central council for research in unani medicine
TRANSCRIPT
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Dr Mohammed Khalid SiddiquiDirector
CENTRAL COUNCIL FOR RESEARCH IN UNANI MEDICINEMinistry of Health & Family Welfare, Govt. Of India Department of Ayurveda, Yoga & Naturopathy, Unani, Siddha &
Homoeopathy (AYUSH)
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Definition of Unani Medicine
Unani Tibb (Medicine) -Science of which we learn the various states of body, in health and when not in health, and the means by which health is likely to be lost and, when lost is likely to be restored
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Historical Perspective
� Origin - Greece
� Hippocrates - Father of Unani Medicine
� Eminent Iranian physicians like Tabari, Rhazes, Majoosi, Avicenna and Jurjani etc.
� Philosophy greatly influenced by thoughts of Iranian physicians - anatomy, physiology and pathology
� Medical school in Jundishapur in 3rd century AD.
� Jundishapur - a mile stone in medical teaching/training for many centuries.
� Scholars translated Greek medical text of Hippocrates and Galen & provided Philosophy of Unani medicine.
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� Egypt, Syria, Iraq and Spain – also contributed.
� Unani Medicine in India 13th Century.
� Mughal period - Hay Days.
� Many eminent Unani physicians form Iran and
Central Asia settled in India.
� India - the world leader in Unani Medicine
� Popular and practiced in Pakistan,
Bangladesh, Malaysia, Indonesia, China, Sri
Lanka, Kuwait, Dubai, Saudi Arabia & South
Africa etc., with different names .
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Salient Features
� Science of health & disease.
� Provides principles of healthy living.
� Based on Hippocratic theory of four humors
and temperaments.
� Specific methods of diagnosis
� Eco-friendly practices, therapies and
remedies.
� Natural raw materials mainly from plant origin
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� Individualized and holistic approach
� Do’s and don’ts related to food
� Equilibrium in humors - basis of treatment.
� Preventive, curative, meditation and
rehabilitation.
� Comprehensive approach of treatment in non-
communicable, metabolic, degenerative,
psychosomatic and lifestyle disorders.
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Infrastructure
30 National and State Medicinal Plants Boards
22 StatesState Boards/Councils of Homoeopathy
21 StatesState Boards/Councils of ASU
22 StatesState Directorates
3892Beds in Government Hospitals
958Dispensaries
177Hospitals
453Drug manufacturing units
70Admission capacity P.G. colleges
1435Admission capacity undergraduate colleges
45Colleges/teaching institutions (Undergraduate -37 & Postgraduate-08)
45,000Institutionally qualified practitioners
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Education & Practice
• Education is regulated by Central Council of
Indian Medicine a statuary body set-up by an Act
of Parliament known as IMCC Act of 1970.
• Affiliation to different Universities
• Graduate course of four and half years duration
is offered followed by one year internship training
- Bachelor of Unani Medicine and Surgery
(BUMS).
• Postgraduate courses in 6 subjects of three years
duration - M.D (Unani)
• National Institute of Unani Medicine
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Research & Teaching Institutions
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Good Manufacturing Practices (GMP)
• Good Manufacturing Practices (GMP) for preparing the drugs
• State Licensing Authorities
• Infrastructure of factories.
• Storage of raw material.
• Manufacturing area, machines & processing
• Record keeping
• In-house quality control & quality assurance
• Finished goods store
• Hygienic Working conditions
• PLIM/Drug Testing labs.
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Traditional Knowledge Digital
Library (TKDL)
• Documentation of traditional knowledge.
• 1,10,000 formulations from 14 Unani classical texts.
• Available in English, Spanish, French, German and Japanese languages in international patent compatible format.
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Quality Control of Drugs
• Section 33-C of the Drug & Cosmetics Act 1940 in 1982.
