Cardiovascular Researchat Stanford | Retreat

October 27th, 20158:30 a.m. – 6 p.m.Li Ka Shing Center

Z Wine & Cheese poster reception 4:30p Y

Courtesy of Dom

inik Fleischmann

Every year, the Stanford Cardiovascular Institute

hosts the Annual Cardiovascular Research

Symposium to bring together its members and

highlight their research.

Established in 2004, the Institute is comprised of

scientists from numerous disciplines including

genetics, immunology, engineering, surgery and

medicine and some of the country's brightest

fellows and students.

Stanford has a tradition of being at the forefront

of cardiovascular innovation. Nearly 50 years ago,

Stanford ushered in the new era of cardiovascular

medicine in the United States by performing

the country’s first adult heart transplant. Today,

new opportunities have emerged to improve

diagnostics and therapy design for cardiovascular

diseases tailored to each patient and family.

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Meeting ScheduleWelcome Remarks (Joseph C. Wu, MD, PhD)

Garret FitzGerald, MDProgress with Prostanoids and their Inhibitors

Todd Brinton, MDThe Role of an Innovation Process for Development of CV Medical Devices

Paul Heidenreich, MDUnderstanding and Improving Implantable Defibrillator (ICD) Therapy

Coffee and Tea Break

Matthew Porteus, MDUsing the CRISPR/Cas9 System to Edit Primary Hematopoietic Cells

Marlene Rabinovitch, MDTargeting Points of Intersection of Genetics, Metabolism and Inflammation inPulmonary Hypertension

Dean Lloyd B. Minor, MDPrecision Medicine

Buffet Lunch

Clyde W. Yancy, MDAddressing Racial Disparities in Heart Failure: From the Bench to the Community

Kelly LaMarco, PhDTranslational Medicine: Minding the Gaps

Elena Matsa, PhDA Platform for Precision Medicine to Predict Drug Toxicity

Andrew ChangDach1 is a Mechanoregulated Transcription Factor

James Priest, MDMaternal Mid-pregnancy Glucose Levels & Risk of Congenital Heart Disease in Offspring

Coffee and Tea Break

Thomas Quertermous, MDMapping the Disease Pathways in Genome Wide Coronary Disease Associations

Matt Mell, MDBarriers to Regionalization for Complex Vascular Care

Alison L. Marsden, PhDComputational Surgical Planning in Pediatric and Congenital Heart Disease

Brian Kobilka, MDG Protein Coupled Receptors: Challenges in Drug Discovery

Live Music and Research Poster Reception

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Research prizes: Basic and clinical research awards (students and fellows)

1st: $1,000 | 2nd: $750 | 3rd: $500

Basic Research Judges: Vincio A. de Jesus Perez, MD; Phillip C. Yang, MD; and Sean Wu, MD, PhD

Clinical Research Judges: Ngan Huang, PhD; Joshua Knowles, MD, PhD; and Themistocles "Tim" Assimes, MD, PhD

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SPE

AKER

SELECTED WORK

Characterization of the molecular mech-anisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human in-duced pluripotent stem cell model system. Ebert AD, Kodo K, Liang P, Wu H, Huber BC, Riegler J, Churko J, Lee J, de Almeida P, Lan F, Diecke S, Burridge PW, Gold JD, Mochly-Rosen D, Wu JC. Sci Transl Med. 2014 Sep 24.

Epigenetic regulation of phosphodiester-ases 2A and 3A underlies compromised β-Adrenergic signaling in an iPSC model of dilated cardiomyopathy. Wu H, Lee J, Vincent LG, Wang Q, Gu M, Lan F, Churko JM, Sallam KI, Matsa E, Sharma A, Gold JD, Engler AJ, Xiang YK, Bers DM, Wu JC. Cell Stem Cell. 2015 Jul 2.

Chemically defined generation of human cardiomyocytes. Burridge PW, Matsa E, Shukla P, Lin ZC, Churko JM, Ebert AD, Lan F, Diecke S, Huber B, Mordwinkin NM, Plews JR, Abilez OJ, Cui B, Gold JD, Wu JC. Nat Methods. 2014 Aug.

CLINICAL FOCUS

Adult Congenital Heart Disease Cardiovascular Imaging

EDUCATION & TRAINING

MD Yale University

PhD UCLA

MEDICINE RESIDENCY UCLA Medical Center

CARDIOLOGY FELLOWSHIP UCLA Medical Center

BOARD CERTIFICATION Cardiovascular Disease, ABIM

My laboratory works on the biology of three types of stem cells (adult, embryonic and induced pluripotent stem cells (iPSC)). We use a combination of genetic approaches, tissue engineering, physiological testing, and imaging technologies, to understand their fundamental biology. For adult stem cells, we are involved in industry and NIH sponsored clinical trials. For embryonic stem cells (ESC), we are studying their safety. For iPSC, we are working on cardiovascular disease modeling, personalized drug screening, cell banking, and cell-based therapy. Equally exciting are efforts to develop vectors for cardiovascular gene therapy.

Joseph C. Wu, MD, PhDProfessor of Medicine (Cardiovascular Medicine)Professor of RadiologyDirector, Stanford Cardiovascular Institute

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SELECTED WORK

Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock. Liang X, Bushman FD, FitzGerald GA. Proc Natl Acad Sci USA. 2015 Aug 18.

Bioactive Products formed in Humans from Marine Lipids. Skarke C., Almuddin N., Lawson J.A., Ferguson J., Reilly M. and FitzGerald GA. J. Lipid Res. 2015 July.

EDUCATION & TRAINING

MD University College, Dublin

MSc School of Hygiene University of London

— KEYNOTE SPEAKER —

"Progress with Prostanoids and their Inhibitors"

Our laboratory has two areas of interest—prostanoid biology and the role of peripheral molecular clocks in cardiovascular biology, metabolism and aging. Perhaps the distinguishing feature of our groups is that we pursue interdisciplinary translational science with a focus on therapeutics. Thus, we work in different model systems—mammalian cells, worms, fish and mice—but also in humans. Ideally we develop quantitative approaches that can be projected from our experiments in the model systems to guide elucidation of drug action in humans.

Garret FitzGerald, MDProfessor of Medicine and PharmacologyChair Department of PharmacologyPerelman School of Medicine University of Pennsylvaniagarret@upenn.edu

SPEAKER

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SELECTED WORK

Teaching biomedical technology innova-tion as a discipline. Yock PG, Brinton TJ, Zenios SA. Sci Transl Med. 2011 Jul 20.

Cost-effectiveness landscape analysis of treatments addressing xerostomia in patients receiving head and neck radiation therapy. Sasportas LS, Hosford DN, Sodini MA, Waters DJ, Zambricki EA, Barral JK, Graves EE, Brinton TJ, Yock PG, Le QT, Sir-jani D. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 July.

EDUCATION & TRAINING

MD Chicago Medical School

RESIDENCY Stanford University

FELLOWSHIP Stanford University

"The Role of an Innovation Process for Development of CV Medical Devices"

My academic research focuses on the process of innovation for development of novel medical technologies. I specifically focus on the integration of research and development for new technologies with the clinical strategy and pre-clinical evaluation.

Todd Brinton, MDClinical Associate Professor, Medicine (Cardiovascular Medicine) tbrinton@stanford.edu

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SPEAKER

SELECTED WORK

Heart Failure Prevention and Team-based Interventions. Heidenreich P. Heart Fail Clin. 2015 July.

