cell development ii cell signaling and disease models cell social media bka
TRANSCRIPT
Group Members
• Nishi Bryska, UNC Charlotte• Sharon Bullock, UNC Charlotte• Katie Crump, VCU-IRACDA• Teshell Greene, VCU-IRACDA• Derek Kendig, VCU-IRACDA• Michelle Pass, UNC CharlotteFacilitator: Suann Yang, Presbyterian College
Context of the Teachable Unit
• General biology major’s class (cell biology section)
• Target class size is 60 students, with 10 working groups of 6 students each
• Co-requisite coursework: general chemistry• A one semester course, 2 lectures at end of the
semester. • 5 hours class time total, 10 hours out of class
time.
Learning GoalsStudents should understand 1. How a signal is transduced, relayed, and
amplified to lead to a biological response.2. The regulation and termination of a biological
signal and response in normal and diseased states.
3. How cell signaling regulates homeostasis.
Tidbit ObjectivesStudents should be able to:
1. Describe how a message is communicated.2. Diagram a signaling pathway.3. Predict how disturbing the components of
the pathway will affect cell signaling response.
Prior Knowledge Gained• Cell signaling terms – Protein-protein interactions– Receptor– Ligand and how it interacts with receptors– Signal relay and response
• Cell membranes are selectively permeable• Extracellular signals elicit cellular responses• Basics of regulation
Group Work (4 mins)
Diagram a Signaling Model Using The Shapes Provided
-Take shapes out of the envelope
-Use shapes to model the pathway
Group Work (4 mins)
Diagram a Signaling Model Using The Shapes Provided
-Take shapes out of the envelope
-Use shapes to model the pathway
Hint:Orange = same type of molecule
Real World Scenario
For upcoming polls please enter the site http://www.pollev.com into your web browser or set
your phone up to text message the number ‘37607’ as the phone number.
Clinical Scenario
In diabetes the response of one important pathway is to transport glucose from the extracellular fluid (ECF)/blood into the cytosol of cells.
This pathway becomes disrupted as part of diabetes.
Type II DiabetesThe process of glucose accumulation in the
extracellular fluid or blood is due to insulin resistance (inactivation of receptor)
Glucose level