c;.#profdoc.um.ac.ir/articles/a/1038413.pdf · xiii. a noli steady state kinetic evaluation of the...
TRANSCRIPT
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tlr oUu-- yJjJ u b ~I ~ 4)Jo ~jlr JIIrlioU ~ vt 0 Ir tl~ j1lAs
c5-y~I~ ~u c5)b ~1 Jjl Ir ~ ~)ru-- J)jJ ~ 1~1 ~ 4lJo JFS
o ~~ 4ilj)j~ jj rvJ c51jl ~ r~ TT jlb-~ (phenylbutazone) )jtJ~
bullgt c5t1lt i~ bl J)jJ 0)1gt1 j 1r j) v ~~ c5~gt ~1 ~~ c5~gt J)jJ ju
- ~ bullir )1 4oIu ))~ 0)11)) )1lAsBUN Jo-J t ~x tJsJl
1-1 )~xlii-- c5-YU=_1 ~~ c5)b Ia olb ~1~1 lLe ) j1JA~
u~ )~j~ )j rvJ Ijl ~ r~ middot1 )1b- ~ (Isoflupredone acetate)
ir bU c5~gt J)jJ ~ c5)b c5~1 ~ ~u )14oIL )) )1lAs ~ )jtJ ~ J)jJ 1)) 4)))1 I~I)~ eli
middot0 J-I-S Jljil T MCHC Jljil IT J Jljil (0 JA c5tJrlS
-~ IS( ~w ISv ~ ISW -J5ISl ~ 1)IjlJljil
)1lAs ~ I)~xlikyJjJI)) (pltIO)1 ~b)b~ IS((V )gt I5rlTl - bull oljil W )i Jljil ~ JA c5tJrlS )1LU 4oIu ))
jlIST t ~x JjiXTO~ Jo-Jbull IST1l ~ ISjAJ( )iis1
-~ Jljil X~~w Jlji1t to ~ Jljil XTOA-J5 bull IS ((1 )gt )1
(pltoloO)1 ~b)b~ ISj~
~JjlJl~ bulll1 ~J~JjI-~~ ~UISJ)ll c C~iIJ rJM ~Ubullbullh~ ~ ~~l
~lI~ ~ ltS lA4i Jl ltS~J-Ir-i-
l)JA Jl 0~ XJol~ jJr GuiJli ltSlAC--~
fT
f 01 j ~ ~ ~ JJJJO
J jol
v
J
J
tSlJ~Ab tSLjJJ tSl~~ ~lL
T 0) jI JP J$ ~l tSljJJ ~ ~L)
JJ~t ~lA-1
rn = rnl- rn2
010 rnxlOO tJ1JIJ Iw=gtJ~ = 2JoO- rn
jJJ r ~ J~ ~~ ViJ 0 ~~ = rnl
~bull LmiddotIJ
lYJ jI Ji) uU jJJ J~ 01~~~l- = rn2
(JJb
~ ~
J 0JjIJ yJa lYJ jl bulllA1 ~~ ~
J~ ~L) ~J 01~~ ~ u1 0J~liJy1
)bull JJu- I bulllo ~~ r J JW JJ1ushy
~IS~jluIISUr-IJ~ ~~ --J~ - JJ~
J~ ~l1 cJJIJ(uJiI J cJJjliJ ~JJ~ jl ~~
~IjlJ Ji b1 ~I1tJtJliljtl sl~~~
+IA(NS) +OV(NS) j- IStJrlLW
+1(10middotmiddotmiddotmiddot +IVbullbull Jci IStJrlW
+1t +I(NS) 1It +I(NS) - o(NS) vw +middottmiddotmiddotmiddotmiddot -I(NS) MeHC
_o(NS) -fA(NS) MCH
-I(NS) -VA(NS) MCV
(IV(NS) +W ~I
+If(NS) -nfbullbull
WO(NS) -Iff amp1
-IOv(NS) -Wymiddotmiddot ~~I
J~~ ~~ tSlr- ~J~ rl~J JJJJ
~lAIJi ~L tSJ~ tSl4lJ J~ J ci$ ~rA
LtS tSJJI~ EDTA
~ cr ~~ tSlIJ~ tSrS jIu1 ~
jl ~J- J-I ~ ~ 0Y-~~ A 01r- ~ J~
J~~ ~~ tSlr- ~J~ rbJ JJ
jti-rL ~L) tSl4lJJ~ JlotS ci$~rA
JJr-lS BUN tSrSjIu1 J ir tSjLlu-~
tSJJI~ )J J ~Lw t~ ~ ~J~
~$tS
jl ~ 4L1i~ tSjJlJ u~L
Yj tSlJ~ hW LtS i~1 tSrS0Yshy
J ~ts ~~~ 01J-t ~ J ~
o~lA-1 ~ (MCV MCH MCHC) J~tSl~u1
Jt ~)obull ~~ ~ J Ii-~ tSl~JJ jl
gtL ~ ~jAb ~o 0 0 tSjJlA ~Jfill
tSlJ~ ~ ~JW j$ uJ- 0l11
J ~y- ~- ~ jI ~ Iw=gtJ~ uJ-~ ~
j$ UJ- 4J ~ tSr-IJ
~)J)S~JJ ~ ir JJr-lStSrSmiddotjIli1
JJ- ~JJ ~ ir- i V ~Jn tS~middotjlli1
~j JJjJ5 ~JJ ~ ir ~ tSrSmiddotjlli1
~y ~ltS ~JJ ~ ir BUN tSrSjlli1
4 ISP rJi 41-J~ (r r-t J ~ 1Sr$middotjlJ1
ri-i 1Sr$jlJ1 J blS rL F1M2S1 JAo ~
(~)J ~JjltJ jJl) J 5JcJJJ JJJ ~ (r
u~UI tSJLI JJ- J ~~ J~~
~ J dgt~ ~~ ~JU ~JJ jl bull lA ~
bullbullbullbull bullbullbull bullbull
J
( )
-y
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+tolluU
-11
_Vrn
_u -VI +fn
+
e NS
J shy~I ~ I ~ b yl I)v~ IJfIJj J
1 L--Jmiddot_~_~ ~JJ J J~ I1 t~ tul y~ bull- bull
YljtIJ ~
yJJJei- J1Slt-~
~lS ~J (-TV
IS~ (rt)
u lw ltlt_I~~J
-- ISI IS)r
~ hY ulj~1(W) ~ (ttL yAjj
s~(WA)
(n)
(pltO05)
b
)1 jl ACTH ( )
ISJJ
J
(n)
(V)
J
J
J
J J J
J
J
Y)
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)
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v~)tiT J~ ~ cP~
(YI)
~IJI JJ Dtl
vt=-6yeni JJ~~ JJI
~)rJ1 ltbh~ J
(t) f~
~I
J
J
V) ub~ J (Wanner)
~ SJ ti
J I5J~ J (0)
tS)~ Jb~ ~ JJi J
~~~o~~ Wtl s ~~ ci~ ~S
( Wo) ~r=-~
~~S (~A) uL~ J
( ~A ) u6~ J -115t(S)Jgt 4
u=t9J ~ jllJ ~~S ~ ~1 JJ
Wtl JJ 4 ~hil Wtl J 1 OIJ (A J YO) ))1 uJgtlu
~ uJlb Wtl JiIJ J ~) )I)~ ~S
~ J ) uJgtVt t(SJJgt fil
I~ uly~ ul 151Jgt ~6- J6- Jl
I 15J15tJ I5tJLI5J) Jgt UJjbYo
~p ( 15t4JfiJl
JJ-IS )iU
J rt (pltOOl) 1 ci~ ~Ijl I5Jb~
( ~A) vJ$
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h Jb jl JJ ~ uy 15t-~ u=t9) jl
J ti ~ r=-~ ~) utw (SJJ Wtl )
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Jl jJJ ulo ~ ~ jJJ Jl ui uJJ rP ~
(YO)
(AY) uL~ J (Bronder)
JJj-3 J~- ~) U~I JJ~ L
4 UJJby ~ (Y) ~Iu tY-Jrp UJjbYo ~
~) U~l J 15J ~~I
Jl (1 ~~ (II J
J H ( 0) T 0l1li L ulo u-i~1
u~(AT) uL~
J~ ~ ---Jlr-shy
umiddotv 0
AUiI ( tJ J olS J ( AT) otJ) ( IAf) J (Morris)
J) ~
J
JJJ5
J J~I ~ts
OJJJ-iI U ~IS J)
1$ jl
1_- - )I~ + J 17 8J
(YV) ~ o~) rb J
The IOWa Stctte Univensity Press USA
20shy hrnnvl~ responses test In
hormones Am J Vet Res 49 503gt507
21 doses of 9-tJ-flunmrefiinisl3iorle acetate lM on blood 811iUIi~ serum
Sci 43 553
22shy on the eosillolphllic 1e~Yle poJ)ul8l1on of
rat tlleue I Duametbasone J of Pharmacol 189 303gt310
23 shy 1981 InJllleD=e the blood
picture of cattle Tlelranillcl1e UITiIIIhIIl11 51 2785
24 shy DP 1970 A clnicians views on the IlIIe tmd misIlIIe of phEnYll3utIIZOliIe Eq Vet J 4 63gt65
25 shy H r PM 1981
toxicosis in A ~helmlCaI Am J Vet Res 42
M 1983 Tkbullbullbull_11 nubullI1
normal
MD 1974 The effect of
26middot 1986 Textbook of anlcal ChImiddot WE saunders
27 PR and
44 1410-1418
LM 1983
28- Wanner
acetyiaiion In the hone
R 1979 A prellmlrillY
Inl MedCDrIihd Eds T Tobins JW Black tmd WE Woods LalngltonKellltud~
1shy
0
References Athens JW Boggs DR Wanner HR Cartwright GE and Wintrobe MM 1968
XiiI A noli steady state kinetic evaluation of the mechanism of cortisone induced
grllll1uJllicytgtsis J Cln 249
2shy Brlllnder GC Pugh DM ltUld B~er RJ 1982 Veterimuy Applied Pharmacology and Therapeutic
4th ed Greyecat hOUlle London England
3shy EH 1986 Veterinary Cnical PathI 4th ed WB Saunders Compo Philadelphia
4shy LG and Tyler DE 1985 ExperimentallY induced pnenylbutatooe toKicCISis in ponies
Description of the and its prevention with synthetic PGE2 Vet Res 48 1605-1615
5shy IdA~lst()ne D Mueller Heubach E and Caritis SN 1978 Effect of dexamethasone on leukocyte count
in pregnant sheep and fetalllllmbs Amer J Obst Onco 131 677-681
6shy Fauci DIllie DC and JE 1976 Glucocorlicoid of acHon and
clinical conSideration Ann Inter Med 84 309
7 shy Glade M J 1975 Chronic dexamethasone treatment to horse and pony foals Dissertation Abstract
International 41 6-7
8shy Goodman LS and A 1986 The Pharmacological Basis of a ~UIIIll 5th ed Macmillan
PubllShingCelnc New York USA
9shy Cbullbull____ DE 1983 Renal necrClSis in horses JAVMA 182 263-266
10 shy and L 1983 Renal papillary necrClSis in horses after phenylbutazone and water
deprivation Vet PllIthol 20 603-610
11 - Horrobin DF 1971 Essentillll Biochemistry Endocrinology and Nutrition MTP Com pp 86-87
12 shy Jones LM 1988 Veterinlllry Pharmacology and Therapeutics 6th ed The Iowa Stcde University
Press
13 - Kaneko JJ 1980 Clinical Biochemistry of Domestic Animals 3rd ed Academic Press Inc
New York
14 shy BG 1989 Basic and Clinical Pharmacology 4th ed Prentice Hau International (UK)
London
15 shy Creed Gerring EEL Gould PW Humphreys DJ Michell AR lind
Tayler JB 1983 Biochemical and haematologicaleffects of phenylbutazone in horses Vet J 15
158-176
16 shy Lees P and Higgins AJ 1985 Clinical pharmacology and therapeutic uses of non-steroidal
the horse Eq Vet J 17 83-96
17 shy MagnusonS KL E1978 In vitro and vivo effects
ohortioosteroids on blood lymphocytes from Am J Vet Res 39 gt1-wIo
18 shy TJ 1979 The pharmacologic interactions with laboratory test 596 Burnham
Etobiocoke Ontario Canada
19 shy Maxine M B5 1960 Outline of Veterinary Clnica Pathology_ 2nd ed pp 131-132
J No 1991
SUlLdlJ on
tn1l1amlrn2lto~ry n1lIIIInrR on 014100 J]lidule
sheep
Sa1rmldii AA
ZtllDlDlalry
In this from Veterirlaru School Animal
HulbllndilUY Unit were from 40 to
age was from 2~4 years old
blood )08tameters
Keywords
fT
f 01 j ~ ~ ~ JJJJO
J jol
v
J
J
tSlJ~Ab tSLjJJ tSl~~ ~lL
T 0) jI JP J$ ~l tSljJJ ~ ~L)
JJ~t ~lA-1
rn = rnl- rn2
