cefblue az
TRANSCRIPT
CEFBLUE-AZ
Cefblue-AZCefixime 200mg + Azithromycin 250mg Tablet
Cefblue-AZ 500Cefixime 200mg + Azithromycin 500mg Tablet
Cefixime• Oral third generation broad spectrum cephalosporin
antibiotic active against Gram negative, limited Gram positive and anaerobic bacteria..
• Used to treat infections of the: Ear (otitis media) Nose, Sinuses (sinusitis), Throat (tonsillitis, pharyngitis), Chest and lungs (bronchitis, pneumonia) and Urinary system and Uncomplicated gonorrhea.
• Bactericidal action• Absorption: Only 40-50% is absorbed from the GI tract
(oral); rate may be decreased if taken with food. Greater absorption from oral suspensions than tablet.
• Adverse Drug Reactions include diarrhea, dyspepsia, nausea, vomiting. Hypersensitivity reactions like skin rashes, utricaria.
Mechanism of ActionCefixime
PBPs in Bacterial Cell Wall
Inhibits bacterial Cell Wall synthesis
Death of Bacteria
Affinity to bind
Cefixime Indications(1) Uncomplicated urinary tract infections caused by
Escherichia coli and Proteus mirabilis, (2) Otitis media caused by Haemophilus influenzae (beta-
lactamase positive and negative strains), Moraxella catarrhalis (most of which are beta-lactamase positive), and S. pyogenes,
(3) Pharyngitis and tonsillitis caused by S. pyogenes, (4) Acute bronchitis and acute exacerbations of chronic
bronchitis caused by Streptococcus pneumoniae and Haemophilus influenzae (beta-lactamase positive and negative strains), and
(5) Uncomplicated gonorrhea (cervical/urethral) caused by Neisseria gonorrhoeae (penicillinase- and non-penicillinase-producing strains).
Azithromycin• It is an azalide, a subclass of macrolide antibiotics• Azithromycin retains the activity of erythromycin
against gram-positive organisms but offers increased gram-negative coverage over erythromycin and clarithromycin.
• Azithromycin is used to treat or prevent certain bacterial infections, most often those causing middle ear infections, strep throat, pneumonia, typhoid, and sinusitis.
• It is also effective against certain sexually transmitted infections
• Absorption is approximately 37% after a 500-mg oral dose
• Azithromycin exhibited a rapid bacteriostatic effect
Mechanism of ActionAzithromycin
50s Subunit of Bacterial Ribosomes
Inhibits translation of mRNA
Interfering with their protein synthesis
Affinity to bind
Prevents bacteria from growing
Azithromycin Indications(1) Acute Bacterial Sinusitis(2) Acute Otitis Media(3) Community-Acquired Pneumonia(4) Pharyngitis/Tonsillitis(5) Uncomplicated Skin & Skin Structure Infections(6) Chronic Obstructive Pulmonary Disease
Generic name Erythromycin Clarithromycin Azithromycin
FDA approval date April 09, 1959 October 31, 1991 November 1, 1991
Intravenous form Yes No Yes
Half-life 1-1.5 hours 3-7 hours 40-60 hours
Bioavailability 25% 55% 38%
Potential for interactions High High Low
FDA Pregnancy Category B C B
Macrolide Comparison
Cefixime + Azithromycin Combination
• Wide antibacterial spectrum against gram-positive and gram-negative bacterias with enhanced anti-staphylococcal activity and stability in the presence of several b-lactamases
• Excellent intracellular tissue penetration and a long elimination half life aids in the bacterial eradication.
• Synergy between two antibiotics against bacterial pathogens.
• Wide anti microbial spectrum covering respiratory and urinary tract pathogens.
• Minimum chances of resistance development• Alternative drug therapy for typhoid.
Ref.-1. Nihon Rinsho. 2009 Jan;67(1):129-35.2. Am Fam Physician. 2010 Apr 1;81(7):873-8.
Cefblue AZEach tablet of CEFBLUE AZ contains Cefixime Trihydrate IPEquivalent to anhydrous Cefixime……………………….200mgAzithromycin Dihydrate IP Equivalent to Azithromycin………………………………...250mg
Each tablet of CEFBLUE AZ 500 contains Cefixime Trihydrate IPEquivalent to anhydrous Cefixime……………………….200mgAzithromycin Dihydrate IP Equivalent to Azithromycin………………………………...500mgDosage: As directed by the physician.
Cefblue AZ
MRP- Rs. 192/- Only
MRP- Rs. 290/- Only
Market Analysis
Brand Name Company Pack MRP / Strip
Zifi-AZ (200+250) FDC 10’s 169.00
Clofee AZ (200+500) Nucleo Remedies 10’s 250.00
Cefdac AZ (200+250) Jaiwik Biotec 10’s 175.00
Zithrox-Plus (200+250) Macleods 10’s 178.00
AZIFINE-C (200+500) Glenmark 10’s 200.00
ZITHROX PLUS-KID tab (100+125)
Macleods 10’s 98.8
Marketing GuidelinesLaunching Month-• Do extensive RCPA and identify 20 doctors in each territory• Detail with Visual Aid (Cefixime). • Provide 5 strip samples to each doctor during the first visit.• Make a second and if possible 3rd visit and detail the product with
Literature.• Demand 10 prescriptions from each doctor for the month.
2nd Month onwards:• Identify most potential prescribers.• Sample 5 strips per Doctor for two visits• Make a third reminder visit.• Detail with Visual Aid for remaining doctors without any sampling.• Demand and monitor 10 prescriptions from each of the 5
identified most potential doctor for the month.