Gunsalus KC, Greenberg RA, Sobhian B, Bertin N, Venkatesan K,Ayivi-Guedehoussou N, Solé X, Hernández P, Lázaro C, Nathanson KL, Weber BL,Cusick ME, Hill DE, Offit K, Livingston DM, Gruber SB, Parvin JD, Vidal M. (2007) Network modeling links breast cancer susceptibility and centrosome dysfunction. Nat Genet. 39: 1338-1349.

Ogino S, Wilson RB, Gold B and Flodman P (2007) Bayesian Risk Assessment in Genetic Testing for Autosomal Dominant Disorders with Age-Dependent Penetrance J. of Genetic Counseling, 16:29-39.

Nicodemus KK, Law AJ, Luna A, Kolachana BS, Gold B, Rujescu D, Vakkalanka R, Giegling I, Mathew S, Tan H-Y, Hyde T, Callicott JH, Weinberger DR. NRG1 3´ Polymorphisms act in Epistasis with Signaling Partner AKT1, CHRNA7 and CAPON Polymorphisms To Influence Risk of Schizophrenia. Manuscript submitted.

Tan W, Wang Y, Gold B, Dean M, Harrison PJ, Weinberger DR and Law AJ (2007) Full Length Characterization of a novel Neuregulin I variant (Type IV) in the Adult and Fetal Human Brain. J Biol Chem. 282:24343-51.

Olshen, AB, Gold, B, Lohmueller, K, Struewing, JP, Satagopan, J, Eskin, E., Kirchhoff, Lautenberger, JA, Stefanov, SA, Friedman, E., Norton, L., Ellis, N., Viale, A., Borgen, PI, Clark, AG, Offit, K and Boyd, J. (2008) Analysis of Genetic Variation in Ashkenazi Jews by High Density SNP Genotyping. BMC Genetics, 9, 14.

Hageman, GS, Hancox, LS, Taiber, AJ, Gehrs, KM, Anderson, DH, Johnson, LV, Radeke, MJ, Kavanagh, D, Richards, A, Atkinson, J, Meri, S, Bergeron, J., Zernant, J, Merriam, J,

9


Gold, B, Allikmets, R, Dean M. (2007) Extended haplotypes in the complement factor H (CFH) and CFH related (CFHR) family of genes that protect against age-related macular degeneration: Identification, ethnic distribution and evolutionary implications. Ann Med. 2006;38(8):592-604..

10


Li X, Gold B, O'huigin C, Diaz-Griffero F, Song B, Si Z, Li Y, Yuan W, Stremlau M, Mische C, Javanbakht H, Scally M, Winkler C, Dean M, Sodroski J.(2006) Unique features of TRIM5alpha among closely related human TRIM family members. Virology 360:419-33.