010 rnxlOO tJ1JIJ Iw=gtJ~ = 2JoO- rn
jJJ r ~ J~ ~~ ViJ 0 ~~ = rnl
~bull LmiddotIJ
lYJ jI Ji) uU jJJ J~ 01~~~l- = rn2
(JJb
~ ~
J 0JjIJ yJa lYJ jl bulllA1 ~~ ~
J~ ~L) ~J 01~~ ~ u1 0J~liJy1
)bull JJu- I bulllo ~~ r J JW JJ1ushy
~IS~jluIISUr-IJ~ ~~ --J~ - JJ~
J~ ~l1 cJJIJ(uJiI J cJJjliJ ~JJ~ jl ~~
~IjlJ Ji b1 ~I1tJtJliljtl sl~~~
+IA(NS) +OV(NS) j- IStJrlLW
+1(10middotmiddotmiddotmiddot +IVbullbull Jci IStJrlW
+1t +I(NS) 1It +I(NS) - o(NS) vw +middottmiddotmiddotmiddotmiddot -I(NS) MeHC
_o(NS) -fA(NS) MCH
-I(NS) -VA(NS) MCV
(IV(NS) +W ~I
+If(NS) -nfbullbull
WO(NS) -Iff amp1
-IOv(NS) -Wymiddotmiddot ~~I
J~~ ~~ tSlr- ~J~ rl~J JJJJ
~lAIJi ~L tSJ~ tSl4lJ J~ J ci$ ~rA
LtS tSJJI~ EDTA
~ cr ~~ tSlIJ~ tSrS jIu1 ~
jl ~J- J-I ~ ~ 0Y-~~ A 01r- ~ J~
J~~ ~~ tSlr- ~J~ rbJ JJ
jti-rL ~L) tSl4lJJ~ JlotS ci$~rA
JJr-lS BUN tSrSjIu1 J ir tSjLlu-~
tSJJI~ )J J ~Lw t~ ~ ~J~
~$tS
jl ~ 4L1i~ tSjJlJ u~L
Yj tSlJ~ hW LtS i~1 tSrS0Yshy
J ~ts ~~~ 01J-t ~ J ~
o~lA-1 ~ (MCV MCH MCHC) J~tSl~u1
Jt ~)obull ~~ ~ J Ii-~ tSl~JJ jl
gtL ~ ~jAb ~o 0 0 tSjJlA ~Jfill
tSlJ~ ~ ~JW j$ uJ- 0l11
J ~y- ~- ~ jI ~ Iw=gtJ~ uJ-~ ~
j$ UJ- 4J ~ tSr-IJ
~)J)S~JJ ~ ir JJr-lStSrSmiddotjIli1
JJ- ~JJ ~ ir- i V ~Jn tS~middotjlli1
~j JJjJ5 ~JJ ~ ir ~ tSrSmiddotjlli1
~y ~ltS ~JJ ~ ir BUN tSrSjlli1
4 ISP rJi 41-J~ (r r-t J ~ 1Sr$middotjlJ1
ri-i 1Sr$jlJ1 J blS rL F1M2S1 JAo ~
(~)J ~JjltJ jJl) J 5JcJJJ JJJ ~ (r
u~UI tSJLI JJ- J ~~ J~~
~ J dgt~ ~~ ~JU ~JJ jl bull lA ~
bullbullbullbull bullbullbull bullbull
J
( )
-y
_HU
+tolluU
-11
_Vrn
_u -VI +fn
+
e NS
J shy~I ~ I ~ b yl I)v~ IJfIJj J
1 L--Jmiddot_~_~ ~JJ J J~ I1 t~ tul y~ bull- bull
YljtIJ ~
yJJJei- J1Slt-~
~lS ~J (-TV
IS~ (rt)
u lw ltlt_I~~J
-- ISI IS)r
~ hY ulj~1(W) ~ (ttL yAjj
s~(WA)
(n)
(pltO05)
b
)1 jl ACTH ( )
ISJJ
J
(n)
(V)
J
J
J
J J J
J
J
Y)
J
)
J --- shy
~ e-~ JI UJJ llA ~ tJJ Dtl
v~)tiT J~ ~ cP~
(YI)
~IJI JJ Dtl
vt=-6yeni JJ~~ JJI
~)rJ1 ltbh~ J
(t) f~
~I
J
J
V) ub~ J (Wanner)
~ SJ ti
J I5J~ J (0)
tS)~ Jb~ ~ JJi J
~~~o~~ Wtl s ~~ ci~ ~S
( Wo) ~r=-~
~~S (~A) uL~ J
( ~A ) u6~ J -115t(S)Jgt 4
u=t9J ~ jllJ ~~S ~ ~1 JJ
Wtl JJ 4 ~hil Wtl J 1 OIJ (A J YO) ))1 uJgtlu
~ uJlb Wtl JiIJ J ~) )I)~ ~S
~ J ) uJgtVt t(SJJgt fil
I~ uly~ ul 151Jgt ~6- J6- Jl
I 15J15tJ I5tJLI5J) Jgt UJjbYo
~p ( 15t4JfiJl
JJ-IS )iU
J rt (pltOOl) 1 ci~ ~Ijl I5Jb~
( ~A) vJ$
yJ YA 15t~1 uJe-I~1 ~Ij
(A) la~ ~S
~LS (JS uly~ Wt J
15t~j r pi Lt-~ LJ
h Jb jl JJ ~ uy 15t-~ u=t9) jl
J ti ~ r=-~ ~) utw (SJJ Wtl )
jI ~Ici~ ~S 15)~ J1~ uYJJ~ uji
~ (~A) uL~ J
~ uy)f J ~ul~ )l
- jJJ Jl UJjbYo rPJt J J)i ~ ~T
151Jgt rPJt ltgt JJ) 4~~l~ t~bfiJl
Jl jJJ ulo ~ ~ jJJ Jl ui uJJ rP ~
(YO)
(AY) uL~ J (Bronder)
JJj-3 J~- ~) U~I JJ~ L
4 UJJby ~ (Y) ~Iu tY-Jrp UJjbYo ~
~) U~l J 15J ~~I
Jl (1 ~~ (II J
J H ( 0) T 0l1li L ulo u-i~1
u~(AT) uL~
J~ ~ ---Jlr-shy
umiddotv 0
AUiI ( tJ J olS J ( AT) otJ) ( IAf) J (Morris)
J) ~
J
JJJ5
J J~I ~ts
OJJJ-iI U ~IS J)
1$ jl
1_- - )I~ + J 17 8J
(YV) ~ o~) rb J
The IOWa Stctte Univensity Press USA
20shy hrnnvl~ responses test In
hormones Am J Vet Res 49 503gt507
21 doses of 9-tJ-flunmrefiinisl3iorle acetate lM on blood 811iUIi~ serum
Sci 43 553
22shy on the eosillolphllic 1e~Yle poJ)ul8l1on of
rat tlleue I Duametbasone J of Pharmacol 189 303gt310
23 shy 1981 InJllleD=e the blood
picture of cattle Tlelranillcl1e UITiIIIhIIl11 51 2785
24 shy DP 1970 A clnicians views on the IlIIe tmd misIlIIe of phEnYll3utIIZOliIe Eq Vet J 4 63gt65
25 shy H r PM 1981
toxicosis in A ~helmlCaI Am J Vet Res 42
M 1983 Tkbullbullbull_11 nubullI1
normal
MD 1974 The effect of
26middot 1986 Textbook of anlcal ChImiddot WE saunders
27 PR and
44 1410-1418
LM 1983
28- Wanner
acetyiaiion In the hone
R 1979 A prellmlrillY
Inl MedCDrIihd Eds T Tobins JW Black tmd WE Woods LalngltonKellltud~
1shy
0
References Athens JW Boggs DR Wanner HR Cartwright GE and Wintrobe MM 1968
XiiI A noli steady state kinetic evaluation of the mechanism of cortisone induced
grllll1uJllicytgtsis J Cln 249
2shy Brlllnder GC Pugh DM ltUld B~er RJ 1982 Veterimuy Applied Pharmacology and Therapeutic
4th ed Greyecat hOUlle London England
3shy EH 1986 Veterinary Cnical PathI 4th ed WB Saunders Compo Philadelphia
4shy LG and Tyler DE 1985 ExperimentallY induced pnenylbutatooe toKicCISis in ponies
Description of the and its prevention with synthetic PGE2 Vet Res 48 1605-1615
5shy IdA~lst()ne D Mueller Heubach E and Caritis SN 1978 Effect of dexamethasone on leukocyte count
in pregnant sheep and fetalllllmbs Amer J Obst Onco 131 677-681
6shy Fauci DIllie DC and JE 1976 Glucocorlicoid of acHon and
clinical conSideration Ann Inter Med 84 309
7 shy Glade M J 1975 Chronic dexamethasone treatment to horse and pony foals Dissertation Abstract
International 41 6-7
8shy Goodman LS and A 1986 The Pharmacological Basis of a ~UIIIll 5th ed Macmillan
PubllShingCelnc New York USA
9shy Cbullbull____ DE 1983 Renal necrClSis in horses JAVMA 182 263-266
10 shy and L 1983 Renal papillary necrClSis in horses after phenylbutazone and water
deprivation Vet PllIthol 20 603-610
11 - Horrobin DF 1971 Essentillll Biochemistry Endocrinology and Nutrition MTP Com pp 86-87
12 shy Jones LM 1988 Veterinlllry Pharmacology and Therapeutics 6th ed The Iowa Stcde University
Press
13 - Kaneko JJ 1980 Clinical Biochemistry of Domestic Animals 3rd ed Academic Press Inc
New York
14 shy BG 1989 Basic and Clinical Pharmacology 4th ed Prentice Hau International (UK)
London
15 shy Creed Gerring EEL Gould PW Humphreys DJ Michell AR lind
Tayler JB 1983 Biochemical and haematologicaleffects of phenylbutazone in horses Vet J 15
158-176
16 shy Lees P and Higgins AJ 1985 Clinical pharmacology and therapeutic uses of non-steroidal
the horse Eq Vet J 17 83-96
17 shy MagnusonS KL E1978 In vitro and vivo effects
ohortioosteroids on blood lymphocytes from Am J Vet Res 39 gt1-wIo
18 shy TJ 1979 The pharmacologic interactions with laboratory test 596 Burnham
Etobiocoke Ontario Canada
19 shy Maxine M B5 1960 Outline of Veterinary Clnica Pathology_ 2nd ed pp 131-132
J No 1991
SUlLdlJ on
tn1l1amlrn2lto~ry n1lIIIInrR on 014100 J]lidule
sheep
Sa1rmldii AA
ZtllDlDlalry
In this from Veterirlaru School Animal
HulbllndilUY Unit were from 40 to
age was from 2~4 years old
blood )08tameters
Keywords
tSlJ~Ab tSLjJJ tSl~~ ~lL
T 0) jI JP J$ ~l tSljJJ ~ ~L)
JJ~t ~lA-1
rn = rnl- rn2
010 rnxlOO tJ1JIJ Iw=gtJ~ = 2JoO- rn
jJJ r ~ J~ ~~ ViJ 0 ~~ = rnl
~bull LmiddotIJ
lYJ jI Ji) uU jJJ J~ 01~~~l- = rn2
(JJb
~ ~
J 0JjIJ yJa lYJ jl bulllA1 ~~ ~
J~ ~L) ~J 01~~ ~ u1 0J~liJy1
)bull JJu- I bulllo ~~ r J JW JJ1ushy
~IS~jluIISUr-IJ~ ~~ --J~ - JJ~
J~ ~l1 cJJIJ(uJiI J cJJjliJ ~JJ~ jl ~~
~IjlJ Ji b1 ~I1tJtJliljtl sl~~~
+IA(NS) +OV(NS) j- IStJrlLW
+1(10middotmiddotmiddotmiddot +IVbullbull Jci IStJrlW
+1t +I(NS) 1It +I(NS) - o(NS) vw +middottmiddotmiddotmiddotmiddot -I(NS) MeHC
_o(NS) -fA(NS) MCH
-I(NS) -VA(NS) MCV
(IV(NS) +W ~I
+If(NS) -nfbullbull
WO(NS) -Iff amp1
-IOv(NS) -Wymiddotmiddot ~~I
J~~ ~~ tSlr- ~J~ rl~J JJJJ
~lAIJi ~L tSJ~ tSl4lJ J~ J ci$ ~rA
LtS tSJJI~ EDTA
~ cr ~~ tSlIJ~ tSrS jIu1 ~
jl ~J- J-I ~ ~ 0Y-~~ A 01r- ~ J~
J~~ ~~ tSlr- ~J~ rbJ JJ
jti-rL ~L) tSl4lJJ~ JlotS ci$~rA
JJr-lS BUN tSrSjIu1 J ir tSjLlu-~
tSJJI~ )J J ~Lw t~ ~ ~J~
~$tS
jl ~ 4L1i~ tSjJlJ u~L
Yj tSlJ~ hW LtS i~1 tSrS0Yshy
J ~ts ~~~ 01J-t ~ J ~
o~lA-1 ~ (MCV MCH MCHC) J~tSl~u1
Jt ~)obull ~~ ~ J Ii-~ tSl~JJ jl
gtL ~ ~jAb ~o 0 0 tSjJlA ~Jfill
tSlJ~ ~ ~JW j$ uJ- 0l11
J ~y- ~- ~ jI ~ Iw=gtJ~ uJ-~ ~
j$ UJ- 4J ~ tSr-IJ
~)J)S~JJ ~ ir JJr-lStSrSmiddotjIli1
JJ- ~JJ ~ ir- i V ~Jn tS~middotjlli1
~j JJjJ5 ~JJ ~ ir ~ tSrSmiddotjlli1
~y ~ltS ~JJ ~ ir BUN tSrSjlli1
4 ISP rJi 41-J~ (r r-t J ~ 1Sr$middotjlJ1
ri-i 1Sr$jlJ1 J blS rL F1M2S1 JAo ~