Feasibility of extended ambulatory elec-trocardiogram monitoring to identify silent atrial fibrillation in high-risk patients: the Screening Study for Undiagnosed Atrial Fibrillation (STUDY-AF). Turakhia MP, Ullal AJ, Hoang DD, Than CT, Miller JD, Friday KJ, Perez MV, Freeman JV, Wang PJ, Heidenre-ich PA. Clin Cardiol. 2015.

EDUCATION & TRAINING

MD University of Chicago

MS Health Services Research, Stanford University

INTERNAL MEDICINE RESIDENCY UCSF

CARDIOVASCULAR IMAGING FELLOWSHIP UCSF

CLINICAL CARDIOLOGY FELLOWSHIP UCSF

"Understanding and Improving Implantable Defibrillator (ICD) Therapy"

My current research interests include: 1) the cost-effectiveness of new cardiovascular technologies (for example, tests to screen asymptomatic patients for left ventricular systolic dysfunction); 2) interventions to improve the quality of care of patients with heart disease (for example, clinical reminders and home monitoring); 3) outcomes research using existing clinical and administrative datasets; and 4) use of echocardiography to predict prognosis.

Paul A. Heidenreich, MDProfessor of Medicine (Cardiovascular Medicine)Professor (by courtesy) of Health Research and Policyheiden@stanford.edu

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SELECTED WORK

Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells. Hendel A, Bak RO, Clark JT, Kennedy AB, Ryan DE, Roy S, Steinfeld I, Lunstad BD, Kaiser RJ, Wilkens AB, Bacchetta R, Tsalenko A, Dellinger D, Bruhn L, Porteus MH. Nat Biotechnol. 2015 Jun 29.

Genome Editing of the Blood: Opportunities and Challenges. Porteus MH. Curr Stem Cell Rep. 2015.

Quantifying genome-editing outcomes at endogenous loci with SMRT sequencing. Hendel A, Kildebeck EJ, Fine EJ, Clark JT, Punjya N, Sebastiano V, Bao G, Porteus MH. Cell Rep. 2014 Apr 10.

EDUCATION & TRAINING

MD Stanford University

RESIDENCY & FELLOWSHIP Children's Hospital Boston

“Using the CRISPR/Cas9 System to Edit Primary Hematopoietic Cells”

My lab was the first to demonstrate that gene correction could be achieved in human cells at frequencies that were high enough to potentially cure patients. My research program focuses on developing genome editing by homologous re-combination as curative therapy for children with genetic diseases. We are also interested in the clonal dynamics of heterogeneous populations and the use of genome editing to better understand diseases that affect children including infant leukemia’s and genetic diseases that affect the muscle.

Matthew Porteus, MDAssociate Professor of Pediatrics (Cancer Biology) mporteus@stanford.edu

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SELECTED WORK

Low-Dose FK506 (Tacrolimus) in End-Stage Pulmonary Arterial Hypertension.Spiekerkoetter E, Sung YK, Sudheendra D, Bill M, Aldred MA, van de Veerdonk MC, Vonk Noordegraaf A, Long-Boyle J, Dash R, Yang PC, Lawrie A, Swift AJ, Rabinovitch M, Zamanian RT. Am J Respir Crit Care Med. 2015 Jul 15.

BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension. Diebold I, Hennigs JK, Miyagawa K, Li CG, Nickel NP, Kaschwich M, Cao A, Wang L, Reddy S, Chen PI, Nakahira K, Alcazar MA, Hopper RK, Ji L, Feldman BJ, Rabinovitch M. Cell Metab. 2015 Apr 7.

EDUCATION & TRAINING

MD McGill University

PEDIATRICS RESIDENCY & INTERNSHIP University of Colorado

PEDIATRIC CARDIOLOGY FELLOWSHIP Baylor College of Medicine

PEDIATRIC CARDIOLOGY FELLOWSHIP Harvard Medical School

PEDIATRIC CARDIOLOGY RESEARCH FELLOWSHIP Harvard Medical School

"Targeting Points of Intersection of Genetics, Metabolism and Inflammation in Pulmonary Hypertension"

We investigate mechanisms leading to pulmonary arterial hypertension (PAH) with the view that we might better treat this devastating condition that has no cure except for lung transplantation. We discovered relationships between degradation of elastin by an endogenous elastase, loss of pre-capillary vessels, and prolifera-tion of vascular cells and showed that suppression of elastase activity could re-verse experimentally-induced PAH; we are now embarking on a translational proj-ect to bring elastase inhibitors into the clinic. In addition, we investigate the use of induced pluripotent stem cells to understand the genetic and epigentic factors that cause PAH.

Marlene Rabinovitch, MDDwight and Vera Dunlevie Professor of Pediatric CardiologyProfessor (by courtesy) of Developmental Biologymarlener@stanford.edu

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EDUCATION & TRAINING

MD Brown University

INTERNSHIP Duke University

RESIDENCIES Duke University, University of Chicago

FELLOWSHIP Ear Foundation and Otology Group of Nashville

"Precision Medicine"

Lloyd B. Minor, MD, is a scientist, surgeon, and academic leader. He is the Carl and Elizabeth Naumann Dean of the Stanford University School of Medicine, a po-sition he has held since December 2012. As dean, Dr. Minor plays an integral role in setting strategy for the clinical enterprise of Stanford Medicine, an academic medical center that includes the Stanford University School of Medicine, Stan-ford Health Care, and Stanford Children’s Health and Lucile Packard Children’s Hospital Stanford. He also oversees the quality of Stanford Medicine’s physician practices and growing clinical networks.

With Dr. Minor’s leadership, Stanford Medicine has established a strategic vision to lead the biomedical revolution in Precision Health. The next generation of health care, Precision Health is focused on keeping people healthy and providing care that is tailored to individual variations. It’s predictive, proactive, preemp-tive, personalized, and patient-centered. An advocate for innovation, Dr. Minor has provided significant support for fundamental science and for clinical and translational research at Stanford. Through bold initiatives in medical education and increased support for PhD students, Dr. Minor is committed to inspiring and training future leaders.

Among other accomplishments Dr. Minor has led the development and imple-mentation of an innovative model for cancer research and patient care delivery at Stanford Medicine and has launched an initiative in biomedical data science to harness the power of big data and create a learning health care system. Com-mitted to diversity, he has increased student financial aid and expanded faculty leadership opportunities.

Dean Lloyd B. Minor, MDThe Carl and Elizabeth Naumann Professorship for the Dean of the School of Medicine; Professor of Otolaryngology—Head & Neck Surgery and, by courtesy, of Neurobiology and BioengineeringDean_of_Medicine@stanford.edu

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SELECTED WORK

Social Determinants of Risk and Outcomes for Cardiovascular Disease: A Scientif-ic Statement From the American Heart Association. Havranek EP, Mujahid MS, Barr DA, Blair IV, Cohen MS, Cruz-Flores S, Davey-Smith G, Dennison-Himmelfarb CR, Lauer MS, Lockwood DW, Rosal M, Yancy CW. Circulation. 2015 Aug 3.

Strategies for early detection of cardiotox-icities from anticancer therapy in adults: evolving imaging techniques and emerging serum biomarkers. Akhter N, Murtagh G, Yancy C. Future Oncol. 2015 July.

EDUCATION & TRAINING

MD Tulane University

RESIDENCY Parkland Memorial Hospital, Internal Medicine

FELLOWSHIP University of Texas South-western Medical School, Dallas, Cardiology

CLINICAL INTERESTS

• Cardiomyopathy

• Heart Disease Prevention

• Heart Failure

• Hypertension

• Preventive Cardiology

• Valvular Heart Disease

— KEYNOTE SPEAKER —

"Addressing Racial Disparities in Heart Failure: From the Bench to the Community"

My research interests are in heart failure, heart transplantation, quality of care and health care disparities. At present I serve on the editorial boards of Circulation, Circulation Heart Failure and the American Heart Journal and am Associate Editor for the American Journal of Cardiology and Senior Section Editor (Heart Failure) for the Journal of the American College of Cardiology.