• Drug Technical Advisory Board under Drugs & Cosmetics Act 1940 for ASU drugs
• Drugs Consultative Committee
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Unani Pharmacopoeia Committee
• Unani Pharmacopoeia Committee
• CCRUM - secretariat for Unani Pharmacopoeia Committee.
• National Formulary of Unani Medicine (NFUM) Volume-I, II, III & IV, consisting of 441, 202, 103, 178 compound Unani Formulations in English and Urdu language .
• National Formulary Volume-VI
• Unani Pharmacopoeia of India (UPI) Part-1 (Vol. I II, III, IV & V).
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Fundamentals of Unani Medicine
� Unani Medicine - Concept of elementology i.e. groups of four elements, air, water, fire and earth.
� Hippocratic theory of four humours i.e. blood, phlegm, bile and black bile.
� Every physical existence is the combination of above four groups of elements.
� Human body is a microcosm developed with the combination of above groups of elements.
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Concept of Immunity & Principles of
Treatment
� Healthy state of individual - unique humoral
constitution.
� Medicatrix naturae.
� Strengthening medicatrix naturae
� Balancing of disturbed humoral composition by-
� Diversion of diseased matter
� Evacuation of diseased matter
� Normalizing the disturbed temperament
� Restoring the weakened faculties of systems,
organs, tissues and cells
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Modes of Treatment
��Regimental therapyRegimental therapy
��DietotherapyDietotherapy
�� Pharmacotherapy Pharmacotherapy
�� Surgery Surgery
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Regimental Therapies
� Cupping (Hajamat)
� Leaching (Taleeq)
� Venesection (Fasad)
� Dalak (Massage)
� Hammam (Turkish bath)
� Exercise (Riyazat)
� Diuresis (Idrar)
� Sweating (Tareeq)
� Cauterization (Kai)
� Counter irritation (Imala)
� Purging (Ishal)
� Vomiting (Qai)
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Dieto - Therapy
�� Dietary irregularities Dietary irregularities –– measure cause measure cause
�� Dietary regimen Dietary regimen
�� Principle of eating Principle of eating -- two parts for food, one each two parts for food, one each for water and air.for water and air.
�� Eat only when hungry.Eat only when hungry.
�� Dietary restrictions Dietary restrictions
�� Many diseases are treated only by regulating diet.Many diseases are treated only by regulating diet.
�� DietoDieto--TherapyTherapy
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Pharmacotherapy
�� Unique temperament of each drug.Unique temperament of each drug.
�� Herbal, mineral & animal origin drugsHerbal, mineral & animal origin drugs
�� Four potency levels of drugs. Four potency levels of drugs.
�� Single as well as compound formulation Single as well as compound formulation
�� Special drugs Special drugs -- indicated for particular indicated for particular humoralhumoral diseases. diseases.
�� Special compound preparation Special compound preparation -- KhamiraKhamira, , MajoonMajoon, , TiryaqTiryaq, , ItrifalItrifal, , JawarishJawarish, , SharbatSharbat, , KushtaKushta, , TilaTila, , ZemadZemad, Decoction, Infusion etc. , Decoction, Infusion etc.
�� Opposite temperamental drugs Opposite temperamental drugs -- used to counter the used to counter the humoralhumoralimbalance imbalance
44--5%5%Animal Animal
55--6%6%Mineral Mineral
90%90%Herbal Herbal
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Areas of Strength (Potentialities)
� Anti-ageing
� Immunomodulatory
� Hepato-protective
� Chronic inflammatory diseases.
� Autoimmune disorders
� Gastrointestinal disorders
� Hepato-billiary diseases
� Sexual disorders.
� Articular and bone diseases
� Psychosomatic disorders
� Neurological disorders
� Skin and blood related diseases.
� Cardio vascular diseases
� Life style and communicable diseases
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Research Programme
Clinical Research
Pharmacology and safety evaluation
Validation of Hippocratic fundamentals
Drug Standardization
Literary and Medico-historical Research
Ethno-botanical Survey, Collection, Experimental and Large scale Cultivation of Unani Medicinal Plants
IEC and HRD programmes
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Clinical Research Programme
• Validation - Theory of pathogenesis,
symptomatology, safety evaluation,
clinical methods of diagnosis and
treatment.