(~)J ~JjltJ jJl) J 5JcJJJ JJJ ~ (r
u~UI tSJLI JJ- J ~~ J~~
~ J dgt~ ~~ ~JU ~JJ jl bull lA ~
bullbullbullbull bullbullbull bullbull
J
( )
-y
_HU
+tolluU
-11
_Vrn
_u -VI +fn
+
e NS
J shy~I ~ I ~ b yl I)v~ IJfIJj J
1 L--Jmiddot_~_~ ~JJ J J~ I1 t~ tul y~ bull- bull
YljtIJ ~
yJJJei- J1Slt-~
~lS ~J (-TV
IS~ (rt)
u lw ltlt_I~~J
-- ISI IS)r
~ hY ulj~1(W) ~ (ttL yAjj
s~(WA)
(n)
(pltO05)
b
)1 jl ACTH ( )
ISJJ
J
(n)
(V)
J
J
J
J J J
J
J
Y)
J
)
J --- shy
~ e-~ JI UJJ llA ~ tJJ Dtl
v~)tiT J~ ~ cP~
(YI)
~IJI JJ Dtl
vt=-6yeni JJ~~ JJI
~)rJ1 ltbh~ J
(t) f~
~I
J
J
V) ub~ J (Wanner)
~ SJ ti
J I5J~ J (0)
tS)~ Jb~ ~ JJi J
~~~o~~ Wtl s ~~ ci~ ~S
( Wo) ~r=-~
~~S (~A) uL~ J
( ~A ) u6~ J -115t(S)Jgt 4
u=t9J ~ jllJ ~~S ~ ~1 JJ
Wtl JJ 4 ~hil Wtl J 1 OIJ (A J YO) ))1 uJgtlu
~ uJlb Wtl JiIJ J ~) )I)~ ~S
~ J ) uJgtVt t(SJJgt fil
I~ uly~ ul 151Jgt ~6- J6- Jl
I 15J15tJ I5tJLI5J) Jgt UJjbYo
~p ( 15t4JfiJl
JJ-IS )iU
J rt (pltOOl) 1 ci~ ~Ijl I5Jb~
( ~A) vJ$
yJ YA 15t~1 uJe-I~1 ~Ij
(A) la~ ~S
~LS (JS uly~ Wt J
15t~j r pi Lt-~ LJ
h Jb jl JJ ~ uy 15t-~ u=t9) jl
J ti ~ r=-~ ~) utw (SJJ Wtl )
jI ~Ici~ ~S 15)~ J1~ uYJJ~ uji
~ (~A) uL~ J
~ uy)f J ~ul~ )l
- jJJ Jl UJjbYo rPJt J J)i ~ ~T
151Jgt rPJt ltgt JJ) 4~~l~ t~bfiJl
Jl jJJ ulo ~ ~ jJJ Jl ui uJJ rP ~
(YO)
(AY) uL~ J (Bronder)
JJj-3 J~- ~) U~I JJ~ L
4 UJJby ~ (Y) ~Iu tY-Jrp UJjbYo ~
~) U~l J 15J ~~I
Jl (1 ~~ (II J
J H ( 0) T 0l1li L ulo u-i~1
u~(AT) uL~
J~ ~ ---Jlr-shy
umiddotv 0
AUiI ( tJ J olS J ( AT) otJ) ( IAf) J (Morris)
J) ~
J
JJJ5
J J~I ~ts
OJJJ-iI U ~IS J)
1$ jl
1_- - )I~ + J 17 8J
(YV) ~ o~) rb J
The IOWa Stctte Univensity Press USA
20shy hrnnvl~ responses test In
hormones Am J Vet Res 49 503gt507
21 doses of 9-tJ-flunmrefiinisl3iorle acetate lM on blood 811iUIi~ serum
Sci 43 553
22shy on the eosillolphllic 1e~Yle poJ)ul8l1on of
rat tlleue I Duametbasone J of Pharmacol 189 303gt310
23 shy 1981 InJllleD=e the blood
picture of cattle Tlelranillcl1e UITiIIIhIIl11 51 2785
24 shy DP 1970 A clnicians views on the IlIIe tmd misIlIIe of phEnYll3utIIZOliIe Eq Vet J 4 63gt65
25 shy H r PM 1981
toxicosis in A ~helmlCaI Am J Vet Res 42
M 1983 Tkbullbullbull_11 nubullI1
normal
MD 1974 The effect of
26middot 1986 Textbook of anlcal ChImiddot WE saunders
27 PR and
44 1410-1418
LM 1983
28- Wanner
acetyiaiion In the hone
R 1979 A prellmlrillY
Inl MedCDrIihd Eds T Tobins JW Black tmd WE Woods LalngltonKellltud~
1shy
0
References Athens JW Boggs DR Wanner HR Cartwright GE and Wintrobe MM 1968
XiiI A noli steady state kinetic evaluation of the mechanism of cortisone induced
grllll1uJllicytgtsis J Cln 249
2shy Brlllnder GC Pugh DM ltUld B~er RJ 1982 Veterimuy Applied Pharmacology and Therapeutic
4th ed Greyecat hOUlle London England
3shy EH 1986 Veterinary Cnical PathI 4th ed WB Saunders Compo Philadelphia
4shy LG and Tyler DE 1985 ExperimentallY induced pnenylbutatooe toKicCISis in ponies
Description of the and its prevention with synthetic PGE2 Vet Res 48 1605-1615
5shy IdA~lst()ne D Mueller Heubach E and Caritis SN 1978 Effect of dexamethasone on leukocyte count
in pregnant sheep and fetalllllmbs Amer J Obst Onco 131 677-681
6shy Fauci DIllie DC and JE 1976 Glucocorlicoid of acHon and
clinical conSideration Ann Inter Med 84 309
7 shy Glade M J 1975 Chronic dexamethasone treatment to horse and pony foals Dissertation Abstract
International 41 6-7
8shy Goodman LS and A 1986 The Pharmacological Basis of a ~UIIIll 5th ed Macmillan
PubllShingCelnc New York USA
9shy Cbullbull____ DE 1983 Renal necrClSis in horses JAVMA 182 263-266
10 shy and L 1983 Renal papillary necrClSis in horses after phenylbutazone and water
deprivation Vet PllIthol 20 603-610
11 - Horrobin DF 1971 Essentillll Biochemistry Endocrinology and Nutrition MTP Com pp 86-87
12 shy Jones LM 1988 Veterinlllry Pharmacology and Therapeutics 6th ed The Iowa Stcde University
Press
13 - Kaneko JJ 1980 Clinical Biochemistry of Domestic Animals 3rd ed Academic Press Inc
New York
14 shy BG 1989 Basic and Clinical Pharmacology 4th ed Prentice Hau International (UK)
London
15 shy Creed Gerring EEL Gould PW Humphreys DJ Michell AR lind
Tayler JB 1983 Biochemical and haematologicaleffects of phenylbutazone in horses Vet J 15
158-176
16 shy Lees P and Higgins AJ 1985 Clinical pharmacology and therapeutic uses of non-steroidal
the horse Eq Vet J 17 83-96
17 shy MagnusonS KL E1978 In vitro and vivo effects
ohortioosteroids on blood lymphocytes from Am J Vet Res 39 gt1-wIo
18 shy TJ 1979 The pharmacologic interactions with laboratory test 596 Burnham
Etobiocoke Ontario Canada
19 shy Maxine M B5 1960 Outline of Veterinary Clnica Pathology_ 2nd ed pp 131-132
J No 1991
SUlLdlJ on
tn1l1amlrn2lto~ry n1lIIIInrR on 014100 J]lidule
sheep
Sa1rmldii AA
ZtllDlDlalry
In this from Veterirlaru School Animal
HulbllndilUY Unit were from 40 to
age was from 2~4 years old
blood )08tameters
Keywords
bullbullbullbull bullbullbull bullbull
J
( )
-y
_HU
+tolluU
-11
_Vrn
_u -VI +fn
+
e NS
J shy~I ~ I ~ b yl I)v~ IJfIJj J
1 L--Jmiddot_~_~ ~JJ J J~ I1 t~ tul y~ bull- bull
YljtIJ ~
yJJJei- J1Slt-~
~lS ~J (-TV
IS~ (rt)
u lw ltlt_I~~J
-- ISI IS)r
~ hY ulj~1(W) ~ (ttL yAjj
s~(WA)
(n)
(pltO05)
b
)1 jl ACTH ( )
ISJJ
J
(n)
(V)
J
J
J
J J J
J
J
Y)
J
)
J --- shy
~ e-~ JI UJJ llA ~ tJJ Dtl
v~)tiT J~ ~ cP~
(YI)
~IJI JJ Dtl
vt=-6yeni JJ~~ JJI
~)rJ1 ltbh~ J
(t) f~
~I
J
J
V) ub~ J (Wanner)
~ SJ ti
J I5J~ J (0)
tS)~ Jb~ ~ JJi J
~~~o~~ Wtl s ~~ ci~ ~S
( Wo) ~r=-~
~~S (~A) uL~ J
( ~A ) u6~ J -115t(S)Jgt 4
u=t9J ~ jllJ ~~S ~ ~1 JJ
Wtl JJ 4 ~hil Wtl J 1 OIJ (A J YO) ))1 uJgtlu
~ uJlb Wtl JiIJ J ~) )I)~ ~S
~ J ) uJgtVt t(SJJgt fil
I~ uly~ ul 151Jgt ~6- J6- Jl
I 15J15tJ I5tJLI5J) Jgt UJjbYo
~p ( 15t4JfiJl
JJ-IS )iU
J rt (pltOOl) 1 ci~ ~Ijl I5Jb~
( ~A) vJ$
yJ YA 15t~1 uJe-I~1 ~Ij
(A) la~ ~S
~LS (JS uly~ Wt J
15t~j r pi Lt-~ LJ
h Jb jl JJ ~ uy 15t-~ u=t9) jl
J ti ~ r=-~ ~) utw (SJJ Wtl )
jI ~Ici~ ~S 15)~ J1~ uYJJ~ uji
~ (~A) uL~ J
~ uy)f J ~ul~ )l
- jJJ Jl UJjbYo rPJt J J)i ~ ~T
151Jgt rPJt ltgt JJ) 4~~l~ t~bfiJl
Jl jJJ ulo ~ ~ jJJ Jl ui uJJ rP ~
(YO)
(AY) uL~ J (Bronder)
JJj-3 J~- ~) U~I JJ~ L
4 UJJby ~ (Y) ~Iu tY-Jrp UJjbYo ~
~) U~l J 15J ~~I
Jl (1 ~~ (II J
J H ( 0) T 0l1li L ulo u-i~1
u~(AT) uL~
J~ ~ ---Jlr-shy
umiddotv 0
AUiI ( tJ J olS J ( AT) otJ) ( IAf) J (Morris)
J) ~
J
JJJ5
J J~I ~ts
OJJJ-iI U ~IS J)
1$ jl
1_- - )I~ + J 17 8J
(YV) ~ o~) rb J
The IOWa Stctte Univensity Press USA
20shy hrnnvl~ responses test In
hormones Am J Vet Res 49 503gt507
21 doses of 9-tJ-flunmrefiinisl3iorle acetate lM on blood 811iUIi~ serum
Sci 43 553
22shy on the eosillolphllic 1e~Yle poJ)ul8l1on of
rat tlleue I Duametbasone J of Pharmacol 189 303gt310
23 shy 1981 InJllleD=e the blood
picture of cattle Tlelranillcl1e UITiIIIhIIl11 51 2785
24 shy DP 1970 A clnicians views on the IlIIe tmd misIlIIe of phEnYll3utIIZOliIe Eq Vet J 4 63gt65
25 shy H r PM 1981
toxicosis in A ~helmlCaI Am J Vet Res 42
M 1983 Tkbullbullbull_11 nubullI1
normal
MD 1974 The effect of
26middot 1986 Textbook of anlcal ChImiddot WE saunders
27 PR and
44 1410-1418
LM 1983
28- Wanner
acetyiaiion In the hone
R 1979 A prellmlrillY
Inl MedCDrIihd Eds T Tobins JW Black tmd WE Woods LalngltonKellltud~
1shy
0
References Athens JW Boggs DR Wanner HR Cartwright GE and Wintrobe MM 1968
XiiI A noli steady state kinetic evaluation of the mechanism of cortisone induced
grllll1uJllicytgtsis J Cln 249
2shy Brlllnder GC Pugh DM ltUld B~er RJ 1982 Veterimuy Applied Pharmacology and Therapeutic
4th ed Greyecat hOUlle London England
3shy EH 1986 Veterinary Cnical PathI 4th ed WB Saunders Compo Philadelphia
4shy LG and Tyler DE 1985 ExperimentallY induced pnenylbutatooe toKicCISis in ponies