Clyde W. Yancy, MDVice Dean for Diversity and InclusionChief, Division of Medicine-CardiologyProfessor Medicine-Cardiology and Medical Social SciencesNorthwestern Feinberg School of Medicinecyancy@nmff.org

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EDUCATION & TRAINING

PhD University of Pittsburgh School of Medicine

FELLOWSHIP Carnegie Institution of Washington

"Translational Medicine: Minding the Gaps"

After receiving her MS and PhD in Biochemistry, Dr. LaMarco performed her post-doctoral research on mammalian transcriptional regulation at the Carnegie In-stitution of Washington. She then served as an Associate Editor for the journal Science, where she performed manuscript selection, writing, and editing. Dr. La-Marco next worked as a Staff Scientist and Project Leader of the Infectious Diseas-es Drug Discovery program at Tularik Inc., a then–privately-held biotechnology company. After leaving Tularik, she obtained funding for, led the development of, and served as Editorial Director of the Science of Aging Knowledge Environment (SAGE KE), AAAS's Web-based journal for researchers in the field of aging. At the same time she served as an editor for the policy Web site SAGE Crossroads, which was co-developed by the Alliance for Aging Research and AAAS. She was also the Director of West Coast Alliances for the New York Academy of Sciences and, in her spare time, worked as a scientific writer, editor, and consultant in academics and in the private sector. Dr. LaMarco helped to co-found Science Translational Medi-cine and has served as a Senior Editor since its launch in 2009.

Kelly LaMarco, PhDSenior Editor, Science Translational Medicine (San Francisco Office)klamarco@aaas.org

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"Transcriptomic Analysis of Inter- and Intra-patient Variation in Human iPSCs: Platform for Precision Medicine to Predict Drug Toxicity"

Elena Matsa, PhDInstructor, Cardiovascular Instituteematsa@stanford.edu(Joseph C. Wu, MD, PhD lab)

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"Dach1 is a Mechanoregulated Transcription Factor that Stimu-lates Coronary Artery Growth and Remodeling"

"Maternal Mid-pregnancy Glucose Levels and Risk of Congeni-tal Heart Disease in Offspring"

Andrew ChangPhD Student in Developmental Biology andrewhc@stanford.edu(Kristy Red-Horse, PhD lab)

James R. Priest, MDFellow in Pediatric Cardiology, Lucile Packard Children's Hospitaljpriest@stanford.edu

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SELECTED WORK

Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap. Nurnberg ST, Cheng K, Raiesdana A, Kundu R, Miller CL, Kim JB, Arora K, Carcamo-Oribe I, Xiong Y, Tellakula N, Nanda V, Murthy N, Boisvert WA, Hedin U, Perisic L, Aldi S, Maegdefessel L, Pjanic M, Owens GK, Tallquist MD, Quertermous T. PLoS Genet. 2015 May 28.

EDUCATION & TRAINING

MD University of Chicago

MEDICINE RESIDENCY & INTERNSHIP University of Chicago

CARDIOLOGY FELLOWSHIP Massachusetts General Hospital

RESEARCH FELLOWSHIP Harvard Medical School

"Mapping the Disease Pathways in Genome Wide Coronary Disease Associations"

My laboratory is interested in the molecular mechanisms that mediate vascular disease pathophysiology and the risk for these diseases. The approach is primar-ily genetic, using human cohorts and large scale genome wide studies to identify genes that associate with disease and risk, and molecular genetic studies to define the mechanisms of these associations. At the human level, we collaborate with a number of centers around the world through the CARDIoGRAM+C4D consortium to further identify coronary heart disease loci, and our group serves as the organiz-ing center searching for loci that associate with gold standard measures of insulin sensitivity, the GENESIS study. For loci identified through these studies, we work to identify mechanisms by which causal variation is responsible for altered gene structure or function, and employ cellular and genetic mouse models to identify how encoded factors participate in the disease process.

Thomas Quertermous, MDWilliam G. Irwin Professor in Cardiovascular MedicineProfessor of Medicine, Cardiovascular Medicinetomq1@stanford.edu S

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SELECTED WORK

Postoperative Surveillance and Long-term Outcomes After Endovascular Aneurysm Repair Among Medicare Beneficiaries. Garg T, Baker LC, Mell MW. JAMA Surg. 2015 Jul 8.

Adherence to postoperative surveillance guidelines after endovascular aortic aneu-rysm repair among Medicare beneficiaries. Garg, T., Baker, L. C., Mell, M. W. Journal of Vascular Surgery. 2015.

EDUCATION & TRAINING

MD Harvard University

RESIDENCY Stanford Univeristy

FELLOWSHIP University of Wisconsin

"Barriers to Regionalization for Complex Vascular Care"

My work focuses on comparative effectiveness of health care delivery for complex surgical diseases, including optimizing outcomes and cost effectiveness. My clin-ical interests include all aspects of vascular surgery, with a special emphasis on surgery for complex aortic disease, including endovascular repair of abdominal aortic aneurysm.

Matthew Mell, MDAssociate Professor of Surgery (Vascular Surgery) Stanford University Medical Centermwmell@stanford.edu

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SELECTED WORK

Computational modeling and engineering in pediatric and congenital heart disease. Marsden AL, Feinstein JA. Curr Opin Pediatr. 2015 Oct;27(5).

Computational simulation of the adap-tive capacity of vein grafts in response to increased pressure. Ramachandra AB, Sankaran S, Humphrey JD, Marsden AL. J Biomech Eng. 2015 Mar 1.

Simulation based planning of surgical interventions in pediatric cardiology. Mars-den AL. Phys Fluids (1994). 2013 Oct;25(10).

EDUCATION & TRAINING

BSE Princeton University,

Mechanical Engineering

MSE Stanford Univeristy

PhD Stanford Univeristy

POSTDOCTORAL FELLOWSHIP Stanford University, Pediatric Cardiology

“Computational Surgical Planning in Pediatric and Congenital Heart Disease”

The Cardiovascular Biomechanics Computation Lab at Stanford develops novel computational methods for the study of cardiovascular disease progression, surgi-cal methods, and medical devices. We develop novel algorithms for patient specific models of blood flow, including multi-scale models of the circulatory physiology, vascular growth and remodeling, design optimization and uncertainty quantifica-tion. We apply these methods to a range of clinical applications spanning pediatric and adult cardiology. We have particular interest in congenital heart disease, and have developed novel surgical methods to treat children born with single ventricle heart disease that have been translated to clinical use. We collaborate closely with clinicians in pediatric cardiology at Lucile Packard Children’s Hospital and around the world. Projects in the lab aim to improve surgical designs and increased our understanding of disease progression and patient risk stratification for congenital heart defects, coronary artery disease, Kawasaki disease, and ventricular assist devices.

Alison L. Marsden, PhDAssociate Professor of Pediatrics and Bioengineering, and (by courtesy) of Mechanical EngineeringInstitute for Computational and Mathematical Engineeringamarsden@stanford.edu

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SELECTED WORK

Structural insights into µ-opioid receptor activation. Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S6, Gmeiner P5, Husbands SM, Traynor JR, Weis WI, Steyaert J, Dror R, Kobilka BK. Nature. 2015 Aug 5.

