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WELCOME

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Guided by, Presented By, Mrs. ABHILA.R.KRISHNA SIVAJITH.S ASST. PROFESSOR EC-B,S7 ECE DEPARTMENT ROLL NO:30 TKMIT TKMIT

BIOENGINEERED NANOROBOTICS FOR CANCER THERAPY

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OVERVIEW Introduction Nanorobots Nanorobot Core Power Supply Propulsion Sensing and Actuation Control and Decision Making Integration Advantages Disadvantages Application Conclusion

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IntroductionCancer

Uncontrolled Growth Of CellsSpread all over the body It Cause death

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Treatment

Kills Healthy CellsFatigueHair Loss

Side Effects

Radiation Therapy Chemotherapy

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NanoRobotsThe technology of creating machines or robots

at or close to the microscopic scale of a nanometer (10−9 meters).

Nanorobots are devices made from DNA that are so small they can be injected into the bloodstream and carry a payload of drugs to specific cells.

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Cure Using Nanorobots

Inject nanorobots into patient

Detect cancer Cells Destroy Cells Do not affect on

Healthy Cells

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Contd. Nano Infinitesimally Small Scale of Manufacturing And Fabricating Materials

NanoRobot Tiny machine Perform specific task

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Nanorobot CoreThe core is a polysaccharide-based nanoparticle or cyclic

peptide nanotubeCyclic peptide has ability to self-assemble into

monodisperse nanotubes, are well suited to the coreCapable of carrying a payloadAllow the incorporation of propulsive, sensing and

actuating componentsFloat freely inside the bodyDetect the tumor effectively

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Core of Nanorobots

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Cant use conventional sources ATP released from core Production of heat in the human body Inclusion of electrodes in nanorobots and

electrolytes in human blood will act as battery Combination of chemical reactions in human

blood and chemicals in nanorobots will lead to the formation of fuel source

Power Supply

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Propulsion

Fully functional flagella isolated from E.coliArtificial bacterial flagella(ABF) to move in 3DABF are often fabricated from helical nanobelts with soft

magnetic heads composed of Cr/Ni/AuIt has ability to drive the nanorobots into the tumor tissue

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Sensing and Actuation Capable of sensing and recognizing the targeted

cancer cellsChemical sensors which detect the target moleculesAptamers (derived from the latin aptus, meaning to

fit) are artificial nucleic acid (DNA or RNA) Biomarkers can be specific cells, molecules, or genes,

gene products, enzymes, or hormones.

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Schematic of the cyclic peptide nanorobot core with the aptamers designed for closing and locking the nanotube.

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Aptamer-target interaction

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Control and Decision Making

Use directional control, which is necessary for tumor targeting

Phototactic control to direct the nanorobot to the tumor location

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Integration

First step is fabrication of power supply(ATP containing nanoparticle)

Second step is load the power supply into the coreFinal step is attachment of propulsion system to the

core

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Nanorobots can be used in blood cell to detect pathogens.

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AdvantagesSmall SizeInexpensive(if mass produced)No maintenanceAutomatedPainless TreatmentEasily DisposableAffect only cancer cellsRapid elimination of disease.

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Disadvantage

Initial Design Cost highVery complicate design

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Applications

Breaking up blood clots Fighting cancer Parasite Removal Breaking up kidney stones

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ConclusionWith the introduction of nanorobots, humans can

overcome many type of diseases

It can also helpful in the detection of diseases

Decision making nanorobots are the future of nanorobotic technology

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References R. Baum, “Nanotechnology: Drexler and Smalley make the case for

and against ‘molecular assemblers’,” Chem. Eng. News, vol. 81, pp. 37–42, 2003.

M. Sitti, “Microscale and nanoscale robotics systems [grand challenges of robotics],” IEEE Robot. Autom. Mag., vol. 14, no. 1, pp. 53–60, Mar. 2007.

https://en.wikipedia.org/wiki/Nanorobotics http://hansmalab.physics.ucsb.edu/phys150/nanotech.pdf http://nano-bio.ehu.es/files/nanorobots_work.pdf http://www.roboticsbible.com/power-sources-of-nanorobots.html http://icmr.nic.in/ijmr/2010/august/0803.pdf

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Thank You