Description of the and its prevention with synthetic PGE2 Vet Res 48 1605-1615
5shy IdA~lst()ne D Mueller Heubach E and Caritis SN 1978 Effect of dexamethasone on leukocyte count
in pregnant sheep and fetalllllmbs Amer J Obst Onco 131 677-681
6shy Fauci DIllie DC and JE 1976 Glucocorlicoid of acHon and
clinical conSideration Ann Inter Med 84 309
7 shy Glade M J 1975 Chronic dexamethasone treatment to horse and pony foals Dissertation Abstract
International 41 6-7
8shy Goodman LS and A 1986 The Pharmacological Basis of a ~UIIIll 5th ed Macmillan
PubllShingCelnc New York USA
9shy Cbullbull____ DE 1983 Renal necrClSis in horses JAVMA 182 263-266
10 shy and L 1983 Renal papillary necrClSis in horses after phenylbutazone and water
deprivation Vet PllIthol 20 603-610
11 - Horrobin DF 1971 Essentillll Biochemistry Endocrinology and Nutrition MTP Com pp 86-87
12 shy Jones LM 1988 Veterinlllry Pharmacology and Therapeutics 6th ed The Iowa Stcde University
Press
13 - Kaneko JJ 1980 Clinical Biochemistry of Domestic Animals 3rd ed Academic Press Inc
New York
14 shy BG 1989 Basic and Clinical Pharmacology 4th ed Prentice Hau International (UK)
London
15 shy Creed Gerring EEL Gould PW Humphreys DJ Michell AR lind
Tayler JB 1983 Biochemical and haematologicaleffects of phenylbutazone in horses Vet J 15
158-176
16 shy Lees P and Higgins AJ 1985 Clinical pharmacology and therapeutic uses of non-steroidal
the horse Eq Vet J 17 83-96
17 shy MagnusonS KL E1978 In vitro and vivo effects
ohortioosteroids on blood lymphocytes from Am J Vet Res 39 gt1-wIo
18 shy TJ 1979 The pharmacologic interactions with laboratory test 596 Burnham
Etobiocoke Ontario Canada
19 shy Maxine M B5 1960 Outline of Veterinary Clnica Pathology_ 2nd ed pp 131-132
J No 1991
SUlLdlJ on
tn1l1amlrn2lto~ry n1lIIIInrR on 014100 J]lidule
sheep
Sa1rmldii AA
ZtllDlDlalry
In this from Veterirlaru School Animal
HulbllndilUY Unit were from 40 to
age was from 2~4 years old
blood )08tameters
Keywords
J shy~I ~ I ~ b yl I)v~ IJfIJj J
1 L--Jmiddot_~_~ ~JJ J J~ I1 t~ tul y~ bull- bull
YljtIJ ~
yJJJei- J1Slt-~
~lS ~J (-TV
IS~ (rt)
u lw ltlt_I~~J
-- ISI IS)r
~ hY ulj~1(W) ~ (ttL yAjj
s~(WA)
(n)
(pltO05)
b
)1 jl ACTH ( )
ISJJ
J
(n)
(V)
J
J
J
J J J
J
J
Y)
J
)
J --- shy
~ e-~ JI UJJ llA ~ tJJ Dtl
v~)tiT J~ ~ cP~
(YI)
~IJI JJ Dtl
vt=-6yeni JJ~~ JJI
~)rJ1 ltbh~ J
(t) f~
~I
J
J
V) ub~ J (Wanner)
~ SJ ti
J I5J~ J (0)
tS)~ Jb~ ~ JJi J
~~~o~~ Wtl s ~~ ci~ ~S
( Wo) ~r=-~
~~S (~A) uL~ J
( ~A ) u6~ J -115t(S)Jgt 4
u=t9J ~ jllJ ~~S ~ ~1 JJ
Wtl JJ 4 ~hil Wtl J 1 OIJ (A J YO) ))1 uJgtlu
~ uJlb Wtl JiIJ J ~) )I)~ ~S
~ J ) uJgtVt t(SJJgt fil
I~ uly~ ul 151Jgt ~6- J6- Jl
I 15J15tJ I5tJLI5J) Jgt UJjbYo
~p ( 15t4JfiJl
JJ-IS )iU
J rt (pltOOl) 1 ci~ ~Ijl I5Jb~
( ~A) vJ$
yJ YA 15t~1 uJe-I~1 ~Ij
(A) la~ ~S
~LS (JS uly~ Wt J
15t~j r pi Lt-~ LJ
h Jb jl JJ ~ uy 15t-~ u=t9) jl
J ti ~ r=-~ ~) utw (SJJ Wtl )
jI ~Ici~ ~S 15)~ J1~ uYJJ~ uji
~ (~A) uL~ J
~ uy)f J ~ul~ )l
- jJJ Jl UJjbYo rPJt J J)i ~ ~T
151Jgt rPJt ltgt JJ) 4~~l~ t~bfiJl
Jl jJJ ulo ~ ~ jJJ Jl ui uJJ rP ~
(YO)
(AY) uL~ J (Bronder)
JJj-3 J~- ~) U~I JJ~ L
4 UJJby ~ (Y) ~Iu tY-Jrp UJjbYo ~
~) U~l J 15J ~~I
Jl (1 ~~ (II J
J H ( 0) T 0l1li L ulo u-i~1
u~(AT) uL~
J~ ~ ---Jlr-shy
umiddotv 0
AUiI ( tJ J olS J ( AT) otJ) ( IAf) J (Morris)
J) ~
J
JJJ5
J J~I ~ts
OJJJ-iI U ~IS J)
1$ jl
1_- - )I~ + J 17 8J
(YV) ~ o~) rb J
The IOWa Stctte Univensity Press USA
20shy hrnnvl~ responses test In
hormones Am J Vet Res 49 503gt507
21 doses of 9-tJ-flunmrefiinisl3iorle acetate lM on blood 811iUIi~ serum
Sci 43 553
22shy on the eosillolphllic 1e~Yle poJ)ul8l1on of
rat tlleue I Duametbasone J of Pharmacol 189 303gt310
23 shy 1981 InJllleD=e the blood
picture of cattle Tlelranillcl1e UITiIIIhIIl11 51 2785
24 shy DP 1970 A clnicians views on the IlIIe tmd misIlIIe of phEnYll3utIIZOliIe Eq Vet J 4 63gt65
25 shy H r PM 1981
toxicosis in A ~helmlCaI Am J Vet Res 42
M 1983 Tkbullbullbull_11 nubullI1
normal
MD 1974 The effect of
26middot 1986 Textbook of anlcal ChImiddot WE saunders
27 PR and
44 1410-1418
LM 1983
28- Wanner
acetyiaiion In the hone
R 1979 A prellmlrillY
Inl MedCDrIihd Eds T Tobins JW Black tmd WE Woods LalngltonKellltud~
1shy
0
References Athens JW Boggs DR Wanner HR Cartwright GE and Wintrobe MM 1968
XiiI A noli steady state kinetic evaluation of the mechanism of cortisone induced
grllll1uJllicytgtsis J Cln 249
2shy Brlllnder GC Pugh DM ltUld B~er RJ 1982 Veterimuy Applied Pharmacology and Therapeutic
4th ed Greyecat hOUlle London England
3shy EH 1986 Veterinary Cnical PathI 4th ed WB Saunders Compo Philadelphia
4shy LG and Tyler DE 1985 ExperimentallY induced pnenylbutatooe toKicCISis in ponies
Description of the and its prevention with synthetic PGE2 Vet Res 48 1605-1615
5shy IdA~lst()ne D Mueller Heubach E and Caritis SN 1978 Effect of dexamethasone on leukocyte count
in pregnant sheep and fetalllllmbs Amer J Obst Onco 131 677-681
6shy Fauci DIllie DC and JE 1976 Glucocorlicoid of acHon and
clinical conSideration Ann Inter Med 84 309
7 shy Glade M J 1975 Chronic dexamethasone treatment to horse and pony foals Dissertation Abstract
International 41 6-7
8shy Goodman LS and A 1986 The Pharmacological Basis of a ~UIIIll 5th ed Macmillan
PubllShingCelnc New York USA
9shy Cbullbull____ DE 1983 Renal necrClSis in horses JAVMA 182 263-266
10 shy and L 1983 Renal papillary necrClSis in horses after phenylbutazone and water
deprivation Vet PllIthol 20 603-610
11 - Horrobin DF 1971 Essentillll Biochemistry Endocrinology and Nutrition MTP Com pp 86-87
12 shy Jones LM 1988 Veterinlllry Pharmacology and Therapeutics 6th ed The Iowa Stcde University
Press
13 - Kaneko JJ 1980 Clinical Biochemistry of Domestic Animals 3rd ed Academic Press Inc
New York
14 shy BG 1989 Basic and Clinical Pharmacology 4th ed Prentice Hau International (UK)
London
15 shy Creed Gerring EEL Gould PW Humphreys DJ Michell AR lind
Tayler JB 1983 Biochemical and haematologicaleffects of phenylbutazone in horses Vet J 15
158-176
16 shy Lees P and Higgins AJ 1985 Clinical pharmacology and therapeutic uses of non-steroidal
the horse Eq Vet J 17 83-96
17 shy MagnusonS KL E1978 In vitro and vivo effects
ohortioosteroids on blood lymphocytes from Am J Vet Res 39 gt1-wIo
18 shy TJ 1979 The pharmacologic interactions with laboratory test 596 Burnham
Etobiocoke Ontario Canada
19 shy Maxine M B5 1960 Outline of Veterinary Clnica Pathology_ 2nd ed pp 131-132
J No 1991
SUlLdlJ on
tn1l1amlrn2lto~ry n1lIIIInrR on 014100 J]lidule
sheep
Sa1rmldii AA
ZtllDlDlalry
In this from Veterirlaru School Animal
HulbllndilUY Unit were from 40 to
age was from 2~4 years old
blood )08tameters
Keywords
ISJJ
J
(n)
(V)
J
J
J
J J J
J
J
Y)
J
)
J --- shy
~ e-~ JI UJJ llA ~ tJJ Dtl
v~)tiT J~ ~ cP~
(YI)
~IJI JJ Dtl
vt=-6yeni JJ~~ JJI
~)rJ1 ltbh~ J
(t) f~
~I
J
J
V) ub~ J (Wanner)
~ SJ ti
J I5J~ J (0)
tS)~ Jb~ ~ JJi J
~~~o~~ Wtl s ~~ ci~ ~S
( Wo) ~r=-~
~~S (~A) uL~ J
( ~A ) u6~ J -115t(S)Jgt 4
u=t9J ~ jllJ ~~S ~ ~1 JJ
Wtl JJ 4 ~hil Wtl J 1 OIJ (A J YO) ))1 uJgtlu
~ uJlb Wtl JiIJ J ~) )I)~ ~S
~ J ) uJgtVt t(SJJgt fil
I~ uly~ ul 151Jgt ~6- J6- Jl
I 15J15tJ I5tJLI5J) Jgt UJjbYo
~p ( 15t4JfiJl
JJ-IS )iU
J rt (pltOOl) 1 ci~ ~Ijl I5Jb~
( ~A) vJ$
yJ YA 15t~1 uJe-I~1 ~Ij
(A) la~ ~S
~LS (JS uly~ Wt J
15t~j r pi Lt-~ LJ
h Jb jl JJ ~ uy 15t-~ u=t9) jl
J ti ~ r=-~ ~) utw (SJJ Wtl )
jI ~Ici~ ~S 15)~ J1~ uYJJ~ uji
~ (~A) uL~ J
~ uy)f J ~ul~ )l
- jJJ Jl UJjbYo rPJt J J)i ~ ~T
151Jgt rPJt ltgt JJ) 4~~l~ t~bfiJl
Jl jJJ ulo ~ ~ jJJ Jl ui uJJ rP ~
(YO)
(AY) uL~ J (Bronder)
JJj-3 J~- ~) U~I JJ~ L
4 UJJby ~ (Y) ~Iu tY-Jrp UJjbYo ~