EDUCATION & TRAINING

MD Yale Univeristy

INTERNAL MEDICINE RESIDENCY Washington University

RESEARCH FELLOWSHIP Duke University

"G Protein Coupled Receptors: Challenges in Drug Discovery"

The goal of research in my lab is to characterize the structure and mechanism of activation of G protein coupled receptors (GPCRs). GPCRs represent the larg-est group of cellular receptors for hormones and neurotransmitters in the human body. They play central roles in the network of cellular communication that or-chestrates the physiological processes essential for life. Disruption of one or more components of this complex communication network can lead to a broad spec-trum of diseases ranging from cardiovascular and metabolic disorders, to neu-ropsychiatric and neurodegenerative disorders. GPCRs are therefore important targets for drug discovery. We apply a spectrum of biochemical and biophysical tools to investigate the molecular mechanism of GPCR signaling in cells, and the structural basis for regulation of GPCR function by drugs. We are also working to discover new approaches for the more efficient and economical development of safer and more effective therapeutics targeting these receptors.

Brian Kobilka, MDHelene Irwin Fagan Chair in CardiologyProfessor of Molecular and Cellular PhysiologyProfessor of Medicine (Cardiovascular Medicine)Professor (by courtesy) of Chemical and Systems Biologykobilka@stanford.edu

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SELECTED WORK

Early surgical intervention or watchful waiting for the management of asymp-tomatic mitral regurgitation: a systematic review and meta-analysis. Goldstone AB, Patrick WL, Cohen JE, Aribeana CN, Popat R, Woo YJ. Ann Cardiothorac Surg. 2015 May;4(3).

Non-resectional leaflet remodeling mitral valve repair preserves leaflet mobility: A quantitative echocardiographic analysis of mitral valve configuration. Shudo Y, Cohen JE, MacArthur JW, Goldstone AB, Hiraoka A, Howard J, Fairman AS, Patel J, Edwards BB, Atluri P, Woo YJ. Int J Cardiol. 2015 May.

Aligned-Braided Nanofibrillar Scaffold with Endothelial Cells Enhances Arteriogenesis.Nakayama KH, Hong G, Lee JC, Patel J, Edwards B, Zaitseva TS, Paukshto MV, Dai H, Cooke JP, Woo YJ, Huang NF. ACS Nano. 2015.

EDUCATION & TRAINING

MD University of Pennsylvania

SURGERY RESIDENCY & INTERNSHIP University of Pennsylvania

RESEARCH FELLOWSHIP University of Pennsylvania

CARDIOTHORACIC SURGERY FELLOWSHIP University of Pennsylvania

BOARD CERTIFICATION Surgery, ABS Thoracic Surgery, ABTS

My research focus is the development of new genetic and molecular strategies for treating myocardial ischemia and heart failure. We are investigating new paths to myocardial repair using stem cells and tissue engineering. We are also exploring the newest techniques and devices for heart care: innovative approaches to mitral and aortic valve repair; smaller, more efficient mechanical heart pumps; and oper-ations performed without stopping the heart.

Y. Joseph Woo, MDNorman E. Shumway ProfessorChair, Cardiothoracic SurgeryProfessor (by courtesy) of Bioengineering and of Surgeryjoswoo@stanford.eduM

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SELECTED WORK

Epicardial FSTL1 reconstitution regenerates the adult mammalian heart Wei K, Serpooshan V, Hurtado C, Diez-Cuñado M, Zhao M, Maruyama S, Zhu W, Fajardo G, Noseda M, Nakamura K, Tian X, Liu Q, Wang A, Matsuura Y, Bushway P, Cai W, Savchenko A, Mahmoudi M, Schneider MD, van den Hoff MJ, Butte MJ, Yang PC, Walsh K, Zhou B, Bernstein D, Mercola M, Ruiz-Lozano P. Nature. 2015 Sep 24.

Long-term challenges in congenital heart disease. Bernstein D. Curr Opin Pediatr. 2015 Oct.

Patient-Specific Pluripotent Stem Cells in Doxorubicin Cardiotoxicity: A New Window Into Personalized Medicine. Bernstein D, Burridge P. Prog Pediatr Cardiol. 2014 Dec.

EDUCATION & TRAINING

MD New York University

PEDIATRICS RESIDENCY Montefiore Medical Center

MEDICAL EDUCATION FELLOWSHIP Albert Einstein College of Medicine

PEDIATRIC CARDIOLOGY FELLOWSHIP UCSF

BOARD CERTIFICATION Pediatrics, ABPPediatric Cardiology, ABP

Our lab has several major focuses, including: (1) The role of the G protein coupled receptors in regulating cardiac function, and specifically mitochondrial structure and function; (2) The differences between right and left ventricular responses to stress and in their modes of failure, including gene expression and miR regulation; (3) Using iPSC-derived myocytes to understand heart failure and congenital heart disease; and (4) We are developing tools for evaluation of cardiovascular physiol-ogy in transgenic and knockout mice and in isolated cardiomyocytes.

Daniel Bernstein, MDAlfred Woodley Salter and Mabel G. Salter Endowed Professor of Pediatrics (Cardiology) danb@stanford.edu

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SELECTED WORK

Meta-analysis of intracranial hemorrhage in acute coronary syndromes: incidence, predictors, and clinical outcomes. Mahaffey KW, Hager R, Wojdyla D, White HD, Arm-strong PW, Alexander JH, Tricoci P, Lopes RD, Ohman EM, Roe MT, Harrington RA, Wallentin L. J Am Heart Assoc. 2015 Jun 18.

The future of cardiovascular clinical research in North America and beyond-addressing challenges and leveraging opportunities through unique academic and grassroots collaborations. Roe MT, Mahaffey KW, Ezekowitz JA, Alexander JH, Goodman SG, Hernandez A, Temple T, Berdan L, Califf RM, Harrington RA, Peterson ED, Armstrong PW. Am Heart J. 2015 Jun.

Glycoprotein IIb/IIIa Receptor Inhibitors in Combination With Vorapaxar, a Platelet Thrombin Receptor Antagonist, Among Patients With Non-ST-Segment Elevation Acute Coronary Syndromes (from the TRAC-ER Trial). Cornel JH, Tricoci P, Lokhnygina Y, Moliterno DJ, Wallentin L, Armstrong PW, Aylward PE, Clare RM, Chen E, Leonardi S, Van de Werf F, White HD, Held C, Strony J, Mahaffey KW, Harrington RA. Am J Cardiol. 2015 May.

EDUCATION & TRAINING

BS Stanford University

MD University of Washington

INTERNSHIP/RESIDENCY/CHIEF RESIDENCY University of Arizona

RESEARCH FELLOWSHIP University of Pennsylvania

FELLOWSHIP Duke University

My primary research interest is the design and conduct of multi-center clinical trials and analyses of important clinical cardiac issues using large patient databases. My research focuses on novel anticoagulation agents for the treatment of acute coronary syndromes and atrial fibrillation, the study of agents targeted to protect the myocar-dium during reperfusion therapy for acute myocardial infarction, and the evaluation of cardiovascular safety of diabetic therapies.

Kenneth Mahaffey, MDProfessor of Medicine (Cardiovascular Medicine)kenneth.mahaffey@stanford.edu

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SELECTED WORK

Naive T cell maintenance and function in human aging. Goronzy JJ, Fang F, Cavana-gh MM, Qi Q, Weyand CM. J Immunol. 2015 May.

Macrophages in vascular inflamma-tion--From atherosclerosis to vasculitis. Shirai T, Hilhorst M, Harrison DG, Goronzy JJ, Weyand CM. Autoimmunity. 2015 May.