Sea Urchin Genome Sequencing Consortium, Sodergren E, Weinstock GM, Davidson EH, Cameron RA, Gibbs RA, Angerer RC, Angerer LM, Arnone MI, Burgess DR, Burke RD,Coffman JA, Dean M, Elphick MR, Ettensohn CA, Foltz KR, Hamdoun A, Hynes RO,Klein WH, Marzluff W, McClay DR, Morris RL, Mushegian A, Rast JP, Smith LC,Thorndyke MC, Vacquier VD, Wessel GM, Wray G, Zhang L, Elsik CG, Ermolaeva O,Hlavina W, Hofmann G, Kitts P, Landrum MJ, Mackey AJ, Maglott D, Panopoulou G,Poustka AJ, Pruitt K, Sapojnikov V, Song X, Souvorov A, Solovyev V, Wei Z,Whittaker CA, Worley K, Durbin KJ, Shen Y, Fedrigo O, Garfield D, Haygood R,Primus A, Satija R, Severson T, Gonzalez-Garay ML, Jackson AR, Milosavljevic A,Tong M, Killian CE, Livingston BT, Wilt FH, Adams N, Bellé R, Carbonneau S,Cheung R, Cormier P, Cosson B, Croce J, Fernandez-Guerra A, Genevière AM, Goel M,Kelkar H, Morales J, Mulner-Lorillon O, Robertson AJ, Goldstone JV, Cole B, Epel D, Gold B, Hahn ME, Howard-Ashby M, Scally M, Stegeman JJ, Allgood EL, Cool J,Judkins KM, McCafferty SS, Musante AM, Obar RA, Rawson AP, Rossetti BJ, GibbonsIR, Hoffman MP, Leone A, Istrail S, Materna SC, Samanta MP, Stolc V, TongprasitW, Tu Q, Bergeron KF, Brandhorst BP, Whittle J, Berney K, Bottjer DJ, CalestaniC, Peterson K, Chow E, Yuan QA, Elhaik E, Graur D, Reese JT, Bosdet I, Heesun S, Marra MA, Schein J, Anderson MK, Brockton V, Buckley KM, Cohen AH, Fugmann SD,Hibino T, Loza-Coll M, Majeske AJ, Messier C, Nair SV, Pancer Z, Terwilliger DP, Agca C, Arboleda E, Chen N, Churcher AM, Hallböök F, Humphrey GW, Idris MM,Kiyama T, Liang S, Mellott D, Mu X, Murray G, Olinski RP, Raible F, Rowe M,Taylor JS, Tessmar-Raible K, Wang D, Wilson KH, Yaguchi S, Gaasterland T, GalindoBE, Gunaratne HJ, Juliano C, Kinukawa M, Moy GW, Neill AT, Nomura M, Raisch M,Reade A, Roux MM, Song JL, Su YH, Townley IK, Voronina E, Wong JL, Amore G,Branno M, Brown ER, Cavalieri V, Duboc V, Duloquin L, Flytzanis C, Gache C,Lapraz F, Lepage T, Locascio A, Martinez P, Matassi G, Matranga V, Range R, RizzoF, Röttinger E, Beane W, Bradham C, Byrum C, Glenn T, Hussain S, Manning G,Miranda E, Thomason R, Walton K, Wikramanayke A, Wu SY, Xu R, Brown CT, Chen L,Gray RF, Lee PY, Nam J, Oliveri P, Smith J, Muzny D, Bell S, Chacko J, Cree A,Curry S, Davis C, Dinh H, Dugan-Rocha S, Fowler J, Gill R, Hamilton C, Hernandez J, Hines S, Hume J, Jackson L, Jolivet A, Kovar C, Lee S, Lewis L, Miner G,Morgan M, Nazareth LV, Okwuonu G, Parker D, Pu LL, Thorn R, Wright R. (2006) The genome of the sea urchin Strongylocentrotus purpuratus. Science 314:941-52.

Javanbakht H, An P, Gold B, Petersen DC, O'Huigin C, Nelson GW, O'Brien SJ, KirkGD, Detels R, Buchbinder S, Donfield S, Shulenin S, Song B, Perron MJ, StremlauM, Sodroski J, Dean M, Winkler C. (2006) Effects of human TRIM5alpha polymorphisms on antiretroviral function and susceptibility to human immunodeficiency virus infection.Virology 354:15-27.

Bacolla A, Collins JR, Gold B, Chuzhanova N, Yi M, Stephens RM, Stefanov S, Olsh A, Jakupciak JP, Dean M, Lempicki RA, Cooper DN and Wells RD (2006) Long homopurine-homopyrimidine sequences are characteristic of genes expressed in brain and the pseudoautosomal region. Nucleic Acids Research, 34:2663-75.

Gold B, Merriam JE, Zernant J, Hancox LS, Taiber AJ, Gehrs K, Cramer K, Neel J, Bergeron J, Barile GR, Smith RT, Hageman GS, Dean M, Allikmets R, Chang S, Yannuzzi LA, Merriam JC, Barbazetto I, Lerner LE, Russell S, Hoballah J, Hageman J, Stockman H. (2006) Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration.Nat Genet. 38:458-62.

11


Petersen DC, Glashoff RH, Shrestha S, Bergeron J, Laten A, Gold B, van Rensburg EJ, Dean M, Hayes VM (2005) Risk for HIV-1 infection associated with a common CXCL12 (SDF1) polymorphism and CXCR4 variation in an African population. J. Acquir Immune Defic Syndr., 40: 521-526.

Hageman GS, Anderson DH, Johnson LV, Hancox LS, Taiber AJ, Hardisty LI, Hageman, JL, Stockman HA, Borchardt JD, Gehrs KM, Smith RJ, Silvestri G, Russell SR, Klaver CC, Barbazetto I, Chang S, Yannuzzi LA, Barile GR, Merriam JC, Smith RT, Olsh AK, Bergeron J, Zernant J, Merriam JE, Gold B, Dean M, Allikmets R (2005) A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci U S A 102:7227-32

Landi MT, Kanetsky PA, Tsang S, Gold B, Munroe D, Rebbeck T, Swoyer J, Ter-Minassian M, Hedayati M, Grossman L, Goldstein AM, Calista D, Pfeiffer RM (2005) MC1R, ASIP, and DNR repair in sporadic and familial melanoma in a Mediterranean population. J Natl Cancer Inst. 97:998-1007.