~) U~l J 15J ~~I
Jl (1 ~~ (II J
J H ( 0) T 0l1li L ulo u-i~1
u~(AT) uL~
J~ ~ ---Jlr-shy
umiddotv 0
AUiI ( tJ J olS J ( AT) otJ) ( IAf) J (Morris)
J) ~
J
JJJ5
J J~I ~ts
OJJJ-iI U ~IS J)
1$ jl
1_- - )I~ + J 17 8J
(YV) ~ o~) rb J
The IOWa Stctte Univensity Press USA
20shy hrnnvl~ responses test In
hormones Am J Vet Res 49 503gt507
21 doses of 9-tJ-flunmrefiinisl3iorle acetate lM on blood 811iUIi~ serum
Sci 43 553
22shy on the eosillolphllic 1e~Yle poJ)ul8l1on of
rat tlleue I Duametbasone J of Pharmacol 189 303gt310
23 shy 1981 InJllleD=e the blood
picture of cattle Tlelranillcl1e UITiIIIhIIl11 51 2785
24 shy DP 1970 A clnicians views on the IlIIe tmd misIlIIe of phEnYll3utIIZOliIe Eq Vet J 4 63gt65
25 shy H r PM 1981
toxicosis in A ~helmlCaI Am J Vet Res 42
M 1983 Tkbullbullbull_11 nubullI1
normal
MD 1974 The effect of
26middot 1986 Textbook of anlcal ChImiddot WE saunders
27 PR and
44 1410-1418
LM 1983
28- Wanner
acetyiaiion In the hone
R 1979 A prellmlrillY
Inl MedCDrIihd Eds T Tobins JW Black tmd WE Woods LalngltonKellltud~
1shy
0
References Athens JW Boggs DR Wanner HR Cartwright GE and Wintrobe MM 1968
XiiI A noli steady state kinetic evaluation of the mechanism of cortisone induced
grllll1uJllicytgtsis J Cln 249
2shy Brlllnder GC Pugh DM ltUld B~er RJ 1982 Veterimuy Applied Pharmacology and Therapeutic
4th ed Greyecat hOUlle London England
3shy EH 1986 Veterinary Cnical PathI 4th ed WB Saunders Compo Philadelphia
4shy LG and Tyler DE 1985 ExperimentallY induced pnenylbutatooe toKicCISis in ponies
Description of the and its prevention with synthetic PGE2 Vet Res 48 1605-1615
5shy IdA~lst()ne D Mueller Heubach E and Caritis SN 1978 Effect of dexamethasone on leukocyte count
in pregnant sheep and fetalllllmbs Amer J Obst Onco 131 677-681
6shy Fauci DIllie DC and JE 1976 Glucocorlicoid of acHon and
clinical conSideration Ann Inter Med 84 309
7 shy Glade M J 1975 Chronic dexamethasone treatment to horse and pony foals Dissertation Abstract
International 41 6-7
8shy Goodman LS and A 1986 The Pharmacological Basis of a ~UIIIll 5th ed Macmillan
PubllShingCelnc New York USA
9shy Cbullbull____ DE 1983 Renal necrClSis in horses JAVMA 182 263-266
10 shy and L 1983 Renal papillary necrClSis in horses after phenylbutazone and water
deprivation Vet PllIthol 20 603-610
11 - Horrobin DF 1971 Essentillll Biochemistry Endocrinology and Nutrition MTP Com pp 86-87
12 shy Jones LM 1988 Veterinlllry Pharmacology and Therapeutics 6th ed The Iowa Stcde University
Press
13 - Kaneko JJ 1980 Clinical Biochemistry of Domestic Animals 3rd ed Academic Press Inc
New York
14 shy BG 1989 Basic and Clinical Pharmacology 4th ed Prentice Hau International (UK)
London
15 shy Creed Gerring EEL Gould PW Humphreys DJ Michell AR lind
Tayler JB 1983 Biochemical and haematologicaleffects of phenylbutazone in horses Vet J 15
158-176
16 shy Lees P and Higgins AJ 1985 Clinical pharmacology and therapeutic uses of non-steroidal
the horse Eq Vet J 17 83-96
17 shy MagnusonS KL E1978 In vitro and vivo effects
ohortioosteroids on blood lymphocytes from Am J Vet Res 39 gt1-wIo
18 shy TJ 1979 The pharmacologic interactions with laboratory test 596 Burnham
Etobiocoke Ontario Canada
19 shy Maxine M B5 1960 Outline of Veterinary Clnica Pathology_ 2nd ed pp 131-132
J No 1991
SUlLdlJ on
tn1l1amlrn2lto~ry n1lIIIInrR on 014100 J]lidule
sheep
Sa1rmldii AA
ZtllDlDlalry
In this from Veterirlaru School Animal
HulbllndilUY Unit were from 40 to
age was from 2~4 years old
blood )08tameters
Keywords
J J J
J
J
Y)
J
)
J --- shy
~ e-~ JI UJJ llA ~ tJJ Dtl
v~)tiT J~ ~ cP~
(YI)
~IJI JJ Dtl
vt=-6yeni JJ~~ JJI
~)rJ1 ltbh~ J
(t) f~
~I
J
J
V) ub~ J (Wanner)
~ SJ ti
J I5J~ J (0)
tS)~ Jb~ ~ JJi J
~~~o~~ Wtl s ~~ ci~ ~S
( Wo) ~r=-~
~~S (~A) uL~ J
( ~A ) u6~ J -115t(S)Jgt 4
u=t9J ~ jllJ ~~S ~ ~1 JJ
Wtl JJ 4 ~hil Wtl J 1 OIJ (A J YO) ))1 uJgtlu
~ uJlb Wtl JiIJ J ~) )I)~ ~S
~ J ) uJgtVt t(SJJgt fil
I~ uly~ ul 151Jgt ~6- J6- Jl
I 15J15tJ I5tJLI5J) Jgt UJjbYo
~p ( 15t4JfiJl
JJ-IS )iU
J rt (pltOOl) 1 ci~ ~Ijl I5Jb~
( ~A) vJ$
yJ YA 15t~1 uJe-I~1 ~Ij
(A) la~ ~S
~LS (JS uly~ Wt J
15t~j r pi Lt-~ LJ
h Jb jl JJ ~ uy 15t-~ u=t9) jl
J ti ~ r=-~ ~) utw (SJJ Wtl )
jI ~Ici~ ~S 15)~ J1~ uYJJ~ uji
~ (~A) uL~ J
~ uy)f J ~ul~ )l
- jJJ Jl UJjbYo rPJt J J)i ~ ~T
151Jgt rPJt ltgt JJ) 4~~l~ t~bfiJl
Jl jJJ ulo ~ ~ jJJ Jl ui uJJ rP ~
(YO)
(AY) uL~ J (Bronder)
JJj-3 J~- ~) U~I JJ~ L
4 UJJby ~ (Y) ~Iu tY-Jrp UJjbYo ~
~) U~l J 15J ~~I
Jl (1 ~~ (II J
J H ( 0) T 0l1li L ulo u-i~1
u~(AT) uL~
J~ ~ ---Jlr-shy
umiddotv 0
AUiI ( tJ J olS J ( AT) otJ) ( IAf) J (Morris)
J) ~
J
JJJ5
J J~I ~ts
OJJJ-iI U ~IS J)
1$ jl
1_- - )I~ + J 17 8J
(YV) ~ o~) rb J
The IOWa Stctte Univensity Press USA
20shy hrnnvl~ responses test In
hormones Am J Vet Res 49 503gt507
21 doses of 9-tJ-flunmrefiinisl3iorle acetate lM on blood 811iUIi~ serum
Sci 43 553
22shy on the eosillolphllic 1e~Yle poJ)ul8l1on of
rat tlleue I Duametbasone J of Pharmacol 189 303gt310
23 shy 1981 InJllleD=e the blood
picture of cattle Tlelranillcl1e UITiIIIhIIl11 51 2785
24 shy DP 1970 A clnicians views on the IlIIe tmd misIlIIe of phEnYll3utIIZOliIe Eq Vet J 4 63gt65
25 shy H r PM 1981
toxicosis in A ~helmlCaI Am J Vet Res 42
M 1983 Tkbullbullbull_11 nubullI1
normal
MD 1974 The effect of
26middot 1986 Textbook of anlcal ChImiddot WE saunders
27 PR and
44 1410-1418
LM 1983
28- Wanner
acetyiaiion In the hone
R 1979 A prellmlrillY
Inl MedCDrIihd Eds T Tobins JW Black tmd WE Woods LalngltonKellltud~
1shy
0
References Athens JW Boggs DR Wanner HR Cartwright GE and Wintrobe MM 1968
XiiI A noli steady state kinetic evaluation of the mechanism of cortisone induced
grllll1uJllicytgtsis J Cln 249
2shy Brlllnder GC Pugh DM ltUld B~er RJ 1982 Veterimuy Applied Pharmacology and Therapeutic
4th ed Greyecat hOUlle London England
3shy EH 1986 Veterinary Cnical PathI 4th ed WB Saunders Compo Philadelphia
4shy LG and Tyler DE 1985 ExperimentallY induced pnenylbutatooe toKicCISis in ponies
Description of the and its prevention with synthetic PGE2 Vet Res 48 1605-1615
5shy IdA~lst()ne D Mueller Heubach E and Caritis SN 1978 Effect of dexamethasone on leukocyte count
in pregnant sheep and fetalllllmbs Amer J Obst Onco 131 677-681
6shy Fauci DIllie DC and JE 1976 Glucocorlicoid of acHon and
clinical conSideration Ann Inter Med 84 309
7 shy Glade M J 1975 Chronic dexamethasone treatment to horse and pony foals Dissertation Abstract
International 41 6-7
8shy Goodman LS and A 1986 The Pharmacological Basis of a ~UIIIll 5th ed Macmillan
PubllShingCelnc New York USA
9shy Cbullbull____ DE 1983 Renal necrClSis in horses JAVMA 182 263-266
10 shy and L 1983 Renal papillary necrClSis in horses after phenylbutazone and water
deprivation Vet PllIthol 20 603-610
11 - Horrobin DF 1971 Essentillll Biochemistry Endocrinology and Nutrition MTP Com pp 86-87
12 shy Jones LM 1988 Veterinlllry Pharmacology and Therapeutics 6th ed The Iowa Stcde University
Press
13 - Kaneko JJ 1980 Clinical Biochemistry of Domestic Animals 3rd ed Academic Press Inc
New York
14 shy BG 1989 Basic and Clinical Pharmacology 4th ed Prentice Hau International (UK)
London
15 shy Creed Gerring EEL Gould PW Humphreys DJ Michell AR lind
Tayler JB 1983 Biochemical and haematologicaleffects of phenylbutazone in horses Vet J 15
158-176
16 shy Lees P and Higgins AJ 1985 Clinical pharmacology and therapeutic uses of non-steroidal
the horse Eq Vet J 17 83-96
17 shy MagnusonS KL E1978 In vitro and vivo effects
ohortioosteroids on blood lymphocytes from Am J Vet Res 39 gt1-wIo
18 shy TJ 1979 The pharmacologic interactions with laboratory test 596 Burnham