Serpin treatment suppresses inflamma-tory vascular lesions in temporal artery implants (TAI) from patients with giant cell arteritis. Chen H, Zheng D, Ambadapadi S, Davids J, Ryden S, Samy H, Bartee M, Sobel E, Dai E, Liu L, Macaulay C, Yachnis A, Weyand C, Thoburn R, Lucas A. PLoS One. 2015 Feb.

EDUCATION & TRAINING

MD University of Aachen

DR. MED University of Bonn

PhD University of Heidelberg

MEDICINE RESIDENCY Hannover Medical School

RHEUMATOLOGY FELLOWSHIPStanford University

BOARD CERTIFICATIONInternal Medicine, GermanyRheumatology, Germany

My research program is focused on defining and characterizing pathogenic im-mune responses in humans with emphasis on two disease models; inflammatory blood vessel disease and rheumatoid arthritis. In large vessel vasculitis, we have defined disease-relevant T cells, discerned mechanisms of T cell-antigen recogni-tion, connected different T cell lineages to early and late disease and discovered micro-environmental signals that shape pathogenic immunity in the walls of hu-man arteries. We were the first to describe the role of arterial wall dendritic cells in sensing danger-associated molecular patterns and initiating vasculitis and have implicated NOTCH-NOTCH ligand interactions in directing the tissue tropism of large vessel vasculitis. We build patient-relevant experimental models by engraft-ing human blood vessels, human atherosclerotic plaque and human immune cells into mice. Work in rheumatoid arthritis has identified premature immune aging as a typifying defect in this autoimmune syndrome. We are examining the contribu-tion of DNA instability, telomeric damage and metabolic abnormalities in acceler-ated immune cell aging and inflammatory disease.

Cornelia Weyand, MD, PhDProfessor of Medicine (Immunology and Rheumatology) Chief, Division of Immunology and Rheumatology cweyand@stanford.edu

BASIC SCIENCE

Injectable Hydrogels with Double Network Formation To Promote Angiogenesis. Lei Cai,

Ruby Dewi, Sarah Heilshorn Department of Materials Science & Engineering, Stanford

Multiclonal Large-Scale RNASeq Analyses To Define iPSC Variability, Gene Regulatory Net-works And eQTLS Relating To A Complex Human Disease Model. Carcamo-Orive, Ivan1, Cundiff,

Paige2, Chang, Rui3, Knowles, Joshua W.1, Hoffman, Gabriel E.3, Whalen, Sean4, Beckman, Noam D.3,

Patel, Achchhe2, Papatsenko, Dimitri2, Abbasi, Fahim1, Reaven, Gerald1, Shahbazi, Mohammad1,

Sevilla, Ana2, Hendry, Carolin2, Schadt, Eric3, Lemischka, Ihor2, Pandey, Gaurav3, D’Souza, Suni-

ta2, Quertermous, Thomas1 1Cardiovascular Institute, Stanford, 2Department of Developmental and

Regenerative Biology, Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, 3Department of Genetics and Genomic Sciences, Institute of Genomics and Multiscale Biology, Mount

Sinai School of Medicine, New York, NY, 4Gladstone Institutes, San Francisco

The Molecular Mechanisms of Metabolism Modulators Reduce Cellular Lipid Accumula-tion in Cardiomyocytes of Human Neutral Lipid Storage Disease. Chun-Yuan Chan, Kuppu-

samy Rajarajan, Sean M. Wu Stanford Cardiovascular Institute, Stanford

Dach1 is a Mechanoregulated Transcription Factor that Stimulates Coronary Artery Growth and Remodeling. Andrew H Chang1,3, Aruna Poduri3, Vinay Surya2, Brian Raftrey3,

Heidi Chen1,3, Alex Dunn2, Gerald Fuller2, Kristy Red-Horse3 Department of Developmental Biol-

ogy1, Department of Chemical Engineering2, Department of Biology3, Stanford

Telomere and Mitochondrial Dysfunction in Duchenne Muscular Dystrophy. Alex C.Y.

Chang1,3, Sang-Ging Ong2,3, Edward LaGory4, Vittavat Termglinchan2,3, Ioannis Karakikes2,3, Ama-

to J Giaccia4, Joseph Wu2,3 and Helen M Blau1,3. 1Baxter Laboratory for Stem Cell Biology, Depart-

ment of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, 2Division of Cardiology, Department of Medicine, 3Stanford Cardiovascular Institute, and 4Division

of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford

ISL1 Gene Targets Identified Using Human Induced Pluripotent Stem Cell Derived Cardio-myocytes. Jared M Churko1,2,3, Jaecheol Lee1,2,3, Vittavat Termglinchan1,2,3, Nathan Salamonis4,

Joseph Wu1,2,3 1Institute of Stem Cell Biology and Regenerative Medicine; 2Stanford Cardiovas-

cular Institute; 3Departments of Medicine and Radiology; 4Division of Biomedical Informatics,

Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

Physiologic Mitochondrial Fragmentation is a Cardiac Adaptation to Increased Energy Demand. Michael Coronado1,2, Giovanni Fajardo1,2, Kim Nguyen1, Mingming Zhao1,2, Kristina

Bezold Kooiker1,2, Gwanghyun Jung1,2, Dong-Qing Hu1,2, Sushma Reddy1,2, Erik Sandoval1,2,

Aleksandr Stotland3, Roberta A. Gottlieb3, Daniel Bernstein1,2. The Department of Pediatrics

Abstracts

(Cardiology)1, Cardiovascular Research Institute2, Stanford and the Division of Molecular Cardi-

ology, Heart Institute, Cedars-Sinai Medical Center, Los Angeles3

Targeted Delivery of RNA using Knottin-Protein Conjugates for the Treatment of Athero-sclerosis and Abdominal Aortic Aneurysms. Sandra M DePorter1, Sungwon Lim1, Camila R

Kofman2, Toshinobu Saito3, Michael V McConnell3, Jennifer R Cochran1,2 1Department of Bioen-

gineering, Stanford , 2Department of Chemical Engineering, Stanford, 3Division of Cardiovascu-

lar Medicine, Stanford

The Cellular Origin and Transcriptional Regulation of F8 expression. Thanh Theresa Dinh,

Junliang Pan, Mike Lee, Anusha Rajaraman and Eugene Butcher, Stanford

Purifying Atrial and Ventricular hiPSC-derived Cardiomyocytes Using CRISPR/Cas9. E.

Dzilic1, A. Kumar1, K. Plonowska1, SM. Wu1 1Institute for Stem Cell Biology and Regenerative

Medicine, Stanford

TCF21 Regulates Coronary Artery Disease Causing Aryl-hydrocarbon Receptor Gene Ex-pression and its Downstream Pathway Activation by Environmental Ligands. Juyong Brian

Kim, Milos Pjanic, Olga Sazanova, Trieu Nguyen, Tina Wang, Clint Miller, and Thomas Querter-

mous, Stanford

CDKN2B Regulates Efferocytosis and Phenotypic Switching in Atherosclerosis. Daniel DiRen-

zo, Yoko Kojima, Vivek Nanda, and Nicholas J. Leeper Department of Surgery, Stanford

Structural and Functional Studies on β2AR Phosphorylation by GRK5. Yang Du*1,2, Kon-

stantin Komolov*3, Nyu M Duc4, KaYoung Chung4, Jeffrey L Benovic3, Brian Kobilka1,2 1Stanford

University, Department of Molecular and Cellular Physiology, Stanford; 2Stanford Cardiovascular

Institute, Stanford; 3Thomas Jefferson University, Department of Biochemistry and Molecular Bi-

ology, Philadelphia, PA; 4Sungkyunkwan University, School of Pharmacy, Suwon, South Korea