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Pharmacological/Safety Studies
• Reverse pharmacological studies for classical Unani products.
• Clinical trials of Unani drugs are carried out as per WHO guidelines on set protocols in collaboration with modern hospitals/institutions.
• Efficacy and safety evaluation - recorded by Joint Investigators from Modern and Unani discipline.
• Global standards - followed for drug development and standardisation of Unani drugs.
• Pharmacological studies on 120 drugs based on modern pharmacological method.
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Diseases on which extensive clinical studies
have been undertaken & leads achieved
• Vitiligo
• Eczema/Psoriasis
• Infective hepatitis
• Acid peptic disease
• Bronchial asthma
• Hypertension
• Malaria
• Filariasis
• Diabetes mellitus
• Rheumatoid arthritis
• Sinusitis
• Hperlipidemia
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Some of the Achievements in
Clinical Research
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Bars (Vitiligo)• Treated over 1,00,000 patients of Bars (vitiligo)
• Conducted extensive clinical studies on 30,000 cases
• 6 formulations with 60% to 89% efficacy
• Package - includes oral and a topical application
• No side effects recorded
• Incompatible diet - one of causative factor
• Duration of treatment
• Myths
• Herredo-familial studies - 20%-30% inheritance
• Gastro intestinal disorders, allergy, worm infestation and use of antibiotics aggravate the disease
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Response in VitiligoBefore treatment After treatment
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Iltehab-e-Tajaweef Anf (Sinusitis)
• Two oral and one drug for inhalation
• The poly herbal formulation - found
effective in 6-8 weeks in Radiologically
positive cases.
• No side effects
• No relapse.
• Radiological findings
• 78-80% efficacy.
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Waja-ul-Mafasil (Rheumatoid Arthritis )
• Multicentric clinical studies of poly herbal Unani formulations in collaboration with modern hospital was conducted on 400 cases
• Oral drug - administered along with local application on effected joints.
• Efficacy rate -70-80%
• No side effect
• No gastric irritation and hyperacidity.
• Mobility of the joints - significantly improved.
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Zeequn Nafas (Bronchial Asthma)
• Poly herbal Unani drug
• Multicentric trial
• 1200 cases
• 74% efficacy
• Periodicity of the attack - reduced
• Frequency reduced.
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Nar-e-Farsi/Dausadaf (Eczema/ Psoriasis)
• 04 formulations (local + oral) studied in
different types of Eczema and Psoriasis
• 68%-75% efficacy
• Recurrence 20%-25% cases
• Duration varied with the chronicity of the
disease
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Response After treatment Before treatment
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Gul-e-Babuna
(Matricaria chamomilla)
Asgandh
(Withania somnifera)
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Zanjabeel
(Zingiber officinale)
Chadela
(Parmilia perlata)
Some of the Medicinal Plants Used in
formulations
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Turbud sufaid
(Operculina tupethum)
Majeeth Irani
(Rubia cordifolia)
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Kaifal
(Myrica nagi)
Sad kufi
(Cyperus rotundus)
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Waj
(Acorus calamus)
Gul-e-Tesu
(Butea monosperma)
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Qaranfal
(Syzygium aromaticum)
Narkachoor
(Zingiber zerumbet)
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Khulanjan
(Alpinia galanga)
Suranjan Shirin
(Colchicum autumnale)
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Patents (29 drugs) Filed
Drug for (Gingivitis) UNIM- 2007 (Capsule Sirus)
Drug for (Rheumatoid arthritis)UNIM- 2006 (Capsule Shaqeeqa)
UNIM-2017 (Qurs-e-Tursh Mushtahi)UNIM- 2005 (Capsule Nazla)