Ng D, Stavrou T, Liu L, Taylor MD, Gold B, Dean M, Kelley MJ, Dubovsky EC,Vezina G, Nicholson HS, Byrne J, Rutka JT, Hogg D, Reaman GH, Goldstein AM (2005) Retrospective family study of childhood medulloblastoma. Am J Med Genet 134: 399-403. Ogino, S, Flodman, P, Wilson, RB, Gold, B and Grody, W.W. (2005) Risk Calculations for Cystic Fibrosis in Neonatal Screening by Immunoreactive Trypsinogen and CFTR Mutation Tests. Genetics in Medicine, 7:317-27.

Song B, Gold B, O’hUigin C, Javanbakht H, Li X, Stremlau M, Winkler C, Dean M, Sodroski J (2005) The B30.2(SPRY) Domain of the Retroviral Restriction Factor TRIM5 Exhibits Lineage-Specific Length and Sequence Variation in Primates. Journal of Virology 79, 6111-6121.

Gold, B.; Kalush, F.; Bergeron, J.; Scott, K.; Mitra, N.; Wilson, K.; Ellis, N.; Huang, H.; Chen, M.; Lippert, R.; Halldorsson, B.V.; Woodworth, B.; White, T.; Clark, A.G.; Parl, F.F.; Broder, S.; Dean, M. and Offit, K. (2004) Estrogen Receptor Genotypes and Haplotypes Associated with Breast Cancer Risk. Cancer Research 64, 8891-8900.

Ogino S, Wilson RB, Gold B, Hawley P, Grody WW. (2004) Bayesian analysis for cystic fibrosis risks in prenatal and carrier screening. Genetics in Medicine 6, 439-449.

Ogino S, Wilson RB, Gold B. (2004) New insights on the evolution of the SMN1 and SMN2 region: simulation and meta-analysis for allele and haplotype frequency calculations. European Journal of Human Genetics Oct 06, 2004, 1-9.

Yang XR, Wacholder S, Xu Z, Dean M, Clark V, Gold B, Brown LM, Stone BJ, Fraumeni JF Jr, Caporaso NE (2004) CYP1A1 and GSTM1 polymorphisms in relation to lung cancer risk in Chinese women. Cancer Letters 214, 197-204.

Collins, J.R.; Stephens, R.M.; Gold, B.; Long, B.; Dean, M. and Burt, S.K. (2003) An Exhaustive DNA Micro-Satellite Map of the Human Genome Using High Performance Computing. Genomics 82, 10-9.

Gold, B. (2003) Origin and Utility of the Reverse Dot Blot. Expert Review of Molecular Diagnostics 3, 89-98.

Egan, M.F.; Callicot, J.H.; Goldberg, T.E.; Kolachana, B.S.; Bertolino, A.; Goldman, D.;Gold, B., Dean, M.; Lu, B.; and Weinberger, D. (2003) BDNF Val66 Met polymorphism affects vesicular packaging and human hippocampal function. Cell 112, 257-269.

12


Lappin, S.; Cahlik, J. and Gold, B. (2001) Robot Printing of Reverse Dot Blot Arrays for Human Mutation Detection. Journal of Molecular Diagnostics, 3, 178-188.

Gold, B.; Bergeron, J.; Lachtermacher-Triunfol, M. and Dean, M. (2001) Human Duplex Sex Determination PCR. Biotechniques, 31; 28-33.

Gold, B; DNA Genotyping (2001) Advances in Clinical Chemistry, 36, 171-234.

Gold, B.; Hanson, M.; and Dean M. (2001) Two Rare Confounding Polymorphisms Proximal to the Factor V Leiden Mutation. Molecular Diagnosis, 6, 137-140.