Injectable Hydrogels for Tandem Cell/Gene Transplantation. Abbygail A. Foster1,2, Lei Cai 1,2, Ngan F. Huang 2,3,4, Sarah C. Heilshorn 1,2; 1Department of Materials Science and Engineering,

Stanford; 2Stanford Cardiovascular Institute; 3Veterans Affairs Palo Alto Health Care System,

Palo Alto; 4Division of Cardiovascular Medicine, Stanford

Combinatorial Extracellular Matrices Promote Survival and Phenotype of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells in Hypoxia. Luqia Hou, John

Coller, Vanita Natu, Ngan F. Huang, Stanford

Correction of Human Phospholamban R14del Mutation Associated with Cardiomyopathy Us-ing Targeted Nucleases and Combination Yherapy. Karakikes I1,2,3, Stillitano F3, Nonnenmacher

M3, Termglinchan V2, Wu JC1,2, Hulot JS3, Hajjar RJ3 (+18 additional authors); 1Department of Med-

icine, Division of Cardiovascular Medicine, Stanford; 2Stanford Cardiovascular Institute; 3Cardiovas-

cular Research Center, Icahn School of Medicine at Mount Sinai, New York, New York, NY

Controllable Nanotopographical Cues from Electrospun PCL/PEO Fibrous Scaffolds Fa-cilitate Endothelial Cell Differentiation of Human Pluripotent Cells. Joseph J. Kim, PhD,

Luqia Hou, Nicholas Mezak, John Coller, Vanita Natu, Ngan F. Huang, Stanford

Abnormal Activation of TGFβ Signaling as a Pathogenesis of Left Ventricular Non-com-paction Cardiomyopathy. Kazuki Kodo1,2, Sang-Ging Ong1,2, Fereshteh Jahanbani3, Vittavat

Termglinchan1,2,4, Hirono Keiichi6, Kolsoum InanlooRahatloo1,2, Antje D. Ebert1,2,4, Praveen Shuk-

la1,2, Oscar J. Abilez1,2, Jared M. Churko1,2,4, Ioannis Karakikes1,2,4, Gwanghyun Jung2,5, Fukiko

Ichida6, Sean M. Wu1,2, Michael P. Snyder3, *Daniel Bernstein2,5, *Joseph C. Wu1,2,4 1Department

of Medicine, Division of Cardiology, 2Stanford Cardiovascular Institute, 3Department of Genetics, 4Institute of Stem Cell Biology and Regenerative Medicine, 5Department of Pediatrics, Stanford, 6Department of Pediatrics, University of Toyama

Pediatric Hypertrophic Cardiomyopathy (HCM) Mutations in Human ß-myosin Heavy Chain (b-MHC) Show Mutation-specific Changes in the Tate of ATP Hydrolysis and In Vitro Motility. Kooiker, K*1, Adhikari, A*2, Sutton, S2, Ruppel, K2, Spudich, J2 and Bernstein, D1 *Authors contrib-

uted equally to the research 1Department of Pediatrics 2Department of Biochemistry, Stanford

PPARγ Controls DNA Damage Response by Modulating UBR5 Interaction with the MRE11-RAD50-NBS1 Complex. CG Li1, CS Mahon2, E Verschueren2, V Kantamani1, K Cimprich1

and M Rabinovitch1 1Stanford University, 2University of California, San Francisco

Identification of Cardiovascular Lineage Descendants at Single-Cell Resolution. Guang

Li*, Adele Xu*, Karolina plonowska, Rajarajan Kuppusamy, Anthony Sturzu, Sean M. Wu

Stanford Cardiovascular Institute

Antagonism of Rosuvastatin-induced Elevation of Circulating PCSK9 in Hamsters by Liver-specific Knockdown of HNF1 Transcription Factors. Bin Dong, Amar Bahadur Singh,

Vikram Ravindra Shende and Jingwen Liu Department of Veterans Affairs, Palo Alto Health

Care System, Palo Alto

Morphine-induced Cardioprotection: The Past, Present and Future. Yao Lu, Eric R. Gross*

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, School of

Medicine, Stanford

The Unraveling Stent. Toby Lundh Visiting Professor in the VIBE Lab at Stanford Medicine, Vascu-

lar Surgery Professor in Mathematics at Chalmers University of Technology, Gothenburg, Sweden

Transcriptomic Analysis of Inter- and Intra-patient Variation in Human iPSCs: Platform for Precision Medicine to Predict Drug Toxicity. Elena Matsa1,2,3, Paul W. Burridge1,2,3,

Kun-Hsing Yu4,5, John H. Ahrens1, Haodi Wu1,2,3 , Praveen Shukla1,2,3, Jared M. Churko1,2,3, Jo-

seph D. Gold1, Michael P. Snyder4, Joseph C. Wu1,2,3 1Stanford Cardiovascular Institute, 2Depart-

ments of Medicine and Radiology, 3Institute of Stem Cell Biology and Regenerative Medicine, 4Department of Genetics, 5Biomedical Informatics Training Program, Stanford

Investigating the Role of Wall Shear Stress Gradients on Human Lymphatic Endothelial Cells. Eleftheria Michalaki1, Vinay Surya1, Yorgos Katsikis2, Gerald Fuller1, and Alex Dunn1,3,

1Department of Chemical Engineering, Stanford, 2Department of Mechanical Engineering, Stan-

ford, 3Stanford Cardiovascular Institute

Integrative Fine-mapping of Regulatory Variants and Mechanisms at Coronary Artery Disease Loci. Clint L. Miller1*, Milos Pjanic1*, Tina Wang1, Trieu Nguyen1, Ariella Cohain2, Jon-

athan Lee1, Themistocles L. Assimes1, Eric E. Schadt2, Thomas Quertermous1, +7 additional

authors, 1Department of Medicine, Division of Cardiovascular Medicine, Stanford, 2Department

of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn

School of Medicine at Mount Sinai, NY

Contact-Mediated Interaction Between Pulmonary Artery Endothelial and Smooth Muscle Cells Promotes a BMPR2-Notch1 Signal Causing Hyperpolarization of Endothelial Mitochondria and a Stalk Cell-Like Phenotype. Kazuya Miyagawa, Caiyun G. Li, Jan K. Hen-

nigs, Shalina Taylor, Jan-Renier Moonen, Silin Sa, Lingli Wang, Aiqin Cao, Marlene Rabino-

vitch Department of Pediatrics, Vera Moulton Wall Center for Pulmonary Vascular Disease and

Cardiovascular Institute, Stanford

Nanoscale Extracellular Matrix Alters Endothelial Function Under Disturbed Flow. Karina H. Nakayama1,2,3, Vinay Narayanan1,4, Monica Gole3, Travis Walker5, Weiguang Yang6,

Edwina S. Lai4 Maggie Ostrowski4, Gerald G. Fuller4, Alex R. Dunn1,4, Ngan F. Huang1,2,3 1Stan-

ford Cardiovascular Institute, Stanford, CA 2Department of Cardiothoracic Surgery, Stanford

School of Medicine, Stanford, CA 3Veterans Affairs Pfine-lo Alto Health Care System, Palo Alto, 4Department of Chemical Engineering, Stanford University School of Engineering, Stanford, CA 5Department of Chemical Engineering, Oregon State University, Corvallis, OR 6Department of

Pediatrics, Stanford

CDKN2B Regulates TGFβ1 Mediated Smooth Muscle Cell Recruitment to Ischemic Blood Vessels. Vivek Nanda1, Kelly P. Downing 1, Yoko Kojima 1, Daniel M DiRenzo 1, Joshua M. Spin 2, Andrew J Connolly 3, Sonny Dandona 4, Ljubica Perisic 5, Ulf Hedin 5, Lars Maegdefessel 6,

Jessie Dalman 1, Liang Guo 7, XiaoQing Zhao 7, Frank D. Kolodgie 7, Renu Virmani 7, Harry R.