Etobiocoke Ontario Canada
19 shy Maxine M B5 1960 Outline of Veterinary Clnica Pathology_ 2nd ed pp 131-132
J No 1991
SUlLdlJ on
tn1l1amlrn2lto~ry n1lIIIInrR on 014100 J]lidule
sheep
Sa1rmldii AA
ZtllDlDlalry
In this from Veterirlaru School Animal
HulbllndilUY Unit were from 40 to
age was from 2~4 years old
blood )08tameters
Keywords
J --- shy
~ e-~ JI UJJ llA ~ tJJ Dtl
v~)tiT J~ ~ cP~
(YI)
~IJI JJ Dtl
vt=-6yeni JJ~~ JJI
~)rJ1 ltbh~ J
(t) f~
~I
J
J
V) ub~ J (Wanner)
~ SJ ti
J I5J~ J (0)
tS)~ Jb~ ~ JJi J
~~~o~~ Wtl s ~~ ci~ ~S
( Wo) ~r=-~
~~S (~A) uL~ J
( ~A ) u6~ J -115t(S)Jgt 4
u=t9J ~ jllJ ~~S ~ ~1 JJ
Wtl JJ 4 ~hil Wtl J 1 OIJ (A J YO) ))1 uJgtlu
~ uJlb Wtl JiIJ J ~) )I)~ ~S
~ J ) uJgtVt t(SJJgt fil
I~ uly~ ul 151Jgt ~6- J6- Jl
I 15J15tJ I5tJLI5J) Jgt UJjbYo
~p ( 15t4JfiJl
JJ-IS )iU
J rt (pltOOl) 1 ci~ ~Ijl I5Jb~
( ~A) vJ$
yJ YA 15t~1 uJe-I~1 ~Ij
(A) la~ ~S
~LS (JS uly~ Wt J
15t~j r pi Lt-~ LJ
h Jb jl JJ ~ uy 15t-~ u=t9) jl
J ti ~ r=-~ ~) utw (SJJ Wtl )
jI ~Ici~ ~S 15)~ J1~ uYJJ~ uji
~ (~A) uL~ J
~ uy)f J ~ul~ )l
- jJJ Jl UJjbYo rPJt J J)i ~ ~T
151Jgt rPJt ltgt JJ) 4~~l~ t~bfiJl
Jl jJJ ulo ~ ~ jJJ Jl ui uJJ rP ~
(YO)
(AY) uL~ J (Bronder)
JJj-3 J~- ~) U~I JJ~ L
4 UJJby ~ (Y) ~Iu tY-Jrp UJjbYo ~
~) U~l J 15J ~~I
Jl (1 ~~ (II J
J H ( 0) T 0l1li L ulo u-i~1
u~(AT) uL~
J~ ~ ---Jlr-shy
umiddotv 0
AUiI ( tJ J olS J ( AT) otJ) ( IAf) J (Morris)
J) ~
J
JJJ5
J J~I ~ts
OJJJ-iI U ~IS J)
1$ jl
1_- - )I~ + J 17 8J
(YV) ~ o~) rb J
The IOWa Stctte Univensity Press USA
20shy hrnnvl~ responses test In
hormones Am J Vet Res 49 503gt507
21 doses of 9-tJ-flunmrefiinisl3iorle acetate lM on blood 811iUIi~ serum
Sci 43 553
22shy on the eosillolphllic 1e~Yle poJ)ul8l1on of
rat tlleue I Duametbasone J of Pharmacol 189 303gt310
23 shy 1981 InJllleD=e the blood
picture of cattle Tlelranillcl1e UITiIIIhIIl11 51 2785
24 shy DP 1970 A clnicians views on the IlIIe tmd misIlIIe of phEnYll3utIIZOliIe Eq Vet J 4 63gt65
25 shy H r PM 1981
toxicosis in A ~helmlCaI Am J Vet Res 42
M 1983 Tkbullbullbull_11 nubullI1
normal
MD 1974 The effect of
26middot 1986 Textbook of anlcal ChImiddot WE saunders
27 PR and
44 1410-1418
LM 1983
28- Wanner
acetyiaiion In the hone
R 1979 A prellmlrillY
Inl MedCDrIihd Eds T Tobins JW Black tmd WE Woods LalngltonKellltud~
1shy
0
References Athens JW Boggs DR Wanner HR Cartwright GE and Wintrobe MM 1968
XiiI A noli steady state kinetic evaluation of the mechanism of cortisone induced
grllll1uJllicytgtsis J Cln 249
2shy Brlllnder GC Pugh DM ltUld B~er RJ 1982 Veterimuy Applied Pharmacology and Therapeutic
4th ed Greyecat hOUlle London England
3shy EH 1986 Veterinary Cnical PathI 4th ed WB Saunders Compo Philadelphia
4shy LG and Tyler DE 1985 ExperimentallY induced pnenylbutatooe toKicCISis in ponies
Description of the and its prevention with synthetic PGE2 Vet Res 48 1605-1615
5shy IdA~lst()ne D Mueller Heubach E and Caritis SN 1978 Effect of dexamethasone on leukocyte count
in pregnant sheep and fetalllllmbs Amer J Obst Onco 131 677-681
6shy Fauci DIllie DC and JE 1976 Glucocorlicoid of acHon and
clinical conSideration Ann Inter Med 84 309
7 shy Glade M J 1975 Chronic dexamethasone treatment to horse and pony foals Dissertation Abstract
International 41 6-7
8shy Goodman LS and A 1986 The Pharmacological Basis of a ~UIIIll 5th ed Macmillan
PubllShingCelnc New York USA
9shy Cbullbull____ DE 1983 Renal necrClSis in horses JAVMA 182 263-266
10 shy and L 1983 Renal papillary necrClSis in horses after phenylbutazone and water
deprivation Vet PllIthol 20 603-610
11 - Horrobin DF 1971 Essentillll Biochemistry Endocrinology and Nutrition MTP Com pp 86-87
12 shy Jones LM 1988 Veterinlllry Pharmacology and Therapeutics 6th ed The Iowa Stcde University
Press
13 - Kaneko JJ 1980 Clinical Biochemistry of Domestic Animals 3rd ed Academic Press Inc
New York
14 shy BG 1989 Basic and Clinical Pharmacology 4th ed Prentice Hau International (UK)
London
15 shy Creed Gerring EEL Gould PW Humphreys DJ Michell AR lind
Tayler JB 1983 Biochemical and haematologicaleffects of phenylbutazone in horses Vet J 15
158-176
16 shy Lees P and Higgins AJ 1985 Clinical pharmacology and therapeutic uses of non-steroidal
the horse Eq Vet J 17 83-96
17 shy MagnusonS KL E1978 In vitro and vivo effects
ohortioosteroids on blood lymphocytes from Am J Vet Res 39 gt1-wIo
18 shy TJ 1979 The pharmacologic interactions with laboratory test 596 Burnham
Etobiocoke Ontario Canada
19 shy Maxine M B5 1960 Outline of Veterinary Clnica Pathology_ 2nd ed pp 131-132
J No 1991
SUlLdlJ on
tn1l1amlrn2lto~ry n1lIIIInrR on 014100 J]lidule
sheep
Sa1rmldii AA
ZtllDlDlalry
In this from Veterirlaru School Animal
HulbllndilUY Unit were from 40 to
age was from 2~4 years old
blood )08tameters
Keywords
~I
J
J
V) ub~ J (Wanner)
~ SJ ti
J I5J~ J (0)
tS)~ Jb~ ~ JJi J
~~~o~~ Wtl s ~~ ci~ ~S
( Wo) ~r=-~
~~S (~A) uL~ J
( ~A ) u6~ J -115t(S)Jgt 4
u=t9J ~ jllJ ~~S ~ ~1 JJ
Wtl JJ 4 ~hil Wtl J 1 OIJ (A J YO) ))1 uJgtlu
~ uJlb Wtl JiIJ J ~) )I)~ ~S
~ J ) uJgtVt t(SJJgt fil
I~ uly~ ul 151Jgt ~6- J6- Jl
I 15J15tJ I5tJLI5J) Jgt UJjbYo
~p ( 15t4JfiJl
JJ-IS )iU
J rt (pltOOl) 1 ci~ ~Ijl I5Jb~
( ~A) vJ$
yJ YA 15t~1 uJe-I~1 ~Ij
(A) la~ ~S
~LS (JS uly~ Wt J
15t~j r pi Lt-~ LJ
h Jb jl JJ ~ uy 15t-~ u=t9) jl
J ti ~ r=-~ ~) utw (SJJ Wtl )
jI ~Ici~ ~S 15)~ J1~ uYJJ~ uji
~ (~A) uL~ J
~ uy)f J ~ul~ )l
- jJJ Jl UJjbYo rPJt J J)i ~ ~T
151Jgt rPJt ltgt JJ) 4~~l~ t~bfiJl
Jl jJJ ulo ~ ~ jJJ Jl ui uJJ rP ~
(YO)
(AY) uL~ J (Bronder)
JJj-3 J~- ~) U~I JJ~ L
4 UJJby ~ (Y) ~Iu tY-Jrp UJjbYo ~
~) U~l J 15J ~~I
Jl (1 ~~ (II J
J H ( 0) T 0l1li L ulo u-i~1
u~(AT) uL~
J~ ~ ---Jlr-shy
umiddotv 0
AUiI ( tJ J olS J ( AT) otJ) ( IAf) J (Morris)
J) ~
J
JJJ5
J J~I ~ts
OJJJ-iI U ~IS J)
1$ jl
1_- - )I~ + J 17 8J
(YV) ~ o~) rb J
The IOWa Stctte Univensity Press USA
20shy hrnnvl~ responses test In
hormones Am J Vet Res 49 503gt507
21 doses of 9-tJ-flunmrefiinisl3iorle acetate lM on blood 811iUIi~ serum
Sci 43 553
22shy on the eosillolphllic 1e~Yle poJ)ul8l1on of
rat tlleue I Duametbasone J of Pharmacol 189 303gt310
23 shy 1981 InJllleD=e the blood
picture of cattle Tlelranillcl1e UITiIIIhIIl11 51 2785
24 shy DP 1970 A clnicians views on the IlIIe tmd misIlIIe of phEnYll3utIIZOliIe Eq Vet J 4 63gt65
25 shy H r PM 1981
toxicosis in A ~helmlCaI Am J Vet Res 42
M 1983 Tkbullbullbull_11 nubullI1
normal
MD 1974 The effect of
26middot 1986 Textbook of anlcal ChImiddot WE saunders
27 PR and
44 1410-1418
LM 1983
28- Wanner
acetyiaiion In the hone
R 1979 A prellmlrillY
Inl MedCDrIihd Eds T Tobins JW Black tmd WE Woods LalngltonKellltud~
1shy
0
References Athens JW Boggs DR Wanner HR Cartwright GE and Wintrobe MM 1968
XiiI A noli steady state kinetic evaluation of the mechanism of cortisone induced
grllll1uJllicytgtsis J Cln 249
2shy Brlllnder GC Pugh DM ltUld B~er RJ 1982 Veterimuy Applied Pharmacology and Therapeutic
4th ed Greyecat hOUlle London England
3shy EH 1986 Veterinary Cnical PathI 4th ed WB Saunders Compo Philadelphia
4shy LG and Tyler DE 1985 ExperimentallY induced pnenylbutatooe toKicCISis in ponies
Description of the and its prevention with synthetic PGE2 Vet Res 48 1605-1615
5shy IdA~lst()ne D Mueller Heubach E and Caritis SN 1978 Effect of dexamethasone on leukocyte count
in pregnant sheep and fetalllllmbs Amer J Obst Onco 131 677-681
6shy Fauci DIllie DC and JE 1976 Glucocorlicoid of acHon and
clinical conSideration Ann Inter Med 84 309
7 shy Glade M J 1975 Chronic dexamethasone treatment to horse and pony foals Dissertation Abstract
International 41 6-7
