carlos cruchaga webinar july 2014

2
Alzforum Webinar July 8 th . 2014

Upload: alzheimer-research-forum

Post on 07-Jul-2015

2.049 views

Category:

Health & Medicine


1 download

DESCRIPTION

Webinar presentation made by Dr. Carlos Cruchaga, July 8, 2014 - http://www.alzforum.org/webinars/mutations-impair-trem2-maturation-processing-and-microglial-phagocytosis

TRANSCRIPT

Page 1: Carlos Cruchaga Webinar July 2014

Alzforum WebinarJuly 8th. 2014

Page 2: Carlos Cruchaga Webinar July 2014

The variants with the highest functional impact, do not need to show the most significant association with disease risk

CSF TREM2 levels better biomarker than plasma levels

Is there any other variant (cis/trans) that affect CSF TREM2 levels?

Does the different TREM2 alternative transcript play a role in TREM2 function/pathogenesis?