Arnould, I.; Schriml, L.; Prades, C.; Lachetermacher-Tiunfol, Schneider, T.; Maintoux, C.; Lemoine, C.; Debono, D.; Devaud, C.; Naudin, L.; Bauche, S.; Annat, M.; Annilo, T., Allikmets, R.; Gold, B.; Denefle, P.; Rosier, M.; and Dean, M. (2001) Identifying and Characterizing a five-gene cluster of ATP-Binding Cassette transporters mapping to human chromosome 1q24: A new Sub-group within the ABCA sub-family. GeneScreen 1, 157-164. Gold, B.; Radu, D.; Balanko, A. and Chiang, C-S. (2000). Diagnosis of Fragile X Syndrome by Southern Blot Hybridization Using a Chemiluminescent Probe: A laboratory protocol. Molecular Diagnosis, 5, 169-178.

Kowalski, A.; Radu, D. and Gold, B. (2000). Colorimetric Microwell Plate Detection of the Factor V Leiden Mutation. Clinical Chemistry, 46, 1195-1198

Amos, J. and Gold, B. (1998) Testing Environment for Single-Gene Disorders in U.S. Reference Laboratories. Human Mutation 12, 293-300.

Zhang, R-D, Guan, M.; Park, Y.; Tawadros, R., Yang, J-Y, Gold, B., Wu, B. and Henderson, E.E. Effect of Epstein-Barr Virus on HIV-1 Expression in T Cell Lines and CD4-Positive and CD8-Positive Lymphocytes. (1997) AIDS Research and Human Retroviruses, 13, 161-171.

Lazzarini, A.; Stenroos, E.S.; Lehner, T.; McKoy, V.; Gold, B.; McCormack, M.K.; Reid, C.S.; Ott, J. and Johnson, W.G. (1995) Short Tandem Repeat Polymorphism Studies in a New Family With X Linked Mental Retardation (MRX 20). American Journal of Medical Genetics, 57, 552-557.

Gold, B. and McCormack, M.K. (1993) FORTRAN Program Interpretation of the Triple Screen Prenatal Blood Test. Biotechnology Software, September-October 1993, 17-23,30.

Gold, B.; Carrillo, N.; Tewari, K.K. and Bogorad, L. B. (1987) Nucleotide Sequence of a Preferred Maize Chloroplast Genome Template for in vitro DNA Synthesis. Proceedings of the National Academy of the Sciences, USA, 84, 194-198.

Gold, B.; Fujimoto, H.; Kramer, J.M.; Erickson, R.P.; and Hecht, N.B. (1983) Haploid Accumulation and Translational Control of Phosphoglycerate Kinase-2 Messenger RNA During Mouse Spermatogenesis. Developmental Biology 98, 392-399.

13


Stern, L.; Kleene, K.C.; Gold, B. and Hecht, N.B. (1983) Gene Expression During Mammalian Spermatogenesis III. Changes in Populations of mRNA During Spermatogenesis. Experimental Cell Research 143, 247-255.

Gold, B.; Stern, L.; Bradley, F.M.; and Hecht, N.B. (1983) Gene Expression During Mammalian Spermatogenesis II. Evidence for Stage-Specific Differences in mRNA Populations. Journal of Experimental Zoology 225, 123-134.

Stern, L.; Gold, B. and Hecht, N.B. (1983) Gene Expression During Mammalian Spermatogenesis I. Evidence for Stage-Specific Differences in mRNA Polypeptides In Vivo. Biology of Reproduction 28, 483-496.

Abstracts, Book Chapters, and Non-refereed Publications

Comen E, Lautenberger J, McGee K, Kirchoff T, Dean M, Hudis C, Norton L, Offit K, Gold B, Robson M (2009) High-density genotyping of women with breast cancer suggests common germline variants may be associated with recurrence. ASCO 2009.

Gold, B. (2009) Automated DNA Hybridization and Detection, Chapter 40, in Molecular Diagnostics, 2nd Edition Drs George Patrinos and Wilhelm Ansorge, eds., Academic Press.

Gold B and Dean M (2009) Breast Cancer Stem Cells, in "Stem Cells and Cancer", Sadhan Majumder, ed., Springer Science, NY.

Offit, K., Olshen, A., Gold, B., Struewing, J., Satagopan, J., Eskin, E., Kirchhoff, T., Lautenberger, J.A., Stefanov, S., Goldgar, D., Friedman, E., Norton, Ellis, N., Viale, Borgen, P., Lohmueller, K., Clark, A., and Boyd, J. (2006) High Density SNP Analysis of Ashkenazi Jews. Abstracts from the 56th Annual Meeting of the American Society of Human Genetics, 992/A at page 195.

