cartilage and bone
TRANSCRIPT
Cartilage and Bone
VIBS 443/602
OBJECTIVES
GENERAL ORGANIZATION
MECHANISM OF GROWTH
CHARACTERISTICS OF CELLS
CELLS OF CT
FIBROBLASTS
MESENCHYMAL
CELLS and RBC
ADIPOSE CELLS
MACROPHAGE
PLASMA CELLS
MAST CELLS and WBC
CHONDROBLASTS
CHONDROCYTES
OSTEOBLASTS
OSTEOCYTES
OSTEOCLASTS
TYPES OF CARTILAGE
FIBROCARTILAGE
HYALINE CARTILAGE ELASTIC CARTILAGE
primary spongiosa of the Fetal finger
220
Fetal elbow 194
Fetal elbow 194
Tibia, fetal 421
Trachea, monkey 133
EM 11: cartilage
1. Chondrocyte
2. Fibroblast
3. Appositional
growth region
4. Type I collagen
5. Type II collagen
Appositional growth of
cartilage
EM 13: cartilage interstitial growth of
chondrocytes
1. 2 daughter chondrocytes resulting
from interstitial growth
2. Rough endoplasmic reticulum
interstitial growth of
cartilage
HYALINE
CARTILAGE
EPIPHYSEAL PLATE,
RESPONSIBLE FOR
LONGITUDINAL GROWTH
OF LONG BONES
cartilage growth in endochondral bone
formation of the Fetal finger
220
OSTEOCLAST
OSTEOBLAST
OSTEOCLAST
OSTEOBLAST
Elastic cartilage in pina of ear
#19762
Elastic cartilage
Connective
tissue
epithelium Connective
tissue
epithelium
Elastic cartilage
FIBROCARTILAGE
INTERMEDIATE BETWEEN
DENSE REGULAR
CONNECTIVE TISSUE
AND HYALINE
CARTILAGE
NO PERICHONDRIUM
Fibrocartilage of Fetal elbow
194
Fibrocartilage
Fibrocartilage
Fibrocartilage of Fetal elbow
194
Fibrocartilage
Fibrocartilage of Fetal elbow 194
Fibrocartilage
Fetal finger – fibroblasts in tendon
220
Fibrocartilage Tendon
endochondral
bone formation
CELLS OF BONE
OSTEOBLASTS - SECRETE OSTEOID - BONE
– EXPAND BONE BY APPOSITIONAL GROWTH
OSTEOCYTE =
OSTEOBLAST
TRAPPED IN
MATRIX OF
BONE
EM 12: osteoblast adjacent to
osteoid; bone; RER and Golgi
1. Rough endoplasmic reticulum
2. Golgi
3. Osteoid
4. Nucleus of osteoblast
APPOSITIONAL GROWTH
CELLS OF BONE
FUNCTIONS OF BONE
CALCIUM REGULATION Parathroid hormone (BONE
RESORPTION)
Calcitonin (PREVENTS RESORPTION)
These HORMONES are INVOLVED IN TIGHT REGULATION as
1/4 OF FREE CA++ IN BLOOD IS EXCHANGED EACH MINUTE.
HEMOPOIESIS
COMPACT BONE
HAVERSIAN
SYSTEMS - LAMELLAE OF BONE
AROUND HAVERSIAN
CANAL LINKED BY
VOLKMANN’S CANAL
COMPACT BONE REMODELING
Over time
COMPACT BONE REMODELING
Slide 121: compact bone
(unstained ground bone)
1. Blood vessel
2. Haversian canal
3. Interstitial system
4. Lacuna
Bone (unstained) 425
Bone (unstained) 425
Bone, rabbit femur 121
Bone, rabbit femur 121
Bone, rabbit femur 121
Tibia, fetal 421
Osteoblasts in the Fetal jaw 195
Osteoclasts, osteoblasts, and
osteocytes in Fetal jaw 195
osteocytes
osteoclasts
osteoblasts
How many Osteoclasts of Fetal
finger can you spot?
Osteoclasts
220
ENDOCHONDRAL (SPONGY/
CANCELLOUS) BONE FORMATION
CARTILAGE MODEL
CENTERS OF OSSIFICATION
PRIMARY CENTER OF
OSSIFICATION
• DIAPHYSIS
SECOND CENTER OF
OSSIFICATION
• CENTER OF EACH EPIPHYSIS
cartilage growth in endochondral bone formation of the Fetal finger
220
Articular surfaces of hyaline cartilage of the
Fetal elbow 194
HISTOGENESIS OF BONE INTRAMEMBRANOUS
OSSIFICATION
FLAT BONES
OF SKULL
SKELETAL CONNECTIVE
TISSUE
Polychromatic
normoblast
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