Davis Jr. 7, Nicholas J. Leeper 1,2, Departments of Surgery 1, Medicine 2 and Pathology 3 Stan-

ford; Department of Medicine 4, McGill University, Montreal, Canada; Departments of Molecular

Medicine and Surgery 5 and Medicine 6, Karolinska Institute, Stockholm, Sweden; and CVPath

Institute 7, Gaithersburg, MD

Regulation of GSK3β by TRPV1 in Cardiomyocytes. Honit Piplani, Carl M Hurt, Yao Lu, Eric

R Gross Department of Anesthesiology, Perioperative and Pain Medicine, Stanford

Multifunctional Assessment of the Cardiac Activity of Single iPSC-derived Cardiomy-ocytes for Disease Modeling. Alexandre J. S. Ribeiro1,2, Olivier Schwab1, Mo A. Mandegar3,

Ekaterina Frolov3, Nathaniel Huebsch3, Bruce R. Conklin3, Beth L. Pruitt1,2,4 1. Department of

Mechanical Engineering and 2Stanford Cardiovascular Institute, 4Gladstone Institute of Cardio-

vascular Disease and University of California San Francisco, and 4Department of Molecular and

Cellular Physiology, Stanford

Assimilation and Propagation of Clinical Data Uncertainty in Cardiovascular Modeling. Dan-

iele E. Schiavazzi1, Alison L. Marsden1 1Department of Pediatric, Bioengineering and ICME, Stanford

Deciphering Molecular Mechanisms Underlying Familial Hypertrophic Cardiomyopa-thy with Isogenic Induced Pluripotent Stem Cells. Timon Seeger1, Ioannis Karakikes1,

Vittavat Termglinchan1, Caressa Chen1, Mohammed Ameen1, Joseph C. Wu1. 1Stanford

Cardiovascular Institute

Biomaterial Approaches for Cardiovascular Tissue Engineering. Vahid Serpooshan1,

Daniel A. Hu1, Tony Sinclair1, Soah Lee2, Xinming Tong3, Pu Chen4, Utkan Demirci4, Fan Yang3,

Sean M. Wu 1-4 1Stanford University Cardiovascular Institute; 2Dept. of Materials Sci. and Eng.; 3Dept. of Orthopedic Surgery; 4 Dept. of Radiology; 2 Division of Cardiovascular Medicine, Dept.

of Medicine; 3Institute for Stem Cell Biology and Regen. Medicine, 4 Child Health Research Insti-

tute, Stanford

Single Cell Cloning of Human Pluripotent Stem Cells: Clonal Expansion of Single Geneti-cally Modified hPSCs through Co-culture with their Un-modified Counterparts. Moham-

mad Shahbazi1, Paige Cundiff2, Fahim Abbasi1,Sunita D’Souza2, Ihor Lemischka2, Joshua W.

Knowles1, Thomas Quertermous1. 1Stanford School of Medicine and Stanford Cardiovascular

Institute, Stanford, 2Icahn School of Medicine at Mount Sinai, Department of Developmental

and Regenerative Biology, New York, NY

High-Throughput Screening of Tyrosine Kinase Inhibitors in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Reveals a Class-Specific Cardiotoxicity Pattern. Arun

Sharma, BS1, 2, 3*, Paul W. Burridge, PhD1, 2, 4*, Alexandra Holmström, PhD1, 2, 3, Elena Matsa,

PhD1, 2, 3, Jared M. Churko, PhD1, 2, 3, Wesley McKeithan, BS5, Yuan Zhang1, 2, 3, Anusha Kumar,

BS1, 2, 3, Mark Mercola, PhD5, Sean M. Wu, MD PhD1, 2, 3, Joseph C. Wu, MD PhD1, 2, 3 1Stanford Car-

diovascular Institute, 2Institute for Stem Cell Biology and Regenerative Medicine; 3Department

of Medicine, Division of Cardiology, Stanford; 4Department of Pharmacology and Center for

Pharmacogenomics, Northwestern University Feinberg School of Medicine, Chicago, IL; 5Muscle

Development and Regeneration Program, Sanford-Burnham Medical Research Institute, La

Jolla, CA

Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes as an In Vitro Model for Doxorubicin-Induced Cardiotoxicity. Alice Shieh1, 2, 3, Ryoko Hamaguchi1, 2, 3, 4 , Arun Sharma1, 2,

3, 4, Paul W. Burridge6, Joseph C. Wu1, 2, 3, 4, 5, Sean M. Wu1, 2, 3 1Department of Medicine, Division of

Cardiology; 2Institute for Stem Cell Biology and Regenerative Medicine; 3Stanford Cardiovascu-

lar Institute; 4Department of Biology, 5Department of Radiology, Stanford School of Medicine; 6Department of Pharmacology, Northwestern Feinberg School of Medicine, Chicago, IL

Delineating Hypokalemia-induced Ventricular Arrythmogenicity Using Human iPSC-de-rived Cardiomyocytes. Praveen Shukla1-3, Priyanka Garg1-3, Evangeline Tzatzalos1-3, Elena

Matsa1-3, Wenyi Chen1-3, Arun Sharma1-3, Oscar J. Abilez1-3, Joseph D. Gold1,5, & Joseph C. Wu1-3

1Stanford Cardiovascular Institute, 2Institute for Stem Cell Biology and Regenerative Medicine, 3Department of Medicine, Division of Cardiology, 4Department of Chemistry, 5Department of

Cardiothoracic Surgery, Stanford University School of Medicine, Stanford

Vitamin D Restores Functional Abilities of Fetal Endothelial Progenitor Cells From Pregnancies Complicated by Preeclampsia. Frauke von Versen-Höynck, MD, MSc1, 3, Lars

Brodowski MD1;Jennifer Burlakov MD1; Carl A. Hubel, PhD2, 1Division of Reproductive Endocri-

nology and Infertility, Stanford, 2Department of Obstetrics and Gynecology, Hannover Medical

School, Germany 3Magee Womens Research Institute and Foundation, Pittsburgh, PA

Mitochondrial Transient Receptor Potential Vanilloid 1 (TRPV1) Mediates Endothelial Dysfunction in Diabetes Nana-Maria Wagner MD, PhD, Carl M. Hurt MD, PhD, Stacy McAllister

PhD, Eric R. Gross MD, PhD Department of Anesthesiology, Perioperative and Pain Medicine,

Stanford

Cell-cell adhesions and tension as regulators of myofibrils and sarcomeres. Robin E. Wil-

son, Alexandre J.S. Ribeiro, Beth L. Pruitt, Department of Mechanical Engineering, Stanford

Cord Blood Endothelial Progenitor Cells are Altered in Preeclampsia. Diane Gumina, BA1,

Claudine P Black, BS2, Vivek Balasubramaniam, MD2, Virginia Winn, MD, PhD1,3 and Christo-

pher D Baker, MD2. 1Dept of Obstetrics and Gynecology, 2Dept of Pediatrics, University of Colora-

do School of Medicine, Aurora, CO, and 3 Dept. of Obstetrics and Gynecology, CHRI, CVI, Stanford

Epigenetic Activation of Phosphodiesterase Subtypes Lead to Compromised Beta-adren-ergic Signaling in Induced Pluripotent Stem Cell-derived Cardiomyocytes From Dilated Cardiomyopathy Patients. Haodi Wu, Jaecheol Lee, Mingxia Gu, Feng Lan, Jared Churko,

