FIRST MILK

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REFERENCESChen HY, Mollstedt O, Tsai MH, Kreider RB.Potential Clinical Applications of Multi-Functional Milk Proteins and Peptides in Cancer Management. Curr Med Chem. 2014 Feb 5. [E-pub ahead of print]An MJ, Cheon JH, Kim SW, Park JJ, Moon CM, Han SY, Kim ES, Kim TI, Kim WH. Bovine colostrum inhibits nuclear factor kappaB-mediated proinflammatory cytokine expression in intestinal epithelial cells. Nutr Res. 2009 Apr;29(4):275-280. doi: 10.1016/j.nutres.2009.03.011.Masuda C, Wanibuchi H, Sekine K, et al. Chemopreventive effects of bovine lactoferrin on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced rat bladder carcinogenesis. Jpn J Cancer Res. 2000 Jun;91(6):582-588.Playford RJ, Macdonald CE, Johnson WS. Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders. Am J Clin Nutr, 72, No(1), 5-14, July 2000Hirano M, Iweakiri R, Fujimoto K, et al. Epidermal growth factor enhances repair of rat intestinal mucosa damaged after oral administration of methotrexate. J Gastroenterol 1995;30:169–176.[Medline]Sonis ST, Lindquist L, Van Vugt A, et al. Prevention of chemotherapy-induced ulcerative mucositis by transforming growth factor beta 3. Cancer Res 1994;54:1135–1138.[Abstract]Howarth GS, Francis GL, Cool JC, Ballard RW, Read LC. Milk growth factors enriched from cheese whey ameliorate intestinal damage by methotrexate when administered orally to rats. J Nutr 1996;126:2519–2530.[Medline]Gordler NM, McGurk M, Aqual S, Prince M. The effect of EGF mouthwash on cytotoxic-induced oral ulceration. Am J Clin Oncol 1995;18:403–406.[Medline]

FOOD FOR CHEMOTHERAPY Colostrum should be considered as a front line food

for chemotherapy patients as it “enhances the repair of rat intestinal mucosa damaged by methotrexate” and “ameliorates chemotherapy-induced mucositis.”

SINGLE VS MULTIPLE PEPTIDESUntil recently, most research has focused on the

use of a single peptide for the treatment of a particular condition. There is now increasing evidence, however, that administration of a combination of many peptides can result in additive or synergistic activity. “For example, the coadministration of GH and IGF-I stimulates anabolism and the coadministration of bovine lactoferrin and EGF stimulate the growth of the rat intestinal epithelial cell line…Orally administered colostrum-derived preparations therefore appear to be an attractive therapeutic option because they contain many different growth factors in a formulation that provides inherent protection against proteolytic digestion.”

Immune-Tree first milking colostrum supplies peptides

in first milk that never has its fat removed since the fatty acids protect the proteins as they go through the digestive process. Immune-Tree first milking colostrum is obtained from organically raised dairy cows fed pesticide-free grass.

Cutting down on cancer risk and treating it may involve the potential clinical applications of first milk proteins and peptides, say doctors writing in Current Medicinal Chemistry.

Colostrum, also known as first milk, contains therapeutic proteins and peptides that together

appear to reverse changes in the signaling of the tumor micro environment that enhance cancer spread.

One in three Americans is likely to experience cancer. Colostrum, a nutrient-rich fluid produced by female mammals immediately after giving birth, is loaded with immune, growth and tissue repair factors with dozens of biologically active peptides and proteins that affect genes and cell signaling.

“The progression of cancer involves multiple changes” in cellular signaling to promote cell proliferation, the research team said.

CANCER IMMUNOTHERAPIES Several colostrum-derived biologics, such

as HAMLET (human α-lactalbuminmade lethal to tumor cells) and the human recombinant form of lactoferrin, already have “demonstrated promising results in clinical trials.” Lactoferricin

peptide analogs are in early clinical development for cancer immunotherapies.

“In addition, milk proteins and peptides are well tolerated and many exhibit oral bioavailability, thus they may complement standard therapies to boost overall success in cancer treatments.”

CELL SIGNALING One of the smoking guns of cancer causation is nuclear

factor kappaB (NF-kappaB) signaling, which increases internal inflammation that changes the ability of cancer cells to adhere to tissues and spread. Human colon cancer HT-29 cells were stimulated with interleukin (IL)-1beta with or without bovine colostrum. By inhibiting NF-kappaB signaling in HT-29 cells, bovine colostrum reduced adhesion molecules and metastasis. “These data demonstrated that bovine colostrum might protect against [intestinal epithelial cells] inflammation by inhibiting the NF-kappaB pathway,” suggesting colostrum has a therapeutic potential for intestinal inflammation and cancer prevention. Additional studies confirm cancer stopping activity.

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