Proline-bulky AA due to cyclic structure

H bonds maintain spiral

Alpha helix-soluble structure

Marfan syndrome-helical fibrilin, long extremities

Quaternary- joined together by non-covalent bonds

Prion diseases-dr. oclarit (tomorrow!!)

Between H and O- hydrogen bond

SS bond-disulfide

HSPs –protiens resistant to drastic change in pH

Urea-breaks hydrogen bonds

Histones-protiens that associate with DNA

RAS-tumor marker

Transcription-DNA to RNA

Degradation happens when they are not properly folded

Bortezomib-drug fighting cancer cells

Cancer-dependent on protein somal degradation

Sickle cell anemia-point mutation, change in codon 6

Sickling-low O2

Quaternary- sigmoidal (hemoglobin)

Myoglobin-better oxygen binder

P50-pressure at which… is saturated with O2

Vit C-provides hydroxyl