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Biotic Games Interactive micro-biology for
Research, Education,
and Entertainment
Ingmar Riedel-Kruse
STANFORD BIOENGINEERING Riedel-Kruse Lab [email protected]
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Questions
3 STANFORD BIOENGINEERING Riedel-Kruse Lab [email protected]
1. Can we bioengineer games? 2. What are these games like? 3. What are these games good for?
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What are games?
• “structured play” • goals • rules • challenges • interaction
5 STANFORD BIOENGINEERING Riedel-Kruse Lab [email protected]
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Utility of games • (“Just”) Entertainment
Fitness Education Rehabilitation
• Engaging / addictive -> coupling to secondary purpose (“serious games” – C. Abt. 1970)
Activism New technology …??? 6
STANFORD BIOENGINEERING Riedel-Kruse Lab [email protected]
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What is bioengineering?
8 STANFORD BIOENGINEERING Riedel-Kruse Lab [email protected]
• Biology as an engineering substrate
• Fusion of engineering and the life sciences
• Technology invention • Scientific discovery
• Applications in medicine, food, energy, environment …
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Future Stanford bioengineering building
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Stanford bioengineering
STANFORD BIOENGINEERING Riedel-Kruse Lab [email protected]
Human Biomechanics Scott Delp
Micro-fluidics – Steve Quake; Bubble logic - Manu Prakash
Optogenetics Karl Deisseroth
RNA logic gates Christina Smolke
~500 um
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Electrical vs. biological engineering
Electronic circuit ~1950’s
Micro-fluidic circuit ~2002
STANFORD BIOENGINEERING Riedel-Kruse Lab [email protected]
Transistor 1947
Micro-fluidic valve ~2000
Table Tennis 2006; Xbox 360
?
“Tennis for two” 1958
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Bioengineered games
13 STANFORD BIOENGINEERING Riedel-Kruse Lab [email protected]
(i) Human interaction with biological material or processes (ii) Enabled by modern biotechnology
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“Biotic games”
14 STANFORD BIOENGINEERING Riedel-Kruse Lab [email protected]
(i) Human interaction with biological material or processes (ii) Enabled by modern biotechnology
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Paramecia and random walks
1
567
8
9 43 2
0.5 sec
0.5 mm
50 um
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Biotic game set-up
Biotic processor
Game controller Fluid chamber
17 STANFORD BIOENGINEERING Riedel-Kruse Lab [email protected]
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Pinball vs. “Biotic Pinball”
1 mm / real time
19 STANFORD BIOENGINEERING Riedel-Kruse Lab [email protected]
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Comments on the web • useless.invention.ever • Incredible!
• Are paramecia hurt? Unethical to play with life! • It is more benign than picking a flower
• Cure cancer first!
• If they had Playstation in WW2, that is what the controller probably would look like.
• I really like Stanford having such multidisciplinary research opportunities.
21 STANFORD BIOENGINEERING Riedel-Kruse Lab [email protected]
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Utility of future biotic games
1. Education 2. Large scale citizen science 3. Technology driver 4. …
22 STANFORD BIOENGINEERING Riedel-Kruse Lab [email protected]
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First test with children in museum
24 STANFORD BIOENGINEERING Riedel-Kruse Lab [email protected]
Daniel Schwartz Prof. School of Education, Stanford
Computer games for education
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First children test in museum
25 STANFORD BIOENGINEERING Riedel-Kruse Lab [email protected]
• ~40 children ~10 years old • enjoyed direct visual through scope • biotic game was too difficult to play • hardly realized that they played with real paramecia • no ethical concerns raised
-> different perceptions by age -> implications for improved design
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Biomedical Experiments Operated by Online Gaming Community
Biotic games for large scale science (citizen science / crowdsourcing / human computation)
27 STANFORD BIOENGINEERING Riedel-Kruse Lab [email protected]
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Citizen science game: Beans
28 STANFORD BIOENGINEERING Riedel-Kruse Lab [email protected]
How many beans are in the jar?
Rules:
• Don’t talk • Write down your guess • Write down your name (other ID)
• Best guess wins
• Exchange guess with a stranger
• Let’s vote!
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Rhiju Das Assist. Prof. Biochemistry, Stanford
RNA folding
Adrien Trieulle Assist. Prof. Computer Science /
Robotics; Carnegie Mellon Computer graphics
Biotic games for large scale science
~10.000 players Experimental feedback Once per week for 8 players
29 STANFORD BIOENGINEERING Riedel-Kruse Lab [email protected]
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RNA and folding A G U C A G C A G C C G A A A
A G U
C A
G
C A
G
C C
G A A
A
Folding problem
Sequence problem
A
A
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Eterna : Demonstra-on
http://eterna.cmu.edu/game.php?myType=PUZZLE&myVal=13399
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More complex puzzles
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Game
Experiment Verifica-on
Loop of global scale game playing and experimental trial & error
EteRNA
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EteR
NA
scor
e
Time
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EteR
NA
scor
e
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EteR
NA
scor
e
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EteR
NA
scor
e
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EteR
NA
scor
e
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EteR
NA
scor
e Human
Computer
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Games as technological driver (development of new technology and/or cost reductions)
Jen-Hsun Huang (EE MS ’92 Stanford)
3D video game graphics
41 STANFORD BIOENGINEERING Riedel-Kruse Lab [email protected]
$
Graphics Processing Unit (GPU) Molecular dynamic simulations
"Jen-Hsun Huang School of Engineering Center."
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Games as technological driver (development of new technology and/or cost reductions)
Jen-Hsun Huang (EE MS ’92 Stanford)
3D video game graphics
42 STANFORD BIOENGINEERING Riedel-Kruse Lab [email protected]
$
Graphics Processing Unit (GPU) Molecular dynamic simulations
"Jen-Hsun Huang School of Engineering Center."
Without video games
No deans office
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Hongying Zhu et al. LOC 2010
Could biotic games lower costs for mobile diagnostics? 43
STANFORD BIOENGINEERING Riedel-Kruse Lab [email protected]
Games as technological driver (development of new technology and/or cost reductions)
3rd world mobile phone based diagnostics
Integrating micro-fluidic chips into phones?
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45
Electrical vs. biological engineering
Electronic circuit ~1950’s
Micro-fluidic circuit ~2002
STANFORD BIOENGINEERING Riedel-Kruse Lab [email protected]
Transistor 1947
Micro-fluidic valve ~2000
Table Tennis 2006; Xbox 360
???
“Tennis for two” 1958
Biotic games ~2010
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Stanford Bio.X games initiative!(Founded ~Spring 2010; Bio-X IIP seed-funding ~Fall 2010)!
Rhiju Das (Asst Prof Biochemistry, Physics)
Biotic Games
Ingmar Riedel-Kruse (Asst Prof Bioengineering)
Educational video games
Daniel Schwartz (Prof Education)
Objectives: 1. Develop and build biotic games 2. Use biotic games to solve educational and scientific challenges 3. Nucleate a world-wide biotic games community
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Summary Biotic Games
• Human player interacting with real biology (experiments)
• Novel features • Educational value • Citizen science • Technology driver • …
• Stanford Bio.X games center
47 STANFORD BIOENGINEERING Riedel-Kruse Lab [email protected]