beta lactam plus aminoglicoside sinergy
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penelitian mengenai sinergi goglongan antibiotik betalaktam dan aminoglikoside, ternyata efektifitasnya lebih dibandingkan beta laktam sajaTRANSCRIPT
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Rev Infect Dis. 1982 MarApr;4(2):23745.
Bactericidal synergism between betalactams andaminoglycosides: mechanism and possible therapeuticimplications.Davis BD.
AbstractThis work, presented as the introductory lecture of the symposium, reviews themechanisms of antibiotic action of betalactams and of aminoglycosides from ahistorical perspective and gives emphasis to the features relevant to theirsynergistic interaction. These features include the limiting effect of penetration ofaminoglycosides on the rate of killing; the ability of betalactams to increase thatpenetration, even under conditions where they cannot cause a lethal damage tothe cell envelope; and the ability of aminoglycosides to be lethal with a smalleramount of cell growth than is required for killing by betalactams. The paper alsobriefly discusses theoretical arguments favoring a broader use of bactericidalsynergism in clinical practice.
PMID: 7051225 [PubMed indexed for MEDLINE]
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