Elena Matsa, Karim Sallam, Joseph D. Gold, Joseph C. Wu. Department of Medicine, Division of

Cardiology, Cardiovascular Institute, Stanford

Resistin Promotes Inflammation by Upregulating Expression of Inflammatory Markers in Macrophages. Mary C. Zuniga2,3, Gayatri Raghuraman2,3 Elizabeth Hitchner2,3 and Wei Zhou1,2,3 1Stanford Cardiovascular Institute 2VA Palo Alto Healthcare Systems, Vascular Surgery, 3Vascular

Surgery, Stanford

CLINICAL RESEARCH

Addressing the Controversy of Estimating Pulmonary Arterial Pressure by Echocardiogra-phy. Myriam Amsallem1*, Joshua M. Sternbach2, Sasikanth Adigopula1, Yukari Kobayashi1, Thu

A. Vu1, Roham Zamanian2, David Liang1, Gundeep Dhillon1, Ingela Schnittger1, Michael V. Mc-

Connells1, François Haddad1, 1Department of Cardiovascular Medicine, Stanford, 2Department of

Pulmonary and Critical Care, Stanford

Importance of Beta-blocker Subtype for the Risk of Perioperative Adverse Events in Low and High Risk {atients Undergoing Non-cardiac Surgery. Mads Emil Jørgensen1,2, Gunnar

Hilmar Gislason1,3,4,5, Christian Torp-Pedersen6, Mark Hlatky2, Charlotte Andersson1. 1The

Cardiovascular Research Center, Department of Cardiology, Gentofte Hospital, University of

Copenhagen, Denmark, 2Department of Health Research and Policy, Stanford, 3Faculty of Health

and Medical Sciences, University of Copenhagen, Denmark, 4National Institute of Public Health,

University of Southern Denmark, Copenhagen, Denmark, 5The Danish Heart Foundation, Copen-

hagen, Denmark, 6Department of Health Science and Technology, Aalborg University, Denmark

Secular Trends In Complications of Atrial Fibrillation 2004-2012: The Treat-AF Study. Daniel W. Kaiser, MD1,2 Alexander C. Perino2, Jun Fan MS1, Susan Schmitt PhD1, Mintu P. Turakh-

ia1,2, 1Veterans Affairs Palo Alto Health Care System, Palo Alto, CA; 2Stanford University School of

Medicine

The Relationship between Coronary Microvascular Dysfunction and Preclinical Left Ven-tricular Diastolic Dysfunction: Invasive Physiologic and Echocardiographic Study. Yuhei

Kobayashi, Yukari Kobayashi, Francois Haddad, Vedant Pargaonkar, David P. Lee, William F.

Fearon, Alan C . Yeung, and Jennifer A. Tremmel, Stanford

Myocardial Deformation Imaging and Obstruction in Hypertrophic Cardiomyopathy, Insights From Cross-sectional and Post-myectomy Analysis. Yukari Kobayashi, Gherardo

Finocchiaro, Genevieve Giraldeau, David Boulate, Yuhei Kobayashi, Richard Ha, David Lee,

Matthew Wheeler, David Liang, Ingela Schnittger, Francois Haddad, Euan Ashley, Stanford

Ventricular Remodeling of the Athlete’s Heart: A Systematic Review and Meta-analysis. Zoë Kooreman1, Guillaume Fadel1, David Hsu1, Myriam Amsallem MD1, Euan Ashley MD1, Keith

George PhD2, Victor Utomi PhD2, Victor Froelicher MD1, Francois Haddad MD1. 1Department of

Cardiovascular Medicine, Stanford 2;Cardiorespiratory Research Group, Research Institute for

Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK

Heart Failure Patients Hospitalized with Bacterial Infections: A Nationwide Analysis of Concomitant Clostridium Difficile Infection Rates and In-Hospital Mortality. Petra Mamic,

MD1, Paul A Heidenreich, MD, MS1,2,3, Haley Hedlin, PhD1, Lakshika Tennakoon, MD MS4, Kristan

L Staudenmayer, MD MS4, 1Department of Medicine, Stanford; 2Stanford Cardiovascular Insti-

tute; 3VA Palo Alto Health Care System, Palo Alto; 4Department of Surgery, Stanford

Maternal Mid-pregnancy Glucose Levels and Risk of Congenital Heart Disease in Offspring. James R Priest MD1,2,3, Wei Yang MS 3, Gerald Reaven MD3, Joshua W. Knowles MD PhD3, Gary M.

Shaw Dr PH 3. 1Division of Pediatric Cardiology and Stanford Cardiovascular Institute, Stanford; 2Staford Cardiovascular Institute; 3Department of Pediatrics, Stanford; 4Division of Cardiovascular

Medicine and Stanford Cardiovascular Institute, Stanford

Towards the Promise of Personalized Medicine: Using Machine Learning to Identify Patients with Undiagnosed Atherosclerotic Disease and Predict Major Adverse Cardiovas-cular Events. Elsie (Gyang) Ross, MD, MSc1, Nicholas Leeper, MD1, Nigam Shah, PhD2 1Division of

Vascular Surgery, Stanford; 2Department of Biomedical Informatics, Stanford

Engineered Anisotropic Substrates Promote the Function of Cardiomyocytes Derived from Human Pluripotent Stem Cells. Maureen Wanjare, Joseph Jung-Woong Kim, Ngan F. Huang,

Stanford

Mechanisms For Discrepancies Between Phase and Activation Timing Maps in Identify-ing Sites where Local Ablation Terminates Human Persistent Atrial Fibrillation. 1Junaid

Zaman, 2Gautam Lalani, 1,2Tina Baykaner, 1Mark Swerdlow,1Shirley Park, 2David Krummen, 1Paul Wang, 1Sanjiv Narayan 1Stanford Cardiovascular Institute, 2VA Medical Center, University of

California-San Diego, CA

Safety and Effectiveness of Catheter Ablation of Atrial Fibrillation in Patients with Chronic Kidney Disease. Aditya J. Ullal BA1,2, Daniel W. Kaiser MD2, Jun Fan MS1, Susan Schmitt

PhD1, Claire T. Than MPH1, Wolfgang C. Winkelmayer MD MPH ScD3, Paul A. Heidenreich MD

MS1,2, Jonathan P. Piccini MD MHSc4, Marco V. Perez MD2, Paul J. Wang MD2, Mintu P. Turakhia

MD MAS1,2 1Veterans Affairs Palo Alto Health Care System, Palo Alto; 2Stanford University School

of Medicine, Stanford; 3Baylor College of Medicine, Houston, TX; 4Duke University Medical Center,

Durham, NC

POPULATION RESEARCH

Cardioversion and Risk of Adverse Events with Dabigatran Versus Warfarin: A Nationwide Cohort Study. Jannik Langtved Pallisgaard1,2, MD; Tommi Bo Lindhardt1,2, MD, PhD; Morten

Lock Hansen1,3, MD, PhD; Anne-Marie Schjerning Olsen1, MD, PhD; Jonas Bjerring Olesen1,MD,

PhD; Laila Staerk, MD(1,2); Christian Torp-Pedersen4, MD, DMSc; Gunnar Gislason1,2,5,6, MD,

PhD. 1Department of Cardiology, Copenhagen University Hospital Gentofte, Hellerup, Denmark; 2Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; 3The Heart Centre,

Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark; 4Institute of Health,

Science and Technology, Aalborg University, Aalborg, Denmark; 5The National Institute of Public

Health, University of Southern Denmark, Copenhagen, Denmark; 6The Danish Heart Foundation,

Copenhagen, Denmark

Notes

Notes

http://cvi.stanford.edu