Stefanov, S., Lautenberger, J., Dean, M. and Gold, B. (2006) An Analysis Pipeline for Large SNP Genotype Scans. . Abstracts from the 56th Annual Meeting of the American Society of Human Genetics, 2286/B at page 415.

Gold, B. (2006) Reversed Line Blot Hybridization in the Encyclopedia of Diagnostic Genomics and Proteomics. Drs. Jürgen Fuchs, Maurizio Podda, eds. Taylor and Francis.

Gold, B. (2005) Automated DNA Hybridization and Detection, Chapter 25, in Molecular Diagnostics,Drs George Patrinos and Wilhelm Ansorge, eds., Academic Press.

Dean M, Gold B, Van Ness J, Galas DJ (2003) Surveying genomic deletions and duplications through the generation of oligonucleotide fingerprints using primer-free amplification. American Journal of Human Genetics 73 (5): 1455 November 2003.

Lee JA, Dean M, Gold B, Lupski JR, Inoue K (2003) Genomic architecture involved in PLP1 duplication causing Pelizaeus-Merzbacher disease. American Journal of Human Genetics 73 (5): 1562 November 2003.

Yang XH, Wacholder S, Zu ZY, Dean M, Clark V, Gold B, Brown LM, Stone BJ, Caporaso N (2002) CYP1A1 and other single nucleotide polymorphisms in relation to lung cancer risk: A case-control study of women in north-east China. Cancer Epidemiology Biomarkers & Prevention 11 (10): D208 part 2 October2002.

14


Gold, B. (2002) Towards a reconciliation between molecular diagnostics and new pharmaceuticals. Drug Discovery Today 7, 1034-1035.

15


Potocnik, U.; Martin, M.P.; Gold, B.; Gao, X.; Dean, M. and Carrington, M. (2002) Genetic Risk Factors For Progression to Lymphoma in AIDS Patients. American Journal of Human Genetics Vol. 71 Supplement, p. 250, #458.

Gold, B. (2002) Counseling Molecular Diagnostics. Drug Discovery Today, 7, 687-689.

Gold, B. (2002) Semi-automated Cystic Fibrosis Carrier Testing. LabMedica International, 19, No. 5-6, 6-7.

Chen, M.; Robert, A.; Dean, M. and Gold, B. (2001) Mix Formulations and Alternative Probe Backbones for TaqMan Allele Discrimination Assays. Journal of Molecular Diagnostics, 3, 196, G26.

Gold, B. (2001) Molecular Recipes, A book review of Molecular Pathology Protocols, Anthony A. Killeen ed., Current Microbiology, 43, 378-379.

Gold, B. Hanson, M and Dean, M. (2000) Two New Rare Polymorphisms in the Factor V Leiden Gene.

Journal of Molecular Diagnostics, 2, 221, G10.

Gold, B. (1999) Molecular Genetic Diagnostics, ADVANCE for Medical Laboratory Professionals, 11, No. 25 18-21.

Kowalski, A.J. and Gold, B. (1998) Colorimetric microwell plate detection of the factor V (R506Q) mutation. American Journal of Pathology, 153, 1648,G3.

Radu, D.and Gold, B. (1998) Colorimetric detection of hereditary hemochromatosis C282Y and H63D mutations. Clinical Chemistry, 44, No. 6, supplement.

Lappin, S.; Novak, J.; Rabin, M.; Cahlik, J. and Gold, B. (1998) Automated printing of reverse dotblot arrays for the detection of human b-globin mutations. Clinical Chemistry, 44, No. 6, supplement.

Kowalski, A.J.; Gold, B. and Chiang, C.S. (1998) Optimization of a Super Sensitive HIV-1 RNA (Quantitation) PCR Assay. Abstracts from the 98th General Meeting of the American Society for Microbiology, T-2.

Norman, J. Shahar, Y. Kuppermann, M. & Gold, B. (1998) Decision-Theoretic Analysis of Prenatal Testing Strategies. 1998. SMI-98-0711. http://www-smi.stanford.edu/pubs/SMI_Reports/SMI-98-0711.pdf

Gold, B. (1996) HLA Typing and a Young Girl's Death (Letter). MT Today, May 13, 1996.

Gold, B. (1996) Trying to Think Like Tom Swift about SMA [Spinal Muscular Atrophy] (Essay). Living SMArt, February-March, 1996, pp. 4-5.

Thakur, A.; Gold, B.; Vairapandi, M.; Duker, N.J.; Paraskeva, C. and Yunis, J.J. (1995)Effects of folic acid deficiency on excision of 5-methylcytosine from DNA. The FASEB Journal, 9, A139.

