Gustavo Adolfo Castilla Agudelo

Medicine student

Universidad Pontificia Bolivariana

2012

FOLDING

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INTRODUCTION

Key Protein May Give Ebola Virus Its

OpeningThe New York Times

(JAN. 16, 2012)

Key Protein May Give Ebola Virus Its OpeningThe New York Times (JAN. 16, 2012)

Taken from: http://www.elmundo.es/elmundosalud/2007/08/31/medicina/1188572400.html

• Ebola is a deadly virus, patients develop fever, fatigue, seizures, delirium, and bleeding.

• Some investigations relate the way of Ebola infection with the NPC1 protein that is found within of the endosome.

Key Protein May Give Ebola Virus Its OpeningThe New York Times (JAN. 16, 2012)

• People without NPC1 protein: the lipids build up in the liver, spleen and brain, this disease is called Niemann-Pick.

• Cells without NPC1 protein are resistant to Ebola.

Taken from: http://www.jopasi.org/anatomia2.php

Key Protein May Give Ebola Virus Its OpeningThe New York Times (JAN. 16, 2012)

• Small molecules that interfere with NPC1 protein might help to ward off an infection of Ebola or make it less severe.

• NPC1 protein is the most convincing target scientifics have seen yet for Ebola

Taken from: http://es.wikipedia.org

OBSERVATION

Taken from: ttp://lanieve2.blogspot.com/2011/05/arreglar-el-mundo.html

I think we must investigate more about this kind of diseases in a molecular

level, because they have a high mortality and may occasions epidemics.

If we get a cure is possible to prevent many deaths.

I think we must investigate more about this kind of diseases in a molecular

level, because they have a high mortality and may occasions epidemics.

If we get a cure is possible to prevent many deaths.

New Clues to Human Deafness

Found in MiceScienceDaily (JAN. 3, 2012)

New Clues to Human Deafness Found in MiceScienceDaily (JAN. 3, 2012)

Close-up view of a normal mouse cochlea (left) and one missing FGF20 (right), showing gaps in sensory hair cells.

• Researchers have identified a gene called FGF20 that is required for a proper development of mouse inner ear.

• When the researchers inactivated FGF20 in mice, they saw they hadn't the ability to hear.

New Clues to Human Deafness Found in MiceScienceDaily (JAN. 3, 2012)

• The results show that disabling the gene causes a loss about 2/3 of outer hair cells.

• This is the first evidence that inner and outer hair cells develop independently one of the other.

Taken from: http://www.hhmi.org/senses-esp/c120.html

New Clues to Human Deafness Found in MiceScienceDaily (JAN. 3, 2012)

Taken from: http://ilevolucionista.blogspot.com/2009/03/genetica-humana-entrevista-luca-cavalli.html

• Scientist found that FGF20 signaling must occur on or before day 14 of the embryo's development to produce a normal inner ear.

• Researchers found evidence that mutations in FGF20 may play a role in human deafness.

OBSERVATION

Taken from: http://www.ciber-arte.com/arte/index.htm

Investigate about genetic mutations that cause disease is very important for the biology, so I think that every

day is necessary depth on these topics with to find a proper and

ethical way to solve these problems.

Investigate about genetic mutations that cause disease is very important for the biology, so I think that every

day is necessary depth on these topics with to find a proper and

ethical way to solve these problems.

MEDICAL UTILITY

MEDICAL UTILITY

Taken from: http://portal.uniquindio.edu.co/noticias/?m=201007&paged=3

The investigations in experimental models are important because it allows medical advances and new discoveries in favor of human health.

MEDICAL UTILITY

Taken from: http://www.conciencianews.com/index.cfm?p=articulos&id=45

Is important to use all our resources, such as experimental models in order to find the cure for all diseases, bearing in mind human life and proper management to organisms used for investigation.

MEDICAL UTILITY

Taken from: http://www.elconfidencial.com/salud/2011/enfermedades-raras-geneticas-abogan-seleccion-genetica-20110301.html

These investigations are essential to obtain further solutions in the field of human health, in this case the most age-related and noise-induced hearing loss is due to the miss of outer hair cells. If we can find ways to regenerate these cells could solve one of the problems that affect our sense of hearing.

BIBLIOGRAPHY

• Martínez Sánchez LM, Vargas Grisales N, Toro Montoya AE, Pamplona Sierra AP, Quevedo Orrego E. Biología molecular. 6. ed. Medellín: UPB. Fac. de Medicina; 2011.

• Huh SH, Jones J, Warchol ME, Ornitz DM. New Clues to Human Deafness Found in Mice. ScienceDaily.  2012; 10 (1)

• Chandran K, Cunningham J,  Dye J. Key Protein May Give Ebola Virus Its Opening. The New York Times. 2012

THANK YOU