8shy Goodman LS and A 1986 The Pharmacological Basis of a ~UIIIll 5th ed Macmillan
PubllShingCelnc New York USA
9shy Cbullbull____ DE 1983 Renal necrClSis in horses JAVMA 182 263-266
10 shy and L 1983 Renal papillary necrClSis in horses after phenylbutazone and water
deprivation Vet PllIthol 20 603-610
11 - Horrobin DF 1971 Essentillll Biochemistry Endocrinology and Nutrition MTP Com pp 86-87
12 shy Jones LM 1988 Veterinlllry Pharmacology and Therapeutics 6th ed The Iowa Stcde University
Press
13 - Kaneko JJ 1980 Clinical Biochemistry of Domestic Animals 3rd ed Academic Press Inc
New York
14 shy BG 1989 Basic and Clinical Pharmacology 4th ed Prentice Hau International (UK)
London
15 shy Creed Gerring EEL Gould PW Humphreys DJ Michell AR lind
Tayler JB 1983 Biochemical and haematologicaleffects of phenylbutazone in horses Vet J 15
158-176
16 shy Lees P and Higgins AJ 1985 Clinical pharmacology and therapeutic uses of non-steroidal
the horse Eq Vet J 17 83-96
17 shy MagnusonS KL E1978 In vitro and vivo effects
ohortioosteroids on blood lymphocytes from Am J Vet Res 39 gt1-wIo
18 shy TJ 1979 The pharmacologic interactions with laboratory test 596 Burnham
Etobiocoke Ontario Canada
19 shy Maxine M B5 1960 Outline of Veterinary Clnica Pathology_ 2nd ed pp 131-132
J No 1991
SUlLdlJ on
tn1l1amlrn2lto~ry n1lIIIInrR on 014100 J]lidule
sheep
Sa1rmldii AA
ZtllDlDlalry
In this from Veterirlaru School Animal
HulbllndilUY Unit were from 40 to
age was from 2~4 years old
blood )08tameters
Keywords
~ SJ ti
J I5J~ J (0)
tS)~ Jb~ ~ JJi J
~~~o~~ Wtl s ~~ ci~ ~S
( Wo) ~r=-~
~~S (~A) uL~ J
( ~A ) u6~ J -115t(S)Jgt 4
u=t9J ~ jllJ ~~S ~ ~1 JJ
Wtl JJ 4 ~hil Wtl J 1 OIJ (A J YO) ))1 uJgtlu
~ uJlb Wtl JiIJ J ~) )I)~ ~S
~ J ) uJgtVt t(SJJgt fil
I~ uly~ ul 151Jgt ~6- J6- Jl
I 15J15tJ I5tJLI5J) Jgt UJjbYo
~p ( 15t4JfiJl
JJ-IS )iU
J rt (pltOOl) 1 ci~ ~Ijl I5Jb~
( ~A) vJ$
yJ YA 15t~1 uJe-I~1 ~Ij
(A) la~ ~S
~LS (JS uly~ Wt J
15t~j r pi Lt-~ LJ
h Jb jl JJ ~ uy 15t-~ u=t9) jl
J ti ~ r=-~ ~) utw (SJJ Wtl )
jI ~Ici~ ~S 15)~ J1~ uYJJ~ uji
~ (~A) uL~ J
~ uy)f J ~ul~ )l
- jJJ Jl UJjbYo rPJt J J)i ~ ~T
151Jgt rPJt ltgt JJ) 4~~l~ t~bfiJl
Jl jJJ ulo ~ ~ jJJ Jl ui uJJ rP ~
(YO)
(AY) uL~ J (Bronder)
JJj-3 J~- ~) U~I JJ~ L
4 UJJby ~ (Y) ~Iu tY-Jrp UJjbYo ~
~) U~l J 15J ~~I
Jl (1 ~~ (II J
J H ( 0) T 0l1li L ulo u-i~1
u~(AT) uL~
J~ ~ ---Jlr-shy
umiddotv 0
AUiI ( tJ J olS J ( AT) otJ) ( IAf) J (Morris)
J) ~
J
JJJ5
J J~I ~ts
OJJJ-iI U ~IS J)
1$ jl
1_- - )I~ + J 17 8J
(YV) ~ o~) rb J
The IOWa Stctte Univensity Press USA
20shy hrnnvl~ responses test In
hormones Am J Vet Res 49 503gt507
21 doses of 9-tJ-flunmrefiinisl3iorle acetate lM on blood 811iUIi~ serum
Sci 43 553
22shy on the eosillolphllic 1e~Yle poJ)ul8l1on of
rat tlleue I Duametbasone J of Pharmacol 189 303gt310
23 shy 1981 InJllleD=e the blood
picture of cattle Tlelranillcl1e UITiIIIhIIl11 51 2785
24 shy DP 1970 A clnicians views on the IlIIe tmd misIlIIe of phEnYll3utIIZOliIe Eq Vet J 4 63gt65
25 shy H r PM 1981
toxicosis in A ~helmlCaI Am J Vet Res 42
M 1983 Tkbullbullbull_11 nubullI1
normal
MD 1974 The effect of
26middot 1986 Textbook of anlcal ChImiddot WE saunders
27 PR and
44 1410-1418
LM 1983
28- Wanner
acetyiaiion In the hone
R 1979 A prellmlrillY
Inl MedCDrIihd Eds T Tobins JW Black tmd WE Woods LalngltonKellltud~
1shy
0
References Athens JW Boggs DR Wanner HR Cartwright GE and Wintrobe MM 1968
XiiI A noli steady state kinetic evaluation of the mechanism of cortisone induced
grllll1uJllicytgtsis J Cln 249
2shy Brlllnder GC Pugh DM ltUld B~er RJ 1982 Veterimuy Applied Pharmacology and Therapeutic
4th ed Greyecat hOUlle London England
3shy EH 1986 Veterinary Cnical PathI 4th ed WB Saunders Compo Philadelphia
4shy LG and Tyler DE 1985 ExperimentallY induced pnenylbutatooe toKicCISis in ponies
Description of the and its prevention with synthetic PGE2 Vet Res 48 1605-1615
5shy IdA~lst()ne D Mueller Heubach E and Caritis SN 1978 Effect of dexamethasone on leukocyte count
in pregnant sheep and fetalllllmbs Amer J Obst Onco 131 677-681
6shy Fauci DIllie DC and JE 1976 Glucocorlicoid of acHon and
clinical conSideration Ann Inter Med 84 309
7 shy Glade M J 1975 Chronic dexamethasone treatment to horse and pony foals Dissertation Abstract
International 41 6-7
8shy Goodman LS and A 1986 The Pharmacological Basis of a ~UIIIll 5th ed Macmillan
PubllShingCelnc New York USA
9shy Cbullbull____ DE 1983 Renal necrClSis in horses JAVMA 182 263-266
10 shy and L 1983 Renal papillary necrClSis in horses after phenylbutazone and water
deprivation Vet PllIthol 20 603-610
11 - Horrobin DF 1971 Essentillll Biochemistry Endocrinology and Nutrition MTP Com pp 86-87
12 shy Jones LM 1988 Veterinlllry Pharmacology and Therapeutics 6th ed The Iowa Stcde University
Press
13 - Kaneko JJ 1980 Clinical Biochemistry of Domestic Animals 3rd ed Academic Press Inc
New York
14 shy BG 1989 Basic and Clinical Pharmacology 4th ed Prentice Hau International (UK)
London
15 shy Creed Gerring EEL Gould PW Humphreys DJ Michell AR lind
Tayler JB 1983 Biochemical and haematologicaleffects of phenylbutazone in horses Vet J 15
158-176
16 shy Lees P and Higgins AJ 1985 Clinical pharmacology and therapeutic uses of non-steroidal
the horse Eq Vet J 17 83-96
17 shy MagnusonS KL E1978 In vitro and vivo effects
ohortioosteroids on blood lymphocytes from Am J Vet Res 39 gt1-wIo
18 shy TJ 1979 The pharmacologic interactions with laboratory test 596 Burnham
Etobiocoke Ontario Canada
19 shy Maxine M B5 1960 Outline of Veterinary Clnica Pathology_ 2nd ed pp 131-132
J No 1991
SUlLdlJ on
tn1l1amlrn2lto~ry n1lIIIInrR on 014100 J]lidule
sheep
Sa1rmldii AA
ZtllDlDlalry
In this from Veterirlaru School Animal
HulbllndilUY Unit were from 40 to
age was from 2~4 years old
blood )08tameters
Keywords
umiddotv 0
AUiI ( tJ J olS J ( AT) otJ) ( IAf) J (Morris)
J) ~
J
JJJ5
J J~I ~ts
OJJJ-iI U ~IS J)
1$ jl
1_- - )I~ + J 17 8J
(YV) ~ o~) rb J
The IOWa Stctte Univensity Press USA
20shy hrnnvl~ responses test In
hormones Am J Vet Res 49 503gt507
21 doses of 9-tJ-flunmrefiinisl3iorle acetate lM on blood 811iUIi~ serum
Sci 43 553
22shy on the eosillolphllic 1e~Yle poJ)ul8l1on of
rat tlleue I Duametbasone J of Pharmacol 189 303gt310
23 shy 1981 InJllleD=e the blood
picture of cattle Tlelranillcl1e UITiIIIhIIl11 51 2785
24 shy DP 1970 A clnicians views on the IlIIe tmd misIlIIe of phEnYll3utIIZOliIe Eq Vet J 4 63gt65
25 shy H r PM 1981
toxicosis in A ~helmlCaI Am J Vet Res 42
M 1983 Tkbullbullbull_11 nubullI1
normal
MD 1974 The effect of
26middot 1986 Textbook of anlcal ChImiddot WE saunders
27 PR and
44 1410-1418
LM 1983
28- Wanner
acetyiaiion In the hone
R 1979 A prellmlrillY
Inl MedCDrIihd Eds T Tobins JW Black tmd WE Woods LalngltonKellltud~
1shy
0
References Athens JW Boggs DR Wanner HR Cartwright GE and Wintrobe MM 1968
XiiI A noli steady state kinetic evaluation of the mechanism of cortisone induced
grllll1uJllicytgtsis J Cln 249
2shy Brlllnder GC Pugh DM ltUld B~er RJ 1982 Veterimuy Applied Pharmacology and Therapeutic
4th ed Greyecat hOUlle London England
3shy EH 1986 Veterinary Cnical PathI 4th ed WB Saunders Compo Philadelphia
4shy LG and Tyler DE 1985 ExperimentallY induced pnenylbutatooe toKicCISis in ponies
Description of the and its prevention with synthetic PGE2 Vet Res 48 1605-1615
5shy IdA~lst()ne D Mueller Heubach E and Caritis SN 1978 Effect of dexamethasone on leukocyte count
in pregnant sheep and fetalllllmbs Amer J Obst Onco 131 677-681
6shy Fauci DIllie DC and JE 1976 Glucocorlicoid of acHon and
clinical conSideration Ann Inter Med 84 309
