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TURNKEY SERVICES one-stop shop preclinical imaging molecular imaging A n t o n i o 1 7 M a y 0 9

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Biodata presentation company 2-3 of february 2010

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TURNKEY SERVICESone-stop shop

preclinical imagingmolecular imaging

Antonio 17M

ay09

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EXECUTIVE SUMMARY

Animascope is an R&D contract services company specialised in multi-modality non-invasive biomedical imaging for discovery

and preclinical exploratory research

in several therapeutic areas

Non-invasive imaging allows the in vivo visualisation of structures, functions and dysfunctions, whole-body

In vivo imaging is a cost-effective and time-effective approach to streamline discovery and preclinical studies and increase

predictability of clinical outcomes

Reduce experimental artifacts, Refine your animal models, Reduce the animal usage from 100% down to 20-30%

Be earlier in the market !

Antonio 17M

ay09

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Competitive advantages– Reduction of the operating time. – Reduction of the number of animals – Longitudinal follow up. – Translation to human. – Gateway mandatory in various stages of

drug development – A future technology can replace

histological analysis

From technology push to Market drive

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IMAGING IN DRUG DISCOVERY AND DEVELOPMENT

Antonio 17M

ay09

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Ultrason HR(High Résolution)

Ultrason HR(High Résolution)

µPET(Positrons Emission

Tomography)

µPET(Positrons Emission

Tomography)µMRIµMRI

µScanner XµScanner XOpticalBioluminescence

& fluorescence

OpticalBioluminescence

& fluorescence

Nano SPECTSingle photon emission computed tomography

Nano SPECTSingle photon emission computed tomography

ANIMASCOPE proposes small animal imaging services via six modalities.

MULTI-MODALITY IMAGING

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MRI

US

Opt.

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INDUSTRY SEGMENTS

Imaging is utilized in many industry segments

RED BIOTECHNOLOGY BIOLOGICS, BIOPHARMACEUTICALS Nanotechnology Nutraceuticals, Functional food, dietary supplements Agrichemicals, Phytopharmaceuticals Environment and Chemistry (risk assessment) Biomaterials, Material sciences (non-biomedical) A

ntonio 17May09

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TURNKEY SERVICESOur turnkey services are based on integrated multi-disciplinary skills. Customisable services and full studies are available depending on customer needs. Every project is tailored to optimize outcomes and readouts

PROTOCOL DESIGNDefinition of biological parameters to be measuredChoice of imaging modalities, contrast agents, tracers, biomarkersDesign of image processing workflow

STUDY MANAGEMENTPre-conditioning of selected modelsImage acquisitionRecording and traceability

IMAGE PROCESSINGImage handling and pre-processingData analysis

REPORTINGTechnical reportingBiomedical reporting

Antonio 17M

ay09

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ONE-STOP SHOP SERVICES

We are committed to offer a global range of preclinical imaging services to our customers. Additional services are:

ANIMAL MODEL SELECTION AND SOURCING PRE-CONDITIONING OF ANIMAL MODELS SOFTWARE DEVELOPMENT CONSULTANCY TRAINING

Antonio 17M

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ANIMASCOPE EXPERTISE

Animascope has gathered the best expert capabilities to meet your experimental needs. Complementarity of competences and MULTIDISCIPLINARY EXPERTISE are core imperatives at Animascope

Medical Imaging, nuclear medicine, multi-modality animal imaging, image processing, animal models, animal experimentation, experimental oncology, pharmacology, business management of biomedical services

Stéphane LAMBERT Daniel CHRISTIAEN Mimoun NEJJARI Bassem HIBA Antonio SERVADIO

Antonio 17M

ay09

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ADVISORY BOARDSENIOR ADVISORS

Françoise BORSON CHAZOT

Head of the Nuclear Medicine Unit, Hospital Neuro-Cardiologique, Lyon

Jacques DEMONGEOT

Specialist of Medical Informatics, Biomatematics and Cognition Modeling, Grenoble

Jacques DESCOTES

Head of the Poison Control and Toxicovigilance Centre, Lyon

Georges HAOUR

Prof. of Technology & Innovation Management at IMD, Basel

Patrick HARDY

Director of Animal Science & Welfare at Merial R&D, Lyon

Marc JANIER

Head of the Clinical Unit of Nuclear Medicine at the Edouard Herriot Hospital, Lyon

Founder of Animage in Lyon

Osman RATIB

Head of the Clinical Unit of Nuclear Medicine at the Univ. Hospital, Geneva

Mohamed SLAOUI Senior Toxicoloic Pathologist at Sanofi-Aventis (Paris)

Antonio 17M

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Vertical Intégration =Machines = Number & Modalities

Horizontal Integration =

Thematic Expertise, animal models, Equipment, tracers, software, clinical translation

Bioscan

Business Model

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•Consolidationthrough buying out

•New sites, •New machines

•New skills•New capabilities

Sales

Academic Platform Animascope

2003 2009 2011

800 K€

5 M€

25 M€

Competitive advantageCompetitive advantage

•First in time experience •Already sales•Technical experience•Multimodality•EU research networks

Capitalized experienceCapitalized experience

•Startup Private company•Commercial achievments•Marketing partnerships

Levrage DevelopmentLevrage Development

Development model

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ZA EUREKALP38660 St. Vincent de Mercuze (Grenoble), FranceTel: +33 (0)4 76979487 www.animascope.euFax: +33 (0)9 55753911 [email protected]

Antonio SERVADIO, BDO [email protected] CHRISTIAEN, CEO [email protected]

ANIMASCOPE CONTACTS

Current Animascope office located in Eurekalp (Near Grenoble)

Main imaging facilityArchamps (near Geneva)

Antonio 17M

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NOW IMAGINE YOUR PHENOTYPE

Antonio 17M

ay09