UNIM- 2016 (Qurs- e- Surfa)UNIM- 2004 (Capsule Mubarak)
UNIM- 2015 (Qurs- e- Musaffi)UNIM- 2003 (Capsule Hudar)
UNIM- 2002 (Capsule Habis)
UNIM- 2001 (Capsule Deedan)
UNIM- 401& UNIM- 403 (Eczema)
UNIM- 304(Rheumatoid arthritis)
UNIM- 005(Leucoderma)
UNIM- 270(Filariasis)
UNIM- 105 (Hepatitis)
UNIM- 2014 (Qurs- e- Muqawwi)
UNIM- 2013 (Qurs- e- Mulayyan)
UNIM- 2012 (Qurs- e- Mafasil)
UNIM- 2011 (Qurs- e- Haiza)
UNIM- 2010 (Qurs- e- Bel)
UNIM- 2009 (Capsule Musaffi)
UNIM- 2008 (Capsule Tinkar)
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Collaborations with Scientific Organizations
• All India Institute of Medical Sciences, New Delhi
• Vallabh Bhai Patel Chest Institute, Delhi
• Lady Harding Medical College, New Delhi
• Aligarh Muslim University
• Jamia Hamdard, New Delhi
• Deccan Medical College, Hyderabad.
• CSIR
• ICMR
• KGMC Etc.
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Unani Medical Centre at
Dr. RML Hospital New Delhi• GOPD and Specialty Clinics
• Average attendance is 250 patients
• More than 4 lakhs patients registered and treated so far.
• Good percentage of referred cases - from Modern Medicine OPDs.
• Higher acceptability of the system and high public appreciation.
• Old age patients - much benefited.
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Mobile Clinical Research Programme
• Treatment facilities through Unani Medicine at the door steps of the population in the rural and far flung areas.
• Mobile units visits the adopted pockets twice weekly and provide treatment to the patients.
• 23,00,000 populations covered
• 220 villages covered.
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Drugs Standardization Research
• Evolving Pharmacopoeial standards
for single and compound Unani drugs
• Developing SOP for compound Unani
formulations.
• 250 single drugs
• 300 compound drugs
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Literary Research Programme
• Editing, collation, and translation of classical Persian and Arabic manuscripts and rare books of Unani Medicine
• Compilation of books and literature on Unani Medicine in different languages.
• Reprinting of out of print classical Unani books.
• Digitalization of classical Unani books.
• Persian, Arabic, Uzabaki, Thai, German languages – Literature publication
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Survey and Cultivation of Medicinal
Plants Programme• Survey of different forest regions
• Collection of information on tribal medicinal folk claims
• Experimental cultivation of important Unani Medicinal Plants
• Large scale cultivation of important medicinal plants
• Data base of 62,500 specimen of Unani Medicinal plants
• A database of 6500 tribal medicinal folk claims and published in 7 volumes
• Agro techniques developed for 25 Unani Medicinal plants some of the native of Egypt such as Atrilal (Ammi majusLinn ), Gulnar Farsi (Punica granatum Linn), Ustukhudoos
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Collection and dissemination of information
• Research and reference library
• 12,000 books
• International and National Seminars
• 40 National and 2 International
• 1650 research papers
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Publications
• Hippocratic journal of Unani medicine –half yearly
• Urdu journal Jahan-e-Tib- Quarterly
• Newsletter - quarterly
• Hand book of common remedies in Unani Medicine in 16 languages
• 195 publications including mongraphs, technical reports, booklets/leaflets.
• CDs/Video documentary/Audio films
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Areas of Collaboration
• Educational programmes
• Exchange of information on drug manufacturing technology of Unani medicine.
• Exchange of visitors.
• Setting up of an Institute of collaborative research programme
• Sharing of TKDL database
• Replication of Dr. RML Hospital module
• Unani medicine kitMutual collaboration for export and import of single drugs and compound formulations
• Exchange of manpower
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