biotic games: interactive microbiology - ingmar riedel-kruse, stanford engineering

Biotic Games Interactive micro-biology for

Research, Education,

and Entertainment

Ingmar Riedel-Kruse

STANFORD BIOENGINEERING Riedel-Kruse Lab [email protected]

Engineering and games

? 2


Questions

3 STANFORD BIOENGINEERING Riedel-Kruse Lab [email protected]

1.  Can we bioengineer games? 2.  What are these games like? 3.  What are these games good for?

Games


5

What are games?

•  “structured play” •  goals •  rules •  challenges •  interaction


6

Utility of games •  (“Just”) Entertainment

Fitness Education Rehabilitation

•  Engaging / addictive -> coupling to secondary purpose (“serious games” – C. Abt. 1970)

Activism New technology …??? 6


Bioengineering


What is bioengineering?


•  Biology as an engineering substrate

•  Fusion of engineering and the life sciences

•  Technology invention •  Scientific discovery

•  Applications in medicine, food, energy, environment …

Future Stanford bioengineering building

10

Stanford bioengineering


Human Biomechanics Scott Delp

Micro-fluidics – Steve Quake; Bubble logic - Manu Prakash

Optogenetics Karl Deisseroth

RNA logic gates Christina Smolke

~500 um

11

Electrical vs. biological engineering

Electronic circuit ~1950’s

Micro-fluidic circuit ~2002


Transistor 1947

Micro-fluidic valve ~2000

Table Tennis 2006; Xbox 360

?

“Tennis for two” 1958

Bioengineered games


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Bioengineered games


(i)  Human interaction with biological material or processes (ii)  Enabled by modern biotechnology

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“Biotic games”


(i)  Human interaction with biological material or processes (ii)  Enabled by modern biotechnology

Paramecia and random walks

1

567

8

9 43 2

0.5 sec

0.5 mm

50 um

STANFORD BIOENGINEERING Riedel-Kruse Lab [email protected] 15

Action games with paramecia


Biotic game set-up

Biotic processor

Game controller Fluid chamber


Pinball


Pinball vs. “Biotic Pinball”

1 mm / real time


First publication on biotic games


Comments on the web • useless.invention.ever • Incredible!

• Are paramecia hurt? Unethical to play with life! • It is more benign than picking a flower

• Cure cancer first!

• If they had Playstation in WW2, that is what the controller probably would look like.

• I really like Stanford having such multidisciplinary research opportunities.


Utility of future biotic games

1.  Education 2.  Large scale citizen science 3.  Technology driver 4.  …


Biotic games in education


First test with children in museum


Daniel Schwartz Prof. School of Education, Stanford

Computer games for education

First children test in museum


•  ~40 children ~10 years old •  enjoyed direct visual through scope •  biotic game was too difficult to play •  hardly realized that they played with real paramecia •  no ethical concerns raised

-> different perceptions by age -> implications for improved design

Games for research


Biomedical Experiments Operated by Online Gaming Community

Biotic games for large scale science (citizen science / crowdsourcing / human computation)


Citizen science game: Beans


How many beans are in the jar?

Rules:

•  Don’t talk •  Write down your guess •  Write down your name (other ID)

•  Best guess wins

•  Exchange guess with a stranger

•  Let’s vote!

Rhiju Das Assist. Prof. Biochemistry, Stanford

RNA folding

Adrien Trieulle Assist. Prof. Computer Science /

Robotics; Carnegie Mellon Computer graphics

Biotic games for large scale science

~10.000 players Experimental feedback Once per week for 8 players


RNA and folding A G U C A G C A G C C G A A A

A G U

C A

G

C A

G

C C

G A A

A

Folding problem

Sequence problem

A

A

Eterna : Demonstra-on

http://eterna.cmu.edu/game.php?myType=PUZZLE&myVal=13399

More complex puzzles

Game

Experiment Verifica-on

Loop of global scale game playing and experimental trial & error

EteRNA

EteR

NA

scor

e

Time

EteR

NA

scor

e

EteR

NA

scor

e Human

Computer

Games as technological driver


Games as technological driver (development of new technology and/or cost reductions)

Jen-Hsun Huang (EE MS ’92 Stanford)

3D video game graphics


$

Graphics Processing Unit (GPU) Molecular dynamic simulations

"Jen-Hsun Huang School of Engineering Center."


Jen-Hsun Huang (EE MS ’92 Stanford)

3D video game graphics


$

Graphics Processing Unit (GPU) Molecular dynamic simulations

"Jen-Hsun Huang School of Engineering Center."

Without video games

No deans office

Hongying Zhu et al. LOC 2010

Could biotic games lower costs for mobile diagnostics? 43



3rd world mobile phone based diagnostics

Integrating micro-fluidic chips into phones?

Outlook


45

Electrical vs. biological engineering

Electronic circuit ~1950’s

Micro-fluidic circuit ~2002


Transistor 1947

Micro-fluidic valve ~2000

Table Tennis 2006; Xbox 360

???

“Tennis for two” 1958

Biotic games ~2010

Stanford Bio.X games initiative!(Founded ~Spring 2010; Bio-X IIP seed-funding ~Fall 2010)!

Rhiju Das (Asst Prof Biochemistry, Physics)

Biotic Games

Ingmar Riedel-Kruse (Asst Prof Bioengineering)

Educational video games

Daniel Schwartz (Prof Education)

Objectives: 1.  Develop and build biotic games 2.  Use biotic games to solve educational and scientific challenges 3.  Nucleate a world-wide biotic games community

47

Summary Biotic Games

•  Human player interacting with real biology (experiments)

•  Novel features •  Educational value •  Citizen science •  Technology driver •  …

•  Stanford Bio.X games center
