center for biological physics lori goldner, jenny ross adrian parsegian direct measurement of...
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Center for Biological PhysicsLori Goldner, Jenny Ross
Adrian Parsegian
Direct measurement of intermolecular forces
to build a physics of molecular organization
Watching single molecules move through channels
Theory of intermolecular forces organizing soft materials, colloids and large bio-molecules
exploded virus and intact virus
Bacteriophage T2 Kleinschmidt et al. (1962)
DNA spooled inside a virusA. Evilevitch, (2006).
Viral DNA is under pressure that can drive infection:
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are needed to see this picture.
Equation of State: Osmotic pressure vs. DNA density, function of salt, temperature, etc.
Building a physics of forces and energies for nanometer-to-micrometer - size particles
Unified equation of state for flexible polymers: Osmotic pressures of many sizes and concentrations fit with ONE parameter.
Joel Cohen (Univ Pacific), Rudi Podgornik (Slovenia)
To be part-time @UMass
25 µm
1 cm
_+
2 nm
70 µm
E(mV)
I(pA)
100 µm
10 ms
pA
Detection
10 ms
pA
Current through channel
0
Sergey Bezrukov, Philip Gurnev
Building an apparatus in Hasbrouck next month
Transport through single ionic channels Current detection of single-molecule transit
Theory of intermolecular forces
(electrostatics, electrodynamics, solvation, steric) example of single-walled carbon nanotubes
Rick Rajter, Rudi Podgornik, Roger French, Wai-Yim Ching, AP
Connection between dielectric spectra
and van der Waalstorques/forces.
Under study
DNA, Lipids (cell membranes), Proteins
Xiangyun Qiu, Rudi Podgornik, to be working @UMass
Jason DeRouchey, Don Rau, et al. at NIH (where I used to work)
Thanks