7 shy Glade M J 1975 Chronic dexamethasone treatment to horse and pony foals Dissertation Abstract
International 41 6-7
8shy Goodman LS and A 1986 The Pharmacological Basis of a ~UIIIll 5th ed Macmillan
PubllShingCelnc New York USA
9shy Cbullbull____ DE 1983 Renal necrClSis in horses JAVMA 182 263-266
10 shy and L 1983 Renal papillary necrClSis in horses after phenylbutazone and water
deprivation Vet PllIthol 20 603-610
11 - Horrobin DF 1971 Essentillll Biochemistry Endocrinology and Nutrition MTP Com pp 86-87
12 shy Jones LM 1988 Veterinlllry Pharmacology and Therapeutics 6th ed The Iowa Stcde University
Press
13 - Kaneko JJ 1980 Clinical Biochemistry of Domestic Animals 3rd ed Academic Press Inc
New York
14 shy BG 1989 Basic and Clinical Pharmacology 4th ed Prentice Hau International (UK)
London
15 shy Creed Gerring EEL Gould PW Humphreys DJ Michell AR lind
Tayler JB 1983 Biochemical and haematologicaleffects of phenylbutazone in horses Vet J 15
158-176
16 shy Lees P and Higgins AJ 1985 Clinical pharmacology and therapeutic uses of non-steroidal
the horse Eq Vet J 17 83-96
17 shy MagnusonS KL E1978 In vitro and vivo effects
ohortioosteroids on blood lymphocytes from Am J Vet Res 39 gt1-wIo
18 shy TJ 1979 The pharmacologic interactions with laboratory test 596 Burnham
Etobiocoke Ontario Canada
19 shy Maxine M B5 1960 Outline of Veterinary Clnica Pathology_ 2nd ed pp 131-132
J No 1991
SUlLdlJ on
tn1l1amlrn2lto~ry n1lIIIInrR on 014100 J]lidule
sheep
Sa1rmldii AA
ZtllDlDlalry
In this from Veterirlaru School Animal
HulbllndilUY Unit were from 40 to
age was from 2~4 years old
blood )08tameters
Keywords
The IOWa Stctte Univensity Press USA
20shy hrnnvl~ responses test In
hormones Am J Vet Res 49 503gt507
21 doses of 9-tJ-flunmrefiinisl3iorle acetate lM on blood 811iUIi~ serum
Sci 43 553
22shy on the eosillolphllic 1e~Yle poJ)ul8l1on of
rat tlleue I Duametbasone J of Pharmacol 189 303gt310
23 shy 1981 InJllleD=e the blood
picture of cattle Tlelranillcl1e UITiIIIhIIl11 51 2785
24 shy DP 1970 A clnicians views on the IlIIe tmd misIlIIe of phEnYll3utIIZOliIe Eq Vet J 4 63gt65
25 shy H r PM 1981
toxicosis in A ~helmlCaI Am J Vet Res 42
M 1983 Tkbullbullbull_11 nubullI1
normal
MD 1974 The effect of
26middot 1986 Textbook of anlcal ChImiddot WE saunders
27 PR and
44 1410-1418
LM 1983
28- Wanner
acetyiaiion In the hone
R 1979 A prellmlrillY
Inl MedCDrIihd Eds T Tobins JW Black tmd WE Woods LalngltonKellltud~
1shy
0
References Athens JW Boggs DR Wanner HR Cartwright GE and Wintrobe MM 1968
XiiI A noli steady state kinetic evaluation of the mechanism of cortisone induced
grllll1uJllicytgtsis J Cln 249
2shy Brlllnder GC Pugh DM ltUld B~er RJ 1982 Veterimuy Applied Pharmacology and Therapeutic
4th ed Greyecat hOUlle London England
3shy EH 1986 Veterinary Cnical PathI 4th ed WB Saunders Compo Philadelphia
4shy LG and Tyler DE 1985 ExperimentallY induced pnenylbutatooe toKicCISis in ponies
Description of the and its prevention with synthetic PGE2 Vet Res 48 1605-1615
5shy IdA~lst()ne D Mueller Heubach E and Caritis SN 1978 Effect of dexamethasone on leukocyte count
in pregnant sheep and fetalllllmbs Amer J Obst Onco 131 677-681
6shy Fauci DIllie DC and JE 1976 Glucocorlicoid of acHon and
clinical conSideration Ann Inter Med 84 309
7 shy Glade M J 1975 Chronic dexamethasone treatment to horse and pony foals Dissertation Abstract
International 41 6-7
8shy Goodman LS and A 1986 The Pharmacological Basis of a ~UIIIll 5th ed Macmillan
PubllShingCelnc New York USA
9shy Cbullbull____ DE 1983 Renal necrClSis in horses JAVMA 182 263-266
10 shy and L 1983 Renal papillary necrClSis in horses after phenylbutazone and water
deprivation Vet PllIthol 20 603-610
11 - Horrobin DF 1971 Essentillll Biochemistry Endocrinology and Nutrition MTP Com pp 86-87
12 shy Jones LM 1988 Veterinlllry Pharmacology and Therapeutics 6th ed The Iowa Stcde University
Press
13 - Kaneko JJ 1980 Clinical Biochemistry of Domestic Animals 3rd ed Academic Press Inc
New York
14 shy BG 1989 Basic and Clinical Pharmacology 4th ed Prentice Hau International (UK)
London
15 shy Creed Gerring EEL Gould PW Humphreys DJ Michell AR lind
Tayler JB 1983 Biochemical and haematologicaleffects of phenylbutazone in horses Vet J 15
158-176
16 shy Lees P and Higgins AJ 1985 Clinical pharmacology and therapeutic uses of non-steroidal
the horse Eq Vet J 17 83-96
17 shy MagnusonS KL E1978 In vitro and vivo effects
ohortioosteroids on blood lymphocytes from Am J Vet Res 39 gt1-wIo
18 shy TJ 1979 The pharmacologic interactions with laboratory test 596 Burnham
Etobiocoke Ontario Canada
19 shy Maxine M B5 1960 Outline of Veterinary Clnica Pathology_ 2nd ed pp 131-132
J No 1991
SUlLdlJ on
tn1l1amlrn2lto~ry n1lIIIInrR on 014100 J]lidule
sheep
Sa1rmldii AA
ZtllDlDlalry
In this from Veterirlaru School Animal
HulbllndilUY Unit were from 40 to
age was from 2~4 years old
blood )08tameters
Keywords
1shy
0
References Athens JW Boggs DR Wanner HR Cartwright GE and Wintrobe MM 1968
XiiI A noli steady state kinetic evaluation of the mechanism of cortisone induced
grllll1uJllicytgtsis J Cln 249
2shy Brlllnder GC Pugh DM ltUld B~er RJ 1982 Veterimuy Applied Pharmacology and Therapeutic
4th ed Greyecat hOUlle London England
3shy EH 1986 Veterinary Cnical PathI 4th ed WB Saunders Compo Philadelphia
4shy LG and Tyler DE 1985 ExperimentallY induced pnenylbutatooe toKicCISis in ponies
Description of the and its prevention with synthetic PGE2 Vet Res 48 1605-1615
5shy IdA~lst()ne D Mueller Heubach E and Caritis SN 1978 Effect of dexamethasone on leukocyte count
in pregnant sheep and fetalllllmbs Amer J Obst Onco 131 677-681
6shy Fauci DIllie DC and JE 1976 Glucocorlicoid of acHon and
clinical conSideration Ann Inter Med 84 309
7 shy Glade M J 1975 Chronic dexamethasone treatment to horse and pony foals Dissertation Abstract
International 41 6-7
8shy Goodman LS and A 1986 The Pharmacological Basis of a ~UIIIll 5th ed Macmillan
PubllShingCelnc New York USA
9shy Cbullbull____ DE 1983 Renal necrClSis in horses JAVMA 182 263-266
10 shy and L 1983 Renal papillary necrClSis in horses after phenylbutazone and water
deprivation Vet PllIthol 20 603-610
11 - Horrobin DF 1971 Essentillll Biochemistry Endocrinology and Nutrition MTP Com pp 86-87
12 shy Jones LM 1988 Veterinlllry Pharmacology and Therapeutics 6th ed The Iowa Stcde University
Press
13 - Kaneko JJ 1980 Clinical Biochemistry of Domestic Animals 3rd ed Academic Press Inc
New York
14 shy BG 1989 Basic and Clinical Pharmacology 4th ed Prentice Hau International (UK)
London
15 shy Creed Gerring EEL Gould PW Humphreys DJ Michell AR lind
Tayler JB 1983 Biochemical and haematologicaleffects of phenylbutazone in horses Vet J 15
158-176
16 shy Lees P and Higgins AJ 1985 Clinical pharmacology and therapeutic uses of non-steroidal
the horse Eq Vet J 17 83-96
17 shy MagnusonS KL E1978 In vitro and vivo effects
ohortioosteroids on blood lymphocytes from Am J Vet Res 39 gt1-wIo
18 shy TJ 1979 The pharmacologic interactions with laboratory test 596 Burnham
Etobiocoke Ontario Canada
19 shy Maxine M B5 1960 Outline of Veterinary Clnica Pathology_ 2nd ed pp 131-132
J No 1991
SUlLdlJ on
tn1l1amlrn2lto~ry n1lIIIInrR on 014100 J]lidule
sheep
Sa1rmldii AA
ZtllDlDlalry
In this from Veterirlaru School Animal
HulbllndilUY Unit were from 40 to
age was from 2~4 years old
blood )08tameters
Keywords
J No 1991
SUlLdlJ on
tn1l1amlrn2lto~ry n1lIIIInrR on 014100 J]lidule
sheep
Sa1rmldii AA
ZtllDlDlalry
In this from Veterirlaru School Animal
HulbllndilUY Unit were from 40 to
age was from 2~4 years old
blood )08tameters
Keywords