Thompson, W.E.; Spangenberg, D.B.; Stein, T.P. and Gold, B. (1993) The three majormuscle groups are composed of three myofibril types in the jellyfish, Aurelia aurita.Molecular Biology of the Cell 4, #221.

Gold, B. (1992) Book Review of Muscular Dystrophy and Other Neuromuscular Diseases:Psychosocial Issues by Leon Charash et al., Social Work in Health Care, 18, 121-123.

16


Thompson, W.E. ; Gold, B.; Spangenberg, D.B. and Stein, T.P. (1991) Monospecific AntibodyAgainst Chicken Skeletal Actin Does Not Recognize Actin in Jellyfish, Aurelia aurita.Journal of Cell Biology, 115, # 942.

Gold, B. (1991) What is the role of the Alu retrotransposon in transcription and splicing?Journal of Cell Biology, 115, # 1772.

Gold, B.; Lazzarini, A.; and McCormack, M. (1991) Familial X-Linked Mental Retardation(XLMR) Correlates with a RFLP Proximal to Fragile X. Miami Short Reports 1, 9.

Lazzarini, A.; Gold, B. and McCormack, M. (1990) Cytogenetic and RFLP analysis in sex-linked mental retardation. Am. J. Hum. Genet. 47, A188.

Buchanan-Wollaston, B.; Gold, B.; Naser, A. and Cannon, F. (1989) Detoxification of theherbicide Dalapon by transformed plants. Journal of Cellular Biochemistry Supplement, n. 13,Part D, 330.

Gold, B. Rapid, Large Scale Plasmid Preparation. BMBiochemica 1, 6. (Available from Boehringer Mannheim, Inc.)

Stern, L.; Gold, B. and Hecht, N.B. (1982) Synthesis of Stage Specific Protein Markers inPachytene Primary Spermatocytes and Round Spermatids from Murine Testis. Journal of Andrology 3, 28-29.

Gold, B.; Stern, L.; and Hecht, N.B. (1981) Stage Specific Differences in thePolypeptides Encoded by Messenger RNA Populations During Spermatogenesis in theMouse. Journal of Cell Biology 91, # 188a.

17


Professional Memberships American College of Medical Genetics

References

Jean Amos Wilson, PhD Vice President, Laboratory Operations Berkeley HeartLab, Inc. 960 Atlantic Ave Suite 100 Alameda, CA 94501-1086 510-263-4008 VOICE510-508-3802 CELL510-521-5039 [email protected]

C.S. Chiang, Ph.D. Head of DiagnosticsMannkind Corp. Inc.28903 North Avenue PaineValencia, CA 91355. 661-775-5558 VOICEEMAIL: [email protected] Research Supervisor at SmithKline Beecham Clinical Labs./Quest DiagnosticsNon-Collaborator

Hon Fong L. Mark, Ph.D.,M.B.A.,F.A.C.M.G.Director, Cytogenetics Laboratory Center for Human GeneticsClinical Professor of Pathology & Laboratory MedicineBoston University School of Medicine700 Albany StreetBoston, MA 02118Phone: 617-638-7097E-mail: [email protected] ColleagueNon-Collaborator

Wayne Grody, M.D., Ph.D.Professor of Pathology and Lab. MedicineUCLA Box 951732, IP-249 CHSLos Angeles 90095-1732310-825-5648 [email protected] ColleagueCollaborator

18


Other Qualifications

Ad Hoc Reviewer for:AIDSAmerican Journal of HypertensionBiotechniquesBMC BioinformaticsGenome BiologyHuman MutationHuman GenomicsImmunogeneticsJournal of HeredityJournal of Molecular DiagnosticsMayo Clinic ProceedingsMutation ResearchNatureNucleic Acids ResearchProceedings of the National Academy of the Sciences, USA

Reviewer also for:Intel Science Talent SearchIsrael Cancer Research Fund, Scientific Review BoardGenetics and Genomics Study SectionNational Institute for Research Resources

Invited to lecture on Medical Genetic Topicsin Chile (2001), Mexico (2004), Italy (2007) andthroughout the United States 2000-present.

Revised August 2, 2009

19

bert's february 2009 cv

Documents

salt lake city

bronze impact award

folic acid deficiency

related macular degeneration

linked mental retardation

roche diagnostic systems

56th annual meeting

high performance computing